SIMILAR PATTERNS OF AMINO ACIDS FOR 4PFJ_A_ADNA502_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1atj | PEROXIDASE C1A (Armoraciarusticana) |
PF00141(peroxidase) | 4 | GLU A 25THR A 21LEU A 54SER A 108 | None | 0.88A | 4pfjA-1atjA:undetectable | 4pfjA-1atjA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1djp | GLUTAMINASE-ASPARAGINASE (Pseudomonas sp.7A) |
PF00710(Asparaginase) | 4 | GLU A1104THR A1020ASN A1176SER A1067 | NoneDO2 A4000 (-2.1A)NoneDO2 A4000 (-2.4A) | 1.13A | 4pfjA-1djpA:2.9 | 4pfjA-1djpA:25.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dms | DMSO REDUCTASE (Rhodobactercapsulatus) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 4 | GLU A 530HIS A 123LEU A 128SER A 540 | None | 0.94A | 4pfjA-1dmsA:2.8 | 4pfjA-1dmsA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g8k | ARSENITE OXIDASE (Alcaligenesfaecalis) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 4 | THR A 503THR A 511LEU A 142SER A 477 | None | 1.07A | 4pfjA-1g8kA:undetectable | 4pfjA-1g8kA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i5p | PESTICIDIAL CRYSTALPROTEIN CRY2AA (Bacillusthuringiensis) |
PF03944(Endotoxin_C)PF03945(Endotoxin_N)PF09131(Endotoxin_mid) | 4 | GLU A 98THR A 97LEU A 117ASN A 114 | None | 1.15A | 4pfjA-1i5pA:undetectable | 4pfjA-1i5pA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kho | ALPHA-TOXIN (Clostridiumperfringens) |
PF00882(Zn_dep_PLPC)PF01477(PLAT) | 4 | GLU A 289THR A 291THR A 272ASN A 364 | None | 1.11A | 4pfjA-1khoA:undetectable | 4pfjA-1khoA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kxh | ALPHA-AMYLASE (Pseudoalteromonashaloplanktis) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C) | 4 | GLU A 222THR A 221THR A 217SER A 255 | None CL A 900 ( 4.4A)NoneNone | 1.07A | 4pfjA-1kxhA:undetectable | 4pfjA-1kxhA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lxy | ARGININE DEIMINASE (Mycoplasmaarginini) |
PF02274(Amidinotransf) | 4 | GLU A 81THR A 82THR A 200LEU A 403 | None | 1.10A | 4pfjA-1lxyA:undetectable | 4pfjA-1lxyA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mtp | SERINE PROTEINASEINHIBITOR (SERPIN),CHAIN A (Thermobifidafusca) |
PF00079(Serpin) | 4 | THR A 318HIS A 12LEU A 69SER A 85 | None | 0.99A | 4pfjA-1mtpA:undetectable | 4pfjA-1mtpA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n5x | XANTHINEDEHYDROGENASE (Bos taurus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 4 | GLU A1065THR A1066THR A1044HIS A 579 | None | 1.07A | 4pfjA-1n5xA:undetectable | 4pfjA-1n5xA:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p91 | RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE A (Escherichiacoli) |
PF13847(Methyltransf_31) | 4 | GLU A 80THR A 176HIS A 263LEU A 210 | None | 1.09A | 4pfjA-1p91A:3.8 | 4pfjA-1p91A:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r1a | HUMAN RHINOVIRUS 1ACOAT PROTEIN(SUBUNIT VP2)HUMAN RHINOVIRUS 1ACOAT PROTEIN(SUBUNIT VP3) (Rhinovirus A) |
PF00073(Rhv) | 4 | THR 3 227THR 3 92LEU 2 179ASN 2 182 | None | 0.99A | 4pfjA-1r1a3:undetectable | 4pfjA-1r1a3:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v4a | GLUTAMATE-AMMONIA-LIGASEADENYLYLTRANSFERASE (Escherichiacoli) |
