SIMILAR PATTERNS OF AMINO ACIDS FOR 4OTY_A_LURA705
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b3b | PROTEIN (GLUTAMATEDEHYDROGENASE) (Thermotogamaritima) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | VAL A 95LEU A 370VAL A 345GLY A 343ALA A 342 | None | 1.06A | 4otyA-1b3bA:1.0 | 4otyA-1b3bA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bvu | PROTEIN (GLUTAMATEDEHYDROGENASE) (Thermococcuslitoralis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | VAL A 95LEU A 372VAL A 347GLY A 345ALA A 344 | None | 1.01A | 4otyA-1bvuA:0.9 | 4otyA-1bvuA:20.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ebv | PROSTAGLANDIN H2SYNTHASE (Ovis aries) |
PF00008(EGF)PF03098(An_peroxidase) | 8 | VAL A 349LEU A 352SER A 353TYR A 355LEU A 384GLY A 526ALA A 527LEU A 531 | SCL A 700 ( 4.6A)SCL A 700 ( 4.8A)NoneSCL A 700 (-4.3A)NoneSCL A 700 ( 4.0A)SCL A 700 (-2.9A)OAS A 530 (-4.1A) | 0.65A | 4otyA-1ebvA:30.7 | 4otyA-1ebvA:64.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ebv | PROSTAGLANDIN H2SYNTHASE (Ovis aries) |
PF00008(EGF)PF03098(An_peroxidase) | 9 | VAL A 349LEU A 352SER A 353TYR A 355TYR A 385TRP A 387GLY A 526ALA A 527LEU A 531 | SCL A 700 ( 4.6A)SCL A 700 ( 4.8A)NoneSCL A 700 (-4.3A)NoneNoneSCL A 700 ( 4.0A)SCL A 700 (-2.9A)OAS A 530 (-4.1A) | 0.39A | 4otyA-1ebvA:30.7 | 4otyA-1ebvA:64.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gtm | GLUTAMATEDEHYDROGENASE (Pyrococcusfuriosus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | VAL A 95LEU A 373VAL A 348GLY A 346ALA A 345 | None | 1.08A | 4otyA-1gtmA:1.0 | 4otyA-1gtmA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h4l | CELL DIVISIONPROTEIN KINASE 5 (Homo sapiens) |
PF00069(Pkinase) | 5 | LEU A 267GLY A 189ALA A 188SER A 187LEU A 127 | None | 1.03A | 4otyA-1h4lA:undetectable | 4otyA-1h4lA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ia5 | POLYGALACTURONASE (Aspergillusaculeatus) |
PF00295(Glyco_hydro_28) | 6 | VAL A 26LEU A 27SER A 28LEU A 120GLY A 78ALA A 79 | None | 1.44A | 4otyA-1ia5A:0.0 | 4otyA-1ia5A:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jy1 | TYROSYL-DNAPHOSPHODIESTERASE (Homo sapiens) |
PF06087(Tyr-DNA_phospho) | 5 | VAL A 227TYR A 537ALA A 332SER A 334LEU A 335 | None | 1.01A | 4otyA-1jy1A:0.0 | 4otyA-1jy1A:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pl0 | BIFUNCTIONAL PURINEBIOSYNTHESIS PROTEINPURH (Homo sapiens) |
PF01808(AICARFT_IMPCHas)PF02142(MGS) | 5 | VAL A 99LEU A 8LEU A 68GLY A 127LEU A 132 | NoneNoneXMP A 901 (-4.1A)XMP A 901 (-3.4A)None | 1.01A | 4otyA-1pl0A:undetectable | 4otyA-1pl0A:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1umf | CHORISMATE SYNTHASE (Helicobacterpylori) |
PF01264(Chorismate_synt) | 5 | LEU A 341VAL A 133GLY A 136ALA A 137LEU A 38 | None | 1.04A | 4otyA-1umfA:0.0 | 4otyA-1umfA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vb4 | COAT PROTEIN (Sesbania mosaicvirus) |
PF00729(Viral_coat) | 5 | VAL A 155LEU A 158SER A 159GLY A 167SER A 138 | None | 1.03A | 4otyA-1vb4A:undetectable | 4otyA-1vb4A:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vkn | N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATEREDUCTASE (Thermotogamaritima) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | LEU A 74GLY A 8ALA A 9SER A 34LEU A 55 | None | 1.10A | 4otyA-1vknA:undetectable | 4otyA-1vknA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a35 | HYPOTHETICAL PROTEINPA4017 (Pseudomonasaeruginosa) |
