SIMILAR PATTERNS OF AMINO ACIDS FOR 4PEV_B_ADNB501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 GLY A 549
ASP A 548
PHE A 739
GLY A 742
ASP A 545
 None
 1.00A 4pevB-1b0kA:
0.0		 4pevB-1b0kA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1enf ENTEROTOXIN H

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 VAL A 114
ASN A 210
GLY A 118
ASP A 117
GLY A 162
 None
 1.41A 4pevB-1enfA:
0.0		 4pevB-1enfA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq8 PECTINESTERASE

(Daucus carota) 		PF01095
(Pectinesterase) 		5 VAL A 234
SER A 300
PHE A 301
GLY A 198
GLY A 295
 None
 1.17A 4pevB-1gq8A:
0.0		 4pevB-1gq8A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1o CYTOCHROME C-552

(Acidithiobacillus
ferrooxidans) 		PF00034
(Cytochrom_C) 		5 ASP A 126
PHE A 107
ASN A 108
GLY A 127
GLY A 103
 None
 0.97A 4pevB-1h1oA:
0.0		 4pevB-1h1oA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 VAL A 183
GLY A 186
PHE A 244
GLY A 273
ASP A 275
 None
None
None
None
HPA  A 599 (-2.8A)
 1.39A 4pevB-1jftA:
19.0		 4pevB-1jftA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		5 VAL A 183
GLY A 186
PHE A 244
GLY A 273
ASP A 275
 None
 1.36A 4pevB-1jhzA:
15.0		 4pevB-1jhzA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7s CATALASE

(Pseudomonas
syringae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ASP A 215
ASN A 217
PHE A 138
PHE A 134
GLY A 149
 None
None
None
None
HEM  A 600 (-4.0A)
 1.24A 4pevB-1m7sA:
0.0		 4pevB-1m7sA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy0 KETOPANTOATE
HYDROXYMETHYLTRANSFE
RASE

(Mycobacterium
tuberculosis) 		PF02548
(Pantoate_transf) 		5 VAL A  60
SER A  78
GLY A 125
ASP A 124
ASP A  80
 None
 1.33A 4pevB-1oy0A:
1.8		 4pevB-1oy0A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (GH-LOOP
FROM VIRUS CAPSID
PROTEIN VP1)
PROTEIN
(IMMUNOGLOBULIN
HEAVY CHAIN)

(Foot-and-mouth
disease virus;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		5 VAL A  97
ASP 5 143
PHE A 107
GLY A 106
ASP A 104
 None
 1.03A 4pevB-1qgcA:
undetectable		 4pevB-1qgcA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvz YDR533C PROTEIN

(Saccharomyces
cerevisiae) 		PF01965
(DJ-1_PfpI) 		5 VAL A 190
GLY A 146
PHE A 102
PHE A 144
GLY A 140
 None
None
None
None
CSO  A 138 ( 4.4A)
 1.32A 4pevB-1qvzA:
3.1		 4pevB-1qvzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tyj CELLULOSOMAL
SCAFFOLDIN

(Pseudobacteroides
cellulosolvens) 		PF00963
(Cohesin) 		5 ASN A  88
GLY A 144
PHE A 148
PHE A  36
GLY A  90
 None
 1.34A 4pevB-1tyjA:
undetectable		 4pevB-1tyjA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydw AX110P-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01408
(GFO_IDH_MocA) 		5 ASP A 127
VAL A 104
GLY A 128
PHE A 160
GLY A 186
 None
 1.40A 4pevB-1ydwA:
6.4		 4pevB-1ydwA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yns E-1 ENZYME

(Homo sapiens) 		no annotation 5 ASP A 212
VAL A 213
SER A 154
GLY A  19
PHE A  32
 MG  A1258 (-2.6A)
None
HPO  A1261 (-2.3A)
MG  A1258 ( 4.4A)
HPO  A1261 (-4.6A)
 1.24A 4pevB-1ynsA:
4.2		 4pevB-1ynsA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3q THAUMATIN-LIKE
PROTEIN

(Musa acuminata) 		PF00314
(Thaumatin) 		5 ASP A  96
SER A 110
PHE A 186
GLY A 118
ASP A 108
 EDO  A 902 ( 4.3A)
None
None
None
None
 1.28A 4pevB-1z3qA:
undetectable		 4pevB-1z3qA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1t ACYL TRANSFERASE

(Chrysanthemum x
morifolium) 		PF02458
(Transferase) 		5 ASP A  33
GLY A 318
PHE A  32
GLY A 322
ASP A 303
 None
None
None
None
MLC  A1001 (-4.8A)
 1.36A 4pevB-2e1tA:
undetectable		 4pevB-2e1tA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2enx MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Streptococcus
agalactiae) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 VAL A  21
SER A 120
GLY A   8
GLY A 147
ASP A 151
 None
None
None
None
MN  A 402 ( 2.7A)
 1.34A 4pevB-2enxA:
undetectable		 4pevB-2enxA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fdr CONSERVED
HYPOTHETICAL PROTEIN

(Agrobacterium
fabrum) 		PF13419
(HAD_2) 		5 GLY A  91
ASP A  90
PHE A 186
GLY A  13
ASP A  17
 None
None
None
MG  A1001 ( 4.6A)
None
 1.12A 4pevB-2fdrA:
3.5		 4pevB-2fdrA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		7 ASP A  27
SER A  35
ASN A  37
ASP A 108
PHE A 161
PHE A 186
GLY A 212
 GMP  A 400 (-2.9A)
GMP  A 400 ( 4.6A)
GMP  A 400 (-3.3A)
GMP  A 400 (-3.3A)
GMP  A 400 ( 4.8A)
GMP  A 400 (-3.4A)
GMP  A 400 (-3.3A)
 0.93A 4pevB-2fqxA:
39.7		 4pevB-2fqxA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		5 ASP A 263
VAL A 264
ASP A 238
PHE A 161
ASP A 108
 None
None
GMP  A 400 (-2.9A)
GMP  A 400 ( 4.8A)
GMP  A 400 (-3.3A)
 1.22A 4pevB-2fqxA:
39.7		 4pevB-2fqxA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		10 SER A  35
PHE A  36
ASN A  37
GLY A  85
ASP A 108
PHE A 161
PHE A 186
GLY A 212
ASP A 238
LYS A 260
 GMP  A 400 ( 4.6A)
GMP  A 400 (-3.8A)
GMP  A 400 (-3.3A)
GMP  A 400 ( 3.7A)
GMP  A 400 (-3.3A)
GMP  A 400 ( 4.8A)
GMP  A 400 (-3.4A)
GMP  A 400 (-3.3A)
GMP  A 400 (-2.9A)
GMP  A 400 (-2.8A)
 0.84A 4pevB-2fqxA:
39.7		 4pevB-2fqxA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpt EH DOMAIN-CONTAINING
PROTEIN-2

