SIMILAR PATTERNS OF AMINO ACIDS FOR 4PGF_A_ADNA502_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e3d | [NIFE] HYDROGENASELARGE SUBUNIT[NIFE] HYDROGENASESMALL SUBUNIT (Desulfovibriodesulfuricans) |
PF00374(NiFeSe_Hases)PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 4 | GLU A 22THR A 18THR B 492LEU B 121 | NoneNoneFNE B 543 (-3.8A)None | 0.98A | 4pgfA-1e3dA:4.7 | 4pgfA-1e3dA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e8c | UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATELIGASE (Escherichiacoli) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 4 | THR A 157GLU A 182THR A 158HIS A 214 | UAG A1498 (-3.9A)NoneUAG A1498 (-4.3A)None | 0.98A | 4pgfA-1e8cA:2.4 | 4pgfA-1e8cA:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e9y | UREASE SUBUNIT BETA (Helicobacterpylori) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 4 | THR B 303GLU B 347THR B 300THR B 251 | None | 1.08A | 4pgfA-1e9yB:undetectable | 4pgfA-1e9yB:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h1y | D-RIBULOSE-5-PHOSPHATE 3-EPIMERASE (Oryza sativa) |
PF00834(Ribul_P_3_epim) | 4 | THR A 123GLU A 127THR A 91HIS A 69 | None | 1.14A | 4pgfA-1h1yA:undetectable | 4pgfA-1h1yA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i4w | MITOCHONDRIALREPLICATION PROTEINMTF1 (Saccharomycescerevisiae) |
PF00398(RrnaAD) | 4 | THR A 200THR A 202THR A 176LEU A 151 | None | 0.98A | 4pgfA-1i4wA:3.0 | 4pgfA-1i4wA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jsc | ACETOHYDROXY-ACIDSYNTHASE (Saccharomycescerevisiae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 4 | THR A 518THR A 495HIS A 355LEU A 335 | NoneNoneFAD A 701 (-3.9A)FAD A 701 (-4.1A) | 0.97A | 4pgfA-1jscA:3.6 | 4pgfA-1jscA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kph | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPIDSYNTHASE 1 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 4 | THR A 168GLU A 140THR A 170LEU A 166 | NoneCO3 A1902 ( 3.6A)NoneNone | 1.10A | 4pgfA-1kphA:4.3 | 4pgfA-1kphA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kpi | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPIDSYNTHASE 2 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 4 | THR A 183GLU A 148THR A 185LEU A 181 | NoneCO3 A 902 ( 3.4A)NoneNone | 1.16A | 4pgfA-1kpiA:4.2 | 4pgfA-1kpiA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n5x | XANTHINEDEHYDROGENASE (Bos taurus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 4 | GLU A1065THR A1066THR A1044HIS A 579 | None | 1.06A | 4pgfA-1n5xA:undetectable | 4pgfA-1n5xA:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhg | ATP-DEPENDENTHELICASE PCRA (Geobacillusstearothermophilus) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 4 | THR A 481GLU A 523THR A 519THR A 624 | None | 1.04A | 4pgfA-1qhgA:undetectable | 4pgfA-1qhgA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhh | PROTEIN (PCRA(SUBUNIT)) (Geobacillusstearothermophilus) |
PF13361(UvrD_C)no annotation | 4 | THR C 481GLU C 523THR C 519THR D 624 | None | 1.04A | 4pgfA-1qhhC:undetectable | 4pgfA-1qhhC:15.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rqb | TRANSCARBOXYLASE 5SSUBUNIT (Propionibacteriumfreudenreichii) |
