SIMILAR PATTERNS OF AMINO ACIDS FOR 4P65_G_IPHG101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6f PLACENTAL LACTOGEN

(Ovis aries) 		PF00103
(Hormone_1) 		5 LEU A 157
LEU A 172
HIS A  98
LEU A  97
ALA A 100
 None
 1.05A 4p65B-1f6fA:
undetectable
4p65D-1f6fA:
undetectable
4p65G-1f6fA:
undetectable
4p65H-1f6fA:
undetectable		 4p65B-1f6fA:
12.36
4p65D-1f6fA:
12.36
4p65G-1f6fA:
10.42
4p65H-1f6fA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fy2 ASPARTYL DIPEPTIDASE

(Salmonella
enterica) 		PF03575
(Peptidase_S51) 		5 LEU A  94
VAL A  85
LEU A 103
LEU A 147
ALA A 146
 None
 1.15A 4p65B-1fy2A:
undetectable
4p65D-1fy2A:
undetectable
4p65G-1fy2A:
undetectable
4p65H-1fy2A:
undetectable		 4p65B-1fy2A:
8.10
4p65D-1fy2A:
8.10
4p65G-1fy2A:
8.59
4p65H-1fy2A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 VAL A 246
CYH A 345
LEU A 381
LEU A 373
ALA A 377
 None
 1.00A 4p65B-1gzkA:
undetectable
4p65D-1gzkA:
undetectable
4p65G-1gzkA:
undetectable
4p65H-1gzkA:
undetectable		 4p65B-1gzkA:
10.13
4p65D-1gzkA:
10.13
4p65G-1gzkA:
7.94
4p65H-1gzkA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j33 COBT

(Thermus
thermophilus) 		PF02277
(DBI_PRT) 		5 LEU A 249
HIS A 283
LEU A 290
LEU A 259
ALA A 258
 None
 1.05A 4p65B-1j33A:
undetectable
4p65D-1j33A:
undetectable
4p65G-1j33A:
undetectable
4p65H-1j33A:
undetectable		 4p65B-1j33A:
5.52
4p65D-1j33A:
5.52
4p65G-1j33A:
5.83
4p65H-1j33A:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 791
LEU A 855
CYH A 698
LEU A 702
ALA A 705
 None
 1.04A 4p65B-1lufA:
undetectable
4p65D-1lufA:
undetectable
4p65G-1lufA:
undetectable
4p65H-1lufA:
undetectable		 4p65B-1lufA:
6.34
4p65D-1lufA:
6.34
4p65G-1lufA:
4.47
4p65H-1lufA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n31 L-CYSTEINE/CYSTINE
LYASE C-DES

(Synechocystis
sp. PCC 6714) 		PF00266
(Aminotran_5) 		5 LEU A 174
VAL A 194
CYH A 183
LEU A 150
ALA A 146
 None
 1.12A 4p65B-1n31A:
undetectable
4p65D-1n31A:
undetectable
4p65G-1n31A:
undetectable
4p65H-1n31A:
undetectable		 4p65B-1n31A:
9.13
4p65D-1n31A:
9.13
4p65G-1n31A:
3.95
4p65H-1n31A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU E 187
VAL E 160
LEU E 148
LEU E 205
ALA E 207
 None
 1.03A 4p65B-1nfiE:
undetectable
4p65D-1nfiE:
undetectable
4p65G-1nfiE:
undetectable
4p65H-1nfiE:
undetectable		 4p65B-1nfiE:
11.76
4p65D-1nfiE:
11.76
4p65G-1nfiE:
7.77
4p65H-1nfiE:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE

(Mycobacterium
tuberculosis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 LEU A  67
LEU A  60
LEU A 100
LEU A  93
ALA A  95
 None
 1.09A 4p65B-1qpoA:
undetectable
4p65D-1qpoA:
undetectable
4p65G-1qpoA:
undetectable
4p65H-1qpoA:
undetectable		 4p65B-1qpoA:
5.75
4p65D-1qpoA:
5.75
4p65G-1qpoA:
4.58
4p65H-1qpoA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 XYLANASE INHIBITOR
PROTEIN I

(Triticum
aestivum) 		PF00704
(Glyco_hydro_18) 		5 VAL A 123
LEU A 143
LEU A  86
LEU A  95
ALA A  92
 None
 1.13A 4p65B-1ta3A:
undetectable
4p65D-1ta3A:
undetectable
4p65G-1ta3A:
undetectable
4p65H-1ta3A:
undetectable		 4p65B-1ta3A:
10.73
4p65D-1ta3A:
10.73
4p65G-1ta3A:
8.38
4p65H-1ta3A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttw SECRETION CHAPERONE

(Yersinia pestis) 		PF05932
(CesT) 		5 LEU A  57
CYH A  81
LEU A  91
LEU A 119
ALA A  54
 None
 0.96A 4p65B-1ttwA:
undetectable
4p65D-1ttwA:
undetectable
4p65G-1ttwA:
undetectable
4p65H-1ttwA:
undetectable		 4p65B-1ttwA:
15.05
4p65D-1ttwA:
15.05
4p65G-1ttwA:
9.35
4p65H-1ttwA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlj INTERFERON
STIMULATED GENE
20KDA

(Homo sapiens) 		PF00929
(RNase_T) 		5 LEU A  91
CYH A  28
LEU A  25
LEU A  98
ALA A  97
 None
 1.14A 4p65B-1wljA:
undetectable
4p65D-1wljA:
undetectable
4p65G-1wljA:
undetectable
4p65H-1wljA:
undetectable		 4p65B-1wljA:
11.39
4p65D-1wljA:
11.39
4p65G-1wljA:
7.84
4p65H-1wljA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woi AGMATINASE

(Deinococcus
radiodurans) 		PF00491
(Arginase) 		5 LEU A 258
VAL A 214
LEU A 211
LEU A 142
LEU A 249
 None
 1.09A 4p65B-1woiA:
undetectable
4p65D-1woiA:
undetectable
4p65G-1woiA:
undetectable
4p65H-1woiA:
undetectable		 4p65B-1woiA:
8.37
4p65D-1woiA:
8.37
4p65G-1woiA:
4.50
4p65H-1woiA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE

(Homo sapiens) 		PF00103
(Hormone_1) 		5 LEU A  93
LEU A  87
LEU A  23
HIS A 112
LEU A 113
 None
 1.05A 4p65B-1z7cA:
undetectable
4p65D-1z7cA:
undetectable
4p65G-1z7cA:
undetectable
4p65H-1z7cA:
undetectable		 4p65B-1z7cA:
14.74
4p65D-1z7cA:
14.74
4p65G-1z7cA:
8.20
4p65H-1z7cA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aiz OUTER MEMBRANE
PROTEIN P6

(Haemophilus
influenzae) 		PF00691
(OmpA) 		5 VAL P  66
LEU P 132
HIS P  52
LEU P  49
ALA P  53
 None
 1.04A 4p65B-2aizP:
undetectable
4p65D-2aizP:
undetectable
4p65G-2aizP:
undetectable
4p65H-2aizP:
undetectable		 4p65B-2aizP:
12.69
4p65D-2aizP:
12.69
4p65G-2aizP:
16.67
4p65H-2aizP:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		PF12937
(F-box-like) 		5 LEU B2235
VAL B2183
LEU B2213
CYH B2205
LEU B2202
 None
 1.11A 4p65B-2assB:
undetectable
4p65D-2assB:
undetectable
4p65G-2assB:
undetectable
4p65H-2assB:
undetectable		 4p65B-2assB:
7.37
4p65D-2assB:
7.37
4p65G-2assB:
7.11
4p65H-2assB:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8e CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 LEU A 586
LEU A 561
LEU A 429
LEU A 655
ALA A 554
 None
 1.16A 4p65B-2b8eA:
undetectable
4p65D-2b8eA:
undetectable
4p65G-2b8eA:
undetectable
4p65H-2b8eA:
undetectable		 4p65B-2b8eA:
8.13
4p65D-2b8eA:
8.13
4p65G-2b8eA:
8.70
4p65H-2b8eA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8e CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 LEU A 586
VAL A 421
LEU A 561
LEU A 429
ALA A 554
 None
 1.00A 4p65B-2b8eA:
undetectable
4p65D-2b8eA:
undetectable
4p65G-2b8eA:
undetectable
4p65H-2b8eA:
undetectable		 4p65B-2b8eA:
8.13
4p65D-2b8eA:
8.13
4p65G-2b8eA:
8.70
4p65H-2b8eA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		5 VAL A 162
LEU A 137
LEU A 233
LEU A 151
ALA A 154
 None
 0.82A 4p65B-2dulA:
undetectable
4p65D-2dulA:
undetectable
4p65G-2dulA:
undetectable
4p65H-2dulA:
undetectable		 4p65B-2dulA:
6.12
4p65D-2dulA:
6.12
4p65G-2dulA:
4.18
4p65H-2dulA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 LEU A  86
VAL A  78
LEU A 292
LEU A 257
LEU A   5
 None
 1.06A 4p65B-2ffhA:
undetectable
4p65D-2ffhA:
undetectable
4p65G-2ffhA:
undetectable
4p65H-2ffhA:
undetectable		 4p65B-2ffhA:
6.36
4p65D-2ffhA:
6.36
4p65G-2ffhA:
4.72
4p65H-2ffhA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8l 287AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01937
(DUF89) 		5 LEU A 133
LEU A 167
CYH A 280
LEU A 259
ALA A 104
 None
 1.15A 4p65B-2g8lA:
undetectable
4p65D-2g8lA:
undetectable
4p65G-2g8lA:
undetectable
4p65H-2g8lA:
undetectable		 4p65B-2g8lA:
7.17
4p65D-2g8lA:
7.17
4p65G-2g8lA:
4.42
4p65H-2g8lA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnw NON-SYMBIOTIC
HEMOGLOBIN 1

(Oryza sativa) 		PF00042
(Globin) 		5 LEU A  88
LEU A 101
HIS A 152
LEU A 153
ALA A 156
 None
None
None
HEM  A 166 ( 4.7A)
None
 1.13A 4p65B-2gnwA:
undetectable
4p65D-2gnwA:
undetectable
4p65G-2gnwA:
undetectable
4p65H-2gnwA:
undetectable		 4p65B-2gnwA:
9.70
4p65D-2gnwA:
9.70
4p65G-2gnwA:
5.45
4p65H-2gnwA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU A  86
VAL A  78
LEU A 292
LEU A 257
LEU A   5
 None
 1.09A 4p65B-2ng1A:
undetectable
4p65D-2ng1A:
undetectable
4p65G-2ng1A:
undetectable
4p65H-2ng1A:
undetectable		 4p65B-2ng1A:
7.64
4p65D-2ng1A:
7.64
4p65G-2ng1A:
5.15
4p65H-2ng1A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0f RNA URIDYLYL
TRANSFERASE

(Trypanosoma
brucei) 		PF03828
(PAP_assoc) 		5 LEU A 329
LEU A 177
HIS A 320
LEU A 321
ALA A 324
 None
 1.01A 4p65B-2q0fA:
undetectable
4p65D-2q0fA:
undetectable
4p65G-2q0fA:
undetectable
4p65H-2q0fA:
undetectable		 4p65B-2q0fA:
6.34
4p65D-2q0fA:
6.34
4p65G-2q0fA:
5.48
4p65H-2q0fA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0f RNA URIDYLYL
TRANSFERASE

(Trypanosoma
brucei) 		PF03828
(PAP_assoc) 		5 LEU A 329
LEU A 177
LEU A 245
HIS A 320
ALA A 324
 None
 1.08A 4p65B-2q0fA:
undetectable
4p65D-2q0fA:
undetectable
4p65G-2q0fA:
undetectable
4p65H-2q0fA:
undetectable		 4p65B-2q0fA:
6.34
4p65D-2q0fA:
6.34
4p65G-2q0fA:
5.48
4p65H-2q0fA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qg1 MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A1766
VAL A1775
LEU A1738
LEU A1736
ALA A1760
 None
 1.14A 4p65B-2qg1A:
undetectable
4p65D-2qg1A:
undetectable
4p65G-2qg1A:
undetectable
4p65H-2qg1A:
undetectable		 4p65B-2qg1A:
21.31
4p65D-2qg1A:
21.31
4p65G-2qg1A:
10.23
4p65H-2qg1A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ucz UBIQUITIN
CONJUGATING ENZYME

