SIMILAR PATTERNS OF AMINO ACIDS FOR 4P65_C_IPHC101

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1a27	17-BETA-HYDROXYSTERO ID-DEHYDROGENASE (Homo sapiens)	PF00106 (adh_short)	5	CYH A 166 LEU A 165 ALA A 161 VAL A 139 LEU A 182	None	0.97A	4p65C-1a27A: undetectable 4p65D-1a27A: undetectable 4p65J-1a27A: undetectable 4p65L-1a27A: undetectable	4p65C-1a27A: 5.42 4p65D-1a27A: 7.17 4p65J-1a27A: 7.17 4p65L-1a27A: 7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1f6f	PLACENTAL LACTOGEN (Ovis aries)	PF00103 (Hormone_1)	5	LEU A 172 HIS A  98 LEU A  97 ALA A 100 LEU A 157	None	1.03A	4p65C-1f6fA: undetectable 4p65D-1f6fA: undetectable 4p65J-1f6fA: undetectable 4p65L-1f6fA: undetectable	4p65C-1f6fA: 10.42 4p65D-1f6fA: 12.36 4p65J-1f6fA: 12.36 4p65L-1f6fA: 12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1fdw	17-BETA-HYDROXYSTERO ID DEHYDROGENASE (Homo sapiens)	PF00106 (adh_short)	5	CYH A 166 LEU A 165 ALA A 161 VAL A 139 LEU A 182	None	0.97A	4p65C-1fdwA: undetectable 4p65D-1fdwA: undetectable 4p65J-1fdwA: undetectable 4p65L-1fdwA: undetectable	4p65C-1fdwA: 5.66 4p65D-1fdwA: 6.77 4p65J-1fdwA: 6.77 4p65L-1fdwA: 6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1gzk	RAC-BETA SERINE/THREONINE PROTEIN KINASE (Homo sapiens)	PF00069 (Pkinase) PF00433 (Pkinase_C)	5	CYH A 345 LEU A 381 LEU A 373 ALA A 377 VAL A 246	None	1.04A	4p65C-1gzkA: undetectable 4p65D-1gzkA: undetectable 4p65J-1gzkA: undetectable 4p65L-1gzkA: undetectable	4p65C-1gzkA: 7.94 4p65D-1gzkA: 10.13 4p65J-1gzkA: 10.13 4p65L-1gzkA: 10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1i7k	UBIQUITIN-CONJUGATIN G ENZYME E2 H10 (Homo sapiens)	PF00179 (UQ_con)	5	LEU A 132 LEU A  83 ALA A  52 LEU A  42 LEU A  35	None	0.97A	4p65C-1i7kA: undetectable 4p65D-1i7kA: undetectable 4p65J-1i7kA: undetectable 4p65L-1i7kA: undetectable	4p65C-1i7kA: 8.06 4p65D-1i7kA: 9.47 4p65J-1i7kA: 9.47 4p65L-1i7kA: 9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1j33	COBT (Thermus thermophilus)	PF02277 (DBI_PRT)	5	LEU A 290 LEU A 259 ALA A 258 LEU A 249 HIS A 283	None	1.07A	4p65C-1j33A: undetectable 4p65D-1j33A: undetectable 4p65J-1j33A: undetectable 4p65L-1j33A: undetectable	4p65C-1j33A: 5.83 4p65D-1j33A: 5.52 4p65J-1j33A: 5.52 4p65L-1j33A: 5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1jed	SULFATE ADENYLYLTRANSFERASE (Saccharomyces cerevisiae)	PF01747 (ATP-sulfurylase) PF14306 (PUA_2)	5	LEU A 158 LEU A 104 ALA A 113 LEU A  49 LEU A  42	None	1.09A	4p65C-1jedA: undetectable 4p65D-1jedA: undetectable 4p65J-1jedA: undetectable 4p65L-1jedA: undetectable	4p65C-1jedA: 3.00 4p65D-1jedA: 7.01 4p65J-1jedA: 7.01 4p65L-1jedA: 7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1knb	ADENOVIRUS TYPE 5 FIBER PROTEIN (Human mastadenovirus C)	PF00541 (Adeno_knob)	5	LEU A 413 LEU A 445 ALA A 440 VAL A 530 LEU A 522	None	1.16A	4p65C-1knbA: undetectable 4p65D-1knbA: undetectable 4p65J-1knbA: undetectable 4p65L-1knbA: undetectable	4p65C-1knbA: 6.70 4p65D-1knbA: 10.22 4p65J-1knbA: 10.22 4p65L-1knbA: 10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1luf	MUSCLE-SPECIFIC TYROSINE KINASE RECEPTOR MUSK (Rattus norvegicus)	PF07714 (Pkinase_Tyr)	5	LEU A 855 CYH A 698 LEU A 702 ALA A 705 LEU A 791	None	0.99A	4p65C-1lufA: undetectable 4p65D-1lufA: undetectable 4p65J-1lufA: undetectable 4p65L-1lufA: undetectable	4p65C-1lufA: 4.47 4p65D-1lufA: 6.34 4p65J-1lufA: 6.34 4p65L-1lufA: 6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1n7j	PHENYLETHANOLAMINE N-METHYLTRANSFERASE (Homo sapiens)	PF01234 (NNMT_PNMT_TEMT)	5	LEU A 243 LEU A 213 ALA A 275 LEU A 253 VAL A 234	None	1.10A	4p65C-1n7jA: undetectable 4p65D-1n7jA: undetectable 4p65J-1n7jA: undetectable 4p65L-1n7jA: undetectable	4p65C-1n7jA: 20.75 4p65D-1n7jA: 8.03 4p65J-1n7jA: 8.03 4p65L-1n7jA: 8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1re5	3-CARBOXY-CIS,CIS-MU CONATE CYCLOISOMERASE (Pseudomonas putida)	PF00206 (Lyase_1) PF10397 (ADSL_C)	5	LEU A 173 LEU A 129 LEU A 247 VAL A 239 LEU A 240	None	1.14A	4p65C-1re5A: undetectable 4p65D-1re5A: undetectable 4p65J-1re5A: undetectable 4p65L-1re5A: undetectable	4p65C-1re5A: 3.99 4p65D-1re5A: 5.12 4p65J-1re5A: 5.12 4p65L-1re5A: 5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1tqy	ACTINORHODIN POLYKETIDE PUTATIVE BETA-KETOACYL SYNTHASE 2 (Streptomyces coelicolor)	PF00109 (ketoacyl-synt) PF02801 (Ketoacyl-synt_C)	5	LEU B 165 LEU B 168 ALA B 398 VAL B 343 LEU B 346	None	1.11A	4p65C-1tqyB: undetectable 4p65D-1tqyB: undetectable 4p65J-1tqyB: undetectable 4p65L-1tqyB: undetectable	4p65C-1tqyB: 5.47 4p65D-1tqyB: 8.84 4p65J-1tqyB: 8.84 4p65L-1tqyB: 8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ttw	SECRETION CHAPERONE (Yersinia pestis)	PF05932 (CesT)	5	CYH A  81 LEU A  91 LEU A 119 ALA A  54 LEU A  57	None	0.95A	4p65C-1ttwA: undetectable 4p65D-1ttwA: undetectable 4p65J-1ttwA: undetectable 4p65L-1ttwA: undetectable	4p65C-1ttwA: 9.35 4p65D-1ttwA: 15.05 4p65J-1ttwA: 15.05 4p65L-1ttwA: 15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1wlj	INTERFERON STIMULATED GENE 20KDA (Homo sapiens)	PF00929 (RNase_T)	5	CYH A  28 LEU A  25 LEU A  98 ALA A  97 LEU A  91	None	1.14A	4p65C-1wljA: undetectable 4p65D-1wljA: undetectable 4p65J-1wljA: undetectable 4p65L-1wljA: undetectable	4p65C-1wljA: 7.84 4p65D-1wljA: 11.39 4p65J-1wljA: 11.39 4p65L-1wljA: 11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1xm9	PLAKOPHILIN 1 (Homo sapiens)	PF00514 (Arm)	5	LEU A 296 LEU A 311 ALA A 308 LEU A 350 LEU A 357	None	1.12A	4p65C-1xm9A: undetectable 4p65D-1xm9A: undetectable 4p65J-1xm9A: undetectable 4p65L-1xm9A: undetectable	4p65C-1xm9A: 3.86 4p65D-1xm9A: 6.67 4p65J-1xm9A: 6.67 4p65L-1xm9A: 6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2b8e	CATION-TRANSPORTING ATPASE (Archaeoglobus fulgidus)	PF00702 (Hydrolase)	5	LEU A 429 LEU A 655 ALA A 554 LEU A 586 VAL A 421	None	1.12A	4p65C-2b8eA: undetectable 4p65D-2b8eA: undetectable 4p65J-2b8eA: undetectable 4p65L-2b8eA: undetectable	4p65C-2b8eA: 8.70 4p65D-2b8eA: 8.13 4p65J-2b8eA: 8.13 4p65L-2b8eA: 8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2b8e	CATION-TRANSPORTING ATPASE (Archaeoglobus fulgidus)	PF00702 (Hydrolase)	5	LEU A 655 ALA A 554 LEU A 586 VAL A 421 LEU A 561	None	0.96A	4p65C-2b8eA: undetectable 4p65D-2b8eA: undetectable 4p65J-2b8eA: undetectable 4p65L-2b8eA: undetectable	4p65C-2b8eA: 8.70 4p65D-2b8eA: 8.13 4p65J-2b8eA: 8.13 4p65L-2b8eA: 8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2d96	NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT (Homo sapiens)	PF00531 (Death)	5	LEU A  36 LEU A  77 ALA A  76 LEU A  40 LEU A  70	None	1.03A	4p65C-2d96A: undetectable 4p65D-2d96A: undetectable 4p65J-2d96A: undetectable 4p65L-2d96A: undetectable	4p65C-2d96A: 9.17 4p65D-2d96A: 15.84 4p65J-2d96A: 15.84 4p65L-2d96A: 15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2dul	N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE (Pyrococcus horikoshii)	PF02005 (TRM)	5	LEU A 233 LEU A 151 ALA A 154 VAL A 162 LEU A 137	None	0.87A	4p65C-2dulA: undetectable 4p65D-2dulA: undetectable 4p65J-2dulA: undetectable 4p65L-2dulA: undetectable	4p65C-2dulA: 4.18 4p65D-2dulA: 6.12 4p65J-2dulA: 6.12 4p65L-2dulA: 6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2e2c	UBIQUITIN CONJUGATING ENZYME (Spisula solidissima)	PF00179 (UQ_con)	5	LEU A 132 LEU A  83 ALA A  52 LEU A  42 LEU A  35	None	1.03A	4p65C-2e2cA: undetectable 4p65D-2e2cA: undetectable 4p65J-2e2cA: undetectable 4p65L-2e2cA: undetectable	4p65C-2e2cA: 9.68 4p65D-2e2cA: 9.15 4p65J-2e2cA: 9.15 4p65L-2e2cA: 9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2efj	3,7-DIMETHYLXANTHINE METHYLTRANSFERASE (Coffea canephora)	PF03492 (Methyltransf_7)	5	LEU A  47 CYH A  38 LEU A  42 ALA A  45 LEU A 287	None	1.06A	4p65C-2efjA: undetectable 4p65D-2efjA: undetectable 4p65J-2efjA: undetectable 4p65L-2efjA: undetectable	4p65C-2efjA: 6.36 4p65D-2efjA: 6.16 4p65J-2efjA: 6.16 4p65L-2efjA: 6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ffh	PROTEIN (FFH) (Thermus aquaticus)	PF00448 (SRP54) PF02881 (SRP54_N) PF02978 (SRP_SPB)	5	LEU A 257 LEU A   5 LEU A  86 VAL A  78 LEU A 292	None	1.12A	4p65C-2ffhA: undetectable 4p65D-2ffhA: undetectable 4p65J-2ffhA: undetectable 4p65L-2ffhA: undetectable	4p65C-2ffhA: 4.72 4p65D-2ffhA: 6.36 4p65J-2ffhA: 6.36 4p65L-2ffhA: 6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2g8l	287AA LONG HYPOTHETICAL PROTEIN (Pyrococcus horikoshii)	PF01937 (DUF89)	5	LEU A 167 CYH A 280 LEU A 259 ALA A 104 LEU A 133	None	1.12A	4p65C-2g8lA: undetectable 4p65D-2g8lA: undetectable 4p65J-2g8lA: undetectable 4p65L-2g8lA: undetectable	4p65C-2g8lA: 4.42 4p65D-2g8lA: 7.17 4p65J-2g8lA: 7.17 4p65L-2g8lA: 7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2gnw	NON-SYMBIOTIC HEMOGLOBIN 1 (Oryza sativa)	PF00042 (Globin)	5	LEU A 101 HIS A 152 LEU A 153 ALA A 156 LEU A  88	None None HEM  A 166 ( 4.7A) None None	1.08A	4p65C-2gnwA: undetectable 4p65D-2gnwA: undetectable 4p65J-2gnwA: undetectable 4p65L-2gnwA: undetectable	4p65C-2gnwA: 5.45 4p65D-2gnwA: 9.70 4p65J-2gnwA: 9.70 4p65L-2gnwA: 9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2lxp	UBIQUITIN-CONJUGATIN G ENZYME E2 G2 (Homo sapiens)	PF00179 (UQ_con)	5	LEU A 120 LEU A  58 ALA A  26 LEU A  16 LEU A   9	None	0.95A	4p65C-2lxpA: undetectable 4p65D-2lxpA: undetectable 4p65J-2lxpA: undetectable 4p65L-2lxpA: undetectable	4p65C-2lxpA: 11.30 4p65D-2lxpA: 12.30 4p65J-2lxpA: 12.30 4p65L-2lxpA: 12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ng1	SIGNAL SEQUENCE RECOGNITION PROTEIN FFH (Thermus aquaticus)	PF00448 (SRP54) PF02881 (SRP54_N)	5	LEU A 257 LEU A   5 LEU A  86 VAL A  78 LEU A 292	None	1.11A	