SIMILAR PATTERNS OF AMINO ACIDS FOR 4PEV_C_ADNC501_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N) 		3 PRO A  94
VAL A 139
HIS A 137
 None
NHR  A 220 (-4.5A)
None
 0.84A 4pevC-1c3eA:
2.4		 4pevC-1c3eA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chd CHEB METHYLESTERASE

(Salmonella
enterica) 		PF01339
(CheB_methylest) 		3 PRO A 251
VAL A 262
HIS A 265
 None
 0.85A 4pevC-1chdA:
2.3		 4pevC-1chdA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fez PHOSPHONOACETALDEHYD
E HYDROLASE

(Bacillus cereus) 		PF13419
(HAD_2) 		3 PRO A  78
VAL A  57
HIS A  56
 None
 0.84A 4pevC-1fezA:
4.3		 4pevC-1fezA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5c BETA-CARBONIC
ANHYDRASE

(Methanothermobacter
thermautotrophicus) 		PF00484
(Pro_CA) 		3 PRO A 146
VAL A 151
HIS A 152
 None
 0.80A 4pevC-1g5cA:
4.7		 4pevC-1g5cA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksp PROTEIN (DNA
POLYMERASE I-KLENOW
FRAGMENT
(E.C.2.7.7.7))

(Escherichia
coli) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		3 PRO A 549
VAL A 655
HIS A 656
 None
 0.62A 4pevC-1kspA:
undetectable		 4pevC-1kspA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		3 PRO A 500
VAL A 493
HIS A 212
 None
 0.71A 4pevC-1nowA:
undetectable		 4pevC-1nowA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdq CATHEPSIN B

(Bos taurus) 		PF00112
(Peptidase_C1) 		3 PRO A 102
VAL A  89
HIS A 145
 None
 0.84A 4pevC-1qdqA:
undetectable		 4pevC-1qdqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sie POLYOMAVIRUS COAT
PROTEIN VP1

(Mus musculus
polyomavirus 1) 		PF00718
(Polyoma_coat) 		3 PRO A 144
VAL A 290
HIS A 298
 None
None
SIA  A 384 (-3.6A)
 0.83A 4pevC-1sieA:
undetectable		 4pevC-1sieA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2a GLUTATHIONE
TRANSFERASE GST1-6

(Anopheles dirus) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		3 PRO A  47
VAL A  60
HIS A  59
 None
 0.74A 4pevC-1v2aA:
1.7		 4pevC-1v2aA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		3 PRO A 307
VAL A 291
HIS A 292
 None
None
GLC  A 903 (-4.2A)
 0.83A 4pevC-1venA:
undetectable		 4pevC-1venA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Thermotoga
maritima) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 PRO A 127
VAL A 266
HIS A 267
 None
 0.66A 4pevC-1vknA:
4.4		 4pevC-1vknA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm7 RIBOKINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		3 PRO A 177
VAL A 220
HIS A 230
 None
 0.71A 4pevC-1vm7A:
2.9		 4pevC-1vm7A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w52 PANCREATIC LIPASE
RELATED PROTEIN 2

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 PRO X 195
VAL X 174
HIS X 149
 None
 0.68A 4pevC-1w52X:
4.3		 4pevC-1w52X:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2g LIPOATE-PROTEIN
LIGASE A

(Escherichia
coli) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		3 PRO A 287
VAL A 280
HIS A 267
 None
 0.81A 4pevC-1x2gA:
undetectable		 4pevC-1x2gA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		3 PRO A 705
VAL A 587
HIS A 613
 None
 0.64A 4pevC-1xf1A:
2.4		 4pevC-1xf1A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycl S-RIBOSYLHOMOCYSTEIN
ASE

(Bacillus
subtilis) 		PF02664
(LuxS) 		3 PRO A  96
VAL A  24
HIS A  25
 None
 0.77A 4pevC-1yclA:
undetectable		 4pevC-1yclA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB

(Mycobacterium
tuberculosis) 		PF13350
(Y_phosphatase3) 		3 PRO A  70
VAL A  75
HIS A  76
 None
 0.79A 4pevC-1ywfA:
2.6		 4pevC-1ywfA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D

(Methanosarcina
mazei) 		PF01142
(TruD) 		3 PRO A 205
VAL A 181
HIS A 183
 None
 0.83A 4pevC-1z2zA:
undetectable		 4pevC-1z2zA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		3 PRO A 265
VAL A 258
HIS A 257
 None
None
UMP  A 350 (-4.0A)
 0.76A 4pevC-2aazA:
undetectable		 4pevC-2aazA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2byo LIPOPROTEIN LPPX

(Mycobacterium
tuberculosis) 		PF07161
(LppX_LprAFG) 		3 PRO A  84
VAL A  62
HIS A  42
 OAA  A1218 (-4.4A)
None
ZN  A1213 ( 2.9A)
 0.84A 4pevC-2byoA:
undetectable		 4pevC-2byoA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cr6 KIAA1556 PROTEIN

(Homo sapiens) 		PF07679
(I-set) 		3 PRO A  39
VAL A  45
HIS A  46
 None
 0.84A 4pevC-2cr6A:
undetectable		 4pevC-2cr6A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 PRO A  20
VAL A  63
HIS A  62
 None
 0.78A 4pevC-2dphA:
3.1		 4pevC-2dphA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7j SEP-TRNA:CYS-TRNA
SYNTHASE

(Archaeoglobus
fulgidus) 		PF05889
(SepSecS) 		3 PRO A 192
VAL A 264
HIS A 263
 None
None
SO4  A 602 (-4.0A)
 0.76A 4pevC-2e7jA:
4.1		 4pevC-2e7jA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecr FLAVIN REDUCTASE
COMPONENT (HPAC) OF
4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		3 PRO A  57
VAL A  49
HIS A 116
 None
 0.75A 4pevC-2ecrA:
undetectable		 4pevC-2ecrA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eih ALCOHOL
DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 PRO A  21
VAL A  60
HIS A  59
 None
 0.76A 4pevC-2eihA:
4.1		 4pevC-2eihA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgy CARBOXYSOME SHELL
POLYPEPTIDE

(Halothiobacillus
neapolitanus) 		PF08936
(CsoSCA) 		3 PRO A 109
VAL A  93
HIS A  92
 None
None
ZN  A 621 (-3.3A)
 0.81A 4pevC-2fgyA:
2.4		 4pevC-2fgyA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		no annotation 3 PRO I 471
VAL I 464
HIS I 179
 None
 0.80A 4pevC-2gk1I:
undetectable		 4pevC-2gk1I:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B

(Homo sapiens) 		no annotation 3 PRO N 500
VAL N 493
HIS M 212
 None
 0.64A 4pevC-2gk1N:
undetectable		 4pevC-2gk1N:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gx8 NIF3-RELATED PROTEIN

(Bacillus cereus) 		PF01784
(NIF3) 		3 PRO A  39
VAL A 358
HIS A 359
 None
 0.80A 4pevC-2gx8A:
undetectable		 4pevC-2gx8A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hp3 IDS-EPIMERASE

(Agrobacterium
tumefaciens) 		PF03972
(MmgE_PrpD) 		3 PRO A 277
VAL A 382
HIS A 383
 None
 0.85A 4pevC-2hp3A:
undetectable		 4pevC-2hp3A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0n CLASS VII
UNCONVENTIONAL
MYOSIN

(Dictyostelium
discoideum) 		PF07653
(SH3_2) 		3 PRO A  73
VAL A  76
HIS A  77
 None
 0.78A 4pevC-2i0nA:
undetectable		 4pevC-2i0nA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 PRO A 558
VAL A 384
HIS A 385
 None
None
GOL  A 604 (-4.3A)
 0.73A 4pevC-2ihtA:
3.9		 4pevC-2ihtA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irw CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1