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		5 LEU A  16
LEU A   9
LEU A 120
LEU A  58
ALA A  26
 None
 1.03A 4p65B-2uczA:
undetectable
4p65D-2uczA:
undetectable
4p65G-2uczA:
undetectable
4p65H-2uczA:
undetectable		 4p65B-2uczA:
11.45
4p65D-2uczA:
11.45
4p65G-2uczA:
11.30
4p65H-2uczA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		5 LEU A 115
CYH A 283
LEU A 279
LEU A 110
ALA A 107
 None
 1.14A 4p65B-2vg2A:
undetectable
4p65D-2vg2A:
undetectable
4p65G-2vg2A:
undetectable
4p65H-2vg2A:
undetectable		 4p65B-2vg2A:
9.33
4p65D-2vg2A:
9.33
4p65G-2vg2A:
10.00
4p65H-2vg2A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 LEU I 586
LEU I 561
LEU I 429
LEU I 655
ALA I 554
 None
 1.16A 4p65B-2voyI:
undetectable
4p65D-2voyI:
undetectable
4p65G-2voyI:
undetectable
4p65H-2voyI:
undetectable		 4p65B-2voyI:
15.15
4p65D-2voyI:
15.15
4p65G-2voyI:
9.89
4p65H-2voyI:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 LEU I 586
VAL I 421
LEU I 561
LEU I 429
ALA I 554
 None
 1.00A 4p65B-2voyI:
undetectable
4p65D-2voyI:
undetectable
4p65G-2voyI:
undetectable
4p65H-2voyI:
undetectable		 4p65B-2voyI:
15.15
4p65D-2voyI:
15.15
4p65G-2voyI:
9.89
4p65H-2voyI:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmm CHROMOSOME PARTITION
PROTEIN MUKB

(Escherichia
coli) 		PF16330
(MukB_hinge) 		5 LEU A 677
VAL A 714
LEU A 734
HIS A 723
LEU A 724
 None
 1.16A 4p65B-2wmmA:
undetectable
4p65D-2wmmA:
undetectable
4p65G-2wmmA:
undetectable
4p65H-2wmmA:
undetectable		 4p65B-2wmmA:
11.18
4p65D-2wmmA:
11.18
4p65G-2wmmA:
9.02
4p65H-2wmmA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x32 CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF04264
(YceI) 		5 LEU A  47
VAL A 164
LEU A  12
LEU A 104
ALA A  74
 None
OTP  A1174 ( 4.6A)
None
OTP  A1174 ( 4.5A)
OTP  A1174 ( 4.9A)
 1.15A 4p65B-2x32A:
undetectable
4p65D-2x32A:
undetectable
4p65G-2x32A:
undetectable
4p65H-2x32A:
undetectable		 4p65B-2x32A:
11.59
4p65D-2x32A:
11.59
4p65G-2x32A:
11.67
4p65H-2x32A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8u SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
wittichii) 		PF00155
(Aminotran_1_2) 		5 VAL A 332
LEU A 320
LEU A 373
HIS A 310
LEU A 309
 None
 1.01A 4p65B-2x8uA:
undetectable
4p65D-2x8uA:
undetectable
4p65G-2x8uA:
undetectable
4p65H-2x8uA:
undetectable		 4p65B-2x8uA:
6.76
4p65D-2x8uA:
6.76
4p65G-2x8uA:
12.04
4p65H-2x8uA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 LEU A   4
VAL A  91
LEU A  81
LEU A  69
ALA A  35
 None
 1.12A 4p65B-2yzmA:
undetectable
4p65D-2yzmA:
undetectable
4p65G-2yzmA:
undetectable
4p65H-2yzmA:
undetectable		 4p65B-2yzmA:
7.21
4p65D-2yzmA:
7.21
4p65G-2yzmA:
4.38
4p65H-2yzmA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0q RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 3

(Mus musculus) 		PF00621
(RhoGEF) 		5 LEU A  95
LEU A 160
HIS A 176
LEU A 177
ALA A 180
 None
 1.00A 4p65B-2z0qA:
undetectable
4p65D-2z0qA:
undetectable
4p65G-2z0qA:
undetectable
4p65H-2z0qA:
undetectable		 4p65B-2z0qA:
7.25
4p65D-2z0qA:
7.25
4p65G-2z0qA:
4.85
4p65H-2z0qA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrobaculum
aerophilum) 		PF07995
(GSDH) 		5 LEU A  95
LEU A  70
LEU A  97
LEU A  54
ALA A  52
 None
 1.07A 4p65B-3a9gA:
undetectable
4p65D-3a9gA:
undetectable
4p65G-3a9gA:
undetectable
4p65H-3a9gA:
undetectable		 4p65B-3a9gA:
5.95
4p65D-3a9gA:
5.95
4p65G-3a9gA:
4.12
4p65H-3a9gA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11

(Methanocaldococcus
jannaschii) 		PF00149
(Metallophos) 		5 LEU A 100
VAL A  44
LEU A  71
LEU A  50
ALA A  64
 None
 1.06A 4p65B-3auzA:
undetectable
4p65D-3auzA:
undetectable
4p65G-3auzA:
undetectable
4p65H-3auzA:
undetectable		 4p65B-3auzA:
7.07
4p65D-3auzA:
7.07
4p65G-3auzA:
4.82
4p65H-3auzA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0h NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 VAL A 227
LEU A 244
LEU A 221
CYH A 289
LEU A 293
 None
 1.01A 4p65B-3b0hA:
undetectable
4p65D-3b0hA:
undetectable
4p65G-3b0hA:
undetectable
4p65H-3b0hA:
undetectable		 4p65B-3b0hA:
4.94
4p65D-3b0hA:
4.94
4p65G-3b0hA:
3.98
4p65H-3b0hA:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cit SENSOR HISTIDINE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 LEU A 148
LEU A 155
LEU A 131
LEU A  51
ALA A  54
 None
 0.88A 4p65B-3citA:
undetectable
4p65D-3citA:
undetectable
4p65G-3citA:
undetectable
4p65H-3citA:
undetectable		 4p65B-3citA:
14.41
4p65D-3citA:
14.41
4p65G-3citA:
11.90
4p65H-3citA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A  32
LEU A 206
CYH A 214
LEU A 212
ALA A  19
 None
 1.08A 4p65B-3e7wA:
undetectable
4p65D-3e7wA:
undetectable
4p65G-3e7wA:
undetectable
4p65H-3e7wA:
undetectable		 4p65B-3e7wA:
7.97
4p65D-3e7wA:
7.97
4p65G-3e7wA:
3.91
4p65H-3e7wA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A

