SIMILAR PATTERNS OF AMINO ACIDS FOR 4OTY_A_LURA705_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)


(Thermotoga
maritima)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 VAL A  95
LEU A 370
VAL A 345
GLY A 343
ALA A 342
None
1.06A 4otyA-1b3bA:
1.0
4otyA-1b3bA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)


(Thermococcus
litoralis)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 VAL A  95
LEU A 372
VAL A 347
GLY A 345
ALA A 344
None
1.01A 4otyA-1bvuA:
0.9
4otyA-1bvuA:
20.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE


(Ovis aries)
PF00008
(EGF)
PF03098
(An_peroxidase)
8 VAL A 349
LEU A 352
SER A 353
TYR A 355
LEU A 384
GLY A 526
ALA A 527
LEU A 531
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
0.65A 4otyA-1ebvA:
30.7
4otyA-1ebvA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE


(Ovis aries)
PF00008
(EGF)
PF03098
(An_peroxidase)
9 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
0.39A 4otyA-1ebvA:
30.7
4otyA-1ebvA:
64.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtm GLUTAMATE
DEHYDROGENASE


(Pyrococcus
furiosus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 VAL A  95
LEU A 373
VAL A 348
GLY A 346
ALA A 345
None
1.08A 4otyA-1gtmA:
1.0
4otyA-1gtmA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5


(Homo sapiens)
PF00069
(Pkinase)
5 LEU A 267
GLY A 189
ALA A 188
SER A 187
LEU A 127
None
1.03A 4otyA-1h4lA:
undetectable
4otyA-1h4lA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia5 POLYGALACTURONASE

(Aspergillus
aculeatus)
PF00295
(Glyco_hydro_28)
6 VAL A  26
LEU A  27
SER A  28
LEU A 120
GLY A  78
ALA A  79
None
1.44A 4otyA-1ia5A:
0.0
4otyA-1ia5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE


(Homo sapiens)
PF06087
(Tyr-DNA_phospho)
5 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
None
1.01A 4otyA-1jy1A:
0.0
4otyA-1jy1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH


(Homo sapiens)
PF01808
(AICARFT_IMPCHas)
PF02142
(MGS)
5 VAL A  99
LEU A   8
LEU A  68
GLY A 127
LEU A 132
None
None
XMP  A 901 (-4.1A)
XMP  A 901 (-3.4A)
None
1.01A 4otyA-1pl0A:
undetectable
4otyA-1pl0A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori)
PF01264
(Chorismate_synt)
5 LEU A 341
VAL A 133
GLY A 136
ALA A 137
LEU A  38
None
1.04A 4otyA-1umfA:
0.0
4otyA-1umfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb4 COAT PROTEIN

(Sesbania mosaic
virus)
PF00729
(Viral_coat)
5 VAL A 155
LEU A 158
SER A 159
GLY A 167
SER A 138
None
1.03A 4otyA-1vb4A:
undetectable
4otyA-1vb4A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE


(Thermotoga
maritima)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 LEU A  74
GLY A   8
ALA A   9
SER A  34
LEU A  55
None
1.10A 4otyA-1vknA:
undetectable
4otyA-1vknA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a35 HYPOTHETICAL PROTEIN
PA4017


(Pseudomonas
aeruginosa)
PF08732
(HIM1)
5 LEU A   9
LEU A  73
GLY A  12
ALA A  13
LEU A  22
None
1.09A 4otyA-2a35A:
undetectable
4otyA-2a35A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4v PEROXIREDOXIN DOT5

(Saccharomyces
cerevisiae)
PF00578
(AhpC-TSA)
5 VAL A  98
LEU A 130
SER A 131
LEU A 162
GLY A 161
None
1.07A 4otyA-2a4vA:
undetectable
4otyA-2a4vA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ark FLAVODOXIN

(Aquifex
aeolicus)
PF00258
(Flavodoxin_1)
5 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
None
1.00A 4otyA-2arkA:
undetectable
4otyA-2arkA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE


