SIMILAR PATTERNS OF AMINO ACIDS FOR 4OTI_A_MI1A1001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1koa TWITCHIN

(Caenorhabditis
elegans) 		PF00069
(Pkinase)
PF07679
(I-set) 		7 LEU A5948
GLY A5949
GLY A5951
GLY A5954
VAL A5956
ALA A5969
LYS A5971
 None
 0.57A 4otiA-1koaA:
20.4		 4otiA-1koaA:
26.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		8 LEU A 164
GLY A 165
GLY A 167
VAL A 172
ALA A 185
LYS A 187
LEU A 301
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.0A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
ADP  A 810 (-4.7A)
None
 0.53A 4otiA-1q8yA:
20.2		 4otiA-1q8yA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
GLY A 596
GLY A 601
VAL A 603
ALA A 621
VAL A 654
LEU A 799
 STI  A   3 ( 3.8A)
None
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
STI  A   3 (-4.4A)
 0.57A 4otiA-1t46A:
14.0		 4otiA-1t46A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 344
GLY A 345
GLY A 347
GLY A 350
VAL A 352
ALA A 367
LYS A 369
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
None
None
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
 0.58A 4otiA-1u59A:
20.1		 4otiA-1u59A:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 344
GLY A 345
GLY A 350
VAL A 352
ALA A 367
LYS A 369
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
None
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
STU  A 100 (-4.5A)
 0.55A 4otiA-1u59A:
20.1		 4otiA-1u59A:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 GLY A  16
VAL A  18
ALA A  30
VAL A  63
LEU A 132
ALA A 142
ASP A 143
 None
 0.63A 4otiA-1v0bA:
21.0		 4otiA-1v0bA:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		7 GLY A  19
GLY A  21
GLY A  24
ALA A  39
LYS A  41
LEU A 138
ASP A 154
 CKI  A 300 ( 3.8A)
None
None
CKI  A 300 (-3.6A)
None
CKI  A 300 (-4.4A)
CKI  A 300 (-4.4A)
 0.62A 4otiA-2csnA:
12.6		 4otiA-2csnA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU X  17
GLY X  18
GLY X  20
GLY X  23
VAL X  25
ALA X  37
LYS X  39
VAL X  67
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
None
None
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.4A)
 0.64A 4otiA-2dq7X:
20.8		 4otiA-2dq7X:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU X  17
GLY X  18
GLY X  20
GLY X  23
VAL X  25
LYS X  39
LEU X 137
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
None
None
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.88A 4otiA-2dq7X:
20.8		 4otiA-2dq7X:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU X  17
GLY X  18
GLY X  23
VAL X  25
ALA X  37
LYS X  39
VAL X  67
LEU X 137
ALA X 147
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
None
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.62A 4otiA-2dq7X:
20.8		 4otiA-2dq7X:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU X  17
GLY X  18
GLY X  23
VAL X  25
LYS X  39
LEU X 137
ALA X 147
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
None
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
STU  X 902 (-3.6A)
 0.93A 4otiA-2dq7X:
20.8		 4otiA-2dq7X:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 GLY A  35
GLY A  37
GLY A  40
VAL A  42
ALA A  55
LYS A  57
LEU A 158
 STU  A 400 (-3.3A)
None
None
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
STU  A 400 ( 4.6A)
 0.57A 4otiA-2gcdA:
23.0		 4otiA-2gcdA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
GLY A 276
GLY A 279
VAL A 281
ALA A 293
VAL A 323
ALA A 403
ASP A 404
 QUE  A   1 (-3.9A)
None
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 ( 4.5A)
None
 0.84A 4otiA-2hckA:
20.2		 4otiA-2hckA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
GLY A 276
GLY A 279
VAL A 281
ALA A 293
VAL A 323
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
None
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.82A 4otiA-2hckA:
20.2		 4otiA-2hckA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 248
GLY A 249
GLY A 251
GLY A 254
VAL A 256
ALA A 269
VAL A 299
LEU A 370
ALA A 380
 GIN  A 600 ( 4.6A)
None
None
None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.6A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.51A 4otiA-2hz0A:
19.6		 4otiA-2hz0A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		8 GLY A 429
GLY A 431
GLY A 434
VAL A 436
ALA A 452
LYS A 454
VAL A 484
LEU A 553
 4ST  A1687 (-3.1A)
None
None
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
4ST  A1687 (-4.4A)
 0.67A 4otiA-2j0jA:
20.2		 4otiA-2j0jA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		7 LEU A  25
GLY A  26
GLY A  28
VAL A  33
ALA A  46
LYS A  48
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.0A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
ATP  A 381 ( 4.8A)
 0.56A 4otiA-2phkA:
23.7		 4otiA-2phkA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		7 GLY A 491
GLY A 493
GLY A 496
VAL A 498
ALA A 509
LYS A 511
LEU A 656
 5ID  A1800 (-3.5A)
None
None
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
5ID  A1800 (-4.5A)
 0.53A 4otiA-2vuwA:
14.6		 4otiA-2vuwA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  52
GLY A  53
GLY A  55
VAL A  60
ALA A  73
LYS A  75
LEU A 171
ALA A 184
ASP A 185
 DKI  A1338 (-3.8A)
DKI  A1338 (-3.3A)
None
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
None
DKI  A1338 (-4.9A)
DKI  A1338 (-3.1A)
DKI  A1338 (-3.8A)
 0.78A 4otiA-2w4oA:
17.4		 4otiA-2w4oA:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU C  55
GLY C  56
GLY C  58
GLY C  61
VAL C  63
