SIMILAR PATTERNS OF AMINO ACIDS FOR 4P65_E_IPHE101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6f PLACENTAL LACTOGEN

(Ovis aries) 		PF00103
(Hormone_1) 		5 LEU A 172
HIS A  98
LEU A  97
ALA A 100
LEU A 157
 None
 0.84A 4p65E-1f6fA:
undetectable
4p65F-1f6fA:
undetectable
4p65J-1f6fA:
undetectable
4p65L-1f6fA:
undetectable		 4p65E-1f6fA:
10.42
4p65F-1f6fA:
12.36
4p65J-1f6fA:
12.36
4p65L-1f6fA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7k UBIQUITIN-CONJUGATIN
G ENZYME E2 H10

(Homo sapiens) 		PF00179
(UQ_con) 		5 LEU A 132
LEU A  83
ALA A  52
LEU A  35
LEU A  42
 None
 0.93A 4p65E-1i7kA:
undetectable
4p65F-1i7kA:
undetectable
4p65J-1i7kA:
undetectable
4p65L-1i7kA:
undetectable		 4p65E-1i7kA:
8.06
4p65F-1i7kA:
9.47
4p65J-1i7kA:
9.47
4p65L-1i7kA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izc MACROPHOMATE
SYNTHASE
INTERMOLECULAR
DIELS-ALDERASE

(Macrophoma
commelinae) 		PF03328
(HpcH_HpaI) 		5 CYH A 179
ILE A  99
LEU A  32
ALA A  31
LEU A  43
 None
 1.09A 4p65E-1izcA:
undetectable
4p65F-1izcA:
undetectable
4p65J-1izcA:
undetectable
4p65L-1izcA:
undetectable		 4p65E-1izcA:
5.39
4p65F-1izcA:
8.30
4p65J-1izcA:
8.30
4p65L-1izcA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mj0 SANK E3_5 PROTEIN

(-) 		PF12796
(Ank_2) 		5 ILE A  95
LEU A  84
HIS A 102
LEU A 100
ALA A 104
 TRS  A 200 (-3.9A)
None
None
None
None
 1.09A 4p65E-1mj0A:
undetectable
4p65F-1mj0A:
undetectable
4p65J-1mj0A:
undetectable
4p65L-1mj0A:
undetectable		 4p65E-1mj0A:
11.01
4p65F-1mj0A:
13.51
4p65J-1mj0A:
13.51
4p65L-1mj0A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mj0 SANK E3_5 PROTEIN

(-) 		PF12796
(Ank_2) 		5 ILE A 128
LEU A 117
HIS A 135
LEU A 133
ALA A 137
 None
 1.07A 4p65E-1mj0A:
undetectable
4p65F-1mj0A:
undetectable
4p65J-1mj0A:
undetectable
4p65L-1mj0A:
undetectable		 4p65E-1mj0A:
11.01
4p65F-1mj0A:
13.51
4p65J-1mj0A:
13.51
4p65L-1mj0A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 ILE E 198
LEU E 205
ALA E 207
LEU E 148
LEU E 187
 None
 1.09A 4p65E-1nfiE:
undetectable
4p65F-1nfiE:
undetectable
4p65J-1nfiE:
undetectable
4p65L-1nfiE:
undetectable		 4p65E-1nfiE:
7.77
4p65F-1nfiE:
11.76
4p65J-1nfiE:
11.76
4p65L-1nfiE:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF13177
(DNA_pol3_delta2) 		5 ILE E 298
LEU E 332
LEU E 342
ALA E 338
LEU E 289
 None
 1.11A 4p65E-1sxjE:
undetectable
4p65F-1sxjE:
undetectable
4p65J-1sxjE:
undetectable
4p65L-1sxjE:
undetectable		 4p65E-1sxjE:
5.82
4p65F-1sxjE:
8.70
4p65J-1sxjE:
8.70
4p65L-1sxjE:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttw SECRETION CHAPERONE

(Yersinia pestis) 		PF05932
(CesT) 		5 CYH A  81
LEU A  91
LEU A 119
ALA A  54
LEU A  57
 None
 1.00A 4p65E-1ttwA:
undetectable
4p65F-1ttwA:
undetectable
4p65J-1ttwA:
undetectable
4p65L-1ttwA:
undetectable		 4p65E-1ttwA:
9.35
4p65F-1ttwA:
15.05
4p65J-1ttwA:
15.05
4p65L-1ttwA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2c UBIQUITIN
CONJUGATING ENZYME

(Spisula
solidissima) 		PF00179
(UQ_con) 		5 LEU A 132
LEU A  83
ALA A  52
LEU A  35
LEU A  42
 None
 0.97A 4p65E-2e2cA:
undetectable
4p65F-2e2cA:
undetectable
4p65J-2e2cA:
undetectable
4p65L-2e2cA:
undetectable		 4p65E-2e2cA:
9.68
4p65F-2e2cA:
9.15
4p65J-2e2cA:
9.15
4p65L-2e2cA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ery RAS-RELATED PROTEIN
R-RAS2

(Homo sapiens) 		PF00071
(Ras) 		5 ILE A  66
LEU A  90
HIS A 169
LEU A 171
ALA A 167
 None
 1.12A 4p65E-2eryA:
undetectable
4p65F-2eryA:
undetectable
4p65J-2eryA:
undetectable
4p65L-2eryA:
undetectable		 4p65E-2eryA:
9.52
4p65F-2eryA:
10.81
4p65J-2eryA:
10.81
4p65L-2eryA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnw NON-SYMBIOTIC
HEMOGLOBIN 1

(Oryza sativa) 		PF00042
(Globin) 		5 LEU A 101
HIS A 152
LEU A 153
ALA A 156
LEU A  88
 None
None
HEM  A 166 ( 4.7A)
None
None
 1.08A 4p65E-2gnwA:
undetectable
4p65F-2gnwA:
undetectable
4p65J-2gnwA:
undetectable
4p65L-2gnwA:
undetectable		 4p65E-2gnwA:
5.45
4p65F-2gnwA:
9.70
4p65J-2gnwA:
9.70
4p65L-2gnwA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		5 ILE A 264
LEU A 214
LEU A 234
ALA A 182
LEU A 180
 None
 0.98A 4p65E-2gouA:
undetectable
4p65F-2gouA:
undetectable
4p65J-2gouA:
undetectable
4p65L-2gouA:
undetectable		 4p65E-2gouA:
4.52
4p65F-2gouA:
10.14
4p65J-2gouA:
10.14
4p65L-2gouA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 LEU A 318
HIS A 385
LEU A 384
ALA A 387
LEU A 431
 None
 1.03A 4p65E-2hpiA:
undetectable
4p65F-2hpiA:
undetectable
4p65J-2hpiA:
undetectable
4p65L-2hpiA:
undetectable		 4p65E-2hpiA:
1.55
4p65F-2hpiA:
2.42
4p65J-2hpiA:
2.42
4p65L-2hpiA:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6f FOCAL ADHESION
KINASE 1, LINKER1,
PAXILLIN, LINKER2,
PAXILLIN

