SIMILAR PATTERNS OF AMINO ACIDS FOR 4PBH_A_BEZA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum) 		PF00191
(Annexin) 		5 ILE A 242
THR A 241
ALA A 202
LEU A 238
LEU A 156
 None
 1.12A 4pbhA-1dk5A:
0.0		 4pbhA-1dk5A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		5 ILE A  47
LEU A  44
ASP A 408
LEU A 415
PHE A  31
 None
 1.34A 4pbhA-1e6zA:
0.5		 4pbhA-1e6zA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 ILE A 304
THR A 303
THR A 572
LEU A 300
LEU A 414
 None
 0.89A 4pbhA-1ebvA:
0.0		 4pbhA-1ebvA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j7g D-TYROSYL-TRNA(TYR)
DEACYLASE

(Haemophilus
influenzae) 		PF02580
(Tyr_Deacylase) 		5 ILE A  23
ALA A  69
LEU A  73
LEU A 117
PHE A  55
 None
 1.36A 4pbhA-1j7gA:
undetectable		 4pbhA-1j7gA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1je6 MHC CLASS I
CHAIN-RELATED
PROTEIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 ILE A  80
THR A  76
TRP A 146
LEU A  90
LEU A  73
 None
 1.43A 4pbhA-1je6A:
undetectable		 4pbhA-1je6A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfl ASPARTATE RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		5 ILE A 181
THR A 178
THR A 148
LEU A 182
LEU A 122
 None
 1.30A 4pbhA-1jflA:
1.0		 4pbhA-1jflA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		5 ARG A 728
LEU A1006
ASP A1002
LEU A1000
PHE A 754
 None
 1.46A 4pbhA-1k32A:
0.0		 4pbhA-1k32A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nqz COA PYROPHOSPHATASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Deinococcus
radiodurans) 		PF00293
(NUDIX) 		5 ILE A 139
THR A 141
ALA A  41
LEU A 130
LEU A  93
 None
 1.23A 4pbhA-1nqzA:
0.0		 4pbhA-1nqzA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		5 ILE A 280
THR A 307
LEU A 256
ASP A 178
LEU A 179
 None
 1.28A 4pbhA-1ru3A:
0.5		 4pbhA-1ru3A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		5 ILE A 132
ALA A 152
LEU A 130
ASP A 153
LEU A 162
 None
 1.06A 4pbhA-1su7A:
undetectable		 4pbhA-1su7A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF

(Pseudomonas
fluorescens) 		PF02567
(PhzC-PhzF) 		5 ILE A  60
THR A  47
ALA A  82
LEU A  94
LEU A  92
 None
 1.47A 4pbhA-1t6kA:
undetectable		 4pbhA-1t6kA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ILE A  74
THR A  36
LEU A  81
ASP A  59
LEU A  62
 UMA  A 963 ( 4.4A)
UMA  A 963 (-3.3A)
None
None
None
 1.46A 4pbhA-1uagA:
undetectable		 4pbhA-1uagA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf3 GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		5 ILE A 196
THR A 260
ALA A 232
LEU A 264
LEU A 274
 None
 1.34A 4pbhA-1wf3A:
undetectable		 4pbhA-1wf3A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx0 TRANSALDOLASE

(Thermus
thermophilus) 		PF00923
(TAL_FSA) 		5 THR A  26
THR A 116
ALA A 172
ARG A 141
PHE A 138
 None
 1.17A 4pbhA-1wx0A:
undetectable		 4pbhA-1wx0A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		5 ILE X 498
THR X 502
LEU X 495
LEU X 512
PHE X 561
 None
 1.33A 4pbhA-1z3iX:
undetectable		 4pbhA-1z3iX:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2q G/U
MISMATCH-SPECIFIC
DNA GLYCOSYLASE

