SIMILAR PATTERNS OF AMINO ACIDS FOR 4P6X_I_HCYI900_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a59 CITRATE SYNTHASE

(Antarctic
bacterium
DS2-3R) 		PF00285
(Citrate_synt) 		3 MET A 124
MET A 180
TYR A  50
 None
 0.93A 4p6xI-1a59A:
0.0		 4p6xI-1a59A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amo NADPH-CYTOCHROME
P450 REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 MET A 301
MET A 541
TYR A 456
 None
None
FAD  A 750 (-4.3A)
 1.34A 4p6xI-1amoA:
0.0		 4p6xI-1amoA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)

(Hordeum vulgare) 		PF01373
(Glyco_hydro_14) 		3 MET A 439
MET A 494
TYR A 389
 None
 1.11A 4p6xI-1b1yA:
0.0		 4p6xI-1b1yA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)

(Trypanosoma
cruzi) 		PF00155
(Aminotran_1_2) 		3 MET A 222
MET A 323
TYR A 345
 LLP  A 253 ( 3.7A)
None
None
 1.34A 4p6xI-1bw0A:
0.0		 4p6xI-1bw0A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cn3 COAT PROTEIN VP1

(Polyomavirus
sp.) 		PF00718
(Polyoma_coat) 		3 MET A 100
MET A  57
TYR A 222
 None
 1.24A 4p6xI-1cn3A:
0.0		 4p6xI-1cn3A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		3 MET A 431
MET A 440
TYR A 375
 None
 1.17A 4p6xI-1dgjA:
0.0		 4p6xI-1dgjA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 MET A 477
MET A 481
TYR A 327
 None
 1.21A 4p6xI-1dlcA:
1.2		 4p6xI-1dlcA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e7s GDP-FUCOSE
SYNTHETASE

(Escherichia
coli) 		PF01370
(Epimerase) 		3 MET A  14
MET A 162
TYR A 167
 NAP  A1317 (-3.0A)
None
None
 1.19A 4p6xI-1e7sA:
0.0		 4p6xI-1e7sA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ilo CONSERVED
HYPOTHETICAL PROTEIN
MTH895

(Methanothermobacter
thermautotrophicus) 		PF13192
(Thioredoxin_3) 		3 MET A  63
MET A  16
TYR A   7
 None
 1.27A 4p6xI-1iloA:
0.0		 4p6xI-1iloA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		3 MET A 275
MET A 158
TYR A 260
 None
 1.24A 4p6xI-1l1lA:
undetectable		 4p6xI-1l1lA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		3 MET A 180
MET A 166
TYR A 160
 2FA  A 306 (-3.8A)
None
None
 0.73A 4p6xI-1pk9A:
undetectable		 4p6xI-1pk9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ty4 APOPTOSIS REGULATOR
CED-9
EGG LAYING DEFECTIVE
EGL-1, PROGRAMMED
CELL DEATH ACTIVATOR

(Caenorhabditis
elegans) 		PF00452
(Bcl-2)
PF02180
(BH4)
PF11430
(EGL-1) 		3 MET A 119
MET C  61
TYR A 168
 None
 1.23A 4p6xI-1ty4A:
undetectable		 4p6xI-1ty4A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzz PROBABLE
ENDOGLUCANASE

(Komagataeibacter
xylinus) 		PF01270
(Glyco_hydro_8) 		3 MET A 150
MET A 201
TYR A 179
 None
 1.33A 4p6xI-1wzzA:
undetectable		 4p6xI-1wzzA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2o HYPOTHETICAL PROTEIN
BT3146

(Bacteroides
thetaiotaomicron) 		no annotation 3 MET A 226
MET A 157
TYR A 166
 None
 0.85A 4p6xI-2a2oA:
undetectable		 4p6xI-2a2oA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14

(Homo sapiens) 		PF00443
(UCH) 		3 MET A 180
MET A 206
TYR A 150
 None
 1.26A 4p6xI-2aynA:
undetectable		 4p6xI-2aynA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b44 GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM

