SIMILAR PATTERNS OF AMINO ACIDS FOR 4PD4_C_AOQC4003_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2r PROTEIN
(TRYPTOPHANYL TRNA
SYNTHETASE)


(Geobacillus
stearothermophilus)
PF00579
(tRNA-synt_1b)
5 ILE A 183
ILE A 253
LEU A 248
LEU A 241
ILE A 213
None
1.00A 4pd4C-1d2rA:
undetectable
4pd4C-1d2rA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli)
PF00510
(COX3)
5 GLY C 147
VAL C 150
ILE C 113
LEU C  70
LEU C  77
None
1.08A 4pd4C-1fftC:
3.6
4pd4C-1fftC:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6a HYDROGEN
PEROXIDE-INDUCIBLE
GENES ACTIVATOR


(Escherichia
coli)
PF03466
(LysR_substrate)
5 VAL A 231
ILE A 237
LEU A 257
TYR A 256
LEU A 240
None
1.05A 4pd4C-1i6aA:
undetectable
4pd4C-1i6aA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwa RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E SMALL SUBUNIT


(Galdieria
partita)
PF00101
(RuBisCO_small)
5 GLY B  41
VAL B 101
ILE B  42
PHE B  85
LEU B  84
None
0.94A 4pd4C-1iwaB:
undetectable
4pd4C-1iwaB:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mec MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP1)


(Cardiovirus A)
no annotation 5 GLY 1  44
VAL 1 238
ILE 1  43
PRO 1  66
LEU 1 225
None
1.09A 4pd4C-1mec1:
undetectable
4pd4C-1mec1:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae)
PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N)
5 GLY A 354
ILE A 377
ILE A 296
LEU A 412
ILE A 485
None
1.09A 4pd4C-1n7rA:
0.0
4pd4C-1n7rA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naa CELLOBIOSE
DEHYDROGENASE


(Phanerochaete
chrysosporium)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 GLY A 583
VAL A 608
ILE A 606
LEU A 370
ILE A 659
None
1.07A 4pd4C-1naaA:
undetectable
4pd4C-1naaA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcq PROTEIN (UBIQUITIN
CONJUGATING ENZYME)


(Saccharomyces
cerevisiae)
PF00179
(UQ_con)
5 PHE A  51
ILE A  74
PRO A  41
LEU A 110
ILE A  68
None
0.97A 4pd4C-1qcqA:
undetectable
4pd4C-1qcqA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1u CHOLINE
O-ACETYLTRANSFERASE


(Rattus
norvegicus)
PF00755
(Carn_acyltransf)
5 GLY A 571
ILE A 585
LEU A 431
TYR A 435
LEU A 438
None
0.99A 4pd4C-1t1uA:
undetectable
4pd4C-1t1uA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus)
PF09231
(RDV-p3)
5 PHE A 415
LEU A 455
TYR A 459
LEU A 462
ILE A 438
None
0.95A 4pd4C-1uf2A:
undetectable
4pd4C-1uf2A:
16.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
8 GLY C 158
ILE C 162
ILE C 292
PRO C 294
PHE C 301
TYR C 302
LEU C 305
ILE C 340
SMA  C 503 (-3.3A)
None
SMA  C 503 ( 4.5A)
SMA  C 503 (-4.1A)
SMA  C 503 (-4.7A)
SMA  C 503 (-4.2A)
SMA  C 503 ( 4.6A)
None
0.93A 4pd4C-1zrtC:
48.6
4pd4C-1zrtC:
44.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
8 GLY C 158
ILE C 162
PRO C 294
PHE C 301
TYR C 302
LEU C 305
MET C 336
ILE C 340
SMA  C 503 (-3.3A)
None
SMA  C 503 (-4.1A)
SMA  C 503 (-4.7A)
SMA  C 503 (-4.2A)
SMA  C 503 ( 4.6A)
SMA  C 503 (-3.3A)
None
0.88A 4pd4C-1zrtC:
48.6
4pd4C-1zrtC:
44.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
8 GLY C 158
VAL C 161
ILE C 162
ILE C 292
PHE C 301
TYR C 302
LEU C 305
ILE C 340
SMA  C 503 (-3.3A)
SMA  C 503 (-4.4A)
None
SMA  C 503 ( 4.5A)
SMA  C 503 (-4.7A)
SMA  C 503 (-4.2A)
SMA  C 503 ( 4.6A)
None
0.86A 4pd4C-1zrtC:
48.6
4pd4C-1zrtC:
44.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
8 GLY C 158
VAL C 161
ILE C 162
PHE C 301
TYR C 302
LEU C 305
MET C 336
ILE C 340
SMA  C 503 (-3.3A)
SMA  C 503 (-4.4A)
None
SMA  C 503 (-4.7A)
SMA  C 503 (-4.2A)
SMA  C 503 ( 4.6A)
SMA  C 503 (-3.3A)
None
0.82A 4pd4C-1zrtC:
48.6
4pd4C-1zrtC:
44.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0i DEHYDROGENASE

