SIMILAR PATTERNS OF AMINO ACIDS FOR 4P6X_I_HCYI900

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A 172
GLY A 176
GLN A 177
LEU A 293
THR A 222
 None
 1.21A 4p6xI-1asoA:
undetectable		 4p6xI-1asoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 LEU A 534
ASN A 537
GLY A 536
GLN A 208
ILE A 337
 OAS  A 530 ( 3.3A)
None
None
None
None
 1.15A 4p6xI-1ebvA:
undetectable		 4p6xI-1ebvA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi) 		PF00365
(PFK) 		5 ASN A 456
GLY A 457
GLN A 197
LEU A  73
ILE A  28
 None
 1.40A 4p6xI-1kzhA:
undetectable		 4p6xI-1kzhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi) 		PF00365
(PFK) 		5 LEU A 455
ASN A 456
GLY A 457
GLN A 197
ILE A  28
 None
 1.44A 4p6xI-1kzhA:
undetectable		 4p6xI-1kzhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 LEU A 182
LEU A  31
MET A 208
THR A 187
PHE A 157
 None
 1.42A 4p6xI-1p88A:
undetectable		 4p6xI-1p88A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfn CONSERVED
HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF05899
(Cupin_3) 		5 LEU A1038
LEU A1028
GLN A1052
ILE A1018
PHE A1023
 None
 1.25A 4p6xI-1sfnA:
undetectable		 4p6xI-1sfnA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlv ORNITHINE
CARBAMOYLTRANSFERASE

(Thermotoga
maritima) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ASN A 149
GLY A 151
LEU A  25
ARG A  22
ILE A 268
 None
 1.27A 4p6xI-1vlvA:
undetectable		 4p6xI-1vlvA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		5 GLY B 234
GLN B 200
GLN B 210
ILE B 367
PHE B 239
 None
 1.23A 4p6xI-1wdwB:
1.1		 4p6xI-1wdwB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zov MONOMERIC SARCOSINE
OXIDASE

(Bacillus sp.
NS-129) 		PF01266
(DAO) 		5 GLY A 263
LEU A 298
MET A 302
THR A  87
PHE A 259
 None
 1.43A 4p6xI-1zovA:
undetectable		 4p6xI-1zovA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 LEU A   7
ASN A   8
GLY A 142
GLN A 171
THR A  92
 None
 1.43A 4p6xI-2ajrA:
undetectable		 4p6xI-2ajrA:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLN A 711
MET A 742
ARG A 752
GLN A 783
MET A 787
 BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
None
BHM  A   1 (-3.6A)
 1.22A 4p6xI-2ax9A:
32.1		 4p6xI-2ax9A:
49.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLY A 708
GLN A 711
MET A 742
ARG A 752
MET A 787
 BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
 0.93A 4p6xI-2ax9A:
32.1		 4p6xI-2ax9A:
49.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 704
ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
 BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
 0.87A 4p6xI-2ax9A:
32.1		 4p6xI-2ax9A:
49.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 704
ASN A 705
GLY A 708
GLN A 711
MET A 742
PHE A 891
 BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
None
 0.92A 4p6xI-2ax9A:
32.1		 4p6xI-2ax9A:
49.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 704
GLN A 711
MET A 742
ARG A 752
GLN A 783
 BHM  A   1 (-4.0A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
None
 1.36A 4p6xI-2ax9A:
32.1		 4p6xI-2ax9A:
49.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7i PUTATIVE LIPOATE
PROTEIN LIGASE

(Thermoplasma
acidophilum) 		PF03099
(BPL_LplA_LipB) 		5 LEU A  36
GLY A   3
LEU A 222
MET A 106
ILE A  24
 None
 1.46A 4p6xI-2c7iA:
undetectable		 4p6xI-2c7iA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2r UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF01255
(Prenyltransf) 		5 LEU A 206
ASN A  15
GLY A  16
LEU A  21
THR A  36
 None
 1.47A 4p6xI-2d2rA:
undetectable		 4p6xI-2d2rA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR

(Mycobacterium
tuberculosis) 		PF02515
(CoA_transf_3) 		5 GLY A 222
LEU A 210
MET A 204
ILE A 242
PHE A 225
 None
 1.23A 4p6xI-2g04A:
undetectable		 4p6xI-2g04A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 216
ASN A 217
GLY A 214
LEU A 150
GLN A 223
 None
 1.40A 4p6xI-2g76A:
undetectable		 4p6xI-2g76A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1q ARGININE KINASE

(Trypanosoma
cruzi) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 ASN A 274
GLY A 276
GLN A  99
LEU A 333
GLN A 307
 None
 1.38A 4p6xI-2j1qA:
undetectable		 4p6xI-2j1qA:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 LEU A  32
ASN A  33
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 115
THR A 208
 1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 ( 3.7A)
1CA  A 247 (-3.4A)
 0.76A 4p6xI-2q3yA:
36.2		 4p6xI-2q3yA:
63.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 LEU A  32
ASN A  33
GLN A  39
MET A  70
LEU A  77
ARG A  80
THR A 208
PHE A 219
 1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 0.60A 4p6xI-2q3yA:
36.2		 4p6xI-2q3yA:
63.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgz HEME OXYGENASE 2

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		5 MET A 158
LEU A  97
MET A 206
THR A  41
PHE A 227
 None
None
None
None
HEM  A 300 (-4.1A)
 1.47A 4p6xI-2rgzA:
undetectable		 4p6xI-2rgzA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE

(Paraburkholderia
xenovorans) 		PF12697
(Abhydrolase_6) 		5 GLY A  19
MET A  82
LEU A  88
ILE A  25
PHE A  23
 None
 1.30A 4p6xI-2ri6A:
undetectable		 4p6xI-2ri6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Thermus
thermophilus) 		PF09488
(Osmo_MPGsynth) 		5 LEU A 229
GLN A 231
LEU A 327
ARG A 224
GLN A 273
 None
 1.39A 4p6xI-2wvlA:
undetectable		 4p6xI-2wvlA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 MET A 467
LEU A 455
MET A 395
THR A 502
ILE A 503
 None
 1.21A 4p6xI-2x0qA:
undetectable		 4p6xI-2x0qA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw2 2-NITROPROPANE
DIOXYGENASE

