SIMILAR PATTERNS OF AMINO ACIDS FOR 4PFJ_A_ADNA502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atj PEROXIDASE C1A

(Armoracia
rusticana)
PF00141
(peroxidase)
4 GLU A  25
THR A  21
LEU A  54
SER A 108
None
0.88A 4pfjA-1atjA:
undetectable
4pfjA-1atjA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1djp GLUTAMINASE-ASPARAGI
NASE


(Pseudomonas sp.
7A)
PF00710
(Asparaginase)
4 GLU A1104
THR A1020
ASN A1176
SER A1067
None
DO2  A4000 (-2.1A)
None
DO2  A4000 (-2.4A)
1.13A 4pfjA-1djpA:
2.9
4pfjA-1djpA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dms DMSO REDUCTASE

(Rhodobacter
capsulatus)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
4 GLU A 530
HIS A 123
LEU A 128
SER A 540
None
0.94A 4pfjA-1dmsA:
2.8
4pfjA-1dmsA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
4 THR A 503
THR A 511
LEU A 142
SER A 477
None
1.07A 4pfjA-1g8kA:
undetectable
4pfjA-1g8kA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA


(Bacillus
thuringiensis)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid)
4 GLU A  98
THR A  97
LEU A 117
ASN A 114
None
1.15A 4pfjA-1i5pA:
undetectable
4pfjA-1i5pA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kho ALPHA-TOXIN

(Clostridium
perfringens)
PF00882
(Zn_dep_PLPC)
PF01477
(PLAT)
4 GLU A 289
THR A 291
THR A 272
ASN A 364
None
1.11A 4pfjA-1khoA:
undetectable
4pfjA-1khoA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxh ALPHA-AMYLASE

(Pseudoalteromonas
haloplanktis)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
4 GLU A 222
THR A 221
THR A 217
SER A 255
None
CL  A 900 ( 4.4A)
None
None
1.07A 4pfjA-1kxhA:
undetectable
4pfjA-1kxhA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini)
PF02274
(Amidinotransf)
4 GLU A  81
THR A  82
THR A 200
LEU A 403
None
1.10A 4pfjA-1lxyA:
undetectable
4pfjA-1lxyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A


(Thermobifida
fusca)
PF00079
(Serpin)
4 THR A 318
HIS A  12
LEU A  69
SER A  85
None
0.99A 4pfjA-1mtpA:
undetectable
4pfjA-1mtpA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE


(Bos taurus)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
4 GLU A1065
THR A1066
THR A1044
HIS A 579
None
1.07A 4pfjA-1n5xA:
undetectable
4pfjA-1n5xA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A


(Escherichia
coli)
PF13847
(Methyltransf_31)
4 GLU A  80
THR A 176
HIS A 263
LEU A 210
None
1.09A 4pfjA-1p91A:
3.8
4pfjA-1p91A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP2)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP3)


(Rhinovirus A)
PF00073
(Rhv)
4 THR 3 227
THR 3  92
LEU 2 179
ASN 2 182
None
0.99A 4pfjA-1r1a3:
undetectable
4pfjA-1r1a3:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE


(Escherichia
coli)
PF03710
(GlnE)
PF08335
(GlnD_UR_UTase)
4 GLU A 381
THR A 392
LEU A 417
SER A 386
None
1.04A 4pfjA-1v4aA:
undetectable
4pfjA-1v4aA:
21.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v8b ADENOSYLHOMOCYSTEINA
SE


(Plasmodium
falciparum)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 GLU A  58
THR A 201
LEU A 389
ASN A 391
SER A 406
ADN  A 502 (-3.6A)
NAD  A 501 ( 2.8A)
NAD  A 501 ( 3.8A)
NAD  A 501 (-3.0A)
ADN  A 502 ( 4.5A)
0.56A 4pfjA-1v8bA:
56.8
4pfjA-1v8bA:
51.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbj PROSTAGLANDIN F
SYNTHASE


(Trypanosoma
brucei)
PF00248
(Aldo_ket_red)
4 GLU A  32
THR A  35
THR A  76
LEU A 101
None
1.13A 4pfjA-1vbjA:
undetectable
4pfjA-1vbjA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcg THIOGLUCOSIDASE