PF08732(HIM1) | 5 | LEU A 9LEU A 73GLY A 12ALA A 13LEU A 22 | None | 1.09A | 4otyA-2a35A:undetectable | 4otyA-2a35A:16.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a4v | PEROXIREDOXIN DOT5 (Saccharomycescerevisiae) |
PF00578(AhpC-TSA) | 5 | VAL A 98LEU A 130SER A 131LEU A 162GLY A 161 | None | 1.07A | 4otyA-2a4vA:undetectable | 4otyA-2a4vA:13.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ark | FLAVODOXIN (Aquifexaeolicus) |
PF00258(Flavodoxin_1) | 5 | VAL A 6LEU A 36GLY A 25ALA A 26LEU A 158 | None | 1.00A | 4otyA-2arkA:undetectable | 4otyA-2arkA:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ch6 | N-ACETYL-D-GLUCOSAMINE KINASE (Homo sapiens) |
PF01869(BcrAD_BadFG) | 5 | LEU A 75SER A 76LEU A 318GLY A 110SER A 311 | None | 1.00A | 4otyA-2ch6A:undetectable | 4otyA-2ch6A:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cw6 | HYDROXYMETHYLGLUTARYL-COA LYASE,MITOCHONDRIAL (Homo sapiens) |
PF00682(HMGL-like) | 5 | LEU A 299VAL A 260GLY A 262ALA A 261SER A 316 | None | 1.06A | 4otyA-2cw6A:undetectable | 4otyA-2cw6A:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2djz | 235AA LONGHYPOTHETICALBIOTIN-[ACETYL-COA-CARBOXYLASE] LIGASE (Pyrococcushorikoshii) |
PF02237(BPL_C)PF03099(BPL_LplA_LipB) | 5 | VAL A 182LEU A 181LEU A 164GLY A 82ALA A 83 | None | 1.09A | 4otyA-2djzA:2.0 | 4otyA-2djzA:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ejb | PROBABLE AROMATICACID DECARBOXYLASE (Aquifexaeolicus) |
PF02441(Flavoprotein) | 5 | SER A 75LEU A 121VAL A 113GLY A 111LEU A 106 | None | 1.08A | 4otyA-2ejbA:undetectable | 4otyA-2ejbA:16.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2elc | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Thermusthermophilus) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | TYR A 238LEU A 74GLY A 290ALA A 289LEU A 285 | None | 1.05A | 4otyA-2elcA:undetectable | 4otyA-2elcA:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2exa | PENICILLIN-BINDINGPROTEIN 4 (Escherichiacoli) |
PF02113(Peptidase_S13) | 5 | LEU A 303LEU A 374GLY A 429ALA A 416SER A 415 | NoneNoneNoneNoneGOL A 502 (-2.3A) | 1.08A | 4otyA-2exaA:undetectable | 4otyA-2exaA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ftp | HYDROXYMETHYLGLUTARYL-COA LYASE (Pseudomonasaeruginosa) |
PF00682(HMGL-like) | 5 | VAL A 274LEU A 273GLY A 236ALA A 235SER A 290 | None | 1.07A | 4otyA-2ftpA:undetectable | 4otyA-2ftpA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ib0 | CONSERVEDHYPOTHETICAL ALANINERICH PROTEIN (Mycobacteriumtuberculosis) |
PF14530(DUF4439) | 5 | VAL A 147LEU A 148LEU A 102VAL A 104LEU A 54 | None | 0.95A | 4otyA-2ib0A:undetectable | 4otyA-2ib0A:13.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j6i | FORMATEDEHYDROGENASE ([Candida]boidinii) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | LEU A 238TYR A 194VAL A 227GLY A 171ALA A 229 | None | 1.07A | 4otyA-2j6iA:undetectable | 4otyA-2j6iA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2of3 | ZYG-9 (Caenorhabditiselegans) |
no annotation | 5 | LEU A 777LEU A 790VAL A 824ALA A 828LEU A 832 | None | 0.94A | 4otyA-2of3A:undetectable | 4otyA-2of3A:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pbl | PUTATIVEESTERASE/LIPASE/THIOESTERASE (Ruegeria sp.TM1040) |
