SIMILAR PATTERNS OF AMINO ACIDS FOR 4PGF_B_ADNB502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis)
PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5)
4 THR A 149
THR A 211
THR A  72
ASN A  21
None
1.38A 4pgfB-1dgsA:
undetectable
4pgfB-1dgsA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE


(Lactobacillus
casei)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
4 THR A 264
THR A 212
HIS A 213
ASN A 231
None
1.40A 4pgfB-1dxyA:
4.5
4pgfB-1dxyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE


(Escherichia
coli)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
4 THR A 122
THR A 123
HIS A 359
ASN A 205
None
None
API  A1499 (-3.7A)
None
1.28A 4pgfB-1e8cA:
2.6
4pgfB-1e8cA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eq2 ADP-L-GLYCERO-D-MANN
OHEPTOSE 6-EPIMERASE


(Escherichia
coli)
PF01370
(Epimerase)
4 THR A  81
THR A  82
HIS A 187
ASN A 169
ADQ  A2500 (-4.0A)
None
ADQ  A2500 (-3.8A)
ADQ  A2500 (-3.7A)
1.16A 4pgfB-1eq2A:
6.3
4pgfB-1eq2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE


(Hydrogenophaga
pseudoflava)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
4 THR B 519
THR B 561
THR B 650
HIS B 748
None
PCD  B1920 ( 4.3A)
None
None
1.33A 4pgfB-1ffvB:
undetectable
4pgfB-1ffvB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays)
PF00232
(Glyco_hydro_1)
4 THR A 400
THR A 183
HIS A 233
ASN A 321
None
1.43A 4pgfB-1hxjA:
undetectable
4pgfB-1hxjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN


(Oligotropha
carboxidovorans)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
4 THR B 525
THR B 567
THR B 656
HIS B 754
None
MCN  B4920 (-3.8A)
None
None
1.19A 4pgfB-1n60B:
undetectable
4pgfB-1n60B:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odt CEPHALOSPORIN C
DEACETYLASE


(Bacillus
subtilis)
PF05448
(AXE1)
4 THR C 178
THR C 187
THR C 272
HIS C 298
None
None
None
ACT  C1318 (-4.0A)
1.35A 4pgfB-1odtC:
4.4
4pgfB-1odtC:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuu ACETATE KINASE

(Methanosarcina
thermophila)
PF00871
(Acetate_kinase)
4 THR A 382
THR A 329
THR A 226
HIS A 152
None
1.28A 4pgfB-1tuuA:
undetectable
4pgfB-1tuuA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
4 THR A 284
THR A 305
THR A   7
ASN A 328
THR  A 284 ( 0.8A)
THR  A 305 ( 0.8A)
THR  A   7 ( 0.8A)
ASN  A 328 ( 0.6A)
1.35A 4pgfB-1wqaA:
2.4
4pgfB-1wqaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4j SULFATASE MODIFYING
FACTOR 2


(Homo sapiens)
PF03781
(FGE-sulfatase)
4 THR A 238
THR A 273
HIS A 267
ASN A 285
None
1.42A 4pgfB-1y4jA:
undetectable
4pgfB-1y4jA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens)
PF00245
(Alk_phosphatase)
4 THR A 149
THR A 147
THR A  95
HIS A 358
MG  A 903 ( 4.6A)
None
SEP  A  92 ( 4.1A)
ZN  A 902 (-3.2A)
1.31A 4pgfB-1zefA:
undetectable
4pgfB-1zefA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iir ACETATE KINASE

(Thermotoga
maritima)
PF00871
(Acetate_kinase)
4 THR A 384
THR A 329
THR A 225
HIS A 151
None
1.18A 4pgfB-2iirA:
undetectable
4pgfB-2iirA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilx 2',3'-CYCLIC-NUCLEOT
IDE
3'-PHOSPHODIESTERASE


(Rattus
norvegicus)
PF05881
(CNPase)
4 THR A 115
THR A 164
THR A  73
HIS A  71
None
1.21A 4pgfB-2ilxA:
undetectable
4pgfB-2ilxA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jmr FIMF

