SIMILAR PATTERNS OF AMINO ACIDS FOR 4PEV_A_ADNA501_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea) 		PF00135
(COesterase) 		3 PRO A  65
LEU A 297
HIS A 449
 None
None
CLL  A 801 (-4.8A)
 0.68A 4pevA-1cleA:
2.4		 4pevA-1cleA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		3 PRO A 539
LEU A 538
HIS A 528
 None
None
XYP  A1719 (-4.4A)
 0.69A 4pevA-1gqjA:
3.8		 4pevA-1gqjA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		3 PRO A  65
LEU A 297
HIS A 449
 None
 0.57A 4pevA-1gz7A:
2.4		 4pevA-1gz7A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 PRO A  51
LEU A  54
HIS A 177
 None
None
CU  A 629 (-3.2A)
 0.62A 4pevA-1llaA:
undetectable		 4pevA-1llaA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1on0 YYCN PROTEIN

(Bacillus
subtilis) 		PF00583
(Acetyltransf_1) 		3 PRO A  52
LEU A  51
HIS A  61
 None
 0.68A 4pevA-1on0A:
undetectable		 4pevA-1on0A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9e METHYL PARATHION
HYDROLASE

(Pseudomonas sp.
WBC-3) 		PF00753
(Lactamase_B) 		3 PRO A  68
LEU A  67
HIS A 149
 None
None
ZN  A 402 (-3.1A)
 0.70A 4pevA-1p9eA:
undetectable		 4pevA-1p9eA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtk COMPLEMENT FACTOR B

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		3 PRO A 599
LEU A 598
HIS A 717
 None
 0.73A 4pevA-1rtkA:
5.5		 4pevA-1rtkA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1siq GLUTARYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 PRO A 234
LEU A 233
HIS A 106
 None
 0.70A 4pevA-1siqA:
undetectable		 4pevA-1siqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
MEDIUM SUBUNIT

(Pseudomonas
putida) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		3 PRO C  38
LEU C  39
HIS C 155
 None
 0.69A 4pevA-1t3qC:
undetectable		 4pevA-1t3qC:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj7 ARGININOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		3 PRO A 194
LEU A 195
HIS A 104
 None
 0.61A 4pevA-1tj7A:
undetectable		 4pevA-1tj7A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tme THEILER'S MURINE
ENCEPHALOMYELITIS
VIRUS (SUBUNIT VP1)
THEILER'S MURINE
ENCEPHALOMYELITIS
VIRUS (SUBUNIT VP2)

(Cardiovirus B) 		PF00073
(Rhv)
no annotation 		3 PRO 1  72
LEU 1  73
HIS 2 180
 None
 0.68A 4pevA-1tme1:
undetectable		 4pevA-1tme1:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufh YYCN PROTEIN

(Bacillus
subtilis) 		PF00583
(Acetyltransf_1) 		3 PRO A  52
LEU A  51
HIS A  61
 None
 0.71A 4pevA-1ufhA:
undetectable		 4pevA-1ufhA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		3 PRO A 296
LEU A 243
HIS A 192
 None
 0.69A 4pevA-1xjeA:
2.2		 4pevA-1xjeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ylo HYPOTHETICAL PROTEIN
SF2450

(Shigella
flexneri) 		PF05343
(Peptidase_M42) 		3 PRO A 156
LEU A 155
HIS A 306
 None
 0.65A 4pevA-1yloA:
3.6		 4pevA-1yloA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		3 PRO A 363
LEU A 366
HIS A  16
 None
 0.61A 4pevA-1yniA:
undetectable		 4pevA-1yniA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7o HUNTINGTIN
INTERACTING PROTEIN
B

(Homo sapiens) 		PF08236
(SRI) 		3 PRO A  75
LEU A  78
HIS A  62
 None
 0.67A 4pevA-2a7oA:
undetectable		 4pevA-2a7oA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dxb THIOCYANATE
HYDROLASE SUBUNIT
GAMMA