PF00682(HMGL-like)PF02436(PYC_OADA) | 4 | THR A 254GLU A 18THR A 240LEU A 270 | None | 0.84A | 4pgfA-1rqbA:undetectable | 4pgfA-1rqbA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tpy | METHOXY MYCOLIC ACIDSYNTHASE 2 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 4 | THR A 168GLU A 140THR A 170LEU A 166 | NoneCO3 A 902 ( 3.3A)NoneNone | 1.13A | 4pgfA-1tpyA:4.4 | 4pgfA-1tpyA:19.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1v8b | ADENOSYLHOMOCYSTEINASE (Plasmodiumfalciparum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 56GLU A 58THR A 201LEU A 392 | ADN A 502 (-3.0A)ADN A 502 (-3.6A)NAD A 501 ( 2.8A)ADN A 502 ( 4.9A) | 0.24A | 4pgfA-1v8bA:56.7 | 4pgfA-1v8bA:51.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z45 | GAL10 BIFUNCTIONALPROTEIN (Saccharomycescerevisiae) |
PF01263(Aldose_epim)PF16363(GDP_Man_Dehyd) | 4 | THR A 640GLU A 641THR A 508LEU A 616 | None | 1.11A | 4pgfA-1z45A:9.4 | 4pgfA-1z45A:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1za0 | POSSIBLEACYL-[ACYL-CARRIERPROTEIN] DESATURASEDESA2 (ACYL-[ACP]DESATURASE)(STEAROYL-ACPDESATURASE) (Mycobacteriumtuberculosis) |
PF03405(FA_desaturase_2) | 4 | THR A 207GLU A 210THR A 211LEU A 10 | None | 1.08A | 4pgfA-1za0A:undetectable | 4pgfA-1za0A:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c55 | PROTEIN P6 (Humanimmunodeficiencyvirus 1) |
PF08705(Gag_p6) | 4 | THR A 23GLU A 19THR A 21LEU A 35 | None | 0.96A | 4pgfA-2c55A:undetectable | 4pgfA-2c55A:7.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cuk | GLYCERATEDEHYDROGENASE/GLYOXYLATE REDUCTASE (Thermusthermophilus) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 4 | THR A 204GLU A 206THR A 207THR A 176 | None | 1.02A | 4pgfA-2cukA:12.2 | 4pgfA-2cukA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ec5 | DERMONECROTIC TOXIN (Pasteurellamultocida) |
PF11647(MLD) | 4 | THR A 710GLU A 701THR A 697LEU A 676 | None | 1.08A | 4pgfA-2ec5A:undetectable | 4pgfA-2ec5A:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ef4 | ARGINASE (Thermusthermophilus) |
PF00491(Arginase) | 4 | THR A 126GLU A 128THR A 129LEU A 146 | None | 0.82A | 4pgfA-2ef4A:2.7 | 4pgfA-2ef4A:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f2a | ASPARTYL/GLUTAMYL-TRNA(ASN/GLN)AMIDOTRANSFERASESUBUNIT B (Staphylococcusaureus) |
PF02637(GatB_Yqey)PF02934(GatB_N) | 4 | THR B 255GLU B 227THR B 207LEU B 257 | None | 1.03A | 4pgfA-2f2aB:undetectable | 4pgfA-2f2aB:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ijc | HYPOTHETICAL PROTEIN (Pseudomonasaeruginosa) |
PF02627(CMD) | 4 | GLU A 93THR A 92THR A 82LEU A 72 | None | 1.01A | 4pgfA-2ijcA:undetectable | 4pgfA-2ijcA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o4d | HYPOTHETICAL PROTEINPA0269 (Pseudomonasaeruginosa) |
PF02627(CMD) | 4 | GLU A 93THR A 92THR A 82LEU A 72 | None | 1.07A | 4pgfA-2o4dA:undetectable | 4pgfA-2o4dA:15.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oap | TYPE II SECRETIONSYSTEM PROTEIN (Archaeoglobusfulgidus) |
PF00437(T2SSE) | 4 | GLU 1 60THR 1 41HIS 1 160LEU 1 138 | None | 1.11A | 4pgfA-2oap1:undetectable | 4pgfA-2oap1:26.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p7h | HYPOTHETICAL PROTEIN (Pectobacteriumatrosepticum) |
