SIMILAR PATTERNS OF AMINO ACIDS FOR 4PGF_A_ADNA502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT
[NIFE] HYDROGENASE
SMALL SUBUNIT


(Desulfovibrio
desulfuricans)
PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
4 GLU A  22
THR A  18
THR B 492
LEU B 121
None
None
FNE  B 543 (-3.8A)
None
0.98A 4pgfA-1e3dA:
4.7
4pgfA-1e3dA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE


(Escherichia
coli)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
4 THR A 157
GLU A 182
THR A 158
HIS A 214
UAG  A1498 (-3.9A)
None
UAG  A1498 (-4.3A)
None
0.98A 4pgfA-1e8cA:
2.4
4pgfA-1e8cA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
4 THR B 303
GLU B 347
THR B 300
THR B 251
None
1.08A 4pgfA-1e9yB:
undetectable
4pgfA-1e9yB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE


(Oryza sativa)
PF00834
(Ribul_P_3_epim)
4 THR A 123
GLU A 127
THR A  91
HIS A  69
None
1.14A 4pgfA-1h1yA:
undetectable
4pgfA-1h1yA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1


(Saccharomyces
cerevisiae)
PF00398
(RrnaAD)
4 THR A 200
THR A 202
THR A 176
LEU A 151
None
0.98A 4pgfA-1i4wA:
3.0
4pgfA-1i4wA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsc ACETOHYDROXY-ACID
SYNTHASE


(Saccharomyces
cerevisiae)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 THR A 518
THR A 495
HIS A 355
LEU A 335
None
None
FAD  A 701 (-3.9A)
FAD  A 701 (-4.1A)
0.97A 4pgfA-1jscA:
3.6
4pgfA-1jscA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kph CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 1


(Mycobacterium
tuberculosis)
PF02353
(CMAS)
4 THR A 168
GLU A 140
THR A 170
LEU A 166
None
CO3  A1902 ( 3.6A)
None
None
1.10A 4pgfA-1kphA:
4.3
4pgfA-1kphA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpi CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 2


(Mycobacterium
tuberculosis)
PF02353
(CMAS)
4 THR A 183
GLU A 148
THR A 185
LEU A 181
None
CO3  A 902 ( 3.4A)
None
None
1.16A 4pgfA-1kpiA:
4.2
4pgfA-1kpiA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE


(Bos taurus)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
4 GLU A1065
THR A1066
THR A1044
HIS A 579
None
1.06A 4pgfA-1n5xA:
undetectable
4pgfA-1n5xA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA


(Geobacillus
stearothermophilus)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
4 THR A 481
GLU A 523
THR A 519
THR A 624
None
1.04A 4pgfA-1qhgA:
undetectable
4pgfA-1qhgA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))


(Geobacillus
stearothermophilus)
PF13361
(UvrD_C)
no annotation
4 THR C 481
GLU C 523
THR C 519
THR D 624
None
1.04A 4pgfA-1qhhC:
undetectable
4pgfA-1qhhC:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqb TRANSCARBOXYLASE 5S
SUBUNIT


(Propionibacterium
freudenreichii)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
4 THR A 254
GLU A  18
THR A 240
LEU A 270
None
0.84A 4pgfA-1rqbA:
undetectable
4pgfA-1rqbA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tpy METHOXY MYCOLIC ACID
SYNTHASE 2


(Mycobacterium
tuberculosis)
PF02353
(CMAS)
4 THR A 168
GLU A 140
THR A 170
LEU A 166
None
CO3  A 902 ( 3.3A)
None
None
1.13A 4pgfA-1tpyA:
4.4
4pgfA-1tpyA:
19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v8b ADENOSYLHOMOCYSTEINA
SE


(Plasmodium
falciparum)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 THR A  56
GLU A  58
THR A 201
LEU A 392
ADN  A 502 (-3.0A)
ADN  A 502 (-3.6A)
NAD  A 501 ( 2.8A)
ADN  A 502 ( 4.9A)
0.24A 4pgfA-1v8bA:
56.7
4pgfA-1v8bA:
51.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN


(Saccharomyces
cerevisiae)
PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd)
4 THR A 640
GLU A 641
THR A 508
LEU A 616
None
1.11A 4pgfA-1z45A:
9.4
4pgfA-1z45A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1za0 POSSIBLE
ACYL-[ACYL-CARRIER
PROTEIN] DESATURASE
DESA2 (ACYL-[ACP]
DESATURASE)
(STEAROYL-ACP
DESATURASE)


(Mycobacterium
tuberculosis)
PF03405
(FA_desaturase_2)
4 THR A 207
GLU A 210
THR A 211
LEU A  10
None
1.08A 4pgfA-1za0A:
undetectable
4pgfA-1za0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c55 PROTEIN P6

(Human
immunodeficiency
virus 1)
PF08705
(Gag_p6)
4 THR A  23
GLU A  19
THR A  21
LEU A  35
None
0.96A 4pgfA-2c55A:
undetectable
4pgfA-2c55A:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE


(Thermus
thermophilus)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
4 THR A 204
GLU A 206
THR A 207
THR A 176
None
1.02A 4pgfA-2cukA:
12.2
4pgfA-2cukA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida)
PF11647
(MLD)
4 THR A 710
GLU A 701
THR A 697
LEU A 676
None
1.08A 4pgfA-2ec5A:
undetectable
4pgfA-2ec5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus)
PF00491
(Arginase)
4 THR A 126
GLU A 128
THR A 129
LEU A 146
None
0.82A 4pgfA-2ef4A:
2.7
4pgfA-2ef4A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B


(Staphylococcus
aureus)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
4 THR B 255
GLU B 227
THR B 207
LEU B 257
None
1.03A 4pgfA-2f2aB:
undetectable
4pgfA-2f2aB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijc HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa)
PF02627
(CMD)
4 GLU A  93
THR A  92
THR A  82
LEU A  72
None
1.01A 4pgfA-2ijcA:
undetectable
4pgfA-2ijcA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4d HYPOTHETICAL PROTEIN
PA0269


(Pseudomonas
aeruginosa)
PF02627
(CMD)
4 GLU A  93
THR A  92
THR A  82
LEU A  72
None
1.07A 4pgfA-2o4dA:
undetectable
4pgfA-2o4dA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oap TYPE II SECRETION
SYSTEM PROTEIN


(Archaeoglobus
fulgidus)
PF00437
(T2SSE)
4 GLU 1  60
THR 1  41
HIS 1 160
LEU 1 138
None
1.11A 4pgfA-2oap1:
undetectable
4pgfA-2oap1:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7h HYPOTHETICAL PROTEIN

(Pectobacterium
atrosepticum)
PF13489
(Methyltransf_23)
4 THR A 109
THR A  37
HIS A  62
LEU A  45
TRS  A 251 (-4.1A)
None
None
None
1.04A 4pgfA-2p7hA:
4.2
4pgfA-2p7hA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vm6 BCL-2-RELATED
PROTEIN A1


(Homo sapiens)
PF00452
(Bcl-2)
4 THR A  33
GLU A 141
THR A 130
LEU A  12
None
0.89A 4pgfA-2vm6A:
undetectable
4pgfA-2vm6A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa)
PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc)
4 THR A1890
THR A1915
THR A1957
LEU A2002
None
NAP  A3002 (-4.3A)
None
None
1.14A 4pgfA-2vz9A:
undetectable
4pgfA-2vz9A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE


(Mycobacterium
tuberculosis)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
4 THR A 195
GLU A 220
THR A 196
HIS A 252
UAG  A1498 (-3.1A)
None
UAG  A1498 (-4.7A)
None
1.01A 4pgfA-2wtzA:
3.1
4pgfA-2wtzA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjn DTDP-4-KETO-6-DEOXY-
HEXOSE 3,4-ISOMERASE


(Saccharopolyspora
erythraea)
PF00067
(p450)
4 THR B  78
GLU B  79
THR B  80
THR B 102
None
1.12A 4pgfA-2yjnB:
undetectable
4pgfA-2yjnB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens)
PF00514
(Arm)
4 THR A 298
THR A 339
THR A 330
LEU A 286
None
1.09A 4pgfA-2z6hA:
undetectable
4pgfA-2z6hA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT


(Hydrogenovibrio
marinus)
PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
4 GLU B  28
THR B  24
THR A 546
LEU A 126
None
None
CYN  A 605 (-3.7A)
None
1.00A 4pgfA-3ayxB:
3.4
4pgfA-3ayxB:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE


(Mycobacterium
tuberculosis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A  71
THR A  74
THR A 219
HIS A 363
LEU A 410
ADN  A 500 (-2.8A)
ADN  A 500 (-4.5A)
NAD  A 550 ( 2.8A)
ADN  A 500 ( 3.7A)
ADN  A 500 ( 4.8A)
0.23A 4pgfA-3ce6A:
57.4
4pgfA-3ce6A:
54.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbo UNCHARACTERIZED
PROTEIN


(Mycobacterium
tuberculosis)
PF01850
(PIN)
PF02604
(PhdYeFM_antitox)
4 THR B  27
GLU B  57
THR B  54
LEU A  74
None
None
NA  B 301 (-3.5A)
None
1.02A 4pgfA-3dboB:
undetectable
4pgfA-3dboB:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1r FIBROBLAST GROWTH
FACTOR 20


(Homo sapiens)
PF00167
(FGF)
4 THR A 150
GLU A 144
THR A 188
HIS A 158
None
1.12A 4pgfA-3f1rA:
undetectable
4pgfA-3f1rA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkj PUTATIVE
PHOSPHOSUGAR
ISOMERASES


(Salmonella
enterica)
PF01380
(SIS)
4 THR A  83
GLU A  85
THR A  86
THR A  34
None
0.69A 4pgfA-3fkjA:
undetectable
4pgfA-3fkjA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN


(Bos taurus)
PF03055
(RPE65)
4 THR A 147
THR A 149
THR A 105
LEU A 133
None
1.03A 4pgfA-3fsnA:
undetectable
4pgfA-3fsnA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fve DIAMINOPIMELATE
EPIMERASE


(Mycobacterium
tuberculosis)
PF01678
(DAP_epimerase)
4 THR A 262
THR A 265
THR A 121
HIS A 123
None
None
None
GOL  A 292 (-4.2A)
1.15A 4pgfA-3fveA:
undetectable
4pgfA-3fveA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE


(Leishmania
major)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A  54
THR A  57
THR A 156
HIS A 300
LEU A 346
ADN  A 438 (-2.8A)
ADN  A 438 (-4.6A)
NAD  A 439 ( 3.0A)
ADN  A 438 ( 4.0A)
ADN  A 438 ( 4.8A)
0.20A 4pgfA-3g1uA:
62.1
4pgfA-3g1uA:
70.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4f (+)-DELTA-CADINENE
SYNTHASE ISOZYME XC1


(Gossypium
arboreum)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
4 THR A 426
GLU A 428
THR A 429
THR A 506
None
0.86A 4pgfA-3g4fA:
undetectable
4pgfA-3g4fA:
23.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE


(Burkholderia
pseudomallei)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A  64
THR A  67
THR A 200
HIS A 344
LEU A 388
RAB  A 602 (-2.7A)
RAB  A 602 (-4.5A)
NAD  A 601 ( 2.9A)
RAB  A 602 ( 3.5A)
RAB  A 602 ( 4.7A)
0.25A 4pgfA-3glqA:
58.9
4pgfA-3glqA:
56.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gw7 UNCHARACTERIZED
PROTEIN YEDJ


(Escherichia
coli)
PF01966
(HD)
4 THR A 184
THR A 176
HIS A 173
LEU A 132
None
1.15A 4pgfA-3gw7A:
undetectable
4pgfA-3gw7A:
19.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h9u ADENOSYLHOMOCYSTEINA
SE


(Trypanosoma
brucei)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A  54
THR A  57
THR A 156
HIS A 300
LEU A 346
ADN  A 439 (-2.7A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
ADN  A 439 ( 4.7A)
0.35A 4pgfA-3h9uA:
63.7
4pgfA-3h9uA:
71.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT


(Saccharomyces
cerevisiae)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
4 THR A 248
GLU A 232
THR A 246
LEU A 160
None
0.86A 4pgfA-3iayA:
undetectable
4pgfA-3iayA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqy PUTATIVE
ISOCHORISMATASE
HYDROLASE