PF03710(GlnE)PF08335(GlnD_UR_UTase) | 4 | GLU A 381THR A 392LEU A 417SER A 386 | None | 1.04A | 4pfjA-1v4aA:undetectable | 4pfjA-1v4aA:21.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1v8b | ADENOSYLHOMOCYSTEINASE (Plasmodiumfalciparum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | GLU A 58THR A 201LEU A 389ASN A 391SER A 406 | ADN A 502 (-3.6A)NAD A 501 ( 2.8A)NAD A 501 ( 3.8A)NAD A 501 (-3.0A)ADN A 502 ( 4.5A) | 0.56A | 4pfjA-1v8bA:56.8 | 4pfjA-1v8bA:51.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vbj | PROSTAGLANDIN FSYNTHASE (Trypanosomabrucei) |
PF00248(Aldo_ket_red) | 4 | GLU A 32THR A 35THR A 76LEU A 101 | None | 1.13A | 4pfjA-1vbjA:undetectable | 4pfjA-1vbjA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wcg | THIOGLUCOSIDASE (Brevicorynebrassicae) |
PF00232(Glyco_hydro_1) | 4 | GLU A 364THR A 300HIS A 202LEU A 199 | None | 1.09A | 4pfjA-1wcgA:undetectable | 4pfjA-1wcgA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xzw | PURPLE ACIDPHOSPHATASE (Ipomoea batatas) |
PF00149(Metallophos)PF14008(Metallophos_C)PF16656(Pur_ac_phosph_N) | 4 | THR A 72THR A 224HIS A 226SER A 43 | None | 1.13A | 4pfjA-1xzwA:undetectable | 4pfjA-1xzwA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zcj | PEROXISOMALBIFUNCTIONAL ENZYME (Rattusnorvegicus) |
PF00725(3HCDH)PF02737(3HCDH_N) | 4 | GLU A 496LEU A 691ASN A 685SER A 499 | None | 0.99A | 4pfjA-1zcjA:3.7 | 4pfjA-1zcjA:23.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2atm | HYALURONOGLUCOSAMINIDASE (Vespulavulgaris) |
PF01630(Glyco_hydro_56) | 4 | GLU A 284THR A 281ASN A 187SER A 259 | None | 1.10A | 4pfjA-2atmA:undetectable | 4pfjA-2atmA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bkx | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Bacillussubtilis) |
PF01182(Glucosamine_iso) | 4 | GLU A 159THR A 161THR A 146HIS A 153 | None | 1.07A | 4pfjA-2bkxA:undetectable | 4pfjA-2bkxA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bx7 | DIHYDROOROTATEDEHYDROGENASE (Lactococcuslactis) |
PF01180(DHO_dh) | 4 | GLU A 147THR A 146LEU A 239ASN A 182 | None | 1.09A | 4pfjA-2bx7A:undetectable | 4pfjA-2bx7A:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cb0 | GLUCOSAMINE-FRUCTOSE-6-PHOSPHATEAMINOTRANSFERASE (Pyrococcusfuriosus) |
PF01380(SIS) | 4 | THR A 290THR A 222HIS A 250LEU A 266 | None | 1.08A | 4pfjA-2cb0A:4.2 | 4pfjA-2cb0A:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ew1 | RAS-RELATED PROTEINRAB-30 (Homo sapiens) |
PF00071(Ras) | 4 | GLU A 149THR A 150THR A 116LEU A 99 | None | 1.06A | 4pfjA-2ew1A:3.7 | 4pfjA-2ew1A:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i2x | METHYLTRANSFERASE 1 (Methanosarcinabarkeri) |
PF12176(MtaB) | 4 | GLU A 316THR A 85LEU A 58SER A 314 | NoneNoneNoneB13 B 500 ( 3.8A) | 1.04A | 4pfjA-2i2xA:undetectable | 4pfjA-2i2xA:25.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pfe | ALKALINE SERINEPROTEASE (Thermobifidafusca) |
PF00089(Trypsin) | 4 | THR A 244LEU A 235ASN A 232SER A 207 | None | 1.15A | 4pfjA-2pfeA:undetectable | 4pfjA-2pfeA:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ph5 | HOMOSPERMIDINESYNTHASE (Legionellapneumophila) |