(Brevicoryne
brassicae)
PF00232
(Glyco_hydro_1)
4 GLU A 364
THR A 300
HIS A 202
LEU A 199
None
1.09A 4pfjA-1wcgA:
undetectable
4pfjA-1wcgA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE


(Ipomoea batatas)
PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N)
4 THR A  72
THR A 224
HIS A 226
SER A  43
None
1.13A 4pfjA-1xzwA:
undetectable
4pfjA-1xzwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME


(Rattus
norvegicus)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
4 GLU A 496
LEU A 691
ASN A 685
SER A 499
None
0.99A 4pfjA-1zcjA:
3.7
4pfjA-1zcjA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atm HYALURONOGLUCOSAMINI
DASE


(Vespula
vulgaris)
PF01630
(Glyco_hydro_56)
4 GLU A 284
THR A 281
ASN A 187
SER A 259
None
1.10A 4pfjA-2atmA:
undetectable
4pfjA-2atmA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE


(Bacillus
subtilis)
PF01182
(Glucosamine_iso)
4 GLU A 159
THR A 161
THR A 146
HIS A 153
None
1.07A 4pfjA-2bkxA:
undetectable
4pfjA-2bkxA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx7 DIHYDROOROTATE
DEHYDROGENASE


(Lactococcus
lactis)
PF01180
(DHO_dh)
4 GLU A 147
THR A 146
LEU A 239
ASN A 182
None
1.09A 4pfjA-2bx7A:
undetectable
4pfjA-2bx7A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE


(Pyrococcus
furiosus)
PF01380
(SIS)
4 THR A 290
THR A 222
HIS A 250
LEU A 266
None
1.08A 4pfjA-2cb0A:
4.2
4pfjA-2cb0A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew1 RAS-RELATED PROTEIN
RAB-30


(Homo sapiens)
PF00071
(Ras)
4 GLU A 149
THR A 150
THR A 116
LEU A  99
None
1.06A 4pfjA-2ew1A:
3.7
4pfjA-2ew1A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri)
PF12176
(MtaB)
4 GLU A 316
THR A  85
LEU A  58
SER A 314
None
None
None
B13  B 500 ( 3.8A)
1.04A 4pfjA-2i2xA:
undetectable
4pfjA-2i2xA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfe ALKALINE SERINE
PROTEASE


(Thermobifida
fusca)
PF00089
(Trypsin)
4 THR A 244
LEU A 235
ASN A 232
SER A 207
None
1.15A 4pfjA-2pfeA:
undetectable
4pfjA-2pfeA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph5 HOMOSPERMIDINE
SYNTHASE


(Legionella
pneumophila)
PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C)
4 THR A 300
THR A 155
LEU A 142
SER A 164
None
1.15A 4pfjA-2ph5A:
8.0
4pfjA-2ph5A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron)
PF00703
(Glyco_hydro_2)
4 GLU A  90
THR A 206
HIS A  60
LEU A  63
EDO  A1875 (-3.3A)
None
None
None
1.15A 4pfjA-2vmfA:
undetectable
4pfjA-2vmfA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmh FUCOLECTIN-RELATED
PROTEIN


(Streptococcus
pneumoniae)
PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C)
4 THR A 135
HIS A 170
LEU A 167
ASN A 159
None
0.93A 4pfjA-2wmhA:
undetectable
4pfjA-2wmhA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrm INTRACELLULAR
SUBTILISIN PROTEASE


(Bacillus
clausii)
PF00082
(Peptidase_S8)
4 GLU A  98
THR A 237
LEU A 112
SER A 101
None
None
None
NA  A 401 (-4.0A)
1.13A 4pfjA-2xrmA:
4.8
4pfjA-2xrmA:
22.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE


(Mycobacterium
tuberculosis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
6 THR A  74
THR A 219
HIS A 363
LEU A 407
ASN A 409
SER A 424
ADN  A 500 (-4.5A)
NAD  A 550 ( 2.8A)
ADN  A 500 ( 3.7A)
NAD  A 550 (-4.2A)
NAD  A 550 (-3.0A)
ADN  A 500 ( 4.5A)
0.23A 4pfjA-3ce6A:
57.9
4pfjA-3ce6A:
54.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE


(Cytophaga
hutchinsonii)
PF00682
(HMGL-like)
4 THR A 211
THR A 259
HIS A 263
LEU A 266
None
1.06A 4pfjA-3eegA:
undetectable
4pfjA-3eegA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1k UNCHARACTERIZED
OXIDOREDUCTASE YCIK


(Escherichia
coli)
PF00106
(adh_short)
4 GLU A  46
THR A  18
LEU A  82
SER A  21
None
None
None
NAP  A 300 ( 4.1A)
1.13A 4pfjA-3f1kA:
8.5
4pfjA-3f1kA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE


(Pseudomonas
protegens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 THR A 143
HIS A  24
LEU A  26
ASN A 202
MUC  A 383 (-3.0A)
MUC  A 383 (-4.1A)
None
MUC  A 383 ( 4.0A)
1.09A 4pfjA-3fj4A:
undetectable
4pfjA-3fj4A:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE


(Leishmania
major)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
6 THR A  57
THR A 156
HIS A 300
LEU A 343
ASN A 345
SER A 360
ADN  A 438 (-4.6A)
NAD  A 439 ( 3.0A)
ADN  A 438 ( 4.0A)
NAD  A 439 ( 4.0A)
NAD  A 439 (-3.1A)
ADN  A 438 ( 4.6A)
0.65A 4pfjA-3g1uA:
62.5
4pfjA-3g1uA:
70.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE


(Burkholderia
pseudomallei)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
6 THR A  67
THR A 200
HIS A 344
LEU A 385
ASN A 387
SER A 402
RAB  A 602 (-4.5A)
NAD  A 601 ( 2.9A)
RAB  A 602 ( 3.5A)
NAD  A 601 ( 4.1A)
NAD  A 601 (-3.0A)
None
0.32A 4pfjA-3glqA:
59.8
4pfjA-3glqA:
56.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h9u ADENOSYLHOMOCYSTEINA
SE


(Trypanosoma
brucei)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
6 THR A  57
THR A 156
HIS A 300
LEU A 343
ASN A 345
SER A 360
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
NAD  A 438 (-4.0A)
NAD  A 438 (-2.9A)
None
0.53A 4pfjA-3h9uA:
64.2
4pfjA-3h9uA:
71.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4k MUCONATE LACTONIZING
ENZYME


(Corynebacterium
glutamicum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 GLU A  52
THR A 311
HIS A  24
LEU A  20
GLU  A  52 ( 0.6A)
THR  A 311 ( 0.8A)
HIS  A  24 ( 1.0A)
LEU  A  20 ( 0.6A)
1.13A 4pfjA-3i4kA:
undetectable
4pfjA-3i4kA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m70 TELLURITE RESISTANCE
PROTEIN TEHB HOMOLOG


(Haemophilus
influenzae)
PF03848
(TehB)
PF09313
(DUF1971)
4 THR A 280
HIS A 265
LEU A 264
SER A 190
None
1.08A 4pfjA-3m70A:
7.0
4pfjA-3m70A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moi PROBABLE
DEHYDROGENASE


(Bordetella
bronchiseptica)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 GLU A 347
THR A 344
HIS A  77
LEU A  97
None
0.97A 4pfjA-3moiA:
4.2
4pfjA-3moiA:
23.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n58 ADENOSYLHOMOCYSTEINA
SE


(Brucella
abortus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
6 THR A  60
THR A 193
HIS A 337
LEU A 378
ASN A 380
SER A 395
ADN  A 500 (-4.6A)
NAD  A 550 ( 3.0A)
ADN  A 500 ( 3.6A)
NAD  A 550 (-4.3A)
NAD  A 550 (-3.0A)
ADN  A 500 ( 4.4A)
0.33A 4pfjA-3n58A:
30.1
4pfjA-3n58A:
58.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no3 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE


(Parabacteroides
distasonis)
PF03009
(GDPD)
4 GLU A  48
LEU A  96
ASN A  98
SER A  58
None
1.09A 4pfjA-3no3A:
undetectable
4pfjA-3no3A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olq UNIVERSAL STRESS
PROTEIN E


(Proteus
mirabilis)
PF00582
(Usp)
4 THR A 285
HIS A 226
ASN A 173
SER A 278
None
1.06A 4pfjA-3olqA:
2.5
4pfjA-3olqA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE


(Lupinus luteus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
6 THR A  67
THR A 206
HIS A 350
LEU A 395
ASN A 397
SER A 412
ADE  A 506 (-4.5A)
NAD  A 501 (-2.8A)
None
NAD  A 501 (-4.2A)
NAD  A 501 (-3.0A)
None
0.44A 4pfjA-3oneA:
29.9
4pfjA-3oneA:
55.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oth CALG1

(Micromonospora
echinospora)
PF00201
(UDPGT)
PF03033
(Glyco_transf_28)
4 GLU A 117
THR A  14
THR A  32
LEU A 102
None
0.97A 4pfjA-3othA:
4.2
4pfjA-3othA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf2 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN


(Streptococcus
agalactiae)
PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3)
4 THR A 380
LEU A 417
ASN A 421
SER A 493
None
1.11A 4pfjA-3pf2A:
undetectable
4pfjA-3pf2A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf7 BENZOYL-COA
OXYGENASE COMPONENT
B


(Azoarcus
evansii)
no annotation 4 THR A 197
LEU A 143
ASN A 147
SER A 181
None
1.00A 4pfjA-3pf7A:
undetectable
4pfjA-3pf7A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC


(Yersinia pestis)
PF01266
(DAO)
PF05430
(Methyltransf_30)
4 GLU A  64
THR A  65
THR A 201
ASN A  46
None
0.99A 4pfjA-3pvcA:
3.8
4pfjA-3pvcA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r20 CYTIDYLATE KINASE

(Mycolicibacterium
smegmatis)
PF02224
(Cytidylate_kin)
4 GLU A 130
THR A  36
THR A 136
LEU A 194
DPO  A 230 ( 4.8A)
None
None
None
1.11A 4pfjA-3r20A:
2.7
4pfjA-3r20A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E


(Bos taurus)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
4 GLU C1065
THR C1066
THR C1044
HIS C 579
None
1.10A 4pfjA-3sr6C:
undetectable
4pfjA-3sr6C:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdn FLR SYMMETRIC
ALPHA-BETA TIM
BARREL


(synthetic
construct)
PF00977
(His_biosynth)
4 GLU A  64
THR A  63
THR A  57
SER A  51
None
1.12A 4pfjA-3tdnA:
undetectable
4pfjA-3tdnA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk1 MEMBRANE
ATPASE/PROTEIN
KINASE


(Mycolicibacterium
thermoresistibile)
PF03308
(ArgK)
4 GLU A 151
THR A 152
THR A 168
LEU A 247
None
1.05A 4pfjA-3tk1A:
undetectable
4pfjA-3tk1A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uto TWITCHIN

(Caenorhabditis
elegans)
PF00041
(fn3)
PF00069
(Pkinase)
PF07679
(I-set)
4 GLU A 477
THR A 301
HIS A 275
LEU A 265
FLC  A 573 ( 4.7A)
None
None
None
1.02A 4pfjA-3utoA:
undetectable
4pfjA-3utoA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3viu PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 2


(Thermus
thermophilus)
PF00586
(AIRS)
PF02769
(AIRS_C)
4 THR A 504
LEU A 172
ASN A 174
SER A  47
None
0.97A 4pfjA-3viuA:
undetectable
4pfjA-3viuA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE
REGULATORY PROTEIN


(Xenopus laevis)
no annotation 4 THR B 109
LEU B 514
ASN B 511
SER B 144
F6R  B 701 (-3.7A)
None
None
None
1.05A 4pfjA-3w0lB:
3.3
4pfjA-3w0lB:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae)
PF00264
(Tyrosinase)
4 GLU A  44
THR A  30
LEU A 169
ASN A 191
None
1.12A 4pfjA-3w6qA:
undetectable
4pfjA-3w6qA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvj BETA-GLUCANASE

(Ruminiclostridium
thermocellum)
PF00722
(Glyco_hydro_16)
4 GLU A  50
THR A  97
LEU A  78
SER A  46
None
1.14A 4pfjA-3wvjA:
undetectable
4pfjA-3wvjA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP


(Salmonella
enterica)
PF00814
(Peptidase_M22)
4 THR B  79
THR B 299
LEU B  29
ASN B  27
None
AGS  B1342 (-4.1A)
None
None
1.11A 4pfjA-3zeuB:
undetectable
4pfjA-3zeuB:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT


(Vaccinia virus)
PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT)
4 THR A 756
HIS A 682
ASN A 550
SER A 740
None
None
SAH  A1845 (-4.1A)
None
0.97A 4pfjA-4ckbA:
5.2
4pfjA-4ckbA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvj PUTATIVE
ZINC-DEPENDENT
ALCOHOL
DEHYDROGENASE
PROTEIN


(Rhizobium etli)
PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2)
4 THR A 209
LEU A 344
ASN A 328
SER A 186
None
1.09A 4pfjA-4dvjA:
9.7
4pfjA-4dvjA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Zea mays)
PF00145
(DNA_methylase)
PF00385
(Chromo)
PF01426
(BAH)
4 GLU A 559
THR A 370
HIS A 388
LEU A 384
None
1.13A 4pfjA-4ft2A:
2.3
4pfjA-4ft2A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1b FLAVOHEMOGLOBIN

(Saccharomyces
cerevisiae)
PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
4 GLU A 341
THR A 338
HIS A 374
LEU A 349
None
0.97A 4pfjA-4g1bA:
4.0
4pfjA-4g1bA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN


(Streptococcus
pneumoniae)
PF01497
(Peripla_BP_2)
4 THR A  60
HIS A  66
LEU A  70
SER A 124
None
1.10A 4pfjA-4h59A:
3.3
4pfjA-4h59A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4k UNCHARACTERIZED
PROTEIN SGCJ


(Streptomyces
globisporus)
PF14534
(DUF4440)
4 THR A  75
HIS A  63
LEU A  49
ASN A 134
None
CIT  A 201 (-3.6A)
PG4  A 202 ( 4.6A)
PG4  A 202 (-3.4A)
1.02A 4pfjA-4i4kA:
undetectable
4pfjA-4i4kA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F


(Bacillus
subtilis)
PF12895
(ANAPC3)
PF13424
(TPR_12)
4 GLU A 149
LEU A 230
ASN A 227
SER A 160
None
1.04A 4pfjA-4i9cA:
undetectable
4pfjA-4i9cA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf6 GLYCOLIPID TRANSFER
PROTEIN
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF08718
(GLTP)
4 GLU A 123
THR A 134
LEU A 172
SER A 141
None
0.96A 4pfjA-4kf6A:
undetectable
4pfjA-4kf6A:
18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)


(Bradyrhizobium
elkanii)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
6 THR A  63
THR A 198
HIS A 342
LEU A 383
ASN A 385
SER A 400
ADN  A 501 (-4.5A)
NAD  A 503 ( 2.9A)
ADN  A 501 ( 3.7A)
NAD  A 503 ( 3.9A)
NAD  A 503 (-3.1A)
ADN  A 501 ( 4.7A)
0.52A 4pfjA-4lvcA:
60.0
4pfjA-4lvcA:
57.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT


(Desulfovibrio
salexigens)
PF03480
(DctP)
4 THR A 229
THR A 235
HIS A 237
LEU A 185
None
1.04A 4pfjA-4n6kA:
undetectable
4pfjA-4n6kA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens)
PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN)
4 THR A1736
HIS A1675
LEU A1677
SER A1739
None
0.93A 4pfjA-4o9xA:
undetectable
4pfjA-4o9xA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN


(Homo sapiens)
PF00628
(PHD)
4 GLU A 372
THR A 371
THR A 362
LEU A1251
None
0.88A 4pfjA-4up5A:
undetectable
4pfjA-4up5A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
4 THR A 224
THR A 283
HIS A 147
LEU A 146
None
1.14A 4pfjA-4usfA:
undetectable
4pfjA-4usfA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)


(Mycobacterium
tuberculosis)
PF01180
(DHO_dh)
4 GLU A 295
THR A 315
THR A 243
LEU A 249
None
FMN  A 401 (-3.6A)
None
None
0.98A 4pfjA-4xq6A:
undetectable
4pfjA-4xq6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E


(Rattus
norvegicus)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
4 GLU A1065
THR A1066
THR A1044
HIS A 579
None
1.09A 4pfjA-4yswA:
undetectable
4pfjA-4yswA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2