(Deinococcus
radiodurans) 		PF03167
(UDG) 		5 TRP A 173
THR A 121
LEU A  28
LEU A  62
PHE A  53
 None
 1.01A 4pbhA-2c2qA:
undetectable		 4pbhA-2c2qA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 THR A 204
ALA A 666
LEU A 605
ASP A 664
LEU A 631
 MGD  A 802 (-4.2A)
None
MGD  A 802 (-4.4A)
None
None
 1.33A 4pbhA-2e7zA:
undetectable		 4pbhA-2e7zA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgn PHOSPHOLIPASE C

(Bacillus cereus) 		PF00882
(Zn_dep_PLPC) 		5 ILE A  51
ALA A  21
ARG A  44
LEU A  47
LEU A  40
 None
 1.27A 4pbhA-2fgnA:
undetectable		 4pbhA-2fgnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irw CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1

(Homo sapiens) 		PF00106
(adh_short) 		5 THR A  64
ALA A 106
LEU A 116
LEU A 113
PHE A 102
 None
 1.49A 4pbhA-2irwA:
undetectable		 4pbhA-2irwA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knr UNCHARACTERIZED
PROTEIN ATC0905

(Agrobacterium
fabrum) 		PF07372
(DUF1491) 		5 ILE A 106
THR A 103
ALA A  23
LEU A 110
LEU A  12
 None
 1.34A 4pbhA-2knrA:
undetectable		 4pbhA-2knrA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		5 ILE A 240
THR A 237
ALA A 159
LEU A 241
PHE A  39
 ILE  A 240 ( 0.7A)
THR  A 237 ( 0.8A)
ALA  A 159 ( 0.0A)
LEU  A 241 ( 0.6A)
PHE  A  39 ( 1.3A)
 0.85A 4pbhA-2ogsA:
undetectable		 4pbhA-2ogsA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5c NTRC FAMILY
TRANSCRIPTIONAL
REGULATOR

(Clostridium
acetobutylicum) 		PF06506
(PrpR_N) 		5 ILE A 155
THR A 151
ALA A  88
ARG A  90
PHE A  91
 None
 1.33A 4pbhA-2q5cA:
undetectable		 4pbhA-2q5cA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0j UBIQUITIN CARRIER
PROTEIN

(Plasmodium
falciparum) 		PF00179
(UQ_con) 		5 ILE A   6
THR A  10
ALA A  23
LEU A  56
LEU A  54
 None
 1.42A 4pbhA-2r0jA:
undetectable		 4pbhA-2r0jA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		5 ILE A 251
THR A  25
THR A  12
LEU A  29
LEU A  56
 None
 1.12A 4pbhA-2rb5A:
undetectable		 4pbhA-2rb5A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE

(Oceanicola
granulosus) 		PF07555
(NAGidase) 		5 ILE A 329
ALA A 430
LEU A 356
LEU A 396
PHE A 427
 None
 1.26A 4pbhA-2xsbA:
undetectable		 4pbhA-2xsbA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu0 PROTEIN SUFD

(Escherichia
coli) 		PF01458
(UPF0051) 		5 ILE A 110
THR A 138
HIS A 173
LEU A  86
LEU A 154
 None
 1.47A 4pbhA-2zu0A:
undetectable		 4pbhA-2zu0A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 ILE A 238
THR A 141
LEU A 216
LEU A 208
PHE A 127
 None
 1.35A 4pbhA-3bo5A:
undetectable		 4pbhA-3bo5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		5 ILE A 238
HIS A 146
ARG A 130
LEU A 126
LEU A 152
 None
 1.30A 4pbhA-3bs8A:
undetectable		 4pbhA-3bs8A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clm TRANSALDOLASE

(Neisseria
gonorrhoeae) 		PF00923
(TAL_FSA) 		5 THR A  41
THR A 162
ALA A 258
ARG A 204
PHE A 201
 None
CL  A 352 (-3.4A)
EDO  A 354 (-3.5A)
SO4  A 353 ( 3.9A)
EDO  A 354 ( 4.3A)
 1.06A 4pbhA-3clmA:
undetectable		 4pbhA-3clmA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ea0 ATPASE, PARA FAMILY