PF03435(Sacchrp_dh_NADP)PF16653(Sacchrp_dh_C) | 4 | THR A 300THR A 155LEU A 142SER A 164 | None | 1.15A | 4pfjA-2ph5A:8.0 | 4pfjA-2ph5A:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vmf | BETA-MANNOSIDASE (Bacteroidesthetaiotaomicron) |
PF00703(Glyco_hydro_2) | 4 | GLU A 90THR A 206HIS A 60LEU A 63 | EDO A1875 (-3.3A)NoneNoneNone | 1.15A | 4pfjA-2vmfA:undetectable | 4pfjA-2vmfA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wmh | FUCOLECTIN-RELATEDPROTEIN (Streptococcuspneumoniae) |
PF08306(Glyco_hydro_98M)PF08307(Glyco_hydro_98C) | 4 | THR A 135HIS A 170LEU A 167ASN A 159 | None | 0.93A | 4pfjA-2wmhA:undetectable | 4pfjA-2wmhA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xrm | INTRACELLULARSUBTILISIN PROTEASE (Bacillusclausii) |
PF00082(Peptidase_S8) | 4 | GLU A 98THR A 237LEU A 112SER A 101 | NoneNoneNone NA A 401 (-4.0A) | 1.13A | 4pfjA-2xrmA:4.8 | 4pfjA-2xrmA:22.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | THR A 74THR A 219HIS A 363LEU A 407ASN A 409SER A 424 | ADN A 500 (-4.5A)NAD A 550 ( 2.8A)ADN A 500 ( 3.7A)NAD A 550 (-4.2A)NAD A 550 (-3.0A)ADN A 500 ( 4.5A) | 0.23A | 4pfjA-3ce6A:57.9 | 4pfjA-3ce6A:54.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eeg | 2-ISOPROPYLMALATESYNTHASE (Cytophagahutchinsonii) |
PF00682(HMGL-like) | 4 | THR A 211THR A 259HIS A 263LEU A 266 | None | 1.06A | 4pfjA-3eegA:undetectable | 4pfjA-3eegA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f1k | UNCHARACTERIZEDOXIDOREDUCTASE YCIK (Escherichiacoli) |
PF00106(adh_short) | 4 | GLU A 46THR A 18LEU A 82SER A 21 | NoneNoneNoneNAP A 300 ( 4.1A) | 1.13A | 4pfjA-3f1kA:8.5 | 4pfjA-3f1kA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fj4 | MUCONATECYCLOISOMERASE (Pseudomonasprotegens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | THR A 143HIS A 24LEU A 26ASN A 202 | MUC A 383 (-3.0A)MUC A 383 (-4.1A)NoneMUC A 383 ( 4.0A) | 1.09A | 4pfjA-3fj4A:undetectable | 4pfjA-3fj4A:22.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | THR A 57THR A 156HIS A 300LEU A 343ASN A 345SER A 360 | ADN A 438 (-4.6A)NAD A 439 ( 3.0A)ADN A 438 ( 4.0A)NAD A 439 ( 4.0A)NAD A 439 (-3.1A)ADN A 438 ( 4.6A) | 0.65A | 4pfjA-3g1uA:62.5 | 4pfjA-3g1uA:70.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | THR A 67THR A 200HIS A 344LEU A 385ASN A 387SER A 402 | RAB A 602 (-4.5A)NAD A 601 ( 2.9A)RAB A 602 ( 3.5A)NAD A 601 ( 4.1A)NAD A 601 (-3.0A)None | 0.32A | 4pfjA-3glqA:59.8 | 4pfjA-3glqA:56.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h9u | ADENOSYLHOMOCYSTEINASE (Trypanosomabrucei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | THR A 57THR A 156HIS A 300LEU A 343ASN A 345SER A 360 | ADN A 439 (-4.7A)NAD A 438 (-3.8A)NoneNAD A 438 (-4.0A)NAD A 438 (-2.9A)None | 0.53A | 4pfjA-3h9uA:64.2 | 4pfjA-3h9uA:71.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4k | MUCONATE LACTONIZINGENZYME (Corynebacteriumglutamicum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | GLU A 52THR A 311HIS A 24LEU A 20 | GLU A 52 ( 0.6A)THR A 311 ( 0.8A)HIS A 24 ( 1.0A)LEU A 20 ( 0.6A) | 1.13A | 4pfjA-3i4kA:undetectable | 4pfjA-3i4kA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m70 | TELLURITE RESISTANCEPROTEIN TEHB HOMOLOG (Haemophilusinfluenzae) |
