SIMILAR PATTERNS OF AMINO ACIDS FOR 4PM7_A_CE3A301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1alq CP254 BETA-LACTAMASE

(Staphylococcus
aureus) 		PF13354
(Beta-lactamase2) 		7 LYS A  73
TYR A 105
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
 None
 0.79A 4pm7A-1alqA:
28.0		 4pm7A-1alqA:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bsg BETA LACTAMASE

(Streptomyces
albus) 		PF13354
(Beta-lactamase2) 		8 LYS A  73
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
ALA A 237
GLY A 238
 None
 0.40A 4pm7A-1bsgA:
42.6		 4pm7A-1bsgA:
46.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bsg BETA LACTAMASE

(Streptomyces
albus) 		PF13354
(Beta-lactamase2) 		8 LYS A  73
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
ALA A 237
GLY A 238
 None
 0.64A 4pm7A-1bsgA:
42.6		 4pm7A-1bsgA:
46.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bue PROTEIN
(IMIPENEM-HYDROLYSIN
G BETA-LACTAMASE)

(Enterobacter
cloacae) 		PF13354
(Beta-lactamase2) 		6 LYS A  73
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
 None
 0.72A 4pm7A-1bueA:
40.5		 4pm7A-1bueA:
48.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bue PROTEIN
(IMIPENEM-HYDROLYSIN
G BETA-LACTAMASE)

(Enterobacter
cloacae) 		PF13354
(Beta-lactamase2) 		6 LYS A  73
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
 None
 0.96A 4pm7A-1bueA:
40.5		 4pm7A-1bueA:
48.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dy6 CARBAPENEM-HYDROLYSI
NG BETA-LACTAMASE
SME-1

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		6 LYS A  73
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
 None
 0.67A 4pm7A-1dy6A:
41.1		 4pm7A-1dy6A:
47.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dy6 CARBAPENEM-HYDROLYSI
NG BETA-LACTAMASE
SME-1

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		6 LYS A  73
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
 None
 0.94A 4pm7A-1dy6A:
41.1		 4pm7A-1dy6A:
47.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e25 EXTENDED-SPECTRUM
BETA-LACTAMASE PER-1

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		6 LYS A  73
SER A 130
ASN A 132
THR A 216
LYS A 234
GLY A 236
 None
SO4  A 500 (-2.6A)
None
SO4  A 500 ( 4.0A)
SO4  A 500 (-3.2A)
SO4  A 500 (-3.5A)
 0.65A 4pm7A-1e25A:
32.5		 4pm7A-1e25A:
29.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g68 BETA-LACTAMASE PSE-4

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		8 LYS A  73
TYR A 105
SER A 130
ASN A 132
ASN A 170
GLY A 236
ALA A 237
GLY A 238
 SO4  A 400 ( 4.7A)
None
SO4  A 400 (-2.7A)
None
None
SO4  A 400 (-3.0A)
SO4  A 400 (-3.6A)
None
 0.48A 4pm7A-1g68A:
39.4		 4pm7A-1g68A:
39.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hzo BETA-LACTAMASE

(Proteus
vulgaris) 		PF13354
(Beta-lactamase2) 		8 LYS A  73
TYR A 105
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
GLY A 238
 None
MES  A1000 (-3.9A)
None
None
MES  A1000 (-3.7A)
MES  A1000 (-2.9A)
MES  A1000 (-3.1A)
None
 0.54A 4pm7A-1hzoA:
46.7		 4pm7A-1hzoA:
65.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hzo BETA-LACTAMASE

(Proteus
vulgaris) 		PF13354
(Beta-lactamase2) 		8 LYS A  73
TYR A 105
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
GLY A 238
 None
MES  A1000 (-3.9A)
MES  A1000 (-2.7A)
None
None
MES  A1000 (-2.9A)
MES  A1000 (-3.1A)
None
 0.73A 4pm7A-1hzoA:
46.7		 4pm7A-1hzoA:
65.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i2w BETA-LACTAMASE

(Bacillus
licheniformis) 		PF13354
(Beta-lactamase2) 		9 LYS A  73
ASN A 104
TYR A 105
ASN A 132
THR A 216
LYS A 234
GLY A 236
ALA A 237
GLY A 238
 CFX  A1300 (-2.6A)
CFX  A1300 (-3.9A)
CFX  A1300 ( 4.9A)
CFX  A1300 (-3.0A)
CFX  A1300 (-3.2A)
CFX  A1300 ( 3.9A)
CFX  A1300 (-3.3A)
CFX  A1300 (-3.4A)
CFX  A1300 ( 4.1A)
 0.44A 4pm7A-1i2wA:
41.2		 4pm7A-1i2wA:
43.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i2w BETA-LACTAMASE

