SIMILAR PATTERNS OF AMINO ACIDS FOR 4P65_K_IPHK101_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		5 VAL A 139
LEU A 182
CYH A 166
LEU A 165
ALA A 161
 None
 1.01A 4p65F-1a27A:
undetectable
4p65H-1a27A:
undetectable
4p65K-1a27A:
undetectable
4p65L-1a27A:
undetectable		 4p65F-1a27A:
7.17
4p65H-1a27A:
7.17
4p65K-1a27A:
5.42
4p65L-1a27A:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bd8 P19INK4D CDK4/6
INHIBITOR

(Homo sapiens) 		PF12796
(Ank_2) 		5 LEU A  46
VAL A  24
LEU A  12
ILE A  56
ALA A  65
 None
 1.04A 4p65F-1bd8A:
undetectable
4p65H-1bd8A:
undetectable
4p65K-1bd8A:
undetectable
4p65L-1bd8A:
undetectable		 4p65F-1bd8A:
10.96
4p65H-1bd8A:
10.96
4p65K-1bd8A:
6.94
4p65L-1bd8A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1esc ESTERASE

(Streptomyces
scabiei) 		PF13472
(Lipase_GDSL_2) 		5 LEU A 169
VAL A 161
ILE A  69
LEU A 183
ALA A 235
 None
 1.01A 4p65F-1escA:
undetectable
4p65H-1escA:
undetectable
4p65K-1escA:
undetectable
4p65L-1escA:
undetectable		 4p65F-1escA:
12.24
4p65H-1escA:
12.24
4p65K-1escA:
5.59
4p65L-1escA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fui L-FUCOSE ISOMERASE

(Escherichia
coli) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		6 LEU A  82
VAL A  86
ILE A  11
LEU A  41
LEU A 159
ALA A 163
 None
 1.34A 4p65F-1fuiA:
undetectable
4p65H-1fuiA:
undetectable
4p65K-1fuiA:
undetectable
4p65L-1fuiA:
undetectable		 4p65F-1fuiA:
3.76
4p65H-1fuiA:
3.76
4p65K-1fuiA:
3.09
4p65L-1fuiA:
3.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 VAL A 246
CYH A 345
LEU A 381
LEU A 373
ALA A 377
 None
 1.05A 4p65F-1gzkA:
undetectable
4p65H-1gzkA:
undetectable
4p65K-1gzkA:
undetectable
4p65L-1gzkA:
undetectable		 4p65F-1gzkA:
10.13
4p65H-1gzkA:
10.13
4p65K-1gzkA:
7.94
4p65L-1gzkA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		5 LEU A 621
VAL A 617
LEU A 711
ILE A 755
LEU A 560
 None
 1.04A 4p65F-1lnsA:
undetectable
4p65H-1lnsA:
undetectable
4p65K-1lnsA:
undetectable
4p65L-1lnsA:
undetectable		 4p65F-1lnsA:
4.01
4p65H-1lnsA:
4.01
4p65K-1lnsA:
2.72
4p65L-1lnsA:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 791
LEU A 855
CYH A 698
LEU A 702
ALA A 705
 None
 1.04A 4p65F-1lufA:
undetectable
4p65H-1lufA:
undetectable
4p65K-1lufA:
undetectable
4p65L-1lufA:
undetectable		 4p65F-1lufA:
6.34
4p65H-1lufA:
6.34
4p65K-1lufA:
4.47
4p65L-1lufA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mj0 SANK E3_5 PROTEIN

(-) 		PF12796
(Ank_2) 		5 LEU A 117
VAL A  96
LEU A  84
ILE A 128
ALA A 137
 None
 1.06A 4p65F-1mj0A:
undetectable
4p65H-1mj0A:
undetectable
4p65K-1mj0A:
undetectable
4p65L-1mj0A:
undetectable		 4p65F-1mj0A:
13.51
4p65H-1mj0A:
13.51
4p65K-1mj0A:
11.01
4p65L-1mj0A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 VAL E 160
LEU E 148
ILE E 198
LEU E 205
ALA E 207
 None
 1.05A 4p65F-1nfiE:
undetectable
4p65H-1nfiE:
undetectable
4p65K-1nfiE:
undetectable
4p65L-1nfiE:
undetectable		 4p65F-1nfiE:
11.76
4p65H-1nfiE:
11.76
4p65K-1nfiE:
7.77
4p65L-1nfiE:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qe0 HISTIDINE--TRNA
LIGASE

(Staphylococcus
aureus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 LEU A 283
ILE A 150
LEU A 156
LEU A 317
ALA A 316
 None
 1.01A 4p65F-1qe0A:
undetectable
4p65H-1qe0A:
undetectable
4p65K-1qe0A:
undetectable
4p65L-1qe0A:
undetectable		 4p65F-1qe0A:
6.37
4p65H-1qe0A:
6.37
4p65K-1qe0A:
3.10
4p65L-1qe0A:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlc POSTSYNAPTIC DENSITY
PROTEIN 95

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 LEU A 206
VAL A 215
ILE A 212
LEU A 170
ALA A 200
 None
 1.04A 4p65F-1qlcA:
undetectable
4p65H-1qlcA:
undetectable
4p65K-1qlcA:
undetectable
4p65L-1qlcA:
undetectable		 4p65F-1qlcA:
20.51
4p65H-1qlcA:
20.51
4p65K-1qlcA:
15.07
4p65L-1qlcA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svx ANKYRIN REPEAT
PROTEIN OFF7

(-) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU A  51
VAL A  30
LEU A  18
ILE A  62
ALA A  71
 None
 0.99A 4p65F-1svxA:
undetectable
4p65H-1svxA:
undetectable
4p65K-1svxA:
undetectable
4p65L-1svxA:
undetectable		 4p65F-1svxA:
12.00
4p65H-1svxA:
12.00
4p65K-1svxA:
6.59
4p65L-1svxA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svx ANKYRIN REPEAT
PROTEIN OFF7

(-) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU A 117
VAL A  96
LEU A  84
ILE A 128
ALA A 137
 None
 1.03A 4p65F-1svxA:
undetectable
4p65H-1svxA:
undetectable
4p65K-1svxA:
undetectable
4p65L-1svxA:
undetectable		 4p65F-1svxA:
12.00
4p65H-1svxA:
12.00
4p65K-1svxA:
6.59
4p65L-1svxA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttw SECRETION CHAPERONE