(Escherichia
coli)
PF00419
(Fimbrial)
4 THR A 140
THR A 135
HIS A  75
ASN A  84
None
1.40A 4pgfB-2jmrA:
undetectable
4pgfB-2jmrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE


(Escherichia
coli)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 THR A 340
THR A 339
HIS A 256
ASN A 349
None
1.34A 4pgfB-2q27A:
4.5
4pgfB-2q27A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE


(Streptomyces)
PF01494
(FAD_binding_3)
4 THR A  47
THR A  50
HIS A 278
ASN A 332
None
1.27A 4pgfB-2qa2A:
undetectable
4pgfB-2qa2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5v PCZA361.1

(Amycolatopsis
orientalis)
PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5)
4 THR A 113
THR A 125
THR A  55
HIS A  40
None
1.30A 4pgfB-2r5vA:
undetectable
4pgfB-2r5vA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans)
PF14498
(Glyco_hyd_65N_2)
4 THR A 272
THR A 269
THR A  44
ASN A  22
None
1.19A 4pgfB-2rdyA:
undetectable
4pgfB-2rdyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX


(Sulfolobus
solfataricus)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48)
4 THR A 329
THR A 327
HIS A 470
ASN A 240
A16  A1722 ( 4.4A)
None
A16  A1722 (-4.0A)
None
1.34A 4pgfB-2vr5A:
undetectable
4pgfB-2vr5A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x86 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E


(Escherichia
coli)
PF01370
(Epimerase)
4 THR A  81
THR A  82
HIS A 187
ASN A 169
ADP  A 401 ( 3.7A)
None
ADP  A 401 (-4.1A)
ADP  A 401 (-3.9A)
1.22A 4pgfB-2x86A:
5.7
4pgfB-2x86A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 THR A 100
THR A 123
THR A  75
ASN A 312
None
1.25A 4pgfB-2xf2A:
4.8
4pgfB-2xf2A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF00171
(Aldedh)
4 THR A 438
THR A 252
HIS A 471
ASN A 464
None
None
GOL  A 603 (-3.7A)
None
1.22A 4pgfB-3b4wA:
3.3
4pgfB-3b4wA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfg CLASS A
BETA-LACTAMASE SED1


(Citrobacter
sedlakii)
PF13354
(Beta-lactamase2)
4 THR A 103
THR A 133
THR A  76
ASN A 170
None
None
None
MER  A 301 (-2.6A)
1.36A 4pgfB-3bfgA:
undetectable
4pgfB-3bfgA:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE


(Mycobacterium
tuberculosis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A  71
THR A  74
THR A 219
HIS A 363
ASN A 409
ADN  A 500 (-2.8A)
ADN  A 500 (-4.5A)
NAD  A 550 ( 2.8A)
ADN  A 500 ( 3.7A)
NAD  A 550 (-3.0A)
0.32A 4pgfB-3ce6A:
55.4
4pgfB-3ce6A:
54.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE


(Mycobacterium
tuberculosis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 THR A 219
THR A 220
THR A 336
ASN A 409
NAD  A 550 ( 2.8A)
NAD  A 550 (-3.1A)
None
NAD  A 550 (-3.0A)
1.36A 4pgfB-3ce6A:
55.4
4pgfB-3ce6A:
54.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE


(Mycobacterium
tuberculosis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 THR A 221
THR A 219
THR A 257
ASN A 360
NAD  A 550 (-3.7A)
NAD  A 550 ( 2.8A)
None
None
1.31A 4pgfB-3ce6A:
55.4
4pgfB-3ce6A:
54.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE


(Mycobacterium
tuberculosis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 THR A 257
THR A 221
HIS A 363
ASN A 360
None
NAD  A 550 (-3.7A)
ADN  A 500 ( 3.7A)
None
1.06A 4pgfB-3ce6A:
55.4
4pgfB-3ce6A:
54.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5z PUTATIVE
GLUCONOLACTONASE


(Deinococcus
radiodurans)
PF08450
(SGL)
4 THR A 274
THR A 258
THR A 190
ASN A  72
None
None
None
MG  A 297 ( 4.4A)
1.24A 4pgfB-3e5zA:
undetectable
4pgfB-3e5zA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ew2 RHIZAVIDIN