PF13489(Methyltransf_23) | 4 | THR A 109THR A 37HIS A 62LEU A 45 | TRS A 251 (-4.1A)NoneNoneNone | 1.04A | 4pgfA-2p7hA:4.2 | 4pgfA-2p7hA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vm6 | BCL-2-RELATEDPROTEIN A1 (Homo sapiens) |
PF00452(Bcl-2) | 4 | THR A 33GLU A 141THR A 130LEU A 12 | None | 0.89A | 4pgfA-2vm6A:undetectable | 4pgfA-2vm6A:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vz9 | FATTY ACID SYNTHASE (Sus scrofa) |
PF00107(ADH_zinc_N)PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF08242(Methyltransf_12)PF08659(KR)PF14765(PS-DH)PF16197(KAsynt_C_assoc) | 4 | THR A1890THR A1915THR A1957LEU A2002 | NoneNAP A3002 (-4.3A)NoneNone | 1.14A | 4pgfA-2vz9A:undetectable | 4pgfA-2vz9A:10.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wtz | UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATE LIGASE (Mycobacteriumtuberculosis) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 4 | THR A 195GLU A 220THR A 196HIS A 252 | UAG A1498 (-3.1A)NoneUAG A1498 (-4.7A)None | 1.01A | 4pgfA-2wtzA:3.1 | 4pgfA-2wtzA:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yjn | DTDP-4-KETO-6-DEOXY-HEXOSE 3,4-ISOMERASE (Saccharopolysporaerythraea) |
PF00067(p450) | 4 | THR B 78GLU B 79THR B 80THR B 102 | None | 1.12A | 4pgfA-2yjnB:undetectable | 4pgfA-2yjnB:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z6h | CATENIN BETA-1 (Homo sapiens) |
PF00514(Arm) | 4 | THR A 298THR A 339THR A 330LEU A 286 | None | 1.09A | 4pgfA-2z6hA:undetectable | 4pgfA-2z6hA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayx | MEMBRANE-BOUNDHYDROGENASE LARGESUBUNITMEMBRANE-BOUNDHYDROGENASE SMALLSUBUNIT (Hydrogenovibriomarinus) |
PF00374(NiFeSe_Hases)PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 4 | GLU B 28THR B 24THR A 546LEU A 126 | NoneNoneCYN A 605 (-3.7A)None | 1.00A | 4pgfA-3ayxB:3.4 | 4pgfA-3ayxB:22.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 71THR A 74THR A 219HIS A 363LEU A 410 | ADN A 500 (-2.8A)ADN A 500 (-4.5A)NAD A 550 ( 2.8A)ADN A 500 ( 3.7A)ADN A 500 ( 4.8A) | 0.23A | 4pgfA-3ce6A:57.4 | 4pgfA-3ce6A:54.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dbo | UNCHARACTERIZEDPROTEIN (Mycobacteriumtuberculosis) |
PF01850(PIN)PF02604(PhdYeFM_antitox) | 4 | THR B 27GLU B 57THR B 54LEU A 74 | NoneNone NA B 301 (-3.5A)None | 1.02A | 4pgfA-3dboB:undetectable | 4pgfA-3dboB:16.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f1r | FIBROBLAST GROWTHFACTOR 20 (Homo sapiens) |
PF00167(FGF) | 4 | THR A 150GLU A 144THR A 188HIS A 158 | None | 1.12A | 4pgfA-3f1rA:undetectable | 4pgfA-3f1rA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fkj | PUTATIVEPHOSPHOSUGARISOMERASES (Salmonellaenterica) |
PF01380(SIS) | 4 | THR A 83GLU A 85THR A 86THR A 34 | None | 0.69A | 4pgfA-3fkjA:undetectable | 4pgfA-3fkjA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fsn | RETINAL PIGMENTEPITHELIUM-SPECIFIC65 KDA PROTEIN (Bos taurus) |
PF03055(RPE65) | 4 | THR A 147THR A 149THR A 105LEU A 133 | None | 1.03A | 4pgfA-3fsnA:undetectable | 4pgfA-3fsnA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fve | DIAMINOPIMELATEEPIMERASE (Mycobacteriumtuberculosis) |