(Oleispira
antarctica)
PF00857
(Isochorismatase)
4 THR A 130
THR A 149
HIS A 165
LEU A 172
None
GOL  A 190 (-4.6A)
GOL  A 190 (-3.8A)
None
1.12A 4pgfA-3lqyA:
3.0
4pgfA-3lqyA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lun ULILYSIN

(Methanosarcina
acetivorans)
PF05572
(Peptidase_M43)
4 GLU A 229
THR A 225
HIS A 177
LEU A 179
ZN  A 999 ( 3.8A)
None
None
None
1.15A 4pgfA-3lunA:
undetectable
4pgfA-3lunA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3md0 ARGININE/ORNITHINE
TRANSPORT SYSTEM
ATPASE


(Mycobacterium
tuberculosis)
PF03308
(ArgK)
4 GLU A 157
THR A 158
THR A 174
LEU A 178
None
1.14A 4pgfA-3md0A:
4.0
4pgfA-3md0A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwb PREPHENATE
DEHYDRATASE


(Paenarthrobacter
aurescens)
PF00800
(PDT)
PF01842
(ACT)
4 THR A  14
GLU A  61
THR A  16
THR A  39
None
0.98A 4pgfA-3mwbA:
undetectable
4pgfA-3mwbA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1


(Saccharomyces
cerevisiae)
PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF00385
(Chromo)
4 GLU W 840
THR W 904
HIS W 806
LEU W 799
None
1.12A 4pgfA-3mwyW:
undetectable
4pgfA-3mwyW:
20.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n58 ADENOSYLHOMOCYSTEINA
SE


(Brucella
abortus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A  57
THR A  60
THR A 193
HIS A 337
LEU A 381
ADN  A 500 (-2.8A)
ADN  A 500 (-4.6A)
NAD  A 550 ( 3.0A)
ADN  A 500 ( 3.6A)
ADN  A 500 ( 4.8A)
0.21A 4pgfA-3n58A:
58.8
4pgfA-3n58A:
58.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nok GLUTAMINYL CYCLASE

(Myxococcus
xanthus)
PF05096
(Glu_cyclase_2)
4 GLU A 231
THR A 240
HIS A  39
LEU A  70
None
0.90A 4pgfA-3nokA:
undetectable
4pgfA-3nokA:
22.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE


(Lupinus luteus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A  64
THR A  67
THR A 206
HIS A 350
LEU A 398
ADE  A 506 (-2.8A)
ADE  A 506 (-4.5A)
NAD  A 501 (-2.8A)
None
ADE  A 506 ( 4.7A)
0.22A 4pgfA-3oneA:
55.5
4pgfA-3oneA:
55.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot5 UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE


(Listeria
monocytogenes)
PF02350
(Epimerase_2)
4 GLU A 310
THR A 176
HIS A  97
LEU A 124
None
1.00A 4pgfA-3ot5A:
3.2
4pgfA-3ot5A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus)
PF00067
(p450)
4 GLU A 364
THR A 110
HIS A 107
LEU A 155
HEM  A 501 (-4.3A)
None
None
None
1.00A 4pgfA-3p3lA:
undetectable
4pgfA-3p3lA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe7 URACIL PERMEASE

(Escherichia
coli)
PF00860
(Xan_ur_permease)
4 THR A 303
THR A 287
HIS A 242
LEU A 257
None
1.06A 4pgfA-3qe7A:
undetectable
4pgfA-3qe7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfi TRANSCRIPTIONAL
REGULATOR


(Enterococcus
faecalis)
PF03816
(LytR_cpsA_psr)
4 THR A 295
GLU A 270
THR A  85
LEU A 272
None
1.16A 4pgfA-3qfiA:
undetectable
4pgfA-3qfiA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qoy 50S RIBOSOMAL
PROTEIN L1


(Aquifex
aeolicus)
PF00687
(Ribosomal_L1)
4 THR A 221
GLU A  43
THR A  44
THR A 113
None
0.95A 4pgfA-3qoyA:
undetectable
4pgfA-3qoyA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnd ANTITOXIN VAPB

(Shigella
flexneri)
PF04014
(MazE_antitoxin)
4 THR B  46
GLU B  30
THR B  41
THR B  37
None
1.07A 4pgfA-3tndB:
undetectable
4pgfA-3tndB:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usc HYDROGENASE-1 LARGE
CHAIN