(Thiobacillus
thioparus) 		PF02979
(NHase_alpha) 		3 PRO C 171
LEU C 170
HIS C 124
 None
 0.72A 4pevA-2dxbC:
undetectable		 4pevA-2dxbC:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN

(Daboia
siamensis) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		3 PRO A  49
LEU A  50
HIS A 187
 None
 0.47A 4pevA-2e3xA:
3.8		 4pevA-2e3xA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9f ARGININOSUCCINATE
LYASE

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		3 PRO A 197
LEU A 198
HIS A 105
 None
 0.67A 4pevA-2e9fA:
undetectable		 4pevA-2e9fA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2haj DNA PRIMASE

(Escherichia
coli) 		PF08278
(DnaG_DnaB_bind) 		3 PRO A 480
LEU A 479
HIS A 541
 None
 0.52A 4pevA-2hajA:
undetectable		 4pevA-2hajA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II

(Thermotoga
maritima) 		PF00586
(AIRS)
PF02769
(AIRS_C)
PF16904
(PurL_C) 		3 PRO A 572
LEU A 571
HIS A 556
 None
 0.63A 4pevA-2hruA:
undetectable		 4pevA-2hruA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 PRO A 333
LEU A 334
HIS A 287
 None
 0.61A 4pevA-2iukA:
undetectable		 4pevA-2iukA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		3 PRO A  15
LEU A  14
HIS A  21
 None
 0.60A 4pevA-2m56A:
undetectable		 4pevA-2m56A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ok3 PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE-LIKE 3

(Homo sapiens) 		PF00160
(Pro_isomerase) 		3 PRO A 135
LEU A 134
HIS A 148
 None
None
NI  A 802 (-3.2A)
 0.68A 4pevA-2ok3A:
undetectable		 4pevA-2ok3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ou6 HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF04978
(DUF664) 		3 PRO A 153
LEU A 151
HIS A 164
 None
None
GOL  A 304 (-4.1A)
 0.51A 4pevA-2ou6A:
undetectable		 4pevA-2ou6A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkh GLUCOSE-DEPENDENT
INSULINOTROPIC
POLYPEPTIDE RECEPTOR

(Homo sapiens) 		PF02793
(HRM) 		3 PRO A  89
LEU A  88
HIS A 115
 None
 0.69A 4pevA-2qkhA:
undetectable		 4pevA-2qkhA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvp UNCHARACTERIZED
PROTEIN

(Shewanella
amazonensis) 		PF04952
(AstE_AspA) 		3 PRO A 105
LEU A 104
HIS A 152
 None
 0.69A 4pevA-2qvpA:
2.5		 4pevA-2qvpA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfc PEROXIREDOXIN 5

(Arenicola
marina) 		PF08534
(Redoxin) 		3 PRO A 180
LEU A 183
HIS A  90
 None
 0.61A 4pevA-2wfcA:
undetectable		 4pevA-2wfcA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 PRO A  62
LEU A  61
HIS A  45
 None
 0.65A 4pevA-2wskA:
undetectable		 4pevA-2wskA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsx BETA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 PRO A  75
LEU A  78
HIS A  25
 None
 0.71A 4pevA-2xsxA:
undetectable		 4pevA-2xsxA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yeq ALKALINE PHOSPHATASE
D

(Bacillus
subtilis) 		PF09423
(PhoD)
PF16655
(PhoD_N) 		3 PRO A 108
LEU A 107
HIS A 264
 None
None
EDO  A 576 ( 4.3A)
 0.64A 4pevA-2yeqA:
2.2		 4pevA-2yeqA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ysk HYPOTHETICAL PROTEIN
TTHA1432

(Thermus
thermophilus) 		PF10025
(DUF2267) 		3 PRO A  63
LEU A  62
HIS A  44
 SO4  A 146 (-4.1A)
None
None
 0.69A 4pevA-2yskA:
undetectable		 4pevA-2yskA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		3 PRO A  50
LEU A  49
HIS A 313
 None
 0.72A 4pevA-2z8zA:
undetectable		 4pevA-2z8zA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Bacillus
subtilis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 PRO A  46
LEU A  45
HIS A  56
 None
 0.67A 4pevA-2zviA:
2.2		 4pevA-2zviA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1p RIBOSOME MATURATION
FACTOR RIMM

