SIMILAR PATTERNS OF AMINO ACIDS FOR 4PCL_B_SAMB301
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a99 | PUTRESCINE-BINDINGPROTEIN (Escherichiacoli) |
PF13416(SBP_bac_8) | 5 | PHE A 266ASN A 263ALA A 258ALA A 234ASN A 235 | None | 1.34A | 4pclB-1a99A:undetectable | 4pclB-1a99A:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1akc | ASPARTATEAMINOTRANSFERASE (Gallus gallus) |
PF00155(Aminotran_1_2) | 5 | GLU A 265GLY A 302ALA A 306ALA A 267TYR A 256 | None | 1.18A | 4pclB-1akcA:3.4 | 4pclB-1akcA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dpb | DIHYDROLIPOYL-TRANSACETYLASE (Azotobactervinelandii) |
PF00198(2-oxoacid_dh) | 5 | GLN A 437LEU A 606GLY A 626ALA A 630ALA A 441 | None | 1.34A | 4pclB-1dpbA:undetectable | 4pclB-1dpbA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fcu | HYALURONOGLUCOSAMINIDASE (Apis mellifera) |
PF01630(Glyco_hydro_56) | 5 | GLN A 40LEU A 39GLU A 49GLY A 48ALA A 52 | None | 1.10A | 4pclB-1fcuA:undetectable | 4pclB-1fcuA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gey | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Escherichiacoli) |
PF00155(Aminotran_1_2) | 5 | LEU A 79GLU A 86GLY A 83CYH A 223ALA A 84 | NoneNonePPE A 413 (-3.4A)NonePPE A 413 (-3.7A) | 1.25A | 4pclB-1geyA:3.6 | 4pclB-1geyA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h54 | MALTOSEPHOSPHORYLASE (Lactobacillusbrevis) |
PF03632(Glyco_hydro_65m)PF03633(Glyco_hydro_65C)PF03636(Glyco_hydro_65N) | 5 | GLN A 328LEU A 329GLY A 321ALA A 655TYR A 651 | None | 1.13A | 4pclB-1h54A:undetectable | 4pclB-1h54A:15.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ik6 | PYRUVATEDEHYDROGENASE (Pyrobaculumaerophilum) |
PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | LEU A 18GLU A 176ASN A 9ALA A 158ASN A 157 | None | 1.34A | 4pclB-1ik6A:2.7 | 4pclB-1ik6A:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mf1 | ADENYLOSUCCINATESYNTHETASE (Mus musculus) |
PF00709(Adenylsucc_synt) | 5 | LEU A 284GLY A 254ASN A 354ALA A 255ASN A 256 | NoneNoneNoneNoneAMP A 459 (-3.9A) | 1.37A | 4pclB-1mf1A:2.7 | 4pclB-1mf1A:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qfx | PROTEIN (PH 2.5 ACIDPHOSPHATASE) (Aspergillusniger) |
PF00328(His_Phos_2) | 5 | GLU A 159GLY A 155PHE A 316ALA A 452ALA A 458 | GOL A 702 (-3.2A)NoneNoneNoneNone | 1.39A | 4pclB-1qfxA:undetectable | 4pclB-1qfxA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qnr | ENDO-1,4-B-D-MANNANASE (Trichodermareesei) |
PF00150(Cellulase) | 5 | GLY A 119PHE A 110ASN A 113ALA A 122ASN A 125 | None | 1.34A | 4pclB-1qnrA:2.3 | 4pclB-1qnrA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qsp | YPD1 (Saccharomycescerevisiae) |
PF01627(Hpt) | 5 | GLN A 49LEU A 50GLY A 63ASN A 61ASN A 87 | None | 1.32A | 4pclB-1qspA:undetectable | 4pclB-1qspA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sus | CAFFEOYL-COAO-METHYLTRANSFERASE (Medicago sativa) |
PF01596(Methyltransf_3) | 5 | GLU A 85GLY A 87ALA A 140ALA A 164TYR A 172 | SAH A 301 (-4.1A)SAH A 301 (-3.4A)SAH A 301 (-3.9A)SAH A 301 ( 3.7A)None | 0.54A | 4pclB-1susA:26.8 | 4pclB-1susA:25.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sus | CAFFEOYL-COAO-METHYLTRANSFERASE (Medicago sativa) |
PF01596(Methyltransf_3) | 5 | GLY A 87ASN A 113ALA A 140ALA A 164TYR A 172 | SAH A 301 (-3.4A)NoneSAH A 301 (-3.9A)SAH A 301 ( 3.7A)None | 0.93A | 4pclB-1susA:26.8 | 4pclB-1susA:25.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bnh | RIBONUCLEASEINHIBITOR (Sus scrofa) |
PF13516(LRR_6) | 5 | LEU A 92GLY A 121CYH A 147ASN A 175ALA A 123 | None | 1.40A | 4pclB-2bnhA:undetectable | 4pclB-2bnhA:17.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dkj | SERINEHYDROXYMETHYLTRANSFERASE (Thermusthermophilus) |