(Streptomyces
ansochromogenes) 		PF03060
(NMO) 		5 LEU A 149
GLN A 235
LEU A  37
ILE A 138
PHE A 128
 None
FMN  A 370 (-4.0A)
None
None
None
 1.40A 4p6xI-3bw2A:
undetectable		 4p6xI-3bw2A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		5 LEU A 124
GLN A  87
LEU A  83
THR A 202
PHE A 120
 None
 1.45A 4p6xI-3c0kA:
undetectable		 4p6xI-3c0kA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3v ARACHIN ARAH3
ISOFORM

(Arachis
hypogaea) 		PF00190
(Cupin_1) 		5 LEU A 480
ASN A 479
GLY A 482
ILE A 477
PHE A 517
 None
 1.47A 4p6xI-3c3vA:
undetectable		 4p6xI-3c3vA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 417
LEU A 436
MET A 439
ILE A 218
PHE A 214
 None
 1.31A 4p6xI-3d5fA:
20.9		 4p6xI-3d5fA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A 230
ASN A 231
GLY A 270
MET A  65
PHE A 238
 None
 1.32A 4p6xI-3dkhA:
undetectable		 4p6xI-3dkhA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3

(Homo sapiens) 		PF00782
(DSPc) 		5 LEU A 177
ARG A 176
GLN A 143
THR A  34
ILE A  37
 None
 1.44A 4p6xI-3f81A:
undetectable		 4p6xI-3f81A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 GLY A 891
LEU A 869
MET A 952
THR A1068
ILE A1075
 None
 1.45A 4p6xI-3fawA:
undetectable		 4p6xI-3fawA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		5 LEU A 271
GLY A 145
GLN A 131
LEU A 135
ILE A 302
 None
 1.37A 4p6xI-3glbA:
undetectable		 4p6xI-3glbA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glg DNA POLYMERASE III
SUBUNIT DELTA

(Escherichia
coli) 		PF06144
(DNA_pol3_delta)
PF14840
(DNA_pol3_delt_C) 		5 LEU A  13
ASN A  14
GLY A  16
LEU A 109
GLN A  40
 None
 0.86A 4p6xI-3glgA:
undetectable		 4p6xI-3glgA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLY A 540
GLN A 543
GLN A 640
THR A 566
ILE A 793
 None
 1.29A 4p6xI-3ho8A:
undetectable		 4p6xI-3ho8A:
11.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLY A 722
GLN A 725
MET A 756
LEU A 763
ARG A 766
MET A 801
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
 0.90A 4p6xI-3kbaA:
34.7		 4p6xI-3kbaA:
54.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 718
ASN A 719
GLY A 722
MET A 756
LEU A 763
ARG A 766
MET A 801
THR A 894
PHE A 905
 WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.81A 4p6xI-3kbaA:
34.7		 4p6xI-3kbaA:
54.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 LEU A 417
GLY A 420
LEU A 450
MET A 261
THR A 274
 None
 1.36A 4p6xI-3kjrA:
undetectable		 4p6xI-3kjrA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksx NITRATE TRANSPORT
PROTEIN

(Xanthomonas
citri) 		PF09084
(NMT1) 		5 LEU A  50
GLN A 237
LEU A 241
ARG A 244
ILE A  60
 None
 1.41A 4p6xI-3ksxA:
undetectable		 4p6xI-3ksxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME

([Candida]
glabrata) 		PF02110
(HK)
PF02581
(TMP-TENI) 		5 LEU A 485
ASN A 484
GLY A 240
ARG A 335
THR A 248
 None
 1.44A 4p6xI-3nm1A:
undetectable		 4p6xI-3nm1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME

([Candida]
glabrata) 		PF02110
(HK)
PF02581
(TMP-TENI) 		5 LEU A 485
ASN A 484
GLY A 483
ARG A 335
THR A 248
 None
 1.26A 4p6xI-3nm1A:
undetectable		 4p6xI-3nm1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 152
LEU A 177
THR A 116
ILE A 118
PHE A 236
 None
 1.32A 4p6xI-3oc4A:
undetectable		 4p6xI-3oc4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		5 LEU A 166
GLY A 169
LEU A 139
THR A 179
PHE A 292
 None
FAD  A 401 (-3.6A)
FAD  A 401 (-4.7A)
None
None
 1.47A 4p6xI-3p9uA:
undetectable		 4p6xI-3p9uA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		5 LEU A 434
GLY A 276
LEU A 346
MET A 348
ILE A 417
 None
 1.31A 4p6xI-3pdiA:
undetectable		 4p6xI-3pdiA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnb OXACILLINASE

(Escherichia
coli) 		PF00905
(Transpeptidase) 		5 GLY A 110
GLN A 113
LEU A 192
ILE A 123
PHE A  90
 None
 1.19A 4p6xI-3qnbA:
undetectable		 4p6xI-3qnbA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qre ENOYL-COA HYDRATASE,
ECHA12_1

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 LEU A 173
GLY A 177
THR A 126
ILE A 157
PHE A 146
 None
 1.17A 4p6xI-3qreA:
undetectable		 4p6xI-3qreA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz1 STEROID
21-HYDROXYLASE