(Bacillus
licheniformis) 		PF13354
(Beta-lactamase2) 		9 LYS A  73
ASN A 104
TYR A 105
SER A 130
ASN A 132
LYS A 234
GLY A 236
ALA A 237
GLY A 238
 CFX  A1300 (-2.6A)
CFX  A1300 (-3.9A)
CFX  A1300 ( 4.9A)
CFX  A1300 (-3.1A)
CFX  A1300 (-3.0A)
CFX  A1300 ( 3.9A)
CFX  A1300 (-3.3A)
CFX  A1300 (-3.4A)
CFX  A1300 ( 4.1A)
 0.63A 4pm7A-1i2wA:
41.2		 4pm7A-1i2wA:
43.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n4o L2 BETA-LACTAMASE

(Stenotrophomonas
maltophilia) 		PF13354
(Beta-lactamase2) 		7 LYS A  73
SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
 SO4  A1002 ( 4.9A)
SO4  A1002 (-3.1A)
None
None
SO4  A1002 ( 4.8A)
SO4  A1002 (-3.6A)
SO4  A1002 (-3.2A)
 0.67A 4pm7A-1n4oA:
40.4		 4pm7A-1n4oA:
46.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n9b BETA-LACTAMASE SHV-2

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		8 LYS A  73
TYR A 105
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
ALA A 237
 None
EPE  A 400 (-3.6A)
EPE  A 400 (-2.5A)
None
None
EPE  A 400 (-3.1A)
EPE  A 400 (-3.1A)
EPE  A 400 (-4.0A)
 0.43A 4pm7A-1n9bA:
35.6		 4pm7A-1n9bA:
40.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		5 LYS A  55
ASN A 301
THR A 394
LYS A 411
GLY A 413
 None
 0.48A 4pm7A-1w5dA:
21.1		 4pm7A-1w5dA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		5 LYS A  55
SER A 299
ASN A 301
LYS A 411
GLY A 413
 None
 0.73A 4pm7A-1w5dA:
21.1		 4pm7A-1w5dA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp4 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptococcus
pneumoniae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 LYS A  59
ASN A 121
THR A 221
LYS A 239
GLY A 241
 None
None
SO4  A 464 ( 4.0A)
SO4  A 464 (-3.5A)
SO4  A 464 ( 3.8A)
 0.47A 4pm7A-1xp4A:
20.6		 4pm7A-1xp4A:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		9 LYS A  73
TYR A 105
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
ALA A 237
GLY A 238
 None
 0.69A 4pm7A-1zg4A:
38.3		 4pm7A-1zg4A:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6w PENICILLIN-BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		6 LYS B 373
SER B 428
ASN B 430
THR B 543
LYS B 557
GLY B 559
 None
CL  B 704 (-3.4A)
None
CL  B 704 ( 4.8A)
None
CL  B 704 ( 4.0A)
 0.84A 4pm7A-2c6wB:
17.1		 4pm7A-2c6wB:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cc1 BETA-LACTAMASE

(Mycolicibacterium
fortuitum) 		PF13354
(Beta-lactamase2) 		8 LYS A  73
SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
GLY A 238
 None
 0.63A 4pm7A-2cc1A:
40.6		 4pm7A-2cc1A:
43.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		6 LYS B 463
TYR B 498
ASN B 518
THR B 629
LYS B 651
GLY B 653
 None
 0.69A 4pm7A-2fffB:
16.9		 4pm7A-2fffB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		6 LYS B 463
TYR B 498
SER B 516
ASN B 518
LYS B 651
GLY B 653
 None
 0.79A 4pm7A-2fffB:
16.9		 4pm7A-2fffB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwb METHICILLIN
RESISTANCE MECR1
PROTEIN