PF01678(DAP_epimerase) | 4 | THR A 262THR A 265THR A 121HIS A 123 | NoneNoneNoneGOL A 292 (-4.2A) | 1.15A | 4pgfA-3fveA:undetectable | 4pgfA-3fveA:20.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 54THR A 57THR A 156HIS A 300LEU A 346 | ADN A 438 (-2.8A)ADN A 438 (-4.6A)NAD A 439 ( 3.0A)ADN A 438 ( 4.0A)ADN A 438 ( 4.8A) | 0.20A | 4pgfA-3g1uA:62.1 | 4pgfA-3g1uA:70.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g4f | (+)-DELTA-CADINENESYNTHASE ISOZYME XC1 (Gossypiumarboreum) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 4 | THR A 426GLU A 428THR A 429THR A 506 | None | 0.86A | 4pgfA-3g4fA:undetectable | 4pgfA-3g4fA:23.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 64THR A 67THR A 200HIS A 344LEU A 388 | RAB A 602 (-2.7A)RAB A 602 (-4.5A)NAD A 601 ( 2.9A)RAB A 602 ( 3.5A)RAB A 602 ( 4.7A) | 0.25A | 4pgfA-3glqA:58.9 | 4pgfA-3glqA:56.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gw7 | UNCHARACTERIZEDPROTEIN YEDJ (Escherichiacoli) |
PF01966(HD) | 4 | THR A 184THR A 176HIS A 173LEU A 132 | None | 1.15A | 4pgfA-3gw7A:undetectable | 4pgfA-3gw7A:19.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h9u | ADENOSYLHOMOCYSTEINASE (Trypanosomabrucei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 54THR A 57THR A 156HIS A 300LEU A 346 | ADN A 439 (-2.7A)ADN A 439 (-4.7A)NAD A 438 (-3.8A)NoneADN A 439 ( 4.7A) | 0.35A | 4pgfA-3h9uA:63.7 | 4pgfA-3h9uA:71.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iay | DNA POLYMERASE DELTACATALYTIC SUBUNIT (Saccharomycescerevisiae) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 4 | THR A 248GLU A 232THR A 246LEU A 160 | None | 0.86A | 4pgfA-3iayA:undetectable | 4pgfA-3iayA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lqy | PUTATIVEISOCHORISMATASEHYDROLASE (Oleispiraantarctica) |
PF00857(Isochorismatase) | 4 | THR A 130THR A 149HIS A 165LEU A 172 | NoneGOL A 190 (-4.6A)GOL A 190 (-3.8A)None | 1.12A | 4pgfA-3lqyA:3.0 | 4pgfA-3lqyA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lun | ULILYSIN (Methanosarcinaacetivorans) |
PF05572(Peptidase_M43) | 4 | GLU A 229THR A 225HIS A 177LEU A 179 | ZN A 999 ( 3.8A)NoneNoneNone | 1.15A | 4pgfA-3lunA:undetectable | 4pgfA-3lunA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3md0 | ARGININE/ORNITHINETRANSPORT SYSTEMATPASE (Mycobacteriumtuberculosis) |
PF03308(ArgK) | 4 | GLU A 157THR A 158THR A 174LEU A 178 | None | 1.14A | 4pgfA-3md0A:4.0 | 4pgfA-3md0A:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mwb | PREPHENATEDEHYDRATASE (Paenarthrobacteraurescens) |
PF00800(PDT)PF01842(ACT) | 4 | THR A 14GLU A 61THR A 16THR A 39 | None | 0.98A | 4pgfA-3mwbA:undetectable | 4pgfA-3mwbA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mwy | CHROMODOMAIN-CONTAININGPROTEIN 1 (Saccharomycescerevisiae) |
PF00176(SNF2_N)PF00271(Helicase_C)PF00385(Chromo) | 4 | GLU W 840THR W 904HIS W 806LEU W 799 | None | 1.12A | 4pgfA-3mwyW:undetectable | 4pgfA-3mwyW:20.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n58 | ADENOSYLHOMOCYSTEINASE (Brucellaabortus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 57THR A 60THR A 193HIS A 337LEU A 381 | ADN A 500 (-2.8A)ADN A 500 (-4.6A)NAD A 550 ( 3.0A)ADN A 500 ( 3.6A)ADN A 500 ( 4.8A) | 0.21A | 4pgfA-3n58A:58.8 | 4pgfA-3n58A:58.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nok | GLUTAMINYL CYCLASE (Myxococcusxanthus) |
