SIMILAR PATTERNS OF AMINO ACIDS FOR 4PGF_B_ADNB502_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dgs | DNA LIGASE (Thermusfiliformis) |
PF01653(DNA_ligase_aden)PF03120(DNA_ligase_OB)PF12826(HHH_2)PF14520(HHH_5) | 4 | THR A 149THR A 211THR A 72ASN A 21 | None | 1.38A | 4pgfB-1dgsA:undetectable | 4pgfB-1dgsA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dxy | D-2-HYDROXYISOCAPROATE DEHYDROGENASE (Lactobacilluscasei) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 4 | THR A 264THR A 212HIS A 213ASN A 231 | None | 1.40A | 4pgfB-1dxyA:4.5 | 4pgfB-1dxyA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e8c | UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATELIGASE (Escherichiacoli) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 4 | THR A 122THR A 123HIS A 359ASN A 205 | NoneNoneAPI A1499 (-3.7A)None | 1.28A | 4pgfB-1e8cA:2.6 | 4pgfB-1e8cA:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eq2 | ADP-L-GLYCERO-D-MANNOHEPTOSE 6-EPIMERASE (Escherichiacoli) |
PF01370(Epimerase) | 4 | THR A 81THR A 82HIS A 187ASN A 169 | ADQ A2500 (-4.0A)NoneADQ A2500 (-3.8A)ADQ A2500 (-3.7A) | 1.16A | 4pgfB-1eq2A:6.3 | 4pgfB-1eq2A:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ffv | CUTL, MOLYBDOPROTEINOF CARBON MONOXIDEDEHYDROGENASE (Hydrogenophagapseudoflava) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 4 | THR B 519THR B 561THR B 650HIS B 748 | NonePCD B1920 ( 4.3A)NoneNone | 1.33A | 4pgfB-1ffvB:undetectable | 4pgfB-1ffvB:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hxj | BETA-GLUCOSIDASE (Zea mays) |
PF00232(Glyco_hydro_1) | 4 | THR A 400THR A 183HIS A 233ASN A 321 | None | 1.43A | 4pgfB-1hxjA:undetectable | 4pgfB-1hxjA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n60 | CARBON MONOXIDEDEHYDROGENASE LARGECHAIN (Oligotrophacarboxidovorans) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 4 | THR B 525THR B 567THR B 656HIS B 754 | NoneMCN B4920 (-3.8A)NoneNone | 1.19A | 4pgfB-1n60B:undetectable | 4pgfB-1n60B:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1odt | CEPHALOSPORIN CDEACETYLASE (Bacillussubtilis) |
PF05448(AXE1) | 4 | THR C 178THR C 187THR C 272HIS C 298 | NoneNoneNoneACT C1318 (-4.0A) | 1.35A | 4pgfB-1odtC:4.4 | 4pgfB-1odtC:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tuu | ACETATE KINASE (Methanosarcinathermophila) |
PF00871(Acetate_kinase) | 4 | THR A 382THR A 329THR A 226HIS A 152 | None | 1.28A | 4pgfB-1tuuA:undetectable | 4pgfB-1tuuA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wqa | PHOSPHO-SUGAR MUTASE (Pyrococcushorikoshii) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 4 | THR A 284THR A 305THR A 7ASN A 328 | THR A 284 ( 0.8A)THR A 305 ( 0.8A)THR A 7 ( 0.8A)ASN A 328 ( 0.6A) | 1.35A | 4pgfB-1wqaA:2.4 | 4pgfB-1wqaA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y4j | SULFATASE MODIFYINGFACTOR 2 (Homo sapiens) |
PF03781(FGE-sulfatase) | 4 | THR A 238THR A 273HIS A 267ASN A 285 | None | 1.42A | 4pgfB-1y4jA:undetectable | 4pgfB-1y4jA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zef | ALKALINE PHOSPHATASE (Homo sapiens) |