(Chlorobaculum
tepidum) 		PF13614
(AAA_31) 		5 ILE A 232
THR A 231
ALA A 179
LEU A 228
ASP A 180
 None
None
None
ATP  A 243 ( 4.6A)
None
 1.48A 4pbhA-3ea0A:
1.6		 4pbhA-3ea0A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eea GAF DOMAIN/HD DOMAIN
PROTEIN

(Geobacter
sulfurreducens) 		PF13492
(GAF_3) 		5 ILE A  72
ALA A 111
LEU A  96
LEU A  87
PHE A 125
 PG6  A 163 (-4.4A)
None
None
None
PG6  A 163 ( 4.2A)
 1.18A 4pbhA-3eeaA:
undetectable		 4pbhA-3eeaA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqe PUTATIVE CYSTEIN
DIOXYGENASE

(Bacillus
subtilis) 		PF05995
(CDO_I) 		5 ILE A  66
HIS A 139
THR A  72
LEU A  91
LEU A 117
 None
 1.34A 4pbhA-3eqeA:
undetectable		 4pbhA-3eqeA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE

(Psychrobacter
arcticus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ILE A 400
TRP A 398
ALA A 473
LEU A 494
LEU A 498
 None
 1.27A 4pbhA-3hn7A:
undetectable		 4pbhA-3hn7A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq0 CATECHOL
2,3-DIOXYGENASE

(Pseudomonas
alkylphenolica) 		PF00903
(Glyoxalase) 		5 ILE A 256
THR A 255
HIS A 248
ASP A 294
LEU A 293
 None
 1.26A 4pbhA-3hq0A:
undetectable		 4pbhA-3hq0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T

(Saccharomyces
cerevisiae) 		PF00149
(Metallophos)
PF08321
(PPP5) 		5 ILE A 430
ALA A 348
LEU A 427
LEU A 350
PHE A 373
 None
 1.34A 4pbhA-3icfA:
undetectable		 4pbhA-3icfA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lso PUTATIVE MEMBRANE
ANCHORED PROTEIN

(Corynebacterium
diphtheriae) 		PF16640
(Big_3_5) 		5 ILE B 140
ALA B  87
LEU B 138
LEU B 164
PHE B  73
 None
 1.34A 4pbhA-3lsoB:
undetectable		 4pbhA-3lsoB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacteroides
thetaiotaomicron) 		PF08543
(Phos_pyr_kin) 		5 ILE A 230
THR A 231
THR A 143
LEU A 234
LEU A 107
 None
 1.27A 4pbhA-3mbhA:
undetectable		 4pbhA-3mbhA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my9 MUCONATE
CYCLOISOMERASE

(Azorhizobium
caulinodans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 221
THR A 242
ALA A 215
LEU A 195
LEU A 180
 None
 1.25A 4pbhA-3my9A:
undetectable		 4pbhA-3my9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndo DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Mycolicibacterium
smegmatis) 		PF01791
(DeoC) 		5 THR A  91
ALA A  41
ARG A 211
ASP A  14
PHE A  40
 None
 1.12A 4pbhA-3ndoA:
undetectable		 4pbhA-3ndoA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ILE A 127
THR A 123
ALA A  76
LEU A 124
ASP A  79
 None
 1.16A 4pbhA-3pdsA:
undetectable		 4pbhA-3pdsA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8d DNA REPAIR PROTEIN
RECO

(Escherichia
coli) 		PF02565
(RecO_C)
PF11967
(RecO_N) 		5 ILE A  84
THR A  85
THR A 126
ALA A 130
ARG A 132
 None
 0.99A 4pbhA-3q8dA:
undetectable		 4pbhA-3q8dA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsg NAD-BINDING
PHOSPHOGLUCONATE
DEHYDROGENASE-LIKE
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 ILE A  15
ALA A  90
LEU A  19
LEU A   3
PHE A 144
 None
 1.17A 4pbhA-3qsgA:
undetectable		 4pbhA-3qsgA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		5 ILE A 535
ALA A 524
LEU A 536
LEU A 600
PHE A 522
 None
 0.90A 4pbhA-3r75A:
undetectable		 4pbhA-3r75A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8r TRANSALDOLASE

