SIMILAR PATTERNS OF AMINO ACIDS FOR 4OTY_B_LURB705_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b3b | PROTEIN (GLUTAMATEDEHYDROGENASE) (Thermotogamaritima) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | VAL A 95LEU A 370VAL A 345GLY A 343ALA A 342 | None | 1.06A | 4otyB-1b3bA:0.0 | 4otyB-1b3bA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bvu | PROTEIN (GLUTAMATEDEHYDROGENASE) (Thermococcuslitoralis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | VAL A 95LEU A 372VAL A 347GLY A 345ALA A 344 | None | 1.01A | 4otyB-1bvuA:undetectable | 4otyB-1bvuA:20.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ebv | PROSTAGLANDIN H2SYNTHASE (Ovis aries) |
PF00008(EGF)PF03098(An_peroxidase) | 8 | VAL A 349LEU A 352SER A 353TYR A 355LEU A 384GLY A 526ALA A 527LEU A 531 | SCL A 700 ( 4.6A)SCL A 700 ( 4.8A)NoneSCL A 700 (-4.3A)NoneSCL A 700 ( 4.0A)SCL A 700 (-2.9A)OAS A 530 (-4.1A) | 0.62A | 4otyB-1ebvA:30.6 | 4otyB-1ebvA:64.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ebv | PROSTAGLANDIN H2SYNTHASE (Ovis aries) |
PF00008(EGF)PF03098(An_peroxidase) | 9 | VAL A 349LEU A 352SER A 353TYR A 355TYR A 385TRP A 387GLY A 526ALA A 527LEU A 531 | SCL A 700 ( 4.6A)SCL A 700 ( 4.8A)NoneSCL A 700 (-4.3A)NoneNoneSCL A 700 ( 4.0A)SCL A 700 (-2.9A)OAS A 530 (-4.1A) | 0.35A | 4otyB-1ebvA:30.6 | 4otyB-1ebvA:64.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gtm | GLUTAMATEDEHYDROGENASE (Pyrococcusfuriosus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | VAL A 95LEU A 373VAL A 348GLY A 346ALA A 345 | None | 1.09A | 4otyB-1gtmA:1.1 | 4otyB-1gtmA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h4l | CELL DIVISIONPROTEIN KINASE 5 (Homo sapiens) |
PF00069(Pkinase) | 5 | LEU A 267GLY A 189ALA A 188SER A 187LEU A 127 | None | 1.04A | 4otyB-1h4lA:undetectable | 4otyB-1h4lA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ia5 | POLYGALACTURONASE (Aspergillusaculeatus) |
PF00295(Glyco_hydro_28) | 6 | VAL A 26LEU A 27SER A 28LEU A 120GLY A 78ALA A 79 | None | 1.43A | 4otyB-1ia5A:0.0 | 4otyB-1ia5A:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jy1 | TYROSYL-DNAPHOSPHODIESTERASE (Homo sapiens) |
PF06087(Tyr-DNA_phospho) | 5 | VAL A 227TYR A 537ALA A 332SER A 334LEU A 335 | None | 0.96A | 4otyB-1jy1A:0.0 | 4otyB-1jy1A:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mt5 | FATTY-ACID AMIDEHYDROLASE (Rattusnorvegicus) |
PF01425(Amidase) | 5 | VAL A 495TYR A 335LEU A 447GLY A 378ALA A 377 | MAY A 600 (-4.8A)NoneNoneNoneMAY A 600 (-3.7A) | 1.07A | 4otyB-1mt5A:0.0 | 4otyB-1mt5A:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pl0 | BIFUNCTIONAL PURINEBIOSYNTHESIS PROTEINPURH (Homo sapiens) |
PF01808(AICARFT_IMPCHas)PF02142(MGS) | 5 | VAL A 99LEU A 8LEU A 68GLY A 127LEU A 132 | NoneNoneXMP A 901 (-4.1A)XMP A 901 (-3.4A)None | 1.02A | 4otyB-1pl0A:undetectable | 4otyB-1pl0A:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1suj | CONE ARRESTIN (Ambystomatigrinum) |
PF00339(Arrestin_N)PF02752(Arrestin_C) | 5 | LEU A 105LEU A 21VAL A 40GLY A 38LEU A 94 | None | 1.05A | 4otyB-1sujA:undetectable | 4otyB-1sujA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1umf | CHORISMATE SYNTHASE (Helicobacterpylori) |