(Staphylococcus
aureus) 		PF01551
(Peptidase_M23) 		3 MET A 217
MET A 259
TYR A 224
 None
 1.27A 4p6xI-2b44A:
undetectable		 4p6xI-2b44A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dao TRANSCRIPTION FACTOR
ETV6

(Homo sapiens) 		PF00178
(Ets) 		3 MET A  97
MET A  90
TYR A  16
 None
 1.32A 4p6xI-2daoA:
undetectable		 4p6xI-2daoA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		3 MET A 165
MET A 183
TYR A 158
 None
 0.98A 4p6xI-2dw6A:
undetectable		 4p6xI-2dw6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 MET A 298
MET A 307
TYR A  96
 None
 1.21A 4p6xI-2eklA:
undetectable		 4p6xI-2eklA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE

(Enterococcus
faecalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		3 MET A   1
MET A  94
TYR A 100
 None
 1.04A 4p6xI-2ew2A:
undetectable		 4p6xI-2ew2A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 MET A1024
MET A 984
TYR A 992
 None
 1.42A 4p6xI-2gjtA:
undetectable		 4p6xI-2gjtA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qor GUANYLATE KINASE

(Plasmodium
vivax) 		PF00625
(Guanylate_kin) 		3 MET A 102
MET A 158
TYR A 121
 None
 1.19A 4p6xI-2qorA:
undetectable		 4p6xI-2qorA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs8 XAA-PRO DIPEPTIDASE

(Alteromonas
macleodii) 		PF01979
(Amidohydro_1) 		3 MET A  68
MET A 230
TYR A 273
 None
 1.42A 4p6xI-2qs8A:
undetectable		 4p6xI-2qs8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv5 UNCHARACTERIZED
PROTEIN ATU2773

(Agrobacterium
fabrum) 		PF04748
(Polysacc_deac_2) 		3 MET A 217
MET A 275
TYR A 165
 None
 1.12A 4p6xI-2qv5A:
undetectable		 4p6xI-2qv5A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		3 MET A 477
MET A 536
TYR A 449
 None
 1.18A 4p6xI-2qzpA:
undetectable		 4p6xI-2qzpA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r09 CYTOHESIN-3

(Mus musculus) 		PF00169
(PH)
PF01369
(Sec7) 		3 MET A 199
MET A 169
TYR A 385
 PE5  A 407 ( 3.9A)
None
PE5  A 407 (-3.7A)
 1.17A 4p6xI-2r09A:
undetectable		 4p6xI-2r09A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		3 MET G 658
MET G1011
TYR G 624
 None
 1.20A 4p6xI-2uv8G:
undetectable		 4p6xI-2uv8G:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w31 GLOBIN

(Geobacter
sulfurreducens) 		PF11563
(Protoglobin) 		3 MET A 146
MET A   1
TYR A  82
 HEM  A 200 ( 3.7A)
None
None
 1.38A 4p6xI-2w31A:
2.5		 4p6xI-2w31A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		3 MET A 112
MET A  82
TYR A 165
 None
 1.41A 4p6xI-2ww2A:
undetectable		 4p6xI-2ww2A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1o GELSOLIN NANOBODY

(Lama glama) 		PF07686
(V-set) 		3 MET A  34
MET A 106
TYR A 111
 None
 1.22A 4p6xI-2x1oA:
undetectable		 4p6xI-2x1oA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 3 MET A 328
MET A 621
TYR A 264
 None
 1.32A 4p6xI-2yr5A:
undetectable		 4p6xI-2yr5A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		3 MET A 374
MET A 411
TYR A 418
 None
 1.39A 4p6xI-3a5iA:
undetectable		 4p6xI-3a5iA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl3 ORF K13