4p65C-2ng1A: undetectable 4p65D-2ng1A: undetectable 4p65J-2ng1A: undetectable 4p65L-2ng1A: undetectable	4p65C-2ng1A: 5.15 4p65D-2ng1A: 7.64 4p65J-2ng1A: 7.64 4p65L-2ng1A: 7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2q0f	RNA URIDYLYL TRANSFERASE (Trypanosoma brucei)	PF03828 (PAP_assoc)	5	HIS A 320 LEU A 321 ALA A 324 LEU A 329 LEU A 177	None	1.04A	4p65C-2q0fA: undetectable 4p65D-2q0fA: undetectable 4p65J-2q0fA: undetectable 4p65L-2q0fA: undetectable	4p65C-2q0fA: 5.48 4p65D-2q0fA: 6.34 4p65J-2q0fA: 6.34 4p65L-2q0fA: 6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2q0f	RNA URIDYLYL TRANSFERASE (Trypanosoma brucei)	PF03828 (PAP_assoc)	5	LEU A 245 HIS A 320 ALA A 324 LEU A 329 LEU A 177	None	1.13A	4p65C-2q0fA: undetectable 4p65D-2q0fA: undetectable 4p65J-2q0fA: undetectable 4p65L-2q0fA: undetectable	4p65C-2q0fA: 5.48 4p65D-2q0fA: 6.34 4p65J-2q0fA: 6.34 4p65L-2q0fA: 6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2r1h	HEMOGLOBIN SUBUNIT ALPHA-4 (Oncorhynchus mykiss)	PF00042 (Globin)	5	CYH A  70 LEU A  81 LEU A 133 ALA A 136 LEU A   2	None	1.05A	4p65C-2r1hA: undetectable 4p65D-2r1hA: undetectable 4p65J-2r1hA: undetectable 4p65L-2r1hA: undetectable	4p65C-2r1hA: 10.94 4p65D-2r1hA: 22.08 4p65J-2r1hA: 22.08 4p65L-2r1hA: 22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2rg4	UNCHARACTERIZED PROTEIN (Oceanicola granulosus)	PF13759 (2OG-FeII_Oxy_5)	5	LEU A  76 LEU A  19 VAL A  84 HIS A  83 LEU A 180	None	0.97A	4p65C-2rg4A: undetectable 4p65D-2rg4A: undetectable 4p65J-2rg4A: undetectable 4p65L-2rg4A: undetectable	4p65C-2rg4A: 7.57 4p65D-2rg4A: 10.98 4p65J-2rg4A: 10.98 4p65L-2rg4A: 10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2voy	CATION-TRANSPORTING ATPASE (Archaeoglobus fulgidus)	PF00702 (Hydrolase)	5	LEU I 429 LEU I 655 ALA I 554 LEU I 586 VAL I 421	None	1.12A	4p65C-2voyI: undetectable 4p65D-2voyI: undetectable 4p65J-2voyI: undetectable 4p65L-2voyI: undetectable	4p65C-2voyI: 9.89 4p65D-2voyI: 15.15 4p65J-2voyI: 15.15 4p65L-2voyI: 15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2voy	CATION-TRANSPORTING ATPASE (Archaeoglobus fulgidus)	PF00702 (Hydrolase)	5	LEU I 655 ALA I 554 LEU I 586 VAL I 421 LEU I 561	None	0.96A	4p65C-2voyI: undetectable 4p65D-2voyI: undetectable 4p65J-2voyI: undetectable 4p65L-2voyI: undetectable	4p65C-2voyI: 9.89 4p65D-2voyI: 15.15 4p65J-2voyI: 15.15 4p65L-2voyI: 15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2x8u	SERINE PALMITOYLTRANSFERASE (Sphingomonas wittichii)	PF00155 (Aminotran_1_2)	5	LEU A 373 HIS A 310 LEU A 309 VAL A 332 LEU A 320	None	1.05A	4p65C-2x8uA: undetectable 4p65D-2x8uA: undetectable 4p65J-2x8uA: undetectable 4p65L-2x8uA: undetectable	4p65C-2x8uA: 12.04 4p65D-2x8uA: 6.76 4p65J-2x8uA: 6.76 4p65L-2x8uA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2yzm	D-ALANINE--D-ALANINE LIGASE (Thermus thermophilus)	PF01820 (Dala_Dala_lig_N) PF07478 (Dala_Dala_lig_C)	5	LEU A  69 ALA A  35 LEU A   4 VAL A  91 LEU A  81	None	1.16A	4p65C-2yzmA: undetectable 4p65D-2yzmA: undetectable 4p65J-2yzmA: undetectable 4p65L-2yzmA: undetectable	4p65C-2yzmA: 4.38 4p65D-2yzmA: 7.21 4p65J-2yzmA: 7.21 4p65L-2yzmA: 7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3bvc	UNCHARACTERIZED PROTEIN ISM_01780 (Roseovarius nubinhibens)	PF13759 (2OG-FeII_Oxy_5)	5	LEU A  76 LEU A  19 VAL A  84 HIS A  83 LEU A 180	None	1.03A	4p65C-3bvcA: undetectable 4p65D-3bvcA: undetectable 4p65J-3bvcA: undetectable 4p65L-3bvcA: undetectable	4p65C-3bvcA: 7.57 4p65D-3bvcA: 10.24 4p65J-3bvcA: 10.24 4p65L-3bvcA: 10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3cit	SENSOR HISTIDINE KINASE (Pseudomonas syringae group genomosp. 3)	no annotation	5	LEU A 131 LEU A  51 ALA A  54 LEU A 148 LEU A 155	None	0.92A	4p65C-3citA: undetectable 4p65D-3citA: undetectable 4p65J-3citA: undetectable 4p65L-3citA: undetectable	4p65C-3citA: 11.90 4p65D-3citA: 14.41 4p65J-3citA: 14.41 4p65L-3citA: 14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3e7w	D-ALANINE--POLY(PHOS PHORIBITOL) LIGASE SUBUNIT 1 (Bacillus subtilis)	PF00501 (AMP-binding) PF13193 (AMP-binding_C)	5	LEU A 206 CYH A 214 LEU A 212 ALA A  19 LEU A  32	None	1.08A	4p65C-3e7wA: undetectable 4p65D-3e7wA: undetectable 4p65J-3e7wA: undetectable 4p65L-3e7wA: undetectable	4p65C-3e7wA: 3.91 4p65D-3e7wA: 7.97 4p65J-3e7wA: 7.97 4p65L-3e7wA: 7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ef1	RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE (Schizosaccharomyces pombe)	PF03031 (NIF) PF12738 (PTCB-BRCT)	5	LEU A 491 LEU A 496 ALA A 517 LEU A 566 VAL A 557	None	1.10A	4p65C-3ef1A: undetectable 4p65D-3ef1A: undetectable 4p65J-3ef1A: undetectable 4p65L-3ef1A: undetectable	4p65C-3ef1A: 6.28 4p65D-3ef1A: 4.56 4p65J-3ef1A: 4.56 4p65L-3ef1A: 4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3g8m	SERINE HYDROXYMETHYLTRANSFE