PF00464(SHMT) | 5 | GLN A 90LEU A 260GLY A 234ALA A 199ASN A 98 | NoneNoneNonePLP A 510 (-3.4A)PLP A 510 ( 4.5A) | 1.27A | 4pclB-2dkjA:4.3 | 4pclB-2dkjA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f6i | ATP-DEPENDENT CLPPROTEASE, PUTATIVE (Plasmodiumfalciparum) |
PF00574(CLP_protease) | 5 | LEU A 315GLY A 240LYS A 205ALA A 208ALA A 242 | None | 1.39A | 4pclB-2f6iA:undetectable | 4pclB-2f6iA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gow | UBIQUITIN-LIKEPROTEIN 3 (Homo sapiens) |
PF13881(Rad60-SLD_2) | 5 | GLU A 48ASN A 70ALA A 90ALA A 36TYR A 40 | None | 1.39A | 4pclB-2gowA:undetectable | 4pclB-2gowA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hnk | SAM-DEPENDENTO-METHYLTRANSFERASE (Leptospirainterrogans) |
PF01596(Methyltransf_3) | 5 | GLU A 66GLY A 68ALA A 121ALA A 155TYR A 163 | SAH A2001 ( 4.2A)SAH A2001 (-3.3A)SAH A2001 (-3.3A)SAH A2001 ( 3.8A)None | 0.43A | 4pclB-2hnkA:28.2 | 4pclB-2hnkA:29.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jfq | GLUTAMATE RACEMASE (Staphylococcusaureus) |
PF01177(Asp_Glu_race) | 5 | GLN A 84LEU A 83ALA A 18ALA A 71TYR A 32 | None | 1.42A | 4pclB-2jfqA:3.6 | 4pclB-2jfqA:24.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nz9 | BOTULINUM NEUROTOXINTYPE A (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07951(Toxin_R_bind_C)PF07952(Toxin_trans)PF07953(Toxin_R_bind_N) | 5 | GLN A 988LEU A 987ASN A 970ALA A1049ASN A 935 | None | 1.19A | 4pclB-2nz9A:undetectable | 4pclB-2nz9A:10.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o5p | FERRIPYOVERDINERECEPTOR (Pseudomonasaeruginosa) |
PF00593(TonB_dep_Rec)PF07660(STN)PF07715(Plug) | 5 | LEU A 98GLY A 56PHE A 62ASN A 405ALA A 54 | None | 1.28A | 4pclB-2o5pA:undetectable | 4pclB-2o5pA:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qoj | INTRON-ENCODED DNAENDONUCLEASE I-ANII (Aspergillusnidulans) |
PF00961(LAGLIDADG_1) | 5 | GLN Z 230CYH Z 150LYS Z 202ALA Z 165TYR Z 244 | None | 1.36A | 4pclB-2qojZ:undetectable | 4pclB-2qojZ:24.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uzz | N-METHYL-L-TRYPTOPHAN OXIDASE (Escherichiacoli) |
PF01266(DAO) | 5 | LEU A 63GLY A 347PHE A 342ALA A 21ALA A 350 | None | 1.20A | 4pclB-2uzzA:3.2 | 4pclB-2uzzA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdc | GLUTAMATE SYNTHASE[NADPH] LARGE CHAIN (Azospirillumbrasilense) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 5 | LEU A1000GLY A1012ALA A 33ALA A1016ASN A1017 | None | 1.40A | 4pclB-2vdcA:2.1 | 4pclB-2vdcA:9.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vmx | SERINEHYDROXYMETHYLTRANSFERASE (Geobacillusstearothermophilus) |
PF00464(SHMT) | 5 | GLN A 90LEU A 259GLY A 234ALA A 199ASN A 98 | NoneNoneNonePLP A 501 (-3.6A)PLP A 501 ( 4.5A) | 1.21A | 4pclB-2vmxA:3.4 | 4pclB-2vmxA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ynm | LIGHT-INDEPENDENTPROTOCHLOROPHYLLIDEREDUCTASE SUBUNIT N (Prochlorococcusmarinus) |
PF00148(Oxidored_nitro) | 5 | GLY C 239PHE C 236ASN C 306ALA C 272ALA C 393 | None | 1.42A | 4pclB-2ynmC:3.7 | 4pclB-2ynmC:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3amj | ZINC PEPTIDASEINACTIVE SUBUNIT (Sphingomonassp. A1) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C) | 5 | GLN B 319GLY B 55ALA B 71ALA B 110TYR B 205 | None | 1.32A | 4pclB-3amjB:undetectable | 4pclB-3amjB:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c3y | O-METHYLTRANSFERASE (Mesembryanthemumcrystallinum) |
