SIMILAR PATTERNS OF AMINO ACIDS FOR 4PO0_A_NPSA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 VAL A 183
ASN A 186
LEU A  17
VAL A 147
LEU A  99
 None
 1.14A 4po0A-1b41A:
undetectable		 4po0A-1b41A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb) 		5 VAL A  61
CYH A  65
ARG A  18
VAL A  50
LEU A  25
 None
 1.44A 4po0A-1f0xA:
2.0		 4po0A-1f0xA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kij DNA GYRASE SUBUNIT B

(Thermus
thermophilus) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 VAL A 110
ASN A 271
PHE A 332
LEU A 340
SER A 324
 None
 1.26A 4po0A-1kijA:
undetectable		 4po0A-1kijA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE

(Xenopus laevis) 		no annotation 5 VAL A  90
CYH A 170
PHE A 166
VAL A 275
LEU A 270
 None
 1.37A 4po0A-1oe5A:
undetectable		 4po0A-1oe5A:
16.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 ASN A 391
PHE A 403
ARG A 410
LYS A 414
LEU A 453
SER A 489
 None
 0.85A 4po0A-1tf0A:
46.3		 4po0A-1tf0A:
74.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 ASN A 391
PHE A 403
LEU A 407
ARG A 410
LEU A 453
SER A 489
 None
 0.69A 4po0A-1tf0A:
46.3		 4po0A-1tf0A:
74.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 ASN A 391
PHE A 403
LEU A 407
TYR A 411
LEU A 453
ARG A 485
SER A 489
 None
 0.55A 4po0A-1tf0A:
46.3		 4po0A-1tf0A:
74.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 ASN A 391
PHE A 403
TYR A 411
LYS A 414
LEU A 453
ARG A 485
SER A 489
 None
 0.72A 4po0A-1tf0A:
46.3		 4po0A-1tf0A:
74.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttx ONCOMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 VAL A  44
PHE A  67
LEU A  68
VAL A 107
SER A   8
 None
 1.20A 4po0A-1ttxA:
undetectable		 4po0A-1ttxA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5f PYRUVATE OXIDASE

(Aerococcus
viridans) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ASN A 344
PHE A 577
LEU A 581
VAL A 211
SER A 338
 None
 1.38A 4po0A-1v5fA:
undetectable		 4po0A-1v5fA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysx SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 ASN A 391
CYH A 392
PHE A 403
LEU A 407
TYR A 411
 4EB  A1000 (-3.5A)
4EB  A1000 (-3.2A)
4EB  A1000 ( 4.1A)
4EB  A1000 (-4.5A)
4EB  A1000 (-3.3A)
 1.02A 4po0A-1ysxA:
5.8		 4po0A-1ysxA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2f EXOCYST COMPLEX
COMPONENT SEC15

(Drosophila
melanogaster) 		PF04091
(Sec15) 		5 CYH X 124
PHE X 121
LEU X 149
VAL X  27
SER X  74
 None
 1.31A 4po0A-2a2fX:
2.7		 4po0A-2a2fX:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0r POSSIBLE ADENYL
CYCLASE-ASSOCIATED
PROTEIN

(Cryptosporidium
parvum) 		PF08603
(CAP_C) 		5 VAL A  91
ASN A  73
LEU A  47
VAL A  87
LEU A  66
 None
 1.46A 4po0A-2b0rA:
undetectable		 4po0A-2b0rA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2edz PDZ
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00595
(PDZ) 		5 VAL A  70
TYR A  27
VAL A  62
LEU A  91
SER A  85
 None
 1.45A 4po0A-2edzA:
undetectable		 4po0A-2edzA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1) 		5 VAL A 123
ASN A 126
CYH A 127
LEU A  58
ARG A  50
 None
 1.28A 4po0A-2oewA:
2.2		 4po0A-2oewA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpm CYTOKININ
DEHYDROGENASE 1

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		5 VAL A 414
PHE A 459
LEU A 470
ARG A 469
ARG A 476
 None
 1.35A 4po0A-2qpmA:
2.3		 4po0A-2qpmA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		5 VAL A 159
CYH A 247
VAL A 171
LEU A 154
ARG A 157
 None
 1.26A 4po0A-2qvwA:
3.7		 4po0A-2qvwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5k MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
10) 		PF00500
(Late_protein_L1) 		5 VAL A 330
CYH A 154
LEU A 326
VAL A 104
LEU A 368
 None
 1.19A 4po0A-2r5kA:
undetectable		 4po0A-2r5kA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III

