SIMILAR PATTERNS OF AMINO ACIDS FOR 4PH9_A_IBPA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1au8 CATHEPSIN G

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A  52
LEU A  68
ALA A  85
SER A 109
LEU A 108
 None
 0.81A 4ph9A-1au8A:
0.0		 4ph9A-1au8A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh6 SUBTILISIN DY

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 VAL A 148
LEU A 250
GLY A  23
ALA A 232
SER A 236
 None
 1.11A 4ph9A-1bh6A:
0.5		 4ph9A-1bh6A:
18.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		9 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.39A 4ph9A-1ebvA:
58.8		 4ph9A-1ebvA:
64.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecx AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00266
(Aminotran_5) 		5 VAL A 152
VAL A 340
GLY A 347
ALA A 348
SER A 298
 None
 1.11A 4ph9A-1ecxA:
0.0		 4ph9A-1ecxA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ept PORCINE E-TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 VAL A  52
LEU B  67
ALA B  85
SER B 109
LEU B 108
 None
 0.97A 4ph9A-1eptA:
undetectable		 4ph9A-1eptA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gns SUBTILISIN BPN'

(Bacillus
amyloliquefaciens) 		PF00082
(Peptidase_S8) 		5 VAL A 148
LEU A 250
GLY A  23
ALA A 232
SER A 236
 None
 1.10A 4ph9A-1gnsA:
0.0		 4ph9A-1gnsA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtk PORPHOBILINOGEN
DEAMINASE

(Escherichia
coli) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		5 VAL A 152
ARG A 155
VAL A 109
LEU A 174
GLY A 126
 None
DPM  A 315 (-2.7A)
None
None
None
 1.07A 4ph9A-1gtkA:
0.0		 4ph9A-1gtkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4w TRYPSIN IVA

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A  52
LEU A  67
ALA A  85
SER A 109
LEU A 108
 None
 0.99A 4ph9A-1h4wA:
undetectable		 4ph9A-1h4wA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 VAL E  52
LEU E  67
ALA E  85
SER E 109
LEU E 108
 None
 0.95A 4ph9A-1h9hE:
0.0		 4ph9A-1h9hE:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpg GLUTAMIC ACID
SPECIFIC PROTEASE

(Streptomyces
griseus) 		no annotation 5 VAL A  48
VAL A 231
LEU A 235
GLY A 197
ALA A  45
 None
 1.03A 4ph9A-1hpgA:
undetectable		 4ph9A-1hpgA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8d RIBOFLAVIN SYNTHASE

(Escherichia
coli) 		PF00677
(Lum_binding) 		5 VAL A  59
LEU A  28
GLY A  39
ALA A  40
LEU A  36
 None
 1.02A 4ph9A-1i8dA:
undetectable		 4ph9A-1i8dA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imj CCG1-INTERACTING
FACTOR B

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		5 VAL A  96
VAL A  65
LEU A  36
GLY A  10
LEU A 100
 None
 1.06A 4ph9A-1imjA:
undetectable		 4ph9A-1imjA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		5 VAL T  52
LEU T  68
ALA T  85
SER T 109
LEU T 108
 None
 1.00A 4ph9A-1j17T:
undetectable		 4ph9A-1j17T:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 VAL A2814
VAL A2795
LEU A2852
GLY A2798
ALA A2797
 None
 1.03A 4ph9A-1js8A:
undetectable		 4ph9A-1js8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		5 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.88A 4ph9A-1jy1A:
undetectable		 4ph9A-1jy1A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		5 VAL A 332
LEU A  81
GLY A 179
ALA A 178
LEU A 125
 None
 0.94A 4ph9A-1l8wA:
undetectable		 4ph9A-1l8wA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odi PURINE NUCLEOSIDE
PHOSPHORYLASE

(Thermus
thermophilus) 		PF01048
(PNP_UDP_1) 		5 VAL A  17
VAL A  73
LEU A  77
GLY A  21
LEU A  19
 None
None
None
SO4  A1236 (-3.1A)
None
 1.11A 4ph9A-1odiA:
0.8		 4ph9A-1odiA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p33 PTERIDINE REDUCTASE
1