PF01264(Chorismate_synt) | 5 | LEU A 341VAL A 133GLY A 136ALA A 137LEU A 38 | None | 0.99A | 4otyB-1umfA:undetectable | 4otyB-1umfA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vb4 | COAT PROTEIN (Sesbania mosaicvirus) |
PF00729(Viral_coat) | 5 | VAL A 155LEU A 158SER A 159GLY A 167SER A 138 | None | 1.05A | 4otyB-1vb4A:undetectable | 4otyB-1vb4A:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vkn | N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATEREDUCTASE (Thermotogamaritima) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | LEU A 74GLY A 8ALA A 9SER A 34LEU A 55 | None | 1.08A | 4otyB-1vknA:undetectable | 4otyB-1vknA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a35 | HYPOTHETICAL PROTEINPA4017 (Pseudomonasaeruginosa) |
PF08732(HIM1) | 5 | LEU A 9LEU A 73GLY A 12ALA A 13LEU A 22 | None | 1.08A | 4otyB-2a35A:undetectable | 4otyB-2a35A:16.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a4v | PEROXIREDOXIN DOT5 (Saccharomycescerevisiae) |
PF00578(AhpC-TSA) | 5 | VAL A 98LEU A 130SER A 131LEU A 162GLY A 161 | None | 1.04A | 4otyB-2a4vA:undetectable | 4otyB-2a4vA:13.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ark | FLAVODOXIN (Aquifexaeolicus) |
PF00258(Flavodoxin_1) | 5 | VAL A 6LEU A 36GLY A 25ALA A 26LEU A 158 | None | 1.00A | 4otyB-2arkA:undetectable | 4otyB-2arkA:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ch6 | N-ACETYL-D-GLUCOSAMINE KINASE (Homo sapiens) |
PF01869(BcrAD_BadFG) | 5 | LEU A 75SER A 76LEU A 318GLY A 110SER A 311 | None | 1.00A | 4otyB-2ch6A:0.1 | 4otyB-2ch6A:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ejb | PROBABLE AROMATICACID DECARBOXYLASE (Aquifexaeolicus) |
PF02441(Flavoprotein) | 5 | SER A 75LEU A 121VAL A 113GLY A 111LEU A 106 | None | 1.09A | 4otyB-2ejbA:undetectable | 4otyB-2ejbA:16.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2elc | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Thermusthermophilus) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | TYR A 238LEU A 74GLY A 290ALA A 289LEU A 285 | None | 1.07A | 4otyB-2elcA:undetectable | 4otyB-2elcA:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2exa | PENICILLIN-BINDINGPROTEIN 4 (Escherichiacoli) |
PF02113(Peptidase_S13) | 5 | LEU A 303LEU A 374GLY A 429ALA A 416SER A 415 | NoneNoneNoneNoneGOL A 502 (-2.3A) | 1.09A | 4otyB-2exaA:undetectable | 4otyB-2exaA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ftp | HYDROXYMETHYLGLUTARYL-COA LYASE (Pseudomonasaeruginosa) |
PF00682(HMGL-like) | 5 | VAL A 274LEU A 273GLY A 236ALA A 235SER A 290 | None | 1.09A | 4otyB-2ftpA:undetectable | 4otyB-2ftpA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gai | DNA TOPOISOMERASE I (Thermotogamaritima) |
PF01131(Topoisom_bac)PF01751(Toprim) | 5 | LEU A 472VAL A 168GLY A 166ALA A 165SER A 164 | None | 1.09A | 4otyB-2gaiA:0.7 | 4otyB-2gaiA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gk9 | PHOSPHATIDYLINOSITOL-4-PHOSPHATE5-KINASE, TYPE II,GAMMA (Homo sapiens) |
PF01504(PIP5K) | 5 | LEU A 126TYR A 189GLY A 54ALA A 56SER A 58 | None | 0.99A | 4otyB-2gk9A:undetectable | 4otyB-2gk9A:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ib0 | CONSERVEDHYPOTHETICAL ALANINERICH PROTEIN (Mycobacteriumtuberculosis) |
