SIMILAR PATTERNS OF AMINO ACIDS FOR 4PL1_B_SAMB401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 6 CYH B 132
GLU B 180
PRO B 181
SER B 211
HIS B 235
TRP B 311
 SF4  B 401 (-2.1A)
SF4  B 401 ( 4.8A)
None
None
None
None
 0.59A 4pl1B-4pl2B:
52.7		 4pl1B-4pl2B:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 6 CYH B 132
GLU B 180
PRO B 181
SER B 211
SER B 233
HIS B 235
 SF4  B 401 (-2.1A)
SF4  B 401 ( 4.8A)
None
None
SF4  B 401 ( 4.8A)
None
 0.52A 4pl1B-4pl2B:
52.7		 4pl1B-4pl2B:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 6 CYH B 132
MET B 176
GLU B 180
PRO B 181
SER B 211
SER B 233
 SF4  B 401 (-2.1A)
None
SF4  B 401 ( 4.8A)
None
None
SF4  B 401 ( 4.8A)
 0.70A 4pl1B-4pl2B:
52.7		 4pl1B-4pl2B:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hr6 RLMN METHYLASE

(Escherichia
coli) 		PF04055
(Radical_SAM) 		9 CYH A 132
MET A 176
GLU A 180
PRO A 181
SER A 211
SER A 233
HIS A 235
TRP A 311
ASN A 312
 SF4  A 502 ( 2.2A)
A  C  37 ( 3.7A)
MET  A 501 (-4.0A)
MET  A 501 ( 4.9A)
MET  A 501 (-2.5A)
MET  A 501 ( 2.6A)
5AD  A 503 (-3.7A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.41A 4pl1B-5hr6A:
51.9		 4pl1B-5hr6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hr6 RLMN METHYLASE

(Escherichia
coli) 		PF04055
(Radical_SAM) 		7 CYH A 132
MET A 176
SER A 233
HIS A 235
GLU A 278
TRP A 311
ASN A 312
 SF4  A 502 ( 2.2A)
A  C  37 ( 3.7A)
MET  A 501 ( 2.6A)
5AD  A 503 (-3.7A)
5AD  A 503 (-3.1A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.85A 4pl1B-5hr6A:
51.9		 4pl1B-5hr6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF04055
(Radical_SAM)
PF13353
(Fer4_12) 		5 CYH A  88
GLU A 127
PRO A 128
HIS A 201
ASN A 226
 SF4  A 401 (-2.4A)
SAH  A 402 (-4.3A)
None
None
None
 1.38A 4pl1B-5vslA:
16.3		 4pl1B-5vslA:
20.51