SIMILAR PATTERNS OF AMINO ACIDS FOR 4PCU_A_SAMA603_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brt BROMOPEROXIDASE A2

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		4 PHE A  61
ASP A  57
PRO A  67
ILE A  29
 None
 0.95A 4pcuA-1brtA:
3.4		 4pcuA-1brtA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clw TAILSPIKE PROTEIN

(Salmonella
virus P22) 		PF09251
(PhageP22-tail) 		4 PHE A 160
ASP A 159
GLN A 134
ILE A 180
 None
 1.08A 4pcuA-1clwA:
undetectable		 4pcuA-1clwA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqq S3-RNASE

(Pyrus pyrifolia) 		PF00445
(Ribonuclease_T2) 		4 ASP A  27
GLN A  11
THR A  31
ILE A  67
 None
 1.07A 4pcuA-1iqqA:
undetectable		 4pcuA-1iqqA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m76 3-HYDROXYACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 PHE A 154
THR A 174
ILE A 172
ASP A 201
 None
 0.94A 4pcuA-1m76A:
2.8		 4pcuA-1m76A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 PHE A1150
GLN A 957
THR A 953
ASP A 886
 None
 1.06A 4pcuA-1n5xA:
undetectable		 4pcuA-1n5xA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8t APOLIPOPROTEIN C-II

(Homo sapiens) 		PF05355
(Apo-CII) 		4 ASP A   7
GLN A   5
PRO A   4
THR A  13
 None
 1.00A 4pcuA-1o8tA:
undetectable		 4pcuA-1o8tA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oz9 HYPOTHETICAL PROTEIN
AQ_1354

(Aquifex
aeolicus) 		PF02130
(UPF0054) 		4 GLN A  97
THR A  93
ILE A  53
ASP A  50
 None
 1.01A 4pcuA-1oz9A:
undetectable		 4pcuA-1oz9A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re0 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 1

(Saccharomyces
cerevisiae) 		PF01369
(Sec7) 		4 ASP B 215
GLN B 216
PRO B 246
ILE B 187
 None
 1.04A 4pcuA-1re0B:
undetectable		 4pcuA-1re0B:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		4 PHE A   4
ASP A   2
PRO A  14
ILE A  70
 None
 1.05A 4pcuA-1yw6A:
1.6		 4pcuA-1yw6A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzw GFP-LIKE
NON-FLUORESCENT
CHROMOPROTEIN

(Heteractis
crispa) 		PF01353
(GFP) 		4 PHE A  81
PRO A 190
THR A 195
ILE A 197
 None
None
None
CRU  A  64 ( 4.5A)
 1.05A 4pcuA-1yzwA:
undetectable		 4pcuA-1yzwA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)

(Black beetle
virus) 		PF01829
(Peptidase_A6) 		4 PHE A 140
PRO A 275
THR A 296
ILE A 115
 None
 0.98A 4pcuA-2bbvA:
undetectable		 4pcuA-2bbvA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 GLN A 517
PRO A 515
ILE A  98
ASP A  53
 FAD  A 525 (-3.9A)
None
None
None
 1.04A 4pcuA-2exrA:
undetectable		 4pcuA-2exrA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 260
GLN A 451
PRO A 134
ILE A 454
 None
None
CIT  A 701 (-4.4A)
None
 0.97A 4pcuA-2fqdA:
undetectable		 4pcuA-2fqdA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 471
GLN A 451
PRO A 134
ILE A 454
 None
None
CIT  A 701 (-4.4A)
None
 0.99A 4pcuA-2fqdA:
undetectable		 4pcuA-2fqdA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		PF00076
(RRM_1) 		4 PRO A 234
THR A 313
ILE A 317
ASP A 314
 None
 0.61A 4pcuA-2g4bA:
undetectable		 4pcuA-2g4bA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 PHE A 628
ASP A 592
PRO A 625
ILE A 589
 None
 0.98A 4pcuA-2hnhA:
undetectable		 4pcuA-2hnhA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz7 GLUTAMINYL-TRNA
SYNTHETASE

(Deinococcus
radiodurans) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 PHE A 451
ASP A 450
PRO A 455
ILE A 476
 None
 1.01A 4pcuA-2hz7A:
3.2		 4pcuA-2hz7A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 PHE A 343
ASP A 344
THR A 306
ASP A 304
 None
 1.01A 4pcuA-2okxA:
undetectable		 4pcuA-2okxA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9m HYPOTHETICAL PROTEIN
MJ0922