PF05096(Glu_cyclase_2) | 4 | GLU A 231THR A 240HIS A 39LEU A 70 | None | 0.90A | 4pgfA-3nokA:undetectable | 4pgfA-3nokA:22.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 64THR A 67THR A 206HIS A 350LEU A 398 | ADE A 506 (-2.8A)ADE A 506 (-4.5A)NAD A 501 (-2.8A)NoneADE A 506 ( 4.7A) | 0.22A | 4pgfA-3oneA:55.5 | 4pgfA-3oneA:55.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ot5 | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Listeriamonocytogenes) |
PF02350(Epimerase_2) | 4 | GLU A 310THR A 176HIS A 97LEU A 124 | None | 1.00A | 4pgfA-3ot5A:3.2 | 4pgfA-3ot5A:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p3l | CYTOCHROME P450 (Streptomycesthioluteus) |
PF00067(p450) | 4 | GLU A 364THR A 110HIS A 107LEU A 155 | HEM A 501 (-4.3A)NoneNoneNone | 1.00A | 4pgfA-3p3lA:undetectable | 4pgfA-3p3lA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qe7 | URACIL PERMEASE (Escherichiacoli) |
PF00860(Xan_ur_permease) | 4 | THR A 303THR A 287HIS A 242LEU A 257 | None | 1.06A | 4pgfA-3qe7A:undetectable | 4pgfA-3qe7A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qfi | TRANSCRIPTIONALREGULATOR (Enterococcusfaecalis) |
PF03816(LytR_cpsA_psr) | 4 | THR A 295GLU A 270THR A 85LEU A 272 | None | 1.16A | 4pgfA-3qfiA:undetectable | 4pgfA-3qfiA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qoy | 50S RIBOSOMALPROTEIN L1 (Aquifexaeolicus) |
PF00687(Ribosomal_L1) | 4 | THR A 221GLU A 43THR A 44THR A 113 | None | 0.95A | 4pgfA-3qoyA:undetectable | 4pgfA-3qoyA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tnd | ANTITOXIN VAPB (Shigellaflexneri) |
PF04014(MazE_antitoxin) | 4 | THR B 46GLU B 30THR B 41THR B 37 | None | 1.07A | 4pgfA-3tndB:undetectable | 4pgfA-3tndB:11.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3usc | HYDROGENASE-1 LARGECHAIN (Escherichiacoli) |
PF00374(NiFeSe_Hases) | 4 | THR L 505THR L 113HIS L 220LEU L 85 | None | 1.10A | 4pgfA-3uscL:undetectable | 4pgfA-3uscL:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v9e | LACCASE (Botrytis aclada) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | THR A 383THR A 382HIS A 433LEU A 97 | None | 1.07A | 4pgfA-3v9eA:undetectable | 4pgfA-3v9eA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c13 | UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE--L-LYSINE LIGASE (Staphylococcusaureus) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 4 | THR A 152GLU A 177THR A 153HIS A 209 | UML A 598 (-4.0A) MG A 503 (-2.8A)UML A 598 (-4.6A)None | 1.07A | 4pgfA-4c13A:undetectable | 4pgfA-4c13A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c3o | HYDROGENASE-1 LARGESUBUNITHYDROGENASE-1 SMALLSUBUNIT (Salmonellaenterica) |
PF00374(NiFeSe_Hases)PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 4 | GLU B 22THR B 18THR A 535LEU A 126 | NoneNoneNFU A1004 (-3.7A)None | 0.96A | 4pgfA-4c3oB:3.3 | 4pgfA-4c3oB:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4el8 | GLYCOSIDE HYDROLASEFAMILY 48 (Caldicellulosiruptorbescii) |