(Rhizobium etli)
PF01382
(Avidin)
4 THR A 120
THR A 100
THR A  64
ASN A  92
None
1.39A 4pgfB-3ew2A:
undetectable
4pgfB-3ew2A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fve DIAMINOPIMELATE
EPIMERASE


(Mycobacterium
tuberculosis)
PF01678
(DAP_epimerase)
4 THR A 262
THR A 265
THR A 121
HIS A 123
None
None
None
GOL  A 292 (-4.2A)
1.17A 4pgfB-3fveA:
undetectable
4pgfB-3fveA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvr ACETYL XYLAN
ESTERASE


(Bacillus
pumilus)
PF05448
(AXE1)
4 THR A 244
THR A 129
HIS A 133
ASN A 232
None
1.35A 4pgfB-3fvrA:
4.5
4pgfB-3fvrA:
23.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE


(Leishmania
major)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A  54
THR A  57
THR A 156
HIS A 300
ASN A 345
ADN  A 438 (-2.8A)
ADN  A 438 (-4.6A)
NAD  A 439 ( 3.0A)
ADN  A 438 ( 4.0A)
NAD  A 439 (-3.1A)
0.31A 4pgfB-3g1uA:
31.3
4pgfB-3g1uA:
70.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE


(Leishmania
major)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 THR A 156
THR A 157
THR A 273
ASN A 345
NAD  A 439 ( 3.0A)
NAD  A 439 (-3.2A)
None
NAD  A 439 (-3.1A)
1.38A 4pgfB-3g1uA:
31.3
4pgfB-3g1uA:
70.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g87 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE


(Burkholderia
pseudomallei)
PF00698
(Acyl_transf_1)
4 THR A  62
THR A  59
HIS A  91
ASN A  70
None
1.27A 4pgfB-3g87A:
undetectable
4pgfB-3g87A:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE


(Burkholderia
pseudomallei)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A  64
THR A  67
THR A 200
HIS A 344
ASN A 387
RAB  A 602 (-2.7A)
RAB  A 602 (-4.5A)
NAD  A 601 ( 2.9A)
RAB  A 602 ( 3.5A)
NAD  A 601 (-3.0A)
0.31A 4pgfB-3glqA:
58.2
4pgfB-3glqA:
56.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE


(Burkholderia
pseudomallei)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 THR A 200
THR A 201
THR A 317
ASN A 387
NAD  A 601 ( 2.9A)
NAD  A 601 (-3.1A)
None
NAD  A 601 (-3.0A)
1.40A 4pgfB-3glqA:
58.2
4pgfB-3glqA:
56.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h9u ADENOSYLHOMOCYSTEINA
SE


(Trypanosoma
brucei)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A  54
THR A  57
THR A 156
HIS A 300
ASN A 345
ADN  A 439 (-2.7A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
NAD  A 438 (-2.9A)
0.40A 4pgfB-3h9uA:
62.4
4pgfB-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h9u ADENOSYLHOMOCYSTEINA
SE


(Trypanosoma
brucei)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 THR A 156
THR A 157
THR A 273
ASN A 345
NAD  A 438 (-3.8A)
NAD  A 438 (-3.2A)
None
NAD  A 438 (-2.9A)
1.40A 4pgfB-3h9uA:
62.4
4pgfB-3h9uA:
71.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE


(Psychrobacter
arcticus)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
4 THR A 117
THR A 118
HIS A 377
ASN A 205
None
1.31A 4pgfB-3hn7A:
4.8
4pgfB-3hn7A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuu PUTATIVE
METALLOPEPTIDASE


(Chelativorans
sp. BNC1)
PF07171
(MlrC_C)
PF07364
(DUF1485)
4 THR A 460
THR A  23
HIS A  13
ASN A 413
None
1.15A 4pgfB-3iuuA:
3.9
4pgfB-3iuuA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C)
PF06016
(Reovirus_L2)
4 THR W1031
THR W1032
HIS W 989
ASN W 825
None
1.37A 4pgfB-3iylW:
3.6
4pgfB-3iylW:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khy PROPIONATE KINASE