PF01596(Methyltransf_3) | 5 | GLU A 76GLY A 78ALA A 131ALA A 155TYR A 163 | SAH A 464 ( 4.2A)SAH A 464 (-3.7A)SAH A 464 (-3.5A)SAH A 464 (-3.7A)None | 0.34A | 4pclB-3c3yA:28.6 | 4pclB-3c3yA:27.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3cbg | O-METHYLTRANSFERASE (Synechocystissp. PCC 6803) |
PF01596(Methyltransf_3) | 6 | GLN A 43GLU A 66GLY A 68ALA A 121ALA A 144TYR A 152 | SAH A 301 (-4.4A)SAH A 301 ( 4.4A)SAH A 301 (-3.7A)SAH A 301 (-3.4A)SAH A 301 (-3.4A)None | 0.34A | 4pclB-3cbgA:28.1 | 4pclB-3cbgA:33.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cea | MYO-INOSITOL2-DEHYDROGENASE (Lactobacillusplantarum) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | GLN A 203LEU A 229GLY A 206ALA A 335ASN A 336 | None | 1.36A | 4pclB-3ceaA:7.4 | 4pclB-3ceaA:20.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dul | O-METHYLTRANSFERASE,PUTATIVE (Bacillus cereus) |
PF01596(Methyltransf_3) | 5 | GLU A 64GLY A 66ALA A 119ALA A 141ASN A 145 | None | 0.96A | 4pclB-3dulA:24.3 | 4pclB-3dulA:32.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dul | O-METHYLTRANSFERASE,PUTATIVE (Bacillus cereus) |
PF01596(Methyltransf_3) | 5 | GLU A 64GLY A 66ALA A 119ALA A 141TYR A 149 | None | 0.79A | 4pclB-3dulA:24.3 | 4pclB-3dulA:32.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ed3 | PROTEINDISULFIDE-ISOMERASEMPD1 (Saccharomycescerevisiae) |
PF00085(Thioredoxin) | 5 | LEU A 274GLY A 200PHE A 278ASN A 47TYR A 156 | NoneNoneNoneACT A1108 (-4.0A)None | 1.42A | 4pclB-3ed3A:undetectable | 4pclB-3ed3A:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g8m | SERINEHYDROXYMETHYLTRANSFERASE (Escherichiacoli) |
PF00464(SHMT) | 5 | LEU A 265GLY A 237ASN A 92ALA A 202ASN A 102 | None | 1.40A | 4pclB-3g8mA:4.9 | 4pclB-3g8mA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyb | TRANSCRIPTIONALREGULATORS(LACI-FAMILYTRANSCRIPTIONALREGULATORY PROTEIN) (Corynebacteriumglutamicum) |
PF13377(Peripla_BP_3) | 5 | LEU A 299GLY A 144ALA A 188ALA A 157ASN A 158 | None | 1.29A | 4pclB-3gybA:5.2 | 4pclB-3gybA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h7f | SERINEHYDROXYMETHYLTRANSFERASE 1 (Mycobacteriumtuberculosis) |
PF00464(SHMT) | 5 | GLN A 91LEU A 260GLY A 235ALA A 200ASN A 99 | NoneNoneNoneLLP A 227 ( 3.6A)LLP A 227 ( 4.7A) | 1.38A | 4pclB-3h7fA:5.2 | 4pclB-3h7fA:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jyn | QUINONEOXIDOREDUCTASE (Pseudomonassyringae groupgenomosp. 3) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLN A 6LEU A 16GLY A 93ALA A 94ASN A 35 | None | 1.33A | 4pclB-3jynA:8.2 | 4pclB-3jynA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kom | TRANSKETOLASE (Francisellatularensis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | GLU A 167GLY A 414ALA A 445ALA A 123ASN A 124 | None | 1.18A | 4pclB-3komA:undetectable | 4pclB-3komA:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kqf | ENOYL-COAHYDRATASE/ISOMERASEFAMILY PROTEIN (Bacillusanthracis) |
PF00378(ECH_1) | 5 | LEU A 190GLU A 61GLY A 60ALA A 59ASN A 22 | None | 1.34A | 4pclB-3kqfA:undetectable | 4pclB-3kqfA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lkb | PROBABLEBRANCHED-CHAIN AMINOACID ABCTRANSPORTER, AMINOACID BINDING PROTEIN (Thermusthermophilus) |
PF13458(Peripla_BP_6) | 5 | PHE A 67ALA A 23ALA A 104ASN A 289TYR A 232 | NoneNoneVAL A 393 (-3.4A)NoneVAL A 393 (-4.0A) | 1.27A | 4pclB-3lkbA:4.0 | 4pclB-3lkbA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mkt | MULTI ANTIMICROBIALEXTRUSION PROTEIN(NA(+)/DRUGANTIPORTER)MATE-LIKE MDR EFFLUXPUMP (Vibrio cholerae) |
PF01554(MatE) | 5 | GLY A 313ASN A 14ALA A 315ASN A 319TYR A 445 | None | 1.39A | 4pclB-3mktA:undetectable | 4pclB-3mktA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0l | SERINEHYDROXYMETHYLTRANSFERASE (Campylobacterjejuni) |