PF00245(Alk_phosphatase) | 4 | THR A 149THR A 147THR A 95HIS A 358 | MG A 903 ( 4.6A)NoneSEP A 92 ( 4.1A) ZN A 902 (-3.2A) | 1.31A | 4pgfB-1zefA:undetectable | 4pgfB-1zefA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iir | ACETATE KINASE (Thermotogamaritima) |
PF00871(Acetate_kinase) | 4 | THR A 384THR A 329THR A 225HIS A 151 | None | 1.18A | 4pgfB-2iirA:undetectable | 4pgfB-2iirA:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ilx | 2',3'-CYCLIC-NUCLEOTIDE3'-PHOSPHODIESTERASE (Rattusnorvegicus) |
PF05881(CNPase) | 4 | THR A 115THR A 164THR A 73HIS A 71 | None | 1.21A | 4pgfB-2ilxA:undetectable | 4pgfB-2ilxA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jmr | FIMF (Escherichiacoli) |
PF00419(Fimbrial) | 4 | THR A 140THR A 135HIS A 75ASN A 84 | None | 1.40A | 4pgfB-2jmrA:undetectable | 4pgfB-2jmrA:16.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q27 | OXALYL-COADECARBOXYLASE (Escherichiacoli) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 4 | THR A 340THR A 339HIS A 256ASN A 349 | None | 1.34A | 4pgfB-2q27A:4.5 | 4pgfB-2q27A:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qa2 | POLYKETIDE OXYGENASECABE (Streptomyces) |
PF01494(FAD_binding_3) | 4 | THR A 47THR A 50HIS A 278ASN A 332 | None | 1.27A | 4pgfB-2qa2A:undetectable | 4pgfB-2qa2A:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r5v | PCZA361.1 (Amycolatopsisorientalis) |
PF00903(Glyoxalase)PF14696(Glyoxalase_5) | 4 | THR A 113THR A 125THR A 55HIS A 40 | None | 1.30A | 4pgfB-2r5vA:undetectable | 4pgfB-2r5vA:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rdy | BH0842 PROTEIN (Bacillushalodurans) |
PF14498(Glyco_hyd_65N_2) | 4 | THR A 272THR A 269THR A 44ASN A 22 | None | 1.19A | 4pgfB-2rdyA:undetectable | 4pgfB-2rdyA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vr5 | GLYCOGEN OPERONPROTEIN GLGX (Sulfolobussolfataricus) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C)PF02922(CBM_48) | 4 | THR A 329THR A 327HIS A 470ASN A 240 | A16 A1722 ( 4.4A)NoneA16 A1722 (-4.0A)None | 1.34A | 4pgfB-2vr5A:undetectable | 4pgfB-2vr5A:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x86 | ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE (Escherichiacoli) |
PF01370(Epimerase) | 4 | THR A 81THR A 82HIS A 187ASN A 169 | ADP A 401 ( 3.7A)NoneADP A 401 (-4.1A)ADP A 401 (-3.9A) | 1.22A | 4pgfB-2x86A:5.7 | 4pgfB-2x86A:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xf2 | CATALASE (Penicilliumjanthinellum) |
PF00199(Catalase)PF06628(Catalase-rel) | 4 | THR A 100THR A 123THR A 75ASN A 312 | None | 1.25A | 4pgfB-2xf2A:4.8 | 4pgfB-2xf2A:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b4w | ALDEHYDEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF00171(Aldedh) | 4 | THR A 438THR A 252HIS A 471ASN A 464 | NoneNoneGOL A 603 (-3.7A)None | 1.22A | 4pgfB-3b4wA:3.3 | 4pgfB-3b4wA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bfg | CLASS ABETA-LACTAMASE SED1 (Citrobactersedlakii) |
