SIMILAR PATTERNS OF AMINO ACIDS FOR 4P6X_G_HCYG900

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi) 		PF00365
(PFK) 		5 ASN A 456
GLY A 457
GLN A 197
LEU A  73
ILE A  28
 None
 1.35A 4p6xG-1kzhA:
undetectable		 4p6xG-1kzhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 TRP A 324
LEU A 249
THR A 338
ILE A 150
PHE A 158
 None
 1.43A 4p6xG-1nxkA:
undetectable		 4p6xG-1nxkA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 ASN A 213
GLN A 188
THR A  35
ILE A 109
PHE A 192
 None
 1.15A 4p6xG-1rj6A:
undetectable		 4p6xG-1rj6A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		5 GLY B 234
GLN B 200
GLN B 210
ILE B 367
PHE B 239
 None
 1.22A 4p6xG-1wdwB:
undetectable		 4p6xG-1wdwB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zov MONOMERIC SARCOSINE
OXIDASE

(Bacillus sp.
NS-129) 		PF01266
(DAO) 		5 GLY A 263
LEU A 298
MET A 302
THR A  87
PHE A 259
 None
 1.43A 4p6xG-1zovA:
undetectable		 4p6xG-1zovA:
18.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
PHE A 891
 BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
None
 0.86A 4p6xG-2ax9A:
32.2		 4p6xG-2ax9A:
49.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLY A 708
GLN A 711
MET A 742
ARG A 752
MET A 787
 BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
 0.93A 4p6xG-2ax9A:
32.2		 4p6xG-2ax9A:
49.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 GLY A 103
LEU A 374
GLN A  81
THR A  84
PHE A 145
 None
None
PLP  A1202 (-4.5A)
None
None
 1.47A 4p6xG-2cb1A:
undetectable		 4p6xG-2cb1A:
22.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 ASN A  33
GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
MET A 115
THR A 208
 1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
None
1CA  A 247 ( 3.8A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 ( 3.7A)
1CA  A 247 (-3.4A)
 0.72A 4p6xG-2q3yA:
36.2		 4p6xG-2q3yA:
63.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 ASN A  33
GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
THR A 208
PHE A 219
 1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
None
1CA  A 247 ( 3.8A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 0.51A 4p6xG-2q3yA:
36.2		 4p6xG-2q3yA:
63.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  37
TRP A  69
THR A 208
PHE A 219
 1CA  A 247 (-2.9A)
None
None
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 1.01A 4p6xG-2q3yA:
36.2		 4p6xG-2q3yA:
63.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgz HEME OXYGENASE 2

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		5 MET A 158
LEU A  97
MET A 206
THR A  41
PHE A 227
 None
None
None
None
HEM  A 300 (-4.1A)
 1.46A 4p6xG-2rgzA:
undetectable		 4p6xG-2rgzA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE

(Paraburkholderia
xenovorans) 		PF12697
(Abhydrolase_6) 		5 GLY A  19
MET A  82
LEU A  88
ILE A  25
PHE A  23
 None
 1.33A 4p6xG-2ri6A:
undetectable		 4p6xG-2ri6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 MET A 467
LEU A 455
MET A 395
THR A 502
ILE A 503
 None
 1.19A 4p6xG-2x0qA:
undetectable		 4p6xG-2x0qA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3

(Homo sapiens) 		PF00782
(DSPc) 		5 LEU A 177
ARG A 176
GLN A 143
THR A  34
ILE A  37
 None
 1.49A 4p6xG-3f81A:
undetectable		 4p6xG-3f81A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 GLY A 891
LEU A 869
MET A 952
THR A1068
ILE A1075
 None
 1.43A 4p6xG-3fawA:
undetectable		 4p6xG-3fawA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fiu NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Francisella
tularensis) 		PF02540
(NAD_synthase) 		5 ASN A  66
GLY A 195
GLN A 200
LEU A 113
GLN A  91
 AMP  A3001 ( 3.7A)
None
None
None
None
 1.29A 4p6xG-3fiuA:
undetectable		 4p6xG-3fiuA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLY A 540
GLN A 543
GLN A 640
THR A 566
ILE A 793
 None
 1.26A 4p6xG-3ho8A:
undetectable		 4p6xG-3ho8A:
11.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 719
GLY A 722
LEU A 782
THR A 894
PHE A 905
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
None
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 1.49A 4p6xG-3kbaA:
35.0		 4p6xG-3kbaA:
54.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 ASN A 719
GLY A 722
MET A 756
LEU A 763
ARG A 766
MET A 801
THR A 894
PHE A 905
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.81A 4p6xG-3kbaA:
35.0		 4p6xG-3kbaA:
54.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 719
TRP A 755
MET A 756
LEU A 763
MET A 801
THR A 894
PHE A 905
 WOW  A   1 (-3.3A)
None
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 1.16A 4p6xG-3kbaA:
35.0		 4p6xG-3kbaA:
54.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLY A 722
GLN A 725
MET A 756
LEU A 763
ARG A 766
MET A 801
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
 0.90A 4p6xG-3kbaA:
35.0		 4p6xG-3kbaA:
54.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		5 TRP A 686
LEU A 608
THR A 700
ILE A 510
PHE A 516
 None
 1.40A 4p6xG-3kn5A:
undetectable		 4p6xG-3kn5A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0o MONOMERIC SARCOSINE
OXIDASE