PF02011(Glyco_hydro_48) | 4 | THR A 176THR A 188HIS A 36LEU A 152 | None | 1.04A | 4pgfA-4el8A:undetectable | 4pgfA-4el8A:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fgm | AMINOPEPTIDASE NFAMILY PROTEIN (Idiomarinaloihiensis) |
PF05299(Peptidase_M61)PF13180(PDZ_2) | 4 | THR A 419THR A 310HIS A 277LEU A 284 | None ZN A 602 ( 4.8A) ZN A 602 ( 3.2A)None | 0.98A | 4pgfA-4fgmA:undetectable | 4pgfA-4fgmA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fus | RTX TOXINS ANDRELATED CA2+-BINDINGPROTEIN (Hahellachejuensis) |
PF02011(Glyco_hydro_48) | 4 | THR A 205THR A 217HIS A 64LEU A 181 | NoneNoneCBI A 802 (-4.4A)None | 1.04A | 4pgfA-4fusA:undetectable | 4pgfA-4fusA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gq1 | NUP37 (Schizosaccharomycespombe) |
PF00400(WD40) | 4 | GLU A 61THR A 64THR A 20LEU A 11 | None | 1.13A | 4pgfA-4gq1A:undetectable | 4pgfA-4gq1A:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ix9 | V-TYPE PROTON ATPASESUBUNIT F (Saccharomycescerevisiae) |
PF01990(ATP-synt_F) | 4 | THR A 29GLU A 31THR A 32LEU A 7 | NoneNoneNoneTRS A 101 (-3.6A) | 0.95A | 4pgfA-4ix9A:undetectable | 4pgfA-4ix9A:13.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jjj | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Thermobifidafusca) |
PF02011(Glyco_hydro_48) | 4 | THR A 174THR A 186HIS A 32LEU A 149 | NoneNoneCBI A 701 ( 4.4A)None | 1.04A | 4pgfA-4jjjA:undetectable | 4pgfA-4jjjA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jjj | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Thermobifidafusca) |
PF02011(Glyco_hydro_48) | 4 | THR A 452THR A 543HIS A 535LEU A 528 | NoneNone ZN A 722 ( 3.2A)None | 0.97A | 4pgfA-4jjjA:undetectable | 4pgfA-4jjjA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l4i | RYANODINE RECEPTOR 2 (Mus musculus) |
PF01365(RYDR_ITPR)PF02815(MIR)PF08709(Ins145_P3_rec) | 4 | THR A 302THR A 301HIS A 261LEU A 316 | None | 1.07A | 4pgfA-4l4iA:undetectable | 4pgfA-4l4iA:20.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 60THR A 63THR A 198HIS A 342LEU A 386 | ADN A 501 (-2.8A)ADN A 501 (-4.5A)NAD A 503 ( 2.9A)ADN A 501 ( 3.7A)ADN A 501 ( 4.7A) | 0.23A | 4pgfA-4lvcA:59.5 | 4pgfA-4lvcA:57.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nov | XYLOSIDASE/ARABINOFURANOSIDASE XSA43E (Butyrivibrioproteoclasticus) |
PF04616(Glyco_hydro_43) | 4 | THR A 38THR A 22HIS A 12LEU A 36 | None | 1.13A | 4pgfA-4novA:undetectable | 4pgfA-4novA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pxq | D-GLUCURONYL C5EPIMERASE B (Danio rerio) |
PF06662(C5-epim_C) | 4 | THR A 343GLU A 282THR A 281LEU A 326 | None | 0.99A | 4pgfA-4pxqA:undetectable | 4pgfA-4pxqA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q05 | ESTERASE E25 (unculturedbacterium) |
PF07859(Abhydrolase_3) | 4 | GLU A 323THR A 324THR A 214HIS A 312 | None | 0.96A | 4pgfA-4q05A:5.7 | 4pgfA-4q05A:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qjy | GH127BETA-L-ARABINOFURANOSIDASE (Geobacillusstearothermophilus) |
PF07944(Glyco_hydro_127) | 4 | THR A 442THR A 8HIS A 433LEU A 430 | None | 0.90A | 4pgfA-4qjyA:undetectable | 4pgfA-4qjyA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r7f | UNCHARACTERIZEDPROTEIN (Parabacteroidesmerdae) |