PF14530(DUF4439) | 5 | VAL A 147LEU A 148LEU A 102VAL A 104LEU A 54 | None | 0.96A | 4otyB-2ib0A:undetectable | 4otyB-2ib0A:13.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j6i | FORMATEDEHYDROGENASE ([Candida]boidinii) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | LEU A 238TYR A 194VAL A 227GLY A 171ALA A 229 | None | 1.07A | 4otyB-2j6iA:undetectable | 4otyB-2j6iA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2of3 | ZYG-9 (Caenorhabditiselegans) |
no annotation | 5 | LEU A 777LEU A 790VAL A 824ALA A 828LEU A 832 | None | 0.93A | 4otyB-2of3A:0.9 | 4otyB-2of3A:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pbl | PUTATIVEESTERASE/LIPASE/THIOESTERASE (Ruegeria sp.TM1040) |
PF07859(Abhydrolase_3) | 5 | TRP A 81GLY A 138ALA A 137SER A 136LEU A 168 | NoneNoneNoneUNL A 263 (-3.7A)None | 1.05A | 4otyB-2pblA:undetectable | 4otyB-2pblA:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ppl | PANCREATICLIPASE-RELATEDPROTEIN 1 (Homo sapiens) |
PF00151(Lipase)PF01477(PLAT) | 5 | LEU A 209VAL A 176GLY A 178ALA A 180SER A 182 | NoneNone CA A 478 ( 4.9A)NoneNone | 0.94A | 4otyB-2pplA:undetectable | 4otyB-2pplA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r7d | RIBONUCLEASE IIFAMILY PROTEIN (Deinococcusradiodurans) |
PF00773(RNB) | 5 | VAL A 120LEU A 173SER A 174GLY A 274ALA A 273 | None | 0.97A | 4otyB-2r7dA:undetectable | 4otyB-2r7dA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ru4 | ARMADILLO REPEATPROTEIN, C-TERMINALFRAGMENT, MAIIARMADILLO REPEATPROTEIN, N-TERMINALFRAGMENT, YIIM2 (syntheticconstruct) |
PF00514(Arm)PF16186(Arm_3) | 5 | SER A 110VAL B 123GLY B 127ALA B 128LEU B 132 | None | 0.99A | 4otyB-2ru4A:undetectable | 4otyB-2ru4A:11.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vos | FOLYLPOLYGLUTAMATESYNTHASE PROTEINFOLC (Mycobacteriumtuberculosis) |
PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | LEU A 103VAL A 475GLY A 478ALA A 479LEU A 483 | None | 0.92A | 4otyB-2vosA:undetectable | 4otyB-2vosA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vq0 | COAT PROTEIN (Sesbania mosaicvirus) |
PF00729(Viral_coat) | 5 | VAL A 155LEU A 158SER A 159GLY A 167SER A 138 | None | 1.05A | 4otyB-2vq0A:undetectable | 4otyB-2vq0A:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vrg | MULTIPLE COAGULATIONFACTOR DEFICIENCYPROTEIN 2 (Homo sapiens) |
PF13499(EF-hand_7) | 5 | VAL A 100LEU A 145SER A 144LEU A 74LEU A 93 | None | 1.09A | 4otyB-2vrgA:undetectable | 4otyB-2vrgA:10.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wsk | GLYCOGEN DEBRANCHINGENZYME (Escherichiacoli) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 5 | SER A 421TRP A 579GLY A 412ALA A 413LEU A 409 | None | 0.89A | 4otyB-2wskA:0.0 | 4otyB-2wskA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xec | PUTATIVE MALEATEISOMERASE (Nocardiafarcinica) |
no annotation | 5 | LEU A 158VAL A 174ALA A 178SER A 180LEU A 181 | None | 1.00A | 4otyB-2xecA:undetectable | 4otyB-2xecA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xn8 | PUTATIVE CYTOCHROMEP450 125 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | VAL A 313LEU A 415VAL A 267GLY A 269ALA A 268 | HEM A1434 ( 4.9A)NoneNoneHEM A1434 (-3.3A)HEM A1434 (-3.5A) | 0.99A | 4otyB-2xn8A:undetectable | 4otyB-2xn8A:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ylz | PHENYLACETONEMONOOXYGENASE (Thermobifidafusca) |