(Gallus gallus;
unidentified) 		PF03535
(Paxillin)
PF03623
(Focal_AT) 		5 LEU A  87
HIS A 115
LEU A 117
ALA A 113
LEU A 170
 None
 1.01A 4p65E-2l6fA:
undetectable
4p65F-2l6fA:
undetectable
4p65J-2l6fA:
undetectable
4p65L-2l6fA:
undetectable		 4p65E-2l6fA:
6.58
4p65F-2l6fA:
6.90
4p65J-2l6fA:
6.90
4p65L-2l6fA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6g FOCAL ADHESION
KINASE 1, LINKER,
PAXILLIN

(Gallus gallus;
unidentified) 		PF03535
(Paxillin)
PF03623
(Focal_AT) 		5 LEU A  87
HIS A 115
LEU A 117
ALA A 113
LEU A 170
 None
 1.11A 4p65E-2l6gA:
undetectable
4p65F-2l6gA:
undetectable
4p65J-2l6gA:
undetectable
4p65L-2l6gA:
undetectable		 4p65E-2l6gA:
8.12
4p65F-2l6gA:
7.95
4p65J-2l6gA:
7.95
4p65L-2l6gA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxp UBIQUITIN-CONJUGATIN
G ENZYME E2 G2

(Homo sapiens) 		PF00179
(UQ_con) 		5 LEU A 120
LEU A  58
ALA A  26
LEU A   9
LEU A  16
 None
 0.93A 4p65E-2lxpA:
undetectable
4p65F-2lxpA:
undetectable
4p65J-2lxpA:
undetectable
4p65L-2lxpA:
undetectable		 4p65E-2lxpA:
11.30
4p65F-2lxpA:
12.30
4p65J-2lxpA:
12.30
4p65L-2lxpA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1h HEMOGLOBIN SUBUNIT
ALPHA-4

(Oncorhynchus
mykiss) 		PF00042
(Globin) 		5 CYH A  70
LEU A  81
LEU A 133
ALA A 136
LEU A   2
 None
 1.01A 4p65E-2r1hA:
undetectable
4p65F-2r1hA:
undetectable
4p65J-2r1hA:
undetectable
4p65L-2r1hA:
undetectable		 4p65E-2r1hA:
10.94
4p65F-2r1hA:
22.08
4p65J-2r1hA:
22.08
4p65L-2r1hA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5q DESIGN ANKYRIN
REPEAT PROTEIN

(unidentified) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 ILE C  62
LEU C  51
HIS C  69
LEU C  67
ALA C  71
 None
 1.05A 4p65E-2v5qC:
undetectable
4p65F-2v5qC:
undetectable
4p65J-2v5qC:
undetectable
4p65L-2v5qC:
undetectable		 4p65E-2v5qC:
6.67
4p65F-2v5qC:
13.51
4p65J-2v5qC:
13.51
4p65L-2v5qC:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2g NON-STRUCTURAL
PROTEIN 3

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF11633
(SUD-M) 		5 ILE A 454
LEU A 437
ALA A 415
LEU A 412
LEU A 421
 None
 0.99A 4p65E-2w2gA:
undetectable
4p65F-2w2gA:
undetectable
4p65J-2w2gA:
undetectable
4p65L-2w2gA:
undetectable		 4p65E-2w2gA:
5.66
4p65F-2w2gA:
7.48
4p65J-2w2gA:
7.48
4p65L-2w2gA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzd DARPIN-3.4

(synthetic
construct) 		PF12796
(Ank_2) 		5 ILE G  62
LEU G  51
HIS G  69
LEU G  67
ALA G  71
 None
 1.00A 4p65E-2xzdG:
undetectable
4p65F-2xzdG:
undetectable
4p65J-2xzdG:
undetectable
4p65L-2xzdG:
undetectable		 4p65E-2xzdG:
7.46
4p65F-2xzdG:
14.53
4p65J-2xzdG:
14.53
4p65L-2xzdG:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 ILE A 223
LEU A 152
LEU A 169
ALA A 128
LEU A 126
 None
 1.11A 4p65E-3bc9A:
undetectable
4p65F-3bc9A:
undetectable
4p65J-3bc9A:
undetectable
4p65L-3bc9A:
undetectable		 4p65E-3bc9A:
2.58
4p65F-3bc9A:
4.47
4p65J-3bc9A:
4.47
4p65L-3bc9A:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfk SMALL GTPASE RAB11

(Plasmodium
falciparum) 		PF00071
(Ras) 		5 ILE A  65
LEU A  89
HIS A 167
LEU A 169
ALA A 165
 None
 1.10A 4p65E-3bfkA:
undetectable
4p65F-3bfkA:
undetectable
4p65J-3bfkA:
undetectable
4p65L-3bfkA:
undetectable		 4p65E-3bfkA:
7.73
4p65F-3bfkA:
10.47
4p65J-3bfkA:
10.47
4p65L-3bfkA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		5 ILE A  86
LEU A  72
HIS A 153
ALA A 127
LEU A 124
 None
 1.07A 4p65E-3bptA:
undetectable
4p65F-3bptA:
undetectable
4p65J-3bptA:
undetectable
4p65L-3bptA:
undetectable		 4p65E-3bptA:
4.74
4p65F-3bptA:
6.71
4p65J-3bptA:
6.71
4p65L-3bptA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cit SENSOR HISTIDINE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 LEU A 131
LEU A  51
ALA A  54
LEU A 155
LEU A 148
 None
 0.84A 4p65E-3citA:
undetectable
4p65F-3citA:
undetectable
4p65J-3citA:
undetectable
4p65L-3citA:
undetectable		 4p65E-3citA:
11.90
4p65F-3citA:
14.41
4p65J-3citA:
14.41
4p65L-3citA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		5 ILE A 268
LEU A 237
LEU A 259
ALA A  94
LEU A  75
 None
 0.94A 4p65E-3cq5A:
undetectable
4p65F-3cq5A:
undetectable
4p65J-3cq5A:
undetectable
4p65L-3cq5A:
undetectable		 4p65E-3cq5A:
5.69
4p65F-3cq5A:
9.39
4p65J-3cq5A:
9.39
4p65L-3cq5A:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fot 15-O-ACETYLTRANSFERA
SE