PF13354(Beta-lactamase2) | 4 | THR A 103THR A 133THR A 76ASN A 170 | NoneNoneNoneMER A 301 (-2.6A) | 1.36A | 4pgfB-3bfgA:undetectable | 4pgfB-3bfgA:20.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 71THR A 74THR A 219HIS A 363ASN A 409 | ADN A 500 (-2.8A)ADN A 500 (-4.5A)NAD A 550 ( 2.8A)ADN A 500 ( 3.7A)NAD A 550 (-3.0A) | 0.32A | 4pgfB-3ce6A:55.4 | 4pgfB-3ce6A:54.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 219THR A 220THR A 336ASN A 409 | NAD A 550 ( 2.8A)NAD A 550 (-3.1A)NoneNAD A 550 (-3.0A) | 1.36A | 4pgfB-3ce6A:55.4 | 4pgfB-3ce6A:54.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 221THR A 219THR A 257ASN A 360 | NAD A 550 (-3.7A)NAD A 550 ( 2.8A)NoneNone | 1.31A | 4pgfB-3ce6A:55.4 | 4pgfB-3ce6A:54.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 257THR A 221HIS A 363ASN A 360 | NoneNAD A 550 (-3.7A)ADN A 500 ( 3.7A)None | 1.06A | 4pgfB-3ce6A:55.4 | 4pgfB-3ce6A:54.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e5z | PUTATIVEGLUCONOLACTONASE (Deinococcusradiodurans) |
PF08450(SGL) | 4 | THR A 274THR A 258THR A 190ASN A 72 | NoneNoneNone MG A 297 ( 4.4A) | 1.24A | 4pgfB-3e5zA:undetectable | 4pgfB-3e5zA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ew2 | RHIZAVIDIN (Rhizobium etli) |
PF01382(Avidin) | 4 | THR A 120THR A 100THR A 64ASN A 92 | None | 1.39A | 4pgfB-3ew2A:undetectable | 4pgfB-3ew2A:14.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fve | DIAMINOPIMELATEEPIMERASE (Mycobacteriumtuberculosis) |
PF01678(DAP_epimerase) | 4 | THR A 262THR A 265THR A 121HIS A 123 | NoneNoneNoneGOL A 292 (-4.2A) | 1.17A | 4pgfB-3fveA:undetectable | 4pgfB-3fveA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fvr | ACETYL XYLANESTERASE (Bacilluspumilus) |
PF05448(AXE1) | 4 | THR A 244THR A 129HIS A 133ASN A 232 | None | 1.35A | 4pgfB-3fvrA:4.5 | 4pgfB-3fvrA:23.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 54THR A 57THR A 156HIS A 300ASN A 345 | ADN A 438 (-2.8A)ADN A 438 (-4.6A)NAD A 439 ( 3.0A)ADN A 438 ( 4.0A)NAD A 439 (-3.1A) | 0.31A | 4pgfB-3g1uA:31.3 | 4pgfB-3g1uA:70.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 156THR A 157THR A 273ASN A 345 | NAD A 439 ( 3.0A)NAD A 439 (-3.2A)NoneNAD A 439 (-3.1A) | 1.38A | 4pgfB-3g1uA:31.3 | 4pgfB-3g1uA:70.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g87 | MALONYL COA-ACYLCARRIER PROTEINTRANSACYLASE (Burkholderiapseudomallei) |
PF00698(Acyl_transf_1) | 4 | THR A 62THR A 59HIS A 91ASN A 70 | None | 1.27A | 4pgfB-3g87A:undetectable | 4pgfB-3g87A:20.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 64THR A 67THR A 200HIS A 344ASN A 387 | RAB A 602 (-2.7A)RAB A 602 (-4.5A)NAD A 601 ( 2.9A)RAB A 602 ( 3.5A)NAD A 601 (-3.0A) | 0.31A | 4pgfB-3glqA:58.2 | 4pgfB-3glqA:56.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 200THR A 201THR A 317ASN A 387 | NAD A 601 ( 2.9A)NAD A 601 (-3.1A)NoneNAD A 601 (-3.0A) | 1.40A | 4pgfB-3glqA:58.2 | 4pgfB-3glqA:56.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h9u | ADENOSYLHOMOCYSTEINASE (Trypanosomabrucei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 54THR A 57THR A 156HIS A 300ASN A 345 | ADN A 439 (-2.7A)ADN A 439 (-4.7A)NAD A 438 (-3.8A)NoneNAD A 438 (-2.9A) | 0.40A | 4pgfB-3h9uA:62.4 | 4pgfB-3h9uA:71.