PF07859(Abhydrolase_3) | 5 | TRP A 81GLY A 138ALA A 137SER A 136LEU A 168 | NoneNoneNoneUNL A 263 (-3.7A)None | 1.05A | 4otyA-2pblA:undetectable | 4otyA-2pblA:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ppl | PANCREATICLIPASE-RELATEDPROTEIN 1 (Homo sapiens) |
PF00151(Lipase)PF01477(PLAT) | 5 | LEU A 209VAL A 176GLY A 178ALA A 180SER A 182 | NoneNone CA A 478 ( 4.9A)NoneNone | 0.96A | 4otyA-2pplA:undetectable | 4otyA-2pplA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r7d | RIBONUCLEASE IIFAMILY PROTEIN (Deinococcusradiodurans) |
PF00773(RNB) | 5 | VAL A 120LEU A 173SER A 174GLY A 274ALA A 273 | None | 0.95A | 4otyA-2r7dA:undetectable | 4otyA-2r7dA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ru4 | ARMADILLO REPEATPROTEIN, C-TERMINALFRAGMENT, MAIIARMADILLO REPEATPROTEIN, N-TERMINALFRAGMENT, YIIM2 (syntheticconstruct) |
PF00514(Arm)PF16186(Arm_3) | 5 | SER A 110VAL B 123GLY B 127ALA B 128LEU B 132 | None | 1.01A | 4otyA-2ru4A:undetectable | 4otyA-2ru4A:11.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vos | FOLYLPOLYGLUTAMATESYNTHASE PROTEINFOLC (Mycobacteriumtuberculosis) |
PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | LEU A 103VAL A 475GLY A 478ALA A 479LEU A 483 | None | 0.91A | 4otyA-2vosA:undetectable | 4otyA-2vosA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vq0 | COAT PROTEIN (Sesbania mosaicvirus) |
PF00729(Viral_coat) | 5 | VAL A 155LEU A 158SER A 159GLY A 167SER A 138 | None | 1.03A | 4otyA-2vq0A:undetectable | 4otyA-2vq0A:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wsk | GLYCOGEN DEBRANCHINGENZYME (Escherichiacoli) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 5 | SER A 421TRP A 579GLY A 412ALA A 413LEU A 409 | None | 0.89A | 4otyA-2wskA:undetectable | 4otyA-2wskA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wua | ACETOACETYL COATHIOLASE (Helianthusannuus) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | VAL A 277LEU A 271GLY A 287ALA A 286SER A 289 | None | 1.10A | 4otyA-2wuaA:undetectable | 4otyA-2wuaA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wy0 | ANGIOTENSINOGEN (Mus musculus) |
PF00079(Serpin) | 5 | VAL C 130LEU C 128LEU C 114GLY C 143LEU C 11 | NoneNone NA C1456 ( 4.9A) NA C1456 (-4.0A)None | 0.97A | 4otyA-2wy0C:undetectable | 4otyA-2wy0C:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xec | PUTATIVE MALEATEISOMERASE (Nocardiafarcinica) |
no annotation | 5 | LEU A 158VAL A 174ALA A 178SER A 180LEU A 181 | None | 1.00A | 4otyA-2xecA:undetectable | 4otyA-2xecA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xn8 | PUTATIVE CYTOCHROMEP450 125 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | VAL A 313LEU A 415VAL A 267GLY A 269ALA A 268 | HEM A1434 ( 4.9A)NoneNoneHEM A1434 (-3.3A)HEM A1434 (-3.5A) | 1.02A | 4otyA-2xn8A:0.7 | 4otyA-2xn8A:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ylz | PHENYLACETONEMONOOXYGENASE (Thermobifidafusca) |
PF13738(Pyr_redox_3) | 5 | LEU A 146VAL A 21GLY A 23ALA A 149SER A 150 | NoneNoneFAD A 700 (-3.3A)NoneFAD A 700 (-4.9A) | 1.06A | 4otyA-2ylzA:undetectable | 4otyA-2ylzA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ynm | LIGHT-INDEPENDENTPROTOCHLOROPHYLLIDEREDUCTASEIRON-SULFURATP-BINDING PROTEIN (Prochlorococcusmarinus) |