(Leishmania
tarentolae) 		PF13561
(adh_short_C2) 		5 VAL A  33
LEU A  51
GLY A  13
ALA A  14
LEU A  35
 None
None
NDP  A 300 (-3.6A)
None
None
 1.14A 4ph9A-1p33A:
undetectable		 4ph9A-1p33A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 VAL A 558
VAL A 606
LEU A 615
GLY A 593
LEU A 560
 None
 0.79A 4ph9A-1ps9A:
undetectable		 4ph9A-1ps9A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhb TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 VAL A  52
LEU A  67
ALA A  85
SER A 109
LEU A 108
 None
 0.97A 4ph9A-1uhbA:
undetectable		 4ph9A-1uhbA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 VAL A 291
VAL A 160
GLY A 264
ALA A 262
LEU A 270
 None
 0.96A 4ph9A-1vc2A:
undetectable		 4ph9A-1vc2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w52 PANCREATIC LIPASE
RELATED PROTEIN 2

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 VAL X 223
VAL X 174
GLY X 156
ALA X 157
LEU X 193
 None
 1.13A 4ph9A-1w52X:
undetectable		 4ph9A-1w52X:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aiz OUTER MEMBRANE
PROTEIN P6

(Haemophilus
influenzae) 		PF00691
(OmpA) 		5 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 0.99A 4ph9A-2aizP:
undetectable		 4ph9A-2aizP:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awf UBIQUITIN-CONJUGATIN
G ENZYME E2 G1

(Homo sapiens) 		PF00179
(UQ_con) 		5 VAL A  22
VAL A 117
GLY A  28
ALA A  27
LEU A  17
 None
 1.10A 4ph9A-2awfA:
undetectable		 4ph9A-2awfA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayz SENSOR KINASE
PROTEIN RCSC

(Escherichia
coli) 		PF00072
(Response_reg) 		5 VAL A 899
LEU A 897
GLY A 857
ALA A 860
SER A 874
 None
 1.11A 4ph9A-2ayzA:
undetectable		 4ph9A-2ayzA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 VAL A1143
GLY A1182
ALA A1183
SER A1186
LEU A1187
 None
 1.13A 4ph9A-2bruA:
undetectable		 4ph9A-2bruA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		5 VAL A 437
VAL A 419
LEU A 413
GLY A 456
LEU A 463
 None
 1.08A 4ph9A-2csdA:
undetectable		 4ph9A-2csdA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 VAL A  42
LEU A  34
GLY A  87
ALA A  88
LEU A  92
 None
 0.94A 4ph9A-2dieA:
undetectable		 4ph9A-2dieA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		5 VAL A 282
TYR A 265
LEU A 274
SER A 252
LEU A 251
 None
 1.11A 4ph9A-2i9kA:
undetectable		 4ph9A-2i9kA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsv UNCHARACTERIZED
PROTEIN

(Porphyromonas
gingivalis) 		PF07610
(DUF1573) 		5 VAL A  27
ARG A  61
VAL A  39
LEU A  84
LEU A  63
 None
 1.08A 4ph9A-2qsvA:
undetectable		 4ph9A-2qsvA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgy CYTOCHROME P450 130

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 VAL A  90
VAL A 290
LEU A 293
GLY A 244
ALA A 243
 HEM  A 450 (-3.2A)
HEM  A 450 (-4.6A)
HEM  A 450 (-4.4A)
HEM  A 450 (-3.4A)
HEM  A 450 (-3.5A)
 1.02A 4ph9A-2wgyA:
0.2		 4ph9A-2wgyA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis) 		PF00995
(Sec1) 		5 VAL A  83
LEU A 113
GLY A  69
ALA A  97
LEU A  99
 None
 1.05A 4ph9A-2xheA:
undetectable		 4ph9A-2xheA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xj9 MIPZ

(Caulobacter
vibrioides) 		PF09140
(MipZ) 		5 VAL A 183
TYR A 159
LEU A 143
GLY A  15
ALA A  16
 None
None
None
AGS  A1272 (-3.3A)
AGS  A1272 (-4.2A)
 1.09A 4ph9A-2xj9A:
undetectable		 4ph9A-2xj9A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5l TYLACTONE SYNTHASE
STARTER MODULE AND
MODULES 1 & 2

(Streptomyces
fradiae) 		PF08659
(KR) 		5 VAL A 456
ARG A   7
GLY A 231
ALA A 230
SER A   1
 None
 1.01A 4ph9A-2z5lA:
undetectable		 4ph9A-2z5lA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adr PUTATIVE
UNCHARACTERIZED
PROTEIN ST1585