(Bacillus sp.
B-0618) 		PF01266
(DAO) 		5 GLY A 263
LEU A 298
MET A 302
THR A  87
PHE A 259
 None
 1.48A 4p6xG-3m0oA:
undetectable		 4p6xG-3m0oA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672

(Caulobacter
vibrioides) 		PF01979
(Amidohydro_1) 		5 GLY A 217
LEU A 275
THR A 301
ILE A 347
PHE A 219
 M3R  A 430 (-3.5A)
None
None
M3R  A 430 ( 4.9A)
M3R  A 430 (-4.3A)
 1.41A 4p6xG-3mtwA:
undetectable		 4p6xG-3mtwA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 152
LEU A 177
THR A 116
ILE A 118
PHE A 236
 None
 1.34A 4p6xG-3oc4A:
undetectable		 4p6xG-3oc4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnb OXACILLINASE

(Escherichia
coli) 		PF00905
(Transpeptidase) 		5 GLY A 110
GLN A 113
LEU A 192
ILE A 123
PHE A  90
 None
 1.17A 4p6xG-3qnbA:
undetectable		 4p6xG-3qnbA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE

(Ralstonia
pickettii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A  85
GLN A  88
LEU A 288
THR A  40
ILE A  78
 None
None
None
None
CL  A 405 (-4.4A)
 1.09A 4p6xG-3rr1A:
undetectable		 4p6xG-3rr1A:
20.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		9 ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
MET A 115
THR A 208
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.2A)
 0.72A 4p6xG-3ry9A:
36.0		 4p6xG-3ry9A:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		9 ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.42A 4p6xG-3ry9A:
36.0		 4p6xG-3ry9A:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  37
TRP A  69
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
None
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.98A 4p6xG-3ry9A:
36.0		 4p6xG-3ry9A:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgf MALTO-OLIGOSYLTREHAL
OSE TREHALOHYDROLASE

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF09071
(Alpha-amyl_C) 		5 GLY A 116
LEU A 465
MET A 415
ILE A 141
PHE A 118
 GOL  A1101 (-3.7A)
None
None
None
None
 1.31A 4p6xG-3vgfA:
undetectable		 4p6xG-3vgfA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		5 GLY A 475
LEU A 388
GLN A 355
THR A 351
ILE A 533
 None
 1.18A 4p6xG-4c22A:
undetectable		 4p6xG-4c22A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		5 GLY B 293
LEU B 246
ARG A 317
GLN B 228
THR A 413
 None
 1.34A 4p6xG-4cakB:
undetectable		 4p6xG-4cakB:
16.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ASN A 564
GLY A 567
GLN A 570
TRP A 600
MET A 601
LEU A 608
ARG A 611
MET A 646
THR A 739
ILE A 747
PHE A 749
 MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
 0.42A 4p6xG-4p6wA:
40.5		 4p6xG-4p6wA:
98.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 564
GLY A 567
LEU A 627
THR A 739
PHE A 749
 MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
None
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
 1.42A 4p6xG-4p6wA:
40.5		 4p6xG-4p6wA:
98.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 564
GLY A 568
TRP A 600
MET A 601
THR A 739
ILE A 747
PHE A 749
 MOF  A 801 (-3.0A)
None
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
 0.94A 4p6xG-4p6wA:
40.5		 4p6xG-4p6wA:
98.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 601
LEU A 608
ARG A 611
GLN A 642
MET A 646
 MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
None
MOF  A 801 (-4.4A)
 0.92A 4p6xG-4p6wA:
40.5		 4p6xG-4p6wA:
98.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 ASN A 196
GLY A 194
GLN A 193
LEU A 353
THR A 579
 None
None
None
IBP  A 601 ( 4.7A)
None
 1.48A 4p6xG-4ph9A:
undetectable		 4p6xG-4ph9A:
19.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 ASN A 770
GLN A 776
TRP A 806
MET A 807
LEU A 814
ARG A 817
MET A 852
THR A 945
 CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-3.1A)
 0.66A 4p6xG-4udbA:
34.7		 4p6xG-4udbA:
54.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 ASN A 770
GLN A 776
TRP A 806
MET A 807
LEU A 814
ARG A 817
THR A 945
PHE A 956
 CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 0.36A 4p6xG-4udbA:
34.7		 4p6xG-4udbA:
54.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 770
GLY A 774
TRP A 806
THR A 945
PHE A 956
 CV7  A1987 (-3.1A)
None
None
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 1.09A 4p6xG-4udbA:
34.7		 4p6xG-4udbA:
54.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az0 UNCHARACTERIZED
PROTEIN