PF00142(Fer4_NifH) | 5 | VAL A 152LEU A 153GLY A 159ALA A 162LEU A 165 | None | 1.03A | 4otyA-2ynmA:undetectable | 4otyA-2ynmA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywb | GMP SYNTHASE[GLUTAMINE-HYDROLYZING] (Thermusthermophilus) |
PF00117(GATase)PF00958(GMP_synt_C) | 6 | LEU A 225SER A 222LEU A 196VAL A 362ALA A 366LEU A 371 | None | 1.48A | 4otyA-2ywbA:undetectable | 4otyA-2ywbA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a3h | ENDOGLUCANASE (Salipaludibacillusagaradhaerens) |
PF00150(Cellulase) | 5 | LEU A 264SER A 34TRP A 56GLY A 31ALA A 260 | None | 1.10A | 4otyA-3a3hA:undetectable | 4otyA-3a3hA:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dfa | CALCIUM-DEPENDENTPROTEIN KINASECGD3_920 (Cryptosporidiumparvum) |
PF00069(Pkinase) | 5 | LEU A 244GLY A 192ALA A 191SER A 190LEU A 130 | None | 1.11A | 4otyA-3dfaA:undetectable | 4otyA-3dfaA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f3z | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE WITH A KINASEDOMAIN AND 4CALMODULIN LIKE EFHANDS (Cryptosporidiumparvum) |
PF00069(Pkinase) | 5 | LEU A 263GLY A 211ALA A 210SER A 209LEU A 149 | None | 1.08A | 4otyA-3f3zA:undetectable | 4otyA-3f3zA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h2s | PUTATIVE NADH-FLAVINREDUCTASE (Lactobacillusparacasei) |
PF13460(NAD_binding_10) | 5 | VAL A 27LEU A 28VAL A 31GLY A 7ALA A 8 | NoneNoneNoneNDP A 301 (-3.2A)None | 1.03A | 4otyA-3h2sA:undetectable | 4otyA-3h2sA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ikf | 2-C-METHYL-D-ERYTHRITOL2,4-CYCLODIPHOSPHATESYNTHASE (Burkholderiapseudomallei) |
PF02542(YgbB) | 5 | VAL A 96SER A 98GLY A 6ALA A 49LEU A 50 | None | 1.09A | 4otyA-3ikfA:undetectable | 4otyA-3ikfA:14.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3is5 | CALCIUM-DEPENDENTPROTEIN KINASE (Toxoplasmagondii) |
PF00069(Pkinase) | 5 | LEU A 374GLY A 323ALA A 322SER A 321LEU A 261 | None | 1.02A | 4otyA-3is5A:undetectable | 4otyA-3is5A:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khn | MOTB PROTEIN,PUTATIVE (Desulfovibriovulgaris) |
PF00691(OmpA) | 5 | VAL A 49SER A 51GLY A 65ALA A 66LEU A 70 | None | 0.80A | 4otyA-3khnA:undetectable | 4otyA-3khnA:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l7z | PROBABLE EXOSOMECOMPLEX EXONUCLEASE2 (Sulfolobussolfataricus) |
PF01138(RNase_PH)PF03725(RNase_PH_C) | 5 | LEU A 189LEU A 142VAL A 162ALA A 163LEU A 44 | None | 1.05A | 4otyA-3l7zA:undetectable | 4otyA-3l7zA:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nyq | MALONYL-COA LIGASE (Streptomycescoelicolor) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | VAL A 53LEU A 100LEU A 70VAL A 63LEU A 191 | None | 1.02A | 4otyA-3nyqA:undetectable | 4otyA-3nyqA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pg1 | MITOGEN-ACTIVATEDPROTEIN KINASE,PUTATIVE (MAPKINASE-LIKE PROTEIN) (Leishmaniamajor) |
PF00069(Pkinase) | 5 | LEU A 300GLY A 220ALA A 219SER A 218LEU A 159 | None | 1.10A | 4otyA-3pg1A:undetectable | 4otyA-3pg1A:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r5g | CYAB (Pseudomonasaeruginosa) |
PF00211(Guanylate_cyc) | 5 | LEU A 228TYR A 336GLY A 291ALA A 292LEU A 381 | None | 1.05A | 4otyA-3r5gA:undetectable | 4otyA-3r5gA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3re2 | PREDICTED PROTEIN (Nematostellavectensis) |