(Yersinia pestis) 		PF05932
(CesT) 		5 LEU A  57
CYH A  81
LEU A  91
LEU A 119
ALA A  54
 None
 0.92A 4p65F-1ttwA:
undetectable
4p65H-1ttwA:
undetectable
4p65K-1ttwA:
undetectable
4p65L-1ttwA:
undetectable		 4p65F-1ttwA:
15.05
4p65H-1ttwA:
15.05
4p65K-1ttwA:
9.35
4p65L-1ttwA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1

(Medicago
truncatula) 		PF00201
(UDPGT) 		5 CYH A  46
ILE A  15
HIS A  22
LEU A  23
ALA A  26
 None
 1.00A 4p65F-2acvA:
undetectable
4p65H-2acvA:
undetectable
4p65K-2acvA:
undetectable
4p65L-2acvA:
undetectable		 4p65F-2acvA:
5.12
4p65H-2acvA:
5.12
4p65K-2acvA:
3.77
4p65L-2acvA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8e CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 LEU A 586
VAL A 421
LEU A 561
LEU A 429
ALA A 554
 None
 1.00A 4p65F-2b8eA:
undetectable
4p65H-2b8eA:
undetectable
4p65K-2b8eA:
undetectable
4p65L-2b8eA:
undetectable		 4p65F-2b8eA:
8.13
4p65H-2b8eA:
8.13
4p65K-2b8eA:
8.70
4p65L-2b8eA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbz VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR

(Molluscum
contagiosum
virus) 		PF01335
(DED) 		5 LEU A 122
VAL A 149
LEU A 157
LEU A 126
ALA A 119
 None
 0.98A 4p65F-2bbzA:
undetectable
4p65H-2bbzA:
undetectable
4p65K-2bbzA:
undetectable
4p65L-2bbzA:
undetectable		 4p65F-2bbzA:
10.04
4p65H-2bbzA:
10.04
4p65K-2bbzA:
7.45
4p65L-2bbzA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkg SYNTHETIC CONSTRUCT
ANKYRIN REPEAT
PROTEIN E3_19

(synthetic
construct) 		PF12796
(Ank_2) 		5 LEU A 117
VAL A  96
LEU A  84
ILE A 128
ALA A 137
 None
 1.04A 4p65F-2bkgA:
undetectable
4p65H-2bkgA:
undetectable
4p65K-2bkgA:
undetectable
4p65L-2bkgA:
undetectable		 4p65F-2bkgA:
12.00
4p65H-2bkgA:
12.00
4p65K-2bkgA:
10.91
4p65L-2bkgA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		5 VAL A 162
LEU A 137
LEU A 233
LEU A 151
ALA A 154
 None
 0.85A 4p65F-2dulA:
undetectable
4p65H-2dulA:
undetectable
4p65K-2dulA:
undetectable
4p65L-2dulA:
undetectable		 4p65F-2dulA:
6.12
4p65H-2dulA:
6.12
4p65K-2dulA:
4.18
4p65L-2dulA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8l 287AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01937
(DUF89) 		5 LEU A 133
LEU A 167
CYH A 280
LEU A 259
ALA A 104
 None
 1.05A 4p65F-2g8lA:
undetectable
4p65H-2g8lA:
undetectable
4p65K-2g8lA:
undetectable
4p65L-2g8lA:
undetectable		 4p65F-2g8lA:
7.17
4p65H-2g8lA:
7.17
4p65K-2g8lA:
4.42
4p65L-2g8lA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 516
VAL A 456
LEU A 360
ILE A 455
CYH A 487
 None
 1.05A 4p65F-2hckA:
undetectable
4p65H-2hckA:
undetectable
4p65K-2hckA:
undetectable
4p65L-2hckA:
undetectable		 4p65F-2hckA:
5.84
4p65H-2hckA:
5.84
4p65K-2hckA:
4.39
4p65L-2hckA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6r VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 VAL A 138
LEU A 135
LEU A 173
LEU A 154
ALA A 184
 None
 1.05A 4p65F-2o6rA:
undetectable
4p65H-2o6rA:
undetectable
4p65K-2o6rA:
undetectable
4p65L-2o6rA:
undetectable		 4p65F-2o6rA:
8.47
4p65H-2o6rA:
8.47
4p65K-2o6rA:
8.61
4p65L-2o6rA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozg GCN5-RELATED
N-ACETYLTRANSFERASE

(Trichormus
variabilis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		6 LEU A 104
VAL A  84
LEU A  99
ILE A  81
LEU A 124
ALA A 128
 None
COA  A 500 (-3.8A)
None
None
COA  A 500 (-3.5A)
None
 1.48A 4p65F-2ozgA:
undetectable
4p65H-2ozgA:
undetectable
4p65K-2ozgA:
undetectable
4p65L-2ozgA:
undetectable		 4p65F-2ozgA:
7.39
4p65H-2ozgA:
7.39
4p65K-2ozgA:
5.59
4p65L-2ozgA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 ILE B 519
LEU B 578
HIS B 560
LEU B 561
ALA B 564
 None
 1.05A 4p65F-2rhqB:
undetectable
4p65H-2rhqB:
undetectable
4p65K-2rhqB:
undetectable
4p65L-2rhqB:
undetectable		 4p65F-2rhqB:
4.56
4p65H-2rhqB:
4.56
4p65K-2rhqB:
4.11
4p65L-2rhqB:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 LEU I 586
VAL I 421
LEU I 561
LEU I 429
ALA I 554
 None
 1.00A 4p65F-2voyI:
undetectable
4p65H-2voyI:
undetectable
4p65K-2voyI:
undetectable
4p65L-2voyI:
undetectable		 4p65F-2voyI:
15.15
4p65H-2voyI:
15.15
4p65K-2voyI:
9.89
4p65L-2voyI:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2g NON-STRUCTURAL
PROTEIN 3