RASE (Escherichia coli)	PF00464 (SHMT)	5	LEU A 390 LEU A 337 ALA A 333 LEU A 323 VAL A 364	None	1.02A	4p65C-3g8mA: undetectable 4p65D-3g8mA: undetectable 4p65J-3g8mA: undetectable 4p65L-3g8mA: undetectable	4p65C-3g8mA: 4.90 4p65D-3g8mA: 6.49 4p65J-3g8mA: 6.49 4p65L-3g8mA: 6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3gdj	HEMOGLOBIN SUBUNIT BETA (Camelus dromedarius)	PF00042 (Globin)	5	LEU B 126 HIS B  12 LEU B  14 ALA B  10 LEU B  75	None	1.14A	4p65C-3gdjB: undetectable 4p65D-3gdjB: undetectable 4p65J-3gdjB: undetectable 4p65L-3gdjB: undetectable	4p65C-3gdjB: 5.63 4p65D-3gdjB: 12.26 4p65J-3gdjB: 12.26 4p65L-3gdjB: 12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3hhr	HUMAN GROWTH HORMONE (Homo sapiens)	PF00103 (Hormone_1)	5	LEU A 117 HIS A  21 LEU A  20 ALA A  17 LEU A 177	None	1.12A	4p65C-3hhrA: undetectable 4p65D-3hhrA: undetectable 4p65J-3hhrA: undetectable 4p65L-3hhrA: undetectable	4p65C-3hhrA: 7.89 4p65D-3hhrA: 10.29 4p65J-3hhrA: 10.29 4p65L-3hhrA: 10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3i9v	NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 (Thermus thermophilus)	PF00384 (Molybdopterin) PF01568 (Molydop_binding) PF04879 (Molybdop_Fe4S4) PF10588 (NADH-G_4Fe-4S_3) PF13510 (Fer2_4)	5	LEU 3 641 LEU 3 360 ALA 3 357 LEU 3 345 VAL 3 341	None	1.09A	4p65C-3i9v3: undetectable 4p65D-3i9v3: undetectable 4p65J-3i9v3: undetectable 4p65L-3i9v3: undetectable	4p65C-3i9v3: 2.44 4p65D-3i9v3: 3.60 4p65J-3i9v3: 3.60 4p65L-3i9v3: 3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3igh	UNCHARACTERIZED METAL-DEPENDENT HYDROLASE (Pyrococcus horikoshii)	PF07969 (Amidohydro_3)	5	LEU X 285 ALA X 290 LEU X 292 VAL X 359 LEU X 337	None	1.13A	4p65C-3ighX: undetectable 4p65D-3ighX: undetectable 4p65J-3ighX: undetectable 4p65L-3ighX: undetectable	4p65C-3ighX: 4.64 4p65D-3ighX: 6.05 4p65J-3ighX: 6.05 4p65L-3ighX: 6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3mdy	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B (Homo sapiens)	PF07714 (Pkinase_Tyr) PF08515 (TGF_beta_GS)	5	LEU A 491 LEU A 302 ALA A 305 LEU A 407 LEU A 463	None	1.07A	4p65C-3mdyA: undetectable 4p65D-3mdyA: undetectable 4p65J-3mdyA: undetectable 4p65L-3mdyA: undetectable	4p65C-3mdyA: 5.65 4p65D-3mdyA: 5.97 4p65J-3mdyA: 5.97 4p65L-3mdyA: 5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ngw	MOLYBDOPTERIN-GUANIN E DINUCLEOTIDE BIOSYNTHESIS PROTEIN A (MOBA) (Archaeoglobus fulgidus)	PF12804 (NTP_transf_3)	5	LEU A 138 CYH A  86 LEU A  80 ALA A 134 VAL A  88	None	1.16A	4p65C-3ngwA: undetectable 4p65D-3ngwA: undetectable 4p65J-3ngwA: undetectable 4p65L-3ngwA: undetectable	4p65C-3ngwA: 16.13 4p65D-3ngwA: 12.90 4p65J-3ngwA: 12.90 4p65L-3ngwA: 12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3no3	GLYCEROPHOSPHODIESTE R PHOSPHODIESTERASE (Parabacteroides distasonis)	PF03009 (GDPD)	5	LEU A 120 LEU A 109 ALA A 112 LEU A  47 VAL A  62	None	1.06A	4p65C-3no3A: undetectable 4p65D-3no3A: undetectable 4p65J-3no3A: undetectable 4p65L-3no3A: undetectable	4p65C-3no3A: 8.18 4p65D-3no3A: 7.98 4p65J-3no3A: 7.98 4p65L-3no3A: 7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3og9	PROTEIN YAHD A COPPER INDUCIBLE HYDROLASE (Lactococcus lactis)	PF01738 (DLH)	5	LEU A 114 HIS A 131 ALA A 129 LEU A 151 VAL A 160	None	1.07A	4p65C-3og9A: undetectable 4p65D-3og9A: undetectable 4p65J-3og9A: undetectable 4p65L-3og9A: undetectable	4p65C-3og9A: 5.77 4p65D-3og9A: 9.60 4p65J-3og9A: 9.60 4p65L-3og9A: 9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3p0w	MANDELATE RACEMASE/MUCONATE LACTONIZING PROTEIN (Ralstonia pickettii)	PF13378 (MR_MLE_C)	5	LEU A 136 ALA A 135 LEU A  43 VAL A  68 LEU A  65	None	1.15A	4p65C-3p0wA: undetectable 4p65D-3p0wA: undetectable 4p65J-3p0wA: undetectable 4p65L-3p0wA: undetectable	4p65C-3p0wA: 4.03 4p65D-3p0wA: 11.32 4p65J-3p0wA: 11.32 4p65L-3p0wA: 11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3pdi	NITROGENASE MOFE COFACTOR BIOSYNTHESIS PROTEIN NIFN (Azotobacter vinelandii)	PF00148 (Oxidored_nitro)	5	LEU B 332 ALA B 314 LEU B 431 VAL B 423 LEU B 424	None	0.91A	4p65C-3pdiB: undetectable 4p65D-3pdiB: undetectable 4p65J-3pdiB: undetectable 4p65L-3pdiB: undetectable	4p65C-3pdiB: 7.61 4p65D-3pdiB: 6.50 4p65J-3pdiB: 6.50 4p65L-3pdiB: 6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3sdi	PROTEASOME COMPONENT PRE5 (Saccharomyces cerevisiae)	PF00227 (Proteasome) PF10584 (Proteasome_A_N)	5	CYH E  70 LEU E  92 ALA E 112 LEU E 107 HIS E  73	None	0.94A	4p65C-3sdiE: undetectable 4p65D-3sdiE: undetectable 4p65J-3sdiE: undetectable 4p65L-3sdiE: undetectable	4p65C-3sdiE: 13.95 4p65D-3sdiE: 9.91 4p65J-3sdiE: 9.91 4p65L-3sdiE: 9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3slk	POLYKETIDE SYNTHASE EXTENDER MODULE 2 (Saccharopolyspora spinosa)	PF08240 (ADH_N) PF08659 (KR) PF13602 (ADH_zinc_N_2)	5	LEU A  