SIMILAR PATTERNS OF AMINO ACIDS FOR 4OTW_A_DB8A1101_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1af5 I-CREI

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		3 LEU A  41
LEU A  91
ASN A 103
 None
 0.73A 4otwA-1af5A:
undetectable		 4otwA-1af5A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		3 LEU A 317
LEU A 184
ASN A 310
 None
None
COA  A3000 (-3.3A)
 0.62A 4otwA-1aj8A:
0.7		 4otwA-1aj8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajz DIHYDROPTEROATE
SYNTHASE

(Escherichia
coli) 		PF00809
(Pterin_bind) 		3 LEU A 212
LEU A 204
ASN A 162
 None
 0.70A 4otwA-1ajzA:
0.0		 4otwA-1ajzA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amk TRIOSE PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00121
(TIM) 		3 LEU A  93
LEU A 209
ASN A  11
 None
 0.60A 4otwA-1amkA:
undetectable		 4otwA-1amkA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		3 LEU A  32
LEU A  41
ASN A  78
 None
 0.76A 4otwA-1aorA:
0.0		 4otwA-1aorA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b6u P58 KILLER CELL
INHIBITORY RECEPTOR

(Homo sapiens) 		PF00047
(ig) 		3 LEU A  97
LEU A  49
ASN A  63
 None
 0.63A 4otwA-1b6uA:
undetectable		 4otwA-1b6uA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)

(Malus domestica) 		PF00155
(Aminotran_1_2) 		3 LEU A 215
LEU A 250
ASN A 199
 None
 0.76A 4otwA-1b8gA:
0.0		 4otwA-1b8gA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 LEU A 747
LEU A 622
ASN A 715
 None
 0.76A 4otwA-1bf2A:
undetectable		 4otwA-1bf2A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjn PHOSPHOSERINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00266
(Aminotran_5) 		3 LEU A 251
LEU A 180
ASN A 259
 None
 0.67A 4otwA-1bjnA:
0.0		 4otwA-1bjnA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bud PROTEIN (ACUTOLYSIN
A)

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		3 LEU A  98
LEU A  86
ASN A  94
 None
 0.62A 4otwA-1budA:
undetectable		 4otwA-1budA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cen CELLULASE CELC

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		3 LEU A 138
LEU A 182
ASN A 175
 None
 0.72A 4otwA-1cenA:
undetectable		 4otwA-1cenA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2z DEATH DOMAIN OF
PELLE

(Drosophila
melanogaster) 		PF00531
(Death) 		3 LEU A  36
LEU A  45
ASN A  88
 None
 0.67A 4otwA-1d2zA:
undetectable		 4otwA-1d2zA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 3 LEU B 802
LEU B 634
ASN B 763
 None
 0.69A 4otwA-1ej6B:
undetectable		 4otwA-1ej6B:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 LEU A  88
LEU A 385
ASN A  96
 None
 0.66A 4otwA-1f82A:
undetectable		 4otwA-1f82A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fj1 HYBRIDOMA ANTIBODY
LA2 (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LEU B 159
LEU B 138
ASN B 155
 None
 0.68A 4otwA-1fj1B:
undetectable		 4otwA-1fj1B:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzp STAPHYLOCOCCAL
ACCESSORY REGULATOR
A

(Staphylococcus
aureus) 		no annotation 3 LEU D  95
LEU D  25
ASN D  85
 None
 0.67A 4otwA-1fzpD:
undetectable		 4otwA-1fzpD:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3j PEROXIDASE

(Coprinopsis
cinerea) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		3 LEU A  29
LEU A 102
ASN A  35
 None
 0.75A 4otwA-1h3jA:
undetectable		 4otwA-1h3jA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6u INTERNALIN H

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		3 LEU A 185
LEU A 201
ASN A 178
 None
 0.64A 4otwA-1h6uA:
undetectable		 4otwA-1h6uA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg3 TRIOSEPHOSPHATE
ISOMERASE