(Fusarium
sporotrichioides) 		PF07428
(Tri3) 		5 ILE A 314
CYH A 390
HIS A 308
LEU A 309
LEU A 480
 None
 1.06A 4p65E-3fotA:
undetectable
4p65F-3fotA:
undetectable
4p65J-3fotA:
undetectable
4p65L-3fotA:
undetectable		 4p65E-3fotA:
4.38
4p65F-3fotA:
6.54
4p65J-3fotA:
6.54
4p65L-3fotA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		5 ILE A 377
LEU A 350
LEU A  52
ALA A 387
LEU A 328
 None
 0.99A 4p65E-3g77A:
undetectable
4p65F-3g77A:
undetectable
4p65J-3g77A:
undetectable
4p65L-3g77A:
undetectable		 4p65E-3g77A:
4.08
4p65F-3g77A:
5.90
4p65J-3g77A:
5.90
4p65L-3g77A:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4z MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH ALLERGEN
DERP7

(Escherichia
coli;
Dermatophagoides
pteronyssinus) 		PF13416
(SBP_bac_8)
PF16984
(Grp7_allergen) 		5 ILE A 132
LEU A 139
LEU A 122
ALA A 223
LEU A 115
 None
 1.10A 4p65E-3h4zA:
undetectable
4p65F-3h4zA:
undetectable
4p65J-3h4zA:
undetectable
4p65L-3h4zA:
undetectable		 4p65E-3h4zA:
4.42
4p65F-3h4zA:
3.75
4p65J-3h4zA:
3.75
4p65L-3h4zA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhr HUMAN GROWTH HORMONE

(Homo sapiens) 		PF00103
(Hormone_1) 		5 LEU A 117
HIS A  21
LEU A  20
ALA A  17
LEU A 177
 None
 0.98A 4p65E-3hhrA:
undetectable
4p65F-3hhrA:
undetectable
4p65J-3hhrA:
undetectable
4p65L-3hhrA:
undetectable		 4p65E-3hhrA:
7.89
4p65F-3hhrA:
10.29
4p65J-3hhrA:
10.29
4p65L-3hhrA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n93 MALTOSE BINDING
PROTEIN-CRFR2 ALPHA

(Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 ILE A-238
LEU A-231
LEU A-248
ALA A-147
LEU A-255
 None
 1.08A 4p65E-3n93A:
undetectable
4p65F-3n93A:
undetectable
4p65J-3n93A:
undetectable
4p65L-3n93A:
undetectable		 4p65E-3n93A:
3.95
4p65F-3n93A:
5.70
4p65J-3n93A:
5.70
4p65L-3n93A:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob4 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ARAH 2

(Escherichia
coli;
Arachis
duranensis) 		PF00234
(Tryp_alpha_amyl)
PF13416
(SBP_bac_8) 		5 ILE A 132
LEU A 139
LEU A 122
ALA A 223
LEU A 115
 None
 1.12A 4p65E-3ob4A:
undetectable
4p65F-3ob4A:
undetectable
4p65J-3ob4A:
undetectable
4p65L-3ob4A:
undetectable		 4p65E-3ob4A:
3.23
4p65F-3ob4A:
5.29
4p65J-3ob4A:
5.29
4p65L-3ob4A:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pc3 CG1753, ISOFORM A

(Drosophila
melanogaster) 		PF00291
(PALP)
PF00571
(CBS) 		5 ILE A 457
LEU A 494
ALA A 495
LEU A 481
LEU A 468
 None
 1.07A 4p65E-3pc3A:
undetectable
4p65F-3pc3A:
undetectable
4p65J-3pc3A:
undetectable
4p65L-3pc3A:
undetectable		 4p65E-3pc3A:
3.36
4p65F-3pc3A:
5.26
4p65J-3pc3A:
5.26
4p65L-3pc3A:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plw RECOMBINATION
ENHANCEMENT FUNCTION
PROTEIN

(Escherichia
virus P1) 		PF16786
(RecA_dep_nuc) 		5 ILE A  97
LEU A  91
HIS A 112
LEU A 111
LEU A 175
 None
None
ZN  A 187 ( 3.1A)
None
None
 1.06A 4p65E-3plwA:
undetectable
4p65F-3plwA:
undetectable
4p65J-3plwA:
undetectable
4p65L-3plwA:
undetectable		 4p65E-3plwA:
8.20
4p65F-3plwA:
7.65
4p65J-3plwA:
7.65
4p65L-3plwA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9n CONSENSUS ANKYRIN
REPEAT

(Escherichia
coli) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 ILE C  83
LEU C  72
HIS C  90
LEU C  88
ALA C  92
 None
 1.06A 4p65E-3q9nC:
undetectable
4p65F-3q9nC:
undetectable
4p65J-3q9nC:
undetectable
4p65L-3q9nC:
undetectable		 4p65E-3q9nC:
8.97
4p65F-3q9nC:
11.35
4p65J-3q9nC:
11.35
4p65L-3q9nC:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9n CONSENSUS ANKYRIN
REPEAT

(Escherichia
coli) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 ILE C 116
LEU C 105
HIS C 123
LEU C 121
ALA C 125
 None
 1.08A 4p65E-3q9nC:
undetectable
4p65F-3q9nC:
undetectable
4p65J-3q9nC:
undetectable
4p65L-3q9nC:
undetectable		 4p65E-3q9nC:
8.97
4p65F-3q9nC:
11.35
4p65J-3q9nC:
11.35
4p65L-3q9nC:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdi PROTEASOME COMPONENT
PRE5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 CYH E  70
LEU E  92
ALA E 112
HIS E  73
LEU E 107
 None
 0.93A 4p65E-3sdiE:
undetectable
4p65F-3sdiE:
undetectable
4p65J-3sdiE:
undetectable
4p65L-3sdiE:
undetectable		 4p65E-3sdiE:
13.95
4p65F-3sdiE:
9.91
4p65J-3sdiE:
9.91
4p65L-3sdiE:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdi PROTEASOME COMPONENT
PRE5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 CYH E  70
LEU E  92
HIS E 147
ALA E 112
LEU E 107
 None
 1.08A 4p65E-3sdiE:
undetectable
4p65F-3sdiE:
undetectable
4p65J-3sdiE:
undetectable
4p65L-3sdiE:
undetectable		 4p65E-3sdiE:
13.95
4p65F-3sdiE:
9.91
4p65J-3sdiE:
9.91
4p65L-3sdiE:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3su8 PLEXIN-B1