(Human
gammaherpesvirus
8) 		PF01335
(DED) 		3 MET A 171
MET A  88
TYR A  94
 None
 1.24A 4p6xI-3cl3A:
undetectable		 4p6xI-3cl3A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh1 TRNA-SPECIFIC
ADENOSINE DEAMINASE
2

(Homo sapiens) 		PF14437
(MafB19-deam) 		3 MET A  30
MET A  48
TYR A 158
 None
 1.39A 4p6xI-3dh1A:
undetectable		 4p6xI-3dh1A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hqi SPECKLE-TYPE POZ
PROTEIN

(Homo sapiens) 		PF00651
(BTB)
PF00917
(MATH) 		3 MET A 255
MET A 288
TYR A 280
 None
 1.19A 4p6xI-3hqiA:
undetectable		 4p6xI-3hqiA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htm SPECKLE-TYPE POZ
PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		3 MET A 255
MET A 288
TYR A 280
 None
 1.25A 4p6xI-3htmA:
undetectable		 4p6xI-3htmA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4t DIPHTHINE SYNTHASE

(Entamoeba
histolytica) 		PF00590
(TP_methylase) 		3 MET A 214
MET A 218
TYR A 268
 None
 1.11A 4p6xI-3i4tA:
undetectable		 4p6xI-3i4tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibh SACCHAROMYCES
CEREVISIAE GTT2

(Saccharomyces
cerevisiae) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		3 MET A 163
MET A 116
TYR A 213
 None
 1.28A 4p6xI-3ibhA:
undetectable		 4p6xI-3ibhA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 3 MET A  87
MET A 122
TYR A 187
 None
 1.25A 4p6xI-3j4uA:
undetectable		 4p6xI-3j4uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		3 MET A 296
MET A 300
TYR A 283
 None
 1.37A 4p6xI-3koyA:
undetectable		 4p6xI-3koyA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7

(Homo sapiens) 		PF00620
(RhoGAP) 		3 MET A1099
MET A1128
TYR A1153
 None
 1.17A 4p6xI-3kuqA:
undetectable		 4p6xI-3kuqA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		3 MET A   1
MET A 220
TYR A 128
 None
 1.42A 4p6xI-3mmtA:
undetectable		 4p6xI-3mmtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a DIHEME CYTOCHROME C
NAPB
PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF03892
(NapB)
PF04879
(Molybdop_Fe4S4) 		3 MET B   6
MET A 458
TYR A 485
 None
 1.16A 4p6xI-3o5aB:
undetectable		 4p6xI-3o5aB:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odh OKRAI ENDONUCLEASE

(Oceanobacter
kriegii) 		PF02923
(BamHI) 		3 MET A 119
MET A  90
TYR A 166
 None
 1.20A 4p6xI-3odhA:
undetectable		 4p6xI-3odhA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnd THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE

(Salmonella
enterica) 		PF02424
(ApbE) 		3 MET A  41
MET A  85
TYR A 189
 FAD  A 500 (-3.7A)
None
SO4  A 360 (-4.8A)
 0.92A 4p6xI-3pndA:
undetectable		 4p6xI-3pndA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q7z BETA-LACTAMASE
REGULATORY PROTEIN
BLAR1

(Staphylococcus
aureus) 		PF00905
(Transpeptidase) 		3 MET A 368
MET A 579
TYR A 544
 None
 1.30A 4p6xI-3q7zA:
undetectable		 4p6xI-3q7zA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh9 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(NAD(P)(+))

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		3 MET A   1
MET A 321
TYR A  30
 None
 1.22A 4p6xI-3rh9A:
undetectable		 4p6xI-3rh9A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 3 MET N 376
MET N 388
TYR N 425
 None
 0.90A 4p6xI-3rkoN:
undetectable		 4p6xI-3rkoN:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 MET A 515
MET A 445
TYR A 456
 None
 1.29A 4p6xI-3sghA:
undetectable		 4p6xI-3sghA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shs HOC HEAD OUTER
CAPSID PROTEIN