(Homo sapiens) 		PF00620
(RhoGAP) 		5 LEU A 159
LEU A 204
HIS A 138
LEU A 142
ALA A 140
 None
 1.15A 4p65B-3eapA:
undetectable
4p65D-3eapA:
undetectable
4p65G-3eapA:
undetectable
4p65H-3eapA:
undetectable		 4p65B-3eapA:
7.84
4p65D-3eapA:
7.84
4p65G-3eapA:
8.57
4p65H-3eapA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnr ARGINYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00750
(tRNA-synt_1d)
PF05746
(DALR_1) 		5 LEU A 470
LEU A 477
LEU A 136
LEU A 461
ALA A 464
 None
 1.16A 4p65B-3fnrA:
undetectable
4p65D-3fnrA:
undetectable
4p65G-3fnrA:
undetectable
4p65H-3fnrA:
undetectable		 4p65B-3fnrA:
4.83
4p65D-3fnrA:
4.83
4p65G-3fnrA:
5.64
4p65H-3fnrA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		5 LEU A 323
VAL A 364
LEU A 390
LEU A 337
ALA A 333
 None
 1.06A 4p65B-3g8mA:
undetectable
4p65D-3g8mA:
undetectable
4p65G-3g8mA:
undetectable
4p65H-3g8mA:
undetectable		 4p65B-3g8mA:
6.49
4p65D-3g8mA:
6.49
4p65G-3g8mA:
4.90
4p65H-3g8mA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		PF11715
(Nup160) 		5 LEU A 680
VAL A 709
LEU A 616
LEU A 675
ALA A 676
 None
 1.07A 4p65B-3h7nA:
undetectable
4p65D-3h7nA:
undetectable
4p65G-3h7nA:
undetectable
4p65H-3h7nA:
undetectable		 4p65B-3h7nA:
4.71
4p65D-3h7nA:
4.71
4p65G-3h7nA:
2.59
4p65H-3h7nA:
4.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhr HUMAN GROWTH HORMONE

(Homo sapiens) 		PF00103
(Hormone_1) 		5 LEU A 177
LEU A 117
HIS A  21
LEU A  20
ALA A  17
 None
 1.06A 4p65B-3hhrA:
undetectable
4p65D-3hhrA:
undetectable
4p65G-3hhrA:
undetectable
4p65H-3hhrA:
undetectable		 4p65B-3hhrA:
10.29
4p65D-3hhrA:
10.29
4p65G-3hhrA:
7.89
4p65H-3hhrA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		5 LEU A 407
LEU A 463
LEU A 491
LEU A 302
ALA A 305
 None
 1.14A 4p65B-3mdyA:
undetectable
4p65D-3mdyA:
undetectable
4p65G-3mdyA:
undetectable
4p65H-3mdyA:
undetectable		 4p65B-3mdyA:
5.97
4p65D-3mdyA:
5.97
4p65G-3mdyA:
5.65
4p65H-3mdyA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no3 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Parabacteroides
distasonis) 		PF03009
(GDPD) 		5 LEU A  47
VAL A  62
LEU A 120
LEU A 109
ALA A 112
 None
 1.14A 4p65B-3no3A:
undetectable
4p65D-3no3A:
undetectable
4p65G-3no3A:
undetectable
4p65H-3no3A:
undetectable		 4p65B-3no3A:
7.98
4p65D-3no3A:
7.98
4p65G-3no3A:
8.18
4p65H-3no3A:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		5 LEU B 431
VAL B 423
LEU B 424
LEU B 332
ALA B 314
 None
 1.01A 4p65B-3pdiB:
undetectable
4p65D-3pdiB:
undetectable
4p65G-3pdiB:
undetectable
4p65H-3pdiB:
undetectable		 4p65B-3pdiB:
6.50
4p65D-3pdiB:
6.50
4p65G-3pdiB:
7.61
4p65H-3pdiB:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr5 CARDIAC CA2+ RELEASE
CHANNEL

(Mus musculus) 		PF08709
(Ins145_P3_rec) 		5 LEU A  49
CYH A  47
LEU A  37
HIS A 193
LEU A 192
 None
 1.14A 4p65B-3qr5A:
undetectable
4p65D-3qr5A:
undetectable
4p65G-3qr5A:
undetectable
4p65H-3qr5A:
undetectable		 4p65B-3qr5A:
13.61
4p65D-3qr5A:
13.61
4p65G-3qr5A:
8.81
4p65H-3qr5A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdi PROTEASOME COMPONENT
PRE5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 LEU E 107
HIS E  73
CYH E  70
LEU E  92
ALA E 112
 None
 1.03A 4p65B-3sdiE:
undetectable
4p65D-3sdiE:
undetectable
4p65G-3sdiE:
undetectable
4p65H-3sdiE:
undetectable		 4p65B-3sdiE:
9.91
4p65D-3sdiE:
9.91
4p65G-3sdiE:
13.95
4p65H-3sdiE:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3so4 METHIONINE-ADENOSYLT
RANSFERASE

(Entamoeba
histolytica) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 LEU A 382
LEU A 388
CYH A 298
LEU A 292
LEU A 332
 None
 1.13A 4p65B-3so4A:
undetectable
4p65D-3so4A:
undetectable
4p65G-3so4A:
undetectable
4p65H-3so4A:
undetectable		 4p65B-3so4A:
3.95
4p65D-3so4A:
3.95
4p65G-3so4A:
5.50
4p65H-3so4A:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A 317
VAL A 321
LEU A 142
LEU A 277
ALA A 273
 None
 1.00A 4p65B-3tz6A:
undetectable
4p65D-3tz6A:
undetectable
4p65G-3tz6A:
undetectable
4p65H-3tz6A:
undetectable		 4p65B-3tz6A:
7.47
4p65D-3tz6A:
7.47
4p65G-3tz6A:
6.54
4p65H-3tz6A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uet ALPHA-1,3/4-FUCOSIDA
SE