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF11633
(SUD-M) 		5 LEU A 421
LEU A 412
ILE A 454
LEU A 437
ALA A 415
 None
 1.06A 4p65F-2w2gA:
undetectable
4p65H-2w2gA:
undetectable
4p65K-2w2gA:
undetectable
4p65L-2w2gA:
undetectable		 4p65F-2w2gA:
7.48
4p65H-2w2gA:
7.48
4p65K-2w2gA:
5.66
4p65L-2w2gA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x32 CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF04264
(YceI) 		5 LEU A  47
VAL A 164
LEU A  12
LEU A 104
ALA A  74
 None
OTP  A1174 ( 4.6A)
None
OTP  A1174 ( 4.5A)
OTP  A1174 ( 4.9A)
 1.05A 4p65F-2x32A:
undetectable
4p65H-2x32A:
undetectable
4p65K-2x32A:
undetectable
4p65L-2x32A:
undetectable		 4p65F-2x32A:
11.59
4p65H-2x32A:
11.59
4p65K-2x32A:
11.67
4p65L-2x32A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzd DARPIN-3.4

(synthetic
construct) 		PF12796
(Ank_2) 		5 LEU G  51
VAL G  30
LEU G  18
ILE G  62
ALA G  71
 None
 1.02A 4p65F-2xzdG:
undetectable
4p65H-2xzdG:
undetectable
4p65K-2xzdG:
undetectable
4p65L-2xzdG:
undetectable		 4p65F-2xzdG:
14.53
4p65H-2xzdG:
14.53
4p65K-2xzdG:
7.46
4p65L-2xzdG:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw2 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Aquifex
aeolicus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 LEU A 288
VAL A   5
ILE A  67
LEU A 297
ALA A 293
 None
 1.04A 4p65F-2yw2A:
undetectable
4p65H-2yw2A:
undetectable
4p65K-2yw2A:
undetectable
4p65L-2yw2A:
undetectable		 4p65F-2yw2A:
5.26
4p65H-2yw2A:
5.26
4p65K-2yw2A:
4.58
4p65L-2yw2A:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acz METHIONINE
GAMMA-LYASE

(Entamoeba
histolytica) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 324
ILE A 368
LEU A 320
LEU A 386
ALA A 385
 None
 1.05A 4p65F-3aczA:
undetectable
4p65H-3aczA:
undetectable
4p65K-3aczA:
undetectable
4p65L-3aczA:
undetectable		 4p65F-3aczA:
7.20
4p65H-3aczA:
7.20
4p65K-3aczA:
7.73
4p65L-3aczA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cit SENSOR HISTIDINE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 LEU A 148
LEU A 155
LEU A 131
LEU A  51
ALA A  54
 None
 0.98A 4p65F-3citA:
undetectable
4p65H-3citA:
undetectable
4p65K-3citA:
undetectable
4p65L-3citA:
undetectable		 4p65F-3citA:
14.41
4p65H-3citA:
14.41
4p65K-3citA:
11.90
4p65L-3citA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		5 LEU A  75
ILE A 268
LEU A 237
LEU A 259
ALA A  94
 None
 1.05A 4p65F-3cq5A:
undetectable
4p65H-3cq5A:
undetectable
4p65K-3cq5A:
undetectable
4p65L-3cq5A:
undetectable		 4p65F-3cq5A:
9.39
4p65H-3cq5A:
9.39
4p65K-3cq5A:
5.69
4p65L-3cq5A:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmn PUTATIVE DNA
HELICASE

(Lactobacillus
plantarum) 		PF13538
(UvrD_C_2) 		6 VAL A 711
CYH A 734
ILE A 660
LEU A 730
LEU A 743
ALA A 716
 None
None
ACT  A   6 ( 4.9A)
None
None
None
 1.43A 4p65F-3dmnA:
undetectable
4p65H-3dmnA:
undetectable
4p65K-3dmnA:
undetectable
4p65L-3dmnA:
undetectable		 4p65F-3dmnA:
11.80
4p65H-3dmnA:
11.80
4p65K-3dmnA:
7.79
4p65L-3dmnA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE

(Plasmodium
berghei) 		PF13561
(adh_short_C2) 		5 VAL A 183
ILE A 187
LEU A 197
HIS A 236
LEU A 233
 None
 0.95A 4p65F-3f4bA:
undetectable
4p65H-3f4bA:
undetectable
4p65K-3f4bA:
undetectable
4p65L-3f4bA:
undetectable		 4p65F-3f4bA:
8.15
4p65H-3f4bA:
8.15
4p65K-3f4bA:
6.29
4p65L-3f4bA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4z MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH ALLERGEN
DERP7

(Escherichia
coli;
Dermatophagoides
pteronyssinus) 		PF13416
(SBP_bac_8)
PF16984
(Grp7_allergen) 		5 LEU A 115
ILE A 132
LEU A 139
LEU A 122
ALA A 223
 None
 1.04A 4p65F-3h4zA:
undetectable
4p65H-3h4zA:
undetectable
4p65K-3h4zA:
undetectable
4p65L-3h4zA:
undetectable		 4p65F-3h4zA:
3.75
4p65H-3h4zA:
3.75
4p65K-3h4zA:
4.42
4p65L-3h4zA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kqf ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00378
(ECH_1) 		5 LEU A  42
LEU A  35
ILE A   7
LEU A  56
LEU A 117
 None
 1.02A 4p65F-3kqfA:
undetectable
4p65H-3kqfA:
undetectable
4p65K-3kqfA:
undetectable
4p65L-3kqfA:
undetectable		 4p65F-3kqfA:
8.30
4p65H-3kqfA:
8.30
4p65K-3kqfA:
8.07
4p65L-3kqfA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum) 		PF13458
(Peripla_BP_6) 		5 VAL A 191
LEU A 195
ILE A 159
LEU A 166
ALA A 165
 None
 1.04A 4p65F-3lopA:
undetectable
4p65H-3lopA:
undetectable
4p65K-3lopA:
undetectable
4p65L-3lopA:
undetectable		 4p65F-3lopA:
6.82
4p65H-3lopA:
6.82
4p65K-3lopA:
9.72
4p65L-3lopA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n93 MALTOSE BINDING
PROTEIN-CRFR2 ALPHA

(Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 LEU A-255
ILE A-238
LEU A-231
LEU A-248
ALA A-147
 None
 1.04A 4p65F-3n93A:
undetectable
4p65H-3n93A:
undetectable
4p65K-3n93A:
undetectable
4p65L-3n93A:
undetectable		 4p65F-3n93A:
5.70
4p65H-3n93A:
5.70
4p65K-3n93A:
3.95
4p65L-3n93A:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfv ALGINATE LYASE