(Homo sapiens)
PF01869
(BcrAD_BadFG)
5 LEU A  75
SER A  76
LEU A 318
GLY A 110
SER A 311
None
1.00A 4otyA-2ch6A:
undetectable
4otyA-2ch6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL


(Homo sapiens)
PF00682
(HMGL-like)
5 LEU A 299
VAL A 260
GLY A 262
ALA A 261
SER A 316
None
1.06A 4otyA-2cw6A:
undetectable
4otyA-2cw6A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE


(Pyrococcus
horikoshii)
PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB)
5 VAL A 182
LEU A 181
LEU A 164
GLY A  82
ALA A  83
None
1.09A 4otyA-2djzA:
2.0
4otyA-2djzA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejb PROBABLE AROMATIC
ACID DECARBOXYLASE


(Aquifex
aeolicus)
PF02441
(Flavoprotein)
5 SER A  75
LEU A 121
VAL A 113
GLY A 111
LEU A 106
None
1.08A 4otyA-2ejbA:
undetectable
4otyA-2ejbA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE


(Thermus
thermophilus)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
5 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 285
None
1.05A 4otyA-2elcA:
undetectable
4otyA-2elcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exa PENICILLIN-BINDING
PROTEIN 4


(Escherichia
coli)
PF02113
(Peptidase_S13)
5 LEU A 303
LEU A 374
GLY A 429
ALA A 416
SER A 415
None
None
None
None
GOL  A 502 (-2.3A)
1.08A 4otyA-2exaA:
undetectable
4otyA-2exaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE


(Pseudomonas
aeruginosa)
PF00682
(HMGL-like)
5 VAL A 274
LEU A 273
GLY A 236
ALA A 235
SER A 290
None
1.07A 4otyA-2ftpA:
undetectable
4otyA-2ftpA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ib0 CONSERVED
HYPOTHETICAL ALANINE
RICH PROTEIN


(Mycobacterium
tuberculosis)
PF14530
(DUF4439)
5 VAL A 147
LEU A 148
LEU A 102
VAL A 104
LEU A  54
None
0.95A 4otyA-2ib0A:
undetectable
4otyA-2ib0A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6i FORMATE
DEHYDROGENASE


([Candida]
boidinii)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 LEU A 238
TYR A 194
VAL A 227
GLY A 171
ALA A 229
None
1.07A 4otyA-2j6iA:
undetectable
4otyA-2j6iA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2of3 ZYG-9

(Caenorhabditis
elegans)
no annotation 5 LEU A 777
LEU A 790
VAL A 824
ALA A 828
LEU A 832
None
0.94A 4otyA-2of3A:
undetectable
4otyA-2of3A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE


(Ruegeria sp.
TM1040)
PF07859
(Abhydrolase_3)
5 TRP A  81
GLY A 138
ALA A 137
SER A 136
LEU A 168
None
None
None
UNL  A 263 (-3.7A)
None
1.05A 4otyA-2pblA:
undetectable
4otyA-2pblA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1


(Homo sapiens)
PF00151
(Lipase)
PF01477
(PLAT)
5 LEU A 209
VAL A 176
GLY A 178
ALA A 180
SER A 182
None
None
CA  A 478 ( 4.9A)
None
None
0.96A 4otyA-2pplA:
undetectable
4otyA-2pplA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7d RIBONUCLEASE II
FAMILY PROTEIN


(Deinococcus
radiodurans)
PF00773
(RNB)
5 VAL A 120
LEU A 173
SER A 174
GLY A 274
ALA A 273
None
0.95A 4otyA-2r7dA:
undetectable
4otyA-2r7dA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ru4 ARMADILLO REPEAT
PROTEIN, C-TERMINAL
FRAGMENT, MAII
ARMADILLO REPEAT
PROTEIN, N-TERMINAL
FRAGMENT, YIIM2


(synthetic
construct)
PF00514
(Arm)
PF16186
(Arm_3)
5 SER A 110
VAL B 123
GLY B 127
ALA B 128
LEU B 132
None
1.01A 4otyA-2ru4A:
undetectable
4otyA-2ru4A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC


(Mycobacterium
tuberculosis)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 LEU A 103
VAL A 475
GLY A 478
ALA A 479
LEU A 483
None
0.91A 4otyA-2vosA:
undetectable
4otyA-2vosA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq0 COAT PROTEIN

(Sesbania mosaic
virus)
PF00729
(Viral_coat)
5 VAL A 155
LEU A 158
SER A 159
GLY A 167
SER A 138
None
1.03A 4otyA-2vq0A:
undetectable
4otyA-2vq0A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME


(Escherichia
coli)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
5 SER A 421
TRP A 579
GLY A 412
ALA A 413
LEU A 409
None
0.89A 4otyA-2wskA:
undetectable
4otyA-2wskA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wua ACETOACETYL COA
THIOLASE


(Helianthus
annuus)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 VAL A 277
LEU A 271
GLY A 287
ALA A 286
SER A 289
None
1.10A 4otyA-2wuaA:
undetectable
4otyA-2wuaA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy0 ANGIOTENSINOGEN

(Mus musculus)
PF00079
(Serpin)
5 VAL C 130
LEU C 128
LEU C 114
GLY C 143
LEU C  11
None
None
NA  C1456 ( 4.9A)
NA  C1456 (-4.0A)
None
0.97A 4otyA-2wy0C:
undetectable
4otyA-2wy0C:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE


(Nocardia
farcinica)
no annotation 5 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
None
1.00A 4otyA-2xecA:
undetectable
4otyA-2xecA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn8 PUTATIVE CYTOCHROME
P450 125


(Mycobacterium
tuberculosis)
PF00067
(p450)
5 VAL A 313
LEU A 415
VAL A 267
GLY A 269
ALA A 268
HEM  A1434 ( 4.9A)
None
None
HEM  A1434 (-3.3A)
HEM  A1434 (-3.5A)
1.02A 4otyA-2xn8A:
0.7
4otyA-2xn8A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylz PHENYLACETONE
MONOOXYGENASE


(Thermobifida
fusca)
PF13738
(Pyr_redox_3)
5 LEU A 146
VAL A  21
GLY A  23
ALA A 149
SER A 150
None
None
FAD  A 700 (-3.3A)
None
FAD  A 700 (-4.9A)
1.06A 4otyA-2ylzA:
undetectable
4otyA-2ylzA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN


(Prochlorococcus
marinus)
PF00142
(Fer4_NifH)
5 VAL A 152
LEU A 153
GLY A 159
ALA A 162
LEU A 165
None
1.03A 4otyA-2ynmA:
undetectable
4otyA-2ynmA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]


(Thermus
thermophilus)
PF00117
(GATase)
PF00958
(GMP_synt_C)
6 LEU A 225
SER A 222
LEU A 196
VAL A 362
ALA A 366
LEU A 371
None
1.48A 4otyA-2ywbA:
undetectable
4otyA-2ywbA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3h ENDOGLUCANASE

(Salipaludibacillus
agaradhaerens)
PF00150
(Cellulase)
5 LEU A 264
SER A  34
TRP A  56
GLY A  31
ALA A 260
None
1.10A 4otyA-3a3hA:
undetectable
4otyA-3a3hA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfa CALCIUM-DEPENDENT
PROTEIN KINASE
CGD3_920


(Cryptosporidium
parvum)
PF00069
(Pkinase)
5 LEU A 244
GLY A 192
ALA A 191
SER A 190
LEU A 130
None
1.11A 4otyA-3dfaA:
undetectable
4otyA-3dfaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS


(Cryptosporidium
parvum)
PF00069
(Pkinase)
5 LEU A 263
GLY A 211
ALA A 210
SER A 209
LEU A 149
None
1.08A 4otyA-3f3zA:
undetectable
4otyA-3f3zA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2s PUTATIVE NADH-FLAVIN
REDUCTASE


(Lactobacillus
paracasei)
PF13460
(NAD_binding_10)
5 VAL A  27
LEU A  28
VAL A  31
GLY A   7
ALA A   8
None
None
None
NDP  A 301 (-3.2A)
None
1.03A 4otyA-3h2sA:
undetectable
4otyA-3h2sA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikf 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE


(Burkholderia
pseudomallei)
PF02542
(YgbB)
5 VAL A  96
SER A  98
GLY A   6
ALA A  49
LEU A  50
None
1.09A 4otyA-3ikfA:
undetectable
4otyA-3ikfA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE


(Toxoplasma
gondii)
PF00069
(Pkinase)
5 LEU A 374
GLY A 323
ALA A 322
SER A 321
LEU A 261
None
1.02A 4otyA-3is5A:
undetectable
4otyA-3is5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khn MOTB PROTEIN,
PUTATIVE


(Desulfovibrio
vulgaris)
PF00691
(OmpA)
5 VAL A  49
SER A  51
GLY A  65
ALA A  66
LEU A  70
None
0.80A 4otyA-3khnA:
undetectable
4otyA-3khnA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2


(Sulfolobus
solfataricus)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
5 LEU A 189
LEU A 142
VAL A 162
ALA A 163
LEU A  44
None
1.05A 4otyA-3l7zA:
undetectable
4otyA-3l7zA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyq MALONYL-COA LIGASE

(Streptomyces
coelicolor)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 VAL A  53
LEU A 100
LEU A  70
VAL A  63
LEU A 191
None
1.02A 4otyA-3nyqA:
undetectable
4otyA-3nyqA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)


(Leishmania
major)
PF00069
(Pkinase)
5 LEU A 300
GLY A 220
ALA A 219
SER A 218
LEU A 159
None
1.10A 4otyA-3pg1A:
undetectable
4otyA-3pg1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5g CYAB

(Pseudomonas
aeruginosa)
PF00211
(Guanylate_cyc)
5 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
None
1.05A 4otyA-3r5gA:
undetectable
4otyA-3r5gA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re2 PREDICTED PROTEIN

(Nematostella
vectensis)
PF05053
(Menin)
5 VAL A 378
LEU A 379
GLY A 410
SER A 408
LEU A 351
None
0.96A 4otyA-3re2A:
undetectable
4otyA-3re2A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN


(Burkholderia
thailandensis)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
5 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.02A 4otyA-3uw2A:
undetectable
4otyA-3uw2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxw ADIPONECTIN RECEPTOR
PROTEIN 2


(Homo sapiens)
PF03006
(HlyIII)
5 LEU A 320
TYR A 321
VAL A 356
GLY A 358
ALA A 359
None
1.06A 4otyA-3wxwA:
undetectable
4otyA-3wxwA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxx ACRH

(Aeromonas
hydrophila)
no annotation 5 LEU A 130
SER A 127
GLY A 146
ALA A 145
LEU A 141
None
0.86A 4otyA-3wxxA:
undetectable
4otyA-3wxxA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2)
5 LEU A  93
TYR A  96
GLY A 164
ALA A 165
LEU A 171
None
FMN  A 500 (-3.4A)
None
None
None
0.90A 4otyA-3x0yA:
undetectable
4otyA-3x0yA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE


(Gelatoporia
subvermispora)
PF00141
(peroxidase)
PF11895
(Peroxidase_ext)
5 VAL A  28
VAL A 112
GLY A 110
ALA A 109
LEU A  90
None
1.10A 4otyA-4czpA:
undetectable
4otyA-4czpA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii)
PF00759
(Glyco_hydro_9)
5 LEU A 346
VAL A 284
GLY A 287
ALA A 288
LEU A 292
None
1.03A 4otyA-4doeA:
undetectable
4otyA-4doeA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00701
(DHDPS)
5 VAL A 337
LEU A 336
LEU A 325
ALA A 307
LEU A 311
None
1.07A 4otyA-4dppA:
undetectable
4otyA-4dppA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 VAL A  31
LEU A 134
VAL A 137
GLY A 139
ALA A 140
None
1.05A 4otyA-4ej6A:
undetectable
4otyA-4ej6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkl ALPHA-AMYLASE

(Thermotoga
neapolitana)
PF00128
(Alpha-amylase)
5 VAL A 100
LEU A 173
TYR A 141
GLY A 172
ALA A 171
None
1.10A 4otyA-4gklA:
undetectable
4otyA-4gklA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH


(Vibrio
parahaemolyticus)
PF02386
(TrkH)
6 LEU A 109
VAL A  79
GLY A  81
ALA A  83
SER A  85
LEU A  86
None
1.40A 4otyA-4j9uA:
undetectable
4otyA-4j9uA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)


(Bradyrhizobium
elkanii)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 LEU A 233
VAL A 265
GLY A 268
SER A 272
LEU A 273
None
NAD  A 503 (-3.6A)
None
None
None
0.82A 4otyA-4lvcA:
undetectable
4otyA-4lvcA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m3n PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE


(Meiothermus
ruber)
PF01048
(PNP_UDP_1)
6 VAL A 153
LEU A 154
LEU A 206
GLY A  92
ALA A  91
LEU A 200
None
1.42A 4otyA-4m3nA:
undetectable
4otyA-4m3nA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1m ENOYL-ACYL CARRIER
REDUCTASE


(Toxoplasma
gondii)
PF13561
(adh_short_C2)
5 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
None
0.94A 4otyA-4o1mA:
undetectable
4otyA-4o1mA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN


(Actinomyces
naeslundii)
PF01844
(HNH)
5 LEU A  43
SER A  44
GLY A  15
ALA A 740
SER A 741
None
0.94A 4otyA-4ogcA:
undetectable
4otyA-4ogcA:
18.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2


(Mus musculus)
PF00008
(EGF)
PF03098
(An_peroxidase)
6 LEU A 353
SER A 354
TYR A 356
LEU A 508
TRP A 388
VAL A 524
IBP  A 601 ( 4.7A)
None
IBP  A 601 (-4.5A)
None
None
IBP  A 601 ( 4.0A)
1.49A 4otyA-4ph9A:
63.6
4otyA-4ph9A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2


(Mus musculus)
PF00008
(EGF)
PF03098
(An_peroxidase)
6 SER A 354
TYR A 356
LEU A 526
ALA A 528
SER A 531
LEU A 532
None
IBP  A 601 (-4.5A)
None
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
IBP  A 601 ( 4.9A)
1.11A 4otyA-4ph9A:
63.6
4otyA-4ph9A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2


(Mus musculus)
PF00008
(EGF)
PF03098
(An_peroxidase)
6 SER A 354
TYR A 356
LEU A 526
GLY A 527
ALA A 528
LEU A 532
None
IBP  A 601 (-4.5A)
None
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 4.9A)
1.36A 4otyA-4ph9A:
63.6
4otyA-4ph9A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2


(Mus musculus)
PF00008
(EGF)
PF03098
(An_peroxidase)
10 VAL A 350
LEU A 353
SER A 354
TYR A 356
LEU A 385
TRP A 388
VAL A 524
GLY A 527
ALA A 528
LEU A 532
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
None
IBP  A 601 (-4.5A)
None
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 4.9A)
0.59A 4otyA-4ph9A:
63.6
4otyA-4ph9A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2


(Mus musculus)
PF00008
(EGF)
PF03098
(An_peroxidase)
10 VAL A 350
LEU A 353
SER A 354
TYR A 356
TYR A 386
TRP A 388
VAL A 524
ALA A 528
SER A 531
LEU A 532
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
None
IBP  A 601 (-4.5A)
IBP  A 601 (-4.8A)
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
IBP  A 601 ( 4.9A)
0.63A 4otyA-4ph9A:
63.6
4otyA-4ph9A:
99.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2


(Mus musculus)
PF00008
(EGF)
PF03098
(An_peroxidase)
10 VAL A 350
LEU A 353
SER A 354
TYR A 356
TYR A 386
TRP A 388
VAL A 524
GLY A 527
ALA A 528
LEU A 532
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
None
IBP  A 601 (-4.5A)
IBP  A 601 (-4.8A)
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 4.9A)
0.37A 4otyA-4ph9A:
63.6
4otyA-4ph9A:
99.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht TYPE II SECRETION
SYSTEM PROTEIN L