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		5 MET A 248
LEU A 243
MET A 229
ILE A 290
PHE A 293
 None
 1.23A 4p6xG-5az0A:
undetectable		 4p6xG-5az0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E

(Homo sapiens) 		PF00777
(Glyco_transf_29) 		5 GLY A 302
LEU A 299
GLN A 100
THR A 372
ILE A 316
 CDP  A 411 (-3.3A)
None
None
None
None
 1.37A 4p6xG-5bo6A:
undetectable		 4p6xG-5bo6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g6r IMINE REDUCTASE

(Aspergillus
oryzae) 		PF03446
(NAD_binding_2) 		5 ASN A  93
GLY A  94
GLN A  98
LEU A 102
ILE A 118
 NDP  A1000 (-3.5A)
None
None
None
NDP  A1000 (-4.3A)
 1.48A 4p6xG-5g6rA:
undetectable		 4p6xG-5g6rA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m23 WD REPEAT-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40) 		5 GLY A 183
GLN A 140
LEU A 143
ILE A 197
PHE A 222
 None
 1.50A 4p6xG-5m23A:
undetectable		 4p6xG-5m23A:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 8 ASN A 770
GLN A 776
TRP A 806
MET A 807
LEU A 814
ARG A 817
THR A 945
PHE A 956
 ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 0.48A 4p6xG-5mwpA:
34.8		 4p6xG-5mwpA:
45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 ASN A 770
GLY A 774
TRP A 806
THR A 945
PHE A 956
 ECV  A1101 (-3.1A)
None
None
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 1.02A 4p6xG-5mwpA:
34.8		 4p6xG-5mwpA:
45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 6 GLN A 776
TRP A 806
MET A 807
LEU A 814
ARG A 817
MET A 852
 ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
 1.22A 4p6xG-5mwpA:
34.8		 4p6xG-5mwpA:
45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 ASN A 560
GLY A 563
GLN A 566
LEU A 604
ARG A 607
GLN A 638
 486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
486  A 801 (-4.6A)
 0.64A 4p6xG-5uc1A:
26.7		 4p6xG-5uc1A:
96.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 7 ASN A 560
GLY A 563
GLN A 566
MET A 597
LEU A 604
ARG A 607
MET A 642
 486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
486  A 801 ( 3.8A)
 0.73A 4p6xG-5uc1A:
26.7		 4p6xG-5uc1A:
96.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 7 GLY A 563
GLN A 566
TRP A 596
MET A 597
LEU A 604
ARG A 607
MET A 642
 486  A 801 (-3.7A)
486  A 801 (-2.8A)
None
CPS  A 803 ( 3.9A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
486  A 801 ( 3.8A)
 0.75A 4p6xG-5uc1A:
26.7		 4p6xG-5uc1A:
96.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		10 ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
MET A 115
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
None
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 0.44A 4p6xG-5ufsA:
38.8		 4p6xG-5ufsA:
76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  36
LEU A  96
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
None
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 1.42A 4p6xG-5ufsA:
38.8		 4p6xG-5ufsA:
76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 ASN A  33
GLY A  37
TRP A  69
MET A  70
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
None
None
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 0.89A 4p6xG-5ufsA:
38.8		 4p6xG-5ufsA:
76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
GLN A 111
MET A 115
 1TA  A 301 (-3.0A)
None
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
None
1TA  A 301 ( 2.8A)
 1.05A 4p6xG-5ufsA:
38.8		 4p6xG-5ufsA:
76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C

(Homo sapiens) 		no annotation 5 ASN C 479
GLY C 482
LEU C 546
ARG C 549
MET C 525
 None
 1.47A 4p6xG-5yh3C:
undetectable		 4p6xG-5yh3C:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aom ENDOPLASMIN

(Canis lupus) 		no annotation 5 GLY A 193
LEU A  93
THR A 171
ILE A 166
PHE A 195
 None
 1.38A 4p6xG-6aomA:
undetectable		 4p6xG-6aomA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au8 GOLGI TO ER TRAFFIC
PROTEIN 4 HOMOLOG
LARGE PROLINE-RICH
PROTEIN BAG6

(Homo sapiens) 		no annotation 5 GLN C1023
LEU A 266
THR A 220
ILE A 226
PHE A 232
 None
 1.47A 4p6xG-6au8C:
undetectable		 4p6xG-6au8C:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e85 -

