SIMILAR PATTERNS OF AMINO ACIDS FOR 4P7N_A_GCSA701

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 ASP A  63
MET A 372
TRP A 811
TYR A 363
 None
None
NAG  A1912 ( 4.8A)
None
 1.29A 4p7nA-2vcaA:
11.5		 4p7nA-2vcaA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb7 INSECTICIDAL
DELTA-ENDOTOXIN
CRY8EA1

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 TYR A  96
ASP A 212
MET A 290
TYR A 288
 None
 1.48A 4p7nA-3eb7A:
0.0		 4p7nA-3eb7A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 TYR A 285
ASP A 261
TRP A 213
TYR A 266
 None
 1.40A 4p7nA-3fefA:
0.3		 4p7nA-3fefA:
23.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Escherichia
coli) 		PF14883
(GHL13) 		5 TYR A 432
ASP A 466
MET A 572
TRP A 613
TYR A 645
 None
 0.27A 4p7nA-4p7lA:
60.7		 4p7nA-4p7lA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dk3 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B 373
ASP B 280
TRP B 313
TYR B 319
 None
None
SO4  B 504 (-4.5A)
None
 1.21A 4p7nA-5dk3B:
0.0		 4p7nA-5dk3B:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y29 INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 TYR A1646
ASP A1665
TRP A1623
TYR A1624
 None
 1.47A 4p7nA-5y29A:
17.8		 4p7nA-5y29A:
12.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6au1 PUTATIVE HEMIN
STORAGE PROTEIN

(Bordetella
bronchiseptica) 		no annotation 4 ASP A 474
MET A 581
TRP A 619
TYR A 648
 EDO  A 705 (-3.3A)
None
None
None
 0.39A 4p7nA-6au1A:
50.3		 4p7nA-6au1A:
59.76