(Francisella
tularensis)
PF00871
(Acetate_kinase)
4 THR A 370
THR A 320
THR A 218
HIS A 146
None
1.21A 4pgfB-3khyA:
2.4
4pgfB-3khyA:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n58 ADENOSYLHOMOCYSTEINA
SE


(Brucella
abortus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A  57
THR A  60
THR A 193
HIS A 337
ASN A 380
ADN  A 500 (-2.8A)
ADN  A 500 (-4.6A)
NAD  A 550 ( 3.0A)
ADN  A 500 ( 3.6A)
NAD  A 550 (-3.0A)
0.32A 4pgfB-3n58A:
29.9
4pgfB-3n58A:
58.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n58 ADENOSYLHOMOCYSTEINA
SE


(Brucella
abortus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 THR A 193
THR A 194
THR A 310
ASN A 380
NAD  A 550 ( 3.0A)
NAD  A 550 (-3.0A)
None
NAD  A 550 (-3.0A)
1.35A 4pgfB-3n58A:
29.9
4pgfB-3n58A:
58.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5m ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE


(Bacillus
anthracis)
PF00202
(Aminotran_3)
4 THR A 293
THR A 278
THR A 150
ASN A 316
None
1.13A 4pgfB-3n5mA:
undetectable
4pgfB-3n5mA:
23.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE


(Lupinus luteus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A  64
THR A  67
THR A 206
HIS A 350
ASN A 397
ADE  A 506 (-2.8A)
ADE  A 506 (-4.5A)
NAD  A 501 (-2.8A)
None
NAD  A 501 (-3.0A)
0.32A 4pgfB-3oneA:
54.7
4pgfB-3oneA:
55.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl2 SUGAR KINASE,
RIBOKINASE FAMILY


(Corynebacterium
glutamicum)
PF00294
(PfkB)
4 THR A 141
THR A 143
THR A  97
ASN A  45
None
1.36A 4pgfB-3pl2A:
5.0
4pgfB-3pl2A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6v BETA-LACTAMASE

(Serratia
fonticola)
PF00753
(Lactamase_B)
4 THR A  88
THR A  91
HIS A 263
ASN A 161
None
None
ZN  A   2 ( 3.3A)
None
1.14A 4pgfB-3q6vA:
undetectable
4pgfB-3q6vA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qef BETA-XYLOSIDASE/ALPH
A-L-ARABINFURANOSIDA
SE, GLY43N


(Cellvibrio
japonicus)
PF04616
(Glyco_hydro_43)
4 THR A 214
THR A 263
HIS A 282
ASN A 257
AHR  A 337 (-4.7A)
None
None
None
1.30A 4pgfB-3qefA:
undetectable
4pgfB-3qefA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r31 BETAINE ALDEHYDE
DEHYDROGENASE


(Agrobacterium
fabrum)
PF00171
(Aldedh)
4 THR A 443
THR A 256
HIS A 477
ASN A 470
None
1.03A 4pgfB-3r31A:
2.5
4pgfB-3r31A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slc ACETATE KINASE

(Salmonella
enterica)
PF00871
(Acetate_kinase)
4 THR A 385
THR A 331
THR A 228
HIS A 154
None
1.29A 4pgfB-3slcA:
undetectable
4pgfB-3slcA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8j PURINE NUCLEOSIDASE,
(IUNH-1)


(Sulfolobus
solfataricus)
PF01156
(IU_nuc_hydro)
4 THR A 241
THR A 242
THR A  10
ASN A 164
None
None
None
NA  A 401 ( 4.7A)
1.33A 4pgfB-3t8jA:
7.8
4pgfB-3t8jA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus)
PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M)
4 THR A 451
THR A 449
HIS A  80
ASN A  74
None
1.30A 4pgfB-4ccdA:
undetectable
4pgfB-4ccdA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00701
(DHDPS)
4 THR A  60
THR A 152
HIS A 165
ASN A 215
None
1.39A 4pgfB-4dppA:
undetectable
4pgfB-4dppA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN


(Hahella
chejuensis)
PF02011
(Glyco_hydro_48)
4 THR A 217
THR A 219
THR A  81
HIS A  64
None
None
ACT  A 812 ( 3.9A)
CBI  A 802 (-4.4A)
1.32A 4pgfB-4fusA:
undetectable
4pgfB-4fusA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwm PROPIONATE KINASE