(Mus musculus) 		PF00350
(Dynamin_N)
PF12763
(EF-hand_4)
PF16880
(EHD_N) 		5 VAL A 217
SER A  73
GLY A 255
ASP A 222
GLY A  70
 None
ANP  A 600 (-2.6A)
None
ANP  A 600 ( 4.6A)
ANP  A 600 (-3.0A)
 1.37A 4pevB-2qptA:
3.9		 4pevB-2qptA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qts ACID-SENSING ION
CHANNEL

(Gallus gallus) 		PF00858
(ASC) 		5 ASP A 108
VAL A 104
PHE A 189
PHE A  99
GLY A 163
 None
 1.39A 4pevB-2qtsA:
undetectable		 4pevB-2qtsA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Paraburkholderia
phymatum) 		PF13377
(Peripla_BP_3) 		5 VAL A 210
GLY A 213
PHE A 271
GLY A 300
ASP A 302
 None
 1.41A 4pevB-2rgyA:
18.4		 4pevB-2rgyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v95 CORTICOSTEROID-BINDI
NG GLOBULIN

(Rattus
norvegicus) 		PF00079
(Serpin) 		5 VAL A 144
SER A 157
PHE A 156
ASN A 141
ASP A 160
 None
 1.38A 4pevB-2v95A:
undetectable		 4pevB-2v95A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 ASP G 442
VAL G 242
GLY G 441
PHE G  90
GLY G 184
 FAD  G 484 (-3.1A)
None
FAD  G 484 (-3.4A)
None
FAD  G 484 (-3.4A)
 1.42A 4pevB-2vdcG:
5.4		 4pevB-2vdcG:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 VAL A 384
SER A 396
ASN A 382
GLY A 144
LYS A 399
 None
 1.38A 4pevB-2y3sA:
undetectable		 4pevB-2y3sA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1

(Saccharomyces
cerevisiae) 		PF12697
(Abhydrolase_6) 		5 ASP A  93
SER A  61
GLY A  98
PHE A 224
GLY A  60
 None
 1.11A 4pevB-2y6vA:
4.6		 4pevB-2y6vA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A

(Homo sapiens) 		PF02373
(JmjC) 		5 ASP A 260
SER A 252
GLY A 259
PHE A  38
GLY A 254
 None
 1.04A 4pevB-2yu1A:
undetectable		 4pevB-2yu1A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 VAL A  60
PHE A 228
GLY A  53
GLY A  72
ASP A  76
 None
 1.32A 4pevB-2zxhA:
3.8		 4pevB-2zxhA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt6 INFLUENZA B
HEMAGGLUTININ (HA)

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		5 VAL A 279
GLY B  68
GLY A 275
ASP A 183
LYS A 251
 None
 1.41A 4pevB-3bt6A:
undetectable		 4pevB-3bt6A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3k ALANINE RACEMASE

(Actinobacillus
succinogenes) 		PF13377
(Peripla_BP_3) 		5 VAL A 247
GLY A  67
ASP A  66
GLY A  38
LYS A   7
 None
 1.38A 4pevB-3c3kA:
19.4		 4pevB-3c3kA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdo UNCHARACTERIZED
OXIDOREDUCTASE YVAA

(Bacillus
subtilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 VAL A 208
GLY A 181
ASP A 185
PHE A 221
GLY A 237
 None
 1.34A 4pevB-3gdoA:
3.0		 4pevB-3gdoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdo UNCHARACTERIZED
OXIDOREDUCTASE YVAA

(Bacillus
subtilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 VAL A 208
SER A 238
ASP A 185
PHE A 221
GLY A 237
 None
 1.41A 4pevB-3gdoA:
3.0		 4pevB-3gdoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hp7 HEMOLYSIN, PUTATIVE

(Streptococcus
thermophilus) 		PF01479
(S4)
PF01728
(FtsJ) 		5 ASP A 112
SER A  64
GLY A  90
ASP A 155
LYS A  69
 EOH  A 301 (-4.0A)
None
EOH  A 301 ( 3.7A)
None
None
 1.11A 4pevB-3hp7A:
undetectable		 4pevB-3hp7A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0h PHIKZ029

(Pseudomonas
virus phiKZ) 		no annotation 5 SER A 105
ASN A 103
GLY A 381
ASP A 380
GLY A 377
 None
 1.14A 4pevB-3j0hA:
undetectable		 4pevB-3j0hA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF16113
(ECH_2) 		5 VAL A 131
SER A  73
GLY A  81
PHE A  78
GLY A  72
 None
 1.37A 4pevB-3ju1A:
3.6		 4pevB-3ju1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4y ISOPENTENYL
PHOSPHATE KINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase) 		5 ASP A 180
VAL A 181
GLY A   9
GLY A 217
ASP A 160
 None
None
SO4  A 262 (-3.2A)
None
SO4  A 262 ( 4.4A)
 1.16A 4pevB-3k4yA:
4.9		 4pevB-3k4yA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		5 ASP A  42
SER A  65
ASN A 210
GLY A  45
GLY A 208
 None
 1.28A 4pevB-3kl9A:
3.2		 4pevB-3kl9A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lad DIHYDROLIPOAMIDE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 SER A  56
GLY A 172
ASP A 175
GLY A  52
LYS A  94
 FAD  A 480 (-3.3A)
None
None
FAD  A 480 (-3.3A)
None
 1.30A 4pevB-3ladA:
undetectable		 4pevB-3ladA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES

(Arabidopsis
thaliana) 		PF01048
(PNP_UDP_1) 		5 ASP A 200
SER A 134
GLY A 203
GLY A 173
ASP A 135
 SAH  A 268 ( 4.9A)
None
None
None
None
 1.33A 4pevB-3lgsA:
5.4		 4pevB-3lgsA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnd THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE

(Salmonella
enterica) 		PF02424
(ApbE) 		5 VAL A 285
GLY A 265
ASP A 264
PHE A 333
GLY A 332
 None
 1.27A 4pevB-3pndA:
undetectable		 4pevB-3pndA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pu5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Bordetella
parapertussis) 		PF13416
(SBP_bac_8) 		5 VAL A 140
GLY A 242
PHE A  44
GLY A 268
ASP A 136
 VAL  A 140 ( 0.6A)
GLY  A 242 ( 0.0A)
PHE  A  44 ( 1.3A)
GLY  A 268 ( 0.0A)
ASP  A 136 ( 0.6A)
 1.19A 4pevB-3pu5A:
3.1		 4pevB-3pu5A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS

(Aspergillus
oryzae) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 VAL A 504
SER A 470
GLY A 310
ASP A 423
GLY A 466
 None
 1.20A 4pevB-3q9tA:
undetectable		 4pevB-3q9tA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 ASP A 497
VAL A 374
SER A 474
GLY A 382
PHE A 423
 None
 1.36A 4pevB-3u1kA:
undetectable		 4pevB-3u1kA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uor ABC TRANSPORTER
SUGAR BINDING
PROTEIN

(Xanthomonas
citri) 		PF13416
(SBP_bac_8) 		5 VAL A 123
SER A 197
GLY A 300
ASP A 141
GLY A 296
 None
 1.31A 4pevB-3uorA:
2.5		 4pevB-3uorA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo0 E3 UBIQUITIN-PROTEIN
LIGASE TRIM21

(Mus musculus) 		PF00622
(SPRY)
PF13765
(PRY) 		5 VAL B 169
SER B 174
GLY B  34
ASP B  35
GLY B 176
 None
 1.21A 4pevB-3zo0B:
undetectable		 4pevB-3zo0B:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 VAL A 294
GLY A  57
PHE A 343
GLY A 342
ASP A 330
 None
FAD  A 600 ( 3.8A)
MBT  A 601 (-4.7A)
None
None
 1.35A 4pevB-3zyxA:
2.5		 4pevB-3zyxA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aib ORNITHINE
DECARBOXYLASE

(Entamoeba
histolytica) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 ASP A  32
ASN A 359
GLY A  35
PHE A  54
GLY A 361
 None
 1.31A 4pevB-4aibA:
undetectable		 4pevB-4aibA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		5 VAL A 390
ASN A 274
GLY A 480
ASP A 479
ASP A 292
 EDO  A1597 (-3.8A)
None
None
CA  A1592 (-2.1A)
FEO  A1595 ( 3.1A)
 1.35A 4pevB-4amfA:
undetectable		 4pevB-4amfA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		5 SER A1450
ASN A1449
GLY A1482
GLY A1464
ASP A1462
 None
 1.36A 4pevB-4aygA:
undetectable		 4pevB-4aygA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdb LISTERIOLYSIN O

(Listeria
monocytogenes) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		5 VAL A 138
SER A 404
ASN A 402
GLY A 222
GLY A  80
 None
None
NA  A1533 (-3.1A)
NA  A1533 (-3.4A)
None
 1.21A 4pevB-4cdbA:
undetectable		 4pevB-4cdbA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7u ENDOGLUCANASE II

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		5 VAL A  52
ASN A  10
GLY A  55
ASP A 135
GLY A  59
 None
 1.29A 4pevB-4d7uA:
undetectable		 4pevB-4d7uA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4u MANDALATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A 103
VAL A  37
SER A 320
GLY A 365
GLY A 316
 None
 1.38A 4pevB-4e4uA:
undetectable		 4pevB-4e4uA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eiu UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF12866
(DUF3823) 		5 VAL A  47
PHE A 136
ASN A 261
GLY A  99
GLY A 161
 None
None
None
None
PEG  A 304 ( 4.5A)
 1.11A 4pevB-4eiuA:
undetectable		 4pevB-4eiuA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glf RSFP

(uncultured
bacterium) 		PF01048
(PNP_UDP_1) 		5 ASP A 110
VAL A 220
ASN A 245
GLY A 163
ASP A 162
 None
 1.37A 4pevB-4glfA:
3.6		 4pevB-4glfA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq7 FLOCCULIN

(Saccharomyces
pastorianus) 		PF07691
(PA14) 		5 VAL A  41
SER A  97
PHE A 102
GLY A  71
GLY A 101
 None
 1.29A 4pevB-4gq7A:
undetectable		 4pevB-4gq7A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN

(Thermotoga
maritima;
Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		5 VAL A  21
SER A 452
ASP A 423
GLY A 453
ASP A 388
 None
 1.40A 4pevB-4gxpA:
undetectable		 4pevB-4gxpA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ASP A 524
SER A 520
ASN A 499
GLY A 418
GLY A 521
 None
 1.31A 4pevB-4h1sA:
undetectable		 4pevB-4h1sA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE

(Vitis vinifera) 		PF00701
(DHDPS) 		5 VAL A  66
SER A  95
PHE A  92
ASP A  50
GLY A  93
 None
 1.38A 4pevB-4hnnA:
undetectable		 4pevB-4hnnA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inz SOLUBLE EPOXIDE
HYDROLASE

(Bacillus
megaterium) 		PF00561
(Abhydrolase_1) 		5 ASP A  32
SER A 266
GLY A  29
ASP A  97
ASP A 239
 None
None
None
PEG  A 302 ( 4.7A)
None
 1.34A 4pevB-4inzA:
4.6		 4pevB-4inzA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 ASP A 119
SER A  98
GLY A 124
PHE A 141
GLY A 315
 None
 1.41A 4pevB-4kpgA:
4.8		 4pevB-4kpgA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY

(Thermococcus
kodakarensis) 		PF00375
(SDF) 		5 VAL A 416
SER A 303
PHE A 304
GLY A  84
GLY A 300
 None
 1.24A 4pevB-4ky0A:
undetectable		 4pevB-4ky0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)