(Escherichia
virus RB49) 		no annotation 3 MET A 184
MET A 180
TYR A 280
 None
 1.15A 4p6xI-3shsA:
undetectable		 4p6xI-3shsA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB

(Methanosarcina
barkeri) 		PF04055
(Radical_SAM) 		3 MET A 150
MET A 144
TYR A 121
 None
MD0  A 993 ( 4.5A)
None
 1.25A 4p6xI-3t7vA:
undetectable		 4p6xI-3t7vA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb5 METHIONINE
AMINOPEPTIDASE

(Enterococcus
faecalis) 		PF00557
(Peptidase_M24) 		3 MET A  95
MET A 203
TYR A 110
 None
 1.39A 4p6xI-3tb5A:
undetectable		 4p6xI-3tb5A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0j TYPE III EFFECTOR
HOPU1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 3 MET B 144
MET B 153
TYR B  82
 None
 1.16A 4p6xI-3u0jB:
undetectable		 4p6xI-3u0jB:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u80 3-DEHYDROQUINATE
DEHYDRATASE, TYPE II

(Bifidobacterium
longum) 		PF01220
(DHquinase_II) 		3 MET A  57
MET A  91
TYR A  81
 None
 1.39A 4p6xI-3u80A:
undetectable		 4p6xI-3u80A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		3 MET A 794
MET A 741
TYR A 392
 None
 1.07A 4p6xI-3ummA:
undetectable		 4p6xI-3ummA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		3 MET D 194
MET D 316
TYR D 263
 None
 1.33A 4p6xI-3w3aD:
undetectable		 4p6xI-3w3aD:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acv PROPHAGE LAMBDALM01,
ANTIGEN B

(Listeria
monocytogenes) 		PF16807
(DUF5072) 		3 MET B  42
MET B  16
TYR B  58
 None
 1.37A 4p6xI-4acvB:
undetectable		 4p6xI-4acvB:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN

(Pyrococcus sp.
ST04) 		no annotation 3 MET A 476
MET A 442
TYR A 494
 None
 1.07A 4p6xI-4cmrA:
undetectable		 4p6xI-4cmrA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eoz SPECKLE-TYPE POZ
PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		3 MET A 255
MET A 288
TYR A 280
 None
 1.23A 4p6xI-4eozA:
undetectable		 4p6xI-4eozA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		3 MET A1246
MET A1198
TYR A1236
 None
 1.33A 4p6xI-4f0gA:
undetectable		 4p6xI-4f0gA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 MET A1015
MET A1000
TYR A1022
 None
 1.29A 4p6xI-4f4cA:
undetectable		 4p6xI-4f4cA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk8 HISTIDINOL-PHOSPHATA
SE

(Lactococcus
lactis) 		PF02811
(PHP) 		3 MET A  50
MET A  82
TYR A 117
 GK8  A 305 ( 3.9A)
None
GK8  A 305 ( 3.9A)
 1.44A 4p6xI-4gk8A:
undetectable		 4p6xI-4gk8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl3 PUTATIVE
GLUCOAMYLASE

(Bacteroides
uniformis) 		PF10091
(Glycoamylase) 		3 MET A 412
MET A 155
TYR A 281
 None
 1.32A 4p6xI-4gl3A:
undetectable		 4p6xI-4gl3A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8z SPECKLE-TYPE POZ
PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		3 MET A 255
MET A 288
TYR A 280
 None
 1.27A 4p6xI-4j8zA:
undetectable		 4p6xI-4j8zA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4km3 METHIONINE
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF00557
(Peptidase_M24) 		3 MET A  99
MET A 234
TYR A 141
 None
 1.30A 4p6xI-4km3A:
undetectable		 4p6xI-4km3A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npb PROTEIN DISULFIDE
ISOMERASE II

(Yersinia pestis) 		PF10411
(DsbC_N)
PF13098
(Thioredoxin_2) 		3 MET A 174
MET A 163
TYR A 141
 None
 1.37A 4p6xI-4npbA:
undetectable		 4p6xI-4npbA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pot VP1