PF00464(SHMT) | 5 | GLN A 89LEU A 258GLY A 232ALA A 197ASN A 97 | None | 1.23A | 4pclB-3n0lA:3.7 | 4pclB-3n0lA:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p2y | ALANINEDEHYDROGENASE/PYRIDINE NUCLEOTIDETRANSHYDROGENASE (Mycolicibacteriumsmegmatis) |
PF01262(AlaDh_PNT_C)PF05222(AlaDh_PNT_N) | 5 | GLN A 131GLY A 89ASN A 71ALA A 110ALA A 112 | None | 1.39A | 4pclB-3p2yA:4.9 | 4pclB-3p2yA:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pgy | SERINEHYDROXYMETHYLTRANSFERASE (Staphylococcusaureus) |
PF00464(SHMT) | 5 | GLN A 90LEU A 259GLY A 234ALA A 199ASN A 98 | None | 1.28A | 4pclB-3pgyA:3.7 | 4pclB-3pgyA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tfw | PUTATIVEO-METHYLTRANSFERASE (Klebsiellapneumoniae) |
PF01596(Methyltransf_3) | 5 | GLU A 67GLY A 69ALA A 122ALA A 142TYR A 150 | None | 0.26A | 4pclB-3tfwA:28.0 | 4pclB-3tfwA:29.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tr6 | O-METHYLTRANSFERASE (Coxiellaburnetii) |
PF01596(Methyltransf_3) | 5 | GLN A 44GLY A 69ALA A 122ALA A 145TYR A 153 | NoneSAH A 224 (-3.9A)SAH A 224 (-3.8A)SAH A 224 (-3.5A)None | 0.61A | 4pclB-3tr6A:29.0 | 4pclB-3tr6A:28.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u3g | RIBONUCLEASE H (unculturedorganism) |
no annotation | 5 | LEU D 139GLU D 42GLY D 17ALA D 12ASN D 45 | None | 1.28A | 4pclB-3u3gD:undetectable | 4pclB-3u3gD:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uk1 | TRANSKETOLASE (Burkholderiathailandensis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | GLU A 185GLY A 438ALA A 469ALA A 141ASN A 142 | None | 1.12A | 4pclB-3uk1A:2.2 | 4pclB-3uk1A:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v0a | NTNH (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07953(Toxin_R_bind_N)PF08470(NTNH_C) | 5 | GLN B 385LEU B 386GLY B 380ASN B 858ASN B 375 | None | 1.13A | 4pclB-3v0aB:undetectable | 4pclB-3v0aB:11.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3voh | CELLOBIOHYDROLASE (Coprinopsiscinerea) |
PF01341(Glyco_hydro_6) | 5 | LEU A 322GLY A 254ASN A 294ALA A 213ASN A 214 | NoneNoneCT3 A1002 (-3.9A)NoneCT3 A1002 ( 4.9A) | 1.37A | 4pclB-3vohA:undetectable | 4pclB-3vohA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wfl | BETA-MANNANASE (Talaromycestrachyspermus) |
PF00150(Cellulase) | 5 | GLY A 151PHE A 142ASN A 145ALA A 154ASN A 157 | None | 1.32A | 4pclB-3wflA:2.6 | 4pclB-3wflA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aoa | BETA-PHENYLALANINEAMINOTRANSFERASE (Variovoraxparadoxus) |
PF00202(Aminotran_3) | 5 | GLY A 346CYH A 342PHE A 422ALA A 433ASN A 434 | None | 1.22A | 4pclB-4aoaA:3.3 | 4pclB-4aoaA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bju | N-ACETYLGLUCOSAMINE-PHOSPHATE MUTASE (Aspergillusfumigatus) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I) | 5 | GLU A 86GLY A 85ALA A 424ASN A 422TYR A 183 | None | 1.35A | 4pclB-4bjuA:undetectable | 4pclB-4bjuA:17.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bz0 | PUTATIVE TYPE IVPILUS BIOSYNTHESISPROTEIN (Burkholderiapseudomallei) |
PF06864(PAP_PilO) | 5 | LEU A 168GLY A 83ALA A 93ASN A 144TYR A 86 | None | 1.31A | 4pclB-4bz0A:undetectable | 4pclB-4bz0A:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c1n | IRON-SULFUR CLUSTERBINDING PROTEIN (Carboxydothermushydrogenoformans) |
PF14574(DUF4445) | 5 | GLU I 404GLY I 405CYH I 445ALA I 402ASN I 509 | NoneNoneNoneNoneB12 I1631 (-4.2A) | 1.43A | 4pclB-4c1nI:undetectable | 4pclB-4c1nI:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cfi | FLAGELLIN (Burkholderiapseudomallei) |
PF00669(Flagellin_N)PF12613(FliC_SP) | 5 | GLN A 300LEU A 290GLY A 172ASN A 282ALA A 245 | None | 1.37A | 4pclB-4cfiA:undetectable | 4pclB-4cfiA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4csi | CELLULASE (Humicola grisea) |