PF03848(TehB)PF09313(DUF1971) | 4 | THR A 280HIS A 265LEU A 264SER A 190 | None | 1.08A | 4pfjA-3m70A:7.0 | 4pfjA-3m70A:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3moi | PROBABLEDEHYDROGENASE (Bordetellabronchiseptica) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | GLU A 347THR A 344HIS A 77LEU A 97 | None | 0.97A | 4pfjA-3moiA:4.2 | 4pfjA-3moiA:23.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n58 | ADENOSYLHOMOCYSTEINASE (Brucellaabortus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | THR A 60THR A 193HIS A 337LEU A 378ASN A 380SER A 395 | ADN A 500 (-4.6A)NAD A 550 ( 3.0A)ADN A 500 ( 3.6A)NAD A 550 (-4.3A)NAD A 550 (-3.0A)ADN A 500 ( 4.4A) | 0.33A | 4pfjA-3n58A:30.1 | 4pfjA-3n58A:58.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3no3 | GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE (Parabacteroidesdistasonis) |
PF03009(GDPD) | 4 | GLU A 48LEU A 96ASN A 98SER A 58 | None | 1.09A | 4pfjA-3no3A:undetectable | 4pfjA-3no3A:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3olq | UNIVERSAL STRESSPROTEIN E (Proteusmirabilis) |
PF00582(Usp) | 4 | THR A 285HIS A 226ASN A 173SER A 278 | None | 1.06A | 4pfjA-3olqA:2.5 | 4pfjA-3olqA:20.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | THR A 67THR A 206HIS A 350LEU A 395ASN A 397SER A 412 | ADE A 506 (-4.5A)NAD A 501 (-2.8A)NoneNAD A 501 (-4.2A)NAD A 501 (-3.0A)None | 0.44A | 4pfjA-3oneA:29.9 | 4pfjA-3oneA:55.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oth | CALG1 (Micromonosporaechinospora) |
PF00201(UDPGT)PF03033(Glyco_transf_28) | 4 | GLU A 117THR A 14THR A 32LEU A 102 | None | 0.97A | 4pfjA-3othA:4.2 | 4pfjA-3othA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pf2 | CELL WALL SURFACEANCHOR FAMILYPROTEIN (Streptococcusagalactiae) |
PF16569(GramPos_pilinBB)PF16570(GramPos_pilinD3) | 4 | THR A 380LEU A 417ASN A 421SER A 493 | None | 1.11A | 4pfjA-3pf2A:undetectable | 4pfjA-3pf2A:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pf7 | BENZOYL-COAOXYGENASE COMPONENTB (Azoarcusevansii) |
no annotation | 4 | THR A 197LEU A 143ASN A 147SER A 181 | None | 1.00A | 4pfjA-3pf7A:undetectable | 4pfjA-3pf7A:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pvc | TRNA5-METHYLAMINOMETHYL-2-THIOURIDINEBIOSYNTHESISBIFUNCTIONAL PROTEINMNMC (Yersinia pestis) |
PF01266(DAO)PF05430(Methyltransf_30) | 4 | GLU A 64THR A 65THR A 201ASN A 46 | None | 0.99A | 4pfjA-3pvcA:3.8 | 4pfjA-3pvcA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r20 | CYTIDYLATE KINASE (Mycolicibacteriumsmegmatis) |
PF02224(Cytidylate_kin) | 4 | GLU A 130THR A 36THR A 136LEU A 194 | DPO A 230 ( 4.8A)NoneNoneNone | 1.11A | 4pfjA-3r20A:2.7 | 4pfjA-3r20A:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sr6 | XANTHINEDEHYDROGENASE/OXIDASE (Bos taurus) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 4 | GLU C1065THR C1066THR C1044HIS C 579 | None | 1.10A | 4pfjA-3sr6C:undetectable | 4pfjA-3sr6C:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tdn | FLR SYMMETRICALPHA-BETA TIMBARREL (syntheticconstruct) |
PF00977(His_biosynth) | 4 | GLU A 64THR A 63THR A 57SER A 51 | None | 1.12A | 4pfjA-3tdnA:undetectable | 4pfjA-3tdnA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tk1 | MEMBRANEATPASE/PROTEINKINASE (Mycolicibacteriumthermoresistibile) |