(Homo sapiens) 		PF00106
(adh_short) 		3 PRO A 178
VAL A 231
HIS A 232
 NN4  A 911 (-4.5A)
NN4  A 911 (-4.5A)
None
 0.73A 4pevC-2irwA:
5.6		 4pevC-2irwA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		3 PRO A 308
VAL A 367
HIS A 369
 None
 0.84A 4pevC-2obmA:
undetectable		 4pevC-2obmA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		3 PRO A 122
VAL A 215
HIS A 216
 None
 0.76A 4pevC-2oi6A:
2.2		 4pevC-2oi6A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		3 PRO A 136
VAL A 131
HIS A 216
 None
 0.81A 4pevC-2oi6A:
2.2		 4pevC-2oi6A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyw UNCHARACTERIZED
PROTEIN

(Arabidopsis
thaliana) 		PF01636
(APH) 		3 PRO A 137
VAL A 246
HIS A 123
 None
 0.67A 4pevC-2pywA:
undetectable		 4pevC-2pywA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		3 PRO A  84
VAL A 129
HIS A 131
 None
 0.69A 4pevC-2wdaA:
undetectable		 4pevC-2wdaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu8 PA1645

(Pseudomonas
aeruginosa) 		PF16985
(DUF5086) 		3 PRO A  28
VAL A  58
HIS A  78
 None
 0.84A 4pevC-2xu8A:
undetectable		 4pevC-2xu8A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9e MYOSIN-2

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 PRO X 713
VAL X 726
HIS X 729
 None
 0.71A 4pevC-2y9eX:
undetectable		 4pevC-2y9eX:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 PRO A 307
VAL A 331
HIS A 330
 None
 0.85A 4pevC-2yquA:
undetectable		 4pevC-2yquA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0f PUTATIVE
PHOSPHOGLUCOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 PRO A 488
VAL A 351
HIS A 355
 None
 0.82A 4pevC-2z0fA:
3.4		 4pevC-2z0fA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a05 TRYPTOPHANYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		3 PRO A 220
VAL A 214
HIS A 246
 None
 0.66A 4pevC-3a05A:
2.6		 4pevC-3a05A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2k TRNA(ILE)-LYSIDINE
SYNTHASE

(Geobacillus
kaustophilus) 		PF01171
(ATP_bind_3)
PF09179
(TilS)
PF11734
(TilS_C) 		3 PRO A 286
VAL A 291
HIS A 295
 None
C  C  26 ( 4.6A)
G  C  25 ( 4.5A)
 0.85A 4pevC-3a2kA:
2.5		 4pevC-3a2kA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		3 PRO A 350
VAL A 342
HIS A 341
 None
 0.61A 4pevC-3aivA:
undetectable		 4pevC-3aivA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bsx PUMILIO HOMOLOG 1

(Homo sapiens) 		PF00806
(PUF) 		3 PRO A1055
VAL A1049
HIS A1048
 None
 0.75A 4pevC-3bsxA:
undetectable		 4pevC-3bsxA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR

(Bordetella
pertussis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 PRO A  78
VAL A 130
HIS A 129
 None
 0.75A 4pevC-3efmA:
undetectable		 4pevC-3efmA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3err FUSION PROTEIN OF
MICROTUBULE BINDING
DOMAIN FROM MOUSE
CYTOPLASMIC DYNEIN
AND SERYL-TRNA
SYNTHETASE FROM
THERMUS THERMOPHILUS

(Mus musculus;
Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF12777
(MT) 		3 PRO A 410
VAL A 404
HIS A 395
 None
 0.79A 4pevC-3errA:
undetectable		 4pevC-3errA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fww BIFUNCTIONAL PROTEIN
GLMU

(Yersinia pestis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		3 PRO A 122
VAL A 215
HIS A 216
 None
 0.81A 4pevC-3fwwA:
2.6		 4pevC-3fwwA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fys PROTEIN DEGV