(Escherichia
coli)
PF00374
(NiFeSe_Hases)
4 THR L 505
THR L 113
HIS L 220
LEU L  85
None
1.10A 4pgfA-3uscL:
undetectable
4pgfA-3uscL:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 THR A 383
THR A 382
HIS A 433
LEU A  97
None
1.07A 4pgfA-3v9eA:
undetectable
4pgfA-3v9eA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE


(Staphylococcus
aureus)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
4 THR A 152
GLU A 177
THR A 153
HIS A 209
UML  A 598 (-4.0A)
MG  A 503 (-2.8A)
UML  A 598 (-4.6A)
None
1.07A 4pgfA-4c13A:
undetectable
4pgfA-4c13A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT
HYDROGENASE-1 SMALL
SUBUNIT


(Salmonella
enterica)
PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
4 GLU B  22
THR B  18
THR A 535
LEU A 126
None
None
NFU  A1004 (-3.7A)
None
0.96A 4pgfA-4c3oB:
3.3
4pgfA-4c3oB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el8 GLYCOSIDE HYDROLASE
FAMILY 48


(Caldicellulosiruptor
bescii)
PF02011
(Glyco_hydro_48)
4 THR A 176
THR A 188
HIS A  36
LEU A 152
None
1.04A 4pgfA-4el8A:
undetectable
4pgfA-4el8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN


(Idiomarina
loihiensis)
PF05299
(Peptidase_M61)
PF13180
(PDZ_2)
4 THR A 419
THR A 310
HIS A 277
LEU A 284
None
ZN  A 602 ( 4.8A)
ZN  A 602 ( 3.2A)
None
0.98A 4pgfA-4fgmA:
undetectable
4pgfA-4fgmA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN


(Hahella
chejuensis)
PF02011
(Glyco_hydro_48)
4 THR A 205
THR A 217
HIS A  64
LEU A 181
None
None
CBI  A 802 (-4.4A)
None
1.04A 4pgfA-4fusA:
undetectable
4pgfA-4fusA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq1 NUP37

(Schizosaccharomyces
pombe)
PF00400
(WD40)
4 GLU A  61
THR A  64
THR A  20
LEU A  11
None
1.13A 4pgfA-4gq1A:
undetectable
4pgfA-4gq1A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix9 V-TYPE PROTON ATPASE
SUBUNIT F


(Saccharomyces
cerevisiae)
PF01990
(ATP-synt_F)
4 THR A  29
GLU A  31
THR A  32
LEU A   7
None
None
None
TRS  A 101 (-3.6A)
0.95A 4pgfA-4ix9A:
undetectable
4pgfA-4ix9A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjj CELLULOSE
1,4-BETA-CELLOBIOSID
ASE


(Thermobifida
fusca)
PF02011
(Glyco_hydro_48)
4 THR A 174
THR A 186
HIS A  32
LEU A 149
None
None
CBI  A 701 ( 4.4A)
None
1.04A 4pgfA-4jjjA:
undetectable
4pgfA-4jjjA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjj CELLULOSE
1,4-BETA-CELLOBIOSID
ASE


(Thermobifida
fusca)
PF02011
(Glyco_hydro_48)
4 THR A 452
THR A 543
HIS A 535
LEU A 528
None
None
ZN  A 722 ( 3.2A)
None
0.97A 4pgfA-4jjjA:
undetectable
4pgfA-4jjjA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4i RYANODINE RECEPTOR 2

(Mus musculus)
PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec)
4 THR A 302
THR A 301
HIS A 261
LEU A 316
None
1.07A 4pgfA-4l4iA:
undetectable
4pgfA-4l4iA:
20.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)


(Bradyrhizobium
elkanii)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A  60
THR A  63
THR A 198
HIS A 342
LEU A 386
ADN  A 501 (-2.8A)
ADN  A 501 (-4.5A)
NAD  A 503 ( 2.9A)
ADN  A 501 ( 3.7A)
ADN  A 501 ( 4.7A)
0.23A 4pgfA-4lvcA:
59.5
4pgfA-4lvcA:
57.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E