(Methanocaldococcus
jannaschii) 		PF00571
(CBS) 		4 ASP A 127
GLN A 111
PRO A 113
ASP A  59
 None
 1.08A 4pcuA-2p9mA:
15.0		 4pcuA-2p9mA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pm9 PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 ASP A 234
GLN A 210
THR A 229
ILE A 237
 None
 1.05A 4pcuA-2pm9A:
undetectable		 4pcuA-2pm9A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 ASP A 853
GLN A 832
THR A 857
ILE A 515
 None
 1.05A 4pcuA-2r6fA:
undetectable		 4pcuA-2r6fA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbg PUTATIVE
UNCHARACTERIZED
PROTEIN ST0493

(Sulfurisphaera
tokodaii) 		no annotation 4 PHE A  25
ASP A  27
THR A   8
ILE A  10
 None
 0.79A 4pcuA-2rbgA:
2.3		 4pcuA-2rbgA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		4 ASP A 582
GLN A 507
PRO A 505
ILE A 618
 None
 1.02A 4pcuA-2rdyA:
undetectable		 4pcuA-2rdyA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgf RALGEF-RBD

(Homo sapiens) 		PF00788
(RA) 		4 PHE A  91
ASP A  90
GLN A  63
ILE A  14
 None
 0.91A 4pcuA-2rgfA:
undetectable		 4pcuA-2rgfA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0s LR1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 ASP A 145
GLN A  42
THR A  12
ILE A 231
 GOL  A1240 (-2.7A)
None
None
None
 0.92A 4pcuA-2v0sA:
undetectable		 4pcuA-2v0sA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0s LR1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 PHE A 146
ASP A 145
THR A  12
ILE A 231
 None
GOL  A1240 (-2.7A)
None
None
 0.96A 4pcuA-2v0sA:
undetectable		 4pcuA-2v0sA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z87 CHONDROITIN SYNTHASE

(Escherichia
coli) 		PF00535
(Glycos_transf_2) 		4 PRO A 432
THR A  67
ILE A  63
ASP A  64
 None
 1.03A 4pcuA-2z87A:
3.1		 4pcuA-2z87A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		4 PHE A 860
GLN A 864
THR A 874
ILE A 878
 None
 0.94A 4pcuA-3aibA:
2.3		 4pcuA-3aibA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmb REGULATOR OF
NUCLEOSIDE
DIPHOSPHATE KINASE

(Escherichia
coli) 		PF01272
(GreA_GreB)
PF14760
(Rnk_N) 		4 GLN A 127
THR A  55
ILE A   8
ASP A  12
 None
 1.08A 4pcuA-3bmbA:
undetectable		 4pcuA-3bmbA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt6 INFLUENZA B
HEMAGGLUTININ (HA)
INFLUENZA B
HEMAGGLUTININ (HA)

(Influenza B
virus;
Influenza B
virus) 		PF00509
(Hemagglutinin)
PF00509
(Hemagglutinin) 		4 ASP B  71
GLN A 106
PRO A 108
ASP A 100
 None
 1.04A 4pcuA-3bt6B:
undetectable		 4pcuA-3bt6B:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddj CBS
DOMAIN-CONTAINING
PROTEIN

(Sulfolobus
solfataricus) 		PF00571
(CBS) 		4 PHE A 168
PRO A 172
THR A 256
ASP A 259
 AMP  A 278 (-3.5A)
AMP  A 278 (-4.7A)
AMP  A 278 (-3.1A)
AMP  A 278 (-2.7A)
 0.83A 4pcuA-3ddjA:
10.7		 4pcuA-3ddjA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fob BROMOPEROXIDASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		4 PHE A  62
ASP A  58
PRO A  68
ILE A  30
 None
 1.00A 4pcuA-3fobA:
undetectable		 4pcuA-3fobA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 PRO A 488
THR A 160
ILE A 158
ASP A 159
 None
 1.05A 4pcuA-3gwjA:
undetectable		 4pcuA-3gwjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		4 PHE A  57
ASP A  53
PRO A  63
ASP A  99
 None
 0.84A 4pcuA-3heaA:
undetectable		 4pcuA-3heaA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh5 PROTEIN MJ1225