(Pyrococcus
woesei) 		PF00121
(TIM)
PF05690
(ThiG) 		3 LEU A  94
LEU A 180
ASN A  12
 None
None
3PP  A1226 (-3.9A)
 0.71A 4otwA-1hg3A:
undetectable		 4otwA-1hg3A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		3 LEU A  98
LEU A  86
ASN A  94
 None
 0.73A 4otwA-1htdA:
undetectable		 4otwA-1htdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htq GLUTAMINE SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		3 LEU A 301
LEU A 421
ASN A 313
 None
 0.73A 4otwA-1htqA:
undetectable		 4otwA-1htqA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1

(Saccharomyces
cerevisiae) 		PF00398
(RrnaAD) 		3 LEU A  51
LEU A  38
ASN A 129
 XE  A 344 ( 4.8A)
XE  A 342 ( 4.2A)
None
 0.69A 4otwA-1i4wA:
undetectable		 4otwA-1i4wA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia7 CELLULASE CEL9M

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9) 		3 LEU A 419
LEU A  98
ASN A  90
 None
 0.67A 4otwA-1ia7A:
undetectable		 4otwA-1ia7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im9 KILLER CELL
IMMUNOGLOBULIN-LIKE
RECEPTOR 2DL1

(Homo sapiens) 		PF00047
(ig) 		3 LEU D  97
LEU D  49
ASN D  63
 None
 0.70A 4otwA-1im9D:
undetectable		 4otwA-1im9D:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		3 LEU A 154
LEU A 100
ASN A 178
 None
None
MLZ  A 105 ( 4.3A)
 0.64A 4otwA-1iv8A:
undetectable		 4otwA-1iv8A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ivh ISOVALERYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 LEU A 247
LEU A 108
ASN A 102
 None
 0.75A 4otwA-1ivhA:
undetectable		 4otwA-1ivhA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmo HEPARIN COFACTOR II

(Homo sapiens) 		PF00079
(Serpin) 		3 LEU A 162
LEU A  95
ASN A 108
 None
 0.60A 4otwA-1jmoA:
undetectable		 4otwA-1jmoA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kob TWITCHIN

(Aplysia
californica) 		PF00069
(Pkinase) 		3 LEU A 105
LEU A 130
ASN A 179
 None
 0.60A 4otwA-1kobA:
20.8		 4otwA-1kobA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktw IOTA-CARRAGEENASE

(Alteromonas sp.
ATCC 43554) 		PF12708
(Pectate_lyase_3) 		3 LEU A 159
LEU A 220
ASN A 213
 None
 0.75A 4otwA-1ktwA:
undetectable		 4otwA-1ktwA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3d TYPE IV COLLAGEN
NONCOLLAGENOUS
DOMAIN- ALPHA2

(Bos taurus) 		PF01413
(C4) 		3 LEU C 141
LEU C  82
ASN C  43
 None
 0.75A 4otwA-1m3dC:
undetectable		 4otwA-1m3dC:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5s FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Methanosarcina
barkeri) 		PF01913
(FTR)
PF02741
(FTR_C) 		3 LEU A  84
LEU A 121
ASN A 106
 None
 0.68A 4otwA-1m5sA:
undetectable		 4otwA-1m5sA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 LEU A 286
LEU A 396
ASN A  56
 None
 0.77A 4otwA-1nj1A:
0.3		 4otwA-1nj1A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzn FISSION PROTEIN
FIS1P

(Homo sapiens) 		PF14852
(Fis1_TPR_N)
PF14853
(Fis1_TPR_C) 		3 LEU A 116
LEU A 100
ASN A 108
 None
 0.69A 4otwA-1nznA:
undetectable		 4otwA-1nznA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og3 T-CELL
ECTO-ADP-RIBOSYLTRAN
SFERASE 2