(-) 		no annotation 5 GLY A 288
ARG A 182
THR A 107
ILE A 118
PHE A 291
 None
 1.15A 4p6xG-6e85A:
undetectable		 4p6xG-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 LEU A 322
MET A 393
TYR A 301
 None
 0.70A 4p6xG-1bhgA:
0.0		 4p6xG-1bhgA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		3 LEU A 506
MET A 460
TYR A 501
 None
 0.87A 4p6xG-1c7tA:
undetectable		 4p6xG-1c7tA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2e ELONGATION FACTOR TU
(EF-TU)

(Bos taurus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 LEU A 406
MET A 378
TYR A 357
 None
 0.78A 4p6xG-1d2eA:
undetectable		 4p6xG-1d2eA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drt CLAVAMINATE SYNTHASE
1

(Streptomyces
clavuligerus) 		PF02668
(TauD) 		3 LEU A 159
MET A  94
TYR A 124
 AKG  A 326 (-4.9A)
None
None
 0.78A 4p6xG-1drtA:
undetectable		 4p6xG-1drtA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		3 LEU A 405
MET A 401
TYR A 342
 None
 0.86A 4p6xG-1e6zA:
0.0		 4p6xG-1e6zA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h14 ENDO-1,4-BETA-XYLANA
SE

(Pseudoalteromonas
haloplanktis) 		PF01270
(Glyco_hydro_8) 		3 LEU A  20
MET A 390
TYR A  17
 None
 0.92A 4p6xG-1h14A:
0.6		 4p6xG-1h14A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		3 LEU A 360
MET A 356
TYR A 303
 None
AMI  A1388 (-4.0A)
None
 0.96A 4p6xG-1hkkA:
0.0		 4p6xG-1hkkA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		3 LEU S 541
MET S 602
TYR S 663
 None
 0.93A 4p6xG-1i84S:
undetectable		 4p6xG-1i84S:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jal YCHF PROTEIN

(Haemophilus
influenzae) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		3 LEU A 137
MET A 177
TYR A 194
 None
 0.79A 4p6xG-1jalA:
0.0		 4p6xG-1jalA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 LEU A2520
MET A2578
TYR A2593
 None
 0.91A 4p6xG-1js8A:
undetectable		 4p6xG-1js8A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krh BENZOATE
1,2-DIOXYGENASE
REDUCTASE

(Acinetobacter
sp.) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 LEU A  26
MET A  39
TYR A  79
 None
FES  A 500 (-3.8A)
None
 0.66A 4p6xG-1krhA:
undetectable		 4p6xG-1krhA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ECDYSONE RECEPTOR

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		3 LEU D 421
MET D 381
TYR D 428
 None
HWG  D2000 ( 4.2A)
None
 0.70A 4p6xG-1r20D:
20.9		 4p6xG-1r20D:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9h PROBABLE GTPASE ENGC

(Bacillus
subtilis) 		PF03193
(RsgA_GTPase)
PF16745
(RsgA_N) 		3 LEU A  60
MET A   1
TYR A  47
 None
 0.71A 4p6xG-1t9hA:
undetectable		 4p6xG-1t9hA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9p PARC

(Escherichia
coli) 		PF03869
(Arc) 		3 LEU A  23
MET A  98
TYR A  49
 None
 0.95A 4p6xG-1u9pA:
undetectable		 4p6xG-1u9pA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		3 LEU A  33
MET A   4
TYR A  39
 None
 0.76A 4p6xG-1upxA:
undetectable		 4p6xG-1upxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5k MICROTUBULE-ASSOCIAT
ED PROTEIN, RP/EB
FAMILY, MEMBER 1

(Mus musculus) 		PF00307
(CH) 		3 LEU A  44
MET A  78
TYR A  37
 None
 0.73A 4p6xG-1v5kA:
undetectable		 4p6xG-1v5kA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjz ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		3 LEU A 291
MET A  33
TYR A 329
 None
 0.83A 4p6xG-1vjzA:
undetectable		 4p6xG-1vjzA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9q 4M5.3
ANTI-FLUORESCEIN
SINGLE CHAIN
ANTIBODY FRAGMENT

(Homo sapiens) 		PF07686
(V-set) 		3 LEU A 259
MET A 185
TYR A 247
 None
 0.75A 4p6xG-1x9qA:
undetectable		 4p6xG-1x9qA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxi DNA POLYMERASE III
SUBUNIT GAMMA

(Escherichia
coli) 		PF12169
(DNA_pol3_gamma3)
PF13177
(DNA_pol3_delta2) 		3 LEU B 288
MET B 294
TYR B 328
 None
 0.79A 4p6xG-1xxiB:
undetectable		 4p6xG-1xxiB:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0l 33H1 FV FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		3 LEU D  46
MET D 105
TYR C  87
 None
 0.84A 4p6xG-2a0lD:
undetectable		 4p6xG-2a0lD:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Homo sapiens) 		PF01869
(BcrAD_BadFG) 		3 LEU A 264
MET A 305
TYR A 341
 None
 0.77A 4p6xG-2ch6A:
undetectable		 4p6xG-2ch6A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2do8 UPF0301 PROTEIN
HD_1794