PF00840(Glyco_hydro_7) | 5 | LEU A 380GLY A 399PHE A 386LYS A 272ALA A 400 | None | 1.36A | 4pclB-4csiA:undetectable | 4pclB-4csiA:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ecn | LEUCINE-RICH REPEATPROTEIN (Bacteroidesthetaiotaomicron) |
PF14660(DUF4458) | 5 | LEU A 605GLY A 584CYH A 608ALA A 551ASN A 553 | None | 1.27A | 4pclB-4ecnA:undetectable | 4pclB-4ecnA:14.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j5u | SERINEHYDROXYMETHYLTRANSFERASE (Rickettsiarickettsii) |
PF00464(SHMT) | 5 | GLN A 94LEU A 264GLY A 238ALA A 203ASN A 102 | NoneNoneNoneLLP A 230 ( 3.4A)LLP A 230 ( 4.5A) | 1.27A | 4pclB-4j5uA:4.3 | 4pclB-4j5uA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jqt | PUTATIVE GLYCOSYLHYDROLASE (Bacteroidesthetaiotaomicron) |
PF06439(DUF1080) | 5 | GLN A 107LEU A 90GLY A 119ALA A 142ASN A 149 | NA A 501 (-3.0A)NoneNoneNoneNone | 1.19A | 4pclB-4jqtA:undetectable | 4pclB-4jqtA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l27 | CYSTATHIONINEBETA-SYNTHASE (Homo sapiens) |
no annotation | 5 | GLN B 222LEU B 220GLY B 153ASN B 149ALA B 155 | NoneNoneNonePLP B 601 (-3.5A)None | 1.38A | 4pclB-4l27B:2.6 | 4pclB-4l27B:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m9p | FILAMIN-A (Homo sapiens) |
PF00630(Filamin) | 5 | GLU A 587GLY A 588ALA A 595ALA A 661TYR A 635 | None | 1.38A | 4pclB-4m9pA:undetectable | 4pclB-4m9pA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o5p | UNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF09994(DUF2235) | 5 | LEU A 67GLU A 240GLY A 237ASN A 74ALA A 238 | None | 1.35A | 4pclB-4o5pA:undetectable | 4pclB-4o5pA:13.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4obu | PYRIDOXAL-DEPENDENTDECARBOXYLASE DOMAINPROTEIN ([Ruminococcus]gnavus) |
no annotation | 5 | GLN E 190GLY E 247PHE E 218ALA E 279ALA E 246 | None | 1.17A | 4pclB-4obuE:3.5 | 4pclB-4obuE:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p49 | ANTIBODY SCFV B8 (Gallus gallus) |
PF07686(V-set) | 5 | GLY A 28PHE A 57ASN A 47ALA A 229ASN A 227 | NoneNoneNoneNoneSO4 A 301 ( 4.0A) | 1.39A | 4pclB-4p49A:undetectable | 4pclB-4p49A:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p6v | NA(+)-TRANSLOCATINGNADH-QUINONEREDUCTASE SUBUNIT B (Vibrio cholerae) |
PF03116(NQR2_RnfD_RnfE) | 5 | GLY B 125PHE B 69ASN B 74ALA B 228TYR B 102 | None | 1.39A | 4pclB-4p6vB:undetectable | 4pclB-4p6vB:19.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4pcl | O-METHYLTRANSFERASEFAMILY PROTEIN (Anaplasmaphagocytophilum) |
PF01596(Methyltransf_3) | 12 | GLN A 39LEU A 40GLU A 62GLY A 64CYH A 66PHE A 69LYS A 89ASN A 93ALA A 117ALA A 137ASN A 138TYR A 145 | SAM A 301 (-4.9A)SAM A 301 (-3.7A)SAM A 301 ( 4.4A)SAM A 301 (-3.4A)SAM A 301 (-4.2A)NoneSAM A 301 (-3.2A)SAM A 301 (-4.2A)SAM A 301 (-3.3A)SAM A 301 ( 3.9A)SAM A 301 (-3.4A)None | 0.22A | 4pclB-4pclA:40.6 | 4pclB-4pclA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qqs | GLYCOSIDE HYDROLASEFAMILY 43 (Halothermothrixorenii) |
PF04616(Glyco_hydro_43) | 5 | PHE A 78ALA A 99ALA A 101ASN A 112TYR A 87 | None | 1.34A | 4pclB-4qqsA:undetectable | 4pclB-4qqsA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wd9 | NISIN BIOSYNTHESISPROTEIN NISB (Lactococcuslactis) |
PF04738(Lant_dehydr_N)PF14028(Lant_dehydr_C) | 5 | LEU A 300ASN A 508ALA A 49ASN A 50TYR A 80 | None | 1.25A | 4pclB-4wd9A:undetectable | 4pclB-4wd9A:12.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wxb | SERINEHYDROXYMETHYLTRANSFERASE (Streptococcusthermophilus) |
