SIMILAR PATTERNS OF AMINO ACIDS FOR 4P6X_G_HCYG900_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi) 		PF00365
(PFK) 		5 ASN A 456
GLY A 457
GLN A 197
LEU A  73
ILE A  28
 None
 1.35A 4p6xG-1kzhA:
undetectable		 4p6xG-1kzhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 TRP A 324
LEU A 249
THR A 338
ILE A 150
PHE A 158
 None
 1.43A 4p6xG-1nxkA:
undetectable		 4p6xG-1nxkA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 ASN A 213
GLN A 188
THR A  35
ILE A 109
PHE A 192
 None
 1.15A 4p6xG-1rj6A:
undetectable		 4p6xG-1rj6A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		5 GLY B 234
GLN B 200
GLN B 210
ILE B 367
PHE B 239
 None
 1.22A 4p6xG-1wdwB:
undetectable		 4p6xG-1wdwB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zov MONOMERIC SARCOSINE
OXIDASE

(Bacillus sp.
NS-129) 		PF01266
(DAO) 		5 GLY A 263
LEU A 298
MET A 302
THR A  87
PHE A 259
 None
 1.43A 4p6xG-1zovA:
undetectable		 4p6xG-1zovA:
18.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
PHE A 891
 BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
None
 0.86A 4p6xG-2ax9A:
32.2		 4p6xG-2ax9A:
49.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLY A 708
GLN A 711
MET A 742
ARG A 752
MET A 787
 BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
 0.93A 4p6xG-2ax9A:
32.2		 4p6xG-2ax9A:
49.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 GLY A 103
LEU A 374
GLN A  81
THR A  84
PHE A 145
 None
None
PLP  A1202 (-4.5A)
None
None
 1.47A 4p6xG-2cb1A:
undetectable		 4p6xG-2cb1A:
22.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 ASN A  33
GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
MET A 115
THR A 208
 1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
None
1CA  A 247 ( 3.8A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 ( 3.7A)
1CA  A 247 (-3.4A)
 0.72A 4p6xG-2q3yA:
36.2		 4p6xG-2q3yA:
63.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 ASN A  33
GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
THR A 208
PHE A 219
 1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
None
1CA  A 247 ( 3.8A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 0.51A 4p6xG-2q3yA:
36.2		 4p6xG-2q3yA:
63.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  37
TRP A  69
THR A 208
PHE A 219
 1CA  A 247 (-2.9A)
None
None
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 1.01A 4p6xG-2q3yA:
36.2		 4p6xG-2q3yA:
63.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgz HEME OXYGENASE 2

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		5 MET A 158
LEU A  97
MET A 206
THR A  41
PHE A 227
 None
None
None
None
HEM  A 300 (-4.1A)
 1.46A 4p6xG-2rgzA:
undetectable		 4p6xG-2rgzA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE

(Paraburkholderia
xenovorans) 		PF12697
(Abhydrolase_6) 		5 GLY A  19
MET A  82
LEU A  88
ILE A  25
PHE A  23
 None
 1.33A 4p6xG-2ri6A:
undetectable		 4p6xG-2ri6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 MET A 467
LEU A 455
MET A 395
THR A 502
ILE A 503
 None
 1.19A 4p6xG-2x0qA:
undetectable		 4p6xG-2x0qA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3

(Homo sapiens) 		PF00782
(DSPc) 		5 LEU A 177
ARG A 176
GLN A 143
THR A  34
ILE A  37
 None
 1.49A 4p6xG-3f81A:
undetectable		 4p6xG-3f81A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 GLY A 891
LEU A 869
MET A 952
THR A1068
ILE A1075
 None
 1.43A 4p6xG-3fawA:
undetectable		 4p6xG-3fawA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Francisella
tularensis) 		PF02540
(NAD_synthase) 		5 ASN A  66
GLY A 195
GLN A 200
LEU A 113
GLN A  91
 AMP  A3001 ( 3.7A)
None
None
None
None
 1.29A 4p6xG-3fiuA:
undetectable		 4p6xG-3fiuA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLY A 540
GLN A 543
GLN A 640
THR A 566
ILE A 793
 None
 1.26A 4p6xG-3ho8A:
undetectable		 4p6xG-3ho8A:
11.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 719
GLY A 722
LEU A 782
THR A 894
PHE A 905
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
None
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 1.49A 4p6xG-3kbaA:
35.0		 4p6xG-3kbaA:
54.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 ASN A 719
GLY A 722
MET A 756
LEU A 763
ARG A 766
MET A 801
THR A 894
PHE A 905
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.81A 4p6xG-3kbaA:
35.0		 4p6xG-3kbaA:
54.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 719
TRP A 755
MET A 756
LEU A 763
MET A 801
THR A 894
PHE A 905
 WOW  A   1 (-3.3A)
None
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 1.16A 4p6xG-3kbaA:
35.0		 4p6xG-3kbaA:
54.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLY A 722
GLN A 725
MET A 756
LEU A 763
ARG A 766
MET A 801
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
 0.90A 4p6xG-3kbaA:
35.0		 4p6xG-3kbaA:
54.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		5 TRP A 686
LEU A 608
THR A 700
ILE A 510
PHE A 516
 None
 1.40A 4p6xG-3kn5A:
undetectable		 4p6xG-3kn5A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0o MONOMERIC SARCOSINE
OXIDASE