([Haemophilus]
ducreyi) 		PF02622
(DUF179) 		3 LEU A 158
MET A 173
TYR A 163
 None
 0.82A 4p6xG-2do8A:
undetectable		 4p6xG-2do8A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec2 136AA LONG
HYPOTHETICAL
TRANSPOSASE

(Sulfurisphaera
tokodaii) 		PF01797
(Y1_Tnp) 		3 LEU A  54
MET A  57
TYR A  35
 None
 0.91A 4p6xG-2ec2A:
undetectable		 4p6xG-2ec2A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5a PROTEIN (ANTIBODY
2F5 (HEAVY CHAIN))
PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LEU H  47
MET H 119
TYR L  86
 None
 0.95A 4p6xG-2f5aH:
undetectable		 4p6xG-2f5aH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fp7 GENOME POLYPROTEIN

(West Nile virus) 		PF00949
(Peptidase_S7) 		3 LEU B 149
MET B  97
TYR B  23
 None
 0.95A 4p6xG-2fp7B:
undetectable		 4p6xG-2fp7B:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggv NON-STRUCTURAL
PROTEIN 3

(West Nile virus) 		PF00949
(Peptidase_S7) 		3 LEU B 149
MET B  97
TYR B  23
 None
 0.90A 4p6xG-2ggvB:
undetectable		 4p6xG-2ggvB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		3 LEU A  17
MET A 213
TYR A 179
 None
 0.66A 4p6xG-2i5gA:
undetectable		 4p6xG-2i5gA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LEU A 321
MET A 397
TYR A 328
 GOL  A   6 (-3.8A)
None
None
 0.85A 4p6xG-2i6tA:
undetectable		 4p6xG-2i6tA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsz PROBABLE THIOL
PEROXIDASE

(Bacillus
subtilis) 		PF08534
(Redoxin) 		3 LEU A  30
MET A 111
TYR A  80
 None
 0.96A 4p6xG-2jszA:
undetectable		 4p6xG-2jszA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxx ECDYSONE RECEPTOR
(ECR, NRH1)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		3 LEU E 440
MET E 400
TYR E 447
 None
P1A  E   5 ( 4.4A)
None
 0.60A 4p6xG-2nxxE:
22.5		 4p6xG-2nxxE:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug) 		3 LEU A 237
MET A 240
TYR A 352
 None
 0.90A 4p6xG-2o5pA:
undetectable		 4p6xG-2o5pA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzv NFNB PROTEIN

(Mycolicibacterium
smegmatis) 		PF00881
(Nitroreductase) 		3 LEU A 201
MET A 159
TYR A  92
 None
 0.91A 4p6xG-2wzvA:
undetectable		 4p6xG-2wzvA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		3 LEU A 736
MET A 791
TYR A 777
 None
 0.94A 4p6xG-2xvgA:
undetectable		 4p6xG-2xvgA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyv TYROSINE-ESTER
SULFOTRANSFERASE

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		3 LEU X 113
MET X  82
TYR X  46
 None
 0.89A 4p6xG-2zyvX:
undetectable		 4p6xG-2zyvX:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 168
MET A 122
TYR A 102
 None
 0.90A 4p6xG-3a62A:
undetectable		 4p6xG-3a62A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Escherichia
coli) 		PF06751
(EutB) 		3 LEU A 346
MET A 351
TYR A 136
 None
 0.93A 4p6xG-3anyA:
undetectable		 4p6xG-3anyA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		3 LEU A 686
MET A 662
TYR A 608
 None
 0.56A 4p6xG-3ayfA:
undetectable		 4p6xG-3ayfA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		3 LEU A 115
MET A 118
TYR A  41
 None
 0.95A 4p6xG-3dxxA:
undetectable		 4p6xG-3dxxA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e20 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Schizosaccharomyces
pombe) 		no annotation 3 LEU C 318
MET C 412
TYR C 381
 None
 0.88A 4p6xG-3e20C:
undetectable		 4p6xG-3e20C:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgt PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM

(Mus musculus) 		PF04916
(Phospholip_B) 		3 LEU B 252
MET B 477
TYR B 486
 None
None
GOL  B   5 (-4.2A)
 0.62A 4p6xG-3fgtB:
undetectable		 4p6xG-3fgtB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg2 SUGAR DEHYDROGENASE,
UDP-GLUCOSE/GDP-MANN
OSE DEHYDROGENASE
FAMILY

(Porphyromonas
gingivalis) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		3 LEU A  91
MET A 132
TYR A 125
 None
 0.70A 4p6xG-3gg2A:
undetectable		 4p6xG-3gg2A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv1 POLAR AMINO ACID ABC
UPTAKE TRANSPORTER
SUBSTRATE BINDING
PROTEIN

