SIMILAR PATTERNS OF AMINO ACIDS FOR 4PEV_B_ADNB501_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)

(Thermococcus
kodakarensis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 PRO A 324
LEU A 325
GLN A 416
 None
 0.50A 4pevB-1b8aA:
undetectable		 4pevB-1b8aA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Homo sapiens) 		PF00490
(ALAD) 		3 PRO A  67
LEU A  68
GLN A 325
 None
 0.60A 4pevB-1e51A:
undetectable		 4pevB-1e51A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eo8 ANTIBODY (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H  16
LEU H  82
GLN H  81
 None
 0.72A 4pevB-1eo8H:
undetectable		 4pevB-1eo8H:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fux HYPOTHETICAL 19.5
KDA PROTEIN IN
EMRE-RUS INTERGENIC
REGION

(Escherichia
coli) 		PF01161
(PBP) 		3 PRO A  77
LEU A  76
GLN A  94
 None
 0.69A 4pevB-1fuxA:
undetectable		 4pevB-1fuxA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7j PROTEIN YCIO

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC) 		3 PRO A  60
LEU A  59
GLN A 113
 None
 0.54A 4pevB-1k7jA:
undetectable		 4pevB-1k7jA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8c CREB-BINDING PROTEIN

(Mus musculus) 		PF02135
(zf-TAZ) 		3 PRO A  38
LEU A  37
GLN A  11
 None
 0.70A 4pevB-1l8cA:
undetectable		 4pevB-1l8cA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF02548
(Pantoate_transf) 		3 PRO A  86
LEU A  85
GLN A  95
 None
 0.67A 4pevB-1m3uA:
undetectable		 4pevB-1m3uA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Geobacillus
stearothermophilus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 PRO A 498
LEU A 497
GLN A 323
 None
 0.56A 4pevB-1o99A:
4.2		 4pevB-1o99A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 PRO A 110
LEU A 109
GLN A 117
 None
 0.70A 4pevB-1qorA:
3.3		 4pevB-1qorA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ECDYSONE RECEPTOR

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		3 PRO D 519
LEU D 522
GLN D 348
 None
 0.71A 4pevB-1r20D:
undetectable		 4pevB-1r20D:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryn PROTEIN CRS2

(Zea mays) 		PF01195
(Pept_tRNA_hydro) 		3 PRO A  99
LEU A  98
GLN A 192
 PRO  A  99 ( 1.1A)
LEU  A  98 ( 0.5A)
GLN  A 192 ( 0.6A)
 0.53A 4pevB-1rynA:
5.0		 4pevB-1rynA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp4 UV EXCISION REPAIR
PROTEIN RAD23
HOMOLOG A

(Homo sapiens) 		PF09280
(XPC-binding) 		3 PRO A 231
LEU A 232
GLN A 240
 None
 0.52A 4pevB-1tp4A:
undetectable		 4pevB-1tp4A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0k GENE PRODUCT PA4716

(Pseudomonas
aeruginosa) 		PF02567
(PhzC-PhzF) 		3 PRO A  15
LEU A  16
GLN A   7
 None
 0.73A 4pevB-1u0kA:
undetectable		 4pevB-1u0kA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, ALPHA
SUBUNIT
PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 PRO A 139
LEU A 138
GLN B  96
 None
 0.73A 4pevB-1w85A:
2.5		 4pevB-1w85A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsa BIS(5'-NUCLEOSYL)-TE
TRAPHOSPHATASE

(Homo sapiens) 		PF00293
(NUDIX) 		3 PRO A  45
LEU A  33
GLN A 132
 None
 0.70A 4pevB-1xsaA:
undetectable		 4pevB-1xsaA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		3 PRO A 313
LEU A 312
GLN A 465
 None
 0.62A 4pevB-1yiqA:
undetectable		 4pevB-1yiqA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		PF01082
(Cu2_monooxygen)
PF03712
(Cu2_monoox_C) 		3 PRO A 151
LEU A 150
GLN A 198
 None
GOL  A 701 (-4.5A)
GOL  A 704 (-3.6A)
 0.61A 4pevB-1yjkA:
undetectable		 4pevB-1yjkA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5x ECDYSONE RECEPTOR
LIGAND BINDING
DOMAIN