13 ALA A 149 LEU A 163 VAL A 136 LEU A  97	None	1.07A	4p65C-3slkA: undetectable 4p65D-3slkA: undetectable 4p65J-3slkA: undetectable 4p65L-3slkA: undetectable	4p65C-3slkA: 2.26 4p65D-3slkA: 3.66 4p65J-3slkA: 3.66 4p65L-3slkA: 3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3tz6	ASPARTATE-SEMIALDEHY DE DEHYDROGENASE (Mycobacterium tuberculosis)	PF01118 (Semialdhyde_dh) PF02774 (Semialdhyde_dhC)	5	LEU A 142 LEU A 277 ALA A 273 LEU A 317 VAL A 321	None	1.02A	4p65C-3tz6A: undetectable 4p65D-3tz6A: undetectable 4p65J-3tz6A: undetectable 4p65L-3tz6A: undetectable	4p65C-3tz6A: 6.54 4p65D-3tz6A: 7.47 4p65J-3tz6A: 7.47 4p65L-3tz6A: 7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3uet	ALPHA-1,3/4-FUCOSIDA SE (Bifidobacterium longum)	PF01120 (Alpha_L_fucos)	5	LEU A 373 ALA A 473 LEU A 395 VAL A 461 LEU A 421	None	1.10A	4p65C-3uetA: undetectable 4p65D-3uetA: undetectable 4p65J-3uetA: undetectable 4p65L-3uetA: undetectable	4p65C-3uetA: 4.32 4p65D-3uetA: 4.06 4p65J-3uetA: 4.06 4p65L-3uetA: 4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3wqf	D-THREO-3-HYDROXYASP ARTATE DEHYDRATASE (Delftia sp. HT23)	PF01168 (Ala_racemase_N) PF14031 (D-ser_dehydrat)	5	LEU A  67 CYH A 103 LEU A  98 ALA A  95 LEU A 107	None	1.10A	4p65C-3wqfA: undetectable 4p65D-3wqfA: undetectable 4p65J-3wqfA: undetectable 4p65L-3wqfA: undetectable	4p65C-3wqfA: 3.85 4p65D-3wqfA: 7.69 4p65J-3wqfA: 7.69 4p65L-3wqfA: 7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4dkb	DEOXYURIDINE TRIPHOSPHATASE (Trypanosoma brucei)	PF08761 (dUTPase_2)	6	LEU A 238 HIS A 209 LEU A 211 ALA A 207 HIS A  82 LEU A  24	None None None None DUN  A 303 (-3.7A) DUN  A 303 (-4.3A)	1.40A	4p65C-4dkbA: undetectable 4p65D-4dkbA: undetectable 4p65J-4dkbA: undetectable 4p65L-4dkbA: undetectable	4p65C-4dkbA: 5.04 4p65D-4dkbA: 7.53 4p65J-4dkbA: 7.53 4p65L-4dkbA: 7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4g3a	CLIP-ASSOCIATING PROTEIN (Drosophila melanogaster)	PF12348 (CLASP_N)	5	LEU A  31 LEU A  35 ALA A  72 LEU A  54 LEU A  80	None	1.10A	4p65C-4g3aA: undetectable 4p65D-4g3aA: undetectable 4p65J-4g3aA: undetectable 4p65L-4g3aA: undetectable	4p65C-4g3aA: 7.98 4p65D-4g3aA: 9.27 4p65J-4g3aA: 9.27 4p65L-4g3aA: 9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4g8z	DIHYDROFOLATE REDUCTASE (Pneumocystis jirovecii)	PF00186 (DHFR_1)	5	LEU X  98 LEU X   7 ALA X 132 LEU X 128 VAL X  54	None None None NDP  X 302 (-4.0A) None	1.15A	4p65C-4g8zX: undetectable 4p65D-4g8zX: undetectable 4p65J-4g8zX: undetectable 4p65L-4g8zX: undetectable	4p65C-4g8zX: 7.41 4p65D-4g8zX: 10.30 4p65J-4g8zX: 10.30 4p65L-4g8zX: 10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4h05	AMINOGLYCOSIDE-O-PHO SPHOTRANSFERASE VIII (Streptomyces rimosus)	PF01636 (APH)	5	LEU A 202 LEU A  62 LEU A 113 VAL A 180 LEU A 120	None	1.14A	4p65C-4h05A: undetectable 4p65D-4h05A: undetectable 4p65J-4h05A: undetectable 4p65L-4h05A: undetectable	4p65C-4h05A: 4.95 4p65D-4h05A: 8.44 4p65J-4h05A: 8.44 4p65L-4h05A: 8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ivn	TRANSCRIPTIONAL REGULATOR (Vibrio vulnificus)	PF01380 (SIS) PF01418 (HTH_6)	5	LEU A   8 LEU A  30 ALA A  33 LEU A  74 LEU A  58	None	1.14A	4p65C-4ivnA: undetectable 4p65D-4ivnA: undetectable 4p65J-4ivnA: undetectable 4p65L-4ivnA: undetectable	4p65C-4ivnA: 5.78 4p65D-4ivnA: 8.05 4p65J-4ivnA: 8.05 4p65L-4ivnA: 8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4kng	E3 UBIQUITIN-PROTEIN LIGASE RNF43 (Homo sapiens)	no annotation	5	LEU E 122 LEU E 151 ALA E 147 LEU E 109 VAL E 137	None	1.16A	4p65C-4kngE: undetectable 4p65D-4kngE: undetectable 4p65J-4kngE: undetectable 4p65L-4kngE: undetectable	4p65C-4kngE: 10.14 4p65D-4kngE: 11.25 4p65J-4kngE: 11.25 4p65L-4kngE: 11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4m5d	RIBOSOMAL RNA-PROCESSING PROTEIN 7 (Saccharomyces cerevisiae)	PF12923 (RRP7)	5	LEU B  55 CYH B 137 ALA B  39 VAL B  71 LEU B  74	None	1.16A	4p65C-4m5dB: undetectable 4p65D-4m5dB: undetectable 4p65J-4m5dB: undetectable 4p65L-4m5dB: undetectable	4p65C-4m5dB: 5.41 4p65D-4m5dB: 8.73 4p65J-4m5dB: 8.73 4p65L-4m5dB: 8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4mni	TRAP DICARBOXYLATE TRANSPORTER-DCTP SUBUNIT (Polaromonas sp. JS666)	PF03480 (DctP)	5	LEU A 235 LEU A  34 LEU A 260 VAL A  45 LEU A  49	None	1.11A	4p65C-4mniA: undetectable 4p65D-4mniA: undetectable 4p65J-4mniA: undetectable 4p65L-4mniA: undetectable	4p65C-4mniA: 6.49 4p65D-4mniA: 5.69 4p65J-4mniA: 5.69 4p65L-4mniA: 5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4n6f	PUTATIVE THIOSUGAR SYNTHASE (Amycolatopsis orientalis)	PF05690 (ThiG)	5	LEU A 132 LEU A  94 ALA A  97 LEU A 109 VAL A 113	None	1.09A	4p65C-4n6fA: undetectable 4p65D-4n6fA: undetectable 4p65J-4n6fA: undetectable 4p65L-4n6fA: undetectable	4p65C-4n6fA: 4.58 4p65D-4n6fA: 7.03 4p65J-4n6fA: 