(Human
polyomavirus 9) 		PF00718
(Polyoma_coat) 		3 MET A 123
MET A  56
TYR A  51
 None
 0.99A 4p6xI-4potA:
undetectable		 4p6xI-4potA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhm ARGINASE

(Trypanosoma
brucei) 		PF00491
(Arginase) 		3 MET A  35
MET A  84
TYR A 269
 None
 1.35A 4p6xI-4rhmA:
undetectable		 4p6xI-4rhmA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax) 		PF01979
(Amidohydro_1) 		3 MET A 173
MET A 155
TYR A  83
 None
 1.14A 4p6xI-4wgxA:
undetectable		 4p6xI-4wgxA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnx NETRIN-4

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		3 MET A  38
MET A 294
TYR A 126
 None
 1.01A 4p6xI-4wnxA:
undetectable		 4p6xI-4wnxA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 MET A 661
MET A 935
TYR A 644
 None
 1.17A 4p6xI-4wz9A:
undetectable		 4p6xI-4wz9A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0r INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX2

(Homo sapiens) 		no annotation 3 MET B 155
MET B 112
TYR B 212
 None
 1.34A 4p6xI-4x0rB:
undetectable		 4p6xI-4x0rB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x7m TARM

(Staphylococcus
aureus) 		PF00534
(Glycos_transf_1) 		3 MET A 327
MET A 409
TYR A 355
 None
 1.21A 4p6xI-4x7mA:
undetectable		 4p6xI-4x7mA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb3 GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Streptococcus
mutans) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 MET A 356
MET A 395
TYR A 349
 None
 1.28A 4p6xI-4xb3A:
undetectable		 4p6xI-4xb3A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		3 MET A 350
MET A 342
TYR A 364
 None
 1.40A 4p6xI-4xhjA:
undetectable		 4p6xI-4xhjA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyb FORMATE
DEHYDROGENASE

(Granulicella
mallensis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 MET A 193
MET A 245
TYR A 279
 None
 1.43A 4p6xI-4xybA:
undetectable		 4p6xI-4xybA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7c S-CRYSTALLIN OCTVUS4

(Octopus
vulgaris) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 MET A 162
MET A 143
TYR A 170
 None
 1.18A 4p6xI-5b7cA:
undetectable		 4p6xI-5b7cA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8s GUANINE-N7
METHYLTRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		3 MET B 315
MET B 500
TYR B 491
 None
 1.23A 4p6xI-5c8sB:
undetectable		 4p6xI-5c8sB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1p ATP-DEPENDENT RNA
LIGASE

(Methanothermobacter
thermautotrophicus) 		PF09414
(RNA_ligase) 		3 MET A 235
MET A  98
TYR A 247
 None
APK  A  97 ( 4.2A)
None
 1.24A 4p6xI-5d1pA:
undetectable		 4p6xI-5d1pA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 MET A 484
MET A 365
TYR A 227
 None
 1.25A 4p6xI-5g2vA:
undetectable		 4p6xI-5g2vA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjn LYSINE/ORNITHINE
DECARBOXYLASE

(Selenomonas
ruminantium) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 MET A  90
MET A 124
TYR A 108
 None
 1.44A 4p6xI-5gjnA:
undetectable		 4p6xI-5gjnA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		3 MET F 796
MET F 864
TYR F 782
 None
 1.42A 4p6xI-5gjwF:
undetectable		 4p6xI-5gjwF:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp4 GLUTAMATE
DECARBOXYLASE

(Lactobacillus
brevis) 		no annotation 3 MET C 185
MET C 212
TYR C 216
 None
 1.43A 4p6xI-5gp4C:
undetectable		 4p6xI-5gp4C:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzh ENDO-BETA-1,2-GLUCAN
ASE