PF13738(Pyr_redox_3) | 5 | LEU A 146VAL A 21GLY A 23ALA A 149SER A 150 | NoneNoneFAD A 700 (-3.3A)NoneFAD A 700 (-4.9A) | 1.07A | 4otyB-2ylzA:undetectable | 4otyB-2ylzA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ynm | LIGHT-INDEPENDENTPROTOCHLOROPHYLLIDEREDUCTASEIRON-SULFURATP-BINDING PROTEIN (Prochlorococcusmarinus) |
PF00142(Fer4_NifH) | 5 | VAL A 152LEU A 153GLY A 159ALA A 162LEU A 165 | None | 1.05A | 4otyB-2ynmA:undetectable | 4otyB-2ynmA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a3h | ENDOGLUCANASE (Salipaludibacillusagaradhaerens) |
PF00150(Cellulase) | 5 | LEU A 264SER A 34TRP A 56GLY A 31ALA A 260 | None | 1.08A | 4otyB-3a3hA:undetectable | 4otyB-3a3hA:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f3z | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE WITH A KINASEDOMAIN AND 4CALMODULIN LIKE EFHANDS (Cryptosporidiumparvum) |
PF00069(Pkinase) | 5 | LEU A 263GLY A 211ALA A 210SER A 209LEU A 149 | None | 1.06A | 4otyB-3f3zA:undetectable | 4otyB-3f3zA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | LEU A 235VAL A 267GLY A 270SER A 274LEU A 275 | NoneNAD A 601 (-3.7A)NoneNoneNone | 0.91A | 4otyB-3glqA:undetectable | 4otyB-3glqA:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h2s | PUTATIVE NADH-FLAVINREDUCTASE (Lactobacillusparacasei) |
PF13460(NAD_binding_10) | 5 | VAL A 27LEU A 28VAL A 31GLY A 7ALA A 8 | NoneNoneNoneNDP A 301 (-3.2A)None | 1.05A | 4otyB-3h2sA:undetectable | 4otyB-3h2sA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i6u | SERINE/THREONINE-PROTEIN KINASE CHK2 (Homo sapiens) |
PF00069(Pkinase)PF00498(FHA) | 5 | LEU A 421SER A 422TYR A 424TRP A 485LEU A 467 | None | 1.09A | 4otyB-3i6uA:undetectable | 4otyB-3i6uA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ikf | 2-C-METHYL-D-ERYTHRITOL2,4-CYCLODIPHOSPHATESYNTHASE (Burkholderiapseudomallei) |
PF02542(YgbB) | 5 | VAL A 96SER A 98GLY A 6ALA A 49LEU A 50 | None | 1.06A | 4otyB-3ikfA:undetectable | 4otyB-3ikfA:14.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3is5 | CALCIUM-DEPENDENTPROTEIN KINASE (Toxoplasmagondii) |
PF00069(Pkinase) | 5 | LEU A 374GLY A 323ALA A 322SER A 321LEU A 261 | None | 1.01A | 4otyB-3is5A:undetectable | 4otyB-3is5A:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khn | MOTB PROTEIN,PUTATIVE (Desulfovibriovulgaris) |
PF00691(OmpA) | 5 | VAL A 49SER A 51GLY A 65ALA A 66LEU A 70 | None | 0.81A | 4otyB-3khnA:undetectable | 4otyB-3khnA:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l7z | PROBABLE EXOSOMECOMPLEX EXONUCLEASE2 (Sulfolobussolfataricus) |
PF01138(RNase_PH)PF03725(RNase_PH_C) | 5 | LEU A 189LEU A 142VAL A 162ALA A 163LEU A 44 | None | 1.07A | 4otyB-3l7zA:undetectable | 4otyB-3l7zA:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nbm | PTS SYSTEM,LACTOSE-SPECIFICIIBC COMPONENTS (Streptococcuspneumoniae) |
PF02302(PTS_IIB) | 5 | VAL A 512LEU A 508TYR A 538VAL A 460GLY A 491 | None | 1.09A | 4otyB-3nbmA:undetectable | 4otyB-3nbmA:14.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r5g | CYAB (Pseudomonasaeruginosa) |
PF00211(Guanylate_cyc) | 5 | LEU A 228TYR A 336GLY A 291ALA A 292LEU A 381 | None | 1.06A | 4otyB-3r5gA:undetectable | 4otyB-3r5gA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3re2 | PREDICTED PROTEIN (Nematostellavectensis) |