(Bacteroides
ovatus) 		PF05426
(Alginate_lyase) 		5 LEU A 304
ILE A 297
LEU A 332
LEU A 365
ALA A 368
 None
 1.00A 4p65F-3nfvA:
undetectable
4p65H-3nfvA:
undetectable
4p65K-3nfvA:
undetectable
4p65L-3nfvA:
undetectable		 4p65F-3nfvA:
9.38
4p65H-3nfvA:
9.38
4p65K-3nfvA:
4.03
4p65L-3nfvA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc6 6-PHOSPHOGLUCONOLACT
ONASE

(Mycolicibacterium
smegmatis) 		PF01182
(Glucosamine_iso) 		5 LEU A  51
VAL A  40
ILE A  39
LEU A  93
ALA A  88
 None
 1.01A 4p65F-3oc6A:
undetectable
4p65H-3oc6A:
undetectable
4p65K-3oc6A:
undetectable
4p65L-3oc6A:
undetectable		 4p65F-3oc6A:
12.03
4p65H-3oc6A:
12.03
4p65K-3oc6A:
7.64
4p65L-3oc6A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		5 LEU B 431
VAL B 423
LEU B 424
LEU B 332
ALA B 314
 None
 0.99A 4p65F-3pdiB:
undetectable
4p65H-3pdiB:
undetectable
4p65K-3pdiB:
undetectable
4p65L-3pdiB:
undetectable		 4p65F-3pdiB:
6.50
4p65H-3pdiB:
6.50
4p65K-3pdiB:
7.61
4p65L-3pdiB:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9n CONSENSUS ANKYRIN
REPEAT

(Escherichia
coli) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU C  39
VAL C  18
LEU C   6
ILE C  50
ALA C  59
 None
 1.05A 4p65F-3q9nC:
undetectable
4p65H-3q9nC:
undetectable
4p65K-3q9nC:
undetectable
4p65L-3q9nC:
undetectable		 4p65F-3q9nC:
11.35
4p65H-3q9nC:
11.35
4p65K-3q9nC:
8.97
4p65L-3q9nC:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9n CONSENSUS ANKYRIN
REPEAT

(Escherichia
coli) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU C 105
VAL C  84
LEU C  72
ILE C 116
ALA C 125
 None
 1.04A 4p65F-3q9nC:
undetectable
4p65H-3q9nC:
undetectable
4p65K-3q9nC:
undetectable
4p65L-3q9nC:
undetectable		 4p65F-3q9nC:
11.35
4p65H-3q9nC:
11.35
4p65K-3q9nC:
8.97
4p65L-3q9nC:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 LEU A 152
VAL A 199
LEU A 160
LEU A 236
LEU A 228
 None
 1.03A 4p65F-3rv2A:
undetectable
4p65H-3rv2A:
undetectable
4p65K-3rv2A:
undetectable
4p65L-3rv2A:
undetectable		 4p65F-3rv2A:
5.56
4p65H-3rv2A:
5.56
4p65K-3rv2A:
7.47
4p65L-3rv2A:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdi PROTEASOME COMPONENT
PRE5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 LEU E 107
HIS E  73
CYH E  70
LEU E  92
ALA E 112
 None
 0.90A 4p65F-3sdiE:
undetectable
4p65H-3sdiE:
undetectable
4p65K-3sdiE:
undetectable
4p65L-3sdiE:
undetectable		 4p65F-3sdiE:
9.91
4p65H-3sdiE:
9.91
4p65K-3sdiE:
13.95
4p65L-3sdiE:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts9 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		no annotation 5 LEU A  86
LEU A 117
ILE A  17
HIS A  63
LEU A  64
 None
 0.99A 4p65F-3ts9A:
undetectable
4p65H-3ts9A:
undetectable
4p65K-3ts9A:
undetectable
4p65L-3ts9A:
undetectable		 4p65F-3ts9A:
19.75
4p65H-3ts9A:
19.75
4p65K-3ts9A:
6.57
4p65L-3ts9A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vd8 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
INTERFERON-INDUCIBLE
PROTEIN AIM2

(Escherichia
coli;
Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 LEU A 115
ILE A 132
LEU A 139
LEU A 122
ALA A 223
 None
 1.04A 4p65F-3vd8A:
undetectable
4p65H-3vd8A:
undetectable
4p65K-3vd8A:
undetectable
4p65L-3vd8A:
undetectable		 4p65F-3vd8A:
5.77
4p65H-3vd8A:
5.77
4p65K-3vd8A:
5.06
4p65L-3vd8A:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avo BETA-1,4-EXOCELLULAS
E

(Thermobifida
fusca) 		PF01341
(Glyco_hydro_6) 		5 VAL A 217
LEU A 265
HIS A 200
LEU A 201
ALA A 204
 None
 0.78A 4p65F-4avoA:
undetectable
4p65H-4avoA:
undetectable
4p65K-4avoA:
undetectable
4p65L-4avoA:
undetectable		 4p65F-4avoA:
5.56
4p65H-4avoA:
5.56
4p65K-4avoA:
3.96
4p65L-4avoA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA

(Drosophila
melanogaster;
Eptatretus
burgeri) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 VAL R 405
LEU R 402
LEU R 440
LEU R 421
ALA R 451
 None
 1.04A 4p65F-4bv4R:
undetectable
4p65H-4bv4R:
undetectable
4p65K-4bv4R:
undetectable
4p65L-4bv4R:
undetectable		 4p65F-4bv4R:
6.02
4p65H-4bv4R:
6.02
4p65K-4bv4R:
5.31
4p65L-4bv4R:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		5 LEU A 227
VAL A 323
ILE A 321
LEU A 242
ALA A 238
 None
 0.99A 4p65F-4cnkA:
undetectable
4p65H-4cnkA:
undetectable
4p65K-4cnkA:
undetectable
4p65L-4cnkA:
undetectable		 4p65F-4cnkA:
7.78
4p65H-4cnkA:
7.78
4p65K-4cnkA:
5.79
4p65L-4cnkA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd6 ARYLALKYLAMINE
N-ACETYLTRANSFERASE
2