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		3 PRO E 405
LEU E 408
GLN E 236
 None
 0.52A 4pevB-1z5xE:
undetectable		 4pevB-1z5xE:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		3 PRO A 194
LEU A 169
GLN A 158
 None
 0.71A 4pevB-2bp1A:
undetectable		 4pevB-2bp1A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2diw PUTATIVE RNA-BINDING
PROTEIN 16

(Homo sapiens) 		PF04818
(CTD_bind) 		3 PRO A 139
LEU A 140
GLN A 106
 None
 0.48A 4pevB-2diwA:
undetectable		 4pevB-2diwA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1) 		PF01499
(Herpes_UL25) 		3 PRO A 327
LEU A 326
GLN A 372
 None
 0.65A 4pevB-2f5uA:
undetectable		 4pevB-2f5uA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lwx ZUOTIN

(Saccharomyces
cerevisiae) 		PF16717
(RAC_head) 		3 PRO A 425
LEU A 424
GLN A 380
 None
 0.44A 4pevB-2lwxA:
undetectable		 4pevB-2lwxA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 PRO A 700
LEU A 701
GLN A 708
 None
 0.38A 4pevB-2nq5A:
3.4		 4pevB-2nq5A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE

(Rattus
norvegicus) 		PF00171
(Aldedh) 		3 PRO A 627
LEU A 626
GLN A 457
 None
 0.71A 4pevB-2o2qA:
2.3		 4pevB-2o2qA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oca ATP-DEPENDENT DNA
HELICASE UVSW

(Escherichia
virus T4) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		3 PRO A  61
LEU A  60
GLN A  67
 None
 0.70A 4pevB-2ocaA:
2.7		 4pevB-2ocaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		3 PRO A 282
LEU A 281
GLN A 336
 FAD  A 500 (-4.5A)
None
None
 0.72A 4pevB-2qa2A:
undetectable		 4pevB-2qa2A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 PRO A 223
LEU A 224
GLN A 204
 None
 0.63A 4pevB-2qdeA:
2.3		 4pevB-2qdeA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkw CARBOXYLESTERASE

(Alcaligenes sp.) 		no annotation 3 PRO A 212
LEU A 190
GLN A 104
 None
 0.69A 4pevB-2wkwA:
3.6		 4pevB-2wkwA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgv PSIV CAPSID
N-TERMINAL DOMAIN

(Microcebus
murinus) 		PF00607
(Gag_p24) 		3 PRO A   1
LEU A  47
GLN A  54
 None
 0.57A 4pevB-2xgvA:
undetectable		 4pevB-2xgvA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		3 PRO A 170
LEU A 171
GLN A 117
 None
 0.50A 4pevB-2xydA:
undetectable		 4pevB-2xydA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuc DNA REPAIR AND
RECOMBINATION
PROTEIN RADA

(Sulfolobus
solfataricus) 		PF08423
(Rad51)
PF14520
(HHH_5) 		3 PRO A 281
LEU A 237
GLN A 230
 None
 0.62A 4pevB-2zucA:
3.6		 4pevB-2zucA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1d REGULATORY PROTEIN
RECX

(Escherichia
coli) 		PF02631
(RecX) 		3 PRO A 134
LEU A 133
GLN A 144
 None
 0.58A 4pevB-3c1dA:
undetectable		 4pevB-3c1dA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		3 PRO A  99
LEU A  98
GLN A  76
 None
 0.68A 4pevB-3ciyA:
undetectable		 4pevB-3ciyA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PRO A 171
LEU A 230
GLN A 154
 None
 0.65A 4pevB-3dkhA:
undetectable		 4pevB-3dkhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evt PHOSPHOGLYCERATE
DEHYDROGENASE

(Lactobacillus
plantarum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 PRO A 260
LEU A 259
GLN A 267
 None
 0.56A 4pevB-3evtA:
2.1		 4pevB-3evtA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Nocardioides
aromaticivorans) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		3 PRO A 156
LEU A 155
GLN A 136
 None
 0.73A 4pevB-3gcfA:
undetectable		 4pevB-3gcfA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 PRO A  41
LEU A  67
GLN A 368
 None
 0.69A 4pevB-3h9uA:
5.1		 4pevB-3h9uA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4