PF05053(Menin) | 5 | VAL A 378LEU A 379GLY A 410SER A 408LEU A 351 | None | 0.95A | 4otyB-3re2A:undetectable | 4otyB-3re2A:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tfy | N-ALPHA-ACETYLTRANSFERASE 50, NATECATALYTIC SUBUNIT (Homo sapiens) |
PF00583(Acetyltransf_1) | 5 | VAL A 11TYR A 36TYR A 50GLY A 57ALA A 58 | None | 0.99A | 4otyB-3tfyA:undetectable | 4otyB-3tfyA:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uw2 | PHOSPHOGLUCOMUTASE/PHOSPHOMANNOMUTASEFAMILY PROTEIN (Burkholderiathailandensis) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | TYR A 338TRP A 337VAL A 82ALA A 86LEU A 91 | None | 1.04A | 4otyB-3uw2A:undetectable | 4otyB-3uw2A:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxw | ADIPONECTIN RECEPTORPROTEIN 2 (Homo sapiens) |
PF03006(HlyIII) | 5 | LEU A 320TYR A 321VAL A 356GLY A 358ALA A 359 | None | 1.02A | 4otyB-3wxwA:undetectable | 4otyB-3wxwA:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxx | ACRH (Aeromonashydrophila) |
no annotation | 5 | LEU A 130SER A 127GLY A 146ALA A 145LEU A 141 | None | 0.89A | 4otyB-3wxxA:undetectable | 4otyB-3wxxA:13.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x0y | DSZC (Rhodococcuserythropolis) |
PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N)PF08028(Acyl-CoA_dh_2) | 5 | LEU A 93TYR A 96GLY A 164ALA A 165LEU A 171 | NoneFMN A 500 (-3.4A)NoneNoneNone | 0.91A | 4otyB-3x0yA:undetectable | 4otyB-3x0yA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c13 | UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE--L-LYSINE LIGASE (Staphylococcusaureus) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | TYR A 247GLY A 216ALA A 218SER A 220LEU A 221 | NoneKCX A 219 ( 4.5A)KCX A 219 ( 3.1A)KCX A 219 ( 4.3A)None | 1.09A | 4otyB-4c13A:undetectable | 4otyB-4c13A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4czp | EXTRALONG MANGANESEPEROXIDASE (Gelatoporiasubvermispora) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 5 | VAL A 28VAL A 112GLY A 110ALA A 109LEU A 90 | None | 1.08A | 4otyB-4czpA:0.0 | 4otyB-4czpA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4doe | 1,4-BETA-GLUCANASE (Caldicellulosiruptorbescii) |
PF00759(Glyco_hydro_9) | 5 | LEU A 346VAL A 284GLY A 287ALA A 288LEU A 292 | None | 1.03A | 4otyB-4doeA:undetectable | 4otyB-4doeA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dpp | DIHYDRODIPICOLINATESYNTHASE 2,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00701(DHDPS) | 5 | VAL A 337LEU A 336LEU A 325ALA A 307LEU A 311 | None | 1.05A | 4otyB-4dppA:undetectable | 4otyB-4dppA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dpy | MEVALONATEDIPHOSPHATEDECARBOXYLASE (Staphylococcusepidermidis) |
PF00288(GHMP_kinases_N) | 5 | LEU A 176SER A 177VAL A 36GLY A 149SER A 320 | None | 1.08A | 4otyB-4dpyA:undetectable | 4otyB-4dpyA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dwq | TRNA-SPLICING LIGASERTCB (Pyrococcushorikoshii) |
PF01139(RtcB) | 5 | VAL A 147LEU A 148GLY A 191ALA A 192LEU A 139 | None | 1.08A | 4otyB-4dwqA:undetectable | 4otyB-4dwqA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ej6 | PUTATIVEZINC-BINDINGDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | VAL A 31LEU A 134VAL A 137GLY A 139ALA A 140 | None | 1.05A | 4otyB-4ej6A:undetectable | 4otyB-4ej6A:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hka | TRYPTOPHAN2,3-DIOXYGENASE (Drosophilamelanogaster) |