(Staphylococcus
aureus) 		PF00905
(Transpeptidase) 		6 LYS A 394
SER A 439
ASN A 441
LYS A 528
GLY A 530
GLY A 532
 GOL  A 605 ( 3.9A)
GOL  A 604 (-2.6A)
GOL  A 605 (-2.8A)
GOL  A 604 (-2.9A)
GOL  A 605 ( 3.2A)
None
 0.68A 4pm7A-2iwbA:
19.4		 4pm7A-2iwbA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jch PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		7 LYS A 463
TYR A 498
SER A 516
ASN A 518
THR A 629
LYS A 651
GLY A 653
 PL7  A1793 ( 4.0A)
PL7  A1793 (-4.3A)
PL7  A1793 (-3.0A)
PL7  A1793 (-3.2A)
PL7  A1793 ( 4.1A)
PL7  A1793 ( 4.1A)
PL7  A1793 (-3.3A)
 0.89A 4pm7A-2jchA:
15.8		 4pm7A-2jchA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2f PENICILLIN BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 LYS F 373
ASN F 430
THR F 543
LYS F 557
GLY F 559
 None
None
MES  F1653 (-3.7A)
MES  F1653 ( 4.0A)
MES  F1653 (-3.6A)
 0.68A 4pm7A-2v2fF:
17.9		 4pm7A-2v2fF:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2f PENICILLIN BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 SER F 428
ASN F 430
THR F 543
LYS F 557
GLY F 559
 MES  F1653 (-3.1A)
None
MES  F1653 (-3.7A)
MES  F1653 ( 4.0A)
MES  F1653 (-3.6A)
 0.68A 4pm7A-2v2fF:
17.9		 4pm7A-2v2fF:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wae PENICILLIN-BINDING
PROTEIN 2B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		6 LYS A 389
SER A 443
ASN A 445
THR A 600
LYS A 615
GLY A 617
 None
 0.70A 4pm7A-2waeA:
16.0		 4pm7A-2waeA:
17.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		7 GLY A 236
ASN A 104
TYR A 105
ASN A 170
THR A 216
LYS A 234
GLY A 238
 None
 1.43A 4pm7A-2wyxA:
46.0		 4pm7A-2wyxA:
83.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		9 LYS A  73
ASN A 104
TYR A 105
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
GLY A 238
 None
 0.48A 4pm7A-2wyxA:
46.0		 4pm7A-2wyxA:
83.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		8 LYS A  73
ASN A 104
TYR A 105
SER A 130
ASN A 132
LYS A 234
GLY A 236
GLY A 238
 None
 0.69A 4pm7A-2wyxA:
46.0		 4pm7A-2wyxA:
83.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		6 LYS B 340
SER B 395
ASN B 397
THR B 526
LYS B 547
GLY B 549
 CDS  B 901 ( 4.2A)
CDS  B 901 ( 3.2A)
CDS  B 901 ( 3.0A)
CDS  B 901 ( 4.1A)
CDS  B 901 ( 3.9A)
CDS  B 901 ( 3.4A)
 0.70A 4pm7A-2z2mB:
16.9		 4pm7A-2z2mB:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj9 AMPC

(Escherichia
coli) 		PF00144
(Beta-lactamase) 		5 LYS A  67
ASN A 152
LYS A 315
GLY A 317
ALA A 318
 None
 0.50A 4pm7A-2zj9A:
14.9		 4pm7A-2zj9A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3i PENICILLIN-BINDING
PROTEIN 4

(Haemophilus
influenzae) 		PF02113
(Peptidase_S13) 		5 LYS A  72
ASN A 312
THR A 401
LYS A 420
GLY A 422
 AIX  A 501 ( 4.0A)
AIX  A 501 (-3.3A)
AIX  A 501 ( 4.0A)
AIX  A 501 ( 3.8A)
AIX  A 501 (-3.4A)
 0.45A 4pm7A-3a3iA:
20.6		 4pm7A-3a3iA:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bfg CLASS A
BETA-LACTAMASE SED1

(Citrobacter
sedlakii) 		PF13354
(Beta-lactamase2) 		8 LYS A  73
ASN A 104
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
ALA A 237
 MER  A 301 ( 3.8A)
MER  A 301 ( 4.1A)
MER  A 301 (-3.2A)
MER  A 301 (-2.6A)
MER  A 301 (-3.6A)
MER  A 301 (-3.2A)
MER  A 301 (-3.0A)
MER  A 301 (-4.2A)
 0.51A 4pm7A-3bfgA:
46.8		 4pm7A-3bfgA:
75.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bfg CLASS A
BETA-LACTAMASE SED1

(Citrobacter
sedlakii) 		PF13354
(Beta-lactamase2) 		8 LYS A  73
ASN A 104
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
ALA A 237
 MER  A 301 ( 3.8A)
MER  A 301 ( 4.1A)
MER  A 301 (-2.6A)
MER  A 301 (-3.2A)
MER  A 301 (-2.6A)
MER  A 301 (-3.2A)
MER  A 301 (-3.0A)
MER  A 301 (-4.2A)
 0.68A 4pm7A-3bfgA:
46.8		 4pm7A-3bfgA:
75.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3byd BETA-LACTAMASE OXY-1

(Klebsiella
oxytoca) 		PF13354
(Beta-lactamase2) 		8 LYS A  76
ASN A 135
ASN A 173
THR A 219
LYS A 237
GLY A 239
ALA A 240
GLY A 241
 SO4  A 301 ( 4.9A)
None
None
SO4  A 301 ( 4.0A)
SO4  A 301 (-3.1A)
SO4  A 301 (-3.3A)
SO4  A 301 (-3.6A)
None
 0.31A 4pm7A-3bydA:
47.2		 4pm7A-3bydA:
74.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3byd BETA-LACTAMASE OXY-1