(Thermus
thermophilus) 		PF00346
(Complex1_49kDa) 		3 PRO 4 337
LEU 4 105
GLN 4 308
 None
 0.71A 4pevB-3i9v4:
undetectable		 4pevB-3i9v4:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq1 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 PRO A 237
LEU A 238
GLN A 211
 None
None
CA  A   5 (-3.2A)
 0.71A 4pevB-3jq1A:
undetectable		 4pevB-3jq1A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mog PROBABLE
3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Escherichia
coli) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 PRO A 230
LEU A 231
GLN A 265
 None
 0.67A 4pevB-3mogA:
4.5		 4pevB-3mogA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Kosmotoga
olearia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 PRO A 237
LEU A 238
GLN A 219
 None
 0.68A 4pevB-3mwcA:
3.1		 4pevB-3mwcA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 PRO A  44
LEU A  70
GLN A 403
 None
 0.71A 4pevB-3n58A:
3.4		 4pevB-3n58A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt1 UPF0364 PROTEIN
YMR027W

(Saccharomyces
cerevisiae) 		PF01937
(DUF89) 		3 PRO A 408
LEU A 409
GLN A 374
 None
 0.60A 4pevB-3pt1A:
3.1		 4pevB-3pt1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4r PHOSPHOPROTEIN

(Lettuce
necrotic
yellows
cytorhabdovirus) 		no annotation 3 PRO A  48
LEU A  46
GLN A  55
 None
 0.68A 4pevB-3t4rA:
undetectable		 4pevB-3t4rA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uoe DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02615
(Ldh_2) 		3 PRO A  50
LEU A  53
GLN A  29
 None
 0.63A 4pevB-3uoeA:
undetectable		 4pevB-3uoeA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v6a APOPTOSIS INHIBITOR
5

(Homo sapiens) 		PF05918
(API5) 		3 PRO A 247
LEU A 248
GLN A 205
 None
 0.71A 4pevB-3v6aA:
undetectable		 4pevB-3v6aA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		3 PRO A 565
LEU A 564
GLN A  34
 None
 0.64A 4pevB-3w9hA:
undetectable		 4pevB-3w9hA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		3 PRO A 565
LEU A 564
GLN A  34
 None
 0.59A 4pevB-3w9iA:
undetectable		 4pevB-3w9iA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1

(Candida
parapsilosis) 		PF00248
(Aldo_ket_red) 		3 PRO A 224
LEU A 225
GLN A 283
 None
 0.49A 4pevB-3wg6A:
undetectable		 4pevB-3wg6A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5o BIFUNCTIONAL PROTEIN
FOLD

(Pseudomonas
aeruginosa) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		3 PRO A 102
LEU A 101
GLN A  76
 None
 0.65A 4pevB-4a5oA:
4.4		 4pevB-4a5oA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq7 MEMBRANE PROTEIN
PHI6 P5

(Pseudomonas
virus phi6) 		PF10464
(Peptidase_U40) 		3 PRO A  53
LEU A  52
GLN A 199
 None
 0.70A 4pevB-4dq7A:
undetectable		 4pevB-4dq7A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ebj AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE

(Pseudomonas
aeruginosa) 		PF01909
(NTP_transf_2) 		3 PRO A  92
LEU A  91
GLN A 176
 None
 0.70A 4pevB-4ebjA:
undetectable		 4pevB-4ebjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		3 PRO A  25
LEU A  26
GLN A  33
 None
 0.69A 4pevB-4efcA:
undetectable		 4pevB-4efcA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		3 PRO A 238
LEU A 237
GLN A 252
 None
 0.71A 4pevB-4ez5A:
undetectable		 4pevB-4ez5A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7g TALIN-1

(Mus musculus) 		PF00373
(FERM_M)
PF02174
(IRS) 		3 PRO A 267
LEU A 266
GLN A 273
 None
 0.70A 4pevB-4f7gA:
undetectable		 4pevB-4f7gA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		3 PRO A 283
LEU A 282
GLN A 289
 PRO  A 283 ( 1.1A)
LEU  A 282 ( 0.6A)
GLN  A 289 ( 0.6A)
 0.58A 4pevB-4hneA:
undetectable		 4pevB-4hneA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE

(Streptomyces
atroolivaceus) 		no annotation 3 PRO A 167
LEU A 166
GLN A  96
 None
 0.63A 4pevB-4hzpA:
undetectable		 4pevB-4hzpA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		3 PRO A 491
LEU A 490
GLN A 495
 None
 0.65A 4pevB-4ipeA:
undetectable		 4pevB-4ipeA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwb FLIC, FLIS CHIMERA