(Aedes aegypti) 		PF00583
(Acetyltransf_1) 		5 VAL A  22
HIS A  25
LEU A  26
ILE A  75
LEU A 151
 None
 0.87A 4p65F-4fd6A:
undetectable
4p65H-4fd6A:
undetectable
4p65K-4fd6A:
undetectable
4p65L-4fd6A:
undetectable		 4p65F-4fd6A:
9.95
4p65H-4fd6A:
9.95
4p65K-4fd6A:
7.21
4p65L-4fd6A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3a CLIP-ASSOCIATING
PROTEIN

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		5 LEU A  54
ILE A  13
LEU A  31
LEU A  35
ALA A  72
 None
 1.06A 4p65F-4g3aA:
undetectable
4p65H-4g3aA:
undetectable
4p65K-4g3aA:
undetectable
4p65L-4g3aA:
undetectable		 4p65F-4g3aA:
9.27
4p65H-4g3aA:
9.27
4p65K-4g3aA:
7.98
4p65L-4g3aA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		5 LEU A 626
LEU A 676
ILE A 557
HIS A 603
LEU A 604
 None
 0.79A 4p65F-4gl2A:
undetectable
4p65H-4gl2A:
undetectable
4p65K-4gl2A:
undetectable
4p65L-4gl2A:
undetectable		 4p65F-4gl2A:
4.67
4p65H-4gl2A:
4.67
4p65K-4gl2A:
3.31
4p65L-4gl2A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb5 ENGINEERED PROTEIN

(synthetic
construct) 		PF12796
(Ank_2) 		5 LEU A 107
VAL A  86
LEU A  74
ILE A 118
ALA A 127
 None
 1.05A 4p65F-4hb5A:
undetectable
4p65H-4hb5A:
undetectable
4p65K-4hb5A:
undetectable
4p65L-4hb5A:
undetectable		 4p65F-4hb5A:
11.11
4p65H-4hb5A:
11.11
4p65K-4hb5A:
7.94
4p65L-4hb5A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrl DESIGNED ANKYRIN
REPEAT PROTEIN 9_29

(synthetic
construct) 		PF12796
(Ank_2) 		5 LEU A 116
VAL A  95
LEU A  83
ILE A 127
ALA A 136
 None
 1.04A 4p65F-4hrlA:
undetectable
4p65H-4hrlA:
undetectable
4p65K-4hrlA:
undetectable
4p65L-4hrlA:
undetectable		 4p65F-4hrlA:
11.73
4p65H-4hrlA:
11.73
4p65K-4hrlA:
5.33
4p65L-4hrlA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5

(Sus scrofa) 		PF00271
(Helicase_C) 		5 LEU A 625
LEU A 673
ILE A 556
HIS A 602
LEU A 603
 None
 0.98A 4p65F-4i1sA:
undetectable
4p65H-4i1sA:
undetectable
4p65K-4i1sA:
undetectable
4p65L-4i1sA:
undetectable		 4p65F-4i1sA:
7.92
4p65H-4i1sA:
7.92
4p65K-4i1sA:
5.13
4p65L-4i1sA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea mays) 		PF00171
(Aldedh) 		5 ILE A 295
CYH A 296
LEU A 423
CYH A 455
ALA A 424
 None
NAD  A 601 ( 2.7A)
NAD  A 601 (-4.4A)
EDO  A 604 ( 4.0A)
None
 1.00A 4p65F-4i8pA:
undetectable
4p65H-4i8pA:
undetectable
4p65K-4i8pA:
undetectable
4p65L-4i8pA:
undetectable		 4p65F-4i8pA:
5.04
4p65H-4i8pA:
5.04
4p65K-4i8pA:
3.47
4p65L-4i8pA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 LEU A 116
ILE A 133
LEU A 140
LEU A 123
ALA A 224
 None
 1.03A 4p65F-4ikmA:
undetectable
4p65H-4ikmA:
undetectable
4p65K-4ikmA:
undetectable
4p65L-4ikmA:
undetectable		 4p65F-4ikmA:
5.85
4p65H-4ikmA:
5.85
4p65K-4ikmA:
2.99
4p65L-4ikmA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je1 PROBABLE THIOL
PEROXIDASE

(Burkholderia
cenocepacia) 		PF08534
(Redoxin) 		5 LEU A  39
VAL A  82
ILE A  80
LEU A 138
ALA A  24
 None
 0.96A 4p65F-4je1A:
undetectable
4p65H-4je1A:
undetectable
4p65K-4je1A:
undetectable
4p65L-4je1A:
undetectable		 4p65F-4je1A:
15.15
4p65H-4je1A:
15.15
4p65K-4je1A:
9.03
4p65L-4je1A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzy CRYPTOCHROME-1

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 LEU A  23
ILE A  67
LEU A 180
HIS A  18
ALA A 178
 None
 0.99A 4p65F-4jzyA:
undetectable
4p65H-4jzyA:
undetectable
4p65K-4jzyA:
undetectable
4p65L-4jzyA:
undetectable		 4p65F-4jzyA:
6.74
4p65H-4jzyA:
6.74
4p65K-4jzyA:
4.71
4p65L-4jzyA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5c LOOP DESIGNED
ANKYRIN REPEAT
PROTEIN NRAN1_G06_C

(Escherichia
coli) 		PF12796
(Ank_2) 		5 LEU A 131
VAL A 110
LEU A  98
ILE A 142
ALA A 151
 None
 1.05A 4p65F-4k5cA:
undetectable
4p65H-4k5cA:
undetectable
4p65K-4k5cA:
undetectable
4p65L-4k5cA:
undetectable		 4p65F-4k5cA:
10.33
4p65H-4k5cA:
10.33
4p65K-4k5cA:
7.14
4p65L-4k5cA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8) 		5 LEU A1120
ILE A1242
LEU A1234
LEU A1055
ALA A1054
 None
 1.05A 4p65F-4kegA:
undetectable
4p65H-4kegA:
undetectable
4p65K-4kegA:
undetectable
4p65L-4kegA:
undetectable		 4p65F-4kegA:
4.98
4p65H-4kegA:
4.98
4p65K-4kegA:
2.59
4p65L-4kegA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lis UDP-GLUCOSE
4-EPIMERASE