(Bacillus
subtilis) 		PF02645
(DegV) 		3 PRO A 141
VAL A   5
HIS A  24
 None
 0.82A 4pevC-3fysA:
2.6		 4pevC-3fysA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gym PROSTASIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 PRO A 225
VAL A 160
HIS A 135
 None
 0.82A 4pevC-3gymA:
undetectable		 4pevC-3gymA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwp PHLG

(Pseudomonas
protegens) 		no annotation 3 PRO A  63
VAL A 213
HIS A 214
 None
 0.71A 4pevC-3hwpA:
undetectable		 4pevC-3hwpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2m ORF59

(Human
gammaherpesvirus
8) 		PF04929
(Herpes_DNAp_acc) 		3 PRO X  68
VAL X  37
HIS X  38
 None
 0.81A 4pevC-3i2mX:
undetectable		 4pevC-3i2mX:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE

(Streptomyces
coelicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 PRO A  64
VAL A 120
HIS A 119
 None
 0.76A 4pevC-3krtA:
undetectable		 4pevC-3krtA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 PRO A  78
VAL A   6
HIS A   7
 None
 0.71A 4pevC-3kumA:
2.7		 4pevC-3kumA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Burkholderia
mallei) 		PF00551
(Formyl_trans_N) 		3 PRO A 185
VAL A 230
HIS A 228
 None
UNL  A 292 ( 4.3A)
None
 0.66A 4pevC-3louA:
6.1		 4pevC-3louA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9l HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Pseudomonas
protegens) 		PF13419
(HAD_2) 		3 PRO A  73
VAL A  21
HIS A  22
 None
 0.84A 4pevC-3m9lA:
4.0		 4pevC-3m9lA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pft FLAVIN REDUCTASE

(Mycolicibacterium
goodii) 		PF01613
(Flavin_Reduct) 		3 PRO A  63
VAL A  55
HIS A 130
 None
FMN  A 401 (-3.6A)
None
 0.81A 4pevC-3pftA:
undetectable		 4pevC-3pftA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8n 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		3 PRO A 425
VAL A 410
HIS A 405
 None
 0.82A 4pevC-3q8nA:
3.5		 4pevC-3q8nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t36 ENDO-TYPE
MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A

(Escherichia
coli) 		PF01464
(SLT) 		3 PRO A 187
VAL A 180
HIS A 179
 None
 0.82A 4pevC-3t36A:
undetectable		 4pevC-3t36A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		3 PRO A 242
VAL A 206
HIS A 205
 None
 0.65A 4pevC-3tqsA:
3.5		 4pevC-3tqsA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		3 PRO A 406
VAL A  93
HIS A  94
 None
 0.75A 4pevC-3w6qA:
undetectable		 4pevC-3w6qA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Thermus
thermophilus) 		PF00551
(Formyl_trans_N)
PF01842
(ACT) 		3 PRO A 179
VAL A 224
HIS A 222
 None
 0.80A 4pevC-3w7bA:
6.0		 4pevC-3w7bA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE

(Methanocaldococcus
jannaschii) 		PF05889
(SepSecS) 		3 PRO A 217
VAL A 289
HIS A 288
 None
 0.69A 4pevC-3wksA:
3.8		 4pevC-3wksA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsv L-LACTATE
DEHYDROGENASE

(Enterococcus
mundtii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 PRO A 195
VAL A 200
HIS A 204
 None
 0.75A 4pevC-3wsvA:
4.2		 4pevC-3wsvA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrh UBIQUITIN
THIOESTERASE ZRANB1

(Homo sapiens) 		PF02338
(OTU) 		3 PRO A 618
VAL A 561
HIS A 630
 None
 0.80A 4pevC-3zrhA:
undetectable		 4pevC-3zrhA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 PRO A 669
VAL A 481
HIS A 482
 None
None
CUO  A9002 (-3.4A)
 0.83A 4pevC-4bedA:
undetectable		 4pevC-4bedA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 PRO B3143
VAL B2964
HIS B2965
 None
None
CUO  B9008 (-3.2A)
 0.64A 4pevC-4bedB:
undetectable		 4pevC-4bedB:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		3 PRO A 344
VAL A 374
HIS A 453
 None
 0.83A 4pevC-4bqiA:
4.6		 4pevC-4bqiA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dj3 PERIOD CIRCADIAN
PROTEIN HOMOLOG 3