(Bos taurus) 		PF00067
(p450) 		5 LEU A 176
GLY A 179
MET A 259
ILE A 289
PHE A 189
 None
 1.25A 4p6xI-3qz1A:
2.3		 4p6xI-3qz1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rao PUTATIVE
LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		5 LEU A 249
GLY A 299
GLN A 303
GLN A 280
THR A 256
 None
None
SO4  A 354 (-4.6A)
None
None
 1.24A 4p6xI-3raoA:
undetectable		 4p6xI-3raoA:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		6 ASN A  33
GLY A  37
GLN A  39
MET A  70
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.15A 4p6xI-3ry9A:
36.1		 4p6xI-3ry9A:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		10 LEU A  32
ASN A  33
GLY A  36
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 115
THR A 208
PHE A 219
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.76A 4p6xI-3ry9A:
36.1		 4p6xI-3ry9A:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00701
(DHDPS) 		5 LEU A 220
LEU A 107
MET A 134
ILE A 205
PHE A 226
 None
 1.41A 4p6xI-3s5nA:
undetectable		 4p6xI-3s5nA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 LEU A 514
GLY A 517
LEU A 547
MET A 358
THR A 371
 None
UMP  A 611 (-3.3A)
None
None
None
 1.31A 4p6xI-3um6A:
undetectable		 4p6xI-3um6A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgf MALTO-OLIGOSYLTREHAL
OSE TREHALOHYDROLASE

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF09071
(Alpha-amyl_C) 		5 GLY A 116
LEU A 465
MET A 415
ILE A 141
PHE A 118
 GOL  A1101 (-3.7A)
None
None
None
None
 1.29A 4p6xI-3vgfA:
undetectable		 4p6xI-3vgfA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwy D-LACTATE
DEHYDROGENASE

(Fusobacterium
nucleatum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 206
ASN A 207
GLY A 236
LEU A 260
ILE A 151
 None
 0.77A 4p6xI-3wwyA:
undetectable		 4p6xI-3wwyA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 LEU A 202
ASN A 206
GLY A 204
LEU A 507
MET A 509
 None
 1.04A 4p6xI-4am3A:
undetectable		 4p6xI-4am3A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		5 GLY B 293
LEU B 246
ARG A 317
GLN B 228
THR A 413
 None
 1.32A 4p6xI-4cakB:
undetectable		 4p6xI-4cakB:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 LEU A  79
GLY A  82
GLN A  31
ILE A 137
PHE A 110
 None
 1.47A 4p6xI-4fn7A:
undetectable		 4p6xI-4fn7A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		5 GLY A 257
LEU A 297
MET A 300
ILE A 195
PHE A 252
 None
 1.42A 4p6xI-4i2wA:
undetectable		 4p6xI-4i2wA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY

(Danio rerio;
Escherichia
coli) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 LEU A  76
GLY A  70
ARG A 383
ILE A  61
PHE A  68
 None
 1.42A 4p6xI-4irlA:
undetectable		 4p6xI-4irlA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqk NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF02277
(DBI_PRT) 		5 LEU A 169
GLY A  59
LEU A  46
MET A  49
THR A 159
 None
 1.46A 4p6xI-4kqkA:
undetectable		 4p6xI-4kqkA:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 564
GLY A 567
LEU A 627
THR A 739
PHE A 749
 MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
None
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
 1.44A 4p6xI-4p6wA:
40.4		 4p6xI-4p6wA:
98.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 564
GLY A 568
GLN A 570
MET A 601
THR A 739
ILE A 747
PHE A 749
 MOF  A 801 (-3.0A)
None
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
 1.14A 4p6xI-4p6wA:
40.4		 4p6xI-4p6wA:
98.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 563
ASN A 564
GLY A 567
GLN A 570
MET A 601
LEU A 608
ARG A 611
MET A 646
THR A 739
ILE A 747
PHE A 749
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
 0.43A 4p6xI-4p6wA:
40.4		 4p6xI-4p6wA:
98.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 ASN A 196
GLY A 194
GLN A 193
LEU A 353
THR A 579
 None
None
None
IBP  A 601 ( 4.7A)
None
 1.45A 4p6xI-4ph9A:
undetectable		 4p6xI-4ph9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 LEU A 535
ASN A 538
GLY A 537
GLN A 209
ILE A 338
 EDO  A 616 ( 4.4A)
None
None
None
None
 1.11A 4p6xI-4ph9A:
undetectable		 4p6xI-4ph9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8d SORCIN

(Homo sapiens) 		PF13405
(EF-hand_6)
PF13833
(EF-hand_8) 		5 LEU A  58
GLY A  62
LEU A  35
ILE A 160
PHE A 156
 None
 1.27A 4p6xI-4u8dA:
undetectable		 4p6xI-4u8dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 LEU A 393
GLY A 395
THR A 408
ILE A 295
PHE A 400
 None
 0.76A 4p6xI-4ud8A:
undetectable		 4p6xI-4ud8A:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 770
GLY A 774
GLN A 776
THR A 945
PHE A 956
 CV7  A1987 (-3.1A)
None
CV7  A1987 (-3.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 1.34A 4p6xI-4udbA:
34.5		 4p6xI-4udbA:
54.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 769
ASN A 770
GLN A 776
MET A 807
LEU A 814
ARG A 817
MET A 852
THR A 945
PHE A 956
 CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 0.67A 4p6xI-4udbA:
34.5		 4p6xI-4udbA:
54.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmh HEME OXYGENASE 2

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		5 MET A 158
LEU A  97
MET A 206
THR A  41
PHE A 227
 None
 1.39A 4p6xI-4wmhA:
undetectable		 4p6xI-4wmhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zke SUPERKILLER PROTEIN
7

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU) 		5 LEU A 676
ASN A 683
LEU A 373
ILE A 710
PHE A 715
 LEU  A 676 ( 0.6A)
ASN  A 683 ( 0.6A)
LEU  A 373 ( 0.6A)
ILE  A 710 ( 0.7A)
PHE  A 715 ( 1.3A)
 1.47A 4p6xI-4zkeA:
undetectable		 4p6xI-4zkeA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az0 UNCHARACTERIZED
PROTEIN

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		5 MET A 248
LEU A 243
MET A 229
ILE A 290
PHE A 293
 None
 1.26A 4p6xI-5az0A:
undetectable		 4p6xI-5az0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E

(Homo sapiens) 		PF00777
(Glyco_transf_29) 		5 GLY A 302
LEU A 299
GLN A 100
THR A 372
ILE A 316
 CDP  A 411 (-3.3A)
None
None
None
None
 1.39A 4p6xI-5bo6A:
undetectable		 4p6xI-5bo6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 LEU A  23
GLY A  27
LEU A 326
THR A 123
ILE A 119
 None
 1.10A 4p6xI-5eowA:
undetectable		 4p6xI-5eowA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex6 CYTOCHROME P450