(Methanocaldococcus
jannaschii) 		PF00571
(CBS) 		4 PHE A 179
PRO A 183
THR A 271
ASP A 274
 ADP  A 284 (-3.4A)
None
ADP  A 284 (-3.4A)
ADP  A 284 (-2.8A)
 0.82A 4pcuA-3kh5A:
10.4		 4pcuA-3kh5A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkj AMINE OXIDASE,
FLAVIN-CONTAINING

(Pseudomonas
syringae group
genomosp. 3) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 PHE A  31
ASP A  32
PRO A 121
ILE A 156
 None
FAD  A 401 (-2.9A)
None
None
 0.79A 4pcuA-3kkjA:
2.8		 4pcuA-3kkjA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5u PHOSPHOSERINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00266
(Aminotran_5) 		4 PHE A 126
ASP A 127
THR A 152
ILE A 129
 None
 0.82A 4pcuA-3m5uA:
undetectable		 4pcuA-3m5uA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mez MANNOSE-SPECIFIC
LECTIN 3 CHAIN 1
MANNOSE-SPECIFIC
LECTIN 3 CHAIN 2

(Crocus vernus;
Crocus vernus) 		PF01453
(B_lectin)
PF01453
(B_lectin) 		4 ASP B  25
THR B  23
ILE B  97
ASP A   1
 None
None
FMT  B 115 ( 4.2A)
None
 1.02A 4pcuA-3mezB:
undetectable		 4pcuA-3mezB:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqz UNCHARACTERIZED
CONSERVED PROTEIN
DUF1054

(Leptospirillum
rubarum) 		PF06335
(DUF1054) 		4 PHE A 187
ASP A 188
GLN A  10
ILE A 194
 None
 0.95A 4pcuA-3mqzA:
undetectable		 4pcuA-3mqzA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv0 NUCLEAR RNA EXPORT
FACTOR 2

(Caenorhabditis
elegans) 		no annotation 4 PHE A 359
THR A 313
ILE A 314
ASP A 228
 None
None
None
NA  A 455 ( 3.5A)
 0.85A 4pcuA-3nv0A:
undetectable		 4pcuA-3nv0A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0h GLUTATHIONE
REDUCTASE

(Bartonella
henselae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 PHE A   4
ASP A   5
THR A 122
ASP A 119
 None
 0.96A 4pcuA-3o0hA:
2.8		 4pcuA-3o0hA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocm PUTATIVE MEMBRANE
PROTEIN

(Bordetella
parapertussis) 		PF00571
(CBS) 		4 PRO A 369
THR A 443
ILE A 445
ASP A 446
 None
ADP  A 470 (-3.0A)
ADP  A 470 (-4.1A)
ADP  A 470 (-2.8A)
 0.54A 4pcuA-3ocmA:
10.1		 4pcuA-3ocmA:
16.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pc3 CG1753, ISOFORM A

(Drosophila
melanogaster) 		PF00291
(PALP)
PF00571
(CBS) 		4 ASP A 412
GLN A 413
PRO A 415
THR A 496
 None
 0.58A 4pcuA-3pc3A:
55.2		 4pcuA-3pc3A:
50.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pc3 CG1753, ISOFORM A

(Drosophila
melanogaster) 		PF00291
(PALP)
PF00571
(CBS) 		4 ASP A 412
GLN A 413
THR A 496
ASP A 499
 None
 0.62A 4pcuA-3pc3A:
55.2		 4pcuA-3pc3A:
50.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q33 HISTONE
ACETYLTRANSFERASE
RTT109

(Saccharomyces
cerevisiae) 		PF08214
(HAT_KAT11) 		4 GLN A  23
PRO A 352
THR A  49
ILE A  47
 None
 0.97A 4pcuA-3q33A:
undetectable		 4pcuA-3q33A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrc DUFFY RECEPTOR

(Plasmodium
vivax) 		PF03011
(PFEMP)
PF05424
(Duffy_binding) 		4 ASP A 318
GLN A 388
PRO A 387
ASP A 235
 EDO  A   3 (-4.6A)
None
None
None
 1.08A 4pcuA-3rrcA:
undetectable		 4pcuA-3rrcA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		5 ASP A 300
PRO A 407
THR A 509
ILE A 506
ASP A 508
 None
 1.32A 4pcuA-3s1sA:
4.6		 4pcuA-3s1sA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 PHE A 117
THR A 503
ILE A 450
ASP A 449
 None
 0.97A 4pcuA-3s29A:
undetectable		 4pcuA-3s29A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teb ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE

(Leptotrichia
buccalis) 		PF03372
(Exo_endo_phos) 		4 ASP A 173
GLN A  38
THR A   5
ILE A 257
 None
 0.91A 4pcuA-3tebA:
undetectable		 4pcuA-3tebA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teb ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE

(Leptotrichia
buccalis) 		PF03372
(Exo_endo_phos) 		4 PHE A 174
ASP A 173
THR A   5
ILE A 257
 None
 1.09A 4pcuA-3tebA:
undetectable		 4pcuA-3tebA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty1 HYPOTHETICAL ALDOSE
1-EPIMERASE

(Klebsiella
pneumoniae) 		PF14486
(DUF4432) 		4 PHE A 363
ASP A 364
GLN A 312
PRO A 314
 None
None
SO4  A 511 (-3.9A)
None
 1.07A 4pcuA-3ty1A:
undetectable		 4pcuA-3ty1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ASP A 836
PRO A1229
THR A 751
ILE A 831
 None
 1.07A 4pcuA-3zyvA:
undetectable		 4pcuA-3zyvA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzk PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12931
(Sec16_C) 		4 ASP A 234
GLN A 210
THR A 229
ILE A 237
 None
 1.05A 4pcuA-4bzkA:
undetectable		 4pcuA-4bzkA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN

(Pyrococcus sp.
ST04) 		no annotation 4 ASP A 331
PRO A 116
THR A 157
ASP A 159
 None
 1.09A 4pcuA-4cmrA:
undetectable		 4pcuA-4cmrA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN

(Pyrococcus sp.
ST04) 		no annotation 4 ASP A 331
PRO A 152
THR A 157
ASP A 159
 None
 1.09A 4pcuA-4cmrA:
undetectable		 4pcuA-4cmrA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ea1 DEHYDROSQUALENE
SYNTHASE

(Staphylococcus
aureus) 		PF00494
(SQS_PSY) 		4 PHE A  59
GLN A  58
ILE A  51
ASP A  52
 None
 0.93A 4pcuA-4ea1A:
undetectable		 4pcuA-4ea1A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4w DNA POLYMERASE IV

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		4 PHE A  11
ASP A   9
GLN A  14
ILE A 133
 None
 0.97A 4pcuA-4f4wA:
undetectable		 4pcuA-4f4wA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		4 ASP W 341
PRO W 576
THR W 459
ASP W 453
 None
 1.07A 4pcuA-4f5xW:
undetectable		 4pcuA-4f5xW:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe9 OUTER MEMBRANE
PROTEIN SUSF

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE)
PF17142
(DUF5115) 		4 PHE A 174
ASP A 173
THR A 250
ILE A 248
 None
GLC  A 502 ( 2.6A)
None
None
 1.02A 4pcuA-4fe9A:
undetectable		 4pcuA-4fe9A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flc ADENYLOSUCCINATE
LYASE

(Homo sapiens) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 PHE A  36
THR A 119
ILE A 123
ASP A 120
 None
 0.80A 4pcuA-4flcA:
undetectable		 4pcuA-4flcA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 4 GLN A 609
THR A 448
ILE A 452
ASP A 449
 None
 1.01A 4pcuA-4fyeA:
4.0		 4pcuA-4fyeA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PHE A 370
ASP A 367
THR A 223
ILE A 224
 None
 0.94A 4pcuA-4g1pA:
2.1		 4pcuA-4g1pA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyk DNA POLYMERASE IV

(Sulfolobus
acidocaldarius) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		4 PHE A  11
ASP A   9
GLN A  14
ILE A 133
 None
 0.98A 4pcuA-4hykA:
undetectable		 4pcuA-4hykA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Kitasatospora
aureofaciens;
Influenza A
virus) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		4 PHE A  61
ASP A  57
PRO A  67
ILE A  29
 None
 1.02A 4pcuA-4iq4A:
undetectable		 4pcuA-4iq4A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus) 		PF02128
(Peptidase_M36) 		4 PHE A 464
ASP A 463
THR A 432
ILE A 428
 None
 1.03A 4pcuA-4k90A:
undetectable		 4pcuA-4k90A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		4 GLN A 127
THR A 119
ILE A 117
ASP A 118
 None
 0.98A 4pcuA-4kpnA:
undetectable		 4pcuA-4kpnA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Conexibacter
woesei) 		PF13407
(Peripla_BP_4) 		4 PHE A 153
GLN A 189
THR A 265
ASP A 266
 GOL  A 502 ( 4.7A)
None
None
GOL  A 502 ( 4.3A)
 1.04A 4pcuA-4kq9A:
2.6		 4pcuA-4kq9A:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l27 CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		no annotation 4 PRO B 447
THR B 535
ILE B 537
ASP B 538
 None
 0.80A 4pcuA-4l27B:
58.0		 4pcuA-4l27B:
98.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3s DNA POLYMERASE ETA