(Klebsiella
oxytoca) 		PF13354
(Beta-lactamase2) 		8 LYS A  76
SER A 133
ASN A 135
ASN A 173
LYS A 237
GLY A 239
ALA A 240
GLY A 241
 SO4  A 301 ( 4.9A)
SO4  A 301 (-2.8A)
None
None
SO4  A 301 (-3.1A)
SO4  A 301 (-3.3A)
SO4  A 301 (-3.6A)
None
 0.59A 4pm7A-3bydA:
47.2		 4pm7A-3bydA:
74.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwk PENICILLIN-BINDING
PROTEIN 2

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		6 LYS A 401
SER A 454
ASN A 456
LYS A 583
GLY A 585
GLY A 587
 SO4  A  26 ( 4.8A)
SO4  A  26 (-3.1A)
None
SO4  A  26 ( 4.2A)
SO4  A  26 (-3.3A)
None
 0.84A 4pm7A-3dwkA:
18.2		 4pm7A-3dwkA:
18.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dwz BETA-LACTAMASE

(Mycobacterium
tuberculosis) 		PF13354
(Beta-lactamase2) 		6 LYS A  87
ASN A 186
THR A 232
LYS A 250
GLY A 252
GLY A 254
 DWZ  A 400 (-2.6A)
DWZ  A 400 ( 4.0A)
DWZ  A 400 ( 4.5A)
DWZ  A 400 ( 3.8A)
DWZ  A 400 (-3.3A)
None
 0.51A 4pm7A-3dwzA:
41.0		 4pm7A-3dwzA:
45.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dwz BETA-LACTAMASE

(Mycobacterium
tuberculosis) 		PF13354
(Beta-lactamase2) 		6 LYS A  87
SER A 142
ASN A 186
LYS A 250
GLY A 252
GLY A 254
 DWZ  A 400 (-2.6A)
DWZ  A 400 (-2.7A)
DWZ  A 400 ( 4.0A)
DWZ  A 400 ( 3.8A)
DWZ  A 400 (-3.3A)
None
 0.78A 4pm7A-3dwzA:
41.0		 4pm7A-3dwzA:
45.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lez BETA-LACTAMASE

(Oceanobacillus
iheyensis) 		PF13354
(Beta-lactamase2) 		10 LYS A  88
TYR A 118
SER A 143
ASN A 145
ASN A 183
THR A 229
LYS A 247
GLY A 249
ALA A 250
GLY A 251
 None
EPE  A 305 (-3.3A)
EPE  A 305 (-2.5A)
None
None
EPE  A 305 ( 3.9A)
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
EPE  A 305 ( 4.1A)
None
 0.42A 4pm7A-3lezA:
41.4		 4pm7A-3lezA:
43.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfd D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACB

(Bacillus
subtilis) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 LYS A  63
SER A 115
ASN A 117
LYS A 220
GLY A 222
 CIT  A   1 ( 4.4A)
CIT  A   1 (-2.8A)
None
CIT  A   1 ( 3.7A)
CIT  A   1 (-3.3A)
 0.74A 4pm7A-3mfdA:
22.3		 4pm7A-3mfdA:
24.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p09 BETA-LACTAMASE

(Francisella
tularensis) 		PF13354
(Beta-lactamase2) 		7 LYS A  64
TYR A  98
SER A 122
ASN A 162
THR A 208
LYS A 226
GLY A 228
 None
None
SO4  A 288 (-2.7A)
None
SO4  A 288 ( 4.8A)
SO4  A 288 (-3.5A)
SO4  A 288 (-3.3A)
 0.98A 4pm7A-3p09A:
39.4		 4pm7A-3p09A:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q7z BETA-LACTAMASE
REGULATORY PROTEIN
BLAR1

(Staphylococcus
aureus) 		PF00905
(Transpeptidase) 		6 LYS A 392
SER A 437
ASN A 439
LYS A 526
GLY A 528
GLY A 530
 BOU  A 584 ( 3.9A)
BOU  A 584 (-2.8A)
BOU  A 584 (-3.5A)
BOU  A 584 (-3.3A)
BOU  A 584 (-3.7A)
BOU  A 584 ( 3.9A)
 0.72A 4pm7A-3q7zA:
18.1		 4pm7A-3q7zA:
20.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qhy BETA-LACTAMASE

(Bacillus
anthracis) 		PF13354
(Beta-lactamase2) 		8 LYS A  73
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
ALA A 237
GLY A 238
 None
 0.51A 4pm7A-3qhyA:
41.8		 4pm7A-3qhyA:
43.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qhy BETA-LACTAMASE

(Bacillus
anthracis) 		PF13354
(Beta-lactamase2) 		8 LYS A  73
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
ALA A 237
GLY A 238
 None
 0.66A 4pm7A-3qhyA:
41.8		 4pm7A-3qhyA:
43.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rju BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE

(Yersinia pestis) 		PF00144
(Beta-lactamase) 		5 LYS A  62
ASN A 158
LYS A 299
GLY A 301
GLY A 303
 CIT  A 391 ( 4.4A)
CIT  A 391 ( 4.7A)
CIT  A 391 ( 4.4A)
CIT  A 391 (-3.3A)
None
 0.50A 4pm7A-3rjuA:
14.8		 4pm7A-3rjuA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		6 LYS A 339
SER A 390
ASN A 392
THR A 511
LYS A 525
GLY A 527
 None
 0.88A 4pm7A-3ue3A:
17.0		 4pm7A-3ue3A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v39 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		5 LYS A  73
ASN A 253
THR A 342
LYS A 357
GLY A 359
 TAU  A 501 ( 3.7A)
TAU  A 501 (-3.1A)
None
TAU  A 501 ( 4.3A)
TAU  A 501 (-3.5A)
 0.42A 4pm7A-3v39A:
17.8		 4pm7A-3v39A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v39 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		5 LYS A  73
SER A 251
ASN A 253
LYS A 357
GLY A 359
 TAU  A 501 ( 3.7A)
TAU  A 501 (-2.6A)
TAU  A 501 (-3.1A)
TAU  A 501 ( 4.3A)
TAU  A 501 (-3.5A)
 0.72A 4pm7A-3v39A:
17.8		 4pm7A-3v39A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsk PENICILLIN-BINDING
PROTEIN 3

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		6 LYS A 395
SER A 448
ASN A 450
THR A 603
LYS A 618
GLY A 620
 None
 0.81A 4pm7A-3vskA:
16.7		 4pm7A-3vskA:
18.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w4q BETA-LACTAMASE

(Burkholderia
multivorans) 		PF13354
(Beta-lactamase2) 		8 LYS A  73
TYR A 105
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
GLY A 238
 None
 0.70A 4pm7A-3w4qA:
43.9		 4pm7A-3w4qA:
57.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zdj ENCA BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		9 LYS A  73
TYR A 105
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
ALA A 237
GLY A 238
 None
None
SO4  A1291 (-3.1A)
None
None
SO4  A1291 (-3.3A)
SO4  A1291 (-3.3A)
SO4  A1291 (-3.9A)
None
 0.69A 4pm7A-3zdjA:
38.6		 4pm7A-3zdjA:
44.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg8 PENICILLIN-BINDING
PROTEIN 4

(Listeria
monocytogenes) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		6 LYS B 397
SER B 449
ASN B 451
THR B 561
LYS B 575
GLY B 577
 AIX  B 800 ( 3.1A)
AIX  B 800 (-2.4A)
AIX  B 800 (-2.7A)
AIX  B 800 ( 3.8A)
AIX  B 800 ( 4.0A)
AIX  B 800 ( 3.7A)
 0.79A 4pm7A-3zg8B:
17.6		 4pm7A-3zg8B:
19.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zny CTX-M-12A ENZYME

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		8 LYS A  73
TYR A 105
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
GLY A 238
 None
 0.42A 4pm7A-3znyA:
47.3		 4pm7A-3znyA:
81.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zny CTX-M-12A ENZYME

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		8 LYS A  73
TYR A 105
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
GLY A 238
 None
 0.63A 4pm7A-3znyA:
47.3		 4pm7A-3znyA:
81.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Actinomadura
sp. R39) 		PF02113
(Peptidase_S13) 		5 LYS A  52
ASN A 300
THR A 393
LYS A 410
GLY A 412
 B07  A 500 (-3.4A)
B07  A 500 ( 4.2A)
B07  A 500 ( 4.8A)
B07  A 500 (-1.6A)
B07  A 500 (-3.2A)
 0.39A 4pm7A-3zvtA:
21.0		 4pm7A-3zvtA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Actinomadura
sp. R39) 		PF02113
(Peptidase_S13) 		5 LYS A  52
SER A 298
ASN A 300
LYS A 410
GLY A 412
 B07  A 500 (-3.4A)
B07  A 500 (-1.4A)
B07  A 500 ( 4.2A)
B07  A 500 (-1.6A)
B07  A 500 (-3.2A)
 0.73A 4pm7A-3zvtA:
21.0		 4pm7A-3zvtA:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c6y BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		8 LYS A  73
SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
GLY A 238
 PEG  A 307 ( 3.6A)
PEG  A 307 (-2.4A)
PEG  A 307 (-3.1A)
PEG  A 307 ( 4.3A)
PEG  A 307 ( 4.3A)
PEG  A 307 ( 3.4A)
PEG  A 307 (-2.7A)
None
 0.63A 4pm7A-4c6yA:
43.3		 4pm7A-4c6yA:
58.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c6y BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		8 LYS A  73
TYR A 105
SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 238
 PEG  A 307 ( 3.6A)
PEG  A 307 ( 3.2A)
PEG  A 307 (-2.4A)
PEG  A 307 (-3.1A)
PEG  A 307 ( 4.3A)
PEG  A 307 ( 4.3A)
PEG  A 307 ( 3.4A)
None
 0.86A 4pm7A-4c6yA:
43.3		 4pm7A-4c6yA:
58.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c75 BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		9 LYS A  73
TYR A 105
SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
GLY A 238
 SO4  A 291 ( 4.6A)
None
SO4  A 291 (-2.8A)
None
None
SO4  A 291 ( 4.1A)
SO4  A 291 (-3.4A)
NA  A 294 ( 3.2A)
None
 0.68A 4pm7A-4c75A:
42.7		 4pm7A-4c75A:
57.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d2o PER-2 BETA-LACTAMASE