(Sulfurisphaera
tokodaii) 		PF00753
(Lactamase_B) 		5 VAL A  78
LEU A  88
GLY A  37
ALA A  36
LEU A  56
 None
 1.03A 4ph9A-3adrA:
undetectable		 4ph9A-3adrA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brk GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE

(Agrobacterium
tumefaciens) 		PF00483
(NTP_transferase) 		5 VAL X 376
VAL X  38
LEU X  29
GLY X  41
LEU X 361
 None
 1.09A 4ph9A-3brkX:
undetectable		 4ph9A-3brkX:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emk GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		5 VAL A  33
LEU A  50
GLY A  13
ALA A  14
LEU A  35
 None
 1.03A 4ph9A-3emkA:
undetectable		 4ph9A-3emkA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esm UNCHARACTERIZED
PROTEIN

(Nocardia
farcinica) 		PF07987
(DUF1775) 		5 VAL A 126
VAL A  45
GLY A  36
ALA A  37
LEU A 120
 None
 1.10A 4ph9A-3esmA:
undetectable		 4ph9A-3esmA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grp 3-OXOACYL-(ACYL
CARRIERPROTEIN)
REDUCTASE

(Bartonella
henselae) 		PF13561
(adh_short_C2) 		5 VAL A  33
LEU A  50
GLY A  13
ALA A  14
LEU A  35
 None
 1.04A 4ph9A-3grpA:
undetectable		 4ph9A-3grpA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae) 		PF00891
(Methyltransf_2) 		5 VAL A 200
VAL A 251
LEU A 253
GLY A 182
LEU A 207
 None
 1.01A 4ph9A-3gxoA:
undetectable		 4ph9A-3gxoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		PF00271
(Helicase_C) 		5 VAL A 339
VAL A 228
LEU A 232
GLY A 343
LEU A 341
 None
 0.95A 4ph9A-3i32A:
undetectable		 4ph9A-3i32A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE

(Shewanella
amazonensis) 		PF08668
(HDOD) 		5 VAL A 113
LEU A 180
GLY A 159
ALA A 160
LEU A 164
 None
 1.11A 4ph9A-3i7aA:
undetectable		 4ph9A-3i7aA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khn MOTB PROTEIN,
PUTATIVE

(Desulfovibrio
vulgaris) 		PF00691
(OmpA) 		5 VAL A 116
VAL A  49
GLY A  65
ALA A  66
LEU A  70
 None
 0.94A 4ph9A-3khnA:
undetectable		 4ph9A-3khnA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la2 GLOBAL NITROGEN
REGULATOR

(Nostoc sp. PCC
7120) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 VAL A 108
LEU A 112
GLY A  76
SER A  79
LEU A  80
 None
None
AKG  A 224 (-3.1A)
None
None
 0.92A 4ph9A-3la2A:
undetectable		 4ph9A-3la2A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moi PROBABLE
DEHYDROGENASE

(Bordetella
bronchiseptica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 TYR A 278
LEU A 273
GLY A 258
ALA A 259
LEU A 263
 None
 1.12A 4ph9A-3moiA:
undetectable		 4ph9A-3moiA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpl VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		5 VAL A 313
GLY A 331
ALA A 334
SER A 333
LEU A 337
 None
 1.13A 4ph9A-3mplA:
undetectable		 4ph9A-3mplA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq2 16S RRNA
METHYLTRANSFERASE

(Streptoalloteichus
tenebrarius) 		PF02390
(Methyltransf_4) 		5 VAL A  31
VAL A 126
LEU A  90
GLY A  97
LEU A  29
 None
 1.11A 4ph9A-3mq2A:
undetectable		 4ph9A-3mq2A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		5 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 1.00A 4ph9A-3nixA:
undetectable		 4ph9A-3nixA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohe HISTIDINE TRIAD
(HIT) PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF01230
(HIT) 		5 VAL A 124
VAL A  34
LEU A  25
GLY A  67
LEU A 128
 None
 1.08A 4ph9A-3oheA:
undetectable		 4ph9A-3oheA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re1 UROPORPHYRINOGEN-III
SYNTHETASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02602
(HEM4) 		5 LEU A   7
GLY A 202
ALA A 201
SER A 204
LEU A 208
 None
 1.12A 4ph9A-3re1A:
undetectable		 4ph9A-3re1A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 VAL A 485
VAL A 272
LEU A 267
GLY A 479
LEU A 483
 None
 1.00A 4ph9A-3redA:
undetectable		 4ph9A-3redA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whi SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 VAL A 238
LEU A 340
GLY A 113
ALA A 322
SER A 326
 None
 1.11A 4ph9A-3whiA:
undetectable		 4ph9A-3whiA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE

(Methanosarcina
mazei) 		PF01208
(URO-D) 		5 VAL A 262
LEU A 249
GLY A 310
ALA A 269
LEU A 282
 None
 1.07A 4ph9A-4ay7A:
undetectable		 4ph9A-4ay7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 VAL A1568
VAL A1549
LEU A1611
GLY A1552
ALA A1551
 None
 1.12A 4ph9A-4bedA:
1.0		 4ph9A-4bedA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccs CBIX

(Paracoccus
pantotrophus) 		PF01903
(CbiX) 		5 VAL A   8
LEU A  74
GLY A  48
ALA A  49
LEU A  44
 None
None
None
None
EDO  A1229 (-3.9A)
 1.09A 4ph9A-4ccsA:
undetectable		 4ph9A-4ccsA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		5 VAL A  64
LEU A  50
GLY A 340
ALA A 341
LEU A 344
 None
None
LLP  A  77 ( 4.7A)
None
None
 1.02A 4ph9A-4d9iA:
0.4		 4ph9A-4d9iA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomyces
pombe) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		5 VAL A1155
LEU A1062
ALA A1080
SER A1083
LEU A1084
 None
 1.13A 4ph9A-4fbqA:
undetectable		 4ph9A-4fbqA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomyces
pombe) 		no annotation 5 VAL B 155
LEU B  62
ALA B  80
SER B  83
LEU B  84
 None
 1.06A 4ph9A-4fcxB:
undetectable		 4ph9A-4fcxB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU

(Yersinia pestis) 		PF01032
(FecCD) 		5 VAL A  65
VAL A 309
LEU A 186
GLY A 258
LEU A 291
 None
 1.11A 4ph9A-4g1uA:
undetectable		 4ph9A-4g1uA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huj UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored) 		5 VAL A  63
VAL A  79
LEU A  58
GLY A 119
ALA A 120
 None
 1.00A 4ph9A-4hujA:
undetectable		 4ph9A-4hujA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ina SACCHAROPINE
DEHYDROGENASE

(Wolinella
succinogenes) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 VAL A   4
VAL A  16
GLY A 354
ALA A 355
LEU A  81
 None
 0.94A 4ph9A-4inaA:
undetectable		 4ph9A-4inaA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw1 EFFECTOR PROTEIN B

(Legionella
pneumophila) 		no annotation 5 VAL A 153
LEU A 214
ALA A 141
SER A 145
LEU A 142
 None
 1.12A 4ph9A-4jw1A:
undetectable		 4ph9A-4jw1A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Sanguibacter
keddieii) 		PF13377
(Peripla_BP_3) 		5 VAL A 278
GLY A 262
ALA A 263
SER A 266
LEU A 267
 None
 0.93A 4ph9A-4kmrA:
undetectable		 4ph9A-4kmrA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbv 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE PUTATIVE
SHORT-CHAIN
DEHYDROGENASES/REDUC
TASES (SDR) FAMILY
PROTEIN

(Cupriavidus
taiwanensis) 		PF13561
(adh_short_C2) 		5 VAL A  32
LEU A  49
GLY A  12
ALA A  13
LEU A  34
 None
 1.07A 4ph9A-4nbvA:
undetectable		 4ph9A-4nbvA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pn3 3-HYDROXYACYL-COA
DEHYDROGENASE

(Brucella
melitensis) 		PF00106
(adh_short) 		5 VAL A  32
LEU A  49
GLY A  12
ALA A  13
LEU A  34
 None
 1.03A 4ph9A-4pn3A:
undetectable		 4ph9A-4pn3A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 VAL B 442
VAL B 577
LEU B 348
GLY B 464
LEU B 483
 None
 0.95A 4ph9A-4qiwB:
undetectable		 4ph9A-4qiwB:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE SMALL
SUBUNIT