PF00464(SHMT) | 5 | GLN A 88LEU A 258GLY A 232ALA A 197ASN A 96 | None | 1.26A | 4pclB-4wxbA:3.1 | 4pclB-4wxbA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ymg | PUTATIVESAM-DEPENDENTO-METHYLTRANFERASE (Podosporaanserina) |
PF01596(Methyltransf_3) | 6 | GLU A 71GLY A 73ALA A 127ALA A 145ASN A 146TYR A 153 | SAM A1001 ( 4.4A)SAM A1001 (-3.3A)SAM A1001 (-3.4A)SAM A1001 ( 3.5A)SAM A1001 ( 3.5A)None | 0.43A | 4pclB-4ymgA:26.2 | 4pclB-4ymgA:24.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8r | METHYL-COENZYME MREDUCTASE II SUBUNITGAMMA (Methanothermobactermarburgensis) |
PF02241(MCR_beta)PF02783(MCR_beta_N) | 5 | GLN B 110GLU B 54GLY B 55ASN B 49ALA B 61 | None | 1.34A | 4pclB-5a8rB:undetectable | 4pclB-5a8rB:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ahk | ACETOLACTATESYNTHASE II, LARGESUBUNIT (Pseudomonasprotegens) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | GLN A 450LEU A 451GLY A 445ASN A 472ASN A 396 | NoneNoneTPP A 700 (-3.6A)NoneTPP A 700 (-4.0A) | 1.34A | 4pclB-5ahkA:4.3 | 4pclB-5ahkA:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dl7 | PORIN (Acinetobacterbaumannii) |
PF03573(OprD) | 5 | LEU A 10GLY A 37PHE A 40ALA A 35ASN A 14 | NoneNoneNoneNoneC8E A 510 (-4.1A) | 1.38A | 4pclB-5dl7A:undetectable | 4pclB-5dl7A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ehf | LACCASE (Antrodiellafaginea) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | GLU A 467GLY A 445PHE A 69ASN A 83ALA A 472 | None | 1.30A | 4pclB-5ehfA:undetectable | 4pclB-5ehfA:16.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eio | N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE/N-ACETYL-GAMMA-AMINOADIPYL-PHOSPHATE REDUCTASE (Thermusthermophilus) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | LEU A 97GLY A 316CYH A 148ASN A 149ALA A 291 | NAP A 401 (-4.9A)NoneNAP A 401 ( 3.7A)NoneNone | 1.34A | 4pclB-5eioA:undetectable | 4pclB-5eioA:18.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5elg | GLUTATHIONES-TRANSFERASE DHAR1,MITOCHONDRIAL (Arabidopsisthaliana) |
PF13410(GST_C_2)PF13417(GST_N_3) | 5 | LEU A 27GLY A 18CYH A 20ALA A 9ASN A 43 | NoneNoneGSH A 302 (-3.0A)NoneNone | 1.09A | 4pclB-5elgA:undetectable | 4pclB-5elgA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5elg | GLUTATHIONES-TRANSFERASE DHAR1,MITOCHONDRIAL (Arabidopsisthaliana) |
PF13410(GST_C_2)PF13417(GST_N_3) | 5 | LEU A 27GLY A 18CYH A 20ALA A 13ALA A 9 | NoneNoneGSH A 302 (-3.0A)NoneNone | 1.38A | 4pclB-5elgA:undetectable | 4pclB-5elgA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fbz | ENZYME SUBTILASESUBHAL FROM BACILLUSHALMAPALUS (Bacillushalmapalus) |
PF00082(Peptidase_S8)PF04151(PPC) | 5 | LEU A 315GLU A 269GLY A 21PHE A 17ALA A 265 | None | 1.41A | 4pclB-5fbzA:undetectable | 4pclB-5fbzA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hr4 | MMEI (Methylophilusmethylotrophus) |
no annotation | 5 | LEU C 865GLY C 854ASN C 849ALA C 853ASN C 684 | None | 1.42A | 4pclB-5hr4C:11.4 | 4pclB-5hr4C:14.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i33 | ADENYLOSUCCINATESYNTHETASE (Cryptococcusneoformans) |
PF00709(Adenylsucc_synt) | 5 | LEU A 257GLY A 227ASN A 327ALA A 228ASN A 229 | None | 1.31A | 4pclB-5i33A:2.9 | 4pclB-5i33A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j32 | 3-ISOPROPYLMALATEDEHYDROGENASE 2,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00180(Iso_dh) | 5 | LEU A 95GLY A 85LYS A 118ASN A 122ALA A 86 | None | 1.39A | 4pclB-5j32A:undetectable | 4pclB-5j32A:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kva | CAFFEOYL-COAO-METHYLTRANSFERASE (Sorghum bicolor) |