(Bifidobacterium
longum) 		PF01120
(Alpha_L_fucos) 		5 LEU A 395
VAL A 461
LEU A 421
LEU A 373
ALA A 473
 None
 1.10A 4p65B-3uetA:
undetectable
4p65D-3uetA:
undetectable
4p65G-3uetA:
undetectable
4p65H-3uetA:
undetectable		 4p65B-3uetA:
4.06
4p65D-3uetA:
4.06
4p65G-3uetA:
4.32
4p65H-3uetA:
4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4alz YOP PROTEINS
TRANSLOCATION
PROTEIN D

(Yersinia
enterocolitica) 		PF16693
(Yop-YscD_ppl) 		5 LEU A 246
VAL A 279
LEU A 265
LEU A 227
ALA A 223
 None
 1.11A 4p65B-4alzA:
undetectable
4p65D-4alzA:
undetectable
4p65G-4alzA:
undetectable
4p65H-4alzA:
undetectable		 4p65B-4alzA:
10.36
4p65D-4alzA:
10.36
4p65G-4alzA:
6.15
4p65H-4alzA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amm DYNE8

(Micromonospora
chersina) 		PF00698
(Acyl_transf_1) 		5 LEU A 566
VAL A 481
CYH A 483
LEU A 543
ALA A 546
 None
 1.11A 4p65B-4ammA:
undetectable
4p65D-4ammA:
undetectable
4p65G-4ammA:
undetectable
4p65H-4ammA:
undetectable		 4p65B-4ammA:
7.05
4p65D-4ammA:
7.05
4p65G-4ammA:
5.70
4p65H-4ammA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amm DYNE8

(Micromonospora
chersina) 		PF00698
(Acyl_transf_1) 		5 VAL A 823
LEU A 843
LEU A 819
LEU A 860
ALA A 859
 None
 1.09A 4p65B-4ammA:
undetectable
4p65D-4ammA:
undetectable
4p65G-4ammA:
undetectable
4p65H-4ammA:
undetectable		 4p65B-4ammA:
7.05
4p65D-4ammA:
7.05
4p65G-4ammA:
5.70
4p65H-4ammA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA

(Drosophila
melanogaster;
Eptatretus
burgeri) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 VAL R 405
LEU R 402
LEU R 440
LEU R 421
ALA R 451
 None
 1.14A 4p65B-4bv4R:
undetectable
4p65D-4bv4R:
undetectable
4p65G-4bv4R:
undetectable
4p65H-4bv4R:
undetectable		 4p65B-4bv4R:
6.02
4p65D-4bv4R:
6.02
4p65G-4bv4R:
5.31
4p65H-4bv4R:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvg RHO-LIKE SMALL
GTPASE

(Entamoeba
histolytica) 		PF00071
(Ras) 		6 LEU A 172
VAL A  25
LEU A  96
CYH A  98
LEU A 132
ALA A 164
 None
 1.50A 4p65B-4dvgA:
undetectable
4p65D-4dvgA:
undetectable
4p65G-4dvgA:
undetectable
4p65H-4dvgA:
undetectable		 4p65B-4dvgA:
10.71
4p65D-4dvgA:
10.71
4p65G-4dvgA:
8.86
4p65H-4dvgA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h05 AMINOGLYCOSIDE-O-PHO
SPHOTRANSFERASE VIII

(Streptomyces
rimosus) 		PF01636
(APH) 		5 LEU A 113
VAL A 180
LEU A 120
LEU A 202
LEU A  62
 None
 1.10A 4p65B-4h05A:
undetectable
4p65D-4h05A:
undetectable
4p65G-4h05A:
undetectable
4p65H-4h05A:
undetectable		 4p65B-4h05A:
8.44
4p65D-4h05A:
8.44
4p65G-4h05A:
4.95
4p65H-4h05A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imv RICIN

(Ricinus
communis) 		PF00161
(RIP) 		5 VAL A  81
LEU A  74
CYH A 171
LEU A 144
LEU A  62
 None
 1.16A 4p65B-4imvA:
undetectable
4p65D-4imvA:
undetectable
4p65G-4imvA:
undetectable
4p65H-4imvA:
undetectable		 4p65B-4imvA:
15.17
4p65D-4imvA:
15.17
4p65G-4imvA:
6.45
4p65H-4imvA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 LEU A 840
VAL A 894
LEU A 797
LEU A 886
ALA A 883
 None
 1.16A 4p65B-4knhA:
undetectable
4p65D-4knhA:
undetectable
4p65G-4knhA:
undetectable
4p65H-4knhA:
undetectable		 4p65B-4knhA:
2.95
4p65D-4knhA:
2.95
4p65G-4knhA:
2.02
4p65H-4knhA:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldu AUXIN RESPONSE
FACTOR 5

(Arabidopsis
thaliana) 		PF02362
(B3)
PF06507
(Auxin_resp) 		5 LEU A 106
LEU A 102
HIS A  80
LEU A 281
ALA A 284
 None
 1.10A 4p65B-4lduA:
undetectable
4p65D-4lduA:
undetectable
4p65G-4lduA:
undetectable
4p65H-4lduA:
undetectable		 4p65B-4lduA:
6.57
4p65D-4lduA:
6.57
4p65G-4lduA:
5.37
4p65H-4lduA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6f PUTATIVE THIOSUGAR
SYNTHASE

(Amycolatopsis
orientalis) 		PF05690
(ThiG) 		5 LEU A 109
VAL A 113
LEU A 132
LEU A  94
ALA A  97
 None
 1.12A 4p65B-4n6fA:
undetectable
4p65D-4n6fA:
undetectable
4p65G-4n6fA:
undetectable
4p65H-4n6fA:
undetectable		 4p65B-4n6fA:
7.03
4p65D-4n6fA:
7.03
4p65G-4n6fA:
4.58
4p65H-4n6fA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nph PROBABLE SECRETION
SYSTEM APPARATUS ATP
SYNTHASE SSAN

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		5 LEU A 249
LEU A 325
LEU A 230
LEU A 254
ALA A 251
 None
 0.81A 4p65B-4nphA:
undetectable
4p65D-4nphA:
undetectable
4p65G-4nphA:
undetectable
4p65H-4nphA:
undetectable		 4p65B-4nphA:
8.98
4p65D-4nphA:
8.98
4p65G-4nphA:
5.99
4p65H-4nphA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pay SIDC, INTERAPTIN