(Chitinophaga
pinensis) 		PF10091
(Glycoamylase) 		3 MET A 407
MET A 146
TYR A 274
 None
 1.29A 4p6xI-5gzhA:
undetectable		 4p6xI-5gzhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ica PERIODIC TRYPTOPHAN
PROTEIN 2-LIKE
PROTEIN
PUTATIVE U3 SNORNP
PROTEIN

(Chaetomium
thermophilum) 		PF04003
(Utp12)
PF04192
(Utp21) 		3 MET C1007
MET C 995
TYR D 843
 None
 1.20A 4p6xI-5icaC:
undetectable		 4p6xI-5icaC:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL

(Coccidioides
posadasii) 		PF00579
(tRNA-synt_1b) 		3 MET A 295
MET A 239
TYR A 288
 None
 0.91A 4p6xI-5ijxA:
undetectable		 4p6xI-5ijxA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2m RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN

(Thermococcus
kodakarensis) 		PF08443
(RimK) 		3 MET A  15
MET A 246
TYR A   7
 None
 1.27A 4p6xI-5k2mA:
undetectable		 4p6xI-5k2mA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kov CAPSID POLYPROTEIN
VP90

(Mamastrovirus 1) 		PF12226
(Astro_capsid_p) 		3 MET A 480
MET A 508
TYR A 590
 None
 0.77A 4p6xI-5kovA:
undetectable		 4p6xI-5kovA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		3 MET A 388
MET A 472
TYR A 144
 None
 1.36A 4p6xI-5ktkA:
undetectable		 4p6xI-5ktkA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL

(Bos taurus) 		PF00346
(Complex1_49kDa) 		3 MET D 152
MET D 112
TYR D 108
 None
 1.39A 4p6xI-5lc5D:
undetectable		 4p6xI-5lc5D:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 MET A 287
MET A 360
TYR A 370
 None
 1.21A 4p6xI-5vniA:
undetectable		 4p6xI-5vniA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wez TIR CHAPERONE

(Escherichia
coli) 		no annotation 3 MET A  50
MET A 120
TYR A  83
 None
 1.10A 4p6xI-5wezA:
undetectable		 4p6xI-5wezA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z95 -

(-) 		no annotation 3 MET A 219
MET A  99
TYR A  26
 EGC  A 301 (-3.8A)
None
EGC  A 301 ( 4.7A)
 1.40A 4p6xI-5z95A:
undetectable		 4p6xI-5z95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 3 MET A 166
MET A 113
TYR A 189
 None
 1.23A 4p6xI-6byxA:
undetectable		 4p6xI-6byxA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 3 MET A1018
MET A1022
TYR A1057
 None
 1.40A 4p6xI-6eojA:
undetectable		 4p6xI-6eojA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eot DIPEPTIDYL PEPTIDASE
8

(Homo sapiens) 		no annotation 3 MET A 722
MET A 813
TYR A 787
 None
 1.34A 4p6xI-6eotA:
undetectable		 4p6xI-6eotA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd PROTEASOME SUBUNIT
BETA TYPE-4
PROTEASOME SUBUNIT
BETA TYPE-6

(Rattus
norvegicus) 		no annotation 3 MET 1 153
MET 7  49
TYR 7 106
 None
 1.02A 4p6xI-6epd1:
undetectable		 4p6xI-6epd1:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 3 MET A 499
MET A 440
TYR A 488
 None
EDO  A 806 (-3.5A)
None
 1.15A 4p6xI-6f91A:
undetectable		 4p6xI-6f91A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkq NETRIN-1

(Homo sapiens) 		no annotation 3 MET A 210
MET A 159
TYR A 272
 SO4  A 510 ( 4.4A)
None
None
 1.39A 4p6xI-6fkqA:
undetectable		 4p6xI-6fkqA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 3 MET A  94
MET A  26
TYR A 107
 None
 1.16A 4p6xI-6fuyA:
undetectable		 4p6xI-6fuyA:
14.90