(Candida
albicans) 		PF01965
(DJ-1_PfpI) 		5 ASP A 204
ASN A 218
GLY A 201
PHE A 206
GLY A 216
 None
 0.97A 4pevB-4lruA:
3.4		 4pevB-4lruA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Escherichia
coli) 		PF02733
(Dak1) 		5 VAL A 282
GLY A 295
PHE A 228
PHE A 328
GLY A 327
 None
 1.21A 4pevB-4lryA:
2.8		 4pevB-4lryA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 ASP A 119
SER A  98
GLY A 124
PHE A 141
GLY A 315
 None
 1.39A 4pevB-4m1zA:
5.3		 4pevB-4m1zA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)

(Parkia
biglobosa) 		PF01419
(Jacalin) 		5 ASP A  17
SER A  40
GLY A  16
ASP A 140
GLY A  56
 None
None
MMA  A 501 (-3.3A)
MMA  A 501 (-2.6A)
None
 1.37A 4pevB-4mq0A:
undetectable		 4pevB-4mq0A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)

(Parkia
biglobosa) 		PF01419
(Jacalin) 		5 ASP A 285
VAL A 240
GLY A 164
ASP A 165
PHE A 238
 MMA  A 503 (-3.0A)
None
MMA  A 503 (-3.8A)
MMA  A 503 (-2.6A)
MMA  A 503 ( 4.4A)
 1.41A 4pevB-4mq0A:
undetectable		 4pevB-4mq0A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)

(Parkia
biglobosa) 		PF01419
(Jacalin) 		5 ASP A 311
SER A 334
GLY A 310
ASP A 434
GLY A 350
 None
None
MMA  A 502 (-3.5A)
MMA  A 502 (-2.6A)
None
 1.34A 4pevB-4mq0A:
undetectable		 4pevB-4mq0A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf) 		5 ASP A 302
SER A 160
ASN A 156
GLY A 149
GLY A 215
 None
None
None
None
CA  A 401 ( 4.7A)
 1.23A 4pevB-4o6mA:
undetectable		 4pevB-4o6mA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q68 UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF07313
(DUF1460) 		5 ASP A 197
VAL A 257
GLY A 196
ASP A 195
GLY A 189
 None
 1.09A 4pevB-4q68A:
undetectable		 4pevB-4q68A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF17033
(Peptidase_M99)
PF17129
(Peptidase_M99_C)
PF17130
(Peptidase_M99_m) 		5 VAL A  75
ASP A  48
PHE A  53
GLY A  52
ASP A 129
 None
 1.42A 4pevB-4q6pA:
2.5		 4pevB-4q6pA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt9 PUTATIVE
GLUCOAMYLASE

(Bacteroides
caccae) 		PF10091
(Glycoamylase) 		5 SER A 408
GLY A 352
ASP A 351
GLY A 365
ASP A 411
 None
 1.03A 4pevB-4qt9A:
undetectable		 4pevB-4qt9A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY

(Trichormus
variabilis) 		PF13458
(Peripla_BP_6) 		5 VAL A 287
SER A 332
PHE A 331
GLY A 281
ASP A 280
 None
GOL  A 503 ( 3.9A)
PRO  A 501 (-4.3A)
PRO  A 501 ( 4.6A)
PRO  A 501 (-3.7A)
 1.20A 4pevB-4rdcA:
10.5		 4pevB-4rdcA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 ASP A2055
GLY A2056
ASP A2057
GLY A1979
ASP A2098
 MG  A4404 (-3.5A)
None
None
None
None
 1.26A 4pevB-4rh7A:
undetectable		 4pevB-4rh7A:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		5 SER A 622
PHE A 642
ASP A 538
GLY A 640
ASP A 623
 None
 1.34A 4pevB-4rkuA:
undetectable		 4pevB-4rkuA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjb PUTATIVE
AMIDOHYDROLASE/PEPTI
DASE

(Burkholderia
cenocepacia) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ASP A  64
VAL A 183
GLY A  67
PHE A 138
GLY A 157
 None
 1.35A 4pevB-4wjbA:
undetectable		 4pevB-4wjbA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ASP A 216
SER A  53
GLY A 217
GLY A  50
ASP A  54
 None
None
None
None
PEG  A1205 ( 4.5A)
 1.36A 4pevB-4xeeA:
undetectable		 4pevB-4xeeA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9d C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		5 VAL A 142
SER A 158
GLY A  93
PHE A  97
GLY A 146
 None
None
NAI  A 401 ( 4.4A)
None
None
 1.43A 4pevB-4y9dA:
5.8		 4pevB-4y9dA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo3 ACYLHOMOSERINE
LACTONASE

(Chryseobacterium
sp. StRB126) 		PF00753
(Lactamase_B) 		5 ASP A  57
PHE A 123
GLY A 122
GLY A  41
ASP A  38
 None
 1.15A 4pevB-4zo3A:
undetectable		 4pevB-4zo3A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anp BA41

(Bizionia
argentinensis) 		PF04536
(TPM_phosphatase) 		5 ASP A 147
ASP A 166
PHE A 151
GLY A 159
LYS A  65
 None
 1.23A 4pevB-5anpA:
undetectable		 4pevB-5anpA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA

(Mycolicibacterium
thermoresistibile) 		no annotation 5 VAL C 290
GLY C 265
ASP C 268
PHE C 262
GLY C 125
 None
 1.25A 4pevB-5cw2C:
5.0		 4pevB-5cw2C:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 5 ASP A 286
ASN A 283
GLY A 304
GLY A 221
ASP A 224
 None
 1.32A 4pevB-5f75A:
undetectable		 4pevB-5f75A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		5 ASP A  63
PHE A 114
GLY A 112
ASP A 118
LYS A  85
 None
 1.25A 4pevB-5f7uA:
undetectable		 4pevB-5f7uA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 VAL A 381
GLY A 405
ASP A 403
PHE A 349
ASP A 346
 None
 1.37A 4pevB-5gmhA:
undetectable		 4pevB-5gmhA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ha4 DIAMINOPIMELATE
EPIMERASE

(Acinetobacter
baumannii) 		PF01678
(DAP_epimerase) 		5 VAL A 243
GLY A 223
PHE A 125
GLY A 231
ASP A 154
 None
 1.39A 4pevB-5ha4A:
undetectable		 4pevB-5ha4A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5h INNER MEMBRANE
PROTEIN YEJM