(Pyrococcus
horikoshii)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 GLY A  38
VAL A  39
ILE A  40
LEU A   8
ILE A  78
None
1.08A 4pd4C-2d0iA:
undetectable
4pd4C-2d0iA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE


(Methanocaldococcus
jannaschii)
PF01409
(tRNA-synt_2d)
5 GLY A 482
ILE A  42
PHE A 380
TYR A 381
ILE A 418
None
0.90A 4pd4C-2du7A:
undetectable
4pd4C-2du7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE


(Methanocaldococcus
jannaschii)
PF01409
(tRNA-synt_2d)
5 GLY A 482
ILE A 484
PHE A 380
TYR A 381
ILE A 418
None
1.07A 4pd4C-2du7A:
undetectable
4pd4C-2du7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY


(Pelobacter
acetylenicus)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
5 GLY A 171
ILE A 170
PRO A 201
LEU A 216
TYR A 218
MGD  A 802 (-3.5A)
MGD  A 802 (-4.7A)
MGD  A 802 (-4.3A)
MGD  A 802 (-4.8A)
MGD  A 802 (-3.9A)
0.94A 4pd4C-2e7zA:
undetectable
4pd4C-2e7zA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis)
PF01274
(Malate_synthase)
5 GLY A 651
VAL A 652
ILE A 653
LEU A 643
ILE A 605
None
1.08A 4pd4C-2gq3A:
2.2
4pd4C-2gq3A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2y UBIQUITIN-CONJUGATIN
G ENZYME


(Plasmodium
falciparum)
PF00179
(UQ_con)
5 GLY A 102
VAL A  98
ILE A 104
TYR A  69
LEU A 130
None
1.05A 4pd4C-2h2yA:
undetectable
4pd4C-2h2yA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi9 PLASMA SERINE
PROTEASE INHIBITOR


(Homo sapiens)
PF00079
(Serpin)
5 VAL A 334
ILE A 289
ILE A 184
PHE A 372
ILE A 249
None
1.07A 4pd4C-2hi9A:
undetectable
4pd4C-2hi9A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivg CYANATE LYASE

(Escherichia
coli)
PF02560
(Cyanate_lyase)
5 PRO A  89
PHE A  97
TYR A  98
LEU A 101
ILE A 144
None
0.98A 4pd4C-2ivgA:
undetectable
4pd4C-2ivgA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3


(Brevibacillus
brevis)
PF00550
(PP-binding)
PF00668
(Condensation)
5 GLY A 481
LEU A 335
TYR A 339
LEU A 342
ILE A 508
None
1.05A 4pd4C-2jgpA:
undetectable
4pd4C-2jgpA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwq UBIQUITIN
CONJUGATING ENZYME


(Plasmodium
yoelii)
PF00179
(UQ_con)
5 PHE A  51
ILE A  74
PRO A  41
LEU A 111
ILE A  68
None
0.97A 4pd4C-2pwqA:
undetectable
4pd4C-2pwqA:
20.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qjp CYTOCHROME B

(Rhodobacter
sphaeroides)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
7 GLY A 158
VAL A 161
ILE A 162
ILE A 292
PRO A 294
MET A 336
ILE A 340
SMA  A   1 (-3.1A)
SMA  A   1 (-4.1A)
SMA  A   1 (-4.5A)
SMA  A   1 ( 4.7A)
SMA  A   1 (-3.8A)
SMA  A   1 (-3.6A)
None
0.85A 4pd4C-2qjpA:
49.8
4pd4C-2qjpA:
45.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qjp CYTOCHROME B