PF03301(Trp_dioxygenase) | 5 | VAL A 189LEU A 199GLY A 275ALA A 276LEU A 295 | None | 1.06A | 4otyB-4hkaA:undetectable | 4otyB-4hkaA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9u | TRK SYSTEM POTASSIUMUPTAKE PROTEIN TRKH (Vibrioparahaemolyticus) |
PF02386(TrkH) | 6 | LEU A 109VAL A 79GLY A 81ALA A 83SER A 85LEU A 86 | None | 1.39A | 4otyB-4j9uA:3.0 | 4otyB-4j9uA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ky0 | PROTON/GLUTAMATESYMPORTER, SDFFAMILY (Thermococcuskodakarensis) |
PF00375(SDF) | 5 | VAL A 153LEU A 154GLY A 309ALA A 310LEU A 284 | None | 1.04A | 4otyB-4ky0A:undetectable | 4otyB-4ky0A:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | LEU A 233VAL A 265GLY A 268SER A 272LEU A 273 | NoneNAD A 503 (-3.6A)NoneNoneNone | 0.85A | 4otyB-4lvcA:undetectable | 4otyB-4lvcA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m3n | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Meiothermusruber) |
PF01048(PNP_UDP_1) | 6 | VAL A 153LEU A 154LEU A 206GLY A 92ALA A 91LEU A 200 | None | 1.41A | 4otyB-4m3nA:undetectable | 4otyB-4m3nA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m3n | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Meiothermusruber) |
PF01048(PNP_UDP_1) | 6 | VAL A 153LEU A 154SER A 155GLY A 92ALA A 91LEU A 200 | None | 1.27A | 4otyB-4m3nA:undetectable | 4otyB-4m3nA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1m | ENOYL-ACYL CARRIERREDUCTASE (Toxoplasmagondii) |
PF13561(adh_short_C2) | 5 | LEU A 286VAL A 266GLY A 268ALA A 270LEU A 274 | None | 0.91A | 4otyB-4o1mA:undetectable | 4otyB-4o1mA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ogc | HNH ENDONUCLEASEDOMAIN PROTEIN (Actinomycesnaeslundii) |
PF01844(HNH) | 5 | LEU A 43SER A 44GLY A 15ALA A 740SER A 741 | None | 0.96A | 4otyB-4ogcA:undetectable | 4otyB-4ogcA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oye | 425AA LONGHYPOTHETICAL PROTONGLUTAMATE SYMPORTPROTEIN (Pyrococcushorikoshii) |
PF00375(SDF) | 5 | VAL A 151LEU A 152GLY A 306ALA A 307LEU A 282 | None | 1.04A | 4otyB-4oyeA:undetectable | 4otyB-4oyeA:20.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 7 | SER A 354TYR A 356LEU A 526VAL A 524ALA A 528SER A 531LEU A 532 | NoneIBP A 601 (-4.5A)NoneIBP A 601 ( 4.0A)IBP A 601 (-3.4A)IBP A 601 ( 3.3A)IBP A 601 ( 4.9A) | 1.27A | 4otyB-4ph9A:63.6 | 4otyB-4ph9A:99.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 7 | SER A 354TYR A 356LEU A 526VAL A 524GLY A 527ALA A 528LEU A 532 | NoneIBP A 601 (-4.5A)NoneIBP A 601 ( 4.0A)IBP A 601 (-3.9A)IBP A 601 (-3.4A)IBP A 601 ( 4.9A) | 1.37A | 4otyB-4ph9A:63.6 | 4otyB-4ph9A:99.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 10 | VAL A 350LEU A 353SER A 354TYR A 356LEU A 385TRP A 388VAL A 524GLY A 527ALA A 528LEU A 532 | IBP A 601 (-4.3A)IBP A 601 ( 4.7A)NoneIBP A 601 (-4.5A)NoneNoneIBP A 601 ( 4.0A)IBP A 601 (-3.9A)IBP A 601 (-3.4A)IBP A 601 ( 4.9A) | 0.56A | 4otyB-4ph9A:63.6 | 4otyB-4ph9A:99.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 10 | VAL A 350LEU A 353SER A 354TYR A 356TYR A 386TRP A 388VAL A 524ALA A 528SER A 531LEU A 532 | IBP A 601 (-4.3A)IBP A 601 ( 4.7A)NoneIBP A 601 (-4.5A)IBP A 601 (-4.8A)NoneIBP A 601 ( 4.0A)IBP A 601 (-3.4A)IBP A 601 ( 3.3A)IBP A 601 ( 4.9A) | 0.58A | 4otyB-4ph9A:63.6 | 4otyB-4ph9A:99.