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		5 HIS X2089
LEU X2088
ALA X2087
LEU X1589
LEU X1585
 None
 1.00A 4p65E-3su8X:
undetectable
4p65F-3su8X:
undetectable
4p65J-3su8X:
undetectable
4p65L-3su8X:
undetectable		 4p65E-3su8X:
3.36
4p65F-3su8X:
7.45
4p65J-3su8X:
7.45
4p65L-3su8X:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts9 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		no annotation 5 ILE A  17
HIS A  63
LEU A  64
LEU A 117
LEU A  86
 None
 1.09A 4p65E-3ts9A:
undetectable
4p65F-3ts9A:
undetectable
4p65J-3ts9A:
undetectable
4p65L-3ts9A:
undetectable		 4p65E-3ts9A:
6.57
4p65F-3ts9A:
19.75
4p65J-3ts9A:
19.75
4p65L-3ts9A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE

(Leptospirillum
rubarum) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 ILE A 209
LEU A 216
ALA A 225
LEU A 331
LEU A 227
 None
 0.93A 4p65E-3ttgA:
undetectable
4p65F-3ttgA:
undetectable
4p65J-3ttgA:
undetectable
4p65L-3ttgA:
undetectable		 4p65E-3ttgA:
5.90
4p65F-3ttgA:
8.20
4p65J-3ttgA:
8.20
4p65L-3ttgA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE

(Oryza sativa) 		PF00875
(DNA_photolyase) 		5 LEU A 206
HIS A  58
LEU A  57
ALA A  60
LEU A  70
 None
 1.06A 4p65E-3umvA:
undetectable
4p65F-3umvA:
undetectable
4p65J-3umvA:
undetectable
4p65L-3umvA:
undetectable		 4p65E-3umvA:
4.17
4p65F-3umvA:
6.14
4p65J-3umvA:
6.14
4p65L-3umvA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vd8 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
INTERFERON-INDUCIBLE
PROTEIN AIM2

(Escherichia
coli;
Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 ILE A 132
LEU A 139
LEU A 122
ALA A 223
LEU A 115
 None
 1.11A 4p65E-3vd8A:
undetectable
4p65F-3vd8A:
undetectable
4p65J-3vd8A:
undetectable
4p65L-3vd8A:
undetectable		 4p65E-3vd8A:
5.06
4p65F-3vd8A:
5.77
4p65J-3vd8A:
5.77
4p65L-3vd8A:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgf MALTO-OLIGOSYLTREHAL
OSE TREHALOHYDROLASE

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF09071
(Alpha-amyl_C) 		5 ILE A 107
LEU A 125
LEU A 182
ALA A 177
LEU A 173
 None
 1.09A 4p65E-3vgfA:
undetectable
4p65F-3vgfA:
undetectable
4p65J-3vgfA:
undetectable
4p65L-3vgfA:
undetectable		 4p65E-3vgfA:
2.72
4p65F-3vgfA:
4.51
4p65J-3vgfA:
4.51
4p65L-3vgfA:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w94 ENTEROPEPTIDASE-1

(Oryzias latipes) 		PF00089
(Trypsin) 		5 LEU A 831
HIS A 813
LEU A 812
ALA A 850
LEU A 852
 None
 1.09A 4p65E-3w94A:
undetectable
4p65F-3w94A:
undetectable
4p65J-3w94A:
undetectable
4p65L-3w94A:
undetectable		 4p65E-3w94A:
4.72
4p65F-3w94A:
9.01
4p65J-3w94A:
9.01
4p65L-3w94A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkh CELLOBIOSE
2-EPIMERASE

(Rhodothermus
marinus) 		PF07221
(GlcNAc_2-epim) 		5 ILE A 232
LEU A 267
LEU A 290
ALA A 263
LEU A 199
 None
 1.07A 4p65E-3wkhA:
undetectable
4p65F-3wkhA:
undetectable
4p65J-3wkhA:
undetectable
4p65L-3wkhA:
undetectable		 4p65E-3wkhA:
4.57
4p65F-3wkhA:
9.09
4p65J-3wkhA:
9.09
4p65L-3wkhA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu7 DESIGNED ANKYRIN
REPEAT PROTEIN

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 ILE B  62
LEU B  51
HIS B  69
LEU B  67
ALA B  71
 None
 1.06A 4p65E-3zu7B:
undetectable
4p65F-3zu7B:
undetectable
4p65J-3zu7B:
undetectable
4p65L-3zu7B:
undetectable		 4p65E-3zu7B:
5.99
4p65F-3zu7B:
13.51
4p65J-3zu7B:
13.51
4p65L-3zu7B:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuv DESIGNED ANKYRIN
REPEAT PROTEIN

(synthetic
construct) 		PF13857
(Ank_5) 		5 ILE B  95
LEU B  84
HIS B 102
LEU B 100
ALA B 104
 None
 1.12A 4p65E-3zuvB:
undetectable
4p65F-3zuvB:
undetectable
4p65J-3zuvB:
undetectable
4p65L-3zuvB:
undetectable		 4p65E-3zuvB:
7.46
4p65F-3zuvB:
13.08
4p65J-3zuvB:
13.08
4p65L-3zuvB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 LEU A 567
LEU A 249
ALA A 570
HIS A 578
LEU A 571
 None
 1.11A 4p65E-4ah6A:
undetectable
4p65F-4ah6A:
undetectable
4p65J-4ah6A:
undetectable
4p65L-4ah6A:
undetectable		 4p65E-4ah6A:
2.42
4p65F-4ah6A:
5.30
4p65J-4ah6A:
5.30
4p65L-4ah6A:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8) 		5 ILE A 133
LEU A 140
LEU A 123
ALA A 224
LEU A 116
 None
 0.97A 4p65E-4blaA:
undetectable
4p65F-4blaA:
undetectable
4p65J-4blaA:
undetectable
4p65L-4blaA:
undetectable		 4p65E-4blaA:
5.03
4p65F-4blaA:
3.41
4p65J-4blaA:
3.41
4p65L-4blaA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7m TIR
DOMAIN-CONTAINING
PROTEIN