(Streptococcus
thermophilus) 		PF00497
(SBP_bac_3) 		3 LEU A 203
MET A 225
TYR A 208
 None
 0.85A 4p6xG-3hv1A:
undetectable		 4p6xG-3hv1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		3 LEU A 541
MET A 602
TYR A 663
 None
 0.97A 4p6xG-3j04A:
undetectable		 4p6xG-3j04A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olq UNIVERSAL STRESS
PROTEIN E

(Proteus
mirabilis) 		PF00582
(Usp) 		3 LEU A 111
MET A 144
TYR A  26
 None
None
UNL  A 321 ( 3.8A)
 0.74A 4p6xG-3olqA:
undetectable		 4p6xG-3olqA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pw3 AMINOPEPTIDASE C

(Parabacteroides
distasonis) 		PF03051
(Peptidase_C1_2) 		3 LEU A 219
MET A 253
TYR A 264
 None
 0.75A 4p6xG-3pw3A:
undetectable		 4p6xG-3pw3A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q13 SPONDIN-1

(Homo sapiens) 		PF06468
(Spond_N) 		3 LEU A 350
MET A 320
TYR A 212
 None
None
NAG  A 502 ( 3.8A)
 0.93A 4p6xG-3q13A:
undetectable		 4p6xG-3q13A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qna 6-CARBOXY-5,6,7,8-TE
TRAHYDROPTERIN
SYNTHASE

(Escherichia
coli) 		PF01242
(PTPS) 		3 LEU A  38
MET A  35
TYR A 117
 None
 0.83A 4p6xG-3qnaA:
undetectable		 4p6xG-3qnaA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtg PYRUVATE KINASE

(Pyrobaculum
aerophilum) 		PF00224
(PK)
PF02887
(PK_C) 		3 LEU A 432
MET A 382
TYR A 400
 None
 0.86A 4p6xG-3qtgA:
undetectable		 4p6xG-3qtgA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli) 		no annotation 3 LEU M 190
MET M 136
TYR M 197
 None
 0.85A 4p6xG-3rkoM:
1.9		 4p6xG-3rkoM:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		3 LEU A 425
MET A 462
TYR A 447
 None
 0.84A 4p6xG-3ua4A:
undetectable		 4p6xG-3ua4A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr1 PEPTIDE CHAIN
RELEASE FACTOR 3

(Desulfovibrio
vulgaris) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF16658
(RF3_C) 		3 LEU A  85
MET A  41
TYR A  78
 None
 0.57A 4p6xG-3vr1A:
undetectable		 4p6xG-3vr1A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vs8 TYPE III POLYKETIDE
SYNTHASE

(Azotobacter
vinelandii) 		PF02797
(Chal_sti_synt_C) 		3 LEU A 241
MET A 293
TYR A  67
 None
 0.93A 4p6xG-3vs8A:
undetectable		 4p6xG-3vs8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh9 ENDO-BETA-1,4-MANNAN
ASE

(Aspergillus
niger) 		PF00150
(Cellulase) 		3 LEU A 224
MET A 228
TYR A 218
 None
NAG  A 402 (-4.3A)
None
 0.74A 4p6xG-3wh9A:
undetectable		 4p6xG-3wh9A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blq P4

(Pseudomonas
phage phi8) 		PF11602
(NTPase_P4) 		3 LEU A 132
MET A 209
TYR A 123
 None
 0.80A 4p6xG-4blqA:
undetectable		 4p6xG-4blqA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwc PHOSPHOLIPASE B-LIKE
1

(Bos taurus) 		PF04916
(Phospholip_B) 		3 LEU B 228
MET B 444
TYR B 453
 None
 0.73A 4p6xG-4bwcB:
undetectable		 4p6xG-4bwcB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwy P4

(Pseudomonas
phage phi8) 		PF11602
(NTPase_P4) 		3 LEU A 132
MET A 209
TYR A 123
 None
 0.81A 4p6xG-4bwyA:
undetectable		 4p6xG-4bwyA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT

(Vaccinia virus) 		PF03341
(Pox_mRNA-cap) 		3 LEU B 160
MET B 135
TYR B  39
 None
 0.91A 4p6xG-4ckeB:
undetectable		 4p6xG-4ckeB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emw COENZYME A DISULFIDE
REDUCTASE

(Staphylococcus
aureus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 LEU A 370
MET A 350
TYR A 435
 None
 0.71A 4p6xG-4emwA:
undetectable		 4p6xG-4emwA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frt PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		3 LEU A 367
MET A 324
TYR A 353
 None
 0.88A 4p6xG-4frtA:
undetectable		 4p6xG-4frtA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LEU H  47
MET H 106
TYR L  86
 None
 0.96A 4p6xG-4hjjH:
undetectable		 4p6xG-4hjjH:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		3 LEU A 258
MET A 314
TYR A 249
 None
 0.93A 4p6xG-4j3qA:
undetectable		 4p6xG-4j3qA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		3 LEU A 196
MET A 141
TYR A 125
 None
 0.89A 4p6xG-4j5tA:
undetectable		 4p6xG-4j5tA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lim DNA PRIMASE SMALL
SUBUNIT

