SIMILAR PATTERNS OF AMINO ACIDS FOR 4PL1_A_SAMA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 PHE A 187
PRO A  46
SER A 173
ILE A 155
ASN A 159
 None
None
GLU  A 701 (-4.5A)
None
None
 1.39A 4pl1A-2e4uA:
1.4		 4pl1A-2e4uA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwe PHOSPHOINOSITIDE-3-K
INASE, CLASS 2,
GAMMA POLYPEPTIDE

(Homo sapiens) 		PF00787
(PX) 		5 GLU A1306
SER A1232
HIS A1226
ILE A1204
ASN A1295
 None
 1.49A 4pl1A-2wweA:
0.0		 4pl1A-2wweA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 PHE A 195
PRO A  56
SER A 181
ILE A 163
ASN A 167
 None
None
Z99  A 514 (-4.6A)
None
None
 1.32A 4pl1A-3mq4A:
2.0		 4pl1A-3mq4A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 PHE A 162
PRO A  21
SER A 148
ILE A 130
ASN A 134
 None
CL  A 486 ( 3.9A)
Z99  A 485 (-4.6A)
None
SO4  A 480 (-3.4A)
 1.36A 4pl1A-3sm9A:
1.9		 4pl1A-3sm9A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nji 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE

(Burkholderia
multivorans) 		PF13394
(Fer4_14) 		5 PHE A  48
GLU A 116
SER A 133
ILE A 152
ASN A 183
 SAM  A 302 (-4.8A)
2K8  A 303 ( 3.9A)
SAM  A 302 (-2.8A)
None
None
 1.36A 4pl1A-4njiA:
7.5		 4pl1A-4njiA:
22.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 7 PHE B 131
GLU B 180
PRO B 181
SER B 211
HIS B 235
ILE B 309
TRP B 311
 SF4  B 401 ( 4.6A)
SF4  B 401 ( 4.8A)
None
None
None
None
None
 0.64A 4pl1A-4pl2B:
50.8		 4pl1A-4pl2B:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 7 PHE B 131
GLU B 180
PRO B 181
SER B 211
SER B 233
HIS B 235
ILE B 309
 SF4  B 401 ( 4.6A)
SF4  B 401 ( 4.8A)
None
None
SF4  B 401 ( 4.8A)
None
None
 0.48A 4pl1A-4pl2B:
50.8		 4pl1A-4pl2B:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 5 PHE B 131
HIS B 235
GLU B 278
ILE B 309
TRP B 311
 SF4  B 401 ( 4.6A)
None
None
None
None
 0.99A 4pl1A-4pl2B:
50.8		 4pl1A-4pl2B:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 7 PHE B 131
MET B 176
GLU B 180
PRO B 181
SER B 211
SER B 233
ILE B 309
 SF4  B 401 ( 4.6A)
None
SF4  B 401 ( 4.8A)
None
None
SF4  B 401 ( 4.8A)
None
 0.72A 4pl1A-4pl2B:
50.8		 4pl1A-4pl2B:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 5 PHE B 131
MET B 176
SER B 233
GLU B 278
ILE B 309
 SF4  B 401 ( 4.6A)
None
SF4  B 401 ( 4.8A)
None
None
 1.16A 4pl1A-4pl2B:
50.8		 4pl1A-4pl2B:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 5 PHE B 131
SER B 233
HIS B 235
GLU B 278
ILE B 309
 SF4  B 401 ( 4.6A)
SF4  B 401 ( 4.8A)
None
None
None
 0.91A 4pl1A-4pl2B:
50.8		 4pl1A-4pl2B:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 PHE A 181
PRO A  39
SER A 167
ILE A 149
ASN A 153
 None
CL  A 602 ( 4.0A)
GGL  A 601 (-4.5A)
None
None
 1.37A 4pl1A-5cniA:
1.6		 4pl1A-5cniA:
20.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hr6 RLMN METHYLASE

(Escherichia
coli) 		PF04055
(Radical_SAM) 		10 PHE A 131
MET A 176
GLU A 180
PRO A 181
SER A 211
SER A 233
HIS A 235
ILE A 309
TRP A 311
ASN A 312
 5AD  A 503 (-4.6A)
A  C  37 ( 3.7A)
MET  A 501 (-4.0A)
MET  A 501 ( 4.9A)
MET  A 501 (-2.5A)
MET  A 501 ( 2.6A)
5AD  A 503 (-3.7A)
5AD  A 503 (-4.1A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.46A 4pl1A-5hr6A:
49.5		 4pl1A-5hr6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hr6 RLMN METHYLASE

(Escherichia
coli) 		PF04055
(Radical_SAM) 		7 PHE A 131
MET A 176
HIS A 235
GLU A 278
ILE A 309
TRP A 311
ASN A 312
 5AD  A 503 (-4.6A)
A  C  37 ( 3.7A)
5AD  A 503 (-3.7A)
5AD  A 503 (-3.1A)
5AD  A 503 (-4.1A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.88A 4pl1A-5hr6A:
49.5		 4pl1A-5hr6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 PHE A 181
PRO A  39
SER A 167
ILE A 149
ASN A 153
 None
 1.31A 4pl1A-5kznA:
1.8		 4pl1A-5kznA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubp LEUCINE PERMEASE
TRANSCRIPTIONAL
REGULATOR

(Saccharomyces
cerevisiae) 		PF03399
(SAC3_GANP) 		5 PHE A 282
GLU A 208
PRO A 205
ILE A 268
ASN A 271
 None
 1.38A 4pl1A-5ubpA:
undetectable		 4pl1A-5ubpA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsz METABOTROPIC
GLUTAMATE RECEPTOR 8

(Homo sapiens) 		no annotation 5 PHE A 192
PRO A  53
SER A 178
ILE A 160
ASN A 164
 None
None
GGL  A 601 (-4.6A)
None
None
 1.34A 4pl1A-6bszA:
1.0		 4pl1A-6bszA:
undetectable