(Aspergillus
nidulans) 		PF16363
(GDP_Man_Dehyd) 		5 ILE A 123
LEU A 270
HIS A 263
LEU A 267
ALA A 266
 None
 1.01A 4p65F-4lisA:
undetectable
4p65H-4lisA:
undetectable
4p65K-4lisA:
undetectable
4p65L-4lisA:
undetectable		 4p65F-4lisA:
5.43
4p65H-4lisA:
5.43
4p65K-4lisA:
3.26
4p65L-4lisA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		5 LEU A 249
LEU A 325
LEU A 230
LEU A 254
ALA A 251
 None
 0.86A 4p65F-4nphA:
undetectable
4p65H-4nphA:
undetectable
4p65K-4nphA:
undetectable
4p65L-4nphA:
undetectable		 4p65F-4nphA:
8.98
4p65H-4nphA:
8.98
4p65K-4nphA:
5.99
4p65L-4nphA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A 277
LEU A 252
LEU A 216
LEU A 213
ALA A 212
 None
 1.02A 4p65F-4ppzA:
undetectable
4p65H-4ppzA:
undetectable
4p65K-4ppzA:
undetectable
4p65L-4ppzA:
undetectable		 4p65F-4ppzA:
7.89
4p65H-4ppzA:
7.89
4p65K-4ppzA:
4.92
4p65L-4ppzA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF13685
(Fe-ADH_2) 		5 LEU A 232
VAL A 334
ILE A 253
LEU A 303
ALA A 302
 None
 1.02A 4p65F-4rgqA:
undetectable
4p65H-4rgqA:
undetectable
4p65K-4rgqA:
undetectable
4p65L-4rgqA:
undetectable		 4p65F-4rgqA:
3.80
4p65H-4rgqA:
3.80
4p65K-4rgqA:
5.33
4p65L-4rgqA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rld ASPARTIC PROTEASE
BLA G 2

(Blattella
germanica) 		PF00026
(Asp) 		5 LEU A  53
VAL A  30
LEU A 115
LEU A 107
ALA A  49
 None
 1.03A 4p65F-4rldA:
undetectable
4p65H-4rldA:
undetectable
4p65K-4rldA:
undetectable
4p65L-4rldA:
undetectable		 4p65F-4rldA:
9.95
4p65H-4rldA:
9.95
4p65K-4rldA:
5.36
4p65L-4rldA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase) 		5 VAL A 140
LEU A 114
LEU A 162
LEU A 127
ALA A 130
 None
 0.93A 4p65F-4x3mA:
undetectable
4p65H-4x3mA:
undetectable
4p65K-4x3mA:
undetectable
4p65L-4x3mA:
undetectable		 4p65F-4x3mA:
9.81
4p65H-4x3mA:
9.81
4p65K-4x3mA:
5.56
4p65L-4x3mA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xai MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TAILLESS
ORTHOLOG

(Escherichia
coli;
Tribolium
castaneum) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		5 LEU A 117
ILE A 134
LEU A 141
LEU A 124
ALA A 225
 None
 1.05A 4p65F-4xaiA:
undetectable
4p65H-4xaiA:
undetectable
4p65K-4xaiA:
undetectable
4p65L-4xaiA:
undetectable		 4p65F-4xaiA:
4.06
4p65H-4xaiA:
4.06
4p65K-4xaiA:
3.23
4p65L-4xaiA:
4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 LEU A 635
VAL A 776
LEU A 780
HIS A 817
ALA A 815
 None
 1.06A 4p65F-4yswA:
undetectable
4p65H-4yswA:
undetectable
4p65K-4yswA:
undetectable
4p65L-4yswA:
undetectable		 4p65F-4yswA:
2.17
4p65H-4yswA:
2.17
4p65K-4yswA:
1.48
4p65L-4yswA:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		5 LEU A  51
VAL A  30
LEU A  18
ILE A  62
ALA A  71
 None
 1.03A 4p65F-5aqaA:
undetectable
4p65H-5aqaA:
undetectable
4p65K-5aqaA:
undetectable
4p65L-5aqaA:
undetectable		 4p65F-5aqaA:
5.76
4p65H-5aqaA:
5.76
4p65K-5aqaA:
3.23
4p65L-5aqaA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5byk SULFOTRANSFERASE

(Schistosoma
mansoni) 		no annotation 6 VAL A  10
LEU A 214
ILE A  87
CYH A  35
LEU A  23
ALA A  26
 None
 1.48A 4p65F-5bykA:
undetectable
4p65H-5bykA:
undetectable
4p65K-5bykA:
undetectable
4p65L-5bykA:
undetectable		 4p65F-5bykA:
8.37
4p65H-5bykA:
8.37
4p65K-5bykA:
5.99
4p65L-5bykA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbn MBP3-16,IMMUNOGLOBUL
IN G-BINDING PROTEIN
A

(Staphylococcus
aureus;
synthetic
construct) 		PF02216
(B)
PF12796
(Ank_2) 		6 LEU A  84
VAL A  63
LEU A  51
ILE A  95
LEU A 100
ALA A 104
 None
 1.30A 4p65F-5cbnA:
undetectable
4p65H-5cbnA:
undetectable
4p65K-5cbnA:
undetectable
4p65L-5cbnA:
undetectable		 4p65F-5cbnA:
10.91
4p65H-5cbnA:
10.91
4p65K-5cbnA:
12.50
4p65L-5cbnA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eil TRI-05

(synthetic
construct) 		PF12796
(Ank_2) 		5 LEU A 106
VAL A  85
LEU A  73
ILE A 117
ALA A 126
 None
 1.02A 4p65F-5eilA:
undetectable
4p65H-5eilA:
undetectable
4p65K-5eilA:
undetectable
4p65L-5eilA:
undetectable		 4p65F-5eilA:
11.45
4p65H-5eilA:
11.45
4p65K-5eilA:
6.94
4p65L-5eilA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez7 FLAVOENZYME PA4991

(Pseudomonas
aeruginosa) 		PF01266
(DAO) 		5 LEU A 203
LEU A  10
ILE A 177
LEU A 216
LEU A 186
 None
 1.02A 4p65F-5ez7A:
undetectable
4p65H-5ez7A:
undetectable
4p65K-5ez7A:
undetectable
4p65L-5ez7A:
undetectable		 4p65F-5ez7A:
6.09
4p65H-5ez7A:
6.09
4p65K-5ez7A:
3.71
4p65L-5ez7A:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fo5 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR METR