(Butyrivibrio
proteoclasticus)
PF04616
(Glyco_hydro_43)
4 THR A  38
THR A  22
HIS A  12
LEU A  36
None
1.13A 4pgfA-4novA:
undetectable
4pgfA-4novA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B


(Danio rerio)
PF06662
(C5-epim_C)
4 THR A 343
GLU A 282
THR A 281
LEU A 326
None
0.99A 4pgfA-4pxqA:
undetectable
4pgfA-4pxqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q05 ESTERASE E25

(uncultured
bacterium)
PF07859
(Abhydrolase_3)
4 GLU A 323
THR A 324
THR A 214
HIS A 312
None
0.96A 4pgfA-4q05A:
5.7
4pgfA-4q05A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE


(Geobacillus
stearothermophilus)
PF07944
(Glyco_hydro_127)
4 THR A 442
THR A   8
HIS A 433
LEU A 430
None
0.90A 4pgfA-4qjyA:
undetectable
4pgfA-4qjyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7f UNCHARACTERIZED
PROTEIN


(Parabacteroides
merdae)
PF17116
(DUF5103)
4 THR A 115
THR A 114
HIS A 315
LEU A 359
None
1.04A 4pgfA-4r7fA:
undetectable
4pgfA-4r7fA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
4 THR A 224
THR A 283
HIS A 147
LEU A 171
None
0.96A 4pgfA-4usfA:
undetectable
4pgfA-4usfA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwl EXOGLUCANASE S

(Clostridium
cellulovorans)
PF02011
(Glyco_hydro_48)
4 THR A 172
THR A 184
HIS A  31
LEU A 150
None
1.13A 4pgfA-4xwlA:
undetectable
4pgfA-4xwlA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME


(Drosophila
melanogaster)
PF01401
(Peptidase_M2)
4 THR A  40
GLU A  43
THR A  44
HIS A 394
None
0.99A 4pgfA-5a2rA:
undetectable
4pgfA-5a2rA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED


(Bacteroides
thetaiotaomicron)
PF04041
(Glyco_hydro_130)
4 THR B 148
GLU B 150
HIS B 181
LEU B 238
None
1.14A 4pgfA-5a7vB:
undetectable
4pgfA-5a7vB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5all SOLUBLE EPOXIDE
HYDROLASE


(Homo sapiens)
PF00561
(Abhydrolase_1)
PF13419
(HAD_2)
4 THR A 125
GLU A 152
THR A 123
LEU A 136
None
1.01A 4pgfA-5allA:
5.4
4pgfA-5allA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN


(Colletotrichum
graminicola)
PF01344
(Kelch_1)
PF09118
(DUF1929)
4 THR A  49
THR A  47
THR A  76
LEU A  29
None
1.05A 4pgfA-5c92A:
undetectable
4pgfA-5c92A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9


(Staphylococcus
aureus)
PF13395
(HNH_4)
PF16592
(Cas9_REC)
4 THR A 512
THR A 511
HIS A 527
LEU A 547
None
0.87A 4pgfA-5czzA:
undetectable
4pgfA-5czzA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
4 THR A 222
THR A 280
HIS A 145
LEU A 169
THR  A 222 ( 0.8A)
THR  A 280 ( 0.8A)
HIS  A 145 ( 1.0A)
LEU  A 169 ( 0.6A)
0.84A 4pgfA-5d7aA:
undetectable
4pgfA-5d7aA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE


(Burkholderia
vietnamiensis)
PF02350
(Epimerase_2)
4 GLU A 316
THR A 173
HIS A  94
LEU A 121
None
1.00A 4pgfA-5dldA:
6.1
4pgfA-5dldA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doz JAMJ

(Lyngbya
majuscula)
PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2)
4 GLU A 213
THR A 215
THR A 182
HIS A 158
None
1.11A 4pgfA-5dozA:
9.7
4pgfA-5dozA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e25 BRANCHED-CHAIN
AMINOTRANSFERASE


(Geoglobus
acetivorans)
PF01063
(Aminotran_4)
4 GLU A 286
THR A 283
THR A 246
LEU A 219
None
1.13A 4pgfA-5e25A:
undetectable
4pgfA-5e25A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhx INTERLEUKIN-4