(Mus musculus) 		PF08447
(PAS_3) 		3 PRO A 225
VAL A 251
HIS A 124
 None
 0.83A 4pevC-4dj3A:
undetectable		 4pevC-4dj3A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fx5 VON WILLEBRAND
FACTOR TYPE A

(Catenulispora
acidiphila) 		PF13768
(VWA_3) 		3 PRO A 301
VAL A  24
HIS A  25
 None
 0.61A 4pevC-4fx5A:
3.1		 4pevC-4fx5A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0r CAPSID PROTEIN VP1

(Rodent
protoparvovirus
1) 		PF00740
(Parvo_coat) 		3 PRO A 545
VAL A 588
HIS A 286
 None
 0.80A 4pevC-4g0rA:
undetectable		 4pevC-4g0rA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2b SECRETED EFFECTOR
PROTEIN SSEI

(Salmonella
enterica) 		PF15645
(Tox-PLDMTX) 		3 PRO A 184
VAL A 232
HIS A 235
 None
 0.77A 4pevC-4g2bA:
undetectable		 4pevC-4g2bA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING

(Polaromonas sp.
JS666) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 PRO A 215
VAL A  82
HIS A 101
 None
 0.84A 4pevC-4g2nA:
6.6		 4pevC-4g2nA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfv UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		PF16848
(SoDot-IcmSS) 		3 PRO A  50
VAL A  44
HIS A  26
 None
None
CIT  A 301 (-3.6A)
 0.83A 4pevC-4hfvA:
undetectable		 4pevC-4hfvA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iws PA0254

(Pseudomonas
aeruginosa) 		PF01977
(UbiD) 		3 PRO A  47
VAL A  24
HIS A  25
 None
 0.84A 4pevC-4iwsA:
undetectable		 4pevC-4iwsA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5n URACIL-DNA
GLYCOSYLASE

(Human
alphaherpesvirus
1) 		PF03167
(UDG) 		3 PRO A  93
VAL A 152
HIS A 160
 None
 0.80A 4pevC-4l5nA:
2.9		 4pevC-4l5nA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcc BETA-2-MICROGLOBULIN
, MHC CLASS
I-RELATED PROTEIN

(Bos taurus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 PRO C 294
VAL C 371
HIS C 370
 None
 0.81A 4pevC-4lccC:
undetectable		 4pevC-4lccC:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lt6 POLY(A) POLYMERASE
GAMMA

(Homo sapiens) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		3 PRO A 497
VAL A 433
HIS A 386
 None
 0.82A 4pevC-4lt6A:
undetectable		 4pevC-4lt6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE

(Homo sapiens) 		PF00596
(Aldolase_II) 		3 PRO A 162
VAL A 197
HIS A 115
 None
None
ZN  A 301 (-3.3A)
 0.84A 4pevC-4m6rA:
undetectable		 4pevC-4m6rA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obs ALPHA-L-IDURONIDASE

(Homo sapiens) 		PF01229
(Glyco_hydro_39) 		3 PRO A 464
VAL A 540
HIS A 539
 None
 0.78A 4pevC-4obsA:
undetectable		 4pevC-4obsA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q52 UNCHARACTERIZED
PROTEIN

(Chitinophaga
pinensis) 		PF12306
(PixA) 		3 PRO A  81
VAL A  24
HIS A  25
 None
 0.78A 4pevC-4q52A:
undetectable		 4pevC-4q52A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qa8 PUTATIVE LIPOPROTEIN
LPRF

(Mycobacterium
bovis) 		PF07161
(LppX_LprAFG) 		3 PRO A 152
VAL A  77
HIS A  76
 PJZ  A 301 (-4.8A)
None
None
 0.77A 4pevC-4qa8A:
undetectable		 4pevC-4qa8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdj CAPSID