(Escherichia
coli) 		PF00126
(HTH_1) 		5 LEU A  33
LEU A  40
LEU A  13
HIS A   6
LEU A  10
 None
 0.93A 4p65F-5fo5A:
undetectable
4p65H-5fo5A:
undetectable
4p65K-5fo5A:
undetectable
4p65L-5fo5A:
undetectable		 4p65F-5fo5A:
16.85
4p65H-5fo5A:
16.85
4p65K-5fo5A:
13.10
4p65L-5fo5A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5glj TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 13

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A1164
VAL A1126
ILE A1123
LEU A1173
LEU A1096
 None
CL  A1201 (-4.7A)
None
None
None
 0.95A 4p65F-5gljA:
undetectable
4p65H-5gljA:
undetectable
4p65K-5gljA:
undetectable
4p65L-5gljA:
undetectable		 4p65F-5gljA:
14.44
4p65H-5gljA:
14.44
4p65K-5gljA:
10.34
4p65L-5gljA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 LEU A 116
ILE A 133
LEU A 140
LEU A 123
ALA A 224
 None
 1.04A 4p65F-5h7nA:
undetectable
4p65H-5h7nA:
undetectable
4p65K-5h7nA:
undetectable
4p65L-5h7nA:
undetectable		 4p65F-5h7nA:
5.88
4p65H-5h7nA:
5.88
4p65K-5h7nA:
4.35
4p65L-5h7nA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 VAL A 557
LEU A 554
LEU A 592
LEU A 573
ALA A 603
 None
 1.04A 4p65F-5ijbA:
undetectable
4p65H-5ijbA:
undetectable
4p65K-5ijbA:
undetectable
4p65L-5ijbA:
undetectable		 4p65F-5ijbA:
4.12
4p65H-5ijbA:
4.12
4p65K-5ijbA:
3.84
4p65L-5ijbA:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jab BILIVERDIN REDUCTASE
RV2074

(Mycobacterium
tuberculosis) 		PF01243
(Putative_PNPOx) 		6 LEU A  82
VAL A   4
ILE A 124
LEU A  18
LEU A  15
ALA A  14
 None
 1.49A 4p65F-5jabA:
undetectable
4p65H-5jabA:
undetectable
4p65K-5jabA:
undetectable
4p65L-5jabA:
undetectable		 4p65F-5jabA:
13.64
4p65H-5jabA:
13.64
4p65K-5jabA:
14.86
4p65L-5jabA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		5 LEU A 306
LEU A 324
ILE A 236
HIS A 283
LEU A 284
 None
 0.97A 4p65F-5jbgA:
undetectable
4p65H-5jbgA:
undetectable
4p65K-5jbgA:
undetectable
4p65L-5jbgA:
undetectable		 4p65F-5jbgA:
4.00
4p65H-5jbgA:
4.00
4p65K-5jbgA:
2.84
4p65L-5jbgA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwd ANKYRIN
REPEAT-CONTAINING
PROTEIN

(Metallosphaera
yellowstonensis) 		PF12796
(Ank_2) 		5 LEU A 106
VAL A  85
LEU A  73
ILE A 117
ALA A 126
 None
 1.02A 4p65F-5kwdA:
undetectable
4p65H-5kwdA:
undetectable
4p65K-5kwdA:
undetectable
4p65L-5kwdA:
undetectable		 4p65F-5kwdA:
11.81
4p65H-5kwdA:
11.81
4p65K-5kwdA:
7.64
4p65L-5kwdA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5le4 DD_D12_11_D12

(synthetic
construct) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A 117
VAL A  96
LEU A  84
ILE A 128
ALA A 137
 None
 1.03A 4p65F-5le4A:
undetectable
4p65H-5le4A:
undetectable
4p65K-5le4A:
undetectable
4p65L-5le4A:
undetectable		 4p65F-5le4A:
10.50
4p65H-5le4A:
10.50
4p65K-5le4A:
6.03
4p65L-5le4A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5le9 DD_OFF7_09_3G124

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU A 272
VAL A 251
LEU A 239
ILE A 283
ALA A 292
 None
 1.05A 4p65F-5le9A:
undetectable
4p65H-5le9A:
undetectable
4p65K-5le9A:
undetectable
4p65L-5le9A:
undetectable		 4p65F-5le9A:
7.72
4p65H-5le9A:
7.72
4p65K-5le9A:
6.17
4p65L-5le9A:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5leb DDD_D12_06_D12_06_D1
2

(synthetic
construct) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A 117
VAL A  96
LEU A  84
ILE A 128
ALA A 137
 None
 1.03A 4p65F-5lebA:
undetectable
4p65H-5lebA:
undetectable
4p65K-5lebA:
undetectable
4p65L-5lebA:
undetectable		 4p65F-5lebA:
6.56
4p65H-5lebA:
6.56
4p65K-5lebA:
4.34
4p65L-5lebA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5leb DDD_D12_06_D12_06_D1
2

(synthetic
construct) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A 269
VAL A 248
LEU A 236
ILE A 280
ALA A 289
 None
 1.01A 4p65F-5lebA:
undetectable
4p65H-5lebA:
undetectable
4p65K-5lebA:
undetectable
4p65L-5lebA:
undetectable		 4p65F-5lebA:
6.56
4p65H-5lebA:
6.56
4p65K-5lebA:
4.34
4p65L-5lebA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw2 DARPIN_5M3_D12

(synthetic
construct) 		PF12796
(Ank_2) 		5 LEU A 117
VAL A  96
LEU A  84
ILE A 128
ALA A 137
 None
 1.02A 4p65F-5lw2A:
undetectable
4p65H-5lw2A:
undetectable
4p65K-5lw2A:
undetectable
4p65L-5lw2A:
undetectable		 4p65F-5lw2A:
17.27
4p65H-5lw2A:
17.27
4p65K-5lw2A:
9.17
4p65L-5lw2A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ma6 3G124NC

(synthetic
construct) 		no annotation 5 LEU B  51
VAL B  30
LEU B  18
ILE B  62
ALA B  71
 None
None
None
PO4  B 201 (-4.4A)
None
 1.05A 4p65F-5ma6B:
undetectable
4p65H-5ma6B:
undetectable
4p65K-5ma6B:
undetectable
4p65L-5ma6B:
undetectable		 4p65F-5ma6B:
undetectable
4p65H-5ma6B:
undetectable
4p65K-5ma6B:
undetectable
4p65L-5ma6B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mbm DARPIN 8H6