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h9u | ADENOSYLHOMOCYSTEINASE (Trypanosomabrucei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 156THR A 157THR A 273ASN A 345 | NAD A 438 (-3.8A)NAD A 438 (-3.2A)NoneNAD A 438 (-2.9A) | 1.40A | 4pgfB-3h9uA:62.4 | 4pgfB-3h9uA:71.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hn7 | UDP-N-ACETYLMURAMATE-L-ALANINE LIGASE (Psychrobacterarcticus) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 4 | THR A 117THR A 118HIS A 377ASN A 205 | None | 1.31A | 4pgfB-3hn7A:4.8 | 4pgfB-3hn7A:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iuu | PUTATIVEMETALLOPEPTIDASE (Chelativoranssp. BNC1) |
PF07171(MlrC_C)PF07364(DUF1485) | 4 | THR A 460THR A 23HIS A 13ASN A 413 | None | 1.15A | 4pgfB-3iuuA:3.9 | 4pgfB-3iuuA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iyl | VP1 (Aquareovirus C) |
PF06016(Reovirus_L2) | 4 | THR W1031THR W1032HIS W 989ASN W 825 | None | 1.37A | 4pgfB-3iylW:3.6 | 4pgfB-3iylW:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khy | PROPIONATE KINASE (Francisellatularensis) |
PF00871(Acetate_kinase) | 4 | THR A 370THR A 320THR A 218HIS A 146 | None | 1.21A | 4pgfB-3khyA:2.4 | 4pgfB-3khyA:22.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n58 | ADENOSYLHOMOCYSTEINASE (Brucellaabortus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 57THR A 60THR A 193HIS A 337ASN A 380 | ADN A 500 (-2.8A)ADN A 500 (-4.6A)NAD A 550 ( 3.0A)ADN A 500 ( 3.6A)NAD A 550 (-3.0A) | 0.32A | 4pgfB-3n58A:29.9 | 4pgfB-3n58A:58.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n58 | ADENOSYLHOMOCYSTEINASE (Brucellaabortus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 193THR A 194THR A 310ASN A 380 | NAD A 550 ( 3.0A)NAD A 550 (-3.0A)NoneNAD A 550 (-3.0A) | 1.35A | 4pgfB-3n58A:29.9 | 4pgfB-3n58A:58.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n5m | ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE (Bacillusanthracis) |
PF00202(Aminotran_3) | 4 | THR A 293THR A 278THR A 150ASN A 316 | None | 1.13A | 4pgfB-3n5mA:undetectable | 4pgfB-3n5mA:23.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 64THR A 67THR A 206HIS A 350ASN A 397 | ADE A 506 (-2.8A)ADE A 506 (-4.5A)NAD A 501 (-2.8A)NoneNAD A 501 (-3.0A) | 0.32A | 4pgfB-3oneA:54.7 | 4pgfB-3oneA:55.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pl2 | SUGAR KINASE,RIBOKINASE FAMILY (Corynebacteriumglutamicum) |
PF00294(PfkB) | 4 | THR A 141THR A 143THR A 97ASN A 45 | None | 1.36A | 4pgfB-3pl2A:5.0 | 4pgfB-3pl2A:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q6v | BETA-LACTAMASE (Serratiafonticola) |
PF00753(Lactamase_B) | 4 | THR A 88THR A 91HIS A 263ASN A 161 | NoneNone ZN A 2 ( 3.3A)None | 1.14A | 4pgfB-3q6vA:undetectable | 4pgfB-3q6vA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qef | BETA-XYLOSIDASE/ALPHA-L-ARABINFURANOSIDASE, GLY43N (Cellvibriojaponicus) |
PF04616(Glyco_hydro_43) | 4 | THR A 214THR A 263HIS A 282ASN A 257 | AHR A 337 (-4.7A)NoneNoneNone | 1.30A | 4pgfB-3qefA:undetectable | 4pgfB-3qefA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r31 | BETAINE ALDEHYDEDEHYDROGENASE (Agrobacteriumfabrum) |