(Bacillus sp.
B-0618) 		PF01266
(DAO) 		5 GLY A 263
LEU A 298
MET A 302
THR A  87
PHE A 259
 None
 1.48A 4p6xG-3m0oA:
undetectable		 4p6xG-3m0oA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672

(Caulobacter
vibrioides) 		PF01979
(Amidohydro_1) 		5 GLY A 217
LEU A 275
THR A 301
ILE A 347
PHE A 219
 M3R  A 430 (-3.5A)
None
None
M3R  A 430 ( 4.9A)
M3R  A 430 (-4.3A)
 1.41A 4p6xG-3mtwA:
undetectable		 4p6xG-3mtwA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 152
LEU A 177
THR A 116
ILE A 118
PHE A 236
 None
 1.34A 4p6xG-3oc4A:
undetectable		 4p6xG-3oc4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnb OXACILLINASE

(Escherichia
coli) 		PF00905
(Transpeptidase) 		5 GLY A 110
GLN A 113
LEU A 192
ILE A 123
PHE A  90
 None
 1.17A 4p6xG-3qnbA:
undetectable		 4p6xG-3qnbA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE

(Ralstonia
pickettii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A  85
GLN A  88
LEU A 288
THR A  40
ILE A  78
 None
None
None
None
CL  A 405 (-4.4A)
 1.09A 4p6xG-3rr1A:
undetectable		 4p6xG-3rr1A:
20.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		9 ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
MET A 115
THR A 208
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.2A)
 0.72A 4p6xG-3ry9A:
36.0		 4p6xG-3ry9A:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		9 ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.42A 4p6xG-3ry9A:
36.0		 4p6xG-3ry9A:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  37
TRP A  69
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
None
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.98A 4p6xG-3ry9A:
36.0		 4p6xG-3ry9A:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgf MALTO-OLIGOSYLTREHAL
OSE TREHALOHYDROLASE

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF09071
(Alpha-amyl_C) 		5 GLY A 116
LEU A 465
MET A 415
ILE A 141
PHE A 118
 GOL  A1101 (-3.7A)
None
None
None
None
 1.31A 4p6xG-3vgfA:
undetectable		 4p6xG-3vgfA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		5 GLY A 475
LEU A 388
GLN A 355
THR A 351
ILE A 533
 None
 1.18A 4p6xG-4c22A:
undetectable		 4p6xG-4c22A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		5 GLY B 293
LEU B 246
ARG A 317
GLN B 228
THR A 413
 None
 1.34A 4p6xG-4cakB:
undetectable		 4p6xG-4cakB:
16.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ASN A 564
GLY A 567
GLN A 570
TRP A 600
MET A 601
LEU A 608
ARG A 611
MET A 646
THR A 739
ILE A 747
PHE A 749
 MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
 0.42A 4p6xG-4p6wA:
40.5		 4p6xG-4p6wA:
98.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 564
GLY A 567
LEU A 627
THR A 739
PHE A 749
 MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
None
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
 1.42A 4p6xG-4p6wA:
40.5		 4p6xG-4p6wA:
98.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 564
GLY A 568
TRP A 600
MET A 601
THR A 739
ILE A 747
PHE A 749
 MOF  A 801 (-3.0A)
None
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
 0.94A 4p6xG-4p6wA:
40.5		 4p6xG-4p6wA:
98.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 601
LEU A 608
ARG A 611
GLN A 642
MET A 646
 MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
None
MOF  A 801 (-4.4A)
 0.92A 4p6xG-4p6wA:
40.5		 4p6xG-4p6wA:
98.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 ASN A 196
GLY A 194
GLN A 193
LEU A 353
THR A 579
 None
None
None
IBP  A 601 ( 4.7A)
None
 1.48A 4p6xG-4ph9A:
undetectable		 4p6xG-4ph9A:
19.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 ASN A 770
GLN A 776
TRP A 806
MET A 807
LEU A 814
ARG A 817
MET A 852
THR A 945
 CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-3.1A)
 0.66A 4p6xG-4udbA:
34.7		 4p6xG-4udbA:
54.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 ASN A 770
GLN A 776
TRP A 806
MET A 807
LEU A 814
ARG A 817
THR A 945
PHE A 956
 CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 0.36A 4p6xG-4udbA:
34.7		 4p6xG-4udbA:
54.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 770
GLY A 774
TRP A 806
THR A 945
PHE A 956
 CV7  A1987 (-3.1A)
None
None
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 1.09A 4p6xG-4udbA:
34.7		 4p6xG-4udbA:
54.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az0 UNCHARACTERIZED
PROTEIN