(Legionella
pneumophila) 		no annotation 5 LEU A 536
VAL A 523
LEU A 527
LEU A 588
LEU A 592
 None
 1.11A 4p65B-4payA:
undetectable
4p65D-4payA:
undetectable
4p65G-4payA:
undetectable
4p65H-4payA:
undetectable		 4p65B-4payA:
4.70
4p65D-4payA:
4.70
4p65G-4payA:
3.59
4p65H-4payA:
4.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A 277
LEU A 252
LEU A 216
LEU A 213
ALA A 212
 None
 1.07A 4p65B-4ppzA:
undetectable
4p65D-4ppzA:
undetectable
4p65G-4ppzA:
undetectable
4p65H-4ppzA:
undetectable		 4p65B-4ppzA:
7.89
4p65D-4ppzA:
7.89
4p65G-4ppzA:
4.92
4p65H-4ppzA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnx TRNA
(MO5U34)-METHYLTRANS
FERASE

(Escherichia
coli) 		PF08003
(Methyltransf_9) 		5 LEU A  86
VAL A  99
LEU A  49
LEU A 167
ALA A 163
 None
 1.16A 4p65B-4qnxA:
undetectable
4p65D-4qnxA:
undetectable
4p65G-4qnxA:
undetectable
4p65H-4qnxA:
undetectable		 4p65B-4qnxA:
7.74
4p65D-4qnxA:
7.74
4p65G-4qnxA:
6.85
4p65H-4qnxA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rld ASPARTIC PROTEASE
BLA G 2

(Blattella
germanica) 		PF00026
(Asp) 		5 LEU A  53
VAL A  30
LEU A 115
LEU A 107
ALA A  49
 None
 1.00A 4p65B-4rldA:
undetectable
4p65D-4rldA:
undetectable
4p65G-4rldA:
undetectable
4p65H-4rldA:
undetectable		 4p65B-4rldA:
9.95
4p65D-4rldA:
9.95
4p65G-4rldA:
5.36
4p65H-4rldA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqo L-SERINE DEHYDRATASE

(Legionella
pneumophila) 		PF03313
(SDH_alpha)
PF03315
(SDH_beta) 		5 LEU A 425
LEU A 329
CYH A 183
LEU A 179
ALA A 176
 None
 1.16A 4p65B-4rqoA:
undetectable
4p65D-4rqoA:
undetectable
4p65G-4rqoA:
undetectable
4p65H-4rqoA:
undetectable		 4p65B-4rqoA:
5.06
4p65D-4rqoA:
5.06
4p65G-4rqoA:
5.00
4p65H-4rqoA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wja UNCHARACTERIZED
PROTEIN C9ORF142

(Homo sapiens) 		PF15384
(PAXX) 		5 LEU A  89
LEU A  47
CYH A  22
LEU A  87
ALA A  94
 None
 1.16A 4p65B-4wjaA:
undetectable
4p65D-4wjaA:
undetectable
4p65G-4wjaA:
undetectable
4p65H-4wjaA:
undetectable		 4p65B-4wjaA:
11.18
4p65D-4wjaA:
11.18
4p65G-4wjaA:
11.46
4p65H-4wjaA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase) 		5 VAL A 140
LEU A 114
LEU A 162
LEU A 127
ALA A 130
 None
 0.96A 4p65B-4x3mA:
undetectable
4p65D-4x3mA:
undetectable
4p65G-4x3mA:
undetectable
4p65H-4x3mA:
undetectable		 4p65B-4x3mA:
9.81
4p65D-4x3mA:
9.81
4p65G-4x3mA:
5.56
4p65H-4x3mA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yii UBIQUITIN-CONJUGATIN
G ENZYME E2 C

(Homo sapiens) 		PF00179
(UQ_con) 		5 LEU U  42
LEU U  35
LEU U 132
LEU U  83
ALA U  52
 None
 1.09A 4p65B-4yiiU:
undetectable
4p65D-4yiiU:
undetectable
4p65G-4yiiU:
undetectable
4p65H-4yiiU:
undetectable		 4p65B-4yiiU:
11.03
4p65D-4yiiU:
11.03
4p65G-4yiiU:
8.06
4p65H-4yiiU:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE

(Bacillus cereus) 		PF05547
(Peptidase_M6) 		5 LEU A 241
LEU A 169
HIS A 275
LEU A 274
ALA A 277
 None
 1.09A 4p65B-4yu5A:
undetectable
4p65D-4yu5A:
undetectable
4p65G-4yu5A:
undetectable
4p65H-4yu5A:
undetectable		 4p65B-4yu5A:
3.94
4p65D-4yu5A:
3.94
4p65G-4yu5A:
2.58
4p65H-4yu5A:
3.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 LEU A1069
LEU A1063
LEU A 880
CYH A 808
ALA A 876
 None
 1.13A 4p65B-5a22A:
undetectable
4p65D-5a22A:
undetectable
4p65G-5a22A:
undetectable
4p65H-5a22A:
undetectable		 4p65B-5a22A:
1.68
4p65D-5a22A:
1.68
4p65G-5a22A:
1.07
4p65H-5a22A:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 689
CYH A 603
LEU A 569
LEU A 573
ALA A 626
 None
 1.14A 4p65B-5a46A:
undetectable
4p65D-5a46A:
undetectable
4p65G-5a46A:
undetectable
4p65H-5a46A:
undetectable		 4p65B-5a46A:
6.77
4p65D-5a46A:
6.77
4p65G-5a46A:
3.95
4p65H-5a46A:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aga DNA POLYMERASE THETA

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 446
LEU A 420
LEU A 440
HIS A 417
ALA A 442
 None
 1.15A 4p65B-5agaA:
undetectable
4p65D-5agaA:
undetectable
4p65G-5agaA:
undetectable
4p65H-5agaA:
undetectable		 4p65B-5agaA:
4.51
4p65D-5agaA:
4.51
4p65G-5agaA:
2.84
4p65H-5agaA:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azd BACTERIORHODOPSIN