PF03308(ArgK) | 4 | GLU A 151THR A 152THR A 168LEU A 247 | None | 1.05A | 4pfjA-3tk1A:undetectable | 4pfjA-3tk1A:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uto | TWITCHIN (Caenorhabditiselegans) |
PF00041(fn3)PF00069(Pkinase)PF07679(I-set) | 4 | GLU A 477THR A 301HIS A 275LEU A 265 | FLC A 573 ( 4.7A)NoneNoneNone | 1.02A | 4pfjA-3utoA:undetectable | 4pfjA-3utoA:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3viu | PHOSPHORIBOSYLFORMYLGLYCINAMIDINESYNTHASE 2 (Thermusthermophilus) |
PF00586(AIRS)PF02769(AIRS_C) | 4 | THR A 504LEU A 172ASN A 174SER A 47 | None | 0.97A | 4pfjA-3viuA:undetectable | 4pfjA-3viuA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w0l | GLUCOKINASEREGULATORY PROTEIN (Xenopus laevis) |
no annotation | 4 | THR B 109LEU B 514ASN B 511SER B 144 | F6R B 701 (-3.7A)NoneNoneNone | 1.05A | 4pfjA-3w0lB:3.3 | 4pfjA-3w0lB:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w6q | TYROSINASE (Aspergillusoryzae) |
PF00264(Tyrosinase) | 4 | GLU A 44THR A 30LEU A 169ASN A 191 | None | 1.12A | 4pfjA-3w6qA:undetectable | 4pfjA-3w6qA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wvj | BETA-GLUCANASE (Ruminiclostridiumthermocellum) |
PF00722(Glyco_hydro_16) | 4 | GLU A 50THR A 97LEU A 78SER A 46 | None | 1.14A | 4pfjA-3wvjA:undetectable | 4pfjA-3wvjA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zeu | PROBABLE TRNATHREONYLCARBAMOYLADENOSINE BIOSYNTHESISPROTEIN GCP (Salmonellaenterica) |
PF00814(Peptidase_M22) | 4 | THR B 79THR B 299LEU B 29ASN B 27 | NoneAGS B1342 (-4.1A)NoneNone | 1.11A | 4pfjA-3zeuB:undetectable | 4pfjA-3zeuB:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ckb | MRNA-CAPPING ENZYMECATALYTIC SUBUNIT (Vaccinia virus) |
PF03291(Pox_MCEL)PF10640(Pox_ATPase-GT) | 4 | THR A 756HIS A 682ASN A 550SER A 740 | NoneNoneSAH A1845 (-4.1A)None | 0.97A | 4pfjA-4ckbA:5.2 | 4pfjA-4ckbA:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dvj | PUTATIVEZINC-DEPENDENTALCOHOLDEHYDROGENASEPROTEIN (Rhizobium etli) |
PF08240(ADH_N)PF13602(ADH_zinc_N_2) | 4 | THR A 209LEU A 344ASN A 328SER A 186 | None | 1.09A | 4pfjA-4dvjA:9.7 | 4pfjA-4dvjA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ft2 | DNA(CYTOSINE-5)-METHYLTRANSFERASE 1 (Zea mays) |
PF00145(DNA_methylase)PF00385(Chromo)PF01426(BAH) | 4 | GLU A 559THR A 370HIS A 388LEU A 384 | None | 1.13A | 4pfjA-4ft2A:2.3 | 4pfjA-4ft2A:19.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g1b | FLAVOHEMOGLOBIN (Saccharomycescerevisiae) |
PF00042(Globin)PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 4 | GLU A 341THR A 338HIS A 374LEU A 349 | None | 0.97A | 4pfjA-4g1bA:4.0 | 4pfjA-4g1bA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h59 | IRON-COMPOUND ABCTRANSPORTER, IRONCOMPOUND-BINDINGPROTEIN (Streptococcuspneumoniae) |
PF01497(Peripla_BP_2) | 4 | THR A 60HIS A 66LEU A 70SER A 124 | None | 1.10A | 4pfjA-4h59A:3.3 | 4pfjA-4h59A:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i4k | UNCHARACTERIZEDPROTEIN SGCJ (Streptomycesglobisporus) |
PF14534(DUF4440) | 4 | THR A 75HIS A 63LEU A 49ASN A 134 | NoneCIT A 201 (-3.6A)PG4 A 202 ( 4.6A)PG4 A 202 (-3.4A) | 1.02A | 4pfjA-4i4kA:undetectable | 4pfjA-4i4kA:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i9c | RESPONSE REGULATORASPARTATEPHOSPHATASE F (Bacillussubtilis) |