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		4 PHE A  17
ASP A  15
GLN A  20
ILE A 204
 None
0KX  A 501 (-4.8A)
None
None
 0.98A 4pcuA-4o3sA:
undetectable		 4pcuA-4o3sA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qan HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus) 		no annotation 4 ASP A 105
PRO A  99
THR A 211
ASP A 212
 None
 0.86A 4pcuA-4qanA:
undetectable		 4pcuA-4qanA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides) 		PF02324
(Glyco_hydro_70) 		4 PHE A2594
GLN A2598
THR A2608
ILE A2612
 None
 0.96A 4pcuA-4tvcA:
undetectable		 4pcuA-4tvcA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u13 PUTATIVE POLYKETIDE
CYCLASE SMA1630

(Sinorhizobium
meliloti) 		PF12680
(SnoaL_2) 		4 PHE A  11
ASP A  12
THR A  25
ILE A   6
 None
 0.97A 4pcuA-4u13A:
undetectable		 4pcuA-4u13A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uj6 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		4 PHE A 110
THR A 123
ILE A 125
ASP A 126
 None
 1.03A 4pcuA-4uj6A:
undetectable		 4pcuA-4uj6A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uom FAB FRAGMENT HEAVY
CHAIN
FAB FRAGMENT LIGHT
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 PHE H 103
ASP H 104
PRO L  45
ILE H  34
 None
 1.03A 4pcuA-4uomH:
undetectable		 4pcuA-4uomH:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuu CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00571
(CBS) 		7 PHE A 443
ASP A 444
GLN A 445
PRO A 447
THR A 535
ILE A 537
ASP A 538
 SAM  A1546 (-3.5A)
SAM  A1546 ( 3.2A)
SAM  A1546 (-3.0A)
None
SAM  A1546 (-2.9A)
None
SAM  A1546 ( 2.9A)
 0.36A 4pcuA-4uuuA:
3.0		 4pcuA-4uuuA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3d HB3VAR03 CIDRA
DOMAIN

(Plasmodium
falciparum) 		PF03011
(PFEMP) 		4 PHE A 577
ASP A 576
ILE A 584
ASP A 585
 None
 0.87A 4pcuA-4v3dA:
undetectable		 4pcuA-4v3dA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3e IT4VAR07 CIDRA

(Plasmodium
falciparum) 		PF03011
(PFEMP) 		4 PHE A 574
ASP A 573
ILE A 581
ASP A 582
 None
 0.87A 4pcuA-4v3eA:
undetectable		 4pcuA-4v3eA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfl 1B2530 HEAVY CHAIN
1B2530 LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 PHE H 112
ASP H 113
PRO L  44
ILE H  33
 None
 0.74A 4pcuA-4yflH:
undetectable		 4pcuA-4yflH:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 PHE A  28
THR A  33
ILE A  72
ASP A  68
 None
 1.08A 4pcuA-4zo6A:
undetectable		 4pcuA-4zo6A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN

(Homo sapiens) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 PHE A  57
ASP A  58
THR A  89
ILE A  88
 None
 1.09A 4pcuA-4ztdA:
undetectable		 4pcuA-4ztdA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE

(Thermus
thermophilus) 		PF00571
(CBS) 		4 PHE A  32
PRO A  36
THR A 122
ASP A 125
 None
 0.75A 4pcuA-5aweA:
9.9		 4pcuA-5aweA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnz GLUTAMINE--TRNA
LIGASE

(Pseudomonas
aeruginosa) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 PHE A 394
ASP A 393
PRO A 398
ILE A 419
 None
 1.04A 4pcuA-5bnzA:
2.4		 4pcuA-5bnzA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gne LEUCINE
AMINOPEPTIDASE