(Aquincola
tertiaricarbonis) 		PF02310
(B12-binding) 		5 VAL C  59
VAL C  25
LEU C  29
GLY C  93
SER C  63
 None
B12  C 800 (-4.9A)
None
B12  C 800 (-3.4A)
B12  C 800 (-2.9A)
 1.14A 4ph9A-4r3uC:
undetectable		 4ph9A-4r3uC:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A  81
LEU A  96
GLY A 111
ALA A 110
SER A 170
 None
 1.05A 4ph9A-4rjkA:
undetectable		 4ph9A-4rjkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rti OXYGEN-EVOLVING
ENHANCER PROTEIN 2,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF01789
(PsbP) 		5 VAL A  30
VAL A  61
LEU A  59
GLY A  23
LEU A  28
 None
 1.08A 4ph9A-4rtiA:
undetectable		 4ph9A-4rtiA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u28 PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
sviceus) 		PF00977
(His_biosynth) 		5 VAL A 189
VAL A 135
LEU A 152
GLY A 201
LEU A 185
 None
None
None
PO4  A 301 (-3.6A)
None
 1.00A 4ph9A-4u28A:
undetectable		 4ph9A-4u28A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u GLOBIN C CHAIN

(Glossoscolex
paulistus) 		PF00042
(Globin) 		5 VAL C 106
GLY C 143
ALA C 146
SER C 147
LEU C 149
 HEM  C 201 (-4.2A)
None
None
None
None
 1.08A 4ph9A-4u8uC:
undetectable		 4ph9A-4u8uC:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwy TRYPSIN-1

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A  52
LEU A  67
ALA A  85
SER A 109
LEU A 108
 None
 0.99A 4ph9A-4wwyA:
undetectable		 4ph9A-4wwyA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcm CELL WALL-BINDING
ENDOPEPTIDASE-RELATE
D PROTEIN

(Thermus
thermophilus) 		PF00877
(NLPC_P60)
PF01476
(LysM) 		5 VAL A 159
VAL A 244
LEU A 192
GLY A 167
LEU A 170
 None
 1.12A 4ph9A-4xcmA:
undetectable		 4ph9A-4xcmA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zck GTP-BINDING PROTEIN
TYPA/BIPA

(Escherichia
coli) 		PF00679
(EFG_C) 		5 VAL A 403
VAL A 415
LEU A 419
GLY A 463
LEU A 405
 None
 1.02A 4ph9A-4zckA:
undetectable		 4ph9A-4zckA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6a PYRIDOXAL KINASE
PDXY

(Pseudomonas
aeruginosa) 		PF08543
(Phos_pyr_kin) 		6 VAL A  98
ARG A 101
LEU A   8
GLY A  71
ALA A  70
LEU A  75
 None
 1.43A 4ph9A-5b6aA:
1.5		 4ph9A-5b6aA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpt MGC81278 PROTEIN

(Xenopus laevis) 		PF12894
(ANAPC4_WD40)
PF12896
(ANAPC4) 		5 VAL A 241
LEU A 207
GLY A 184
ALA A 182
LEU A 166
 None
 0.97A 4ph9A-5bptA:
undetectable		 4ph9A-5bptA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0u ALKYLMERCURY LYASE

(Escherichia
coli) 		PF03243
(MerB)
PF12324
(HTH_15) 		5 VAL A 189
VAL A 113
LEU A 126
ALA A  97
LEU A 101
 None
 0.89A 4ph9A-5c0uA:
undetectable		 4ph9A-5c0uA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dus ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01661
(Macro) 		5 VAL A 158
LEU A 162
GLY A 128
ALA A 127
LEU A 124
 None
None
APR  A 201 (-3.3A)
APR  A 201 (-3.9A)
None
 0.88A 4ph9A-5dusA:
undetectable		 4ph9A-5dusA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egn ESTERASE

(uncultured
bacterium) 		PF12697
(Abhydrolase_6) 		5 VAL A  75
LEU A  79
GLY A  96
ALA A  99
LEU A 102
 None
 1.09A 4ph9A-5egnA:
undetectable		 4ph9A-5egnA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4z EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		5 LEU A 328
GLY A 177
ALA A 178
SER A 181
LEU A 182
 None
 0.85A 4ph9A-5f4zA:
undetectable		 4ph9A-5f4zA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq8 BT_2262
(UNCHARACTERISED
LIPOPROTEIN)