(synthetic
construct) 		no annotation 6 LEU C  83
VAL C  62
LEU C  51
ILE C  94
LEU C  99
ALA C 103
 None
 1.33A 4p65F-5mbmC:
undetectable
4p65H-5mbmC:
undetectable
4p65K-5mbmC:
undetectable
4p65L-5mbmC:
undetectable		 4p65F-5mbmC:
undetectable
4p65H-5mbmC:
undetectable
4p65K-5mbmC:
undetectable
4p65L-5mbmC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyj DARPIN D4B

(synthetic
construct) 		no annotation 5 LEU A  51
VAL A  30
LEU A  18
ILE A  62
ALA A  71
 None
 1.05A 4p65F-5oyjA:
undetectable
4p65H-5oyjA:
undetectable
4p65K-5oyjA:
undetectable
4p65L-5oyjA:
undetectable		 4p65F-5oyjA:
undetectable
4p65H-5oyjA:
undetectable
4p65K-5oyjA:
undetectable
4p65L-5oyjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4z REPRESSOR OF RNA
POLYMERASE III
TRANSCRIPTION

(Citrus sinensis) 		PF09174
(Maf1) 		5 LEU A   9
LEU A  16
LEU A 145
LEU A 141
ALA A 144
 None
 1.05A 4p65F-5u4zA:
undetectable
4p65H-5u4zA:
undetectable
4p65K-5u4zA:
undetectable
4p65L-5u4zA:
undetectable		 4p65F-5u4zA:
7.94
4p65H-5u4zA:
7.94
4p65K-5u4zA:
5.70
4p65L-5u4zA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH

(Brachybacterium
faecium) 		PF01636
(APH) 		5 LEU A 243
VAL A 127
LEU A 123
LEU A 257
HIS A 230
 None
 0.91A 4p65F-5uxbA:
undetectable
4p65H-5uxbA:
undetectable
4p65K-5uxbA:
undetectable
4p65L-5uxbA:
undetectable		 4p65F-5uxbA:
8.64
4p65H-5uxbA:
8.64
4p65K-5uxbA:
8.55
4p65L-5uxbA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA

(Acinetobacter
baumannii;
Escherichia
coli) 		no annotation 5 LEU A 115
ILE A 132
LEU A 139
LEU A 122
ALA A 223
 None
 0.95A 4p65F-5vawA:
undetectable
4p65H-5vawA:
undetectable
4p65K-5vawA:
undetectable
4p65L-5vawA:
undetectable		 4p65F-5vawA:
undetectable
4p65H-5vawA:
undetectable
4p65K-5vawA:
undetectable
4p65L-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrb TRANSKETOLASE

(Neisseria
gonorrhoeae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 602
VAL A 655
LEU A 659
ILE A 605
ALA A 547
 None
 1.02A 4p65F-5vrbA:
undetectable
4p65H-5vrbA:
undetectable
4p65K-5vrbA:
undetectable
4p65L-5vrbA:
undetectable		 4p65F-5vrbA:
4.40
4p65H-5vrbA:
4.40
4p65K-5vrbA:
3.09
4p65L-5vrbA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjh PERIOSTIN

(Homo sapiens) 		no annotation 5 LEU A 271
LEU A 247
HIS A 359
LEU A 360
ALA A 273
 None
MG  A 723 ( 4.7A)
None
None
None
 0.90A 4p65F-5yjhA:
undetectable
4p65H-5yjhA:
undetectable
4p65K-5yjhA:
undetectable
4p65L-5yjhA:
undetectable		 4p65F-5yjhA:
undetectable
4p65H-5yjhA:
undetectable
4p65K-5yjhA:
undetectable
4p65L-5yjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE

(Bacillus
alcalophilus) 		no annotation 5 LEU A 135
CYH A  84
ILE A  82
LEU A 109
ALA A 112
 None
 0.85A 4p65F-5yo8A:
undetectable
4p65H-5yo8A:
undetectable
4p65K-5yo8A:
undetectable
4p65L-5yo8A:
undetectable		 4p65F-5yo8A:
undetectable
4p65H-5yo8A:
undetectable
4p65K-5yo8A:
undetectable
4p65L-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbn DARPIN

(Escherichia
coli) 		no annotation 5 LEU P  51
VAL P  30
LEU P  18
ILE P  62
ALA P  71
 None
 1.01A 4p65F-6bbnP:
undetectable
4p65H-6bbnP:
undetectable
4p65K-6bbnP:
undetectable
4p65L-6bbnP:
undetectable		 4p65F-6bbnP:
undetectable
4p65H-6bbnP:
undetectable
4p65K-6bbnP:
undetectable
4p65L-6bbnP:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5e DD_D12_10_47

(synthetic
construct) 		no annotation 5 LEU A  51
VAL A  30
LEU A  18
ILE A  62
ALA A  71
 None
 1.00A 4p65F-6f5eA:
undetectable
4p65H-6f5eA:
undetectable
4p65K-6f5eA:
undetectable
4p65L-6f5eA:
undetectable		 4p65F-6f5eA:
undetectable
4p65H-6f5eA:
undetectable
4p65K-6f5eA:
undetectable
4p65L-6f5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5e DD_D12_10_47

(synthetic
construct) 		no annotation 5 LEU A  84
VAL A  63
LEU A  51
ILE A  95
ALA A 104
 None
 1.03A 4p65F-6f5eA:
undetectable
4p65H-6f5eA:
undetectable
4p65K-6f5eA:
undetectable
4p65L-6f5eA:
undetectable		 4p65F-6f5eA:
undetectable
4p65H-6f5eA:
undetectable
4p65K-6f5eA:
undetectable
4p65L-6f5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5e DD_D12_10_47

(synthetic
construct) 		no annotation 5 LEU A 273
VAL A 252
LEU A 240
ILE A 284
ALA A 293
 None
 1.02A 4p65F-6f5eA:
undetectable
4p65H-6f5eA:
undetectable
4p65K-6f5eA:
undetectable
4p65L-6f5eA:
undetectable		 4p65F-6f5eA:
undetectable
4p65H-6f5eA:
undetectable
4p65K-6f5eA:
undetectable
4p65L-6f5eA:
undetectable