7.03 4p65L-4n6fA: 7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4nph	PROBABLE SECRETION SYSTEM APPARATUS ATP SYNTHASE SSAN (Salmonella enterica)	PF00006 (ATP-synt_ab)	5	LEU A 230 LEU A 254 ALA A 251 LEU A 249 LEU A 325	None	0.86A	4p65C-4nphA: undetectable 4p65D-4nphA: undetectable 4p65J-4nphA: undetectable 4p65L-4nphA: undetectable	4p65C-4nphA: 5.99 4p65D-4nphA: 8.98 4p65J-4nphA: 8.98 4p65L-4nphA: 8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4o89	RNA 3'-TERMINAL PHOSPHATE CYCLASE (Pyrococcus horikoshii)	PF01137 (RTC) PF05189 (RTC_insert)	5	CYH A 279 LEU A 245 ALA A 139 LEU A 284 LEU A 292	None	1.12A	4p65C-4o89A: undetectable 4p65D-4o89A: undetectable 4p65J-4o89A: undetectable 4p65L-4o89A: undetectable	4p65C-4o89A: 8.28 4p65D-4o89A: 7.54 4p65J-4o89A: 7.54 4p65L-4o89A: 7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ppz	SUCCINYL-DIAMINOPIME LATE DESUCCINYLASE (Neisseria meningitidis)	PF01546 (Peptidase_M20) PF07687 (M20_dimer)	5	LEU A 216 LEU A 213 ALA A 212 LEU A 277 LEU A 252	None	0.95A	4p65C-4ppzA: undetectable 4p65D-4ppzA: undetectable 4p65J-4ppzA: undetectable 4p65L-4ppzA: undetectable	4p65C-4ppzA: 4.92 4p65D-4ppzA: 7.89 4p65J-4ppzA: 7.89 4p65L-4ppzA: 7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4rld	ASPARTIC PROTEASE BLA G 2 (Blattella germanica)	PF00026 (Asp)	5	LEU A 107 ALA A  49 LEU A  53 VAL A  30 LEU A 115	None	1.03A	4p65C-4rldA: undetectable 4p65D-4rldA: undetectable 4p65J-4rldA: undetectable 4p65L-4rldA: undetectable	4p65C-4rldA: 5.36 4p65D-4rldA: 9.95 4p65J-4rldA: 9.95 4p65L-4rldA: 9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4rlv	ANKYRIN-1, ANKYRIN-2 (Homo sapiens; Mus musculus)	PF00023 (Ank) PF12796 (Ank_2) PF13637 (Ank_4) PF13857 (Ank_5)	5	CYH A2375 ALA A2368 LEU A2384 VAL A2413 LEU A2417	None	1.16A	4p65C-4rlvA: undetectable 4p65D-4rlvA: undetectable 4p65J-4rlvA: undetectable 4p65L-4rlvA: undetectable	4p65C-4rlvA: 5.32 4p65D-4rlvA: 4.73 4p65J-4rlvA: 4.73 4p65L-4rlvA: 4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4rlv	ANKYRIN-1, ANKYRIN-2 (Homo sapiens; Mus musculus)	PF00023 (Ank) PF12796 (Ank_2) PF13637 (Ank_4) PF13857 (Ank_5)	5	LEU A2171 ALA A2195 LEU A2211 VAL A2248 LEU A2252	None	1.14A	4p65C-4rlvA: undetectable 4p65D-4rlvA: undetectable 4p65J-4rlvA: undetectable 4p65L-4rlvA: undetectable	4p65C-4rlvA: 5.32 4p65D-4rlvA: 4.73 4p65J-4rlvA: 4.73 4p65L-4rlvA: 4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4wj7	MALCAVERNIN (Homo sapiens)	no annotation	5	LEU A  70 HIS A 151 LEU A 152 ALA A 199 LEU A 105	None	1.16A	4p65C-4wj7A: undetectable 4p65D-4wj7A: undetectable 4p65J-4wj7A: undetectable 4p65L-4wj7A: undetectable	4p65C-4wj7A: 6.75 4p65D-4wj7A: 14.07 4p65J-4wj7A: 14.07 4p65L-4wj7A: 14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4wja	UNCHARACTERIZED PROTEIN C9ORF142 (Homo sapiens)	PF15384 (PAXX)	5	CYH A  22 LEU A  87 ALA A  94 LEU A  89 LEU A  47	None	1.04A	4p65C-4wjaA: undetectable 4p65D-4wjaA: undetectable 4p65J-4wjaA: undetectable 4p65L-4wjaA: undetectable	4p65C-4wjaA: 11.46 4p65D-4wjaA: 11.18 4p65J-4wjaA: 11.18 4p65L-4wjaA: 11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4wjl	INACTIVE DIPEPTIDYL PEPTIDASE 10 (Homo sapiens)	PF00326 (Peptidase_S9) PF00930 (DPPIV_N)	5	HIS A 741 LEU A 742 ALA A 745 VAL A 707 LEU A 708	None	0.74A	4p65C-4wjlA: undetectable 4p65D-4wjlA: undetectable 4p65J-4wjlA: undetectable 4p65L-4wjlA: undetectable	4p65C-4wjlA: 2.79 4p65D-4wjlA: 3.60 4p65J-4wjlA: 3.60 4p65L-4wjlA: 3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4xef	PROTEIN-TYROSINE KINASE 2-BETA 20-MER PEPTIDE CONTAINING LD1 MOTIF OF LEUPAXIN (Homo sapiens; Homo sapiens)	PF03623 (Focal_AT) no annotation	5	LEU A 953 HIS A 981 LEU A 983 ALA A 979 LEU B  11	None	1.07A	4p65C-4xefA: undetectable 4p65D-4xefA: undetectable 4p65J-4xefA: undetectable 4p65L-4xefA: undetectable	4p65C-4xefA: 6.47 4p65D-4xefA: 8.63 4p65J-4xefA: 8.63 4p65L-4xefA: 8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4xev	FUSION PROTEIN OF PROTEIN-TYROSINE KINASE 2-BETA FAT DOMAIN AND LEUPAXIN LD1 MOTIF (Homo sapiens)	PF03623 (Focal_AT)	5	LEU A 953 HIS A 981 LEU A 983 ALA A 979 LEU A2011	None	1.14A	4p65C-4xevA: undetectable 4p65D-4xevA: undetectable 4p65J-4xevA: undetectable 4p65L-4xevA: undetectable	4p65C-4xevA: 9.28 4p65D-4xevA: 9.26 4p65J-4xevA: 9.26 4p65L-4xevA: 9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4xpz	RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE (Schizosaccharomyces pombe)	PF03031 (NIF) PF12738 (PTCB-BRCT)	5	LEU A 429 LEU A 434 ALA A 455 LEU A 504 VAL A 495	None	1.13A	4p65C-4xpzA: undetectable 4p65D-4xpzA: undetectable 4p65J-4xpzA: undetectable 4p65L-4xpzA: undetectable	4p65C-4xpzA: 4.35 4p65D-4xpzA: 5.85 4p65J-4xpzA: 5.85 4p65L-4xpzA: 5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4yii	UBIQUITIN-CONJUGATIN G