(Rhodobacter
sphaeroides)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
9 GLY A 158
VAL A 161
ILE A 162
PRO A 294
PHE A 301
TYR A 302
LEU A 305
MET A 336
ILE A 340
SMA  A   1 (-3.1A)
SMA  A   1 (-4.1A)
SMA  A   1 (-4.5A)
SMA  A   1 (-3.8A)
None
SMA  A   1 (-4.4A)
SMA  A   1 ( 4.3A)
SMA  A   1 (-3.6A)
None
0.60A 4pd4C-2qjpA:
49.8
4pd4C-2qjpA:
45.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ucz UBIQUITIN
CONJUGATING ENZYME


(Saccharomyces
cerevisiae)
PF00179
(UQ_con)
5 PHE A  54
ILE A  77
PRO A  48
LEU A 127
ILE A  90
None
1.05A 4pd4C-2uczA:
undetectable
4pd4C-2uczA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpp IWS1

(Encephalitozoon
cuniculi)
PF08711
(Med26)
5 GLY A 160
VAL A 159
ILE A 162
ILE A 149
LEU A 141
None
1.05A 4pd4C-2xppA:
undetectable
4pd4C-2xppA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz4 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN LF


(Drosophila
melanogaster)
PF01510
(Amidase_2)
5 GLY A  67
ILE A 101
PHE A 124
TYR A 133
LEU A 125
None
1.00A 4pd4C-2xz4A:
undetectable
4pd4C-2xz4A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT


(Clostridium
scatologenes)
PF01228
(Gly_radical)
PF02901
(PFL-like)
5 GLY A 526
VAL A 225
ILE A 226
PRO A 524
ILE A 327
None
1.06A 4pd4C-2y8nA:
3.3
4pd4C-2y8nA:
18.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yiu CYTOCHROME B

(Paracoccus
denitrificans)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
9 GLY A 158
VAL A 161
ILE A 162
ILE A 292
PRO A 294
PHE A 301
LEU A 305
MET A 336
ILE A 340
SMA  A 502 (-3.5A)
SMA  A 502 (-4.3A)
SMA  A 502 ( 4.5A)
SMA  A 502 (-4.6A)
SMA  A 502 ( 3.8A)
None
SMA  A 502 ( 4.4A)
SMA  A 502 (-3.6A)
None
0.78A 4pd4C-2yiuA:
50.0
4pd4C-2yiuA:
44.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yiu CYTOCHROME B

(Paracoccus
denitrificans)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
9 GLY A 158
VAL A 161
ILE A 162
PRO A 294
PHE A 301
TYR A 302
LEU A 305
MET A 336
ILE A 340
SMA  A 502 (-3.5A)
SMA  A 502 (-4.3A)
SMA  A 502 ( 4.5A)
SMA  A 502 ( 3.8A)
None
SMA  A 502 (-4.5A)
SMA  A 502 ( 4.4A)
SMA  A 502 (-3.6A)
None
0.56A 4pd4C-2yiuA:
50.0
4pd4C-2yiuA:
44.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum)
PF07940
(Hepar_II_III)
PF16332
(DUF4962)
5 VAL A 644
ILE A 643
ILE A 758
PHE A 635
ILE A 506
None
1.05A 4pd4C-3aflA:
2.3
4pd4C-3aflA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c02 AQUAGLYCEROPORIN

(Plasmodium
falciparum)
PF00230
(MIP)
6 GLY A 174
VAL A 173
ILE A 176
LEU A 192
LEU A 149
ILE A 143
None
1.50A 4pd4C-3c02A:
undetectable
4pd4C-3c02A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A)
PF00073
(Rhv)
no annotation
5 GLY A   8
ILE C 206
ILE B  50
LEU B  53
ILE B 214
None
1.09A 4pd4C-3cjiA:
undetectable
4pd4C-3cjiA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpq 50S RIBOSOMAL
PROTEIN L30E


(Methanocaldococcus
jannaschii)
PF01248
(Ribosomal_L7Ae)
5 VAL A   9
ILE A  99
ILE A  71
LEU A  89
ILE A  64
None
1.04A 4pd4C-3cpqA:
undetectable
4pd4C-3cpqA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE


(Cryptosporidium
parvum)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 GLY A  21
VAL A 109
ILE A 108
ILE A  99
LEU A 126
None
0.96A 4pd4C-3cpsA:
undetectable
4pd4C-3cpsA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cql ENDOCHITINASE