(Homo sapiens)
PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest)
4 THR A 499
THR A 537
LEU A 516
ASN A 353
None
1.11A 4pfjA-4zg7A:
undetectable
4pfjA-4zg7A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doz JAMJ

(Lyngbya
majuscula)
PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2)
4 GLU A 213
THR A 215
THR A 182
HIS A 158
None
1.10A 4pfjA-5dozA:
9.8
4pfjA-5dozA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE


(Rhizobium
leguminosarum)
PF00920
(ILVD_EDD)
4 THR A 240
HIS A  62
LEU A  63
ASN A  51
None
1.14A 4pfjA-5j84A:
3.8
4pfjA-5j84A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0w CLASS B
CARBAPENEMASE GOB-18


(Elizabethkingia
meningoseptica)
PF00753
(Lactamase_B)
4 THR A 144
THR A 176
LEU A  96
SER A 134
None
0.98A 4pfjA-5k0wA:
undetectable
4pfjA-5k0wA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea)
no annotation 4 THR A 449
THR A 165
LEU A 149
ASN A 146
None
1.08A 4pfjA-5m6gA:
3.9
4pfjA-5m6gA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6j NITROPHORIN-7

(Rhodnius
prolixus)
no annotation 4 GLU A  49
THR A  53
THR A 108
ASN A  80
None
0.88A 4pfjA-5m6jA:
undetectable
4pfjA-5m6jA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE


(Homo sapiens)
PF00264
(Tyrosinase)
4 GLU A 307
THR A 191
HIS A 227
LEU A 231
None
1.07A 4pfjA-5m8tA:
undetectable
4pfjA-5m8tA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1


(Saccharomyces
cerevisiae)
no annotation 4 GLU W 611
THR W 610
HIS W 712
LEU W 707
None
0.90A 4pfjA-5o9gW:
undetectable
4pfjA-5o9gW:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owg PCYX_EBK42635

(marine
metagenome)
no annotation 4 GLU A  12
THR A  13
LEU A 154
SER A 163
None
1.03A 4pfjA-5owgA:
undetectable
4pfjA-5owgA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
ORIGIN RECOGNITION
COMPLEX SUBUNIT 4


(Homo sapiens)
PF00004
(AAA)
PF09079
(Cdc6_C)
PF13191
(AAA_16)
PF14629
(ORC4_C)
4 THR C 193
LEU C 217
ASN C 219
SER A 828
None
1.12A 4pfjA-5uj7C:
undetectable
4pfjA-5uj7C:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5utu ADENOSYLHOMOCYSTEINA
SE


(Cryptosporidium
parvum)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
6 GLU A  57
THR A  58
THR A 212
LEU A 401
ASN A 403
SER A 418
SAH  A 502 (-3.7A)
SAH  A 502 (-4.2A)
NAD  A 501 ( 4.1A)
NAD  A 501 (-4.1A)
NAD  A 501 (-2.9A)
SAH  A 502 ( 4.5A)
0.63A 4pfjA-5utuA:
53.8
4pfjA-5utuA:
47.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE


(Naegleria
fowleri)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
6 GLU A  63
THR A  64
THR A 198
LEU A 386
ASN A 388
SER A 403
ADN  A 502 (-3.6A)
ADN  A 502 (-4.4A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.9A)
NAD  A 501 (-3.1A)
ADN  A 502 ( 4.6A)
0.52A 4pfjA-5v96A:
59.2
4pfjA-5v96A:
56.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmk BIFUNCTIONAL PROTEIN
GLMU


(Acinetobacter
baumannii)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
PF14602
(Hexapep_2)
4 GLU A 338
THR A 321
THR A 351
SER A 356
None
0.87A 4pfjA-5vmkA:
undetectable
4pfjA-5vmkA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w11 GLUCANASE

(Thermothelomyces
thermophila)
no annotation 5 THR A 247
THR A 227
LEU A 382
ASN A 142
SER A 175
CTR  A 506 (-2.7A)
CTR  A 506 ( 4.9A)
None
None
None
1.42A 4pfjA-5w11A:
undetectable
4pfjA-5w11A:
11.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w4b ADENOSYLHOMOCYSTEINA
SE