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 10 | VAL A 350LEU A 353SER A 354TYR A 356TYR A 386TRP A 388VAL A 524GLY A 527ALA A 528LEU A 532 | IBP A 601 (-4.3A)IBP A 601 ( 4.7A)NoneIBP A 601 (-4.5A)IBP A 601 (-4.8A)NoneIBP A 601 ( 4.0A)IBP A 601 (-3.9A)IBP A 601 (-3.4A)IBP A 601 ( 4.9A) | 0.33A | 4otyB-4ph9A:63.6 | 4otyB-4ph9A:99.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pht | TYPE II SECRETIONSYSTEM PROTEIN L (Vibriovulnificus) |
PF05134(T2SSL) | 5 | LEU X 96VAL X 62GLY X 112SER X 99LEU X 101 | None | 1.03A | 4otyB-4phtX:undetectable | 4otyB-4phtX:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tym | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Streptococcusagalactiae) |
PF01048(PNP_UDP_1) | 6 | VAL A 175LEU A 176SER A 177LEU A 228GLY A 114ALA A 113 | None | 1.12A | 4otyB-4tymA:undetectable | 4otyB-4tymA:16.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ubt | ACETYL-COAACETYLTRANSFERASEFADA5 (Mycobacteriumtuberculosis) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | VAL A 234LEU A 228GLY A 243ALA A 242SER A 245 | NoneNoneCOA A 401 ( 4.3A)COA A 401 (-3.5A)COA A 401 ( 4.0A) | 0.96A | 4otyB-4ubtA:undetectable | 4otyB-4ubtA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xyd | NITRIC-OXIDEREDUCTASE SUBUNIT B (Roseobacterdenitrificans) |
PF00115(COX1) | 5 | VAL A 344LEU A 375VAL A 426GLY A 429ALA A 430 | NoneNoneHEM A 501 ( 4.5A)NoneNone | 1.02A | 4otyB-4xydA:undetectable | 4otyB-4xydA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zqb | NADP-DEPENDENTDEHYDROGENASE (Rhodobactersphaeroides) |
PF02826(2-Hacid_dh_C) | 5 | VAL A 176LEU A 198GLY A 149ALA A 150LEU A 154 | None | 1.08A | 4otyB-4zqbA:undetectable | 4otyB-4zqbA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b1q | U14 PROTEIN (Humanbetaherpesvirus6B) |
PF04637(Herpes_pp85) | 5 | LEU A 447VAL A 434GLY A 437ALA A 438SER A 441 | None | 0.80A | 4otyB-5b1qA:undetectable | 4otyB-5b1qA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bz4 | BETA-KETOTHIOLASE (Mycolicibacteriumsmegmatis) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | VAL A 240LEU A 234GLY A 253ALA A 252SER A 255 | None | 0.99A | 4otyB-5bz4A:undetectable | 4otyB-5bz4A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fii | PHENYLALANINE-4-HYDROXYLASE (Homo sapiens) |
PF01842(ACT) | 5 | VAL A 51LEU A 54GLY A 103ALA A 104LEU A 41 | None | 1.07A | 4otyB-5fiiA:undetectable | 4otyB-5fiiA:11.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gju | ATP-DEPENDENT RNAHELICASE DEAD (Escherichiacoli) |
PF00270(DEAD) | 5 | LEU A 155LEU A 136VAL A 79GLY A 131LEU A 86 | None | 1.08A | 4otyB-5gjuA:undetectable | 4otyB-5gjuA:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5grm | STIMULATOR OFINTERFERON GENESPROTEIN (Rattusnorvegicus) |
no annotation | 5 | LEU A 259LEU A 330GLY A 255ALA A 256LEU A 190 | None | 0.99A | 4otyB-5grmA:undetectable | 4otyB-5grmA:19.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ikr | PROSTAGLANDIN G/HSYNTHASE 2 (Homo sapiens) |