(Streptomyces
toyocaensis) 		no annotation 5 LEU C  88
ASN C  87
GLY C  86
ARG C  98
THR C 287
 HEM  C 502 (-3.7A)
None
None
None
HEM  C 502 (-3.5A)
 1.43A 4p6xI-5ex6C:
undetectable		 4p6xI-5ex6C:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g6r IMINE REDUCTASE

(Aspergillus
oryzae) 		PF03446
(NAD_binding_2) 		5 ASN A  93
GLY A  94
GLN A  98
LEU A 102
ILE A 118
 NDP  A1000 (-3.5A)
None
None
None
NDP  A1000 (-4.3A)
 1.45A 4p6xI-5g6rA:
undetectable		 4p6xI-5g6rA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		5 LEU A 130
GLY A 124
GLN A 127
ILE A 115
PHE A 122
 None
 1.43A 4p6xI-5hzwA:
undetectable		 4p6xI-5hzwA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 LEU A 534
ASN A 537
GLY A 536
GLN A 208
ILE A 337
 None
 1.10A 4p6xI-5ikrA:
undetectable		 4p6xI-5ikrA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kin TRYPTOPHAN SYNTHASE
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00291
(PALP) 		5 GLY B 244
GLN B 209
GLN B 219
ILE B 377
PHE B 249
 None
LLP  B  91 ( 4.6A)
None
None
None
 1.33A 4p6xI-5kinB:
undetectable		 4p6xI-5kinB:
19.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 ASN A 770
GLY A 774
GLN A 776
THR A 945
PHE A 956
 ECV  A1101 (-3.1A)
None
ECV  A1101 (-2.9A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 1.29A 4p6xI-5mwpA:
34.9		 4p6xI-5mwpA:
45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 GLN A 776
MET A 807
LEU A 814
ARG A 817
MET A 852
 ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
 1.31A 4p6xI-5mwpA:
34.9		 4p6xI-5mwpA:
45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 8 LEU A 769
ASN A 770
GLN A 776
MET A 807
LEU A 814
ARG A 817
THR A 945
PHE A 956
 ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 0.57A 4p6xI-5mwpA:
34.9		 4p6xI-5mwpA:
45.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6c D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Homo sapiens) 		no annotation 5 LEU A 217
ASN A 218
GLY A 215
LEU A 151
GLN A 224
 None
 1.43A 4p6xI-5n6cA:
undetectable		 4p6xI-5n6cA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzp D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Homo sapiens) 		no annotation 5 LEU B 217
ASN B 218
GLY B 215
LEU B 151
GLN B 224
 None
None
None
9EW  B 301 ( 4.8A)
None
 1.30A 4p6xI-5nzpB:
undetectable		 4p6xI-5nzpB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojl IMINE REDUCTASE

(Aspergillus
terreus) 		no annotation 5 ASN A  98
GLY A  99
GLN A 103
LEU A 107
ILE A 123
 TXP  A 302 (-3.3A)
None
None
None
TXP  A 302 (-4.3A)
 1.48A 4p6xI-5ojlA:
undetectable		 4p6xI-5ojlA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		5 LEU T2973
GLY T2939
GLN T2924
GLN T2910
ILE T2943
 None
 1.26A 4p6xI-5ojsT:
undetectable		 4p6xI-5ojsT:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tov ADENOSYLHOMOCYSTEINA
SE

(Thermotoga
maritima) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A 279
GLY A 325
LEU A 294
THR A 190
ILE A 186
 None
 1.44A 4p6xI-5tovA:
undetectable		 4p6xI-5tovA:
23.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 7 LEU A 559
ASN A 560
GLY A 563
GLN A 566
LEU A 604
ARG A 607
GLN A 638
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
486  A 801 (-4.6A)
 0.86A 4p6xI-5uc1A:
26.8		 4p6xI-5uc1A:
96.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 8 LEU A 559
ASN A 560
GLY A 563
GLN A 566
MET A 597
LEU A 604
ARG A 607
MET A 642
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
486  A 801 ( 3.8A)
 0.83A 4p6xI-5uc1A:
26.8		 4p6xI-5uc1A:
96.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  36
LEU A  96
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
None
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 1.44A 4p6xI-5ufsA:
38.7		 4p6xI-5ufsA:
76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 ASN A  33
GLY A  37
GLN A  39
MET A  70
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
None
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 1.12A 4p6xI-5ufsA:
38.7		 4p6xI-5ufsA:
76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 GLN A  39
MET A  70
LEU A  77
ARG A  80
GLN A 111
MET A 115
 1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
None
1TA  A 301 ( 2.8A)
 1.17A 4p6xI-5ufsA:
38.7		 4p6xI-5ufsA:
76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		10 LEU A  32
ASN A  33
GLY A  36
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 115
THR A 208
PHE A 218
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 0.45A 4p6xI-5ufsA:
38.7		 4p6xI-5ufsA:
76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 268
GLY A 266
LEU A 431
ILE A 302
PHE A 292
 None
 1.27A 4p6xI-5yk2A:
undetectable		 4p6xI-5yk2A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6an0 HISTIDINOL
DEHYDROGENASE

(Elizabethkingia
anophelis) 		PF00815
(Histidinol_dh) 		5 LEU A 173
ASN A 172
GLY A 175
LEU A 137
ILE A  71
 None
 1.37A 4p6xI-6an0A:
undetectable		 4p6xI-6an0A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aom ENDOPLASMIN

(Canis lupus) 		no annotation 5 GLY A 193
LEU A  93
THR A 171
ILE A 166
PHE A 195
 None
 1.39A 4p6xI-6aomA:
undetectable		 4p6xI-6aomA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au8 GOLGI TO ER TRAFFIC
PROTEIN 4 HOMOLOG
LARGE PROLINE-RICH
PROTEIN BAG6