PF17116(DUF5103) | 4 | THR A 115THR A 114HIS A 315LEU A 359 | None | 1.04A | 4pgfA-4r7fA:undetectable | 4pgfA-4r7fA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4usf | STE20-LIKESERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 4 | THR A 224THR A 283HIS A 147LEU A 171 | None | 0.96A | 4pgfA-4usfA:undetectable | 4pgfA-4usfA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xwl | EXOGLUCANASE S (Clostridiumcellulovorans) |
PF02011(Glyco_hydro_48) | 4 | THR A 172THR A 184HIS A 31LEU A 150 | None | 1.13A | 4pgfA-4xwlA:undetectable | 4pgfA-4xwlA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a2r | ANGIOTENSIN-CONVERTING ENZYME (Drosophilamelanogaster) |
PF01401(Peptidase_M2) | 4 | THR A 40GLU A 43THR A 44HIS A 394 | None | 0.99A | 4pgfA-5a2rA:undetectable | 4pgfA-5a2rA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a7v | PUTATIVE GLYCOSIDASEPH117-RELATED (Bacteroidesthetaiotaomicron) |
PF04041(Glyco_hydro_130) | 4 | THR B 148GLU B 150HIS B 181LEU B 238 | None | 1.14A | 4pgfA-5a7vB:undetectable | 4pgfA-5a7vB:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5all | SOLUBLE EPOXIDEHYDROLASE (Homo sapiens) |
PF00561(Abhydrolase_1)PF13419(HAD_2) | 4 | THR A 125GLU A 152THR A 123LEU A 136 | None | 1.01A | 4pgfA-5allA:5.4 | 4pgfA-5allA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c92 | KELCHDOMAIN-CONTAININGPROTEIN (Colletotrichumgraminicola) |
PF01344(Kelch_1)PF09118(DUF1929) | 4 | THR A 49THR A 47THR A 76LEU A 29 | None | 1.05A | 4pgfA-5c92A:undetectable | 4pgfA-5c92A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5czz | CRISPR-ASSOCIATEDENDONUCLEASE CAS9 (Staphylococcusaureus) |
PF13395(HNH_4)PF16592(Cas9_REC) | 4 | THR A 512THR A 511HIS A 527LEU A 547 | None | 0.87A | 4pgfA-5czzA:undetectable | 4pgfA-5czzA:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d7a | TRAF2 ANDNCK-INTERACTINGPROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 4 | THR A 222THR A 280HIS A 145LEU A 169 | THR A 222 ( 0.8A)THR A 280 ( 0.8A)HIS A 145 ( 1.0A)LEU A 169 ( 0.6A) | 0.84A | 4pgfA-5d7aA:undetectable | 4pgfA-5d7aA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dld | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Burkholderiavietnamiensis) |
PF02350(Epimerase_2) | 4 | GLU A 316THR A 173HIS A 94LEU A 121 | None | 1.00A | 4pgfA-5dldA:6.1 | 4pgfA-5dldA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5doz | JAMJ (Lyngbyamajuscula) |
PF08240(ADH_N)PF13602(ADH_zinc_N_2) | 4 | GLU A 213THR A 215THR A 182HIS A 158 | None | 1.11A | 4pgfA-5dozA:9.7 | 4pgfA-5dozA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e25 | BRANCHED-CHAINAMINOTRANSFERASE (Geoglobusacetivorans) |
PF01063(Aminotran_4) | 4 | GLU A 286THR A 283THR A 246LEU A 219 | None | 1.13A | 4pgfA-5e25A:undetectable | 4pgfA-5e25A:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fhx | INTERLEUKIN-4 (Homo sapiens) |
PF00727(IL4) | 4 | THR A 39GLU A 43THR A 44THR A 30 | None | 1.14A | 4pgfA-5fhxA:undetectable | 4pgfA-5fhxA:16.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k13 | RETINOIC ACIDRECEPTOR ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 4 | THR A 397THR A 306HIS A 298LEU A 220 | None | 0.93A | 4pgfA-5k13A:undetectable | 4pgfA-5k13A:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nfq | EPOXIDE HYDROLASEBELONGING TOALPHA/BETA HYDROLASESUPERFAMILYMETAGENOMIC FROMTOMSK SAMPLE (metagenome) |