(Escherichia
coli) 		PF00884
(Sulfatase)
PF11893
(DUF3413) 		5 VAL A 471
GLY A 269
ASP A 268
GLY A 305
ASP A 303
 None
 1.27A 4pevB-5i5hA:
undetectable		 4pevB-5i5hA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ASP A1419
SER A1415
GLY A1395
PHE A  19
GLY A1413
 None
 1.34A 4pevB-5ip9A:
undetectable		 4pevB-5ip9A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ASP A1419
VAL A  17
SER A1415
GLY A1395
GLY A1413
 None
 0.99A 4pevB-5ip9A:
undetectable		 4pevB-5ip9A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 ASP A 616
VAL A 612
ASN A 311
GLY A 630
ASP A 622
 None
 1.43A 4pevB-5k3hA:
undetectable		 4pevB-5k3hA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1q METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT BETA
METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT GAMMA

(Methanothermococcus
thermolithotrophicus) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 VAL C 238
SER B 289
PHE B 291
GLY B 343
GLY C  10
 None
 1.22A 4pevB-5n1qC:
undetectable		 4pevB-5n1qC:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-) 		no annotation 5 ASP A 286
ASN A 283
GLY A 304
GLY A 221
ASP A 224
 None
 1.31A 4pevB-5oexA:
undetectable		 4pevB-5oexA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		5 ASP A 290
VAL A 287
PHE A 758
GLY A 746
GLY A 282
 None
None
None
None
PO4  A 902 (-3.6A)
 1.40A 4pevB-5te1A:
8.2		 4pevB-5te1A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgz BETA-GLYCOSIDASE

(uncultured
microorganism) 		no annotation 5 VAL A  18
SER A 436
ASP A 407
GLY A 437
ASP A 373
 None
 1.39A 4pevB-5xgzA:
undetectable		 4pevB-5xgzA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xru ADENYLATE KINASE

(Notothenia
coriiceps) 		no annotation 5 VAL A  67
SER A  38
GLY A  40
ASP A  93
LYS A  21
 AP5  A 201 (-4.0A)
AP5  A 201 ( 4.8A)
AP5  A 201 (-3.5A)
AP5  A 201 ( 4.7A)
AP5  A 201 (-2.8A)
 1.42A 4pevB-5xruA:
3.5		 4pevB-5xruA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ASP A 588
VAL A 594
GLY A 587
PHE A 555
PHE A 390
 None
 1.34A 4pevB-5xxoA:
4.0		 4pevB-5xxoA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6al7 12-EPI-HAPALINDOLE
C/U SYNTHASE

(Fischerella sp.
ATCC 43239) 		no annotation 5 ASN A 137
GLY A 140
PHE A 210
GLY A 212
ASP A 214
 CA  A 301 (-3.1A)
None
None
None
None
 1.10A 4pevB-6al7A:
undetectable		 4pevB-6al7A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 5 SER A 562
GLY A 331
ASP A 326
PHE A 755
GLY A 745
 None
 1.33A 4pevB-6b6lA:
undetectable		 4pevB-6b6lA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpe TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE

(Thermotoga
maritima) 		no annotation 5 VAL B 167
SER B 159
PHE B 209
PHE B 164
GLY B 161
 None
None
None
PEG  B 402 ( 4.8A)
PEG  B 402 ( 3.8A)
 1.42A 4pevB-6fpeB:
undetectable		 4pevB-6fpeB:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gup -

(-) 		no annotation 5 SER A 125
GLY A  47
ASP A  46
PHE A  40
GLY A 120
 None
 1.14A 4pevB-6gupA:
5.9		 4pevB-6gupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)

(Thermococcus
kodakarensis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 PRO A 324
LEU A 325
GLN A 416
 None
 0.50A 4pevB-1b8aA:
undetectable		 4pevB-1b8aA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Homo sapiens) 		PF00490
(ALAD) 		3 PRO A  67
LEU A  68
GLN A 325
 None
 0.60A 4pevB-1e51A:
undetectable		 4pevB-1e51A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eo8 ANTIBODY (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H  16
LEU H  82
GLN H  81
 None
 0.72A 4pevB-1eo8H:
undetectable		 4pevB-1eo8H:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fux HYPOTHETICAL 19.5
KDA PROTEIN IN
EMRE-RUS INTERGENIC
REGION

(Escherichia
coli) 		PF01161
(PBP) 		3 PRO A  77
LEU A  76
GLN A  94
 None
 0.69A 4pevB-1fuxA:
undetectable		 4pevB-1fuxA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7j PROTEIN YCIO

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC) 		3 PRO A  60
LEU A  59
GLN A 113
 None
 0.54A 4pevB-1k7jA:
undetectable		 4pevB-1k7jA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8c CREB-BINDING PROTEIN

(Mus musculus) 		PF02135
(zf-TAZ) 		3 PRO A  38
LEU A  37
GLN A  11
 None
 0.70A 4pevB-1l8cA:
undetectable		 4pevB-1l8cA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF02548
(Pantoate_transf) 		3 PRO A  86
LEU A  85
GLN A  95
 None
 0.67A 4pevB-1m3uA:
undetectable		 4pevB-1m3uA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Geobacillus
stearothermophilus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 PRO A 498
LEU A 497
GLN A 323
 None
 0.56A 4pevB-1o99A:
4.2		 4pevB-1o99A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 PRO A 110
LEU A 109
GLN A 117
 None
 0.70A 4pevB-1qorA:
3.3		 4pevB-1qorA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ECDYSONE RECEPTOR

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		3 PRO D 519
LEU D 522
GLN D 348
 None
 0.71A 4pevB-1r20D:
undetectable		 4pevB-1r20D:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryn PROTEIN CRS2

(Zea mays) 		PF01195
(Pept_tRNA_hydro) 		3 PRO A  99
LEU A  98
GLN A 192
 PRO  A  99 ( 1.1A)
LEU  A  98 ( 0.5A)
GLN  A 192 ( 0.6A)
 0.53A 4pevB-1rynA:
5.0		 4pevB-1rynA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp4 UV EXCISION REPAIR
PROTEIN RAD23
HOMOLOG A

(Homo sapiens) 		PF09280
(XPC-binding) 		3 PRO A 231
LEU A 232
GLN A 240
 None
 0.52A 4pevB-1tp4A:
undetectable		 4pevB-1tp4A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0k GENE PRODUCT PA4716