(Homo sapiens) 		no annotation 5 GLN C1023
LEU A 266
THR A 220
ILE A 226
PHE A 232
 None
 1.46A 4p6xI-6au8C:
undetectable		 4p6xI-6au8C:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e85 -

(-) 		no annotation 5 GLY A 288
ARG A 182
THR A 107
ILE A 118
PHE A 291
 None
 1.13A 4p6xI-6e85A:
undetectable		 4p6xI-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsh OXYB PROTEIN

(Actinoplanes
teichomyceticus) 		no annotation 5 LEU A  88
ASN A  87
GLY A  86
ARG A  98
THR A 287
 HEM  A 401 (-3.3A)
None
None
None
HEM  A 401 (-3.8A)
 1.36A 4p6xI-6fshA:
undetectable		 4p6xI-6fshA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a59 CITRATE SYNTHASE

(Antarctic
bacterium
DS2-3R) 		PF00285
(Citrate_synt) 		3 MET A 124
MET A 180
TYR A  50
 None
 0.93A 4p6xI-1a59A:
0.0		 4p6xI-1a59A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amo NADPH-CYTOCHROME
P450 REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 MET A 301
MET A 541
TYR A 456
 None
None
FAD  A 750 (-4.3A)
 1.34A 4p6xI-1amoA:
0.0		 4p6xI-1amoA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)

(Hordeum vulgare) 		PF01373
(Glyco_hydro_14) 		3 MET A 439
MET A 494
TYR A 389
 None
 1.11A 4p6xI-1b1yA:
0.0		 4p6xI-1b1yA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)

(Trypanosoma
cruzi) 		PF00155
(Aminotran_1_2) 		3 MET A 222
MET A 323
TYR A 345
 LLP  A 253 ( 3.7A)
None
None
 1.34A 4p6xI-1bw0A:
0.0		 4p6xI-1bw0A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cn3 COAT PROTEIN VP1

(Polyomavirus
sp.) 		PF00718
(Polyoma_coat) 		3 MET A 100
MET A  57
TYR A 222
 None
 1.24A 4p6xI-1cn3A:
0.0		 4p6xI-1cn3A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		3 MET A 431
MET A 440
TYR A 375
 None
 1.17A 4p6xI-1dgjA:
0.0		 4p6xI-1dgjA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 MET A 477
MET A 481
TYR A 327
 None
 1.21A 4p6xI-1dlcA:
1.2		 4p6xI-1dlcA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e7s GDP-FUCOSE
SYNTHETASE

(Escherichia
coli) 		PF01370
(Epimerase) 		3 MET A  14
MET A 162
TYR A 167
 NAP  A1317 (-3.0A)
None
None
 1.19A 4p6xI-1e7sA:
0.0		 4p6xI-1e7sA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ilo CONSERVED
HYPOTHETICAL PROTEIN
MTH895

(Methanothermobacter
thermautotrophicus) 		PF13192
(Thioredoxin_3) 		3 MET A  63
MET A  16
TYR A   7
 None
 1.27A 4p6xI-1iloA:
0.0		 4p6xI-1iloA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		3 MET A 275
MET A 158
TYR A 260
 None
 1.24A 4p6xI-1l1lA:
undetectable		 4p6xI-1l1lA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		3 MET A 180
MET A 166
TYR A 160
 2FA  A 306 (-3.8A)
None
None
 0.73A 4p6xI-1pk9A:
undetectable		 4p6xI-1pk9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ty4 APOPTOSIS REGULATOR
CED-9
EGG LAYING DEFECTIVE
EGL-1, PROGRAMMED
CELL DEATH ACTIVATOR

(Caenorhabditis
elegans) 		PF00452
(Bcl-2)
PF02180
(BH4)
PF11430
(EGL-1) 		3 MET A 119
MET C  61
TYR A 168
 None
 1.23A 4p6xI-1ty4A:
undetectable		 4p6xI-1ty4A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzz PROBABLE
ENDOGLUCANASE

(Komagataeibacter
xylinus) 		PF01270
(Glyco_hydro_8) 		3 MET A 150
MET A 201
TYR A 179
 None
 1.33A 4p6xI-1wzzA:
undetectable		 4p6xI-1wzzA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2o HYPOTHETICAL PROTEIN
BT3146

(Bacteroides
thetaiotaomicron) 		no annotation 3 MET A 226
MET A 157
TYR A 166
 None
 0.85A 4p6xI-2a2oA:
undetectable		 4p6xI-2a2oA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14

(Homo sapiens) 		PF00443
(UCH) 		3 MET A 180
MET A 206
TYR A 150
 None
 1.26A 4p6xI-2aynA:
undetectable		 4p6xI-2aynA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b44 GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM

(Staphylococcus
aureus) 		PF01551
(Peptidase_M23) 		3 MET A 217
MET A 259
TYR A 224
 None
 1.27A 4p6xI-2b44A:
undetectable		 4p6xI-2b44A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dao TRANSCRIPTION FACTOR
ETV6

(Homo sapiens) 		PF00178
(Ets) 		3 MET A  97
MET A  90
TYR A  16
 None
 1.32A 4p6xI-2daoA:
undetectable		 4p6xI-2daoA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		3 MET A 165
MET A 183
TYR A 158
 None
 0.98A 4p6xI-2dw6A:
undetectable		 4p6xI-2dw6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 MET A 298
MET A 307
TYR A  96
 None
 1.21A 4p6xI-2eklA:
undetectable		 4p6xI-2eklA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE

(Enterococcus
faecalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		3 MET A   1
MET A  94
TYR A 100
 None
 1.04A 4p6xI-2ew2A:
undetectable		 4p6xI-2ew2A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 MET A1024
MET A 984
TYR A 992
 None
 1.42A 4p6xI-2gjtA:
undetectable		 4p6xI-2gjtA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qor GUANYLATE KINASE