(Citrobacter
freundii) 		PF13354
(Beta-lactamase2) 		6 LYS A  73
SER A 130
ASN A 132
THR A 216
LYS A 234
GLY A 236
 None
 0.57A 4pm7A-4d2oA:
32.3		 4pm7A-4d2oA:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola) 		PF13354
(Beta-lactamase2) 		6 LYS A  73
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
 MER  A 401 ( 4.4A)
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.6A)
 0.58A 4pm7A-4ev4A:
42.0		 4pm7A-4ev4A:
48.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Eggerthella
lenta) 		PF00905
(Transpeptidase) 		6 LYS A 185
SER A 237
ASN A 239
THR A 383
LYS A 397
GLY A 399
 None
 0.71A 4pm7A-4mnrA:
17.7		 4pm7A-4mnrA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovd PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		6 LYS A 308
ASN A 363
THR A 486
LYS A 500
GLY A 502
GLY A 504
 None
None
CA  A 601 ( 4.7A)
CA  A 601 ( 4.1A)
CA  A 601 ( 4.2A)
None
 0.88A 4pm7A-4ovdA:
17.7		 4pm7A-4ovdA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		6 LYS A 685
SER A 737
ASN A 739
THR A 876
LYS A 890
GLY A 892
 NXU  A1001 ( 4.2A)
NXU  A1001 (-3.2A)
NXU  A1001 (-3.5A)
NXU  A1001 (-4.0A)
NXU  A1001 (-3.5A)
NXU  A1001 (-3.4A)
 0.70A 4pm7A-4ra7A:
17.0		 4pm7A-4ra7A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rye D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		5 LYS A  72
SER A 124
ASN A 126
LYS A 230
GLY A 232
 None
 0.70A 4pm7A-4ryeA:
21.9		 4pm7A-4ryeA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LYS A 324
SER A 376
ASN A 378
LYS A 520
GLY A 522
 None
 0.56A 4pm7A-4ye5A:
16.6		 4pm7A-4ye5A:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yfm BETA-LACTAMASE

(Mycobacteroides
abscessus) 		PF13354
(Beta-lactamase2) 		8 LYS A  74
SER A 131
ASN A 133
ASN A 171
THR A 215
LYS A 233
GLY A 235
GLY A 237
 ACT  A 301 ( 4.8A)
ACT  A 301 (-2.9A)
None
None
ACT  A 301 (-3.7A)
ACT  A 301 (-3.4A)
ACT  A 301 (-3.3A)
None
 0.65A 4pm7A-4yfmA:
41.7		 4pm7A-4yfmA:
44.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztk CELL DIVISION
PROTEIN
FTSI/PENICILLIN
BINDING PROTEIN 2

(Legionella
pneumophila) 		PF00905
(Transpeptidase) 		6 LYS A 403
SER A 454
ASN A 456
THR A 554
LYS A 568
GLY A 570
 None
NHE  A 901 (-2.9A)
None
NHE  A 901 ( 4.2A)
NHE  A 901 (-3.0A)
NHE  A 901 (-3.6A)
 0.78A 4pm7A-4ztkA:
16.8		 4pm7A-4ztkA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		8 LYS A 203
SER A 260
ASN A 262
ASN A 300
LYS A 364
GLY A 366
ALA A 367
GLY A 368
 None
 0.68A 4pm7A-5aqaA:
37.5		 4pm7A-5aqaA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		6 LYS A 203
TYR A 235
SER A 260
ASN A 262
LYS A 364
GLY A 366
 None
 1.42A 4pm7A-5aqaA:
37.5		 4pm7A-5aqaA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		5 LYS A  61
ASN A 241
THR A 330
LYS A 345
GLY A 347
 None
 0.35A 4pm7A-5cerA:
18.4		 4pm7A-5cerA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		5 LYS A  61
SER A 239
ASN A 241
LYS A 345
GLY A 347
 None
 0.71A 4pm7A-5cerA:
18.4		 4pm7A-5cerA:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e2e BETA-LACTAMASE