(Bacillus
subtilis) 		PF00923
(TAL_FSA) 		5 THR A  26
ALA A 164
ARG A 133
LEU A  31
PHE A 130
 GOL  A 221 ( 4.8A)
GOL  A 221 (-3.4A)
SO4  A 301 (-4.0A)
None
GOL  A 221 (-4.1A)
 1.21A 4pbhA-3r8rA:
undetectable		 4pbhA-3r8rA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8r TRANSALDOLASE

(Bacillus
subtilis) 		PF00923
(TAL_FSA) 		5 THR A  26
THR A 108
ALA A 164
ARG A 133
PHE A 130
 GOL  A 221 ( 4.8A)
None
GOL  A 221 (-3.4A)
SO4  A 301 (-4.0A)
GOL  A 221 (-4.1A)
 1.07A 4pbhA-3r8rA:
undetectable		 4pbhA-3r8rA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7v MAJOR CAPSID PROTEIN
VP1

(Human
polyomavirus 3) 		PF00718
(Polyoma_coat) 		5 ILE A 253
THR A 133
LEU A 255
LEU A 128
PHE A 293
 None
 1.03A 4pbhA-3s7vA:
undetectable		 4pbhA-3s7vA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skq MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
38

(Saccharomyces
cerevisiae) 		PF07766
(LETM1) 		5 ILE A 346
HIS A 238
ALA A 370
LEU A 340
LEU A 388
 None
 1.27A 4pbhA-3skqA:
undetectable		 4pbhA-3skqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
ulcerans) 		PF13561
(adh_short_C2) 		5 ILE A  68
THR A  74
ALA A 130
LEU A  11
PHE A 142
 None
 1.19A 4pbhA-3svtA:
undetectable		 4pbhA-3svtA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8i PURINE NUCLEOSIDASE,
(IUNH-2)

(Sulfolobus
solfataricus) 		PF01156
(IU_nuc_hydro) 		5 ILE A 244
THR A 241
THR A 182
ARG A   2
LEU A 119
 None
 1.03A 4pbhA-3t8iA:
undetectable		 4pbhA-3t8iA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgw V-TYPE ATP SYNTHASE
BETA CHAIN

(Methanosarcina
mazei) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 ILE A 249
ALA A 181
ARG A 225
LEU A 283
LEU A 228
 None
 1.32A 4pbhA-3tgwA:
undetectable		 4pbhA-3tgwA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akx EXOU

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		5 ILE B 503
THR B 504
THR B  77
LEU B 485
LEU B 493
 None
 1.24A 4pbhA-4akxB:
undetectable		 4pbhA-4akxB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 ILE A 296
THR A 338
THR A 279
LEU A 340
PHE A 321
 None
 1.21A 4pbhA-4b9yA:
undetectable		 4pbhA-4b9yA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 ILE A 299
THR A 424
ALA A 429
LEU A 391
LEU A 444
 None
 1.46A 4pbhA-4bjpA:
undetectable		 4pbhA-4bjpA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 ILE A 498
THR A 494
ALA A 313
LEU A 470
LEU A 411
 None
 1.47A 4pbhA-4c02A:
undetectable		 4pbhA-4c02A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger) 		PF01979
(Amidohydro_1) 		5 ILE A 373
THR A 372
ALA A 409
LEU A 325
LEU A 413
 None
 1.36A 4pbhA-4c60A:
undetectable		 4pbhA-4c60A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d59 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)

(Clostridioides
difficile) 		PF00112
(Peptidase_C1) 		5 ILE A 493
THR A 494
LEU A 367
LEU A 421
PHE A 358
 None
 1.18A 4pbhA-4d59A:
undetectable		 4pbhA-4d59A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efo SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		no annotation 5 ILE A 379
HIS A 336
ALA A 332
ARG A 365
LEU A 359
 None
 1.34A 4pbhA-4efoA:
undetectable		 4pbhA-4efoA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egt MAJOR CAPSID PROTEIN
VP60