(Aquifex
aeolicus) 		PF00700
(Flagellin_C)
PF02561
(FliS) 		3 PRO A  58
LEU A  59
GLN A  30
 None
 0.69A 4pevB-4iwbA:
undetectable		 4pevB-4iwbA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 3 PRO A 440
LEU A 444
GLN A 391
 None
 0.72A 4pevB-4jzaA:
undetectable		 4pevB-4jzaA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus) 		PF01494
(FAD_binding_3) 		3 PRO A  84
LEU A  83
GLN A 303
 None
 0.50A 4pevB-4k5rA:
2.1		 4pevB-4k5rA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		3 PRO A 842
LEU A 843
GLN A 904
 None
 0.68A 4pevB-4lglA:
6.5		 4pevB-4lglA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 PRO A  47
LEU A  73
GLN A 408
 None
 0.73A 4pevB-4lvcA:
5.4		 4pevB-4lvcA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4of7 PROTEIN SYG-1,
ISOFORM B

(Caenorhabditis
elegans) 		PF07679
(I-set) 		3 PRO A  71
LEU A  70
GLN A  54
 None
 0.71A 4pevB-4of7A:
undetectable		 4pevB-4of7A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt ECDYSONE RECEPTOR

(Pediculus
humanus) 		PF00104
(Hormone_recep) 		3 PRO E 509
LEU E 512
GLN E 340
 None
 0.73A 4pevB-4oztE:
undetectable		 4pevB-4oztE:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puc SUSD HOMOLOG

(Bacteroides
uniformis) 		PF12741
(SusD-like) 		3 PRO A 270
LEU A 271
GLN A  66
 None
 0.70A 4pevB-4pucA:
undetectable		 4pevB-4pucA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2v CYSTEINE SYNTHETASE

(Helicobacter
pylori) 		PF00291
(PALP) 		3 PRO A 283
LEU A 282
GLN A 287
 None
 0.64A 4pevB-4r2vA:
2.5		 4pevB-4r2vA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		3 PRO A 226
LEU A 180
GLN A 312
 None
 0.67A 4pevB-4rbnA:
4.4		 4pevB-4rbnA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		3 PRO A 249
LEU A 250
GLN A 174
 None
 0.60A 4pevB-4uvkA:
undetectable		 4pevB-4uvkA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3i VCA0115

(Vibrio cholerae) 		PF09850
(DotU) 		3 PRO A  45
LEU A  46
GLN A  68
 None
 0.59A 4pevB-4v3iA:
undetectable		 4pevB-4v3iA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 PRO A 507
LEU A 506
GLN A 514
 None
 0.66A 4pevB-4wz9A:
undetectable		 4pevB-4wz9A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 PROTEIN ATS1

(Saccharomyces
cerevisiae) 		PF00415
(RCC1) 		3 PRO B 209
LEU B 208
GLN B 217
 None
 0.62A 4pevB-4x33B:
undetectable		 4pevB-4x33B:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00659
(POLO_box) 		3 PRO A 590
LEU A 589
GLN A 502
 None
 0.71A 4pevB-4xb0A:
undetectable		 4pevB-4xb0A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybh ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Homo sapiens) 		PF00047
(ig)
PF08205
(C2-set_2)
PF13895
(Ig_2) 		3 PRO A 289
LEU A 288
GLN A 294
 None
 0.63A 4pevB-4ybhA:
undetectable		 4pevB-4ybhA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 PRO A 445
LEU A 739
GLN A 482
 None
 0.69A 4pevB-4ztxA:
2.0		 4pevB-4ztxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1r 7S VICILIN

(Carya
illinoinensis) 		PF00190
(Cupin_1) 		3 PRO A 431
LEU A 430
GLN A 543
 None
 0.66A 4pevB-5e1rA:
undetectable		 4pevB-5e1rA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 PRO A 677
LEU A 676
GLN A 680
 None
 0.60A 4pevB-5f7cA:
undetectable		 4pevB-5f7cA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		3 PRO A  41
LEU A  42
GLN A  51
 None
 0.46A 4pevB-5karA:
undetectable		 4pevB-5karA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0t ALPHA-KETOGLUTARATE-
DEPENDENT NON-HEME
IRON OXYGENASE EASH

(Aspergillus
japonicus) 		PF05721
(PhyH) 		3 PRO A 243
LEU A 242
GLN A 255
 None
 0.71A 4pevB-5m0tA:
undetectable		 4pevB-5m0tA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpi GRAINYHEAD-LIKE
PROTEIN 1 HOMOLOG