PF01596(Methyltransf_3) | 5 | GLU A 99GLY A 101ALA A 154ALA A 178TYR A 186 | SAM A 301 ( 4.0A)SAM A 301 (-3.4A)SAM A 301 (-3.7A)SAM A 301 (-3.7A)None | 0.45A | 4pclB-5kvaA:27.5 | 4pclB-5kvaA:27.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kva | CAFFEOYL-COAO-METHYLTRANSFERASE (Sorghum bicolor) |
PF01596(Methyltransf_3) | 5 | GLY A 101ASN A 127ALA A 154ALA A 178TYR A 186 | SAM A 301 (-3.4A)NoneSAM A 301 (-3.7A)SAM A 301 (-3.7A)None | 0.93A | 4pclB-5kvaA:27.5 | 4pclB-5kvaA:27.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kws | GALACTOSE-BINDINGPROTEIN (Yersinia pestis) |
PF13407(Peripla_BP_4) | 5 | LEU A 145GLY A 234PHE A 143ALA A 241ALA A 215 | None | 1.43A | 4pclB-5kwsA:4.6 | 4pclB-5kwsA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l2e | GLUTAMATE RECEPTORIONOTROPIC,DELTA-2,GLUTAMATERECEPTOR IONOTROPIC,DELTA-2 (Rattusnorvegicus) |
PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 5 | GLN A 120GLU A 264GLY A 125ALA A 237ALA A 124 | None | 1.13A | 4pclB-5l2eA:4.7 | 4pclB-5l2eA:15.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5log | PUTATIVEO-METHYLTRANSFERASE (Myxococcusxanthus) |
PF01596(Methyltransf_3) | 5 | GLU A 65GLY A 67ALA A 120ALA A 143TYR A 151 | SAH A1001 ( 4.4A)SAH A1001 (-3.5A)SAH A1001 (-3.4A)SAH A1001 (-3.7A)None | 0.37A | 4pclB-5logA:28.9 | 4pclB-5logA:31.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mvd | DIHYDROOROTATEDEHYDROGENASE(QUINONE),MITOCHONDRIAL (Homo sapiens) |
PF01180(DHO_dh) | 5 | LEU A 355GLY A 97ASN A 145ALA A 96ASN A 181 | FMN A 401 (-4.9A)FMN A 401 (-3.3A)ORO A 402 ( 3.1A)FMN A 401 (-3.4A)FMN A 401 (-3.1A) | 1.42A | 4pclB-5mvdA:undetectable | 4pclB-5mvdA:21.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n5d | METHYLTRANSFERASE (Streptomycesregensis) |
PF01596(Methyltransf_3) | 6 | GLU A 63GLY A 65ALA A 118ALA A 140ASN A 141TYR A 148 | SAM A 306 ( 3.6A)SAM A 306 (-3.2A)SAM A 306 (-3.5A)SAM A 306 (-3.6A)SAM A 306 ( 2.9A)None | 0.24A | 4pclB-5n5dA:29.4 | 4pclB-5n5dA:31.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5n5d | METHYLTRANSFERASE (Streptomycesregensis) |
PF01596(Methyltransf_3) | 5 | LEU A 49GLU A 63GLY A 65ALA A 118TYR A 148 | BU3 A 301 ( 3.7A)SAM A 306 ( 3.6A)SAM A 306 (-3.2A)SAM A 306 (-3.5A)None | 1.33A | 4pclB-5n5dA:29.4 | 4pclB-5n5dA:31.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ool | 39S RIBOSOMALPROTEIN L46,MITOCHONDRIAL (Homo sapiens) |
PF00297(Ribosomal_L3) | 5 | GLN e 54LEU e 238CYH e 52ALA e 176ALA e 188 | None | 1.36A | 4pclB-5oole:undetectable | 4pclB-5oole:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ujw | TRIOSEPHOSPHATEISOMERASE (Francisellatularensis) |
PF00121(TIM) | 5 | GLN A 52GLY A 24CYH A 22LYS A 236ALA A 238 | None | 1.33A | 4pclB-5ujwA:undetectable | 4pclB-5ujwA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ukh | UNCHARACTERIZEDPROTEIN (Streptococcusintermedius) |
no annotation | 5 | GLN A 336LEU A 335GLY A 278ASN A 283ALA A 410 | None | 1.30A | 4pclB-5ukhA:undetectable | 4pclB-5ukhA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7f | PUTATIVEO-METHYLTRANSFERASERV1220C (Mycobacteriumtuberculosis) |
PF01596(Methyltransf_3) | 5 | GLU A 64GLY A 66ALA A 120ALA A 139TYR A 147 | SAM A 301 ( 4.7A)SAM A 301 (-3.5A)SAM A 301 (-3.5A)SAM A 301 (-3.5A)None | 0.39A | 4pclB-5x7fA:26.7 | 4pclB-5x7fA:25.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z7r | SHORT-CHAIN-ENOYL-COA HYDRATASE (Clostridiumacetobutylicum) |
no annotation | 5 | LEU A 188GLU A 59GLY A 58ALA A 57ASN A 20 | None | 1.33A | 4pclB-5z7rA:undetectable | 4pclB-5z7rA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b07 | FARNESYL DIPHOSPHATESYNTHASE (Choristoneurafumiferana) |