(Rabbit
hemorrhagic
disease virus) 		PF00915
(Calici_coat) 		5 ILE A 461
THR A 538
LEU A 264
LEU A 517
PHE A 567
 None
 1.37A 4pbhA-4egtA:
undetectable		 4pbhA-4egtA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 379
HIS A 336
ALA A 332
ARG A 365
LEU A 359
 None
 1.31A 4pbhA-4eutA:
undetectable		 4pbhA-4eutA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		5 ILE A 127
THR A 123
ALA A  76
LEU A 124
ASP A  79
 None
 1.18A 4pbhA-4gbrA:
undetectable		 4pbhA-4gbrA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Eubacterium
ventriosum) 		PF13306
(LRR_5) 		5 ILE A 375
ALA A 382
LEU A 352
LEU A 332
PHE A 383
 None
EDO  A 509 (-4.5A)
None
None
None
 1.33A 4pbhA-4h09A:
undetectable		 4pbhA-4h09A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Eubacterium
ventriosum) 		PF13306
(LRR_5) 		5 ILE A 375
THR A 354
ALA A 382
LEU A 352
PHE A 383
 None
None
EDO  A 509 (-4.5A)
None
None
 1.29A 4pbhA-4h09A:
undetectable		 4pbhA-4h09A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfu HEMAGGLUTININ HA1

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 ILE A  66
TRP A  84
LEU A 108
LEU A 111
PHE A 116
 None
 1.42A 4pbhA-4hfuA:
undetectable		 4pbhA-4hfuA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		5 THR A  86
HIS A  63
THR A 135
ALA A  66
LEU A  45
 None
None
None
NAD  A 403 (-3.3A)
NAD  A 403 (-3.7A)
 1.38A 4pbhA-4id9A:
undetectable		 4pbhA-4id9A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ini HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL

(Homo sapiens) 		PF01230
(HIT) 		5 ILE A 150
ALA A 103
LEU A 114
ASP A 107
LEU A 110
 None
 1.39A 4pbhA-4iniA:
undetectable		 4pbhA-4iniA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuw NEUTRAL
ENDOPEPTIDASE

(Lactobacillus
rhamnosus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 THR A 364
TRP A 499
ALA A 488
LEU A 360
PHE A 483
 None
 1.35A 4pbhA-4iuwA:
undetectable		 4pbhA-4iuwA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
knowlesi) 		PF08241
(Methyltransf_11) 		5 ILE A  45
THR A  42
THR A 156
LEU A  46
ASP A  59
 None
None
None
None
SAM  A 301 ( 4.9A)
 1.36A 4pbhA-4iv8A:
undetectable		 4pbhA-4iv8A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ILE A1127
THR A1123
ALA A1076
LEU A1124
ASP A1079
 None
 1.18A 4pbhA-4ldeA:
undetectable		 4pbhA-4ldeA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		5 ILE A  19
THR A  20
ARG A 260
LEU A  23
LEU A 218
 None
 1.47A 4pbhA-4m9dA:
undetectable		 4pbhA-4m9dA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
vivax) 		PF13649
(Methyltransf_25) 		5 ILE A  44
THR A  41
THR A 155
LEU A  45
ASP A  58
 None
None
None
None
SAM  A 301 ( 4.6A)
 1.30A 4pbhA-4mwzA:
undetectable		 4pbhA-4mwzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofy PROTEIN SYG-2

(Caenorhabditis
elegans) 		PF08205
(C2-set_2)
PF13927
(Ig_3) 		5 ILE D 254
ALA D 297
ARG D 241
ASP D 250
LEU D 246
 None
 1.44A 4pbhA-4ofyD:
undetectable		 4pbhA-4ofyD:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 5 ILE A 326
THR A 351
HIS A 384
TRP A 343
LEU A 387
 None
 1.33A 4pbhA-4oj5A:
undetectable		 4pbhA-4oj5A:
19.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE

(Ruegeria
pomeroyi) 		PF03480
(DctP) 		12 ILE A  34
THR A  35
HIS A  39
TRP A  41
THR A  91
ALA A 147
ARG A 150
ARG A 170
LEU A 193
ASP A 211
LEU A 214
PHE A 235
 DHB  A 401 ( 4.8A)
DHB  A 401 (-4.2A)
DHB  A 401 (-3.8A)
DHB  A 401 (-2.9A)
DHB  A 401 (-4.2A)
DHB  A 401 (-2.8A)
DHB  A 401 (-2.8A)
DHB  A 401 (-3.0A)
DHB  A 401 (-4.8A)
DHB  A 401 (-2.9A)
DHB  A 401 (-4.5A)
DHB  A 401 (-4.5A)
 0.10A 4pbhA-4pafA:
55.6		 4pbhA-4pafA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyh PHOSPHOGLUCAN
PHOSPHATASE DSP4,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00782
(DSPc)
PF16561
(AMPK1_CBM) 		5 ILE A 246
THR A 245
ARG A 351
LEU A 352
LEU A 359
 None
 1.33A 4pbhA-4pyhA:
undetectable		 4pbhA-4pyhA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyh PHOSPHOGLUCAN
PHOSPHATASE DSP4,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00782
(DSPc)
PF16561
(AMPK1_CBM) 		5 ILE A 246
THR A 245
THR A 250
ARG A 351
LEU A 359
 None
 1.23A 4pbhA-4pyhA:
undetectable		 4pbhA-4pyhA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF13649
(Methyltransf_25) 		5 ILE A  47
THR A  44
THR A 158
LEU A  48
ASP A  61
 None
None
None
None
SAH  A 302 ( 4.6A)
 1.25A 4pbhA-4r6wA:
undetectable		 4pbhA-4r6wA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo sapiens) 		PF13489
(Methyltransf_23) 		5 THR A 172
THR A 295
LEU A 175
ASP A 193
LEU A 201
 SAM  A 401 (-3.7A)
SAM  A 401 (-4.6A)
None
None
None
 1.45A 4pbhA-4rfqA:
undetectable		 4pbhA-4rfqA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 ILE A2190
HIS A2185
ALA A2216
LEU A2238
PHE A2213
 None
 1.06A 4pbhA-4rh7A:
undetectable		 4pbhA-4rh7A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmk PROTEIN (THYMIDYLATE
KINASE)

(Escherichia
coli) 		PF02223
(Thymidylate_kin) 		5 ILE A 200
THR A 203
THR A  26
LEU A 137
LEU A 135
 None
 1.43A 4pbhA-4tmkA:
undetectable		 4pbhA-4tmkA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		5 ILE B 295
ALA B 331
LEU B 298
LEU B 302
PHE B 311
 None
 1.27A 4pbhA-4um8B:
undetectable		 4pbhA-4um8B:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis) 		PF01494
(FAD_binding_3) 		5 ILE A 292
THR A  50
THR A  99
ALA A  91
PHE A  63
 None
 1.38A 4pbhA-4x4jA:
undetectable		 4pbhA-4x4jA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydo UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF00432
(Prenyltrans) 		5 ILE B 447
ALA B 375
LEU B 444
LEU B 440
PHE B 359
 None
 1.36A 4pbhA-4ydoB:
undetectable		 4pbhA-4ydoB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF09295
(ChAPs) 		5 ILE B 512
THR B 516
ARG B 625
ASP B 596
LEU B 599
 None
 1.37A 4pbhA-4yg8B:
undetectable		 4pbhA-4yg8B:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk3 SERPIN B3

(Homo sapiens) 		PF00079
(Serpin) 		5 ILE A  32
THR A  35
ALA A   7
LEU A  88
PHE A  59
 None
 1.20A 4pbhA-4zk3A:
undetectable		 4pbhA-4zk3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5r GASDERMIN-A3