PF05053(Menin) | 5 | VAL A 378LEU A 379GLY A 410SER A 408LEU A 351 | None | 0.96A | 4otyA-3re2A:undetectable | 4otyA-3re2A:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uw2 | PHOSPHOGLUCOMUTASE/PHOSPHOMANNOMUTASEFAMILY PROTEIN (Burkholderiathailandensis) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | TYR A 338TRP A 337VAL A 82ALA A 86LEU A 91 | None | 1.02A | 4otyA-3uw2A:undetectable | 4otyA-3uw2A:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxw | ADIPONECTIN RECEPTORPROTEIN 2 (Homo sapiens) |
PF03006(HlyIII) | 5 | LEU A 320TYR A 321VAL A 356GLY A 358ALA A 359 | None | 1.06A | 4otyA-3wxwA:undetectable | 4otyA-3wxwA:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxx | ACRH (Aeromonashydrophila) |
no annotation | 5 | LEU A 130SER A 127GLY A 146ALA A 145LEU A 141 | None | 0.86A | 4otyA-3wxxA:undetectable | 4otyA-3wxxA:13.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x0y | DSZC (Rhodococcuserythropolis) |
PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N)PF08028(Acyl-CoA_dh_2) | 5 | LEU A 93TYR A 96GLY A 164ALA A 165LEU A 171 | NoneFMN A 500 (-3.4A)NoneNoneNone | 0.90A | 4otyA-3x0yA:undetectable | 4otyA-3x0yA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4czp | EXTRALONG MANGANESEPEROXIDASE (Gelatoporiasubvermispora) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 5 | VAL A 28VAL A 112GLY A 110ALA A 109LEU A 90 | None | 1.10A | 4otyA-4czpA:undetectable | 4otyA-4czpA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4doe | 1,4-BETA-GLUCANASE (Caldicellulosiruptorbescii) |
PF00759(Glyco_hydro_9) | 5 | LEU A 346VAL A 284GLY A 287ALA A 288LEU A 292 | None | 1.03A | 4otyA-4doeA:undetectable | 4otyA-4doeA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dpp | DIHYDRODIPICOLINATESYNTHASE 2,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00701(DHDPS) | 5 | VAL A 337LEU A 336LEU A 325ALA A 307LEU A 311 | None | 1.07A | 4otyA-4dppA:undetectable | 4otyA-4dppA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ej6 | PUTATIVEZINC-BINDINGDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | VAL A 31LEU A 134VAL A 137GLY A 139ALA A 140 | None | 1.05A | 4otyA-4ej6A:undetectable | 4otyA-4ej6A:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gkl | ALPHA-AMYLASE (Thermotoganeapolitana) |
PF00128(Alpha-amylase) | 5 | VAL A 100LEU A 173TYR A 141GLY A 172ALA A 171 | None | 1.10A | 4otyA-4gklA:undetectable | 4otyA-4gklA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9u | TRK SYSTEM POTASSIUMUPTAKE PROTEIN TRKH (Vibrioparahaemolyticus) |
PF02386(TrkH) | 6 | LEU A 109VAL A 79GLY A 81ALA A 83SER A 85LEU A 86 | None | 1.40A | 4otyA-4j9uA:undetectable | 4otyA-4j9uA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | LEU A 233VAL A 265GLY A 268SER A 272LEU A 273 | NoneNAD A 503 (-3.6A)NoneNoneNone | 0.82A | 4otyA-4lvcA:undetectable | 4otyA-4lvcA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m3n | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Meiothermusruber) |
PF01048(PNP_UDP_1) | 6 | VAL A 153LEU A 154LEU A 206GLY A 92ALA A 91LEU A 200 | None | 1.42A | 4otyA-4m3nA:undetectable | 4otyA-4m3nA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1m | ENOYL-ACYL CARRIERREDUCTASE (Toxoplasmagondii) |