(Carica papaya)
PF00182
(Glyco_hydro_19)
5 GLY A  45
ILE A   2
ILE A 172
LEU A 155
LEU A  61
None
1.00A 4pd4C-3cqlA:
undetectable
4pd4C-3cqlA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo8 TAIL SHEATH PROTEIN
GP18


(Escherichia
virus T4)
PF17481
(Phage_sheath_1N)
5 PHE D 334
GLY D 336
ILE D 238
ILE D 254
LEU D 340
None
1.09A 4pd4C-3fo8D:
undetectable
4pd4C-3fo8D:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2


(Schizosaccharomyces
pombe)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
5 PHE B  38
ILE B 190
PRO B 156
LEU B 402
ILE B  49
None
1.07A 4pd4C-3h0gB:
undetectable
4pd4C-3h0gB:
14.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h1l CYTOCHROME B

(Gallus gallus)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
7 GLY C 143
VAL C 146
ILE C 147
ILE C 269
PRO C 271
TYR C 279
LEU C 282
3H1  C2001 (-3.3A)
3H1  C2001 (-4.4A)
3H1  C2001 (-4.7A)
None
3H1  C2001 (-3.8A)
3H1  C2001 (-4.2A)
3H1  C2001 (-4.9A)
0.61A 4pd4C-3h1lC:
52.8
4pd4C-3h1lC:
52.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h1l CYTOCHROME B

(Gallus gallus)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
7 PHE C 129
GLY C 143
VAL C 146
ILE C 147
ILE C 269
PRO C 271
LEU C 282
3H1  C2001 ( 4.7A)
3H1  C2001 (-3.3A)
3H1  C2001 (-4.4A)
3H1  C2001 (-4.7A)
None
3H1  C2001 (-3.8A)
3H1  C2001 (-4.9A)
0.86A 4pd4C-3h1lC:
52.8
4pd4C-3h1lC:
52.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iau THREONINE DEAMINASE

(Solanum
lycopersicum)
PF00291
(PALP)
5 GLY A 196
ILE A 192
PHE A  43
TYR A  45
LEU A  42
None
1.09A 4pd4C-3iauA:
undetectable
4pd4C-3iauA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kaq FLAVODOXIN

(Desulfovibrio
desulfuricans)
PF00258
(Flavodoxin_1)
5 GLY A  56
ILE A   6
LEU A  88
LEU A  46
MET A  81
None
1.02A 4pd4C-3kaqA:
undetectable
4pd4C-3kaqA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzd DPH2

(Pyrococcus
horikoshii)
PF01866
(Diphthamide_syn)
5 PHE A 320
GLY A 187
ILE A 182
LEU A 292
ILE A 222
None
1.01A 4pd4C-3lzdA:
undetectable
4pd4C-3lzdA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5r NONSTRUCTURAL
PROTEIN 1


(Influenza A
virus)
PF00600
(Flu_NS1)
5 GLY A 179
ILE A 182
ILE A 112
LEU A 147
LEU A 119
None
1.05A 4pd4C-3m5rA:
undetectable
4pd4C-3m5rA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 GLY A 569
VAL A 572
ILE A 537
LEU A 532
ILE A 529
None
1.02A 4pd4C-3mosA:
undetectable
4pd4C-3mosA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5f N-CARBAMOYL-L-AMINO
ACID HYDROLASE


(Geobacillus
stearothermophilus)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 GLY A 394
VAL A 397
ILE A 370
LEU A 196
PHE A 348
None
1.08A 4pd4C-3n5fA:
undetectable
4pd4C-3n5fA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odp PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE


(Clostridium
novyi)
PF01380
(SIS)
5 GLY A  72
VAL A  71
ILE A 112
LEU A 188
ILE A 206
None
1.08A 4pd4C-3odpA:
undetectable
4pd4C-3odpA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4


(Saccharomyces
cerevisiae)
PF11701
(UNC45-central)
5 GLY A 391
VAL A 394
ILE A 395
TYR A 355
LEU A 358
None
0.97A 4pd4C-3opbA:
undetectable
4pd4C-3opbA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqq PUTATIVE LIPOPROTEIN

(Bacteroides
ovatus)
PF16129
(DUF4841)
PF16130
(DUF4842)
5 GLY A 215
VAL A 216
ILE A 290
TYR A 175
LEU A 177
None
1.06A 4pd4C-3oqqA:
undetectable
4pd4C-3oqqA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q41 GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
ZETA-1