(Cinnamomum
camphora) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		5 VAL A 233
ARG A 224
VAL A 240
LEU A 548
SER A 196
 None
 1.31A 4po0A-2vlcA:
undetectable		 4po0A-2vlcA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vow SURFACE-ASSOCIATED
PROTEIN

(Methylococcus
capsulatus) 		no annotation 5 PHE A 280
LEU A 149
VAL A 329
ARG A  85
SER A 137
 None
 0.87A 4po0A-2vowA:
undetectable		 4po0A-2vowA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrk ALPHA-L-ARABINOFURAN
OSIDASE

(Thermobacillus
xylanilyticus) 		PF06964
(Alpha-L-AF_C) 		5 ASN A 175
ARG A  69
TYR A 125
VAL A 130
SER A 238
 None
 1.42A 4po0A-2vrkA:
undetectable		 4po0A-2vrkA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr7 MALONYLTRANSFERASE

(Nicotiana
tabacum) 		PF02458
(Transferase) 		5 VAL A 127
PHE A  42
LEU A 112
TYR A 111
VAL A 406
 None
 1.44A 4po0A-2xr7A:
undetectable		 4po0A-2xr7A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 VAL B 539
ASN B 605
LEU B 600
VAL B 544
LEU B 546
 None
 1.38A 4po0A-2z2mB:
undetectable		 4po0A-2z2mB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp. JT-ISH-224) 		PF11477
(PM0188) 		5 VAL A 381
PHE A 357
LEU A 394
VAL A 464
SER A 390
 None
 1.11A 4po0A-2z4tA:
undetectable		 4po0A-2z4tA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 VAL A 344
LEU A 243
TYR A 391
VAL A 338
ARG A 359
 None
 1.44A 4po0A-2zu6A:
undetectable		 4po0A-2zu6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 ASN A 599
PHE A 294
LEU A 319
LEU A 619
SER A 612
 None
 1.06A 4po0A-3cttA:
undetectable		 4po0A-3cttA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dan CYTOCHROME P450 74A2

(Parthenium
argentatum) 		PF00067
(p450) 		5 PHE A 439
LEU A 443
TYR A 447
VAL A 463
LEU A 465
 None
 1.47A 4po0A-3danA:
undetectable		 4po0A-3danA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egc PUTATIVE RIBOSE
OPERON REPRESSOR

(Burkholderia
thailandensis) 		PF00532
(Peripla_BP_1) 		5 ASN A 153
PHE A  81
ARG A 202
VAL A 164
ARG A 325
 None
 1.44A 4po0A-3egcA:
undetectable		 4po0A-3egcA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ers TRNA-BINDING PROTEIN
YGJH

(Escherichia
coli) 		PF01588
(tRNA_bind) 		5 VAL X  65
CYH X  81
LEU X  49
TYR X  53
VAL X  36
 None
 1.40A 4po0A-3ersX:
undetectable		 4po0A-3ersX:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opx PROTEIN SSM1

(Saccharomyces
cerevisiae) 		PF13419
(HAD_2) 		5 PHE A  35
LEU A 136
VAL A 251
LEU A 254
SER A 130
 None
 1.44A 4po0A-3opxA:
undetectable		 4po0A-3opxA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c ABL INTERACTOR 2
PROBABLE PROTEIN
BRICK1

(Homo sapiens) 		PF07815
(Abi_HHR)
no annotation 		5 CYH E  43
LEU E  36
VAL F  72
LEU F  68
ARG F  16
 None
 1.40A 4po0A-3p8cE:
undetectable		 4po0A-3p8cE:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		5 VAL A  64
LEU A  27
ARG A  58
VAL A  40
ARG A  56
 None
 1.33A 4po0A-3qbdA:
undetectable		 4po0A-3qbdA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		5 VAL B  45
LEU B 137
VAL B  90
LEU B  81
SER B  53
 None
 1.05A 4po0A-3s4wB:
2.6		 4po0A-3s4wB:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6k ACETYLGLUTAMATE
KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		5 VAL A  76
LEU A 281
VAL A  48
LEU A 213
SER A  63
 None
 1.38A 4po0A-3s6kA:
undetectable		 4po0A-3s6kA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8m ENOYL-ACP REDUCTASE

(Xanthomonas
oryzae) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		5 VAL A 268
ASN A 267
ARG A 220
TYR A 318
LEU A 312
 None
 1.29A 4po0A-3s8mA:
undetectable		 4po0A-3s8mA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhh NUCLEOPROTEIN