(Saccharomyces
cerevisiae) 		PF01896
(DNA_primase_S) 		3 LEU A 245
MET A 307
TYR A 250
 None
 0.91A 4p6xG-4limA:
undetectable		 4p6xG-4limA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmw GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		3 LEU A 105
MET A 196
TYR A 118
 None
 0.84A 4p6xG-4lmwA:
undetectable		 4p6xG-4lmwA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvu ION TRANSPORT
PROTEIN

(Arcobacter
butzleri) 		PF00520
(Ion_trans) 		3 LEU A1024
MET A1029
TYR A1044
 None
 0.96A 4p6xG-4mvuA:
undetectable		 4p6xG-4mvuA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF13439
(Glyco_transf_4)
PF13692
(Glyco_trans_1_4) 		3 LEU A 280
MET A 260
TYR A 336
 None
 0.95A 4p6xG-4n9wA:
undetectable		 4p6xG-4n9wA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntm 6-CARBOXY-5,6,7,8-TE
TRAHYDROPTERIN
SYNTHASE

(Escherichia
coli) 		PF01242
(PTPS) 		3 LEU A  39
MET A  36
TYR A 118
 None
 0.83A 4p6xG-4ntmA:
undetectable		 4p6xG-4ntmA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozr ECDYSONE RECEPTOR

(Pediculus
humanus) 		PF00104
(Hormone_recep) 		3 LEU E 413
MET E 373
TYR E 420
 None
 0.67A 4p6xG-4ozrE:
18.4		 4p6xG-4ozrE:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt ECDYSONE RECEPTOR

(Pediculus
humanus) 		PF00104
(Hormone_recep) 		3 LEU E 413
MET E 373
TYR E 420
 None
P1A  E 601 ( 4.4A)
None
 0.63A 4p6xG-4oztE:
22.3		 4p6xG-4oztE:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qd2 HEMAGGLUTININ
COMPONENT HA70

(Clostridium
botulinum) 		PF03505
(Clenterotox) 		3 LEU A 474
MET A 508
TYR A 432
 None
 0.90A 4p6xG-4qd2A:
undetectable		 4p6xG-4qd2A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uop LIPOTEICHOIC ACID
PRIMASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		3 LEU A 520
MET A 513
TYR A 222
 None
 0.89A 4p6xG-4uopA:
undetectable		 4p6xG-4uopA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT

(Escherichia
coli) 		PF01555
(N6_N4_Mtase) 		3 LEU A 545
MET A 513
TYR A 552
 None
 0.67A 4p6xG-4zcfA:
undetectable		 4p6xG-4zcfA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F

(Pseudomonas
aeruginosa) 		PF00497
(SBP_bac_3)
PF01464
(SLT) 		3 LEU B 189
MET B 154
TYR B 135
 None
 0.84A 4p6xG-5aa4B:
undetectable		 4p6xG-5aa4B:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq6 METAL-BINDING
PROTEIN ZINT

(Escherichia
coli) 		PF09223
(ZinT) 		3 LEU A  51
MET A 191
TYR A  73
 None
 0.83A 4p6xG-5aq6A:
undetectable		 4p6xG-5aq6A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aum HEAVY CHAIN OF FAB
FRAGMENT

(Rattus) 		no annotation 3 LEU H   4
MET H  77
TYR H  35
 None
 0.95A 4p6xG-5aumH:
undetectable		 4p6xG-5aumH:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1

(Thielavia
terrestris) 		PF05183
(RdRP) 		3 LEU A 857
MET A 952
TYR A 942
 None
 0.81A 4p6xG-5fswA:
undetectable		 4p6xG-5fswA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		3 LEU B 873
MET B 877
TYR B 846
 None
 0.81A 4p6xG-5gjeB:
undetectable		 4p6xG-5gjeB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gka CAPSID PROTEIN VP0

(Aichivirus A) 		PF00073
(Rhv) 		3 LEU B 228
MET B 199
TYR B 236
 None
 0.96A 4p6xG-5gkaB:
undetectable		 4p6xG-5gkaB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h34 METHIONINE-TRNA
LIGASE

(Nanoarchaeum
equitans) 		PF01588
(tRNA_bind) 		3 LEU A 751
MET A 682
TYR A 730
 None
 0.82A 4p6xG-5h34A:
undetectable		 4p6xG-5h34A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpi P-HYDROXYBENZOATE
HYDROXYLASE
TRANSCRIPTIONAL
ACTIVATOR