(Salmonella
enterica)
PF00871
(Acetate_kinase)
4 THR A 379
THR A 324
THR A 221
HIS A 147
None
1.19A 4pgfB-4fwmA:
2.8
4pgfB-4fwmA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN


(Saccharomyces
cerevisiae)
PF00248
(Aldo_ket_red)
4 THR A  50
THR A  73
THR A  98
HIS A  64
None
1.40A 4pgfB-4ijrA:
undetectable
4pgfB-4ijrA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE


(Cordyceps
militaris)
PF04909
(Amidohydro_2)
4 THR A  13
THR A 322
THR A  86
HIS A  82
None
1.19A 4pgfB-4lanA:
undetectable
4pgfB-4lanA:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)


(Bradyrhizobium
elkanii)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A  60
THR A  63
THR A 198
HIS A 342
ASN A 385
ADN  A 501 (-2.8A)
ADN  A 501 (-4.5A)
NAD  A 503 ( 2.9A)
ADN  A 501 ( 3.7A)
NAD  A 503 (-3.1A)
0.26A 4pgfB-4lvcA:
57.4
4pgfB-4lvcA:
57.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)


(Bradyrhizobium
elkanii)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 THR A 198
THR A 199
THR A 315
ASN A 385
NAD  A 503 ( 2.9A)
NAD  A 503 (-2.9A)
None
NAD  A 503 (-3.1A)
1.38A 4pgfB-4lvcA:
57.4
4pgfB-4lvcA:
57.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvu OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY


(Burkholderia
thailandensis)
PF13561
(adh_short_C2)
4 THR A 189
THR A 205
THR A  35
HIS A 140
None
1.33A 4pgfB-4lvuA:
9.8
4pgfB-4lvuA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1r CELLULASE 5

(soil metagenome)
PF00150
(Cellulase)
4 THR A 237
THR A 234
THR A 282
ASN A 253
None
1.25A 4pgfB-4m1rA:
undetectable
4pgfB-4m1rA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mso SERINE
HYDROXYMETHYLTRANSFE
RASE


(Burkholderia
cenocepacia)
PF00464
(SHMT)
4 THR A 227
THR A 226
HIS A 315
ASN A  38
PO4  A 501 (-4.1A)
None
None
None
1.41A 4pgfB-4msoA:
3.6
4pgfB-4msoA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nur PSDSA

(Pseudomonas sp.
S9)
PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C)
4 THR A 325
THR A 327
THR A 264
ASN A 147
None
1.40A 4pgfB-4nurA:
undetectable
4pgfB-4nurA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN


(Streptococcus
pyogenes)
PF16569
(GramPos_pilinBB)
4 THR A  53
THR A 107
THR A  99
ASN A 318
None
1.33A 4pgfB-4p0dA:
undetectable
4pgfB-4p0dA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN


(Dictyostelium
discoideum;
Homo sapiens)
PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N)
4 THR A 185
THR A 188
THR A 263
ASN A 230
None
1.02A 4pgfB-4pd3A:
undetectable
4pgfB-4pd3A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE


(Trypanosoma
brucei)
PF00348
(polyprenyl_synt)
4 THR A 167
THR A 168
THR A 140
HIS A 141
None
1.35A 4pgfB-4rxeA:
undetectable
4pgfB-4rxeA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides)
PF02324
(Glyco_hydro_70)
4 THR A1798
THR A1797
THR A1979
HIS A2818
None
TYI  A2075 ( 4.8A)
None
None
1.29A 4pgfB-4tvcA:
undetectable
4pgfB-4tvcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides)
PF02324
(Glyco_hydro_70)
4 THR A2571
THR A2570
THR A2566
ASN A2309
None
1.26A 4pgfB-4tvcA:
undetectable
4pgfB-4tvcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6h PROTEIN L1

(Vaccinia virus)
PF02442
(L1R_F9L)
4 THR E 167
THR E 168
THR E  52
ASN E  12
None
1.19A 4pgfB-4u6hE:
undetectable
4pgfB-4u6hE:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4unf ENDONUCLEASE III-1