ENZYME E2 C (Homo sapiens)	PF00179 (UQ_con)	5	LEU U 132 LEU U  83 ALA U  52 LEU U  42 LEU U  35	None	1.02A	4p65C-4yiiU: undetectable 4p65D-4yiiU: undetectable 4p65J-4yiiU: undetectable 4p65L-4yiiU: undetectable	4p65C-4yiiU: 8.06 4p65D-4yiiU: 11.03 4p65J-4yiiU: 11.03 4p65L-4yiiU: 11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ysw	XANTHINE DEHYDROGENASE/OXIDAS E (Rattus norvegicus)	PF00111 (Fer2) PF00941 (FAD_binding_5) PF01315 (Ald_Xan_dh_C) PF01799 (Fer2_2) PF02738 (Ald_Xan_dh_C2) PF03450 (CO_deh_flav_C)	5	HIS A 817 ALA A 815 LEU A 635 VAL A 776 LEU A 780	None	1.11A	4p65C-4yswA: undetectable 4p65D-4yswA: undetectable 4p65J-4yswA: undetectable 4p65L-4yswA: undetectable	4p65C-4yswA: 1.48 4p65D-4yswA: 2.17 4p65J-4yswA: 2.17 4p65L-4yswA: 2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4yu5	IMMUNE INHIBITOR A, METALLOPROTEASE (Bacillus cereus)	PF05547 (Peptidase_M6)	5	LEU A 169 HIS A 275 LEU A 274 ALA A 277 LEU A 241	None	1.13A	4p65C-4yu5A: undetectable 4p65D-4yu5A: undetectable 4p65J-4yu5A: undetectable 4p65L-4yu5A: undetectable	4p65C-4yu5A: 2.58 4p65D-4yu5A: 3.94 4p65J-4yu5A: 3.94 4p65L-4yu5A: 3.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5a46	FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B (Homo sapiens)	PF07714 (Pkinase_Tyr)	5	CYH A 603 LEU A 569 LEU A 573 ALA A 626 LEU A 689	None	1.16A	4p65C-5a46A: undetectable 4p65D-5a46A: undetectable 4p65J-5a46A: undetectable 4p65L-5a46A: undetectable	4p65C-5a46A: 3.95 4p65D-5a46A: 6.77 4p65J-5a46A: 6.77 4p65L-5a46A: 6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5cb2	PROTEIN SEY1 (Candida albicans)	PF05879 (RHD3)	5	LEU A 273 LEU A  78 VAL A 202 HIS A 250 LEU A 252	None	1.09A	4p65C-5cb2A: undetectable 4p65D-5cb2A: undetectable 4p65J-5cb2A: undetectable 4p65L-5cb2A: undetectable	4p65C-5cb2A: 4.32 4p65D-5cb2A: 4.01 4p65J-5cb2A: 4.01 4p65L-5cb2A: 4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ce5	TRIACYLGLYCEROL LIPASE (Geobacillus thermocatenulatus)	no annotation	5	LEU A  71 LEU A 123 ALA A  67 LEU A  52 VAL A 159	None	1.10A	4p65C-5ce5A: undetectable 4p65D-5ce5A: undetectable 4p65J-5ce5A: undetectable 4p65L-5ce5A: undetectable	4p65C-5ce5A: 4.31 4p65D-5ce5A: 7.23 4p65J-5ce5A: 7.23 4p65L-5ce5A: 7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ckm	MANNAN-BINDING LECTIN SERINE PEPTIDASE 2 (Rattus norvegicus)	PF00431 (CUB) PF07645 (EGF_CA)	5	LEU A  94 LEU A  40 LEU A  67 VAL A  58 LEU A  70	None	1.03A	4p65C-5ckmA: undetectable 4p65D-5ckmA: undetectable 4p65J-5ckmA: undetectable 4p65L-5ckmA: undetectable	4p65C-5ckmA: 6.28 4p65D-5ckmA: 6.27 4p65J-5ckmA: 6.27 4p65L-5ckmA: 6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5cof	UNCHARACTERIZED PROTEIN (Escherichia coli)	PF08020 (DUF1706)	5	LEU A 160 ALA A 156 LEU A  52 VAL A 108 LEU A 111	None	1.12A	4p65C-5cofA: undetectable 4p65D-5cofA: undetectable 4p65J-5cofA: undetectable 4p65L-5cofA: undetectable	4p65C-5cofA: 7.69 4p65D-5cofA: 12.77 4p65J-5cofA: 12.77 4p65L-5cofA: 12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5czz	CRISPR-ASSOCIATED ENDONUCLEASE CAS9 (Staphylococcus aureus)	PF13395 (HNH_4) PF16592 (Cas9_REC)	5	LEU A 183 LEU A 109 LEU A 100 HIS A 191 LEU A  76	None	1.11A	4p65C-5czzA: undetectable 4p65D-5czzA: undetectable 4p65J-5czzA: undetectable 4p65L-5czzA: undetectable	4p65C-5czzA: 2.01 4p65D-5czzA: 4.05 4p65J-5czzA: 4.05 4p65L-5czzA: 4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5gvi	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30 (Danio rerio)	PF00443 (UCH)	5	LEU A 119 LEU A 139 ALA A 136 LEU A  66 LEU A 161	None	1.14A	4p65C-5gviA: undetectable 4p65D-5gviA: undetectable 4p65J-5gviA: undetectable 4p65L-5gviA: undetectable	4p65C-5gviA: 5.17 4p65D-5gviA: 5.74 4p65J-5gviA: 5.74 4p65L-5gviA: 5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5hjr	NEUTRAL ALPHA-GLUCOSIDASE AB (Mus musculus)	PF01055 (Glyco_hydro_31) PF13802 (Gal_mutarotas_2)	5	HIS A 477 LEU A 475 ALA A 479 VAL A 431 LEU A 432	None	1.04A	4p65C-5hjrA: undetectable 4p65D-5hjrA: undetectable 4p65J-5hjrA: undetectable 4p65L-5hjrA: undetectable	4p65C-5hjrA: 2.59 4p65D-5hjrA: 3.31 4p65J-5hjrA: 3.31 4p65L-5hjrA: 3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ja1	ENTEROBACTIN SYNTHASE COMPONENT F (Escherichia coli)	PF00501 (AMP-binding) PF00550 (PP-binding) PF00668 (Condensation) PF00975 (Thioesterase) PF13193 (AMP-binding_C)	5	LEU A1139 LEU A1224 ALA A1220 VAL A1186 LEU A1187	None	1.09A	4p65C-5ja1A: undetectable 4p65D-5ja1A: undetectable 4p65J-5ja1A: undetectable 4p65L-5ja1A: undetectable	4p65C-5ja1A: 1.55 4p65D-5ja1A: 2.38 4p65J-5ja1A: 2.38 4p65L-5ja1A: 2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5jpe	SERINE/THREONINE-PRO TEIN PHOSPHATASE (Candida albicans)	PF00149 (Metallophos) PF16891 (STPPase_N)	5	CYH A 456 CYH A 336 ALA A 331 VAL A 226 LEU A 253	None	1.15A	