(California
encephalitis
orthobunyavirus) 		PF00952
(Bunya_nucleocap) 		5 PHE B  42
LEU B  99
VAL B  72
LEU B  90
ARG B  94
 None
None
None
None
U  R  16 ( 4.0A)
 1.33A 4po0A-4bhhB:
undetectable		 4po0A-4bhhB:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 VAL A 794
PHE A 771
LEU A 776
VAL A 809
LEU A 813
 None
 1.39A 4po0A-4c3hA:
3.5		 4po0A-4c3hA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 PHE B1397
LEU B1368
VAL B1452
LEU B1450
ARG B1486
 None
 1.23A 4po0A-4f92B:
3.1		 4po0A-4f92B:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 VAL A 176
LEU A  51
VAL A 132
LEU A 128
ARG A  67
 None
 1.47A 4po0A-4fp4A:
3.4		 4po0A-4fp4A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Escherichia
coli) 		PF02401
(LYTB) 		5 VAL A  40
ASN A  42
LEU A 274
VAL A  15
SER A 228
 10D  A 402 (-3.6A)
None
None
10D  A 402 (-4.7A)
10D  A 402 ( 4.8A)
 1.44A 4po0A-4h4cA:
undetectable		 4po0A-4h4cA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3o OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher)
PF13953
(PapC_C)
PF13954
(PapC_N) 		5 VAL D 733
PHE D 745
LEU D 715
VAL D 674
LEU D 702
 None
 1.10A 4po0A-4j3oD:
undetectable		 4po0A-4j3oD:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii) 		PF00398
(RrnaAD) 		5 VAL A 148
CYH A 152
LEU A 130
VAL A 195
LEU A 141
 None
IOD  A 307 ( 4.6A)
None
None
None
 1.06A 4po0A-4jxjA:
undetectable		 4po0A-4jxjA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		5 VAL A 122
PHE A  32
LEU A  65
TYR A  62
VAL A 333
 None
 1.27A 4po0A-4maaA:
undetectable		 4po0A-4maaA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		5 VAL A 207
ASN A 208
CYH A 231
TYR A 450
SER A 160
 None
None
None
PG0  A 900 (-3.7A)
None
 1.33A 4po0A-4madA:
undetectable		 4po0A-4madA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 VAL A 374
PHE A 341
LEU A 349
VAL A 395
LEU A 327
 None
 1.25A 4po0A-4qs9A:
undetectable		 4po0A-4qs9A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3

(Homo sapiens) 		PF10421
(OAS1_C) 		5 LEU A   3
TYR A   4
VAL A 255
LEU A 256
ARG A 253
 None
 1.41A 4po0A-4s3nA:
undetectable		 4po0A-4s3nA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d04 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Neisseria
meningitidis) 		PF00793
(DAHP_synth_1) 		5 LEU C 291
ARG C 346
VAL C  58
LEU C  89
ARG C  55
 None
None
None
None
EDO  C 408 (-3.5A)
 1.48A 4po0A-5d04C:
undetectable		 4po0A-5d04C:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d91 AF2299
PROTEIN,PHOSPHATIDYL
INOSITOL SYNTHASE

(Archaeoglobus
fulgidus;
Renibacterium
salmoninarum) 		PF01066
(CDP-OH_P_transf) 		5 VAL A 156
PHE A  99
TYR A  47
VAL A 176
LEU A 173
 None
 1.47A 4po0A-5d91A:
1.9		 4po0A-5d91A:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		8 VAL A 387
ASN A 390
PHE A 402
ARG A 409
LYS A 413
LEU A 452
ARG A 484
SER A 488
 None
 0.73A 4po0A-5dqfA:
50.0		 4po0A-5dqfA:
71.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		8 VAL A 387
ASN A 390
PHE A 402
ARG A 409
TYR A 410
LYS A 413
ARG A 484
SER A 488
 None
 0.64A 4po0A-5dqfA:
50.0		 4po0A-5dqfA:
71.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		8 VAL A 387
ASN A 390
PHE A 402
LEU A 406
ARG A 409
LEU A 452
ARG A 484
SER A 488
 None
 0.61A 4po0A-5dqfA:
50.0		 4po0A-5dqfA:
71.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		8 VAL A 387
ASN A 390
PHE A 402
LEU A 406
ARG A 409
TYR A 410
ARG A 484
SER A 488
 None
 0.48A 4po0A-5dqfA:
50.0		 4po0A-5dqfA:
71.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsz MACRODOMAIN