PF12895(ANAPC3)PF13424(TPR_12) | 4 | GLU A 149LEU A 230ASN A 227SER A 160 | None | 1.04A | 4pfjA-4i9cA:undetectable | 4pfjA-4i9cA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kf6 | GLYCOLIPID TRANSFERPROTEINDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF08718(GLTP) | 4 | GLU A 123THR A 134LEU A 172SER A 141 | None | 0.96A | 4pfjA-4kf6A:undetectable | 4pfjA-4kf6A:18.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | THR A 63THR A 198HIS A 342LEU A 383ASN A 385SER A 400 | ADN A 501 (-4.5A)NAD A 503 ( 2.9A)ADN A 501 ( 3.7A)NAD A 503 ( 3.9A)NAD A 503 (-3.1A)ADN A 501 ( 4.7A) | 0.52A | 4pfjA-4lvcA:60.0 | 4pfjA-4lvcA:57.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n6k | TRAP DICARBOXYLATETRANSPORTER-DCTPSUBUNIT (Desulfovibriosalexigens) |
PF03480(DctP) | 4 | THR A 229THR A 235HIS A 237LEU A 185 | None | 1.04A | 4pfjA-4n6kA:undetectable | 4pfjA-4n6kA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o9x | TCDB2, TCCC3 (Photorhabdusluminescens) |
PF03534(SpvB)PF12255(TcdB_toxin_midC)PF12256(TcdB_toxin_midN) | 4 | THR A1736HIS A1675LEU A1677SER A1739 | None | 0.93A | 4pfjA-4o9xA:undetectable | 4pfjA-4o9xA:11.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4up5 | PYGOPUS HOMOLOG 2,B-CELL CLL/LYMPHOMA9-LIKE PROTEIN (Homo sapiens) |
PF00628(PHD) | 4 | GLU A 372THR A 371THR A 362LEU A1251 | None | 0.88A | 4pfjA-4up5A:undetectable | 4pfjA-4up5A:9.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4usf | STE20-LIKESERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 4 | THR A 224THR A 283HIS A 147LEU A 146 | None | 1.14A | 4pfjA-4usfA:undetectable | 4pfjA-4usfA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xq6 | DIHYDROOROTATEDEHYDROGENASE(QUINONE) (Mycobacteriumtuberculosis) |
PF01180(DHO_dh) | 4 | GLU A 295THR A 315THR A 243LEU A 249 | NoneFMN A 401 (-3.6A)NoneNone | 0.98A | 4pfjA-4xq6A:undetectable | 4pfjA-4xq6A:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysw | XANTHINEDEHYDROGENASE/OXIDASE (Rattusnorvegicus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 4 | GLU A1065THR A1066THR A1044HIS A 579 | None | 1.09A | 4pfjA-4yswA:undetectable | 4pfjA-4yswA:14.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zg7 | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 2 (Homo sapiens) |
PF01033(Somatomedin_B)PF01223(Endonuclease_NS)PF01663(Phosphodiest) | 4 | THR A 499THR A 537LEU A 516ASN A 353 | None | 1.11A | 4pfjA-4zg7A:undetectable | 4pfjA-4zg7A:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5doz | JAMJ (Lyngbyamajuscula) |
PF08240(ADH_N)PF13602(ADH_zinc_N_2) | 4 | GLU A 213THR A 215THR A 182HIS A 158 | None | 1.10A | 4pfjA-5dozA:9.8 | 4pfjA-5dozA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j84 | DIHYDROXY-ACIDDEHYDRATASE (Rhizobiumleguminosarum) |
PF00920(ILVD_EDD) | 4 | THR A 240HIS A 62LEU A 63ASN A 51 | None | 1.14A | 4pfjA-5j84A:3.8 | 4pfjA-5j84A:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k0w | CLASS BCARBAPENEMASE GOB-18 (Elizabethkingiameningoseptica) |