(Thermus
thermophilus) 		PF01036
(Bac_rhodopsin) 		5 LEU A 170
VAL A 183
LEU A 184
LEU A 113
ALA A 173
 None
 1.01A 4p65B-5azdA:
undetectable
4p65D-5azdA:
undetectable
4p65G-5azdA:
undetectable
4p65H-5azdA:
undetectable		 4p65B-5azdA:
13.04
4p65D-5azdA:
13.04
4p65G-5azdA:
16.18
4p65H-5azdA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 LEU A 391
LEU A 408
CYH A 141
LEU A 388
ALA A 389
 None
 1.14A 4p65B-5cioA:
undetectable
4p65D-5cioA:
undetectable
4p65G-5cioA:
undetectable
4p65H-5cioA:
undetectable		 4p65B-5cioA:
3.52
4p65D-5cioA:
3.52
4p65G-5cioA:
11.01
4p65H-5cioA:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckm MANNAN-BINDING
LECTIN SERINE
PEPTIDASE 2

(Rattus
norvegicus) 		PF00431
(CUB)
PF07645
(EGF_CA) 		5 LEU A  67
VAL A  58
LEU A  70
LEU A  94
LEU A  40
 None
 1.04A 4p65B-5ckmA:
undetectable
4p65D-5ckmA:
undetectable
4p65G-5ckmA:
undetectable
4p65H-5ckmA:
undetectable		 4p65B-5ckmA:
6.27
4p65D-5ckmA:
6.27
4p65G-5ckmA:
6.28
4p65H-5ckmA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Staphylococcus
aureus) 		PF13395
(HNH_4)
PF16592
(Cas9_REC) 		5 LEU A 100
HIS A 191
LEU A  76
LEU A 183
LEU A 109
 None
 1.10A 4p65B-5czzA:
undetectable
4p65D-5czzA:
undetectable
4p65G-5czzA:
undetectable
4p65H-5czzA:
undetectable		 4p65B-5czzA:
4.05
4p65D-5czzA:
4.05
4p65G-5czzA:
2.01
4p65H-5czzA:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus) 		PF00602
(Flu_PB1) 		5 VAL B 419
LEU B 416
LEU B  90
LEU B 323
ALA B 319
 None
 1.13A 4p65B-5d9aB:
undetectable
4p65D-5d9aB:
undetectable
4p65G-5d9aB:
undetectable
4p65H-5d9aB:
undetectable		 4p65B-5d9aB:
4.17
4p65D-5d9aB:
4.17
4p65G-5d9aB:
4.02
4p65H-5d9aB:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgx LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Francisella
tularensis) 		PF00005
(ABC_tran) 		5 VAL A 372
LEU A 430
HIS A 446
LEU A 447
ALA A 527
 None
 1.14A 4p65B-5dgxA:
undetectable
4p65D-5dgxA:
undetectable
4p65G-5dgxA:
undetectable
4p65H-5dgxA:
undetectable		 4p65B-5dgxA:
10.34
4p65D-5dgxA:
10.34
4p65G-5dgxA:
15.79
4p65H-5dgxA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dny DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11

(Methanocaldococcus
jannaschii) 		PF00149
(Metallophos) 		5 LEU A 100
VAL A  44
LEU A  71
LEU A  50
ALA A  64
 None
 1.08A 4p65B-5dnyA:
undetectable
4p65D-5dnyA:
undetectable
4p65G-5dnyA:
undetectable
4p65H-5dnyA:
undetectable		 4p65B-5dnyA:
6.67
4p65D-5dnyA:
6.67
4p65G-5dnyA:
4.47
4p65H-5dnyA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejy MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00784
(MyTH4) 		5 LEU A 514
LEU A 497
LEU A 466
LEU A 524
ALA A 516
 None
 1.08A 4p65B-5ejyA:
undetectable
4p65D-5ejyA:
undetectable
4p65G-5ejyA:
undetectable
4p65H-5ejyA:
undetectable		 4p65B-5ejyA:
4.74
4p65D-5ejyA:
4.74
4p65G-5ejyA:
7.26
4p65H-5ejyA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fo5 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR METR

(Escherichia
coli) 		PF00126
(HTH_1) 		5 LEU A  33
LEU A  40
LEU A  13
HIS A   6
LEU A  10
 None
 0.93A 4p65B-5fo5A:
undetectable
4p65D-5fo5A:
undetectable
4p65G-5fo5A:
undetectable
4p65H-5fo5A:
undetectable		 4p65B-5fo5A:
16.85
4p65D-5fo5A:
16.85
4p65G-5fo5A:
13.10
4p65H-5fo5A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvi UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Danio rerio) 		PF00443
(UCH) 		5 LEU A  66
LEU A 161
LEU A 119
LEU A 139
ALA A 136
 None
 1.04A 4p65B-5gviA:
undetectable
4p65D-5gviA:
undetectable
4p65G-5gviA:
undetectable
4p65H-5gviA:
undetectable		 4p65B-5gviA:
5.74
4p65D-5gviA:
5.74
4p65G-5gviA:
5.17
4p65H-5gviA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 LEU A  64
LEU A 151
HIS A  77
LEU A  89
ALA A  62
 None
 1.03A 4p65B-5hjrA:
undetectable
4p65D-5hjrA:
undetectable
4p65G-5hjrA:
undetectable
4p65H-5hjrA:
undetectable		 4p65B-5hjrA:
3.31
4p65D-5hjrA:
3.31
4p65G-5hjrA:
2.59
4p65H-5hjrA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 VAL A 557
LEU A 554
LEU A 592
LEU A 573
ALA A 603
 None
 1.13A 4p65B-5ijbA:
undetectable
4p65D-5ijbA:
undetectable
4p65G-5ijbA:
undetectable
4p65H-5ijbA:
undetectable		 4p65B-5ijbA:
4.12
4p65D-5ijbA:
4.12
4p65G-5ijbA:
3.84
4p65H-5ijbA:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7f TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Myxococcus
xanthus) 		PF00440
(TetR_N) 		5 VAL A  76
LEU A  77
LEU A  90
LEU A 138
ALA A 141
 None
 0.84A 4p65B-5k7fA:
undetectable
4p65D-5k7fA:
undetectable
4p65G-5k7fA:
undetectable
4p65H-5k7fA:
undetectable		 4p65B-5k7fA:
9.38
4p65D-5k7fA:
9.38
4p65G-5k7fA:
14.00
4p65H-5k7fA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 5 LEU A 172
CYH A 103
HIS A 131
LEU A 130
ALA A 179
 None
 1.14A 4p65B-5n6vA:
undetectable
4p65D-5n6vA:
undetectable
4p65G-5n6vA:
undetectable
4p65H-5n6vA:
undetectable		 4p65B-5n6vA:
undetectable
4p65D-5n6vA:
undetectable
4p65G-5n6vA:
undetectable
4p65H-5n6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Homo sapiens) 		PF00443
(UCH) 		5 LEU A  70
LEU A 165
LEU A 123
LEU A 143
ALA A 140
 None
 0.99A 4p65B-5ohkA:
undetectable
4p65D-5ohkA:
undetectable
4p65G-5ohkA:
undetectable
4p65H-5ohkA:
undetectable		 4p65B-5ohkA:
7.67
4p65D-5ohkA:
7.67
4p65G-5ohkA:
4.17
4p65H-5ohkA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3b GLYCOSIDE HYDROLASE