(Trypanosoma
cruzi) 		PF01661
(Macro) 		5 VAL A 137
PHE A  51
VAL A  38
LEU A  39
ARG A  35
 None
 1.02A 4po0A-5fszA:
undetectable		 4po0A-5fszA:
18.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		10 VAL A 388
ASN A 391
PHE A 403
LEU A 407
ARG A 410
TYR A 411
LYS A 414
LEU A 453
ARG A 485
SER A 489
 None
 0.54A 4po0A-5ghkA:
46.8		 4po0A-5ghkA:
74.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		5 VAL A 388
LEU A 430
LYS A 414
ARG A 485
SER A 489
 None
 1.21A 4po0A-5ghkA:
46.8		 4po0A-5ghkA:
74.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis) 		PF14592
(Chondroitinas_B) 		5 ASN A 229
PHE A 231
LEU A 238
ARG A 227
SER A 225
 None
 1.45A 4po0A-5gkqA:
undetectable		 4po0A-5gkqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL

(Aspergillus
nidulans) 		PF00579
(tRNA-synt_1b) 		5 VAL A 118
PHE A 337
LEU A  99
VAL A 124
LEU A 156
 None
 1.38A 4po0A-5ihxA:
undetectable		 4po0A-5ihxA:
20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 9 ASN A 390
PHE A 402
LEU A 406
ARG A 409
TYR A 410
LYS A 413
LEU A 452
ARG A 484
SER A 488
 None
 0.62A 4po0A-5oriA:
51.2		 4po0A-5oriA:
72.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ov3 RETINOBLASTOMA-BINDI
NG PROTEIN 5

(Mus musculus) 		no annotation 5 VAL A  41
CYH A  30
PHE A  32
VAL A 318
LEU A  21
 None
 1.40A 4po0A-5ov3A:
undetectable		 4po0A-5ov3A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgu RIBONUCLEASE R

(Escherichia
coli) 		no annotation 5 VAL B 575
LEU B 605
TYR B 596
VAL B 620
SER B 590
 None
 1.30A 4po0A-5xguB:
undetectable		 4po0A-5xguB:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgu RIBONUCLEASE R

(Escherichia
coli) 		no annotation 5 VAL B 575
TYR B 596
VAL B 620
LEU B 638
SER B 590
 None
 1.39A 4po0A-5xguB:
undetectable		 4po0A-5xguB:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 VAL A 388
ASN A 391
LEU A 430
TYR A 411
SER A 489
 None
 1.43A 4po0A-5yxeA:
45.4		 4po0A-5yxeA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 8 VAL A 388
ASN A 391
PHE A 403
LEU A 407
ARG A 410
TYR A 411
LYS A 414
LEU A 453
 None
 0.83A 4po0A-5yxeA:
45.4		 4po0A-5yxeA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 8 VAL A 388
ASN A 391
PHE A 403
LEU A 407
TYR A 411
LYS A 414
LEU A 453
ARG A 485
 None
 0.79A 4po0A-5yxeA:
45.4		 4po0A-5yxeA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 8 VAL A 388
ASN A 391
PHE A 403
LEU A 407
TYR A 411
LYS A 414
LEU A 453
SER A 489
 None
 0.65A 4po0A-5yxeA:
45.4		 4po0A-5yxeA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z95 -

(-) 		no annotation 5 VAL A 220
LEU A 198
VAL A 224
LEU A 228
SER A  98
 None
None
GOL  A 304 ( 4.3A)
None
None
 1.30A 4po0A-5z95A:
undetectable		 4po0A-5z95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6beg SCAFFOLD PROTEIN D13

(Vaccinia virus) 		no annotation 5 LEU A 255
VAL A 507
LEU A 443
ARG A 475
SER A 460
 None
 1.46A 4po0A-6begA:
undetectable		 4po0A-6begA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsp MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
9) 		no annotation 5 VAL C 333
CYH C 157
LEU C 329
VAL C 107
LEU C 372
 None
 1.12A 4po0A-6bspC:
undetectable		 4po0A-6bspC:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 5 VAL C1230
LEU C1148
VAL C1215
LEU C1177
ARG C1185
 None
 1.39A 4po0A-6en4C:
undetectable		 4po0A-6en4C:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71

(Danio rerio) 		no annotation 5 VAL A 496
PHE A 461
LEU A 518
VAL A 480
SER A 493
 None
 1.29A 4po0A-6fq3A:
undetectable		 4po0A-6fq3A:
9.07