PF00753(Lactamase_B) | 4 | THR A 144THR A 176LEU A 96SER A 134 | None | 0.98A | 4pfjA-5k0wA:undetectable | 4pfjA-5k0wA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m6g | BETA-GLUCOSIDASE (Saccharopolysporaerythraea) |
no annotation | 4 | THR A 449THR A 165LEU A 149ASN A 146 | None | 1.08A | 4pfjA-5m6gA:3.9 | 4pfjA-5m6gA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m6j | NITROPHORIN-7 (Rhodniusprolixus) |
no annotation | 4 | GLU A 49THR A 53THR A 108ASN A 80 | None | 0.88A | 4pfjA-5m6jA:undetectable | 4pfjA-5m6jA:11.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8t | 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACIDOXIDASE (Homo sapiens) |
PF00264(Tyrosinase) | 4 | GLU A 307THR A 191HIS A 227LEU A 231 | None | 1.07A | 4pfjA-5m8tA:undetectable | 4pfjA-5m8tA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o9g | CHROMODOMAIN-CONTAININGPROTEIN 1 (Saccharomycescerevisiae) |
no annotation | 4 | GLU W 611THR W 610HIS W 712LEU W 707 | None | 0.90A | 4pfjA-5o9gW:undetectable | 4pfjA-5o9gW:14.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5owg | PCYX_EBK42635 (marinemetagenome) |
no annotation | 4 | GLU A 12THR A 13LEU A 154SER A 163 | None | 1.03A | 4pfjA-5owgA:undetectable | 4pfjA-5owgA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uj7 | ORIGIN RECOGNITIONCOMPLEX SUBUNIT 1ORIGIN RECOGNITIONCOMPLEX SUBUNIT 4 (Homo sapiens) |
PF00004(AAA)PF09079(Cdc6_C)PF13191(AAA_16)PF14629(ORC4_C) | 4 | THR C 193LEU C 217ASN C 219SER A 828 | None | 1.12A | 4pfjA-5uj7C:undetectable | 4pfjA-5uj7C:21.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5utu | ADENOSYLHOMOCYSTEINASE (Cryptosporidiumparvum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | GLU A 57THR A 58THR A 212LEU A 401ASN A 403SER A 418 | SAH A 502 (-3.7A)SAH A 502 (-4.2A)NAD A 501 ( 4.1A)NAD A 501 (-4.1A)NAD A 501 (-2.9A)SAH A 502 ( 4.5A) | 0.63A | 4pfjA-5utuA:53.8 | 4pfjA-5utuA:47.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5v96 | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE (Naegleriafowleri) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | GLU A 63THR A 64THR A 198LEU A 386ASN A 388SER A 403 | ADN A 502 (-3.6A)ADN A 502 (-4.4A)NAD A 501 ( 2.9A)NAD A 501 (-3.9A)NAD A 501 (-3.1A)ADN A 502 ( 4.6A) | 0.52A | 4pfjA-5v96A:59.2 | 4pfjA-5v96A:56.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vmk | BIFUNCTIONAL PROTEINGLMU (Acinetobacterbaumannii) |
PF00132(Hexapep)PF12804(NTP_transf_3)PF14602(Hexapep_2) | 4 | GLU A 338THR A 321THR A 351SER A 356 | None | 0.87A | 4pfjA-5vmkA:undetectable | 4pfjA-5vmkA:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w11 | GLUCANASE (Thermothelomycesthermophila) |
no annotation | 5 | THR A 247THR A 227LEU A 382ASN A 142SER A 175 | CTR A 506 (-2.7A)CTR A 506 ( 4.9A)NoneNoneNone | 1.42A | 4pfjA-5w11A:undetectable | 4pfjA-5w11A:11.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | GLU A 59THR A 60THR A 157SER A 361 | 9W4 A 502 (-3.8A)NoneNoneNone | 0.56A | 4pfjA-5w4bA:55.8 | 4pfjA-5w4bA:99.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xwz | UNPLACED GENOMICSCAFFOLDSUPERCONT1.36, WHOLEGENOME SHOTGUNSEQUENCE (Cladophialophorabantiana) |