(Yersinia
enterocolitica) 		PF13354
(Beta-lactamase2) 		8 LYS A  50
TYR A  82
ASN A 109
ASN A 147
THR A 193
LYS A 211
GLY A 213
GLY A 215
 None
 0.63A 4pm7A-5e2eA:
44.3		 4pm7A-5e2eA:
58.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e2e BETA-LACTAMASE

(Yersinia
enterocolitica) 		PF13354
(Beta-lactamase2) 		8 LYS A  50
TYR A  82
SER A 107
ASN A 109
ASN A 147
LYS A 211
GLY A 213
GLY A 215
 None
 0.80A 4pm7A-5e2eA:
44.3		 4pm7A-5e2eA:
58.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e31 PENICILLIN BINDING
PROTEIN 2 PRIME

(Enterococcus
faecium) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		5 SER A 480
ASN A 482
THR A 603
LYS A 617
GLY A 619
 None
 0.74A 4pm7A-5e31A:
16.9		 4pm7A-5e31A:
19.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e43 BETA-LACTAMASE

(Streptosporangium
roseum) 		PF13354
(Beta-lactamase2) 		7 LYS A  73
SER A 131
ASN A 133
ASN A 171
THR A 217
LYS A 235
GLY A 237
 None
ACT  A 311 (-3.0A)
None
None
ACT  A 311 ( 3.9A)
ACT  A 311 (-3.3A)
ACT  A 311 (-3.2A)
 0.64A 4pm7A-5e43A:
42.7		 4pm7A-5e43A:
41.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eoe BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		7 LYS A  65
TYR A  97
ASN A 125
ASN A 163
THR A 209
LYS A 227
GLY A 229
 CIT  A 303 (-3.6A)
CIT  A 303 (-4.1A)
CIT  A 303 (-3.2A)
None
CIT  A 303 (-3.2A)
CIT  A 303 (-3.5A)
CIT  A 303 (-3.5A)
 0.54A 4pm7A-5eoeA:
40.7		 4pm7A-5eoeA:
41.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eoe BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		7 LYS A  65
TYR A  97
SER A 123
ASN A 125
ASN A 163
LYS A 227
GLY A 229
 CIT  A 303 (-3.6A)
CIT  A 303 (-4.1A)
CIT  A 303 (-2.5A)
CIT  A 303 (-3.2A)
None
CIT  A 303 (-3.5A)
CIT  A 303 (-3.5A)
 0.75A 4pm7A-5eoeA:
40.7		 4pm7A-5eoeA:
41.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f83 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		5 LYS A  67
ASN A 127
THR A 211
LYS A 229
GLY A 231
 IM2  A 301 ( 3.9A)
IM2  A 301 (-3.2A)
IM2  A 301 (-4.1A)
IM2  A 301 (-3.3A)
IM2  A 301 (-3.3A)
 0.30A 4pm7A-5f83A:
39.4		 4pm7A-5f83A:
37.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f83 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		5 LYS A  67
SER A 125
ASN A 127
LYS A 229
GLY A 231
 IM2  A 301 ( 3.9A)
IM2  A 301 (-2.7A)
IM2  A 301 (-3.2A)
IM2  A 301 (-3.3A)
IM2  A 301 (-3.3A)
 0.74A 4pm7A-5f83A:
39.4		 4pm7A-5f83A:
37.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gl9 BETA-LACTAMASE

(Burkholderia
thailandensis) 		PF13354
(Beta-lactamase2) 		8 LYS A  73
SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
GLY A 238
 None
 0.60A 4pm7A-5gl9A:
45.0		 4pm7A-5gl9A:
57.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gl9 BETA-LACTAMASE

(Burkholderia
thailandensis) 		PF13354
(Beta-lactamase2) 		7 LYS A  73
TYR A 105
SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
 None
 0.88A 4pm7A-5gl9A:
45.0		 4pm7A-5gl9A:
57.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlb PENICILLIN-BINDING
PROTEIN 1B

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF14814
(UB2H) 		6 LYS A 513
SER A 572
ASN A 574
THR A 682
LYS A 698
GLY A 700
 AZR  A 902 ( 4.0A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.3A)
 0.81A 4pm7A-5hlbA:
18.5		 4pm7A-5hlbA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hql RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		6 GLY A 188
TYR A 182
THR A 223
GLY A 187
ALA A 405
GLY A 404
 None
 1.30A 4pm7A-5hqlA:
undetectable		 4pm7A-5hqlA:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hw3 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		5 LYS A  73
SER A 131
ASN A 133
ASN A 171
GLY A 235
 None
SO4  A 301 (-2.6A)
None
ACT  A 310 (-4.0A)
SO4  A 301 (-3.4A)
 0.71A 4pm7A-5hw3A:
39.8		 4pm7A-5hw3A:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hx9 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		5 GLY A  70
ASN A 170
LYS A 234
GLY A 236
GLY A 238
 EDO  A 303 (-3.6A)
None
EDO  A 303 (-2.6A)
None
None
 0.23A 4pm7A-5hx9A:
41.3		 4pm7A-5hx9A:
46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ihv BETA-LACTAMASE