(Deinococcus
radiodurans)
PF00730
(HhH-GPD)
4 THR A  56
THR A  44
HIS A 206
ASN A 157
None
1.25A 4pgfB-4unfA:
undetectable
4pgfB-4unfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxz LEVOGLUCOSAN KINASE

(Lipomyces
starkeyi)
PF03702
(AnmK)
4 THR A 116
THR A 133
THR A 365
HIS A 167
None
1.41A 4pgfB-4zxzA:
undetectable
4pgfB-4zxzA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE


(Trypanosoma
brucei)
PF00348
(polyprenyl_synt)
4 THR B 167
THR B 168
THR B 140
HIS B 141
None
1.42A 4pgfB-5ahuB:
undetectable
4pgfB-5ahuB:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Cryptococcus
neoformans)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
4 THR A 159
THR A 158
HIS A 132
ASN A 354
None
0.94A 4pgfB-5cefA:
3.0
4pgfB-5cefA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli)
PF01212
(Beta_elim_lyase)
4 THR A 139
THR A 138
HIS A 358
ASN A 133
None
1.41A 4pgfB-5d8gA:
2.8
4pgfB-5d8gA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC


(Bacillus
subtilis)
PF00698
(Acyl_transf_1)
4 THR A  57
THR A  54
HIS A  86
ASN A  65
CL  A 305 ( 4.0A)
CL  A 305 (-4.2A)
GOL  A 301 (-4.7A)
None
1.30A 4pgfB-5dz6A:
undetectable
4pgfB-5dz6A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE


(Bacillus
subtilis)
PF00698
(Acyl_transf_1)
4 THR A  57
THR A  54
HIS A  86
ASN A  65
None
1.31A 4pgfB-5dz7A:
undetectable
4pgfB-5dz7A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmu PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE


([Eubacterium]
rectale)
PF01522
(Polysacc_deac_1)
4 THR A 295
THR A 319
HIS A 491
ASN A 421
None
1.05A 4pgfB-5jmuA:
undetectable
4pgfB-5jmuA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joz NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43B


(Bacteroides
ovatus)
PF04616
(Glyco_hydro_43)
4 THR A 426
THR A 439
HIS A 420
ASN A 510
None
1.42A 4pgfB-5jozA:
undetectable
4pgfB-5jozA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT


(Aromatoleum
aromaticum)
PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N)
4 THR B  39
THR B  22
THR B 280
ASN B  82
None
1.37A 4pgfB-5l9wB:
3.7
4pgfB-5l9wB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron)
PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C)
4 THR A  92
THR A  89
THR A 340
HIS A 415
None
1.35A 4pgfB-5ngkA:
undetectable
4pgfB-5ngkA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE


(Ruminiclostridium
thermocellum)
PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36)
4 THR A 281
THR A 283
THR A 364
HIS A 367
None
1.08A 4pgfB-5nz7A:
undetectable
4pgfB-5nz7A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oei UNCHARACTERIZED
PROTEIN FAMILY
UPF0065:TAT PATHWAY
SIGNAL


(Rhodopseudomonas
palustris)
no annotation 4 THR A  53
THR A  54
THR A 110
ASN A 137
None
OOG  A 401 (-3.6A)
None
OOG  A 401 ( 4.8A)
1.22A 4pgfB-5oeiA:
undetectable
4pgfB-5oeiA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swc CARBONIC ANHYDRASE

(Synechocystis
sp. PCC 6803)
PF00484
(Pro_CA)
4 THR A 127
THR A 130
HIS A  98
ASN A  62
None
None
ZN  A 301 (-3.3A)
None
1.30A 4pgfB-5swcA:
undetectable
4pgfB-5swcA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN


(Homo sapiens)
PF00400
(WD40)
4 THR A 283
THR A 266
THR A 229
HIS A 232
None
1.37A 4pgfB-5tf2A:
undetectable
4pgfB-5tf2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukh UNCHARACTERIZED
PROTEIN


(Streptococcus
intermedius)
no annotation 4 THR A 441
THR A 440
THR A 408
HIS A 412
None
1.32A 4pgfB-5ukhA:
undetectable
4pgfB-5ukhA:
21.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5utu ADENOSYLHOMOCYSTEINA
SE