no annotation | 4 | GLU A 21THR A 58LEU A 170SER A 47 | None | 1.13A | 4pfjA-5xwzA:5.5 | 4pfjA-5xwzA:10.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z97 | LACTONASE FORPROTEIN (Rhinocladiellamackenziei) |
no annotation | 4 | GLU A 21THR A 58LEU A 170SER A 47 | None | 1.09A | 4pfjA-5z97A:5.2 | 4pfjA-5z97A:11.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zbh | NEUROPEPTIDE YRECEPTOR TYPE 1,T4LYSOZYME,NEUROPEPTIDE Y RECEPTOR TYPE 1 (Escherichiavirus T4;Homo sapiens) |
no annotation | 4 | THR A 97HIS A 306LEU A 279ASN A 283 | NoneNone9AF A1201 ( 3.9A)9AF A1201 (-3.7A) | 1.11A | 4pfjA-5zbhA:undetectable | 4pfjA-5zbhA:11.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6aph | ADENOSYLHOMOCYSTEINASE (Elizabethkingiaanophelis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 6 | THR A 63THR A 162HIS A 306LEU A 349ASN A 351SER A 366 | ADN A 501 (-4.5A)NAD A 500 ( 2.9A)ADN A 501 ( 3.7A)NAD A 500 ( 4.3A)NAD A 500 (-3.1A)ADN A 501 ( 4.6A) | 0.24A | 4pfjA-6aphA:64.4 | 4pfjA-6aphA:66.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bwm | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY VMEMBER 2 (Oryctolaguscuniculus) |
no annotation | 4 | GLU A 209LEU A 299ASN A 290SER A 213 | None | 1.15A | 4pfjA-6bwmA:undetectable | 4pfjA-6bwmA:10.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c66 | CRISPR-ASSOCIATEDHELICASE, CAS3FAMILYCRISPR-ASSOCIATEDPROTEIN, CSE1 FAMILY (Thermobifidafusca) |
no annotation | 4 | GLU G 106THR G 89THR A 541LEU A 421 | None | 1.12A | 4pfjA-6c66G:undetectable | 4pfjA-6c66G:10.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c7v | - (-) |
no annotation | 4 | GLU A 185THR A 184THR A 178SER A 172 | None | 1.14A | 4pfjA-6c7vA:undetectable | 4pfjA-6c7vA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d0n | CLC-TYPEFLUORIDE/PROTONANTIPORTER (Enterococcuscasseliflavus) |
no annotation | 4 | GLU A 318THR A 306THR A 282LEU A 39 | None | 1.05A | 4pfjA-6d0nA:undetectable | 4pfjA-6d0nA:10.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ekt | P-47 PROTEIN (Clostridiumbotulinum) |
no annotation | 4 | THR A 24THR A 216ASN A 250SER A 213 | None | 1.02A | 4pfjA-6ektA:undetectable | 4pfjA-6ektA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6exs | PEPTIDE ABCTRANSPORTER PERMEASE (Staphylococcushominis) |
no annotation | 4 | THR A 380LEU A 459ASN A 456SER A 386 | None | 1.06A | 4pfjA-6exsA:undetectable | 4pfjA-6exsA:10.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f3m | - (-) |
no annotation | 6 | THR B 66THR B 165HIS B 323LEU B 373ASN B 375SER B 390 | ADN B 502 (-4.6A)NAD B 501 ( 2.8A) ZN B 505 (-3.2A)NAD B 501 ( 3.9A)NAD B 501 (-3.0A)ADN B 502 ( 4.5A) | 0.50A | 4pfjA-6f3mB:57.6 | 4pfjA-6f3mB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g2j | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN4LNADH-UBIQUINONEOXIDOREDUCTASE CHAIN6 (Mus musculus) |
no annotation | 4 | GLU J 76LEU J 87ASN J 85SER K 28 | None | 1.11A | 4pfjA-6g2jJ:undetectable | 4pfjA-6g2jJ:10.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbn | - (-) |
no annotation | 6 | THR A 61THR A 160HIS A 304LEU A 347ASN A 349SER A 364 | ADN A 501 (-4.6A)NAD A 502 ( 2.8A)ADN A 501 ( 3.6A)NAD A 502 (-3.9A)NAD A 502 (-3.1A)ADN A 501 ( 4.7A) | 0.53A | 4pfjA-6gbnA:64.5 | 4pfjA-6gbnA:undetectable |