(Plasmodium
vivax) 		PF00625
(Guanylate_kin) 		3 MET A 102
MET A 158
TYR A 121
 None
 1.19A 4p6xI-2qorA:
undetectable		 4p6xI-2qorA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs8 XAA-PRO DIPEPTIDASE

(Alteromonas
macleodii) 		PF01979
(Amidohydro_1) 		3 MET A  68
MET A 230
TYR A 273
 None
 1.42A 4p6xI-2qs8A:
undetectable		 4p6xI-2qs8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv5 UNCHARACTERIZED
PROTEIN ATU2773

(Agrobacterium
fabrum) 		PF04748
(Polysacc_deac_2) 		3 MET A 217
MET A 275
TYR A 165
 None
 1.12A 4p6xI-2qv5A:
undetectable		 4p6xI-2qv5A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		3 MET A 477
MET A 536
TYR A 449
 None
 1.18A 4p6xI-2qzpA:
undetectable		 4p6xI-2qzpA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r09 CYTOHESIN-3

(Mus musculus) 		PF00169
(PH)
PF01369
(Sec7) 		3 MET A 199
MET A 169
TYR A 385
 PE5  A 407 ( 3.9A)
None
PE5  A 407 (-3.7A)
 1.17A 4p6xI-2r09A:
undetectable		 4p6xI-2r09A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		3 MET G 658
MET G1011
TYR G 624
 None
 1.20A 4p6xI-2uv8G:
undetectable		 4p6xI-2uv8G:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w31 GLOBIN

(Geobacter
sulfurreducens) 		PF11563
(Protoglobin) 		3 MET A 146
MET A   1
TYR A  82
 HEM  A 200 ( 3.7A)
None
None
 1.38A 4p6xI-2w31A:
2.5		 4p6xI-2w31A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		3 MET A 112
MET A  82
TYR A 165
 None
 1.41A 4p6xI-2ww2A:
undetectable		 4p6xI-2ww2A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1o GELSOLIN NANOBODY

(Lama glama) 		PF07686
(V-set) 		3 MET A  34
MET A 106
TYR A 111
 None
 1.22A 4p6xI-2x1oA:
undetectable		 4p6xI-2x1oA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 3 MET A 328
MET A 621
TYR A 264
 None
 1.32A 4p6xI-2yr5A:
undetectable		 4p6xI-2yr5A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		3 MET A 374
MET A 411
TYR A 418
 None
 1.39A 4p6xI-3a5iA:
undetectable		 4p6xI-3a5iA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl3 ORF K13

(Human
gammaherpesvirus
8) 		PF01335
(DED) 		3 MET A 171
MET A  88
TYR A  94
 None
 1.24A 4p6xI-3cl3A:
undetectable		 4p6xI-3cl3A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh1 TRNA-SPECIFIC
ADENOSINE DEAMINASE
2

(Homo sapiens) 		PF14437
(MafB19-deam) 		3 MET A  30
MET A  48
TYR A 158
 None
 1.39A 4p6xI-3dh1A:
undetectable		 4p6xI-3dh1A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hqi SPECKLE-TYPE POZ
PROTEIN

(Homo sapiens) 		PF00651
(BTB)
PF00917
(MATH) 		3 MET A 255
MET A 288
TYR A 280
 None
 1.19A 4p6xI-3hqiA:
undetectable		 4p6xI-3hqiA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htm SPECKLE-TYPE POZ
PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		3 MET A 255
MET A 288
TYR A 280
 None
 1.25A 4p6xI-3htmA:
undetectable		 4p6xI-3htmA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4t DIPHTHINE SYNTHASE

(Entamoeba
histolytica) 		PF00590
(TP_methylase) 		3 MET A 214
MET A 218
TYR A 268
 None
 1.11A 4p6xI-3i4tA:
undetectable		 4p6xI-3i4tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibh SACCHAROMYCES
CEREVISIAE GTT2

(Saccharomyces
cerevisiae) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		3 MET A 163
MET A 116
TYR A 213
 None
 1.28A 4p6xI-3ibhA:
undetectable		 4p6xI-3ibhA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 3 MET A  87
MET A 122
TYR A 187
 None
 1.25A 4p6xI-3j4uA:
undetectable		 4p6xI-3j4uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		3 MET A 296
MET A 300
TYR A 283
 None
 1.37A 4p6xI-3koyA:
undetectable		 4p6xI-3koyA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7

(Homo sapiens) 		PF00620
(RhoGAP) 		3 MET A1099
MET A1128
TYR A1153
 None
 1.17A 4p6xI-3kuqA:
undetectable		 4p6xI-3kuqA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		3 MET A   1
MET A 220
TYR A 128
 None
 1.42A 4p6xI-3mmtA:
undetectable		 4p6xI-3mmtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a DIHEME CYTOCHROME C
NAPB
PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF03892
(NapB)
PF04879
(Molybdop_Fe4S4) 		3 MET B   6
MET A 458
TYR A 485
 None
 1.16A 4p6xI-3o5aB:
undetectable		 4p6xI-3o5aB:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odh OKRAI ENDONUCLEASE

(Oceanobacter
kriegii) 		PF02923
(BamHI) 		3 MET A 119
MET A  90
TYR A 166
 None
 1.20A 4p6xI-3odhA:
undetectable		 4p6xI-3odhA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnd THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE

(Salmonella
enterica) 		PF02424
(ApbE) 		3 MET A  41
MET A  85
TYR A 189
 FAD  A 500 (-3.7A)
None
SO4  A 360 (-4.8A)
 0.92A 4p6xI-3pndA:
undetectable		 4p6xI-3pndA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q7z BETA-LACTAMASE
REGULATORY PROTEIN
BLAR1

(Staphylococcus
aureus) 		PF00905
(Transpeptidase) 		3 MET A 368
MET A 579
TYR A 544
 None
 1.30A 4p6xI-3q7zA:
undetectable		 4p6xI-3q7zA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh9 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(NAD(P)(+))