(Cryptosporidium
parvum)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 THR A  55
THR A  58
THR A 212
ASN A 403
SAH  A 502 (-2.7A)
SAH  A 502 (-4.2A)
NAD  A 501 ( 4.1A)
NAD  A 501 (-2.9A)
0.41A 4pgfB-5utuA:
52.5
4pgfB-5utuA:
47.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE


(Naegleria
fowleri)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 THR A  61
THR A  64
THR A 198
ASN A 388
ADN  A 502 (-2.9A)
ADN  A 502 (-4.4A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.1A)
0.30A 4pgfB-5v96A:
56.3
4pgfB-5v96A:
56.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeo CYSTEINE SYNTHASE

(Fusobacterium
nucleatum)
no annotation 4 THR A 270
THR A 267
THR A 156
HIS A 152
None
1.38A 4pgfB-5xeoA:
2.6
4pgfB-5xeoA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4


(Pseudoxanthomonas
mexicana)
no annotation 4 THR A 450
THR A 451
THR A 425
HIS A 410
None
1.42A 4pgfB-5yp3A:
undetectable
4pgfB-5yp3A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apg DISD PROTEIN

(Sorangium
cellulosum)
no annotation 4 THR A  57
THR A  54
HIS A  85
ASN A  65
None
None
MLI  A 301 (-4.7A)
None
1.28A 4pgfB-6apgA:
undetectable
4pgfB-6apgA:
11.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE


(Elizabethkingia
anophelis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A  60
THR A  63
THR A 162
HIS A 306
ASN A 351
ADN  A 501 (-2.8A)
ADN  A 501 (-4.5A)
NAD  A 500 ( 2.9A)
ADN  A 501 ( 3.7A)
NAD  A 500 (-3.1A)
0.28A 4pgfB-6aphA:
62.5
4pgfB-6aphA:
66.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE


(Elizabethkingia
anophelis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 THR A 162
THR A 163
THR A 279
ASN A 351
NAD  A 500 ( 2.9A)
NAD  A 500 (-3.1A)
None
NAD  A 500 (-3.1A)
1.40A 4pgfB-6aphA:
62.5
4pgfB-6aphA:
66.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE


(Elizabethkingia
anophelis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 THR A 164
THR A 163
THR A 233
ASN A 303
NAD  A 500 (-3.7A)
NAD  A 500 (-3.1A)
None
None
1.42A 4pgfB-6aphA:
62.5
4pgfB-6aphA:
66.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b8d ELONGATION FACTOR G

(Haemophilus
influenzae)
no annotation 4 THR A   5
THR A   4
HIS A 365
ASN A  85
None
1.18A 4pgfB-6b8dA:
2.3
4pgfB-6b8dA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-)
no annotation 5 THR B  63
THR B  66
THR B 165
HIS B 323
ASN B 375
ADN  B 502 (-2.8A)
ADN  B 502 (-4.6A)
NAD  B 501 ( 2.8A)
ZN  B 505 (-3.2A)
NAD  B 501 (-3.0A)
0.31A 4pgfB-6f3mB:
56.2
4pgfB-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-)
no annotation 4 THR B 165
THR B 166
THR B 296
ASN B 375
NAD  B 501 ( 2.8A)
NAD  B 501 (-3.1A)
None
NAD  B 501 (-3.0A)
1.38A 4pgfB-6f3mB:
56.2
4pgfB-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-)
no annotation 5 THR A  58
THR A  61
THR A 160
HIS A 304
ASN A 349
ADN  A 501 (-2.8A)
ADN  A 501 (-4.6A)
NAD  A 502 ( 2.8A)
ADN  A 501 ( 3.6A)
NAD  A 502 (-3.1A)
0.28A 4pgfB-6gbnA:
62.6
4pgfB-6gbnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-)
no annotation 4 THR A 160
THR A 161
THR A 277
ASN A 349
NAD  A 502 ( 2.8A)
NAD  A 502 (-3.1A)
None
NAD  A 502 (-3.1A)
1.39A 4pgfB-6gbnA:
62.6
4pgfB-6gbnA:
undetectable