(Brucella
melitensis) 		PF13676
(TIR_2) 		5 ILE A 148
LEU A 137
HIS A 247
LEU A 246
ALA A 243
 None
 1.06A 4p65E-4c7mA:
undetectable
4p65F-4c7mA:
undetectable
4p65J-4c7mA:
undetectable
4p65L-4c7mA:
undetectable		 4p65E-4c7mA:
14.29
4p65F-4c7mA:
19.51
4p65J-4c7mA:
19.51
4p65L-4c7mA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkb DEOXYURIDINE
TRIPHOSPHATASE

(Trypanosoma
brucei) 		PF08761
(dUTPase_2) 		5 LEU A 238
HIS A 209
ALA A 207
HIS A  82
LEU A  24
 None
None
None
DUN  A 303 (-3.7A)
DUN  A 303 (-4.3A)
 1.08A 4p65E-4dkbA:
undetectable
4p65F-4dkbA:
undetectable
4p65J-4dkbA:
undetectable
4p65L-4dkbA:
undetectable		 4p65E-4dkbA:
5.04
4p65F-4dkbA:
7.53
4p65J-4dkbA:
7.53
4p65L-4dkbA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etz PELD

(Pseudomonas
aeruginosa) 		PF13492
(GAF_3)
PF16963
(PelD_GGDEF) 		5 ILE A 303
LEU A 203
LEU A 181
ALA A 185
LEU A 171
 None
 0.99A 4p65E-4etzA:
undetectable
4p65F-4etzA:
undetectable
4p65J-4etzA:
undetectable
4p65L-4etzA:
undetectable		 4p65E-4etzA:
5.99
4p65F-4etzA:
8.12
4p65J-4etzA:
8.12
4p65L-4etzA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		5 ILE A 557
HIS A 603
LEU A 604
LEU A 676
LEU A 626
 None
 0.95A 4p65E-4gl2A:
undetectable
4p65F-4gl2A:
undetectable
4p65J-4gl2A:
undetectable
4p65L-4gl2A:
undetectable		 4p65E-4gl2A:
3.31
4p65F-4gl2A:
4.67
4p65J-4gl2A:
4.67
4p65L-4gl2A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0o ACETATE KINASE

(Entamoeba
histolytica) 		PF00871
(Acetate_kinase) 		5 CYH A 197
CYH A 206
LEU A 227
LEU A 199
HIS A 172
 None
 1.06A 4p65E-4h0oA:
undetectable
4p65F-4h0oA:
undetectable
4p65J-4h0oA:
undetectable
4p65L-4h0oA:
undetectable		 4p65E-4h0oA:
3.98
4p65F-4h0oA:
6.88
4p65J-4h0oA:
6.88
4p65L-4h0oA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrl DESIGNED ANKYRIN
REPEAT PROTEIN 9_29

(synthetic
construct) 		PF12796
(Ank_2) 		5 ILE A  62
LEU A  51
HIS A  69
LEU A  67
ALA A  71
 None
 1.05A 4p65E-4hrlA:
undetectable
4p65F-4hrlA:
undetectable
4p65J-4hrlA:
undetectable
4p65L-4hrlA:
undetectable		 4p65E-4hrlA:
5.33
4p65F-4hrlA:
11.73
4p65J-4hrlA:
11.73
4p65L-4hrlA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrn DESIGNED ANKYRIN
REPEAT PROTEIN
H10-2-G

(synthetic
construct) 		PF12796
(Ank_2) 		5 ILE A  95
LEU A  84
HIS A 102
LEU A 100
ALA A 104
 None
 1.08A 4p65E-4hrnA:
undetectable
4p65F-4hrnA:
undetectable
4p65J-4hrnA:
undetectable
4p65L-4hrnA:
undetectable		 4p65E-4hrnA:
7.46
4p65F-4hrnA:
13.91
4p65J-4hrnA:
13.91
4p65L-4hrnA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5

(Sus scrofa) 		PF00271
(Helicase_C) 		5 ILE A 556
HIS A 602
LEU A 603
LEU A 673
LEU A 625
 None
 1.09A 4p65E-4i1sA:
undetectable
4p65F-4i1sA:
undetectable
4p65J-4i1sA:
undetectable
4p65L-4i1sA:
undetectable		 4p65E-4i1sA:
5.13
4p65F-4i1sA:
7.92
4p65J-4i1sA:
7.92
4p65L-4i1sA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5

(Sus scrofa) 		PF00271
(Helicase_C) 		5 ILE A 556
LEU A 610
ALA A 609
LEU A 603
LEU A 625
 None
 1.09A 4p65E-4i1sA:
undetectable
4p65F-4i1sA:
undetectable
4p65J-4i1sA:
undetectable
4p65L-4i1sA:
undetectable		 4p65E-4i1sA:
5.13
4p65F-4i1sA:
7.92
4p65J-4i1sA:
7.92
4p65L-4i1sA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 ILE A 133
LEU A 140
LEU A 123
ALA A 224
LEU A 116
 None
 1.09A 4p65E-4ikmA:
undetectable
4p65F-4ikmA:
undetectable
4p65J-4ikmA:
undetectable
4p65L-4ikmA:
undetectable		 4p65E-4ikmA:
2.99
4p65F-4ikmA:
5.85
4p65J-4ikmA:
5.85
4p65L-4ikmA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzy CRYPTOCHROME-1

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 ILE A  67
LEU A 180
HIS A  18
ALA A 178
LEU A  23
 None
 0.95A 4p65E-4jzyA:
undetectable
4p65F-4jzyA:
undetectable
4p65J-4jzyA:
undetectable
4p65L-4jzyA:
undetectable		 4p65E-4jzyA:
4.71
4p65F-4jzyA:
6.74
4p65J-4jzyA:
6.74
4p65L-4jzyA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5a DESIGNED ANKYRIN
REPEAT PROTEIN
013_D12

(Escherichia
coli) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ILE B 128
LEU B 117
HIS B 135
LEU B 133
ALA B 137
 None
 1.11A 4p65E-4k5aB:
undetectable
4p65F-4k5aB:
undetectable
4p65J-4k5aB:
undetectable
4p65L-4k5aB:
undetectable		 4p65E-4k5aB:
7.14
4p65F-4k5aB:
11.24
4p65J-4k5aB:
11.24
4p65L-4k5aB:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lqc TCPB