PF13561(adh_short_C2) | 5 | LEU A 286VAL A 266GLY A 268ALA A 270LEU A 274 | None | 0.94A | 4otyA-4o1mA:undetectable | 4otyA-4o1mA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ogc | HNH ENDONUCLEASEDOMAIN PROTEIN (Actinomycesnaeslundii) |
PF01844(HNH) | 5 | LEU A 43SER A 44GLY A 15ALA A 740SER A 741 | None | 0.94A | 4otyA-4ogcA:undetectable | 4otyA-4ogcA:18.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 6 | LEU A 353SER A 354TYR A 356LEU A 508TRP A 388VAL A 524 | IBP A 601 ( 4.7A)NoneIBP A 601 (-4.5A)NoneNoneIBP A 601 ( 4.0A) | 1.49A | 4otyA-4ph9A:63.6 | 4otyA-4ph9A:99.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 6 | SER A 354TYR A 356LEU A 526ALA A 528SER A 531LEU A 532 | NoneIBP A 601 (-4.5A)NoneIBP A 601 (-3.4A)IBP A 601 ( 3.3A)IBP A 601 ( 4.9A) | 1.11A | 4otyA-4ph9A:63.6 | 4otyA-4ph9A:99.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 6 | SER A 354TYR A 356LEU A 526GLY A 527ALA A 528LEU A 532 | NoneIBP A 601 (-4.5A)NoneIBP A 601 (-3.9A)IBP A 601 (-3.4A)IBP A 601 ( 4.9A) | 1.36A | 4otyA-4ph9A:63.6 | 4otyA-4ph9A:99.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 10 | VAL A 350LEU A 353SER A 354TYR A 356LEU A 385TRP A 388VAL A 524GLY A 527ALA A 528LEU A 532 | IBP A 601 (-4.3A)IBP A 601 ( 4.7A)NoneIBP A 601 (-4.5A)NoneNoneIBP A 601 ( 4.0A)IBP A 601 (-3.9A)IBP A 601 (-3.4A)IBP A 601 ( 4.9A) | 0.59A | 4otyA-4ph9A:63.6 | 4otyA-4ph9A:99.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 10 | VAL A 350LEU A 353SER A 354TYR A 356TYR A 386TRP A 388VAL A 524ALA A 528SER A 531LEU A 532 | IBP A 601 (-4.3A)IBP A 601 ( 4.7A)NoneIBP A 601 (-4.5A)IBP A 601 (-4.8A)NoneIBP A 601 ( 4.0A)IBP A 601 (-3.4A)IBP A 601 ( 3.3A)IBP A 601 ( 4.9A) | 0.63A | 4otyA-4ph9A:63.6 | 4otyA-4ph9A:99.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 10 | VAL A 350LEU A 353SER A 354TYR A 356TYR A 386TRP A 388VAL A 524GLY A 527ALA A 528LEU A 532 | IBP A 601 (-4.3A)IBP A 601 ( 4.7A)NoneIBP A 601 (-4.5A)IBP A 601 (-4.8A)NoneIBP A 601 ( 4.0A)IBP A 601 (-3.9A)IBP A 601 (-3.4A)IBP A 601 ( 4.9A) | 0.37A | 4otyA-4ph9A:63.6 | 4otyA-4ph9A:99.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pht | TYPE II SECRETIONSYSTEM PROTEIN L (Vibriovulnificus) |
PF05134(T2SSL) | 5 | LEU X 96VAL X 62GLY X 112SER X 99LEU X 101 | None | 1.05A | 4otyA-4phtX:undetectable | 4otyA-4phtX:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rnw | NADPH DEHYDROGENASE1 (Saccharomycespastorianus) |
PF00724(Oxidored_FMN) | 5 | VAL A 384LEU A 341VAL A 367GLY A 369ALA A 368 | None | 1.10A | 4otyA-4rnwA:undetectable | 4otyA-4rnwA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rnx | NADPH DEHYDROGENASE1 (Saccharomycespastorianus) |
PF00724(Oxidored_FMN) | 5 | VAL A 134LEU A 91VAL A 117GLY A 119ALA A 118 | None | 1.08A | 4otyA-4rnxA:undetectable | 4otyA-4rnxA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tym | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Streptococcusagalactiae) |
PF01048(PNP_UDP_1) | 5 | VAL A 175LEU A 176SER A 177GLY A 114ALA A 113 | None | 1.06A | 4otyA-4tymA:undetectable | 4otyA-4tymA:16.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u8u | GLOBIN A CHAIN (Glossoscolexpaulistus) |