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		3 PRO A 445
VAL A 393
HIS A 334
 None
 0.57A 4pevC-4rdjA:
undetectable		 4pevC-4rdjA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzb CELA

(Geobacillus sp.
70PC53) 		PF00150
(Cellulase) 		3 PRO A 226
VAL A 202
HIS A 203
 None
 0.83A 4pevC-4xzbA:
undetectable		 4pevC-4xzbA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA

(Escherichia
coli) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		3 PRO D 329
VAL D 233
HIS D 178
 None
 0.80A 4pevC-4yg7D:
undetectable		 4pevC-4yg7D:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT ALPHA

(Yersinia
enterocolitica) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 PRO C 287
VAL C 548
HIS C 554
 None
 0.69A 4pevC-4z42C:
undetectable		 4pevC-4z42C:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpr HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA

(Mus musculus) 		PF00989
(PAS)
PF08447
(PAS_3) 		3 PRO B 228
VAL B 336
HIS B 246
 None
 0.84A 4pevC-4zprB:
undetectable		 4pevC-4zprB:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7a BARLEY STRIPE MOSAIC
VIRUS NARROW

(Barley stripe
mosaic virus) 		PF00721
(TMV_coat) 		3 PRO A 175
VAL A  36
HIS A  35
 None
 0.84A 4pevC-5a7aA:
undetectable		 4pevC-5a7aA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5v ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
brucei) 		PF00719
(Pyrophosphatase) 		3 PRO A 274
VAL A 313
HIS A 336
 None
 0.69A 4pevC-5c5vA:
undetectable		 4pevC-5c5vA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjj PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Campylobacter
jejuni) 		PF00551
(Formyl_trans_N) 		3 PRO A  99
VAL A 142
HIS A 140
 None
 0.74A 4pevC-5cjjA:
5.2		 4pevC-5cjjA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuv ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
cruzi) 		PF00719
(Pyrophosphatase) 		3 PRO A 274
VAL A 313
HIS A 336
 None
None
MLT  A 501 (-4.2A)
 0.61A 4pevC-5cuvA:
undetectable		 4pevC-5cuvA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cux ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
cruzi) 		PF00719
(Pyrophosphatase) 		3 PRO A 274
VAL A 313
HIS A 336
 None
None
POP  A 801 ( 4.8A)
 0.82A 4pevC-5cuxA:
undetectable		 4pevC-5cuxA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
brucei) 		PF00719
(Pyrophosphatase) 		3 PRO A 274
VAL A 313
HIS A 336
 None
None
CIT  A 901 (-3.8A)
 0.66A 4pevC-5cuyA:
undetectable		 4pevC-5cuyA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3b MACRODOMAIN PROTEIN

(Streptomyces
coelicolor) 		no annotation 3 PRO A  96
VAL A  25
HIS A  24
 None
 0.84A 4pevC-5e3bA:
3.7		 4pevC-5e3bA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3y UNCONVENTIONAL
MYOSIN-VIIB

(Mus musculus) 		PF00784
(MyTH4) 		3 PRO A1122
VAL A1157
HIS A1236
 None
 0.83A 4pevC-5f3yA:
undetectable		 4pevC-5f3yA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7u MAJOR CAPSID PROTEIN

(Faustovirus) 		PF04451
(Capsid_NCLDV) 		3 PRO A 180
VAL A 106
HIS A 105
 None
 0.66A 4pevC-5j7uA:
undetectable		 4pevC-5j7uA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kem EBOLA SECRETED
GLYCOPROTEIN

(Zaire
ebolavirus) 		PF01611
(Filo_glycop) 		3 PRO A 133
VAL A 138
HIS A 139
 None
 0.71A 4pevC-5kemA:
undetectable		 4pevC-5kemA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE

(Arabidopsis
thaliana) 		PF03254
(XG_FTase) 		3 PRO A 393
VAL A 443
HIS A 444
 None
 0.85A 4pevC-5kx6A:
2.5		 4pevC-5kx6A:
20.44