(Rattus
norvegicus) 		PF01129
(ART) 		3 LEU A  75
LEU A  43
ASN A  87
 None
None
NAD  A1227 (-4.5A)
 0.68A 4otwA-1og3A:
undetectable		 4otwA-1og3A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3w CYSTEINE DESULFURASE

(Escherichia
coli) 		no annotation 3 LEU B 317
LEU B 357
ASN B 302
 None
 0.76A 4otwA-1p3wB:
undetectable		 4otwA-1p3wB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		3 LEU A 578
LEU A 554
ASN A 563
 None
 0.75A 4otwA-1pxyA:
undetectable		 4otwA-1pxyA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		3 LEU A 612
LEU A 400
ASN A 203
 None
 0.76A 4otwA-1pxyA:
undetectable		 4otwA-1pxyA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		3 LEU A 349
LEU A  91
ASN A 357
 None
 0.74A 4otwA-1q50A:
undetectable		 4otwA-1q50A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q98 THIOL PEROXIDASE

(Haemophilus
influenzae) 		PF08534
(Redoxin) 		3 LEU A 147
LEU A 136
ASN A  49
 None
 0.64A 4otwA-1q98A:
undetectable		 4otwA-1q98A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 LEU A 326
LEU A 267
ASN A 225
 None
FAD  A1656 (-4.3A)
None
 0.75A 4otwA-1qlbA:
undetectable		 4otwA-1qlbA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r30 BIOTIN SYNTHASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		3 LEU A 206
LEU A 174
ASN A 153
 None
None
DTB  A 502 ( 3.7A)
 0.72A 4otwA-1r30A:
undetectable		 4otwA-1r30A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s35 SPECTRIN BETA CHAIN,
ERYTHROCYTE

(Homo sapiens) 		PF00435
(Spectrin) 		3 LEU A1251
LEU A1225
ASN A1259
 None
 0.75A 4otwA-1s35A:
undetectable		 4otwA-1s35A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptomyces
sp. R61) 		PF00144
(Beta-lactamase) 		3 LEU A  83
LEU A  91
ASN A 163
 None
 0.77A 4otwA-1sdeA:
undetectable		 4otwA-1sdeA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A

([Haemophilus]
ducreyi) 		PF03498
(CDtoxinA) 		3 LEU A  87
LEU A 145
ASN A 131
 None
 0.61A 4otwA-1sr4A:
undetectable		 4otwA-1sr4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suu DNA GYRASE SUBUNIT A

(Borreliella
burgdorferi) 		PF03989
(DNA_gyraseA_C) 		3 LEU A 705
LEU A 615
ASN A 605
 None
 0.75A 4otwA-1suuA:
undetectable		 4otwA-1suuA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy6 T-CELL SURFACE
GLYCOPROTEIN CD3
GAMMA/EPSILON CHAIN

(Homo sapiens) 		PF16680
(Ig_4)
PF16681
(Ig_5) 		3 LEU A 199
LEU A  22
ASN A  55
 None
 0.77A 4otwA-1sy6A:
undetectable		 4otwA-1sy6A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szn ALPHA-GALACTOSIDASE

(Trichoderma
reesei) 		PF16499
(Melibiase_2) 		3 LEU A 358
LEU A 238
ASN A 334
 None
None
NAG  A 800 (-1.8A)
 0.59A 4otwA-1sznA:
undetectable		 4otwA-1sznA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcd TRIOSEPHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00121
(TIM) 		3 LEU A  94
LEU A 210
ASN A  12
 None
 0.64A 4otwA-1tcdA:
undetectable		 4otwA-1tcdA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2z HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Saccharomyces
cerevisiae) 		PF08123
(DOT1) 		3 LEU A 239
LEU A 215
ASN A 263
 None
 0.45A 4otwA-1u2zA:
undetectable		 4otwA-1u2zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udx THE GTP-BINDING
PROTEIN OBG