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		5 MET A 248
LEU A 243
MET A 229
ILE A 290
PHE A 293
 None
 1.23A 4p6xG-5az0A:
undetectable		 4p6xG-5az0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E

(Homo sapiens) 		PF00777
(Glyco_transf_29) 		5 GLY A 302
LEU A 299
GLN A 100
THR A 372
ILE A 316
 CDP  A 411 (-3.3A)
None
None
None
None
 1.37A 4p6xG-5bo6A:
undetectable		 4p6xG-5bo6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g6r IMINE REDUCTASE

(Aspergillus
oryzae) 		PF03446
(NAD_binding_2) 		5 ASN A  93
GLY A  94
GLN A  98
LEU A 102
ILE A 118
 NDP  A1000 (-3.5A)
None
None
None
NDP  A1000 (-4.3A)
 1.48A 4p6xG-5g6rA:
undetectable		 4p6xG-5g6rA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m23 WD REPEAT-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40) 		5 GLY A 183
GLN A 140
LEU A 143
ILE A 197
PHE A 222
 None
 1.50A 4p6xG-5m23A:
undetectable		 4p6xG-5m23A:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 8 ASN A 770
GLN A 776
TRP A 806
MET A 807
LEU A 814
ARG A 817
THR A 945
PHE A 956
 ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 0.48A 4p6xG-5mwpA:
34.8		 4p6xG-5mwpA:
45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 ASN A 770
GLY A 774
TRP A 806
THR A 945
PHE A 956
 ECV  A1101 (-3.1A)
None
None
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 1.02A 4p6xG-5mwpA:
34.8		 4p6xG-5mwpA:
45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 6 GLN A 776
TRP A 806
MET A 807
LEU A 814
ARG A 817
MET A 852
 ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
 1.22A 4p6xG-5mwpA:
34.8		 4p6xG-5mwpA:
45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 ASN A 560
GLY A 563
GLN A 566
LEU A 604
ARG A 607
GLN A 638
 486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
486  A 801 (-4.6A)
 0.64A 4p6xG-5uc1A:
26.7		 4p6xG-5uc1A:
96.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 7 ASN A 560
GLY A 563
GLN A 566
MET A 597
LEU A 604
ARG A 607
MET A 642
 486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
486  A 801 ( 3.8A)
 0.73A 4p6xG-5uc1A:
26.7		 4p6xG-5uc1A:
96.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 7 GLY A 563
GLN A 566
TRP A 596
MET A 597
LEU A 604
ARG A 607
MET A 642
 486  A 801 (-3.7A)
486  A 801 (-2.8A)
None
CPS  A 803 ( 3.9A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
486  A 801 ( 3.8A)
 0.75A 4p6xG-5uc1A:
26.7		 4p6xG-5uc1A:
96.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		10 ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
MET A 115
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
None
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 0.44A 4p6xG-5ufsA:
38.8		 4p6xG-5ufsA:
76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  36
LEU A  96
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
None
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 1.42A 4p6xG-5ufsA:
38.8		 4p6xG-5ufsA:
76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 ASN A  33
GLY A  37
TRP A  69
MET A  70
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
None
None
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 0.89A 4p6xG-5ufsA:
38.8		 4p6xG-5ufsA:
76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
GLN A 111
MET A 115
 1TA  A 301 (-3.0A)
None
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
None
1TA  A 301 ( 2.8A)
 1.05A 4p6xG-5ufsA:
38.8		 4p6xG-5ufsA:
76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C

(Homo sapiens) 		no annotation 5 ASN C 479
GLY C 482
LEU C 546
ARG C 549
MET C 525
 None
 1.47A 4p6xG-5yh3C:
undetectable		 4p6xG-5yh3C:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aom ENDOPLASMIN

(Canis lupus) 		no annotation 5 GLY A 193
LEU A  93
THR A 171
ILE A 166
PHE A 195
 None
 1.38A 4p6xG-6aomA:
undetectable		 4p6xG-6aomA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au8 GOLGI TO ER TRAFFIC
PROTEIN 4 HOMOLOG
LARGE PROLINE-RICH
PROTEIN BAG6

(Homo sapiens) 		no annotation 5 GLN C1023
LEU A 266
THR A 220
ILE A 226
PHE A 232
 None
 1.47A 4p6xG-6au8C:
undetectable		 4p6xG-6au8C:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e85 -

(-) 		no annotation 5 GLY A 288
ARG A 182
THR A 107
ILE A 118
PHE A 291
 None
 1.15A 4p6xG-6e85A:
undetectable		 4p6xG-6e85A:
undetectable