(Thermus
thermophilus) 		PF01782
(RimM)
PF05239
(PRC) 		3 PRO A  12
LEU A  19
HIS A  38
 None
 0.53A 4pevA-3a1pA:
undetectable		 4pevA-3a1pA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1o EUGENOL SYNTHASE

(Clarkia breweri) 		PF05368
(NmrA) 		3 PRO A  83
LEU A  82
HIS A  92
 NAP  A 401 (-3.8A)
None
None
 0.69A 4pevA-3c1oA:
6.4		 4pevA-3c1oA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doa FIBRINOGEN BINDING
PROTEIN

(Staphylococcus
aureus) 		PF05833
(FbpA) 		3 PRO A 203
LEU A 204
HIS A 241
 None
 0.64A 4pevA-3doaA:
undetectable		 4pevA-3doaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 PRO A 625
LEU A 624
HIS A 634
 None
 0.72A 4pevA-3dy5A:
undetectable		 4pevA-3dy5A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0f PUTATIVE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bifidobacterium
adolescentis) 		PF02811
(PHP) 		3 PRO A  29
LEU A  32
HIS A  17
 None
None
FE  A 303 (-3.3A)
 0.69A 4pevA-3e0fA:
undetectable		 4pevA-3e0fA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9p PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF12134
(PRP8_domainIV) 		3 PRO A1925
LEU A1924
HIS A1888
 None
 0.68A 4pevA-3e9pA:
2.3		 4pevA-3e9pA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec7 PUTATIVE
DEHYDROGENASE

(Salmonella
enterica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 PRO A 329
LEU A 328
HIS A 182
 None
 0.73A 4pevA-3ec7A:
6.7		 4pevA-3ec7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fru BETA-2-MICROGLOBULIN
NEONATAL FC RECEPTOR

(Rattus
norvegicus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 PRO A  22
LEU A  21
HIS B  31
 None
 0.72A 4pevA-3fruA:
undetectable		 4pevA-3fruA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1t TYPE I SITE-SPECIFIC
RESTRICTION-MODIFICA
TION SYSTEM, R
(RESTRICTION)
SUBUNIT

(Vibrio
vulnificus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF13588
(HSDR_N_2) 		3 PRO A 356
LEU A 202
HIS A 312
 None
 0.69A 4pevA-3h1tA:
undetectable		 4pevA-3h1tA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1j OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF00106
(adh_short) 		3 PRO A 138
LEU A 139
HIS A  89
 None
 0.66A 4pevA-3i1jA:
4.7		 4pevA-3i1jA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieh PUTATIVE
METALLOPEPTIDASE

(Shewanella
baltica) 		PF04952
(AstE_AspA) 		3 PRO A 106
LEU A 105
HIS A 153
 None
None
GOL  A 279 (-4.5A)
 0.67A 4pevA-3iehA:
undetectable		 4pevA-3iehA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 PRO A 116
LEU A 122
HIS A  96
 None
None
SO4  A 415 (-3.8A)
 0.72A 4pevA-3ifeA:
undetectable		 4pevA-3ifeA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifr CARBOHYDRATE KINASE,
FGGY

(Rhodospirillum
rubrum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 PRO A 345
LEU A 344
HIS A 493
 None
 0.67A 4pevA-3ifrA:
undetectable		 4pevA-3ifrA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv9 TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		PF03466
(LysR_substrate) 		3 PRO A 246
LEU A 245
HIS A 234
 None
 0.60A 4pevA-3jv9A:
2.3		 4pevA-3jv9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8p PROTEIN TRANSPORT
PROTEIN SEC39

(Saccharomyces
cerevisiae) 		PF08314
(Sec39) 		3 PRO D 525
LEU D 526
HIS D 576
 None
 0.69A 4pevA-3k8pD:
undetectable		 4pevA-3k8pD:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgj SINGLE-STRANDED
DNA-BINDING PROTEIN