PF00171(Aldedh) | 4 | THR A 443THR A 256HIS A 477ASN A 470 | None | 1.03A | 4pgfB-3r31A:2.5 | 4pgfB-3r31A:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3slc | ACETATE KINASE (Salmonellaenterica) |
PF00871(Acetate_kinase) | 4 | THR A 385THR A 331THR A 228HIS A 154 | None | 1.29A | 4pgfB-3slcA:undetectable | 4pgfB-3slcA:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t8j | PURINE NUCLEOSIDASE,(IUNH-1) (Sulfolobussolfataricus) |
PF01156(IU_nuc_hydro) | 4 | THR A 241THR A 242THR A 10ASN A 164 | NoneNoneNone NA A 401 ( 4.7A) | 1.33A | 4pgfB-3t8jA:7.8 | 4pgfB-3t8jA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ccd | GALACTOCEREBROSIDASE (Mus musculus) |
PF02057(Glyco_hydro_59)PF17387(Glyco_hydro_59M) | 4 | THR A 451THR A 449HIS A 80ASN A 74 | None | 1.30A | 4pgfB-4ccdA:undetectable | 4pgfB-4ccdA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dpp | DIHYDRODIPICOLINATESYNTHASE 2,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00701(DHDPS) | 4 | THR A 60THR A 152HIS A 165ASN A 215 | None | 1.39A | 4pgfB-4dppA:undetectable | 4pgfB-4dppA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fus | RTX TOXINS ANDRELATED CA2+-BINDINGPROTEIN (Hahellachejuensis) |
PF02011(Glyco_hydro_48) | 4 | THR A 217THR A 219THR A 81HIS A 64 | NoneNoneACT A 812 ( 3.9A)CBI A 802 (-4.4A) | 1.32A | 4pgfB-4fusA:undetectable | 4pgfB-4fusA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fwm | PROPIONATE KINASE (Salmonellaenterica) |
PF00871(Acetate_kinase) | 4 | THR A 379THR A 324THR A 221HIS A 147 | None | 1.19A | 4pgfB-4fwmA:2.8 | 4pgfB-4fwmA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ijr | D-ARABINOSEDEHYDROGENASE[NAD(P)+] HEAVYCHAIN (Saccharomycescerevisiae) |
PF00248(Aldo_ket_red) | 4 | THR A 50THR A 73THR A 98HIS A 64 | None | 1.40A | 4pgfB-4ijrA:undetectable | 4pgfB-4ijrA:24.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lan | URACIL-5-CARBOXYLATEDECARBOXYLASE (Cordycepsmilitaris) |
PF04909(Amidohydro_2) | 4 | THR A 13THR A 322THR A 86HIS A 82 | None | 1.19A | 4pgfB-4lanA:undetectable | 4pgfB-4lanA:22.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 60THR A 63THR A 198HIS A 342ASN A 385 | ADN A 501 (-2.8A)ADN A 501 (-4.5A)NAD A 503 ( 2.9A)ADN A 501 ( 3.7A)NAD A 503 (-3.1A) | 0.26A | 4pgfB-4lvcA:57.4 | 4pgfB-4lvcA:57.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 198THR A 199THR A 315ASN A 385 | NAD A 503 ( 2.9A)NAD A 503 (-2.9A)NoneNAD A 503 (-3.1A) | 1.38A | 4pgfB-4lvcA:57.4 | 4pgfB-4lvcA:57.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lvu | OXIDOREDUCTASE,SHORT CHAINDEHYDROGENASE/REDUCTASE FAMILY (Burkholderiathailandensis) |
PF13561(adh_short_C2) | 4 | THR A 189THR A 205THR A 35HIS A 140 | None | 1.33A | 4pgfB-4lvuA:9.8 | 4pgfB-4lvuA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m1r | CELLULASE 5 (soil metagenome) |
PF00150(Cellulase) | 4 | THR A 237THR A 234THR A 282ASN A 253 | None | 1.25A | 4pgfB-4m1rA:undetectable | 4pgfB-4m1rA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mso | SERINEHYDROXYMETHYLTRANSFERASE (Burkholderiacenocepacia) |