(Thermus
thermophilus) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1)
PF09269
(DUF1967) 		3 LEU A 281
LEU A 290
ASN A 277
 None
 0.73A 4otwA-1udxA:
undetectable		 4otwA-1udxA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 LEU A 223
LEU A 246
ASN A 256
 None
 0.75A 4otwA-1ulzA:
0.8		 4otwA-1ulzA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upn ECHOVIRUS 11 COAT
PROTEIN VP3

(Enterovirus B) 		PF00073
(Rhv) 		3 LEU C 224
LEU C  43
ASN C 105
 None
 0.70A 4otwA-1upnC:
undetectable		 4otwA-1upnC:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyp BETA-FRUCTOSIDASE

(Thermotoga
maritima) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 LEU A 265
LEU A 257
ASN A 211
 SO4  A1435 (-4.2A)
None
None
 0.75A 4otwA-1uypA:
2.6		 4otwA-1uypA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		3 LEU A  77
LEU A  82
ASN A 130
 None
 0.55A 4otwA-1v0bA:
24.4		 4otwA-1v0bA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v47 ATP SULFURYLASE

(Thermus
thermophilus) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 LEU A 336
LEU A 211
ASN A 165
 None
 0.59A 4otwA-1v47A:
undetectable		 4otwA-1v47A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		3 LEU B 391
LEU B 424
ASN B 383
 None
 0.58A 4otwA-1wa5B:
undetectable		 4otwA-1wa5B:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		3 LEU A 178
LEU A 158
ASN A 121
 None
 0.75A 4otwA-1wb0A:
undetectable		 4otwA-1wb0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 LEU A 479
LEU A 367
ASN A 432
 None
 0.55A 4otwA-1xb7A:
undetectable		 4otwA-1xb7A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Vibrio cholerae) 		PF01408
(GFO_IDH_MocA) 		3 LEU A 211
LEU A 188
ASN A 182
 None
 0.72A 4otwA-1xeaA:
undetectable		 4otwA-1xeaA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xly SHE2P

(Saccharomyces
cerevisiae) 		PF11435
(She2p) 		3 LEU A 223
LEU A  35
ASN A  66
 None
 0.77A 4otwA-1xlyA:
undetectable		 4otwA-1xlyA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		no annotation 3 LEU B 476
LEU B 614
ASN B 426
 None
 0.72A 4otwA-1xnjB:
undetectable		 4otwA-1xnjB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Staphylococcus
aureus) 		PF04131
(NanE) 		3 LEU A 146
LEU A 166
ASN A 182
 None
None
PO4  A 502 (-4.2A)
 0.54A 4otwA-1y0eA:
undetectable		 4otwA-1y0eA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yaa ASPARTATE
AMINOTRANSFERASE

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		3 LEU A 315
LEU A 233
ASN A  82
 None
 0.69A 4otwA-1yaaA:
undetectable		 4otwA-1yaaA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z14 VP2

(Rodent
protoparvovirus
1) 		PF00740
(Parvo_coat) 		3 LEU A 258
LEU A  73
ASN A 504
 None
 0.75A 4otwA-1z14A:
undetectable		 4otwA-1z14A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		3 LEU A  91
LEU A 141
ASN A  99
 None
 0.71A 4otwA-1z26A:
undetectable		 4otwA-1z26A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		3 LEU A 737
LEU A 767
ASN A 749
 None
 0.75A 4otwA-1z26A:
undetectable		 4otwA-1z26A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		3 LEU X 274
LEU X 306
ASN X 300
 None
 0.72A 4otwA-1z3iX:
undetectable		 4otwA-1z3iX:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvu TOPOISOMERASE IV
SUBUNIT A

(Escherichia
coli) 		PF00521
(DNA_topoisoIV)
PF03989
(DNA_gyraseA_C) 		3 LEU A 621
LEU A 576
ASN A 615
 None
 0.72A 4otwA-1zvuA:
undetectable		 4otwA-1zvuA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY

(Thermotoga
maritima) 		PF00294
(PfkB) 		3 LEU A   7
LEU A  74
ASN A  84
 None
 0.71A 4otwA-2ajrA:
undetectable		 4otwA-2ajrA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens) 		PF00079
(Serpin) 		3 LEU I 270
LEU I 292
ASN I 405
 None
 0.72A 4otwA-2b4xI:
undetectable		 4otwA-2b4xI:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)

(Black beetle
virus) 		PF01829
(Peptidase_A6) 		3 LEU A 256
LEU A 319
ASN A 293
 None
 0.66A 4otwA-2bbvA:
undetectable		 4otwA-2bbvA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF13088
(BNR_2) 		3 LEU A 537
LEU A 461
ASN A 488
 None
 0.62A 4otwA-2bf6A:
0.9		 4otwA-2bf6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c49 SUGAR KINASE MJ0406

(Methanocaldococcus
jannaschii) 		PF00294
(PfkB) 		3 LEU A  62
LEU A 254
ASN A 155
 None
 0.59A 4otwA-2c49A:
undetectable		 4otwA-2c49A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crf RAN BINDING PROTEIN
3

(Homo sapiens) 		PF00638
(Ran_BP1) 		3 LEU A  56
LEU A  36
ASN A  84
 None
 0.73A 4otwA-2crfA:
undetectable		 4otwA-2crfA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cs5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 4

(Homo sapiens) 		PF00595
(PDZ) 		3 LEU A  56
LEU A 100
ASN A  62
 None
 0.71A 4otwA-2cs5A:
undetectable		 4otwA-2cs5A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddt SPHINGOMYELIN
PHOSPHODIESTERASE

(Bacillus cereus) 		PF03372
(Exo_endo_phos) 		3 LEU A 128
LEU A  78
ASN A  92
 None
 0.72A 4otwA-2ddtA:
undetectable		 4otwA-2ddtA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dl2 PROTEIN (MHC CLASS I
NK CELL RECEPTOR
PRECURSOR (P58
NATURAL KILLER CELL
RECEPTOR CLONE
CL-43))

(Homo sapiens) 		PF00047
(ig) 		3 LEU A  97
LEU A  49
ASN A  63
 None
 0.73A 4otwA-2dl2A:
undetectable		 4otwA-2dl2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4m HA-17

(Clostridium
botulinum) 		PF05588
(Botulinum_HA-17) 		3 LEU C  68
LEU C   8
ASN C  12
 None
 0.77A 4otwA-2e4mC:
undetectable		 4otwA-2e4mC:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 LEU A 366
LEU A 137
ASN A 417
 None
 0.44A 4otwA-2e6kA:
undetectable		 4otwA-2e6kA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		3 LEU A 291
LEU A 279
ASN A 287
 None
 0.64A 4otwA-2erqA:
undetectable		 4otwA-2erqA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8t ARGONAUTE PROTEIN

(Aquifex
aeolicus) 		PF02171
(Piwi) 		3 LEU A 396
LEU A 438
ASN A 458
 None
 0.73A 4otwA-2f8tA:
undetectable		 4otwA-2f8tA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fdb FIBROBLAST GROWTH
FACTOR 8 ISOFORM B

(Homo sapiens) 		PF00167
(FGF) 		3 LEU M 106
LEU M  56
ASN M  74
 None
 0.73A 4otwA-2fdbM:
undetectable		 4otwA-2fdbM:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		3 LEU A 323
LEU A 258
ASN A 264
 None
 0.67A 4otwA-2fuqA:
undetectable		 4otwA-2fuqA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ga8 HYPOTHETICAL 39.9
KDA PROTEIN

(Saccharomyces
cerevisiae) 		PF07728
(AAA_5) 		3 LEU A 291
LEU A 202
ASN A  22
 None
 0.74A 4otwA-2ga8A:
undetectable		 4otwA-2ga8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2guu ODCASE