(Homo sapiens)
PF00727
(IL4)
4 THR A  39
GLU A  43
THR A  44
THR A  30
None
1.14A 4pgfA-5fhxA:
undetectable
4pgfA-5fhxA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k13 RETINOIC ACID
RECEPTOR ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
4 THR A 397
THR A 306
HIS A 298
LEU A 220
None
0.93A 4pgfA-5k13A:
undetectable
4pgfA-5k13A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE


(metagenome)
no annotation 4 THR A  97
GLU A 121
THR A 268
LEU A 295
None
1.15A 4pgfA-5nfqA:
4.7
4pgfA-5nfqA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE


(Ruminiclostridium
thermocellum)
PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36)
4 THR A 281
THR A 283
THR A 364
HIS A 367
None
1.08A 4pgfA-5nz7A:
undetectable
4pgfA-5nz7A:
18.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5utu ADENOSYLHOMOCYSTEINA
SE


(Cryptosporidium
parvum)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A  55
GLU A  57
THR A  58
THR A 212
LEU A 404
SAH  A 502 (-2.7A)
SAH  A 502 (-3.7A)
SAH  A 502 (-4.2A)
NAD  A 501 ( 4.1A)
SAH  A 502 ( 4.7A)
0.40A 4pgfA-5utuA:
53.5
4pgfA-5utuA:
47.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE


(Naegleria
fowleri)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A  61
GLU A  63
THR A  64
THR A 198
LEU A 389
ADN  A 502 (-2.9A)
ADN  A 502 (-3.6A)
ADN  A 502 (-4.4A)
NAD  A 501 ( 2.9A)
ADN  A 502 ( 4.7A)
0.18A 4pgfA-5v96A:
58.8
4pgfA-5v96A:
56.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w4b ADENOSYLHOMOCYSTEINA
SE


(Homo sapiens)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 THR A  57
GLU A  59
THR A  60
THR A 157
9W4  A 502 (-2.9A)
9W4  A 502 (-3.8A)
None
None
0.62A 4pgfA-5w4bA:
55.9
4pgfA-5w4bA:
99.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN


(Ruminiclostridium
thermocellum)
no annotation 4 THR A 205
THR A 217
HIS A  68
LEU A 185
None
1.06A 4pgfA-5yj6A:
undetectable
4pgfA-5yj6A:
12.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE


(Elizabethkingia
anophelis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A  60
THR A  63
THR A 162
HIS A 306
LEU A 352
ADN  A 501 (-2.8A)
ADN  A 501 (-4.5A)
NAD  A 500 ( 2.9A)
ADN  A 501 ( 3.7A)
ADN  A 501 ( 4.8A)
0.18A 4pgfA-6aphA:
64.0
4pgfA-6aphA:
66.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brd RIFAMPIN
MONOOXYGENASE


(Streptomyces
venezuelae)
no annotation 4 GLU A 173
THR A 174
THR A 335
HIS A 282
None
1.10A 4pgfA-6brdA:
undetectable
4pgfA-6brdA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE


(Marinobacter
hydrocarbonoclasticus)
no annotation 4 GLU A 422
THR A 415
THR A 132
LEU A 395
None
1.10A 4pgfA-6chjA:
undetectable
4pgfA-6chjA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eux POLYMERASE BASIC
PROTEIN 2


(Influenza B
virus)
no annotation 4 THR A 482
GLU A 461
HIS A 366
LEU A 387
None
1.11A 4pgfA-6euxA:
undetectable
4pgfA-6euxA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-)
no annotation 5 THR B  63
THR B  66
THR B 165
HIS B 323
LEU B 376
ADN  B 502 (-2.8A)
ADN  B 502 (-4.6A)
NAD  B 501 ( 2.8A)
ZN  B 505 (-3.2A)
ADN  B 502 ( 4.8A)
0.26A 4pgfA-6f3mB:
57.1
4pgfA-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-)
no annotation 5 THR A  58
THR A  61
THR A 160
HIS A 304
LEU A 350
ADN  A 501 (-2.8A)
ADN  A 501 (-4.6A)
NAD  A 502 ( 2.8A)
ADN  A 501 ( 3.6A)
ADN  A 501 ( 4.7A)
0.21A 4pgfA-6gbnA:
64.1
4pgfA-6gbnA:
undetectable