(Brucella
melitensis) 		PF13676
(TIR_2) 		5 ILE A 148
LEU A 137
HIS A 247
LEU A 246
ALA A 243
 None
 1.03A 4p65E-4lqcA:
undetectable
4p65F-4lqcA:
undetectable
4p65J-4lqcA:
undetectable
4p65L-4lqcA:
undetectable		 4p65E-4lqcA:
12.50
4p65F-4lqcA:
12.40
4p65J-4lqcA:
12.40
4p65L-4lqcA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsz DARPIN D7.18

(synthetic
construct) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 ILE E  62
LEU E  51
HIS E  69
LEU E  67
ALA E  71
 None
 1.11A 4p65E-4lszE:
undetectable
4p65F-4lszE:
undetectable
4p65J-4lszE:
undetectable
4p65L-4lszE:
undetectable		 4p65E-4lszE:
7.78
4p65F-4lszE:
15.45
4p65J-4lszE:
15.45
4p65L-4lszE:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM4

(Saccharomyces
cerevisiae) 		PF01423
(LSM) 		5 ILE G  17
LEU G   7
LEU G  81
ALA G  10
LEU G  29
 None
 1.05A 4p65E-4m75G:
undetectable
4p65F-4m75G:
undetectable
4p65J-4m75G:
undetectable
4p65L-4m75G:
undetectable		 4p65E-4m75G:
8.60
4p65F-4m75G:
9.84
4p65J-4m75G:
9.84
4p65L-4m75G:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0f IGG RECEPTOR FCRN
LARGE SUBUNIT P51

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 LEU A  68
HIS A  10
LEU A  11
LEU A   8
LEU A  36
 None
 1.06A 4p65E-4n0fA:
undetectable
4p65F-4n0fA:
undetectable
4p65J-4n0fA:
undetectable
4p65L-4n0fA:
undetectable		 4p65E-4n0fA:
6.67
4p65F-4n0fA:
11.62
4p65J-4n0fA:
11.62
4p65L-4n0fA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA

(Klebsiella
pneumoniae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ILE H 534
LEU H 402
LEU H 500
ALA H 400
LEU H 493
 None
 0.97A 4p65E-4nl4H:
undetectable
4p65F-4nl4H:
undetectable
4p65J-4nl4H:
undetectable
4p65L-4nl4H:
undetectable		 4p65E-4nl4H:
2.49
4p65F-4nl4H:
3.76
4p65J-4nl4H:
3.76
4p65L-4nl4H:
3.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuf MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
NUCLEAR RECEPTOR
SUBFAMILY 0 GROUP B
MEMBER 2 CHIMERIC
CONSTRUCT

(Escherichia
coli;
Mus musculus) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		5 ILE A 134
LEU A 141
LEU A 124
ALA A 225
LEU A 117
 None
 1.10A 4p65E-4nufA:
undetectable
4p65F-4nufA:
undetectable
4p65J-4nufA:
undetectable
4p65L-4nufA:
undetectable		 4p65E-4nufA:
3.68
4p65F-4nufA:
4.44
4p65J-4nufA:
4.44
4p65L-4nufA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ILE A 219
LEU A 204
HIS A 226
LEU A 224
ALA A 228
 None
 1.08A 4p65E-4o1oA:
undetectable
4p65F-4o1oA:
undetectable
4p65J-4o1oA:
undetectable
4p65L-4o1oA:
undetectable		 4p65E-4o1oA:
2.24
4p65F-4o1oA:
3.84
4p65J-4o1oA:
3.84
4p65L-4o1oA:
3.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 LEU A 550
LEU A 566
ALA A 563
LEU A 643
LEU A 611
 None
 1.10A 4p65E-4qmeA:
undetectable
4p65F-4qmeA:
undetectable
4p65J-4qmeA:
undetectable
4p65L-4qmeA:
undetectable		 4p65E-4qmeA:
2.42
4p65F-4qmeA:
4.60
4p65J-4qmeA:
4.60
4p65L-4qmeA:
4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rx1 PUTATIVE RRNA
METHYLTRANSFERASE

(Sorangium
cellulosum) 		no annotation 5 ILE A 178
LEU A 135
LEU A 114
ALA A 137
LEU A 158
 None
 1.00A 4p65E-4rx1A:
undetectable
4p65F-4rx1A:
undetectable
4p65J-4rx1A:
undetectable
4p65L-4rx1A:
undetectable		 4p65E-4rx1A:
7.28
4p65F-4rx1A:
15.38
4p65J-4rx1A:
15.38
4p65L-4rx1A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus) 		PF01966
(HD) 		5 ILE A 298
LEU A 310
LEU A 234
ALA A 306
LEU A 281
 None
 1.05A 4p65E-4uw2A:
undetectable
4p65F-4uw2A:
undetectable
4p65J-4uw2A:
undetectable
4p65L-4uw2A:
undetectable		 4p65E-4uw2A:
4.41
4p65F-4uw2A:
5.01
4p65J-4uw2A:
5.01
4p65L-4uw2A:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wja UNCHARACTERIZED
PROTEIN C9ORF142

(Homo sapiens) 		PF15384
(PAXX) 		5 CYH A  22
LEU A  87
ALA A  94
LEU A  47
LEU A  89
 None
 1.10A 4p65E-4wjaA:
undetectable
4p65F-4wjaA:
undetectable
4p65J-4wjaA:
undetectable
4p65L-4wjaA:
undetectable		 4p65E-4wjaA:
11.46
4p65F-4wjaA:
11.18
4p65J-4wjaA:
11.18
4p65L-4wjaA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		5 ILE A 156
LEU A 163
LEU A 146
ALA A 247
LEU A 139
 None
 1.09A 4p65E-4wrnA:
undetectable
4p65F-4wrnA:
undetectable
4p65J-4wrnA:
undetectable
4p65L-4wrnA:
undetectable		 4p65E-4wrnA:
3.06
4p65F-4wrnA:
3.70
4p65J-4wrnA:
3.70
4p65L-4wrnA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xef PROTEIN-TYROSINE
KINASE 2-BETA
20-MER PEPTIDE
CONTAINING LD1 MOTIF
OF LEUPAXIN

(Homo sapiens;
Homo sapiens) 		PF03623
(Focal_AT)
no annotation 		5 LEU A 953
HIS A 981
LEU A 983
ALA A 979
LEU B  11
 None
 1.06A 4p65E-4xefA:
undetectable
4p65F-4xefA:
undetectable
4p65J-4xefA:
undetectable
4p65L-4xefA:
undetectable		 4p65E-4xefA:
6.47
4p65F-4xefA:
8.63
4p65J-4xefA:
8.63
4p65L-4xefA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yii UBIQUITIN-CONJUGATIN
G ENZYME E2 C