(Pseudomonas
aeruginosa) 		PF02567
(PhzC-PhzF) 		3 PRO A  15
LEU A  16
GLN A   7
 None
 0.73A 4pevB-1u0kA:
undetectable		 4pevB-1u0kA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, ALPHA
SUBUNIT
PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 PRO A 139
LEU A 138
GLN B  96
 None
 0.73A 4pevB-1w85A:
2.5		 4pevB-1w85A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsa BIS(5'-NUCLEOSYL)-TE
TRAPHOSPHATASE

(Homo sapiens) 		PF00293
(NUDIX) 		3 PRO A  45
LEU A  33
GLN A 132
 None
 0.70A 4pevB-1xsaA:
undetectable		 4pevB-1xsaA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		3 PRO A 313
LEU A 312
GLN A 465
 None
 0.62A 4pevB-1yiqA:
undetectable		 4pevB-1yiqA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		PF01082
(Cu2_monooxygen)
PF03712
(Cu2_monoox_C) 		3 PRO A 151
LEU A 150
GLN A 198
 None
GOL  A 701 (-4.5A)
GOL  A 704 (-3.6A)
 0.61A 4pevB-1yjkA:
undetectable		 4pevB-1yjkA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5x ECDYSONE RECEPTOR
LIGAND BINDING
DOMAIN

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		3 PRO E 405
LEU E 408
GLN E 236
 None
 0.52A 4pevB-1z5xE:
undetectable		 4pevB-1z5xE:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		3 PRO A 194
LEU A 169
GLN A 158
 None
 0.71A 4pevB-2bp1A:
undetectable		 4pevB-2bp1A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2diw PUTATIVE RNA-BINDING
PROTEIN 16

(Homo sapiens) 		PF04818
(CTD_bind) 		3 PRO A 139
LEU A 140
GLN A 106
 None
 0.48A 4pevB-2diwA:
undetectable		 4pevB-2diwA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1) 		PF01499
(Herpes_UL25) 		3 PRO A 327
LEU A 326
GLN A 372
 None
 0.65A 4pevB-2f5uA:
undetectable		 4pevB-2f5uA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lwx ZUOTIN

(Saccharomyces
cerevisiae) 		PF16717
(RAC_head) 		3 PRO A 425
LEU A 424
GLN A 380
 None
 0.44A 4pevB-2lwxA:
undetectable		 4pevB-2lwxA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 PRO A 700
LEU A 701
GLN A 708
 None
 0.38A 4pevB-2nq5A:
3.4		 4pevB-2nq5A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE

(Rattus
norvegicus) 		PF00171
(Aldedh) 		3 PRO A 627
LEU A 626
GLN A 457
 None
 0.71A 4pevB-2o2qA:
2.3		 4pevB-2o2qA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oca ATP-DEPENDENT DNA
HELICASE UVSW

(Escherichia
virus T4) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		3 PRO A  61
LEU A  60
GLN A  67
 None
 0.70A 4pevB-2ocaA:
2.7		 4pevB-2ocaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		3 PRO A 282
LEU A 281
GLN A 336
 FAD  A 500 (-4.5A)
None
None
 0.72A 4pevB-2qa2A:
undetectable		 4pevB-2qa2A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 PRO A 223
LEU A 224
GLN A 204
 None
 0.63A 4pevB-2qdeA:
2.3		 4pevB-2qdeA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkw CARBOXYLESTERASE

(Alcaligenes sp.) 		no annotation 3 PRO A 212
LEU A 190
GLN A 104
 None
 0.69A 4pevB-2wkwA:
3.6		 4pevB-2wkwA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgv PSIV CAPSID
N-TERMINAL DOMAIN

(Microcebus
murinus) 		PF00607
(Gag_p24) 		3 PRO A   1
LEU A  47
GLN A  54
 None
 0.57A 4pevB-2xgvA:
undetectable		 4pevB-2xgvA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		3 PRO A 170
LEU A 171
GLN A 117
 None
 0.50A 4pevB-2xydA:
undetectable		 4pevB-2xydA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuc DNA REPAIR AND
RECOMBINATION
PROTEIN RADA

(Sulfolobus
solfataricus) 		PF08423
(Rad51)
PF14520
(HHH_5) 		3 PRO A 281
LEU A 237
GLN A 230
 None
 0.62A 4pevB-2zucA:
3.6		 4pevB-2zucA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1d REGULATORY PROTEIN
RECX

(Escherichia
coli) 		PF02631
(RecX) 		3 PRO A 134
LEU A 133
GLN A 144
 None
 0.58A 4pevB-3c1dA:
undetectable		 4pevB-3c1dA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		3 PRO A  99
LEU A  98
GLN A  76
 None
 0.68A 4pevB-3ciyA:
undetectable		 4pevB-3ciyA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 PRO A 171
LEU A 230
GLN A 154
 None
 0.65A 4pevB-3dkhA:
undetectable		 4pevB-3dkhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evt PHOSPHOGLYCERATE
DEHYDROGENASE

(Lactobacillus
plantarum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 PRO A 260
LEU A 259
GLN A 267
 None
 0.56A 4pevB-3evtA:
2.1		 4pevB-3evtA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Nocardioides
aromaticivorans) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		3 PRO A 156
LEU A 155
GLN A 136
 None
 0.73A 4pevB-3gcfA:
undetectable		 4pevB-3gcfA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 PRO A  41
LEU A  67
GLN A 368
 None
 0.69A 4pevB-3h9uA:
5.1		 4pevB-3h9uA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 4

(Thermus
thermophilus) 		PF00346
(Complex1_49kDa) 		3 PRO 4 337
LEU 4 105
GLN 4 308
 None
 0.71A 4pevB-3i9v4:
undetectable		 4pevB-3i9v4:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq1 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 PRO A 237
LEU A 238
GLN A 211
 None
None
CA  A   5 (-3.2A)
 0.71A 4pevB-3jq1A:
undetectable		 4pevB-3jq1A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mog PROBABLE
3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Escherichia
coli) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 PRO A 230
LEU A 231
GLN A 265
 None
 0.67A 4pevB-3mogA:
4.5		 4pevB-3mogA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Kosmotoga
olearia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 PRO A 237
LEU A 238
GLN A 219
 None
 0.68A 4pevB-3mwcA:
3.1		 4pevB-3mwcA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 PRO A  44
LEU A  70
GLN A 403
 None
 0.71A 4pevB-3n58A:
3.4		 4pevB-3n58A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt1 UPF0364 PROTEIN
YMR027W