(Bartonella
henselae) 		PF00436
(SSB) 		3 PRO A 102
LEU A 101
HIS A 109
 None
None
CA  A 149 (-3.4A)
 0.64A 4pevA-3lgjA:
undetectable		 4pevA-3lgjA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oce FUMARATE LYASE:DELTA
CRYSTALLIN

(Brucella
abortus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 PRO A 121
LEU A 115
HIS A 129
 None
 0.57A 4pevA-3oceA:
undetectable		 4pevA-3oceA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3puf RIBONUCLEASE H2
SUBUNIT B

(Homo sapiens) 		PF09468
(RNase_H2-Ydr279) 		3 PRO B  93
LEU B  94
HIS B 139
 None
 0.70A 4pevA-3pufB:
undetectable		 4pevA-3pufB:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qh4 ESTERASE LIPW

(Mycobacterium
marinum) 		PF07859
(Abhydrolase_3) 		3 PRO A 129
LEU A 132
HIS A 173
 None
 0.69A 4pevA-3qh4A:
4.7		 4pevA-3qh4A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF00215
(OMPdecase) 		3 PRO A 178
LEU A 192
HIS A 227
 IOD  A 287 ( 4.1A)
None
None
 0.68A 4pevA-3ru6A:
undetectable		 4pevA-3ru6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tiq SURFACE PROTEIN G

(Staphylococcus
aureus) 		PF07501
(G5)
PF17041
(SasG_E) 		3 PRO A 599
LEU A 600
HIS A 506
 None
 0.73A 4pevA-3tiqA:
undetectable		 4pevA-3tiqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		3 PRO A 465
LEU A 464
HIS A 535
 None
 0.68A 4pevA-3ui7A:
undetectable		 4pevA-3ui7A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE

(Microbacterium
saccharophilum) 		PF02435
(Glyco_hydro_68) 		3 PRO A 361
LEU A 360
HIS A 291
 None
None
FRU  A 603 (-4.3A)
 0.67A 4pevA-3vssA:
undetectable		 4pevA-3vssA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		3 PRO A 129
LEU A 133
HIS A 258
 None
 0.69A 4pevA-3wrcA:
undetectable		 4pevA-3wrcA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 PRO B1925
LEU B1924
HIS B1888
 None
 0.57A 4pevA-3zefB:
2.8		 4pevA-3zefB:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN

(Plasmodium
berghei;
synthetic
construct) 		PF00022
(Actin) 		3 PRO A 110
LEU A 111
HIS A 174
 None
 0.63A 4pevA-4cbwA:
undetectable		 4pevA-4cbwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgs DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 PRO A  69
LEU A  68
HIS A  31
 None
 0.65A 4pevA-4dgsA:
5.4		 4pevA-4dgsA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eay MANNONATE
DEHYDRATASE

(Escherichia
coli) 		PF03786
(UxuA) 		3 PRO A 245
LEU A 244
HIS A 196
 None
 0.67A 4pevA-4eayA:
undetectable		 4pevA-4eayA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efh ACTIN-1

(Acanthamoeba
castellanii) 		PF00022
(Actin) 		3 PRO A 109
LEU A 110
HIS A 173
 None
 0.59A 4pevA-4efhA:
undetectable		 4pevA-4efhA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eoc PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE

(Synechocystis
sp. PCC 6803) 		PF05996
(Fe_bilin_red) 		3 PRO A  36
LEU A  35
HIS A 187
 None
CSO  A 188 ( 4.5A)
CSO  A 188 ( 4.7A)
 0.62A 4pevA-4eocA:
undetectable		 4pevA-4eocA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia cuprina) 		PF00135
(COesterase) 		3 PRO A 326
LEU A 325
HIS A 225
 None
 0.65A 4pevA-4fnmA:
3.0		 4pevA-4fnmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn7 ENOLASE