PF00464(SHMT) | 4 | THR A 227THR A 226HIS A 315ASN A 38 | PO4 A 501 (-4.1A)NoneNoneNone | 1.41A | 4pgfB-4msoA:3.6 | 4pgfB-4msoA:23.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nur | PSDSA (Pseudomonas sp.S9) |
PF00753(Lactamase_B)PF14863(Alkyl_sulf_dimr)PF14864(Alkyl_sulf_C) | 4 | THR A 325THR A 327THR A 264ASN A 147 | None | 1.40A | 4pgfB-4nurA:undetectable | 4pgfB-4nurA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p0d | TRYPSIN-RESISTANTSURFACE T6 PROTEIN (Streptococcuspyogenes) |
PF16569(GramPos_pilinBB) | 4 | THR A 53THR A 107THR A 99ASN A 318 | None | 1.33A | 4pgfB-4p0dA:undetectable | 4pgfB-4p0dA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pd3 | NONMUSCLE MYOSINHEAVY CHAIN B,ALPHA-ACTININ ACHIMERA PROTEIN (Dictyosteliumdiscoideum;Homo sapiens) |
PF00063(Myosin_head)PF00435(Spectrin)PF02736(Myosin_N) | 4 | THR A 185THR A 188THR A 263ASN A 230 | None | 1.02A | 4pgfB-4pd3A:undetectable | 4pgfB-4pd3A:17.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rxe | FARNESYLPYROPHOSPHATESYNTHASE (Trypanosomabrucei) |
PF00348(polyprenyl_synt) | 4 | THR A 167THR A 168THR A 140HIS A 141 | None | 1.35A | 4pgfB-4rxeA:undetectable | 4pgfB-4rxeA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tvc | DEXTRANSUCRASE (Leuconostocmesenteroides) |
PF02324(Glyco_hydro_70) | 4 | THR A1798THR A1797THR A1979HIS A2818 | NoneTYI A2075 ( 4.8A)NoneNone | 1.29A | 4pgfB-4tvcA:undetectable | 4pgfB-4tvcA:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tvc | DEXTRANSUCRASE (Leuconostocmesenteroides) |
PF02324(Glyco_hydro_70) | 4 | THR A2571THR A2570THR A2566ASN A2309 | None | 1.26A | 4pgfB-4tvcA:undetectable | 4pgfB-4tvcA:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u6h | PROTEIN L1 (Vaccinia virus) |
PF02442(L1R_F9L) | 4 | THR E 167THR E 168THR E 52ASN E 12 | None | 1.19A | 4pgfB-4u6hE:undetectable | 4pgfB-4u6hE:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4unf | ENDONUCLEASE III-1 (Deinococcusradiodurans) |
PF00730(HhH-GPD) | 4 | THR A 56THR A 44HIS A 206ASN A 157 | None | 1.25A | 4pgfB-4unfA:undetectable | 4pgfB-4unfA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zxz | LEVOGLUCOSAN KINASE (Lipomycesstarkeyi) |
PF03702(AnmK) | 4 | THR A 116THR A 133THR A 365HIS A 167 | None | 1.41A | 4pgfB-4zxzA:undetectable | 4pgfB-4zxzA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ahu | FARNESYLPYROPHOSPHATESYNTHASE (Trypanosomabrucei) |
PF00348(polyprenyl_synt) | 4 | THR B 167THR B 168THR B 140HIS B 141 | None | 1.42A | 4pgfB-5ahuB:undetectable | 4pgfB-5ahuB:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cef | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Cryptococcusneoformans) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 4 | THR A 159THR A 158HIS A 132ASN A 354 | None | 0.94A | 4pgfB-5cefA:3.0 | 4pgfB-5cefA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d8g | TRYPTOPHANASE (Escherichiacoli) |
PF01212(Beta_elim_lyase) | 4 | THR A 139THR A 138HIS A 358ASN A 133 | None | 1.41A | 4pgfB-5d8gA:2.8 | 4pgfB-5d8gA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dz6 | POLYKETIDEBIOSYNTHESIS MALONYLCOA-ACYL CARRIERPROTEIN TRANSACYLASEPKSC (Bacillussubtilis) |