(Plasmodium
vivax) 		PF00215
(OMPdecase) 		3 LEU A  66
LEU A 160
ASN A 152
 None
 0.77A 4otwA-2guuA:
undetectable		 4otwA-2guuA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gy5 ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF10430
(Ig_Tie2_1) 		3 LEU A 296
LEU A  42
ASN A  97
 None
 0.65A 4otwA-2gy5A:
undetectable		 4otwA-2gy5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho9 CHEMOTAXIS PROTEIN
CHEW

(Escherichia
coli) 		PF01584
(CheW) 		3 LEU A  20
LEU A 150
ASN A  92
 None
 0.59A 4otwA-2ho9A:
undetectable		 4otwA-2ho9A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 122
LEU A 127
ASN A 175
 None
 0.55A 4otwA-2hw6A:
19.5		 4otwA-2hw6A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ice COMPLEMENT C3 BETA
CHAIN

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		3 LEU A 164
LEU A 108
ASN A 131
 None
 0.62A 4otwA-2iceA:
undetectable		 4otwA-2iceA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8)
PF16920
(TPKR_C2) 		3 LEU A 212
LEU A 232
ASN A 253
 None
 0.65A 4otwA-2ifgA:
undetectable		 4otwA-2ifgA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imj HYPOTHETICAL PROTEIN
DUF1348

(Pseudomonas
protegens) 		PF07080
(DUF1348) 		3 LEU A  81
LEU A  77
ASN A 110
 None
ACT  A 201 ( 4.6A)
None
 0.77A 4otwA-2imjA:
1.8		 4otwA-2imjA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imr HYPOTHETICAL PROTEIN
DR_0824

(Deinococcus
radiodurans) 		PF01979
(Amidohydro_1) 		3 LEU A 126
LEU A 170
ASN A  95
 None
 0.69A 4otwA-2imrA:
undetectable		 4otwA-2imrA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9l LACTADHERIN

(Mus musculus) 		PF00754
(F5_F8_type_C) 		3 LEU A  40
LEU A 149
ASN A 120
 None
 0.73A 4otwA-2l9lA:
undetectable		 4otwA-2l9lA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mri 26S PROTEASOME
REGULATORY SUBUNIT
RPN9

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		3 LEU A 194
LEU A 233
ASN A 186
 None
 0.67A 4otwA-2mriA:
undetectable		 4otwA-2mriA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mri 26S PROTEASOME
REGULATORY SUBUNIT
RPN9

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		3 LEU A 217
LEU A 258
ASN A 229
 None
 0.69A 4otwA-2mriA:
undetectable		 4otwA-2mriA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx8 TRNA-SPECIFIC
ADENOSINE DEAMINASE

(Streptococcus
pyogenes) 		PF14437
(MafB19-deam) 		3 LEU A  84
LEU A 129
ASN A 135
 None
 0.73A 4otwA-2nx8A:
undetectable		 4otwA-2nx8A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0h DNA PACKAGING
PROTEIN GP17

(Escherichia
virus T4) 		PF03237
(Terminase_6) 		3 LEU A  90
LEU A 228
ASN A 222
 None
 0.75A 4otwA-2o0hA:
undetectable		 4otwA-2o0hA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2g DIENELACTONE
HYDROLASE

(Trichormus
variabilis) 		PF01738
(DLH) 		3 LEU A  93
LEU A  67
ASN A  52
 None
None
SO4  A 223 (-3.3A)
 0.68A 4otwA-2o2gA:
undetectable		 4otwA-2o2gA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		3 LEU X 101
LEU X  89
ASN X  40
 HMD  X 400 (-4.2A)
None
None
 0.44A 4otwA-2pmoX:
1.7		 4otwA-2pmoX:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjj MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Novosphingobium
aromaticivorans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 273
LEU A 295
ASN A 265
 None
 0.76A 4otwA-2qjjA:
undetectable		 4otwA-2qjjA:
22.09