PF00042(Globin) | 5 | VAL A 124LEU A 68VAL A 36GLY A 34ALA A 35 | None | 1.10A | 4otyA-4u8uA:undetectable | 4otyA-4u8uA:12.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ubt | ACETYL-COAACETYLTRANSFERASEFADA5 (Mycobacteriumtuberculosis) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | VAL A 234LEU A 228GLY A 243ALA A 242SER A 245 | NoneNoneCOA A 401 ( 4.3A)COA A 401 (-3.5A)COA A 401 ( 4.0A) | 0.93A | 4otyA-4ubtA:undetectable | 4otyA-4ubtA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xyd | NITRIC-OXIDEREDUCTASE SUBUNIT B (Roseobacterdenitrificans) |
PF00115(COX1) | 5 | VAL A 344LEU A 375VAL A 426GLY A 429ALA A 430 | NoneNoneHEM A 501 ( 4.5A)NoneNone | 1.02A | 4otyA-4xydA:undetectable | 4otyA-4xydA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y5z | IMMUNOGLOBULING-BINDING PROTEINA,COAT PROTEIN (Sesbania mosaicvirus;Staphylococcusaureus) |
no annotation | 5 | VAL A 155LEU A 158SER A 159GLY A 167SER A 138 | None | 1.09A | 4otyA-4y5zA:undetectable | 4otyA-4y5zA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ync | NADPH DEHYDROGENASE1 (Saccharomycespastorianus) |
PF00724(Oxidored_FMN) | 5 | VAL A 285LEU A 242VAL A 268GLY A 270ALA A 269 | None | 1.09A | 4otyA-4yncA:undetectable | 4otyA-4yncA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zqb | NADP-DEPENDENTDEHYDROGENASE (Rhodobactersphaeroides) |
PF02826(2-Hacid_dh_C) | 5 | VAL A 176LEU A 198GLY A 149ALA A 150LEU A 154 | None | 1.08A | 4otyA-4zqbA:undetectable | 4otyA-4zqbA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b1q | U14 PROTEIN (Humanbetaherpesvirus6B) |
PF04637(Herpes_pp85) | 5 | LEU A 447VAL A 434GLY A 437ALA A 438SER A 441 | None | 0.83A | 4otyA-5b1qA:0.8 | 4otyA-5b1qA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bz4 | BETA-KETOTHIOLASE (Mycolicibacteriumsmegmatis) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | VAL A 240LEU A 234GLY A 253ALA A 252SER A 255 | None | 0.96A | 4otyA-5bz4A:undetectable | 4otyA-5bz4A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cbk | SHHTL5 (Strigahermonthica) |
PF12697(Abhydrolase_6) | 5 | LEU A 77VAL A 103GLY A 101ALA A 102SER A 98 | None | 1.10A | 4otyA-5cbkA:undetectable | 4otyA-5cbkA:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fii | PHENYLALANINE-4-HYDROXYLASE (Homo sapiens) |
PF01842(ACT) | 5 | VAL A 51LEU A 54GLY A 103ALA A 104LEU A 41 | None | 1.09A | 4otyA-5fiiA:undetectable | 4otyA-5fiiA:11.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ggy | IRON(III) ABCTRANSPORTER,PERIPLASMICIRON-COMPOUND-BINDING PROTEIN (Vibrio cholerae) |
PF01497(Peripla_BP_2) | 5 | VAL A 67LEU A 113VAL A 96GLY A 76ALA A 77 | None | 1.02A | 4otyA-5ggyA:undetectable | 4otyA-5ggyA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gju | ATP-DEPENDENT RNAHELICASE DEAD (Escherichiacoli) |
PF00270(DEAD) | 5 | LEU A 155LEU A 136VAL A 79GLY A 131LEU A 86 | None | 1.08A | 4otyA-5gjuA:undetectable | 4otyA-5gjuA:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5grm | STIMULATOR OFINTERFERON GENESPROTEIN (Rattusnorvegicus) |
no annotation | 5 | LEU A 259LEU A 330GLY A 255ALA A 256LEU A 190 | None | 1.03A | 4otyA-5grmA:undetectable | 4otyA-5grmA:19.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ikr | PROSTAGLANDIN G/HSYNTHASE 2 (Homo sapiens) |