4p65C-5jpeA: undetectable 4p65D-5jpeA: undetectable 4p65J-5jpeA: undetectable 4p65L-5jpeA: undetectable	4p65C-5jpeA: 6.16 4p65D-5jpeA: 7.75 4p65J-5jpeA: 7.75 4p65L-5jpeA: 7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5k7f	TRANSCRIPTIONAL REGULATOR, TETR FAMILY (Myxococcus xanthus)	PF00440 (TetR_N)	5	LEU A  90 LEU A 138 ALA A 141 VAL A  76 LEU A  77	None	0.88A	4p65C-5k7fA: undetectable 4p65D-5k7fA: undetectable 4p65J-5k7fA: undetectable 4p65L-5k7fA: undetectable	4p65C-5k7fA: 14.00 4p65D-5k7fA: 9.38 4p65J-5k7fA: 9.38 4p65L-5k7fA: 9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ool	39S RIBOSOMAL PROTEIN L37, MITOCHONDRIAL (Homo sapiens)	PF07147 (PDCD9)	5	LEU 5 198 HIS 5 420 LEU 5 419 ALA 5 422 HIS 5 289	None	1.05A	4p65C-5ool5: undetectable 4p65D-5ool5: undetectable 4p65J-5ool5: undetectable 4p65L-5ool5: undetectable	4p65C-5ool5: 4.70 4p65D-5ool5: 6.42 4p65J-5ool5: 6.42 4p65L-5ool5: 6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5t8y	EPOXYQUEUOSINE REDUCTASE (Bacillus subtilis)	PF08331 (DUF1730) PF13484 (Fer4_16) PF13646 (HEAT_2)	5	CYH A 156 LEU A 209 CYH A 194 LEU A 203 ALA A 202	B12  A 503 ( 4.5A) B12  A 503 ( 3.9A) SF4  A 501 (-2.2A) SF4  A 502 ( 4.6A) SF4  A 502 ( 3.9A)	1.06A	4p65C-5t8yA: undetectable 4p65D-5t8yA: undetectable 4p65J-5t8yA: undetectable 4p65L-5t8yA: undetectable	4p65C-5t8yA: 3.62 4p65D-5t8yA: 5.66 4p65J-5t8yA: 5.66 4p65L-5t8yA: 5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5u4z	REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION (Citrus sinensis)	PF09174 (Maf1)	5	LEU A 145 LEU A 141 ALA A 144 LEU A   9 LEU A  16	None	1.08A	4p65C-5u4zA: undetectable 4p65D-5u4zA: undetectable 4p65J-5u4zA: undetectable 4p65L-5u4zA: undetectable	4p65C-5u4zA: 5.70 4p65D-5u4zA: 7.94 4p65J-5u4zA: 7.94 4p65L-5u4zA: 7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ux2	ALDEHYDE DECARBONYLASE (Synechococcus sp. RS9917)	no annotation	5	CYH A 110 LEU A 106 HIS A 141 LEU A 142 ALA A 145	None None FE  A 301 (-3.5A) None None	1.13A	4p65C-5ux2A: undetectable 4p65D-5ux2A: undetectable 4p65J-5ux2A: undetectable 4p65L-5ux2A: undetectable	4p65C-5ux2A: undetectable 4p65D-5ux2A: undetectable 4p65J-5ux2A: undetectable 4p65L-5ux2A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5uxb	MACROLIDE 2'-PHOSPHOTRANSFERAS E MPHH (Brachybacterium faecium)	PF01636 (APH)	5	LEU A 257 HIS A 230 LEU A 243 VAL A 127 LEU A 123	None	0.89A	4p65C-5uxbA: undetectable 4p65D-5uxbA: undetectable 4p65J-5uxbA: undetectable 4p65L-5uxbA: undetectable	4p65C-5uxbA: 8.55 4p65D-5uxbA: 8.64 4p65J-5uxbA: 8.64 4p65L-5uxbA: 8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5vfr	PROTEASOME SUBUNIT ALPHA TYPE-4 (Homo sapiens)	no annotation	5	LEU I  35 LEU I  44 ALA I  46 LEU I 197 LEU I 236	None	1.08A	4p65C-5vfrI: undetectable 4p65D-5vfrI: undetectable 4p65J-5vfrI: undetectable 4p65L-5vfrI: undetectable	4p65C-5vfrI: undetectable 4p65D-5vfrI: undetectable 4p65J-5vfrI: undetectable 4p65L-5vfrI: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5vpq	BETA-LACTAMASE (Paraburkholderia phymatum)	PF13354 (Beta-lactamase2)	5	LEU A 182 LEU A  63 ALA A  66 LEU A 197 VAL A 237	None	1.11A	4p65C-5vpqA: undetectable 4p65D-5vpqA: undetectable 4p65J-5vpqA: undetectable 4p65L-5vpqA: undetectable	4p65C-5vpqA: 5.35 4p65D-5vpqA: 6.41 4p65J-5vpqA: 6.41 4p65L-5vpqA: 6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5w19	TRYPTOPHANASE (Proteus vulgaris)	no annotation	5	LEU A 437 LEU A 380 ALA A 379 LEU A 444 VAL A 357	None	1.08A	4p65C-5w19A: undetectable 4p65D-5w19A: undetectable 4p65J-5w19A: undetectable 4p65L-5w19A: undetectable	4p65C-5w19A: undetectable 4p65D-5w19A: undetectable 4p65J-5w19A: undetectable 4p65L-5w19A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5y4d	ANKYRIN-1,ANKYRIN-2, ANKYRIN-2 (Homo sapiens; Mus musculus)	PF00023 (Ank) PF12796 (Ank_2) PF13637 (Ank_4)	5	LEU A2171 ALA A2195 LEU A2211 VAL A2248 LEU A2252	None	1.12A	4p65C-5y4dA: undetectable 4p65D-5y4dA: undetectable 4p65J-5y4dA: undetectable 4p65L-5y4dA: undetectable	4p65C-5y4dA: 4.95 4p65D-5y4dA: 4.26 4p65J-5y4dA: 4.26 4p65L-5y4dA: 4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6cn7	AEROBACTIN SYNTHASE IUCC (Klebsiella pneumoniae)	no annotation	5	LEU A 548 LEU A  21 LEU A  78 VAL A  84 LEU A  41	None	1.11A	4p65C-6cn7A: undetectable 4p65D-6cn7A: undetectable 4p65J-6cn7A: undetectable 4p65L-6cn7A: undetectable	4p65C-6cn7A: undetectable 4p65D-6cn7A: undetectable 4p65J-6cn7A: undetectable 4p65L-6cn7A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6grw	- (-)	no annotation	5	LEU A 190 ALA A  98 LEU A  94 VAL A 147 HIS A 148	None	1.14A	4p65C-6grwA: undetectable 4p65D-6grwA: undetectable 4p65J-6grwA: undetectable 4p65L-6grwA: undetectable	4p65C-6grwA: undetectable 4p65D-6grwA: undetectable 4p65J-6grwA: undetectable 4p65L-6grwA: undetectable