(Legionella
pneumophila) 		PF04389
(Peptidase_M28) 		4 ASP A 339
GLN A 286
PRO A 353
ILE A 214
 None
 1.04A 4pcuA-5gneA:
undetectable		 4pcuA-5gneA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 ASP A  64
PRO A1149
ILE A  68
ASP A  90
 None
 1.04A 4pcuA-5hy7A:
undetectable		 4pcuA-5hy7A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		4 ASP A 183
PRO A 217
THR A 367
ASP A 370
 None
 1.06A 4pcuA-5i92A:
undetectable		 4pcuA-5i92A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j98 VP2
VP3

(Slow bee
paralysis
virus;
Slow bee
paralysis virus) 		PF00073
(Rhv)
PF00073
(Rhv) 		4 PRO B 153
THR C 231
ILE C 229
ASP C  69
 None
 1.04A 4pcuA-5j98B:
undetectable		 4pcuA-5j98B:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 GLN A 620
PRO A 399
THR A 395
ILE A  75
 None
 1.04A 4pcuA-5jouA:
2.9		 4pcuA-5jouA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5x DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA135

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF06883
(RNA_pol_Rpa2_4) 		4 ASP B 946
PRO B 932
ILE B 949
ASP B 782
 None
 1.04A 4pcuA-5m5xB:
undetectable		 4pcuA-5m5xB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 PHE T1782
GLN T1779
THR T1810
ILE T1807
 None
 1.08A 4pcuA-5ojsT:
undetectable		 4pcuA-5ojsT:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT

(Homo sapiens) 		no annotation 4 PHE G 114
ASP G 115
PRO G 185
ILE G  34
 None
 0.89A 4pcuA-5u0uG:
undetectable		 4pcuA-5u0uG:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8z CAROTENOID OXYGENASE
1

(Neurospora
crassa) 		PF03055
(RPE65) 		4 PHE A 185
ASP A 186
GLN A 188
PRO A 190
 None
 0.78A 4pcuA-5u8zA:
undetectable		 4pcuA-5u8zA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE

(Haemophilus
influenzae) 		PF02219
(MTHFR) 		4 PRO A  29
THR A  88
ILE A  90
ASP A  91
 None
FAD  A 300 ( 4.3A)
None
None
 0.99A 4pcuA-5umeA:
2.4		 4pcuA-5umeA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umf RIBULOSE-PHOSPHATE
3-EPIMERASE

(Neisseria
gonorrhoeae) 		PF00834
(Ribul_P_3_epim) 		4 PRO A  63
THR A 198
ILE A 177
ASP A 197
 None
 0.81A 4pcuA-5umfA:
2.4		 4pcuA-5umfA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR

(Escherichia
coli;
Homo sapiens) 		no annotation 4 PHE A2095
ASP A2090
THR A2037
ILE A2041
 None
 1.06A 4pcuA-5v6yA:
undetectable		 4pcuA-5v6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2o TASTE RECEPTOR, TYPE
1, MEMBER 3

(Oryzias latipes) 		PF01094
(ANF_receptor) 		4 ASP B  71
THR B 382
ILE B 324
ASP B 325
 None
 0.98A 4pcuA-5x2oB:
undetectable		 4pcuA-5x2oB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2o TASTE RECEPTOR, TYPE
1, MEMBER 3

(Oryzias latipes) 		PF01094
(ANF_receptor) 		4 PRO B  45
THR B 382
ILE B 324
ASP B 325
 CL  B 971 ( 4.0A)
None
None
None
 1.07A 4pcuA-5x2oB:
undetectable		 4pcuA-5x2oB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c80 CYTOKININ OXIDASE
LUCKX1.1

(Linum
usitatissimum) 		no annotation 4 GLN A 520
PRO A 518
ILE A 106
ASP A  61
 FAD  A 601 (-3.9A)
None
None
None
 1.06A 4pcuA-6c80A:
undetectable		 4pcuA-6c80A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 4 ASP A 546
PRO A 663
THR A 519
ASP A 520
 None
 0.92A 4pcuA-6c9mA:
undetectable		 4pcuA-6c9mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza B
virus) 		no annotation 4 PHE A 223
ASP A 213
PRO A 217
ILE A 208
 None
 1.01A 4pcuA-6f5oA:
undetectable		 4pcuA-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gmb HYDROXYACID OXIDASE
1

(Homo sapiens) 		no annotation 4 PHE A 289
ASP A 291
PRO A  74
ILE A 278
 None
FMN  A 506 (-2.7A)
None
None
 0.99A 4pcuA-6gmbA:
undetectable		 4pcuA-6gmbA:
undetectable