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		3 MET A   1
MET A 321
TYR A  30
 None
 1.22A 4p6xI-3rh9A:
undetectable		 4p6xI-3rh9A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 3 MET N 376
MET N 388
TYR N 425
 None
 0.90A 4p6xI-3rkoN:
undetectable		 4p6xI-3rkoN:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 MET A 515
MET A 445
TYR A 456
 None
 1.29A 4p6xI-3sghA:
undetectable		 4p6xI-3sghA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shs HOC HEAD OUTER
CAPSID PROTEIN

(Escherichia
virus RB49) 		no annotation 3 MET A 184
MET A 180
TYR A 280
 None
 1.15A 4p6xI-3shsA:
undetectable		 4p6xI-3shsA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB

(Methanosarcina
barkeri) 		PF04055
(Radical_SAM) 		3 MET A 150
MET A 144
TYR A 121
 None
MD0  A 993 ( 4.5A)
None
 1.25A 4p6xI-3t7vA:
undetectable		 4p6xI-3t7vA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb5 METHIONINE
AMINOPEPTIDASE

(Enterococcus
faecalis) 		PF00557
(Peptidase_M24) 		3 MET A  95
MET A 203
TYR A 110
 None
 1.39A 4p6xI-3tb5A:
undetectable		 4p6xI-3tb5A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0j TYPE III EFFECTOR
HOPU1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 3 MET B 144
MET B 153
TYR B  82
 None
 1.16A 4p6xI-3u0jB:
undetectable		 4p6xI-3u0jB:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u80 3-DEHYDROQUINATE
DEHYDRATASE, TYPE II

(Bifidobacterium
longum) 		PF01220
(DHquinase_II) 		3 MET A  57
MET A  91
TYR A  81
 None
 1.39A 4p6xI-3u80A:
undetectable		 4p6xI-3u80A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		3 MET A 794
MET A 741
TYR A 392
 None
 1.07A 4p6xI-3ummA:
undetectable		 4p6xI-3ummA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		3 MET D 194
MET D 316
TYR D 263
 None
 1.33A 4p6xI-3w3aD:
undetectable		 4p6xI-3w3aD:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acv PROPHAGE LAMBDALM01,
ANTIGEN B

(Listeria
monocytogenes) 		PF16807
(DUF5072) 		3 MET B  42
MET B  16
TYR B  58
 None
 1.37A 4p6xI-4acvB:
undetectable		 4p6xI-4acvB:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN

(Pyrococcus sp.
ST04) 		no annotation 3 MET A 476
MET A 442
TYR A 494
 None
 1.07A 4p6xI-4cmrA:
undetectable		 4p6xI-4cmrA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eoz SPECKLE-TYPE POZ
PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		3 MET A 255
MET A 288
TYR A 280
 None
 1.23A 4p6xI-4eozA:
undetectable		 4p6xI-4eozA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		3 MET A1246
MET A1198
TYR A1236
 None
 1.33A 4p6xI-4f0gA:
undetectable		 4p6xI-4f0gA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 MET A1015
MET A1000
TYR A1022
 None
 1.29A 4p6xI-4f4cA:
undetectable		 4p6xI-4f4cA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk8 HISTIDINOL-PHOSPHATA
SE

(Lactococcus
lactis) 		PF02811
(PHP) 		3 MET A  50
MET A  82
TYR A 117
 GK8  A 305 ( 3.9A)
None
GK8  A 305 ( 3.9A)
 1.44A 4p6xI-4gk8A:
undetectable		 4p6xI-4gk8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl3 PUTATIVE
GLUCOAMYLASE

(Bacteroides
uniformis) 		PF10091
(Glycoamylase) 		3 MET A 412
MET A 155
TYR A 281
 None
 1.32A 4p6xI-4gl3A:
undetectable		 4p6xI-4gl3A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8z SPECKLE-TYPE POZ
PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		3 MET A 255
MET A 288
TYR A 280
 None
 1.27A 4p6xI-4j8zA:
undetectable		 4p6xI-4j8zA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4km3 METHIONINE
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF00557
(Peptidase_M24) 		3 MET A  99
MET A 234
TYR A 141
 None
 1.30A 4p6xI-4km3A:
undetectable		 4p6xI-4km3A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npb PROTEIN DISULFIDE
ISOMERASE II

(Yersinia pestis) 		PF10411
(DsbC_N)
PF13098
(Thioredoxin_2) 		3 MET A 174
MET A 163
TYR A 141
 None
 1.37A 4p6xI-4npbA:
undetectable		 4p6xI-4npbA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pot VP1

(Human
polyomavirus 9) 		PF00718
(Polyoma_coat) 		3 MET A 123
MET A  56
TYR A  51
 None
 0.99A 4p6xI-4potA:
undetectable		 4p6xI-4potA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhm ARGINASE

(Trypanosoma
brucei) 		PF00491
(Arginase) 		3 MET A  35
MET A  84
TYR A 269
 None
 1.35A 4p6xI-4rhmA:
undetectable		 4p6xI-4rhmA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax) 		PF01979
(Amidohydro_1) 		3 MET A 173
MET A 155
TYR A  83
 None
 1.14A 4p6xI-4wgxA:
undetectable		 4p6xI-4wgxA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnx NETRIN-4

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		3 MET A  38
MET A 294
TYR A 126
 None
 1.01A 4p6xI-4wnxA:
undetectable		 4p6xI-4wnxA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 MET A 661
MET A 935
TYR A 644
 None
 1.17A 4p6xI-4wz9A:
undetectable		 4p6xI-4wz9A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0r INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX2

(Homo sapiens) 		no annotation 3 MET B 155
MET B 112
TYR B 212
 None
 1.34A 4p6xI-4x0rB:
undetectable		 4p6xI-4x0rB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x7m TARM

(Staphylococcus
aureus) 		PF00534
(Glycos_transf_1) 		3 MET A 327
MET A 409
TYR A 355
 None
 1.21A 4p6xI-4x7mA:
undetectable		 4p6xI-4x7mA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb3 GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Streptococcus
mutans) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 MET A 356
MET A 395
TYR A 349
 None
 1.28A 4p6xI-4xb3A:
undetectable		 4p6xI-4xb3A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		3 MET A 350
MET A 342
TYR A 364
 None
 1.40A 4p6xI-4xhjA:
undetectable		 4p6xI-4xhjA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyb FORMATE
DEHYDROGENASE