(Bacteroides
plebeius) 		no annotation 5 LEU A 192
VAL A 197
LEU A 174
CYH A 288
LEU A 242
 None
 1.06A 4p65B-5t3bA:
undetectable
4p65D-5t3bA:
undetectable
4p65G-5t3bA:
undetectable
4p65H-5t3bA:
undetectable		 4p65B-5t3bA:
4.79
4p65D-5t3bA:
4.79
4p65G-5t3bA:
4.26
4p65H-5t3bA:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4z REPRESSOR OF RNA
POLYMERASE III
TRANSCRIPTION

(Citrus sinensis) 		PF09174
(Maf1) 		5 LEU A   9
LEU A  16
LEU A 145
LEU A 141
ALA A 144
 None
 1.14A 4p65B-5u4zA:
undetectable
4p65D-5u4zA:
undetectable
4p65G-5u4zA:
undetectable
4p65H-5u4zA:
undetectable		 4p65B-5u4zA:
7.94
4p65D-5u4zA:
7.94
4p65G-5u4zA:
5.70
4p65H-5u4zA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5un0 PROTEASOME ASSEMBLY
CHAPERONE 2 (PAC2)
HOMOLOGUE RV2125

(Mycobacterium
tuberculosis) 		PF09754
(PAC2) 		5 LEU 1 129
VAL 1  95
LEU 1  97
LEU 1 209
ALA 1  35
 None
 1.09A 4p65B-5un01:
undetectable
4p65D-5un01:
undetectable
4p65G-5un01:
undetectable
4p65H-5un01:
undetectable		 4p65B-5un01:
12.79
4p65D-5un01:
12.79
4p65G-5un01:
5.53
4p65H-5un01:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux2 ALDEHYDE
DECARBONYLASE

(Synechococcus
sp. RS9917) 		no annotation 5 CYH A 110
LEU A 106
HIS A 141
LEU A 142
ALA A 145
 None
None
FE  A 301 (-3.5A)
None
None
 1.03A 4p65B-5ux2A:
undetectable
4p65D-5ux2A:
undetectable
4p65G-5ux2A:
undetectable
4p65H-5ux2A:
undetectable		 4p65B-5ux2A:
undetectable
4p65D-5ux2A:
undetectable
4p65G-5ux2A:
undetectable
4p65H-5ux2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCD

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		5 LEU B  16
VAL B 152
LEU B 115
LEU B 229
ALA B  24
 None
 1.16A 4p65B-5vipB:
undetectable
4p65D-5vipB:
undetectable
4p65G-5vipB:
undetectable
4p65H-5vipB:
undetectable		 4p65B-5vipB:
8.00
4p65D-5vipB:
8.00
4p65G-5vipB:
5.49
4p65H-5vipB:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 5 LEU A 444
VAL A 357
LEU A 437
LEU A 380
ALA A 379
 None
 1.01A 4p65B-5w19A:
undetectable
4p65D-5w19A:
undetectable
4p65G-5w19A:
undetectable
4p65H-5w19A:
undetectable		 4p65B-5w19A:
undetectable
4p65D-5w19A:
undetectable
4p65G-5w19A:
undetectable
4p65H-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4j UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 5 LEU A 459
VAL A 359
LEU A 464
LEU A 426
ALA A 429
 None
 1.07A 4p65B-5x4jA:
undetectable
4p65D-5x4jA:
undetectable
4p65G-5x4jA:
undetectable
4p65H-5x4jA:
undetectable		 4p65B-5x4jA:
undetectable
4p65D-5x4jA:
undetectable
4p65G-5x4jA:
undetectable
4p65H-5x4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeq NEUROLIGIN-2

(Homo sapiens) 		PF00135
(COesterase) 		5 LEU A 144
LEU A 183
LEU A 245
LEU A 242
ALA A 241
 None
 1.09A 4p65B-5xeqA:
undetectable
4p65D-5xeqA:
undetectable
4p65G-5xeqA:
undetectable
4p65H-5xeqA:
undetectable		 4p65B-5xeqA:
5.02
4p65D-5xeqA:
5.02
4p65G-5xeqA:
3.38
4p65H-5xeqA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn7 AEROBACTIN SYNTHASE
IUCC

(Klebsiella
pneumoniae) 		no annotation 5 LEU A  78
VAL A  84
LEU A  41
LEU A 548
LEU A  21
 None
 1.17A 4p65B-6cn7A:
undetectable
4p65D-6cn7A:
undetectable
4p65G-6cn7A:
undetectable
4p65H-6cn7A:
undetectable		 4p65B-6cn7A:
undetectable
4p65D-6cn7A:
undetectable
4p65G-6cn7A:
undetectable
4p65H-6cn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6grw -

(-) 		no annotation 5 LEU A 118
LEU A 204
LEU A 137
LEU A 243
ALA A 246
 None
 1.01A 4p65B-6grwA:
undetectable
4p65D-6grwA:
undetectable
4p65G-6grwA:
undetectable
4p65H-6grwA:
undetectable		 4p65B-6grwA:
undetectable
4p65D-6grwA:
undetectable
4p65G-6grwA:
undetectable
4p65H-6grwA:
undetectable