PF00008(EGF)PF03098(An_peroxidase) | 11 | VAL A 349LEU A 352SER A 353TYR A 355LEU A 384TRP A 387VAL A 523GLY A 526ALA A 527SER A 530LEU A 531 | ID8 A 601 (-3.9A)ID8 A 601 (-4.1A)ID8 A 601 ( 4.7A)ID8 A 601 (-3.8A)ID8 A 601 ( 4.8A)COH A 602 (-4.5A)ID8 A 601 (-3.6A)ID8 A 601 (-3.5A)ID8 A 601 (-3.5A)ID8 A 601 (-2.7A)ID8 A 601 (-3.5A) | 0.60A | 4otyB-5ikrA:34.1 | 4otyB-5ikrA:88.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ikr | PROSTAGLANDIN G/HSYNTHASE 2 (Homo sapiens) |
PF00008(EGF)PF03098(An_peroxidase) | 11 | VAL A 349LEU A 352SER A 353TYR A 355TYR A 385TRP A 387VAL A 523GLY A 526ALA A 527SER A 530LEU A 531 | ID8 A 601 (-3.9A)ID8 A 601 (-4.1A)ID8 A 601 ( 4.7A)ID8 A 601 (-3.8A)ID8 A 601 ( 3.5A)COH A 602 (-4.5A)ID8 A 601 (-3.6A)ID8 A 601 (-3.5A)ID8 A 601 (-3.5A)ID8 A 601 (-2.7A)ID8 A 601 (-3.5A) | 0.40A | 4otyB-5ikrA:34.1 | 4otyB-5ikrA:88.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5in8 | ARISTOLOCHENESYNTHASE (Aspergillusterreus) |
no annotation | 5 | VAL A 272LEU A 275SER A 276LEU A 190ALA A 286 | None | 0.97A | 4otyB-5in8A:undetectable | 4otyB-5in8A:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jfm | ALDEHYDEDEHYDROGENASE (Rhodopseudomonaspalustris) |
PF00171(Aldedh) | 5 | VAL A 205LEU A 244VAL A 120GLY A 122LEU A 128 | None | 1.04A | 4otyB-5jfmA:undetectable | 4otyB-5jfmA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jvb | PHOSPHONATE ABCTRANSPORTER,PERIPLASMICPHOSPHONATE-BINDINGPROTEIN (Trichodesmiumerythraeum) |
no annotation | 6 | VAL A 163LEU A 177TYR A 125VAL A 104GLY A 106ALA A 174 | None | 1.28A | 4otyB-5jvbA:undetectable | 4otyB-5jvbA:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m32 | PROTEASOME SUBUNITBETA TYPE-2 (Homo sapiens) |
PF00227(Proteasome) | 5 | LEU J 4TYR J 117GLY J 135ALA J 136LEU J 140 | None | 0.96A | 4otyB-5m32J:undetectable | 4otyB-5m32J:15.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mul | NEURAMINIDASE (Bacteroidesthetaiotaomicron) |
PF15892(BNR_4) | 5 | VAL A 46LEU A 45SER A 44GLY A 66LEU A 103 | None | 1.02A | 4otyB-5mulA:undetectable | 4otyB-5mulA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n4a | INTRAFLAGELLARTRANSPORT PROTEIN 80 (Chlamydomonasreinhardtii) |
no annotation | 5 | LEU A 371LEU A 388GLY A 393ALA A 392SER A 391 | NoneNoneGOL A 807 ( 4.7A)NoneNone | 1.04A | 4otyB-5n4aA:undetectable | 4otyB-5n4aA:9.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n7q | PUTATIVE CATHEPSIN D (Ixodes ricinus) |
no annotation | 5 | VAL A 270LEU A 281LEU A 232GLY A 301LEU A 247 | None | 0.99A | 4otyB-5n7qA:undetectable | 4otyB-5n7qA:8.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tnx | ALCOHOLDEHYDROGENASEZINC-BINDING DOMAINPROTEIN (Burkholderiaambifaria) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | TYR A 110GLY A 320ALA A 184SER A 188LEU A 189 | None | 0.88A | 4otyB-5tnxA:undetectable | 4otyB-5tnxA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uld | TRANSPORTER, NADCFAMILY (Vibrio cholerae) |
PF00939(Na_sulph_symp) | 5 | LEU A 270VAL A 295GLY A 298ALA A 299LEU A 303 | None | 0.96A | 4otyB-5uldA:undetectable | 4otyB-5uldA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5veb | CADHERIN-6 (Homo sapiens) |
PF00028(Cadherin) | 6 | VAL X 568LEU X 527SER X 526LEU X 550GLY X 548ALA X 547 | None | 1.06A | 4otyB-5vebX:undetectable | 4otyB-5vebX:10.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | VAL A 273LEU A 192GLY A 227ALA A 229LEU A 232 | None | 1.09A | 4otyB-5w4bA:undetectable | 4otyB-5w4bA:19.33 |