(Mus musculus) 		PF04598
(Gasdermin) 		5 THR A 231
ARG A 145
LEU A  63
LEU A 134
PHE A 232
 None
 1.43A 4pbhA-5b5rA:
undetectable		 4pbhA-5b5rA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fis EXD1

(Bombyx mori) 		PF01612
(DNA_pol_A_exo1) 		5 ILE B 161
ALA B 153
LEU B 135
LEU B 133
PHE B 102
 None
 1.34A 4pbhA-5fisB:
undetectable		 4pbhA-5fisB:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		5 ILE A 278
ALA A 244
LEU A 281
LEU A 204
PHE A 245
 None
 1.44A 4pbhA-5g5zA:
undetectable		 4pbhA-5g5zA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 THR A 148
THR A 145
LEU A 136
LEU A 125
PHE A 118
 None
 1.31A 4pbhA-5gz8A:
undetectable		 4pbhA-5gz8A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik8 LAMININ SUBUNIT
ALPHA-2

(Mus musculus) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2) 		5 THR A2892
HIS A2806
THR A2811
ALA A2802
LEU A2886
 None
 1.45A 4pbhA-5ik8A:
undetectable		 4pbhA-5ik8A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 142
ALA A 199
LEU A 152
ASP A 196
LEU A 124
 None
 1.49A 4pbhA-5j5tA:
undetectable		 4pbhA-5j5tA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5km5 HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL

(Homo sapiens) 		PF01230
(HIT) 		5 ILE A 150
ALA A 103
LEU A 114
ASP A 107
LEU A 110
 None
 1.41A 4pbhA-5km5A:
undetectable		 4pbhA-5km5A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liq NICKING ENDONUCLEASE
N.BSPD6I

(Bacillus sp.
(in: Bacteria)) 		PF09491
(RE_AlwI) 		5 ILE A 156
TRP A   7
THR A 241
LEU A 151
LEU A 144
 None
 1.42A 4pbhA-5liqA:
undetectable		 4pbhA-5liqA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz8 ALDEHYDE
DEHYDROGENASE 21

(Physcomitrella
patens) 		PF00171
(Aldedh) 		5 ILE A 123
THR A 122
ALA A 182
LEU A  93
LEU A 206
 None
 1.34A 4pbhA-5mz8A:
undetectable		 4pbhA-5mz8A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nem INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		5 ILE B 292
ALA B 328
LEU B 295
LEU B 299
PHE B 308
 None
 1.26A 4pbhA-5nemB:
undetectable		 4pbhA-5nemB:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 5 ILE A  69
ALA A 129
LEU A 148
ASP A 191
LEU A 133
 None
 1.43A 4pbhA-5tvtA:
undetectable		 4pbhA-5tvtA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1

(Homo sapiens) 		PF00400
(WD40)
PF00931
(NB-ARC) 		5 ILE A 813
HIS A 827
LEU A 769
ASP A 754
LEU A 757
 None
 1.49A 4pbhA-5wveA:
undetectable		 4pbhA-5wveA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1e ICMS

(Legionella
pneumophila) 		PF12608
(T4bSS_IcmS) 		5 ILE A  97
THR A 106
LEU A  96
LEU A 108
PHE A  33
 None
 1.40A 4pbhA-5x1eA:
undetectable		 4pbhA-5x1eA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6am0 KLLA0F23980P

(Kluyveromyces
lactis) 		no annotation 5 ILE A 229
ALA A 108
LEU A 209
LEU A 119
PHE A 110
 None
 1.33A 4pbhA-6am0A:
undetectable		 4pbhA-6am0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 5 ILE A 793
THR A 792
ALA A 757
LEU A 789
PHE A 727
 None
 1.03A 4pbhA-6bv2A:
undetectable		 4pbhA-6bv2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 5 ILE A2679
ALA A2690
LEU A2723
ASP A2731
LEU A2734
 None
 1.47A 4pbhA-6ez8A:
undetectable		 4pbhA-6ez8A:
undetectable