(Rattus
norvegicus)
PF01094
(ANF_receptor)
5 GLY A 286
VAL A 287
LEU A  91
LEU A 138
ILE A 116
None
1.04A 4pd4C-3q41A:
undetectable
4pd4C-3q41A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4


(Homo sapiens)
PF04130
(Spc97_Spc98)
5 ILE A 613
LEU A 595
PHE A 592
LEU A 588
ILE A 512
None
1.02A 4pd4C-3ripA:
6.1
4pd4C-3ripA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsj BONT/F

(Clostridium
botulinum)
PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N)
6 GLY A1146
VAL A1147
ILE A1116
PHE A1122
LEU A1200
ILE A1197
None
1.38A 4pd4C-3rsjA:
undetectable
4pd4C-3rsjA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1u PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Azotobacter
vinelandii)
PF00160
(Pro_isomerase)
5 PHE A  98
GLY A  52
ILE A  40
LEU A   4
ILE A 162
None
1.10A 4pd4C-3t1uA:
undetectable
4pd4C-3t1uA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t32 AMINOTRANSFERASE,
CLASS I/II


(Bacillus
anthracis)
PF00155
(Aminotran_1_2)
6 PHE A 120
GLY A 353
ILE A 115
LEU A 130
LEU A 110
ILE A  99
None
1.50A 4pd4C-3t32A:
undetectable
4pd4C-3t32A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4y NUCLEAR INHIBITOR OF
PROTEIN PHOSPHATASE
1
SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT


(Homo sapiens)
PF00149
(Metallophos)
PF16891
(STPPase_N)
no annotation
5 GLY A  67
ILE A  65
TYR A  70
LEU A  73
ILE B 210
None
1.04A 4pd4C-3v4yA:
undetectable
4pd4C-3v4yA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrk CARBONYL SULFIDE
HYDROLASE


(Thiobacillus
thioparus)
PF00484
(Pro_CA)
5 GLY A 196
ILE A  93
ILE A 198
LEU A  10
LEU A  54
None
1.02A 4pd4C-3vrkA:
undetectable
4pd4C-3vrkA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3we5 UBIQUITIN
CONJUGATING ENZYME


(Agrocybe
aegerita)
PF00179
(UQ_con)
5 GLY A  90
VAL A  86
ILE A  92
LEU A  55
TYR A  53
None
1.00A 4pd4C-3we5A:
undetectable
4pd4C-3we5A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3we5 UBIQUITIN
CONJUGATING ENZYME


(Agrocybe
aegerita)
PF00179
(UQ_con)
5 GLY A  90
VAL A  86
ILE A  92
TYR A  53
LEU A 118
None
1.00A 4pd4C-3we5A:
undetectable
4pd4C-3we5A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A 188
ILE A 262
LEU A 110
PHE A 107
ILE A 292
None
1.03A 4pd4C-3zduA:
undetectable
4pd4C-3zduA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a39 METALLO-CARBOXYPEPTI
DASE


(Pseudomonas
aeruginosa)
PF00246
(Peptidase_M14)
5 GLY A 360
VAL A 363
ILE A 259
LEU A 203
LEU A 255
None
1.01A 4pd4C-4a39A:
undetectable
4pd4C-4a39A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN


(Arabidopsis
thaliana)
PF16035
(Chalcone_2)
5 VAL A  54
ILE A  85
ILE A  70
LEU A  25
ILE A  89
None
1.09A 4pd4C-4dooA:
undetectable
4pd4C-4dooA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4u MANDALATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(unidentified)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 PHE A  25
GLY A 313
ILE A 351
LEU A 370
LEU A 366
None
0.98A 4pd4C-4e4uA:
undetectable
4pd4C-4e4uA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5t MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN


(Labrenzia
alexandrii)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 PHE A  25
GLY A 319
ILE A 357
LEU A 376
LEU A 372
None
1.07A 4pd4C-4e5tA:
undetectable
4pd4C-4e5tA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae)
PF01274
(Malate_synthase)
5 GLY A 656
VAL A 657
ILE A 658
LEU A 648
ILE A 610
None
1.07A 4pd4C-4ex4A:
undetectable
4pd4C-4ex4A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fb5 PROBABLE
OXIDOREDUCTASE
PROTEIN