PF00698(Acyl_transf_1) | 4 | THR A 57THR A 54HIS A 86ASN A 65 | CL A 305 ( 4.0A) CL A 305 (-4.2A)GOL A 301 (-4.7A)None | 1.30A | 4pgfB-5dz6A:undetectable | 4pgfB-5dz6A:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dz7 | POLYKETIDEBIOSYNTHESIS PROTEINPKSE (Bacillussubtilis) |
PF00698(Acyl_transf_1) | 4 | THR A 57THR A 54HIS A 86ASN A 65 | None | 1.31A | 4pgfB-5dz7A:undetectable | 4pgfB-5dz7A:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jmu | PEPTIDOGLYCANN-ACETYLGLUCOSAMINEDEACETYLASE ([Eubacterium]rectale) |
PF01522(Polysacc_deac_1) | 4 | THR A 295THR A 319HIS A 491ASN A 421 | None | 1.05A | 4pgfB-5jmuA:undetectable | 4pgfB-5jmuA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5joz | NON-REDUCING ENDALPHA-L-ARABINOFURANOSIDASE BOGH43B (Bacteroidesovatus) |
PF04616(Glyco_hydro_43) | 4 | THR A 426THR A 439HIS A 420ASN A 510 | None | 1.42A | 4pgfB-5jozA:undetectable | 4pgfB-5jozA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l9w | ACETOPHENONECARBOXYLASE GAMMASUBUNIT (Aromatoleumaromaticum) |
PF01968(Hydantoinase_A)PF05378(Hydant_A_N) | 4 | THR B 39THR B 22THR B 280ASN B 82 | None | 1.37A | 4pgfB-5l9wB:3.7 | 4pgfB-5l9wB:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ngk | GLUCOSYLCERAMIDASE (Bacteroidesthetaiotaomicron) |
PF02055(Glyco_hydro_30)PF17189(Glyco_hydro_30C) | 4 | THR A 92THR A 89THR A 340HIS A 415 | None | 1.35A | 4pgfB-5ngkA:undetectable | 4pgfB-5ngkA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nz7 | CELLODEXTRINPHOSPHORYLASE (Ruminiclostridiumthermocellum) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 4 | THR A 281THR A 283THR A 364HIS A 367 | None | 1.08A | 4pgfB-5nz7A:undetectable | 4pgfB-5nz7A:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oei | UNCHARACTERIZEDPROTEIN FAMILYUPF0065:TAT PATHWAYSIGNAL (Rhodopseudomonaspalustris) |
no annotation | 4 | THR A 53THR A 54THR A 110ASN A 137 | NoneOOG A 401 (-3.6A)NoneOOG A 401 ( 4.8A) | 1.22A | 4pgfB-5oeiA:undetectable | 4pgfB-5oeiA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5swc | CARBONIC ANHYDRASE (Synechocystissp. PCC 6803) |
PF00484(Pro_CA) | 4 | THR A 127THR A 130HIS A 98ASN A 62 | NoneNone ZN A 301 (-3.3A)None | 1.30A | 4pgfB-5swcA:undetectable | 4pgfB-5swcA:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tf2 | PROLACTIN REGULATORYELEMENT-BINDINGPROTEIN (Homo sapiens) |
PF00400(WD40) | 4 | THR A 283THR A 266THR A 229HIS A 232 | None | 1.37A | 4pgfB-5tf2A:undetectable | 4pgfB-5tf2A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ukh | UNCHARACTERIZEDPROTEIN (Streptococcusintermedius) |
no annotation | 4 | THR A 441THR A 440THR A 408HIS A 412 | None | 1.32A | 4pgfB-5ukhA:undetectable | 4pgfB-5ukhA:21.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5utu | ADENOSYLHOMOCYSTEINASE (Cryptosporidiumparvum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 55THR A 58THR A 212ASN A 403 | SAH A 502 (-2.7A)SAH A 502 (-4.2A)NAD A 501 ( 4.1A)NAD A 501 (-2.9A) | 0.41A | 4pgfB-5utuA:52.5 | 4pgfB-5utuA:47.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5v96 | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE (Naegleriafowleri) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 61THR A 64THR A 198ASN A 388 | ADN A 502 (-2.9A)ADN A 502 (-4.4A)NAD A 501 ( 2.9A)NAD A 501 (-3.1A) | 0.30A | 4pgfB-5v96A:56.3 | 4pgfB-5v96A:56.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xeo | CYSTEINE SYNTHASE (Fusobacteriumnucleatum) |