no annotation | 4 | THR A 97GLU A 121THR A 268LEU A 295 | None | 1.15A | 4pgfA-5nfqA:4.7 | 4pgfA-5nfqA:12.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nz7 | CELLODEXTRINPHOSPHORYLASE (Ruminiclostridiumthermocellum) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 4 | THR A 281THR A 283THR A 364HIS A 367 | None | 1.08A | 4pgfA-5nz7A:undetectable | 4pgfA-5nz7A:18.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5utu | ADENOSYLHOMOCYSTEINASE (Cryptosporidiumparvum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 55GLU A 57THR A 58THR A 212LEU A 404 | SAH A 502 (-2.7A)SAH A 502 (-3.7A)SAH A 502 (-4.2A)NAD A 501 ( 4.1A)SAH A 502 ( 4.7A) | 0.40A | 4pgfA-5utuA:53.5 | 4pgfA-5utuA:47.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5v96 | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE (Naegleriafowleri) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 61GLU A 63THR A 64THR A 198LEU A 389 | ADN A 502 (-2.9A)ADN A 502 (-3.6A)ADN A 502 (-4.4A)NAD A 501 ( 2.9A)ADN A 502 ( 4.7A) | 0.18A | 4pgfA-5v96A:58.8 | 4pgfA-5v96A:56.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 57GLU A 59THR A 60THR A 157 | 9W4 A 502 (-2.9A)9W4 A 502 (-3.8A)NoneNone | 0.62A | 4pgfA-5w4bA:55.9 | 4pgfA-5w4bA:99.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yj6 | DOCKERIN TYPE IREPEAT-CONTAININGPROTEIN (Ruminiclostridiumthermocellum) |
no annotation | 4 | THR A 205THR A 217HIS A 68LEU A 185 | None | 1.06A | 4pgfA-5yj6A:undetectable | 4pgfA-5yj6A:12.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6aph | ADENOSYLHOMOCYSTEINASE (Elizabethkingiaanophelis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | THR A 60THR A 63THR A 162HIS A 306LEU A 352 | ADN A 501 (-2.8A)ADN A 501 (-4.5A)NAD A 500 ( 2.9A)ADN A 501 ( 3.7A)ADN A 501 ( 4.8A) | 0.18A | 4pgfA-6aphA:64.0 | 4pgfA-6aphA:66.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6brd | RIFAMPINMONOOXYGENASE (Streptomycesvenezuelae) |
no annotation | 4 | GLU A 173THR A 174THR A 335HIS A 282 | None | 1.10A | 4pgfA-6brdA:undetectable | 4pgfA-6brdA:9.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6chj | DIACYLGLYCEROLO-ACYLTRANSFERASE (Marinobacterhydrocarbonoclasticus) |
no annotation | 4 | GLU A 422THR A 415THR A 132LEU A 395 | None | 1.10A | 4pgfA-6chjA:undetectable | 4pgfA-6chjA:12.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eux | POLYMERASE BASICPROTEIN 2 (Influenza Bvirus) |
no annotation | 4 | THR A 482GLU A 461HIS A 366LEU A 387 | None | 1.11A | 4pgfA-6euxA:undetectable | 4pgfA-6euxA:10.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f3m | - (-) |
no annotation | 5 | THR B 63THR B 66THR B 165HIS B 323LEU B 376 | ADN B 502 (-2.8A)ADN B 502 (-4.6A)NAD B 501 ( 2.8A) ZN B 505 (-3.2A)ADN B 502 ( 4.8A) | 0.26A | 4pgfA-6f3mB:57.1 | 4pgfA-6f3mB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbn | - (-) |
no annotation | 5 | THR A 58THR A 61THR A 160HIS A 304LEU A 350 | ADN A 501 (-2.8A)ADN A 501 (-4.6A)NAD A 502 ( 2.8A)ADN A 501 ( 3.6A)ADN A 501 ( 4.7A) | 0.21A | 4pgfA-6gbnA:64.1 | 4pgfA-6gbnA:undetectable |