(Homo sapiens) 		PF00179
(UQ_con) 		5 LEU U 132
LEU U  83
ALA U  52
LEU U  35
LEU U  42
 None
 0.94A 4p65E-4yiiU:
undetectable
4p65F-4yiiU:
undetectable
4p65J-4yiiU:
undetectable
4p65L-4yiiU:
undetectable		 4p65E-4yiiU:
8.06
4p65F-4yiiU:
11.03
4p65J-4yiiU:
11.03
4p65L-4yiiU:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE

(Bacillus cereus) 		PF05547
(Peptidase_M6) 		5 LEU A 169
HIS A 275
LEU A 274
ALA A 277
LEU A 241
 None
 1.07A 4p65E-4yu5A:
undetectable
4p65F-4yu5A:
undetectable
4p65J-4yu5A:
undetectable
4p65L-4yu5A:
undetectable		 4p65E-4yu5A:
2.58
4p65F-4yu5A:
3.94
4p65J-4yu5A:
3.94
4p65L-4yu5A:
3.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ILE A  62
LEU A  51
HIS A  69
LEU A  67
ALA A  71
 None
 1.08A 4p65E-4zfhA:
undetectable
4p65F-4zfhA:
undetectable
4p65J-4zfhA:
undetectable
4p65L-4zfhA:
undetectable		 4p65E-4zfhA:
8.65
4p65F-4zfhA:
12.41
4p65J-4zfhA:
12.41
4p65L-4zfhA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ILE A 128
LEU A 117
HIS A 135
LEU A 133
ALA A 137
 None
MG  A 204 ( 3.7A)
None
None
MG  A 203 (-3.5A)
 1.10A 4p65E-4zfhA:
undetectable
4p65F-4zfhA:
undetectable
4p65J-4zfhA:
undetectable
4p65L-4zfhA:
undetectable		 4p65E-4zfhA:
8.65
4p65F-4zfhA:
12.41
4p65J-4zfhA:
12.41
4p65L-4zfhA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 LEU A1225
LEU A1216
ALA A1219
LEU A1181
LEU A1188
 None
 1.06A 4p65E-4zxiA:
undetectable
4p65F-4zxiA:
undetectable
4p65J-4zxiA:
undetectable
4p65L-4zxiA:
undetectable		 4p65E-4zxiA:
1.98
4p65F-4zxiA:
2.52
4p65J-4zxiA:
2.52
4p65L-4zxiA:
2.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		5 ILE A  62
LEU A  51
HIS A  69
LEU A  67
ALA A  71
 None
 1.10A 4p65E-5aqaA:
undetectable
4p65F-5aqaA:
undetectable
4p65J-5aqaA:
undetectable
4p65L-5aqaA:
undetectable		 4p65E-5aqaA:
3.23
4p65F-5aqaA:
5.76
4p65J-5aqaA:
5.76
4p65L-5aqaA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxo TANKYRASE-2

(Homo sapiens) 		PF12796
(Ank_2) 		5 ILE A 607
LEU A 596
HIS A 614
LEU A 612
ALA A 616
 None
None
SO4  A 702 (-4.0A)
None
None
 1.10A 4p65E-5bxoA:
undetectable
4p65F-5bxoA:
undetectable
4p65J-5bxoA:
undetectable
4p65L-5bxoA:
undetectable		 4p65E-5bxoA:
13.86
4p65F-5bxoA:
10.98
4p65J-5bxoA:
10.98
4p65L-5bxoA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19

(Escherichia
coli;
Tetrahymena
thermophila) 		PF13416
(SBP_bac_8) 		5 ILE A 132
LEU A 139
LEU A 122
ALA A 223
LEU A 115
 None
 1.06A 4p65E-5dfmA:
undetectable
4p65F-5dfmA:
undetectable
4p65J-5dfmA:
undetectable
4p65L-5dfmA:
undetectable		 4p65E-5dfmA:
2.62
4p65F-5dfmA:
5.57
4p65J-5dfmA:
5.57
4p65L-5dfmA:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5

(Saccharomyces
cerevisiae) 		PF12717
(Cnd1) 		5 ILE A 277
LEU A 235
HIS A 263
LEU A 265
LEU A 302
 None
 1.07A 4p65E-5frsA:
undetectable
4p65F-5frsA:
undetectable
4p65J-5frsA:
undetectable
4p65L-5frsA:
undetectable		 4p65E-5frsA:
3.21
4p65F-5frsA:
5.45
4p65J-5frsA:
5.45
4p65L-5frsA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 ILE A 133
LEU A 140
LEU A 123
ALA A 224
LEU A 116
 None
 1.11A 4p65E-5h7nA:
undetectable
4p65F-5h7nA:
undetectable
4p65J-5h7nA:
undetectable
4p65L-5h7nA:
undetectable		 4p65E-5h7nA:
4.35
4p65F-5h7nA:
5.88
4p65J-5h7nA:
5.88
4p65L-5h7nA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 LEU A 151
HIS A  77
LEU A  89
ALA A  62
LEU A  64
 None
 0.93A 4p65E-5hjrA:
undetectable
4p65F-5hjrA:
undetectable
4p65J-5hjrA:
undetectable
4p65L-5hjrA:
undetectable		 4p65E-5hjrA:
2.59
4p65F-5hjrA:
3.31
4p65J-5hjrA:
3.31
4p65L-5hjrA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itz DESIGNED ANKYRIN
REPEAT PROTEIN
(DARPIN) D1

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 ILE F  62
LEU F  51
HIS F  69
LEU F  67
ALA F  71
 None
 1.08A 4p65E-5itzF:
undetectable
4p65F-5itzF:
undetectable
4p65J-5itzF:
undetectable
4p65L-5itzF:
undetectable		 4p65E-5itzF:
7.69
4p65F-5itzF:
13.49
4p65J-5itzF:
13.49
4p65L-5itzF:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		5 ILE A 236
HIS A 283
LEU A 284
LEU A 324
LEU A 306
 None
 1.06A 4p65E-5jbgA:
undetectable
4p65F-5jbgA:
undetectable
4p65J-5jbgA:
undetectable
4p65L-5jbgA:
undetectable		 4p65E-5jbgA:
2.84
4p65F-5jbgA:
4.00
4p65J-5jbgA:
4.00
4p65L-5jbgA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knh DARPIN 6G9