(Agrobacterium
tumefaciens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 PRO A  45
LEU A  48
HIS A  91
 None
 0.73A 4pevA-4jn7A:
undetectable		 4pevA-4jn7A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00814
(Peptidase_M22) 		3 PRO A 119
LEU A 122
HIS A 144
 None
 0.69A 4pevA-4k25A:
undetectable		 4pevA-4k25A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldu AUXIN RESPONSE
FACTOR 5

(Arabidopsis
thaliana) 		PF02362
(B3)
PF06507
(Auxin_resp) 		3 PRO A  67
LEU A  66
HIS A 116
 None
 0.58A 4pevA-4lduA:
undetectable		 4pevA-4lduA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le6 ORGANOPHOSPHORUS
HYDROLASE

(Pseudomonas
pseudoalcaligenes) 		PF00753
(Lactamase_B) 		3 PRO A  58
LEU A  57
HIS A 141
 None
None
ZN  A 405 ( 3.1A)
 0.68A 4pevA-4le6A:
undetectable		 4pevA-4le6A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		3 PRO A 580
LEU A 581
HIS A 561
 None
 0.71A 4pevA-4nh0A:
3.1		 4pevA-4nh0A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh1 CASEIN KINASE II
SUBUNIT BETA

(Homo sapiens) 		PF01214
(CK_II_beta) 		3 PRO C 121
LEU C 120
HIS C 171
 None
 0.72A 4pevA-4nh1C:
undetectable		 4pevA-4nh1C:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk5 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Candidatus
Liberibacter
asiaticus) 		PF13561
(adh_short_C2) 		3 PRO A  51
LEU A  52
HIS A  19
 None
 0.64A 4pevA-4nk5A:
5.7		 4pevA-4nk5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00266
(Aminotran_5) 		3 PRO A 167
LEU A 161
HIS A 389
 None
 0.68A 4pevA-4q76A:
3.8		 4pevA-4q76A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE

(Leishmania
major) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 PRO A 141
LEU A 144
HIS A  43
 None
 0.69A 4pevA-4qg5A:
undetectable		 4pevA-4qg5A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xlt RESPONSE REGULATOR
RECEIVER PROTEIN

(Dyadobacter
fermentans) 		PF00072
(Response_reg) 		3 PRO A  76
LEU A  75
HIS A  41
 None
 0.70A 4pevA-4xltA:
6.6		 4pevA-4xltA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypt REPLICASE
POLYPROTEIN 1AB

(Murine
coronavirus) 		PF08715
(Viral_protease) 		3 PRO A1857
LEU A1856
HIS A1876
 None
 0.51A 4pevA-4yptA:
undetectable		 4pevA-4yptA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		3 PRO A 412
LEU A 411
HIS A 454
 None
 0.66A 4pevA-4zmhA:
3.2		 4pevA-4zmhA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF13654
(AAA_32) 		3 PRO A  85
LEU A  84
HIS A  62
 None
 0.70A 4pevA-4zpxA:
undetectable		 4pevA-4zpxA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbl SURFACE PROTEIN G

(Staphylococcus
aureus) 		PF07501
(G5)
PF17041
(SasG_E) 		3 PRO A 599
LEU A 600
HIS A 506
 None
 0.72A 4pevA-5dblA:
undetectable		 4pevA-5dblA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6

(Mus musculus) 		PF01663
(Phosphodiest) 		3 PRO A 318
LEU A 319
HIS A 288
 None
 0.49A 4pevA-5egeA:
undetectable		 4pevA-5egeA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		3 PRO B 205
LEU B 204
HIS B 213
 SAM  B 401 ( 4.9A)
SAM  B 401 (-4.5A)
None
 0.70A 4pevA-5ergB:
2.6		 4pevA-5ergB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2h UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF02230
(Abhydrolase_2) 		3 PRO A  89
LEU A  90
HIS A  63
 None
 0.63A 4pevA-5f2hA:
5.7		 4pevA-5f2hA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4z EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		3 PRO A 112
LEU A 113
HIS A 196
 None
 0.70A 4pevA-5f4zA:
3.9		 4pevA-5f4zA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fof LEUCYL-TRNA
SYNTHETASE