(Acinetobacter
sp. ADP1) 		PF01614
(IclR) 		3 LEU A 238
MET A 241
TYR A 209
 None
3HB  A 301 (-3.5A)
None
 0.92A 4p6xG-5hpiA:
undetectable		 4p6xG-5hpiA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idk GENOME
POLYPROTEIN,SERINE
PROTEASE SUBUNIT
NS2B, SERINE
PROTEASE NS3

(West Nile virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		3 LEU A1149
MET A1097
TYR A1023
 None
 0.91A 4p6xG-5idkA:
undetectable		 4p6xG-5idkA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knm CDNA FLJ39643 FIS,
CLONE SMINT2004023,
HIGHLY SIMILAR TO
HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHACHAIN
F

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 LEU A   5
MET A  98
TYR A 159
 None
 0.73A 4p6xG-5knmA:
undetectable		 4p6xG-5knmA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		3 LEU A1608
MET A1758
TYR A1595
 None
 0.94A 4p6xG-5lkiA:
undetectable		 4p6xG-5lkiA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 3 LEU A 568
MET A 577
TYR A  33
 None
 0.90A 4p6xG-5nqdA:
undetectable		 4p6xG-5nqdA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nr4 CLIP-ASSOCIATING
PROTEIN 2

(Homo sapiens) 		no annotation 3 LEU A  97
MET A 120
TYR A  89
 None
 0.88A 4p6xG-5nr4A:
undetectable		 4p6xG-5nr4A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nr4 CLIP-ASSOCIATING
PROTEIN 2

(Homo sapiens) 		no annotation 3 LEU A 115
MET A 120
TYR A  89
 None
 0.85A 4p6xG-5nr4A:
undetectable		 4p6xG-5nr4A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 3 LEU A 258
MET A 314
TYR A 249
 None
 0.95A 4p6xG-5or4A:
undetectable		 4p6xG-5or4A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E) 		PF00073
(Rhv) 		3 LEU C  98
MET C  94
TYR C 105
 None
 0.92A 4p6xG-5osnC:
undetectable		 4p6xG-5osnC:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 LEU A 524
MET A 549
TYR A 543
 None
 0.75A 4p6xG-5t9gA:
undetectable		 4p6xG-5t9gA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whr INDOLEAMINE
2,3-DIOXYGENASE 1

(Homo sapiens) 		no annotation 3 LEU A  83
MET A  40
TYR A  90
 None
 0.84A 4p6xG-5whrA:
undetectable		 4p6xG-5whrA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x89 ENDA-LIKE
PROTEIN,TRNA-SPLICIN
G ENDONUCLEASE

(Methanopyrus
kandleri) 		no annotation 3 LEU A 255
MET A 249
TYR A 232
 None
 0.96A 4p6xG-5x89A:
undetectable		 4p6xG-5x89A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 LEU A 305
MET A 248
TYR A 254
 None
 0.95A 4p6xG-5xbpA:
undetectable		 4p6xG-5xbpA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xep CHITINASE-3-LIKE
PROTEIN 1

(Mus musculus) 		no annotation 3 LEU A 355
MET A 351
TYR A 297
 None
 0.90A 4p6xG-5xepA:
undetectable		 4p6xG-5xepA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyb -

(-) 		no annotation 3 LEU A 274
MET A 268
TYR A 234
 None
 0.92A 4p6xG-5xybA:
undetectable		 4p6xG-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yf0 -

(-) 		no annotation 3 LEU A 162
MET A 234
TYR A 251
 None
SAM  A 505 (-4.2A)
None
 0.71A 4p6xG-5yf0A:
undetectable		 4p6xG-5yf0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 3 LEU A 227
MET A 143
TYR A 234
 None
OLC  A1207 ( 3.9A)
None
 0.51A 4p6xG-6bqhA:
undetectable		 4p6xG-6bqhA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 SODIUM-COUPLED
NEUTRAL AMINO ACID
TRANSPORTER 9

(Danio rerio) 		no annotation 3 LEU C 535
MET C 145
TYR C 154
 None
 0.94A 4p6xG-6c08C:
undetectable		 4p6xG-6c08C:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccb GLYCOPROTEIN 120

(Human
immunodeficiency
virus 1) 		no annotation 3 LEU C 175
MET C 172
TYR C 191
 None
 0.92A 4p6xG-6ccbC:
undetectable		 4p6xG-6ccbC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 3 LEU A 263
MET A 193
TYR A 176
 None
 0.68A 4p6xG-6cmjA:
undetectable		 4p6xG-6cmjA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv0 SPIKE GLYCOPROTEIN

(Avian
coronavirus) 		no annotation 3 LEU A 169
MET A  83
TYR A  30
 None
 0.78A 4p6xG-6cv0A:
undetectable		 4p6xG-6cv0A:
15.89