PF00008(EGF)PF03098(An_peroxidase) | 10 | VAL A 349LEU A 352SER A 353TYR A 355LEU A 384VAL A 523GLY A 526ALA A 527SER A 530LEU A 531 | ID8 A 601 (-3.9A)ID8 A 601 (-4.1A)ID8 A 601 ( 4.7A)ID8 A 601 (-3.8A)ID8 A 601 ( 4.8A)ID8 A 601 (-3.6A)ID8 A 601 (-3.5A)ID8 A 601 (-3.5A)ID8 A 601 (-2.7A)ID8 A 601 (-3.5A) | 0.63A | 4otyA-5ikrA:34.1 | 4otyA-5ikrA:88.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ikr | PROSTAGLANDIN G/HSYNTHASE 2 (Homo sapiens) |
PF00008(EGF)PF03098(An_peroxidase) | 11 | VAL A 349LEU A 352SER A 353TYR A 355TYR A 385TRP A 387VAL A 523GLY A 526ALA A 527SER A 530LEU A 531 | ID8 A 601 (-3.9A)ID8 A 601 (-4.1A)ID8 A 601 ( 4.7A)ID8 A 601 (-3.8A)ID8 A 601 ( 3.5A)COH A 602 (-4.5A)ID8 A 601 (-3.6A)ID8 A 601 (-3.5A)ID8 A 601 (-3.5A)ID8 A 601 (-2.7A)ID8 A 601 (-3.5A) | 0.42A | 4otyA-5ikrA:34.1 | 4otyA-5ikrA:88.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5in8 | ARISTOLOCHENESYNTHASE (Aspergillusterreus) |
no annotation | 5 | VAL A 272LEU A 275SER A 276LEU A 190ALA A 286 | None | 1.00A | 4otyA-5in8A:undetectable | 4otyA-5in8A:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iva | LPS-ASSEMBLY PROTEINLPTD (Pseudomonasaeruginosa) |
PF04453(OstA_C) | 5 | SER A 408LEU A 384VAL A 406GLY A 424ALA A 423 | None | 1.09A | 4otyA-5ivaA:undetectable | 4otyA-5ivaA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jfm | ALDEHYDEDEHYDROGENASE (Rhodopseudomonaspalustris) |
PF00171(Aldedh) | 5 | VAL A 205LEU A 244VAL A 120GLY A 122LEU A 128 | None | 0.99A | 4otyA-5jfmA:undetectable | 4otyA-5jfmA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jvb | PHOSPHONATE ABCTRANSPORTER,PERIPLASMICPHOSPHONATE-BINDINGPROTEIN (Trichodesmiumerythraeum) |
no annotation | 6 | VAL A 163LEU A 177TYR A 125VAL A 104GLY A 106ALA A 174 | None | 1.29A | 4otyA-5jvbA:undetectable | 4otyA-5jvbA:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lc5 | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN4 (Bos taurus) |
PF00361(Proton_antipo_M)PF01059(Oxidored_q5_N) | 5 | LEU M 14VAL M 25ALA M 29SER M 31LEU M 32 | None | 1.08A | 4otyA-5lc5M:undetectable | 4otyA-5lc5M:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m32 | PROTEASOME SUBUNITBETA TYPE-2 (Homo sapiens) |
PF00227(Proteasome) | 5 | LEU J 4TYR J 117GLY J 135ALA J 136LEU J 140 | None | 0.93A | 4otyA-5m32J:undetectable | 4otyA-5m32J:15.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n4a | INTRAFLAGELLARTRANSPORT PROTEIN 80 (Chlamydomonasreinhardtii) |
no annotation | 5 | LEU A 371LEU A 388GLY A 393ALA A 392SER A 391 | NoneNoneGOL A 807 ( 4.7A)NoneNone | 1.02A | 4otyA-5n4aA:undetectable | 4otyA-5n4aA:9.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n7q | PUTATIVE CATHEPSIN D (Ixodes ricinus) |
no annotation | 5 | VAL A 270LEU A 281LEU A 232GLY A 301LEU A 247 | None | 1.06A | 4otyA-5n7qA:undetectable | 4otyA-5n7qA:8.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5veb | CADHERIN-6 (Homo sapiens) |
PF00028(Cadherin) | 6 | VAL X 568LEU X 527SER X 526LEU X 550GLY X 548ALA X 547 | None | 1.06A | 4otyA-5vebX:undetectable | 4otyA-5vebX:10.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xbl | CRISPR-ASSOCIATEDENDONUCLEASECAS9/CSN1 (Streptococcuspyogenes) |
PF13395(HNH_4)PF16592(Cas9_REC)PF16593(Cas9-BH)PF16595(Cas9_PI) | 5 | LEU A 9GLY A 17ALA A 50SER A 15LEU A 52 | None | 1.09A | 4otyA-5xblA:undetectable | 4otyA-5xblA:17.53 |