(Plasmodium
knowlesi) 		no annotation 3 PRO A 435
LEU A 434
HIS A 484
 None
 0.63A 4pevA-5fofA:
undetectable		 4pevA-5fofA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fvd NUCLEOCAPSID

(Human
metapneumovirus) 		PF03246
(Pneumo_ncap) 		3 PRO A 158
LEU A 161
HIS A  56
 None
 0.70A 4pevA-5fvdA:
undetectable		 4pevA-5fvdA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF12436
(USP7_ICP0_bdg) 		3 PRO A 781
LEU A 780
HIS A 792
 None
 0.69A 4pevA-5j7tA:
undetectable		 4pevA-5j7tA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE

(Shewanella
oneidensis) 		PF00465
(Fe-ADH) 		3 PRO A 330
LEU A 331
HIS A 198
 None
 0.60A 4pevA-5k8cA:
5.3		 4pevA-5k8cA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kja APOCAROTENOID-15,15'
-OXYGENASE

(Synechocystis
sp. PCC 6803) 		PF03055
(RPE65) 		3 PRO A 326
LEU A 325
HIS A 238
 None
None
FE2  A 502 (-4.5A)
 0.68A 4pevA-5kjaA:
undetectable		 4pevA-5kjaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Brucella
abortus) 		PF13561
(adh_short_C2) 		3 PRO A  51
LEU A  52
HIS A  19
 None
 0.69A 4pevA-5koiA:
2.7		 4pevA-5koiA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxj L-ASPARTATE OXIDASE

(Salmonella
enterica) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 PRO A 174
LEU A 173
HIS A 196
 None
 0.66A 4pevA-5kxjA:
3.0		 4pevA-5kxjA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0v PROTEIN
O-GLUCOSYLTRANSFERAS
E 1

(Homo sapiens) 		PF05686
(Glyco_transf_90) 		3 PRO A 171
LEU A 181
HIS A 262
 UDP  A1005 ( 4.8A)
UDP  A1005 (-4.8A)
None
 0.71A 4pevA-5l0vA:
3.9		 4pevA-5l0vA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf5 MYELIN-ASSOCIATED
GLYCOPROTEIN

(Mus musculus) 		PF08205
(C2-set_2)
PF13927
(Ig_3) 		3 PRO A 183
LEU A 202
HIS A 213
 None
 0.69A 4pevA-5lf5A:
undetectable		 4pevA-5lf5A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 3 PRO A 311
LEU A 312
HIS A 447
 None
 0.65A 4pevA-5nitA:
3.7		 4pevA-5nitA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE

(Methanothermobacter
marburgensis) 		no annotation 3 PRO A 108
LEU A 107
HIS A 116
 None
 0.64A 4pevA-5ok4A:
2.9		 4pevA-5ok4A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tz6 CURJ

(Moorea
producens) 		PF14765
(PS-DH) 		3 PRO A 973
LEU A 972
HIS A 946
 None
 0.70A 4pevA-5tz6A:
undetectable		 4pevA-5tz6A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2d DIOXYGENASE

(Pseudomonas
brassicacearum) 		no annotation 3 PRO A  35
LEU A  34
HIS A  71
 None
 0.73A 4pevA-5v2dA:
undetectable		 4pevA-5v2dA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfi -

(-) 		no annotation 3 PRO A1857
LEU A1856
HIS A1876
 None
 0.65A 4pevA-5wfiA:
undetectable		 4pevA-5wfiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bms PALMITOYLTRANSFERASE

(Danio rerio) 		no annotation 3 PRO A 102
LEU A 101
HIS A  75
 None
 0.60A 4pevA-6bmsA:
undetectable		 4pevA-6bmsA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3d ARGININOSUCCINATE
LYASE

(Chelativorans
sp. BNC1) 		no annotation 3 PRO A 197
LEU A 198
HIS A 107
 None
 0.60A 4pevA-6g3dA:
undetectable		 4pevA-6g3dA:
13.13