(Homo sapiens)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 GLU A  59
THR A  60
THR A 157
SER A 361
9W4  A 502 (-3.8A)
None
None
None
0.56A 4pfjA-5w4bA:
55.8
4pfjA-5w4bA:
99.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwz UNPLACED GENOMIC
SCAFFOLD
SUPERCONT1.36, WHOLE
GENOME SHOTGUN
SEQUENCE


(Cladophialophora
bantiana)
no annotation 4 GLU A  21
THR A  58
LEU A 170
SER A  47
None
1.13A 4pfjA-5xwzA:
5.5
4pfjA-5xwzA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z97 LACTONASE FOR
PROTEIN


(Rhinocladiella
mackenziei)
no annotation 4 GLU A  21
THR A  58
LEU A 170
SER A  47
None
1.09A 4pfjA-5z97A:
5.2
4pfjA-5z97A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbh NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME,NEUROPEPTID
E Y RECEPTOR TYPE 1


(Escherichia
virus T4;
Homo sapiens)
no annotation 4 THR A  97
HIS A 306
LEU A 279
ASN A 283
None
None
9AF  A1201 ( 3.9A)
9AF  A1201 (-3.7A)
1.11A 4pfjA-5zbhA:
undetectable
4pfjA-5zbhA:
11.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE


(Elizabethkingia
anophelis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
6 THR A  63
THR A 162
HIS A 306
LEU A 349
ASN A 351
SER A 366
ADN  A 501 (-4.5A)
NAD  A 500 ( 2.9A)
ADN  A 501 ( 3.7A)
NAD  A 500 ( 4.3A)
NAD  A 500 (-3.1A)
ADN  A 501 ( 4.6A)
0.24A 4pfjA-6aphA:
64.4
4pfjA-6aphA:
66.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2


(Oryctolagus
cuniculus)
no annotation 4 GLU A 209
LEU A 299
ASN A 290
SER A 213
None
1.15A 4pfjA-6bwmA:
undetectable
4pfjA-6bwmA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY


(Thermobifida
fusca)
no annotation 4 GLU G 106
THR G  89
THR A 541
LEU A 421
None
1.12A 4pfjA-6c66G:
undetectable
4pfjA-6c66G:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7v -

(-)
no annotation 4 GLU A 185
THR A 184
THR A 178
SER A 172
None
1.14A 4pfjA-6c7vA:
undetectable
4pfjA-6c7vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER


(Enterococcus
casseliflavus)
no annotation 4 GLU A 318
THR A 306
THR A 282
LEU A  39
None
1.05A 4pfjA-6d0nA:
undetectable
4pfjA-6d0nA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ekt P-47 PROTEIN

(Clostridium
botulinum)
no annotation 4 THR A  24
THR A 216
ASN A 250
SER A 213
None
1.02A 4pfjA-6ektA:
undetectable
4pfjA-6ektA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE


(Staphylococcus
hominis)
no annotation 4 THR A 380
LEU A 459
ASN A 456
SER A 386
None
1.06A 4pfjA-6exsA:
undetectable
4pfjA-6exsA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-)
no annotation 6 THR B  66
THR B 165
HIS B 323
LEU B 373
ASN B 375
SER B 390
ADN  B 502 (-4.6A)
NAD  B 501 ( 2.8A)
ZN  B 505 (-3.2A)
NAD  B 501 ( 3.9A)
NAD  B 501 (-3.0A)
ADN  B 502 ( 4.5A)
0.50A 4pfjA-6f3mB:
57.6
4pfjA-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6


(Mus musculus)
no annotation 4 GLU J  76
LEU J  87
ASN J  85
SER K  28
None
1.11A 4pfjA-6g2jJ:
undetectable
4pfjA-6g2jJ:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-)
no annotation 6 THR A  61
THR A 160
HIS A 304
LEU A 347
ASN A 349
SER A 364
ADN  A 501 (-4.6A)
NAD  A 502 ( 2.8A)
ADN  A 501 ( 3.6A)
NAD  A 502 (-3.9A)
NAD  A 502 (-3.1A)
ADN  A 501 ( 4.7A)
0.53A 4pfjA-6gbnA:
64.5
4pfjA-6gbnA:
undetectable