no annotation | 4 | THR A 270THR A 267THR A 156HIS A 152 | None | 1.38A | 4pgfB-5xeoA:2.6 | 4pgfB-5xeoA:14.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yp3 | DIPEPTIDYLAMINOPEPTIDASE 4 (Pseudoxanthomonasmexicana) |
no annotation | 4 | THR A 450THR A 451THR A 425HIS A 410 | None | 1.42A | 4pgfB-5yp3A:undetectable | 4pgfB-5yp3A:11.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6apg | DISD PROTEIN (Sorangiumcellulosum) |
no annotation | 4 | THR A 57THR A 54HIS A 85ASN A 65 | NoneNoneMLI A 301 (-4.7A)None | 1.28A | 4pgfB-6apgA:undetectable | 4pgfB-6apgA:11.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6aph | ADENOSYLHOMOCYSTEINASE (Elizabethkingiaanophelis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 60THR A 63THR A 162HIS A 306ASN A 351 | ADN A 501 (-2.8A)ADN A 501 (-4.5A)NAD A 500 ( 2.9A)ADN A 501 ( 3.7A)NAD A 500 (-3.1A) | 0.28A | 4pgfB-6aphA:62.5 | 4pgfB-6aphA:66.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6aph | ADENOSYLHOMOCYSTEINASE (Elizabethkingiaanophelis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 162THR A 163THR A 279ASN A 351 | NAD A 500 ( 2.9A)NAD A 500 (-3.1A)NoneNAD A 500 (-3.1A) | 1.40A | 4pgfB-6aphA:62.5 | 4pgfB-6aphA:66.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6aph | ADENOSYLHOMOCYSTEINASE (Elizabethkingiaanophelis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 164THR A 163THR A 233ASN A 303 | NAD A 500 (-3.7A)NAD A 500 (-3.1A)NoneNone | 1.42A | 4pgfB-6aphA:62.5 | 4pgfB-6aphA:66.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b8d | ELONGATION FACTOR G (Haemophilusinfluenzae) |
no annotation | 4 | THR A 5THR A 4HIS A 365ASN A 85 | None | 1.18A | 4pgfB-6b8dA:2.3 | 4pgfB-6b8dA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f3m | - (-) |
no annotation | 5 | THR B 63THR B 66THR B 165HIS B 323ASN B 375 | ADN B 502 (-2.8A)ADN B 502 (-4.6A)NAD B 501 ( 2.8A) ZN B 505 (-3.2A)NAD B 501 (-3.0A) | 0.31A | 4pgfB-6f3mB:56.2 | 4pgfB-6f3mB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f3m | - (-) |
no annotation | 4 | THR B 165THR B 166THR B 296ASN B 375 | NAD B 501 ( 2.8A)NAD B 501 (-3.1A)NoneNAD B 501 (-3.0A) | 1.38A | 4pgfB-6f3mB:56.2 | 4pgfB-6f3mB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbn | - (-) |
no annotation | 5 | THR A 58THR A 61THR A 160HIS A 304ASN A 349 | ADN A 501 (-2.8A)ADN A 501 (-4.6A)NAD A 502 ( 2.8A)ADN A 501 ( 3.6A)NAD A 502 (-3.1A) | 0.28A | 4pgfB-6gbnA:62.6 | 4pgfB-6gbnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbn | - (-) |
no annotation | 4 | THR A 160THR A 161THR A 277ASN A 349 | NAD A 502 ( 2.8A)NAD A 502 (-3.1A)NoneNAD A 502 (-3.1A) | 1.39A | 4pgfB-6gbnA:62.6 | 4pgfB-6gbnA:undetectable |