(synthetic
construct) 		PF12796
(Ank_2) 		5 ILE D 128
LEU D 117
HIS D 135
LEU D 133
ALA D 137
 None
 1.11A 4p65E-5knhD:
undetectable
4p65F-5knhD:
undetectable
4p65J-5knhD:
undetectable
4p65L-5knhD:
undetectable		 4p65E-5knhD:
8.94
4p65F-5knhD:
13.25
4p65J-5knhD:
13.25
4p65L-5knhD:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Mus musculus) 		no annotation 5 LEU A 531
HIS A 539
LEU A 538
LEU A 624
LEU A 615
 SME  A 519 ( 3.7A)
None
None
None
None
 1.10A 4p65E-5mhfA:
undetectable
4p65F-5mhfA:
undetectable
4p65J-5mhfA:
undetectable
4p65L-5mhfA:
undetectable		 4p65E-5mhfA:
undetectable
4p65F-5mhfA:
undetectable
4p65J-5mhfA:
undetectable
4p65L-5mhfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN

(Homo sapiens) 		PF00023
(Ank)
PF00225
(Kinesin)
PF12796
(Ank_2) 		5 ILE C 671
LEU C 660
HIS C 678
LEU C 676
ALA C 680
 None
 1.08A 4p65E-5mioC:
undetectable
4p65F-5mioC:
undetectable
4p65J-5mioC:
undetectable
4p65L-5mioC:
undetectable		 4p65E-5mioC:
5.60
4p65F-5mioC:
5.69
4p65J-5mioC:
5.69
4p65L-5mioC:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU A 519
LEU A 540
ALA A 543
LEU A 504
LEU A 511
 None
 1.04A 4p65E-5mkkA:
undetectable
4p65F-5mkkA:
undetectable
4p65J-5mkkA:
undetectable
4p65L-5mkkA:
undetectable		 4p65E-5mkkA:
7.95
4p65F-5mkkA:
4.65
4p65J-5mkkA:
4.65
4p65L-5mkkA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL

(Homo sapiens) 		PF07147
(PDCD9) 		5 LEU 5 198
HIS 5 420
LEU 5 419
ALA 5 422
HIS 5 289
 None
 0.97A 4p65E-5ool5:
undetectable
4p65F-5ool5:
undetectable
4p65J-5ool5:
undetectable
4p65L-5ool5:
undetectable		 4p65E-5ool5:
4.70
4p65F-5ool5:
6.42
4p65J-5ool5:
6.42
4p65L-5ool5:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA

(Acinetobacter
baumannii;
Escherichia
coli) 		no annotation 5 ILE A 132
LEU A 139
LEU A 122
ALA A 223
LEU A 115
 None
 1.08A 4p65E-5vawA:
undetectable
4p65F-5vawA:
undetectable
4p65J-5vawA:
undetectable
4p65L-5vawA:
undetectable		 4p65E-5vawA:
undetectable
4p65F-5vawA:
undetectable
4p65J-5vawA:
undetectable
4p65L-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x06 DNAA REGULATORY
INACTIVATOR HDA

(Escherichia
coli) 		no annotation 5 ILE E  46
LEU E  98
LEU E  60
ALA E  63
LEU E  38
 None
 1.04A 4p65E-5x06E:
undetectable
4p65F-5x06E:
undetectable
4p65J-5x06E:
undetectable
4p65L-5x06E:
undetectable		 4p65E-5x06E:
undetectable
4p65F-5x06E:
undetectable
4p65J-5x06E:
undetectable
4p65L-5x06E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4f ANKYRIN-2

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		5 ILE A 511
LEU A 500
HIS A 518
LEU A 516
ALA A 520
 None
 1.11A 4p65E-5y4fA:
undetectable
4p65F-5y4fA:
undetectable
4p65J-5y4fA:
undetectable
4p65L-5y4fA:
undetectable		 4p65E-5y4fA:
4.64
4p65F-5y4fA:
5.13
4p65J-5y4fA:
5.13
4p65L-5y4fA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE

(Bacillus
alcalophilus) 		no annotation 5 CYH A  84
ILE A  82
LEU A 109
ALA A 112
LEU A 135
 None
 1.05A 4p65E-5yo8A:
undetectable
4p65F-5yo8A:
undetectable
4p65J-5yo8A:
undetectable
4p65L-5yo8A:
undetectable		 4p65E-5yo8A:
undetectable
4p65F-5yo8A:
undetectable
4p65J-5yo8A:
undetectable
4p65L-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN

(Escherichia
coli) 		no annotation 5 ILE A 133
LEU A 140
LEU A 123
ALA A 224
LEU A 116
 None
 1.10A 4p65E-5z0rA:
undetectable
4p65F-5z0rA:
undetectable
4p65J-5z0rA:
undetectable
4p65L-5z0rA:
undetectable		 4p65E-5z0rA:
undetectable
4p65F-5z0rA:
undetectable
4p65J-5z0rA:
undetectable
4p65L-5z0rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 SODIUM-COUPLED
NEUTRAL AMINO ACID
TRANSPORTER 9

(Danio rerio) 		no annotation 5 ILE C 123
LEU C 418
LEU C 316
ALA C 431
LEU C 435
 None
 1.06A 4p65E-6c08C:
undetectable
4p65F-6c08C:
undetectable
4p65J-6c08C:
undetectable
4p65L-6c08C:
undetectable		 4p65E-6c08C:
undetectable
4p65F-6c08C:
undetectable
4p65J-6c08C:
undetectable
4p65L-6c08C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c33 5'-3' EXONUCLEASE

(Mycolicibacterium
smegmatis) 		no annotation 5 LEU A 253
LEU A 235
ALA A 238
HIS A 228
LEU A 245
 None
 0.85A 4p65E-6c33A:
undetectable
4p65F-6c33A:
undetectable
4p65J-6c33A:
undetectable
4p65L-6c33A:
undetectable		 4p65E-6c33A:
undetectable
4p65F-6c33A:
undetectable
4p65J-6c33A:
undetectable
4p65L-6c33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cf6 TANKYRASE-1

(Mus musculus) 		no annotation 5 ILE A 377
LEU A 366
HIS A 384
LEU A 382
ALA A 386
 None
 1.06A 4p65E-6cf6A:
undetectable
4p65F-6cf6A:
undetectable
4p65J-6cf6A:
undetectable
4p65L-6cf6A:
undetectable		 4p65E-6cf6A:
undetectable
4p65F-6cf6A:
undetectable
4p65J-6cf6A:
undetectable
4p65L-6cf6A:
undetectable