(Granulicella
mallensis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 MET A 193
MET A 245
TYR A 279
 None
 1.43A 4p6xI-4xybA:
undetectable		 4p6xI-4xybA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7c S-CRYSTALLIN OCTVUS4

(Octopus
vulgaris) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 MET A 162
MET A 143
TYR A 170
 None
 1.18A 4p6xI-5b7cA:
undetectable		 4p6xI-5b7cA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8s GUANINE-N7
METHYLTRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		3 MET B 315
MET B 500
TYR B 491
 None
 1.23A 4p6xI-5c8sB:
undetectable		 4p6xI-5c8sB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1p ATP-DEPENDENT RNA
LIGASE

(Methanothermobacter
thermautotrophicus) 		PF09414
(RNA_ligase) 		3 MET A 235
MET A  98
TYR A 247
 None
APK  A  97 ( 4.2A)
None
 1.24A 4p6xI-5d1pA:
undetectable		 4p6xI-5d1pA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 MET A 484
MET A 365
TYR A 227
 None
 1.25A 4p6xI-5g2vA:
undetectable		 4p6xI-5g2vA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjn LYSINE/ORNITHINE
DECARBOXYLASE

(Selenomonas
ruminantium) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 MET A  90
MET A 124
TYR A 108
 None
 1.44A 4p6xI-5gjnA:
undetectable		 4p6xI-5gjnA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		3 MET F 796
MET F 864
TYR F 782
 None
 1.42A 4p6xI-5gjwF:
undetectable		 4p6xI-5gjwF:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp4 GLUTAMATE
DECARBOXYLASE

(Lactobacillus
brevis) 		no annotation 3 MET C 185
MET C 212
TYR C 216
 None
 1.43A 4p6xI-5gp4C:
undetectable		 4p6xI-5gp4C:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzh ENDO-BETA-1,2-GLUCAN
ASE

(Chitinophaga
pinensis) 		PF10091
(Glycoamylase) 		3 MET A 407
MET A 146
TYR A 274
 None
 1.29A 4p6xI-5gzhA:
undetectable		 4p6xI-5gzhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ica PERIODIC TRYPTOPHAN
PROTEIN 2-LIKE
PROTEIN
PUTATIVE U3 SNORNP
PROTEIN

(Chaetomium
thermophilum) 		PF04003
(Utp12)
PF04192
(Utp21) 		3 MET C1007
MET C 995
TYR D 843
 None
 1.20A 4p6xI-5icaC:
undetectable		 4p6xI-5icaC:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL

(Coccidioides
posadasii) 		PF00579
(tRNA-synt_1b) 		3 MET A 295
MET A 239
TYR A 288
 None
 0.91A 4p6xI-5ijxA:
undetectable		 4p6xI-5ijxA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2m RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN

(Thermococcus
kodakarensis) 		PF08443
(RimK) 		3 MET A  15
MET A 246
TYR A   7
 None
 1.27A 4p6xI-5k2mA:
undetectable		 4p6xI-5k2mA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kov CAPSID POLYPROTEIN
VP90

(Mamastrovirus 1) 		PF12226
(Astro_capsid_p) 		3 MET A 480
MET A 508
TYR A 590
 None
 0.77A 4p6xI-5kovA:
undetectable		 4p6xI-5kovA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		3 MET A 388
MET A 472
TYR A 144
 None
 1.36A 4p6xI-5ktkA:
undetectable		 4p6xI-5ktkA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL

(Bos taurus) 		PF00346
(Complex1_49kDa) 		3 MET D 152
MET D 112
TYR D 108
 None
 1.39A 4p6xI-5lc5D:
undetectable		 4p6xI-5lc5D:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 MET A 287
MET A 360
TYR A 370
 None
 1.21A 4p6xI-5vniA:
undetectable		 4p6xI-5vniA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wez TIR CHAPERONE

(Escherichia
coli) 		no annotation 3 MET A  50
MET A 120
TYR A  83
 None
 1.10A 4p6xI-5wezA:
undetectable		 4p6xI-5wezA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z95 -

(-) 		no annotation 3 MET A 219
MET A  99
TYR A  26
 EGC  A 301 (-3.8A)
None
EGC  A 301 ( 4.7A)
 1.40A 4p6xI-5z95A:
undetectable		 4p6xI-5z95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 3 MET A 166
MET A 113
TYR A 189
 None
 1.23A 4p6xI-6byxA:
undetectable		 4p6xI-6byxA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 3 MET A1018
MET A1022
TYR A1057
 None
 1.40A 4p6xI-6eojA:
undetectable		 4p6xI-6eojA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eot DIPEPTIDYL PEPTIDASE
8

(Homo sapiens) 		no annotation 3 MET A 722
MET A 813
TYR A 787
 None
 1.34A 4p6xI-6eotA:
undetectable		 4p6xI-6eotA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd PROTEASOME SUBUNIT
BETA TYPE-4
PROTEASOME SUBUNIT
BETA TYPE-6

(Rattus
norvegicus) 		no annotation 3 MET 1 153
MET 7  49
TYR 7 106
 None
 1.02A 4p6xI-6epd1:
undetectable		 4p6xI-6epd1:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 3 MET A 499
MET A 440
TYR A 488
 None
EDO  A 806 (-3.5A)
None
 1.15A 4p6xI-6f91A:
undetectable		 4p6xI-6f91A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkq NETRIN-1

(Homo sapiens) 		no annotation 3 MET A 210
MET A 159
TYR A 272
 SO4  A 510 ( 4.4A)
None
None
 1.39A 4p6xI-6fkqA:
undetectable		 4p6xI-6fkqA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 3 MET A  94
MET A  26
TYR A 107
 None
 1.16A 4p6xI-6fuyA:
undetectable		 4p6xI-6fuyA:
14.90