no annotation | 5 | LEU A 384GLY A 257CYH A 255ALA A 261ASN A 262 | None | 1.39A | 4pclB-6b07A:undetectable | 4pclB-6b07A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b2y | SOLUTE-BINDINGPERIPLASMIC PROTEINOF IRON/SIDEROPHOREABC TRANSPORTER (Yersinia pestis) |
no annotation | 5 | GLN A 332LEU A 329GLY A 36PHE A 157ALA A 335 | None | 1.28A | 4pclB-6b2yA:undetectable | 4pclB-6b2yA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6chd | LYSINE--TRNA LIGASE (Homo sapiens) |
no annotation | 5 | GLN A 515GLU A 301GLY A 277ASN A 272TYR A 303 | NoneKAA A 601 (-3.0A)KAA A 601 (-4.7A)NoneNone | 1.32A | 4pclB-6chdA:undetectable | 4pclB-6chdA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eoq | DIPEPTIDYL PEPTIDASE9 (Homo sapiens) |
no annotation | 5 | GLN A 373LEU A 376LYS A 314ASN A 312ALA A 316 | None | 1.31A | 4pclB-6eoqA:2.3 | 4pclB-6eoqA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eti | ATP-BINDING CASSETTESUB-FAMILY G MEMBER2 (Homo sapiens) |
no annotation | 5 | GLN A 437LEU A 433PHE A 489ALA A 580ASN A 629 | None | 1.35A | 4pclB-6etiA:2.2 | 4pclB-6etiA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g01 | ENDOGLUCANASE (Bacillus sp.KSM-635) |
PF00150(Cellulase)PF03424(CBM_17_28) | 4 | SER A 461GLU A 392GLU A 399ASP A 429 | None | 1.36A | 4pclB-1g01A:0.9 | 4pclB-1g01A:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5a | AMIDE SYNTHASE (Vibrio cholerae) |
PF00668(Condensation) | 4 | SER A 174GLU A 168GLU A 314ASP A 180 | None | 1.33A | 4pclB-1l5aA:0.0 | 4pclB-1l5aA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1on9 | METHYLMALONYL-COACARBOXYLTRANSFERASE12S SUBUNIT (Propionibacteriumfreudenreichii) |
PF01039(Carboxyl_trans) | 4 | SER A 102GLU A 49GLU A 37ASP A 139 | None | 1.49A | 4pclB-1on9A:0.6 | 4pclB-1on9A:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ggj | N-ACYLAMINO ACIDRACEMASE (Deinococcusradiodurans) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | SER A 324GLU A 300GLU A 57ASP A 322 | None | 1.47A | 4pclB-2ggjA:0.7 | 4pclB-2ggjA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iv0 | SUSD HOMOLOG (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 4 | SER A 211GLU A 289GLU A 448ASP A 284 | None | 0.96A | 4pclB-3iv0A:0.0 | 4pclB-3iv0A:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m85 | PROBABLE EXOSOMECOMPLEX EXONUCLEASE2 (Archaeoglobusfulgidus) |
PF01138(RNase_PH)PF03725(RNase_PH_C) | 4 | SER G 228GLU G 100GLU G 94ASP G 209 | None | 1.32A | 4pclB-3m85G:0.0 | 4pclB-3m85G:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3muu | STRUCTURALPOLYPROTEIN (Sindbis virus) |
PF00943(Alpha_E2_glycop)PF01589(Alpha_E1_glycop) | 4 | SER A 632GLU A 327GLU A 334ASP A 630 | None | 1.43A | 4pclB-3muuA:undetectable | 4pclB-3muuA:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s9x | ASCH DOMAIN (Vibrio cholerae) |
PF04266(ASCH) | 4 | SER A 28GLU A 147GLU A 109ASP A 30 | None | 0.99A | 4pclB-3s9xA:undetectable | 4pclB-3s9xA:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wdo | MFS TRANSPORTER (Escherichiacoli) |
PF07690(MFS_1) | 4 | SER A 190GLU A 130GLU A 272ASP A 126 | None | 1.48A | 4pclB-3wdoA:0.0 | 4pclB-3wdoA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ida | RIPENING-INDUCEDPROTEIN (Fragaria vesca) |
PF08240(ADH_N)PF13602(ADH_zinc_N_2) | 4 | SER A 190GLU A 225GLU A 218ASP A 210 | EDO A 403 ( 4.3A)NoneNoneNone | 1.47A | 4pclB-4idaA:6.5 | 4pclB-4idaA:20.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4pcl | O-METHYLTRANSFERASEFAMILY PROTEIN (Anaplasmaphagocytophilum) |
PF01596(Methyltransf_3) | 4 | SER A 70GLU A 88GLU A 116ASP A 136 | SAM A 301 (-2.9A)SAM A 301 (-2.6A)SAM A 301 (-3.9A) MN A 303 ( 2.7A) | 0.15A | 4pclB-4pclA:40.6 | 4pclB-4pclA:100.00 |