(Bacteroides
thetaiotaomicron) 		PF16403
(DUF5011)
PF16404
(DUF5012) 		5 VAL G 172
TYR G 141
LEU G 137
GLY G 202
ALA G 201
 None
 1.05A 4ph9A-5fq8G:
undetectable		 4ph9A-5fq8G:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		5 VAL A 437
VAL A 419
LEU A 413
GLY A 456
LEU A 463
 None
 1.10A 4ph9A-5hm5A:
undetectable		 4ph9A-5hm5A:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		9 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TRP A 387
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.62A 4ph9A-5ikrA:
63.0		 4ph9A-5ikrA:
88.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		9 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.32A 4ph9A-5ikrA:
63.0		 4ph9A-5ikrA:
88.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk7 URACIL-DNA
GLYCOSYLASE

(Homo sapiens) 		PF03167
(UDG) 		5 VAL D 229
VAL D 137
LEU D 201
SER D 237
LEU D 233
 None
 1.01A 4ph9A-5jk7D:
undetectable		 4ph9A-5jk7D:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9z PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		5 VAL A  42
LEU A  59
GLY A  22
ALA A  23
LEU A  44
 None
 1.08A 4ph9A-5k9zA:
undetectable		 4ph9A-5k9zA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 VAL A 162
LEU A 247
GLY A 198
ALA A 197
LEU A 194
 None
 1.06A 4ph9A-5kdxA:
0.6		 4ph9A-5kdxA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxf FLOWERING TIME
CONTROL PROTEIN FPA

(Arabidopsis
thaliana) 		PF07744
(SPOC) 		5 VAL A 557
LEU A 546
GLY A 523
ALA A 522
LEU A 483
 None
 1.11A 4ph9A-5kxfA:
undetectable		 4ph9A-5kxfA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF00483
(NTP_transferase) 		5 VAL A 383
VAL A  45
LEU A  36
GLY A  48
LEU A 368
 None
 1.12A 4ph9A-5l6sA:
undetectable		 4ph9A-5l6sA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb8 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		5 LEU A  93
GLY A  55
ALA A  56
SER A  59
LEU A  60
 None
 0.88A 4ph9A-5lb8A:
undetectable		 4ph9A-5lb8A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		5 VAL A 735
LEU A 745
ALA A 700
SER A 741
LEU A 737
 None
 1.06A 4ph9A-5m60A:
undetectable		 4ph9A-5m60A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		5 VAL A  73
VAL A 199
LEU A 214
GLY A 202
LEU A 178
 None
 1.12A 4ph9A-5mq6A:
undetectable		 4ph9A-5mq6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT

(Homo sapiens) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		5 ARG B 196
VAL B 205
TYR B 211
ALA B 195
SER B 198
 None
 1.08A 4ph9A-5of4B:
undetectable		 4ph9A-5of4B:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5syn ACYL-PROTEIN
THIOESTERASE 2

(Homo sapiens) 		PF02230
(Abhydrolase_2) 		5 VAL A 220
VAL A  27
LEU A  44
GLY A 141
LEU A 224
 None
 0.96A 4ph9A-5synA:
undetectable		 4ph9A-5synA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpb HISTONE DEACETYLASE
6

(Homo sapiens) 		PF02148
(zf-UBP) 		5 VAL A1190
VAL A1119
LEU A1172
ALA A1194
LEU A1195
 None
 1.00A 4ph9A-5wpbA:
undetectable		 4ph9A-5wpbA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Trypanosoma
brucei) 		no annotation 5 VAL A  50
VAL A 255
GLY A 307
SER A  40
LEU A  39
 None
 1.03A 4ph9A-5x8oA:
undetectable		 4ph9A-5x8oA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF04212
(MIT) 		5 VAL A 186
LEU A 273
GLY A 140
ALA A 141
LEU A 145
 None
 1.10A 4ph9A-5xmiA:
undetectable		 4ph9A-5xmiA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ya1 AUTOINDUCER-2 KINASE

(Escherichia
coli) 		no annotation 5 VAL A  87
LEU A 179
GLY A  39
ALA A  26
LEU A  17
 None
 1.09A 4ph9A-5ya1A:
undetectable		 4ph9A-5ya1A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 5 VAL A  80
LEU A  90
GLY A  35
SER A  33
LEU A  38
 None
 1.12A 4ph9A-6en4A:
undetectable		 4ph9A-6en4A:
9.68