(Homo sapiens) 		no annotation 3 PRO A 392
LEU A 391
GLN A 317
 None
 0.61A 4pevB-5mpiA:
undetectable		 4pevB-5mpiA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr7 GRAINYHEAD-LIKE
PROTEIN 2 HOMOLOG

(Homo sapiens) 		no annotation 3 PRO A 388
LEU A 387
GLN A 313
 None
 0.65A 4pevB-5mr7A:
undetectable		 4pevB-5mr7A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 3 PRO A  45
LEU A  44
GLN A  29
 None
 0.68A 4pevB-5n7qA:
undetectable		 4pevB-5n7qA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		3 PRO A  61
LEU A  60
GLN A 167
 None
 0.57A 4pevB-5n8oA:
undetectable		 4pevB-5n8oA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2

(Homo sapiens) 		no annotation 3 PRO A 645
LEU A 644
GLN A 636
 None
 0.52A 4pevB-5o0yA:
undetectable		 4pevB-5o0yA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqp CONDENSIN COMPLEX
SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 3 PRO A 459
LEU A 460
GLN A 424
 None
 0.59A 4pevB-5oqpA:
undetectable		 4pevB-5oqpA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szw ELAV-LIKE PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1) 		3 PRO A  30
LEU A  29
GLN A  35
 None
 0.58A 4pevB-5szwA:
undetectable		 4pevB-5szwA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE

(Bacillus
subtilis) 		PF04055
(Radical_SAM)
PF13394
(Fer4_14) 		3 PRO A 230
LEU A 229
GLN A  16
 None
None
7C5  A 302 (-3.5A)
 0.60A 4pevB-5th5A:
undetectable		 4pevB-5th5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tse LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Acinetobacter
baumannii) 		no annotation 3 PRO A 165
LEU A 164
GLN A 105
 None
 0.64A 4pevB-5tseA:
undetectable		 4pevB-5tseA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio;
Streptococcus
pyogenes) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		3 PRO A 491
LEU A 490
GLN A 495
 None
 0.67A 4pevB-5tthA:
undetectable		 4pevB-5tthA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		3 PRO A1625
LEU A1624
GLN A1435
 None
 0.54A 4pevB-5u1sA:
2.8		 4pevB-5u1sA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v33 REACTION CENTER
PROTEIN H CHAIN

(Rhodobacter
sphaeroides) 		PF03967
(PRCH)
PF05239
(PRC) 		3 PRO H 152
LEU H 151
GLN H 199
 None
 0.69A 4pevB-5v33H:
undetectable		 4pevB-5v33H:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		no annotation 3 PRO A 151
LEU A 150
GLN A 198
 None
 0.63A 4pevB-5wm0A:
undetectable		 4pevB-5wm0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1i CYTOCHROME P450

(Streptomyces
graminofaciens) 		PF00067
(p450) 		3 PRO A  43
LEU A  44
GLN A  64
 None
 0.44A 4pevB-5y1iA:
undetectable		 4pevB-5y1iA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 3 PRO B 327
LEU B 326
GLN B 333
 None
 0.73A 4pevB-5y58B:
3.1		 4pevB-5y58B:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh0 DRFAM20C1

(Danio rerio) 		no annotation 3 PRO A 143
LEU A 144
GLN A 553
 None
 0.73A 4pevB-5yh0A:
undetectable		 4pevB-5yh0A:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5k NETRIN RECEPTOR DCC

(Rattus
norvegicus) 		no annotation 3 PRO A 193
LEU A 192
GLN A 244
 None
 0.71A 4pevB-5z5kA:
undetectable		 4pevB-5z5kA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d14 TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		no annotation 3 PRO A 491
LEU A 490
GLN A 495
 None
 0.64A 4pevB-6d14A:
undetectable		 4pevB-6d14A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 3 PRO A 354
LEU A 353
GLN A   6
 None
 0.66A 4pevB-6fikA:
undetectable		 4pevB-6fikA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fra HUMAN T-CELL
RECEPTOR F11 ALPHA
CHAIN

(Homo sapiens) 		no annotation 3 PRO A 112
LEU A 111
GLN A 143
 None
EDO  A 305 (-4.0A)
None
 0.60A 4pevB-6fraA:
undetectable		 4pevB-6fraA:
11.76