(Saccharomyces
cerevisiae) 		PF01937
(DUF89) 		3 PRO A 408
LEU A 409
GLN A 374
 None
 0.60A 4pevB-3pt1A:
3.1		 4pevB-3pt1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4r PHOSPHOPROTEIN

(Lettuce
necrotic
yellows
cytorhabdovirus) 		no annotation 3 PRO A  48
LEU A  46
GLN A  55
 None
 0.68A 4pevB-3t4rA:
undetectable		 4pevB-3t4rA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uoe DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02615
(Ldh_2) 		3 PRO A  50
LEU A  53
GLN A  29
 None
 0.63A 4pevB-3uoeA:
undetectable		 4pevB-3uoeA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v6a APOPTOSIS INHIBITOR
5

(Homo sapiens) 		PF05918
(API5) 		3 PRO A 247
LEU A 248
GLN A 205
 None
 0.71A 4pevB-3v6aA:
undetectable		 4pevB-3v6aA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		3 PRO A 565
LEU A 564
GLN A  34
 None
 0.64A 4pevB-3w9hA:
undetectable		 4pevB-3w9hA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		3 PRO A 565
LEU A 564
GLN A  34
 None
 0.59A 4pevB-3w9iA:
undetectable		 4pevB-3w9iA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1

(Candida
parapsilosis) 		PF00248
(Aldo_ket_red) 		3 PRO A 224
LEU A 225
GLN A 283
 None
 0.49A 4pevB-3wg6A:
undetectable		 4pevB-3wg6A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5o BIFUNCTIONAL PROTEIN
FOLD

(Pseudomonas
aeruginosa) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		3 PRO A 102
LEU A 101
GLN A  76
 None
 0.65A 4pevB-4a5oA:
4.4		 4pevB-4a5oA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq7 MEMBRANE PROTEIN
PHI6 P5

(Pseudomonas
virus phi6) 		PF10464
(Peptidase_U40) 		3 PRO A  53
LEU A  52
GLN A 199
 None
 0.70A 4pevB-4dq7A:
undetectable		 4pevB-4dq7A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ebj AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE

(Pseudomonas
aeruginosa) 		PF01909
(NTP_transf_2) 		3 PRO A  92
LEU A  91
GLN A 176
 None
 0.70A 4pevB-4ebjA:
undetectable		 4pevB-4ebjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		3 PRO A  25
LEU A  26
GLN A  33
 None
 0.69A 4pevB-4efcA:
undetectable		 4pevB-4efcA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		3 PRO A 238
LEU A 237
GLN A 252
 None
 0.71A 4pevB-4ez5A:
undetectable		 4pevB-4ez5A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7g TALIN-1

(Mus musculus) 		PF00373
(FERM_M)
PF02174
(IRS) 		3 PRO A 267
LEU A 266
GLN A 273
 None
 0.70A 4pevB-4f7gA:
undetectable		 4pevB-4f7gA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		3 PRO A 283
LEU A 282
GLN A 289
 PRO  A 283 ( 1.1A)
LEU  A 282 ( 0.6A)
GLN  A 289 ( 0.6A)
 0.58A 4pevB-4hneA:
undetectable		 4pevB-4hneA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE

(Streptomyces
atroolivaceus) 		no annotation 3 PRO A 167
LEU A 166
GLN A  96
 None
 0.63A 4pevB-4hzpA:
undetectable		 4pevB-4hzpA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		3 PRO A 491
LEU A 490
GLN A 495
 None
 0.65A 4pevB-4ipeA:
undetectable		 4pevB-4ipeA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwb FLIC, FLIS CHIMERA

(Aquifex
aeolicus) 		PF00700
(Flagellin_C)
PF02561
(FliS) 		3 PRO A  58
LEU A  59
GLN A  30
 None
 0.69A 4pevB-4iwbA:
undetectable		 4pevB-4iwbA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 3 PRO A 440
LEU A 444
GLN A 391
 None
 0.72A 4pevB-4jzaA:
undetectable		 4pevB-4jzaA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus) 		PF01494
(FAD_binding_3) 		3 PRO A  84
LEU A  83
GLN A 303
 None
 0.50A 4pevB-4k5rA:
2.1		 4pevB-4k5rA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		3 PRO A 842
LEU A 843
GLN A 904
 None
 0.68A 4pevB-4lglA:
6.5		 4pevB-4lglA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 PRO A  47
LEU A  73
GLN A 408
 None
 0.73A 4pevB-4lvcA:
5.4		 4pevB-4lvcA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4of7 PROTEIN SYG-1,
ISOFORM B

(Caenorhabditis
elegans) 		PF07679
(I-set) 		3 PRO A  71
LEU A  70
GLN A  54
 None
 0.71A 4pevB-4of7A:
undetectable		 4pevB-4of7A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt ECDYSONE RECEPTOR

(Pediculus
humanus) 		PF00104
(Hormone_recep) 		3 PRO E 509
LEU E 512
GLN E 340
 None
 0.73A 4pevB-4oztE:
undetectable		 4pevB-4oztE:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puc SUSD HOMOLOG

(Bacteroides
uniformis) 		PF12741
(SusD-like) 		3 PRO A 270
LEU A 271
GLN A  66
 None
 0.70A 4pevB-4pucA:
undetectable		 4pevB-4pucA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2v CYSTEINE SYNTHETASE

(Helicobacter
pylori) 		PF00291
(PALP) 		3 PRO A 283
LEU A 282
GLN A 287
 None
 0.64A 4pevB-4r2vA:
2.5		 4pevB-4r2vA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		3 PRO A 226
LEU A 180
GLN A 312
 None
 0.67A 4pevB-4rbnA:
4.4		 4pevB-4rbnA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		3 PRO A 249
LEU A 250
GLN A 174
 None
 0.60A 4pevB-4uvkA:
undetectable		 4pevB-4uvkA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3i VCA0115