(Vibrio
vulnificus)
PF05134
(T2SSL)
5 LEU X  96
VAL X  62
GLY X 112
SER X  99
LEU X 101
None
1.05A 4otyA-4phtX:
undetectable
4otyA-4phtX:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnw NADPH DEHYDROGENASE
1


(Saccharomyces
pastorianus)
PF00724
(Oxidored_FMN)
5 VAL A 384
LEU A 341
VAL A 367
GLY A 369
ALA A 368
None
1.10A 4otyA-4rnwA:
undetectable
4otyA-4rnwA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnx NADPH DEHYDROGENASE
1


(Saccharomyces
pastorianus)
PF00724
(Oxidored_FMN)
5 VAL A 134
LEU A  91
VAL A 117
GLY A 119
ALA A 118
None
1.08A 4otyA-4rnxA:
undetectable
4otyA-4rnxA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tym PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE


(Streptococcus
agalactiae)
PF01048
(PNP_UDP_1)
5 VAL A 175
LEU A 176
SER A 177
GLY A 114
ALA A 113
None
1.06A 4otyA-4tymA:
undetectable
4otyA-4tymA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u GLOBIN A CHAIN

(Glossoscolex
paulistus)
PF00042
(Globin)
5 VAL A 124
LEU A  68
VAL A  36
GLY A  34
ALA A  35
None
1.10A 4otyA-4u8uA:
undetectable
4otyA-4u8uA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubt ACETYL-COA
ACETYLTRANSFERASE
FADA5


(Mycobacterium
tuberculosis)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 VAL A 234
LEU A 228
GLY A 243
ALA A 242
SER A 245
None
None
COA  A 401 ( 4.3A)
COA  A 401 (-3.5A)
COA  A 401 ( 4.0A)
0.93A 4otyA-4ubtA:
undetectable
4otyA-4ubtA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B


(Roseobacter
denitrificans)
PF00115
(COX1)
5 VAL A 344
LEU A 375
VAL A 426
GLY A 429
ALA A 430
None
None
HEM  A 501 ( 4.5A)
None
None
1.02A 4otyA-4xydA:
undetectable
4otyA-4xydA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN


(Sesbania mosaic
virus;
Staphylococcus
aureus)
no annotation 5 VAL A 155
LEU A 158
SER A 159
GLY A 167
SER A 138
None
1.09A 4otyA-4y5zA:
undetectable
4otyA-4y5zA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ync NADPH DEHYDROGENASE
1


(Saccharomyces
pastorianus)
PF00724
(Oxidored_FMN)
5 VAL A 285
LEU A 242
VAL A 268
GLY A 270
ALA A 269
None
1.09A 4otyA-4yncA:
undetectable
4otyA-4yncA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqb NADP-DEPENDENT
DEHYDROGENASE


(Rhodobacter
sphaeroides)
PF02826
(2-Hacid_dh_C)
5 VAL A 176
LEU A 198
GLY A 149
ALA A 150
LEU A 154
None
1.08A 4otyA-4zqbA:
undetectable
4otyA-4zqbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1q U14 PROTEIN

(Human
betaherpesvirus
6B)
PF04637
(Herpes_pp85)
5 LEU A 447
VAL A 434
GLY A 437
ALA A 438
SER A 441
None
0.83A 4otyA-5b1qA:
0.8
4otyA-5b1qA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz4 BETA-KETOTHIOLASE

(Mycolicibacterium
smegmatis)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 VAL A 240
LEU A 234
GLY A 253
ALA A 252
SER A 255
None
0.96A 4otyA-5bz4A:
undetectable
4otyA-5bz4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbk SHHTL5

(Striga
hermonthica)
PF12697
(Abhydrolase_6)
5 LEU A  77
VAL A 103
GLY A 101
ALA A 102
SER A  98
None
1.10A 4otyA-5cbkA:
undetectable
4otyA-5cbkA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fii PHENYLALANINE-4-HYDR
OXYLASE


(Homo sapiens)
PF01842
(ACT)
5 VAL A  51
LEU A  54
GLY A 103
ALA A 104
LEU A  41
None
1.09A 4otyA-5fiiA:
undetectable
4otyA-5fiiA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggy IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN


(Vibrio cholerae)
PF01497
(Peripla_BP_2)
5 VAL A  67
LEU A 113
VAL A  96
GLY A  76
ALA A  77
None
1.02A 4otyA-5ggyA:
undetectable
4otyA-5ggyA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gju ATP-DEPENDENT RNA
HELICASE DEAD


(Escherichia
coli)
PF00270
(DEAD)
5 LEU A 155
LEU A 136
VAL A  79
GLY A 131
LEU A  86
None
1.08A 4otyA-5gjuA:
undetectable
4otyA-5gjuA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grm STIMULATOR OF
INTERFERON GENES
PROTEIN


(Rattus
norvegicus)
no annotation 5 LEU A 259
LEU A 330
GLY A 255
ALA A 256
LEU A 190
None
1.03A 4otyA-5grmA:
undetectable
4otyA-5grmA:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2


(Homo sapiens)
PF00008
(EGF)
PF03098
(An_peroxidase)
10 VAL A 349
LEU A 352
SER A 353
TYR A 355
LEU A 384
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 4.8A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
0.63A 4otyA-5ikrA:
34.1
4otyA-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2


(Homo sapiens)
PF00008
(EGF)
PF03098
(An_peroxidase)
11 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
0.42A 4otyA-5ikrA:
34.1
4otyA-5ikrA:
88.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in8 ARISTOLOCHENE
SYNTHASE


(Aspergillus
terreus)
no annotation 5 VAL A 272
LEU A 275
SER A 276
LEU A 190
ALA A 286
None
1.00A 4otyA-5in8A:
undetectable
4otyA-5in8A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD


(Pseudomonas
aeruginosa)
PF04453
(OstA_C)
5 SER A 408
LEU A 384
VAL A 406
GLY A 424
ALA A 423
None
1.09A 4otyA-5ivaA:
undetectable
4otyA-5ivaA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE


(Rhodopseudomonas
palustris)
PF00171
(Aldedh)
5 VAL A 205
LEU A 244
VAL A 120
GLY A 122
LEU A 128
None
0.99A 4otyA-5jfmA:
undetectable
4otyA-5jfmA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN


(Trichodesmium
erythraeum)
no annotation 6 VAL A 163
LEU A 177
TYR A 125
VAL A 104
GLY A 106
ALA A 174
None
1.29A 4otyA-5jvbA:
undetectable
4otyA-5jvbA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4


(Bos taurus)
PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N)
5 LEU M  14
VAL M  25
ALA M  29
SER M  31
LEU M  32
None
1.08A 4otyA-5lc5M:
undetectable
4otyA-5lc5M:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 PROTEASOME SUBUNIT
BETA TYPE-2


(Homo sapiens)
PF00227
(Proteasome)
5 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
None
0.93A 4otyA-5m32J:
undetectable
4otyA-5m32J:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80


(Chlamydomonas
reinhardtii)
no annotation 5 LEU A 371
LEU A 388
GLY A 393
ALA A 392
SER A 391
None
None
GOL  A 807 ( 4.7A)
None
None
1.02A 4otyA-5n4aA:
undetectable
4otyA-5n4aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus)
no annotation 5 VAL A 270
LEU A 281
LEU A 232
GLY A 301
LEU A 247
None
1.06A 4otyA-5n7qA:
undetectable
4otyA-5n7qA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veb CADHERIN-6

(Homo sapiens)
PF00028
(Cadherin)
6 VAL X 568
LEU X 527
SER X 526
LEU X 550
GLY X 548
ALA X 547
None
1.06A 4otyA-5vebX:
undetectable
4otyA-5vebX:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1


(Streptococcus
pyogenes)
PF13395
(HNH_4)
PF16592
(Cas9_REC)
PF16593
(Cas9-BH)
PF16595
(Cas9_PI)
5 LEU A   9
GLY A  17
ALA A  50
SER A  15
LEU A  52
None
1.09A 4otyA-5xblA:
undetectable
4otyA-5xblA:
17.53