(Rhizobium etli)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 GLY A   5
VAL A  75
ILE A   6
LEU A 331
ILE A 325
None
1.08A 4pd4C-4fb5A:
undetectable
4pd4C-4fb5A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)


(Mycobacteroides
abscessus)
PF00202
(Aminotran_3)
5 PHE A  62
ILE A  14
PRO A  43
LEU A 402
ILE A 441
None
1.02A 4pd4C-4ffcA:
undetectable
4pd4C-4ffcA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fm9 DNA TOPOISOMERASE
2-ALPHA


(Homo sapiens)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C)
5 PHE A 569
GLY A 534
ILE A 536
LEU A 516
ILE A 507
None
1.07A 4pd4C-4fm9A:
undetectable
4pd4C-4fm9A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III


(Scadoxus
multiflorus)
PF00704
(Glyco_hydro_18)
5 PHE A  38
GLY A  75
ILE A  74
LEU A  83
ILE A 138
None
1.00A 4pd4C-4n42A:
undetectable
4pd4C-4n42A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npk EXTENDED
SYNAPTOTAGMIN-2


(Homo sapiens)
PF00168
(C2)
5 PHE A 391
GLY A 416
ILE A 418
LEU A 499
PHE A 489
None
0.96A 4pd4C-4npkA:
undetectable
4pd4C-4npkA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p42 EXTENDED
SYNAPTOTAGMIN-2


(Homo sapiens)
PF00168
(C2)
PF17047
(SMP_LBD)
5 PHE A 363
GLY A 388
ILE A 390
LEU A 471
PHE A 461
None
0.95A 4pd4C-4p42A:
undetectable
4pd4C-4p42A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0m MCYG PROTEIN

(Microcystis
aeruginosa)
no annotation 5 GLY B 234
VAL B 238
ILE B 235
ILE B  34
LEU B  87
None
0.96A 4pd4C-4r0mB:
undetectable
4pd4C-4r0mB:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rml LATROPHILIN-3

(Mus musculus)
PF02191
(OLF)
5 VAL A 391
ILE A 407
PRO A 426
TYR A 455
LEU A 444
None
1.01A 4pd4C-4rmlA:
undetectable
4pd4C-4rmlA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN


(Helicobacter
pylori)
PF01551
(Peptidase_M23)
5 GLY A 355
ILE A 357
ILE A 351
LEU A 302
ILE A 272
None
1.07A 4pd4C-4rnzA:
undetectable
4pd4C-4rnzA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN


(Burkholderia
pseudomallei)
PF06429
(Flg_bbr_C)
5 PHE A 554
GLY A 456
ILE A 458
LEU A 485
ILE A 525
None
0.98A 4pd4C-4ut1A:
0.0
4pd4C-4ut1A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yep LAMININ SUBUNIT
ALPHA-2


(Homo sapiens)
PF00052
(Laminin_B)
5 GLY A1278
ILE A1276
PHE A1241
MET A1359
ILE A1357
None
None
None
None
EDO  A1409 ( 2.5A)
1.05A 4pd4C-4yepA:
undetectable
4pd4C-4yepA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeq LAMININ SUBUNIT
ALPHA-2


(Homo sapiens)
PF00052
(Laminin_B)
5 GLY U 103
ILE U 101
PHE U  66
MET U 184
ILE U 182
None
0.98A 4pd4C-4yeqU:
undetectable
4pd4C-4yeqU:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR


(Streptobacillus
moniliformis)
PF13407
(Peripla_BP_4)
5 GLY A  98
VAL A 101
ILE A 102
LEU A  88
ILE A 296
None
1.02A 4pd4C-4z0nA:
undetectable
4pd4C-4z0nA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq9 UNCHARACTERIZED
PROTEIN


(Legionella
pneumophila)
PF12252
(SidE)
6 PHE A  44
GLY A  67
ILE A  56
LEU A  85
PHE A  88
LEU A  90
None
1.49A 4pd4C-5bq9A:
undetectable
4pd4C-5bq9A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btx LPG1496

(Legionella
pneumophila)
no annotation 6 PHE A  44
GLY A  67
ILE A  56
LEU A  85
PHE A  88
LEU A  90
None
1.39A 4pd4C-5btxA:
undetectable
4pd4C-5btxA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN


([Candida]
glabrata)
PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central)
5 GLY A1091
ILE A1143
LEU A1516
PHE A1519
TYR A1520
None
1.01A 4pd4C-5d0fA:
undetectable
4pd4C-5d0fA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dnw SHKAI2IB