(Burkholderia
ambifaria) 		PF13354
(Beta-lactamase2) 		5 GLY A  47
ASN A 147
LYS A 211
GLY A 213
GLY A 215
 EDO  A 302 (-3.6A)
None
EDO  A 302 (-2.8A)
None
None
 0.23A 4pm7A-5ihvA:
41.8		 4pm7A-5ihvA:
49.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ll7 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 7 LYS A  73
SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
 6YV  A 301 ( 3.8A)
6YV  A 301 (-2.6A)
6YV  A 301 (-3.7A)
6YV  A 301 (-2.9A)
6YV  A 301 ( 4.2A)
6YV  A 301 (-3.6A)
6YV  A 301 ( 4.0A)
 0.71A 4pm7A-5ll7A:
43.0		 4pm7A-5ll7A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tfq BETA-LACTAMASE

(Bacteroides
cellulosilyticus) 		PF13354
(Beta-lactamase2) 		7 LYS A  51
TYR A  85
SER A 112
ASN A 114
THR A 197
LYS A 215
GLY A 217
 None
None
PO4  A 301 (-2.6A)
None
PO4  A 301 ( 3.8A)
PO4  A 301 (-3.2A)
PO4  A 301 (-3.3A)
 0.62A 4pm7A-5tfqA:
33.0		 4pm7A-5tfqA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2g PENICILLIN-BINDING
PROTEIN 1A

(Haemophilus
influenzae) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		6 LYS A 455
SER A 510
ASN A 512
THR A 712
LYS A 728
GLY A 730
 None
 0.81A 4pm7A-5u2gA:
17.8		 4pm7A-5u2gA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		6 LYS A 346
SER A 402
ASN A 404
THR A 532
LYS A 553
GLY A 555
 None
 0.66A 4pm7A-5u47A:
17.2		 4pm7A-5u47A:
17.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vpq BETA-LACTAMASE

(Paraburkholderia
phymatum) 		PF13354
(Beta-lactamase2) 		5 ASN A 121
ASN A 159
THR A 206
GLY A 227
GLY A 229
 None
None
None
None
EDO  A 304 (-3.4A)
 0.68A 4pm7A-5vpqA:
41.3		 4pm7A-5vpqA:
48.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x49 PROBABLE XAA-PRO
AMINOPEPTIDASE 3

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		6 GLY A 307
TYR A 455
ASN A 311
THR A 346
GLY A 306
ALA A 305
 None
 1.22A 4pm7A-5x49A:
undetectable		 4pm7A-5x49A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5g BETA-LACTAMASE

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		6 LYS A  59
SER A 120
ASN A 122
THR A 206
LYS A 224
GLY A 226
 OP0  A 305 (-3.6A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.6A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
 0.63A 4pm7A-5x5gA:
34.5		 4pm7A-5x5gA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqe -

(-) 		no annotation 5 LYS A  61
ASN A 120
THR A 208
LYS A 222
GLY A 224
 CES  A 301 ( 4.1A)
CES  A 301 (-3.3A)
CES  A 301 (-4.3A)
None
CES  A 301 (-3.2A)
 0.38A 4pm7A-5zqeA:
22.0		 4pm7A-5zqeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azi D-ALANYL-D-ALANINE
ENDOPEPTIDASE

(Enterobacter
cloacae) 		PF00768
(Peptidase_S11) 		5 LYS A  71
ASN A 127
THR A 217
LYS A 232
GLY A 234
 SEE  A  68 ( 2.8A)
SEE  A  68 ( 3.6A)
None
SEE  A  68 ( 3.5A)
SEE  A  68 ( 3.9A)
 0.47A 4pm7A-6aziA:
21.4		 4pm7A-6aziA:
27.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6bu3 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 10 LYS A  73
ASN A 104
TYR A 105
SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
GLY A 238
 3GK  A 301 ( 4.0A)
3GK  A 301 ( 3.2A)
3GK  A 302 ( 3.5A)
3GK  A 301 (-2.7A)
3GK  A 301 (-3.5A)
3GK  A 301 (-3.9A)
3GK  A 302 ( 4.3A)
3GK  A 301 ( 4.1A)
3GK  A 301 (-3.4A)
3GK  A 301 (-3.6A)
 0.46A 4pm7A-6bu3A:
48.6		 4pm7A-6bu3A:
97.50