(Vibrio cholerae) 		PF09850
(DotU) 		3 PRO A  45
LEU A  46
GLN A  68
 None
 0.59A 4pevB-4v3iA:
undetectable		 4pevB-4v3iA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 PRO A 507
LEU A 506
GLN A 514
 None
 0.66A 4pevB-4wz9A:
undetectable		 4pevB-4wz9A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 PROTEIN ATS1

(Saccharomyces
cerevisiae) 		PF00415
(RCC1) 		3 PRO B 209
LEU B 208
GLN B 217
 None
 0.62A 4pevB-4x33B:
undetectable		 4pevB-4x33B:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00659
(POLO_box) 		3 PRO A 590
LEU A 589
GLN A 502
 None
 0.71A 4pevB-4xb0A:
undetectable		 4pevB-4xb0A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybh ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Homo sapiens) 		PF00047
(ig)
PF08205
(C2-set_2)
PF13895
(Ig_2) 		3 PRO A 289
LEU A 288
GLN A 294
 None
 0.63A 4pevB-4ybhA:
undetectable		 4pevB-4ybhA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 PRO A 445
LEU A 739
GLN A 482
 None
 0.69A 4pevB-4ztxA:
2.0		 4pevB-4ztxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1r 7S VICILIN

(Carya
illinoinensis) 		PF00190
(Cupin_1) 		3 PRO A 431
LEU A 430
GLN A 543
 None
 0.66A 4pevB-5e1rA:
undetectable		 4pevB-5e1rA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 PRO A 677
LEU A 676
GLN A 680
 None
 0.60A 4pevB-5f7cA:
undetectable		 4pevB-5f7cA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		3 PRO A  41
LEU A  42
GLN A  51
 None
 0.46A 4pevB-5karA:
undetectable		 4pevB-5karA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0t ALPHA-KETOGLUTARATE-
DEPENDENT NON-HEME
IRON OXYGENASE EASH

(Aspergillus
japonicus) 		PF05721
(PhyH) 		3 PRO A 243
LEU A 242
GLN A 255
 None
 0.71A 4pevB-5m0tA:
undetectable		 4pevB-5m0tA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpi GRAINYHEAD-LIKE
PROTEIN 1 HOMOLOG

(Homo sapiens) 		no annotation 3 PRO A 392
LEU A 391
GLN A 317
 None
 0.61A 4pevB-5mpiA:
undetectable		 4pevB-5mpiA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr7 GRAINYHEAD-LIKE
PROTEIN 2 HOMOLOG

(Homo sapiens) 		no annotation 3 PRO A 388
LEU A 387
GLN A 313
 None
 0.65A 4pevB-5mr7A:
undetectable		 4pevB-5mr7A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 3 PRO A  45
LEU A  44
GLN A  29
 None
 0.68A 4pevB-5n7qA:
undetectable		 4pevB-5n7qA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		3 PRO A  61
LEU A  60
GLN A 167
 None
 0.57A 4pevB-5n8oA:
undetectable		 4pevB-5n8oA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2

(Homo sapiens) 		no annotation 3 PRO A 645
LEU A 644
GLN A 636
 None
 0.52A 4pevB-5o0yA:
undetectable		 4pevB-5o0yA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqp CONDENSIN COMPLEX
SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 3 PRO A 459
LEU A 460
GLN A 424
 None
 0.59A 4pevB-5oqpA:
undetectable		 4pevB-5oqpA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szw ELAV-LIKE PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1) 		3 PRO A  30
LEU A  29
GLN A  35
 None
 0.58A 4pevB-5szwA:
undetectable		 4pevB-5szwA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE

(Bacillus
subtilis) 		PF04055
(Radical_SAM)
PF13394
(Fer4_14) 		3 PRO A 230
LEU A 229
GLN A  16
 None
None
7C5  A 302 (-3.5A)
 0.60A 4pevB-5th5A:
undetectable		 4pevB-5th5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tse LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Acinetobacter
baumannii) 		no annotation 3 PRO A 165
LEU A 164
GLN A 105
 None
 0.64A 4pevB-5tseA:
undetectable		 4pevB-5tseA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio;
Streptococcus
pyogenes) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		3 PRO A 491
LEU A 490
GLN A 495
 None
 0.67A 4pevB-5tthA:
undetectable		 4pevB-5tthA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		3 PRO A1625
LEU A1624
GLN A1435
 None
 0.54A 4pevB-5u1sA:
2.8		 4pevB-5u1sA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v33 REACTION CENTER
PROTEIN H CHAIN

(Rhodobacter
sphaeroides) 		PF03967
(PRCH)
PF05239
(PRC) 		3 PRO H 152
LEU H 151
GLN H 199
 None
 0.69A 4pevB-5v33H:
undetectable		 4pevB-5v33H:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		no annotation 3 PRO A 151
LEU A 150
GLN A 198
 None
 0.63A 4pevB-5wm0A:
undetectable		 4pevB-5wm0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1i CYTOCHROME P450

(Streptomyces
graminofaciens) 		PF00067
(p450) 		3 PRO A  43
LEU A  44
GLN A  64
 None
 0.44A 4pevB-5y1iA:
undetectable		 4pevB-5y1iA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 3 PRO B 327
LEU B 326
GLN B 333
 None
 0.73A 4pevB-5y58B:
3.1		 4pevB-5y58B:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh0 DRFAM20C1

(Danio rerio) 		no annotation 3 PRO A 143
LEU A 144
GLN A 553
 None
 0.73A 4pevB-5yh0A:
undetectable		 4pevB-5yh0A:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5k NETRIN RECEPTOR DCC

(Rattus
norvegicus) 		no annotation 3 PRO A 193
LEU A 192
GLN A 244
 None
 0.71A 4pevB-5z5kA:
undetectable		 4pevB-5z5kA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d14 TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		no annotation 3 PRO A 491
LEU A 490
GLN A 495
 None
 0.64A 4pevB-6d14A:
undetectable		 4pevB-6d14A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 3 PRO A 354
LEU A 353
GLN A   6
 None
 0.66A 4pevB-6fikA:
undetectable		 4pevB-6fikA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fra HUMAN T-CELL
RECEPTOR F11 ALPHA
CHAIN

(Homo sapiens) 		no annotation 3 PRO A 112
LEU A 111
GLN A 143
 None
EDO  A 305 (-4.0A)
None
 0.60A 4pevB-6fraA:
undetectable		 4pevB-6fraA:
11.76