(Striga
hermonthica)
PF12697
(Abhydrolase_6)
5 PHE A  91
GLY A  23
LEU A  77
TYR A  73
LEU A  70
None
1.05A 4pd4C-5dnwA:
undetectable
4pd4C-5dnwA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3t PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE I,
ALPHA


(Danio rerio)
PF01504
(PIP5K)
5 PHE A 131
ILE A 379
LEU A 192
PHE A 189
LEU A 185
None
0.92A 4pd4C-5e3tA:
undetectable
4pd4C-5e3tA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwj DNA TOPOISOMERASE
2-BETA


(Homo sapiens)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C)
5 PHE A 585
GLY A 550
ILE A 552
LEU A 532
ILE A 523
None
0.99A 4pd4C-5gwjA:
2.1
4pd4C-5gwjA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192


(Chaetomium
thermophilum)
PF11894
(Nup192)
5 GLY B1198
ILE B1200
ILE B1213
LEU B1124
ILE B1075
None
1.06A 4pd4C-5hb4B:
undetectable
4pd4C-5hb4B:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE


(Saccharomyces
cerevisiae)
PF00067
(p450)
5 GLY A 108
VAL A 112
PRO A 410
LEU A 461
ILE A 452
None
1.05A 4pd4C-5hs1A:
undetectable
4pd4C-5hs1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j57 VHH SINGLE CHAIN
ANTIBODY V5E1


(Vicugna pacos)
PF07686
(V-set)
5 GLY B 114
VAL B 115
TYR B  32
LEU B  29
ILE B  70
None
1.05A 4pd4C-5j57B:
undetectable
4pd4C-5j57B:
15.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nmi CYTOCHROME B

(Bos taurus)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
6 PHE C 128
GLY C 142
ILE C 268
TYR C 278
LEU C 281
ILE C 298
None
1.24A 4pd4C-5nmiC:
51.6
4pd4C-5nmiC:
50.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN


(Rhodobacter
sphaeroides)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
6 PHE A 201
GLY A 239
VAL A 265
ILE A 266
LEU A 171
ILE A 157
None
1.44A 4pd4C-5nv3A:
undetectable
4pd4C-5nv3A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL


(Homo sapiens)
PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C)
5 ILE A 903
ILE A 911
PRO A 877
LEU A 601
ILE A 579
None
0.97A 4pd4C-5o1pA:
undetectable
4pd4C-5o1pA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE


(Saccharum
hybrid cultivar)
no annotation 5 GLY A 355
VAL A  65
ILE A 356
LEU A 243
ILE A 237
None
1.08A 4pd4C-5wegA:
undetectable
4pd4C-5wegA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xru ADENYLATE KINASE

(Notothenia
coriiceps)
no annotation 5 GLY A  94
ILE A  92
LEU A  42
LEU A  73
ILE A  81
AP5  A 201 (-4.4A)
None
None
None
None
1.06A 4pd4C-5xruA:
undetectable
4pd4C-5xruA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axe MALATE SYNTHASE G

(Mycobacterium
marinum)
PF01274
(Malate_synthase)
5 GLY A 655
VAL A 656
ILE A 657
LEU A 647
ILE A 609
None
1.06A 4pd4C-6axeA:
undetectable
4pd4C-6axeA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)


(Homo sapiens)
no annotation 5 PHE A1872
GLY A2023
ILE A2074
LEU A1949
ILE A1972
None
0.84A 4pd4C-6bq1A:
1.7
4pd4C-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfp VCA0883

(Vibrio cholerae)
no annotation 5 GLY A 227
VAL A 211
ILE A 186
MET A 175
ILE A 172
None
1.04A 4pd4C-6dfpA:
undetectable
4pd4C-6dfpA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egx STRUCTURAL PROTEIN
VP1


(Sacbrood virus)
no annotation 5 ILE A  58
ILE A 144
LEU A  49
MET A 209
ILE A 106
None
1.06A 4pd4C-6egxA:
undetectable
4pd4C-6egxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE EPSILON
CHAIN, CHLOROPLASTIC


(Spinacia
oleracea)
no annotation 5 GLY e  65
VAL e  78
ILE e  46
LEU e  24
LEU e  60
None
1.06A 4pd4C-6fkhe:
undetectable
4pd4C-6fkhe:
11.95