ALA C  76
LYS C  78
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
ANP  C   2 (-3.8A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
 0.55A 4otiA-2wtkC:
17.4		 4otiA-2wtkC:
28.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  68
GLY A  69
GLY A  71
GLY A  74
VAL A  76
ALA A  92
VAL A 125
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 ( 4.1A)
None
None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
 0.65A 4otiA-2z7rA:
26.3		 4otiA-2z7rA:
37.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  97
GLY A  98
GLY A 100
GLY A 103
VAL A 105
ALA A 121
VAL A 156
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
None
None
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
None
 0.49A 4otiA-3a62A:
25.9		 4otiA-3a62A:
40.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  59
GLY A  60
GLY A  62
GLY A  65
VAL A  67
ALA A  80
LYS A  82
VAL A 113
LEU A 186
 STU  A   1 (-3.8A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-3.4A)
STU  A   1 ( 4.2A)
None
STU  A   1 (-4.4A)
 0.58A 4otiA-3fmeA:
16.2		 4otiA-3fmeA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 833
GLY A 834
GLY A 839
VAL A 841
ALA A 859
VAL A 892
LEU A1029
 8ST  A2001 ( 4.7A)
None
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
None
 0.50A 4otiA-3hngA:
19.2		 4otiA-3hngA:
29.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  82
GLY A  83
VAL A  90
ALA A 103
LYS A 105
LEU A 206
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A 542 ( 4.6A)
J60  A 540 ( 3.6A)
 0.63A 4otiA-3hztA:
19.6		 4otiA-3hztA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  82
GLY A  83
GLY A  85
GLY A  88
VAL A  90
ALA A 103
LEU A 205
 ANP  A 610 ( 4.5A)
ANP  A 610 (-3.5A)
ANP  A 610 (-2.9A)
ANP  A 610 (-4.5A)
ANP  A 610 (-3.9A)
ANP  A 610 ( 3.7A)
None
 0.48A 4otiA-3igoA:
21.4		 4otiA-3igoA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 171
GLY A 172
GLY A 174
VAL A 179
ALA A 192
LYS A 194
VAL A 224
ALA A 303
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
None
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
None
FEF  A 668 (-4.7A)
FEF  A 668 ( 4.0A)
 0.71A 4otiA-3mtlA:
15.6		 4otiA-3mtlA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 171
GLY A 172
VAL A 179
ALA A 192
LYS A 194
VAL A 224
LEU A 293
ALA A 303
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
None
FEF  A 668 (-4.7A)
FEF  A 668 (-4.2A)
FEF  A 668 ( 4.0A)
 0.64A 4otiA-3mtlA:
15.6		 4otiA-3mtlA:
26.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  49
GLY A  50
GLY A  52
GLY A  55
VAL A  57
ALA A  70
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
XFE  A 351 (-4.6A)
 0.41A 4otiA-3mvjA:
33.4		 4otiA-3mvjA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  49
GLY A  50
GLY A  52
GLY A  55
VAL A  57
ALA A  70
VAL A 104
PHE A 327
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 (-4.4A)
 0.53A 4otiA-3mvjA:
33.4		 4otiA-3mvjA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  49
GLY A  50
GLY A  52
VAL A  57
ALA A  70
LYS A  72
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 (-4.6A)
 0.45A 4otiA-3mvjA:
33.4		 4otiA-3mvjA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  49
GLY A  50
GLY A  52
VAL A  57
ALA A  70
LYS A  72
VAL A 104
PHE A 327
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.4A)
 0.58A 4otiA-3mvjA:
33.4		 4otiA-3mvjA:
34.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		8 GLY A  30
GLY A  32
GLY A  35
VAL A  37
ALA A  49
LYS A  51
VAL A  82
ALA A 161
 ADP  A 314 (-3.3A)
ADP  A 314 (-3.0A)
None
ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
None
 0.78A 4otiA-3nizA:
22.4		 4otiA-3nizA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		8 GLY A  30
GLY A  32
GLY A  35
VAL A  37
ALA A  49
VAL A  82
LEU A 151
ALA A 161
 ADP  A 314 (-3.3A)
ADP  A 314 (-3.0A)
None
ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
ADP  A 314 (-4.6A)
None
 0.63A 4otiA-3nizA:
22.4		 4otiA-3nizA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 192
GLY A 193
GLY A 198
VAL A 200
ALA A 213
VAL A 247
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
None
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
AMP  A 577 (-4.8A)
 0.59A 4otiA-3nyoA:
32.0		 4otiA-3nyoA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 GLY A 558
GLY A 560
GLY A 563
VAL A 565
ALA A 576
LYS A 578
LEU A 683
 STU  A   1 (-3.2A)
None
None
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.3A)
 0.56A 4otiA-3ppzA:
21.1		 4otiA-3ppzA:
26.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  83
GLY A  85
GLY A  88
VAL A  90
ALA A 103
LEU A 207
ALA A 217
PHE A 370
 NM7  A 416 (-3.0A)
None
None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
NM7  A 416 (-3.3A)
 0.72A 4otiA-3qfvA:
29.3		 4otiA-3qfvA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  50
GLY A  51
GLY A  56
VAL A  58
ALA A  71
VAL A  98
LEU A 173
 I85  A 350 (-3.7A)
I85  A 350 (-3.5A)
None
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
None
None
 0.55A 4otiA-3sheA:
19.7		 4otiA-3sheA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
GLY A 485
GLY A 487
GLY A 490
VAL A 492
ALA A 512
LEU A 630
ALA A 640
ASP A 641
 07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
None
None
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
07J  A   1 (-4.7A)
 0.79A 4otiA-3tt0A:
20.0		 4otiA-3tt0A:
27.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		9 LEU A 361
GLY A 362
GLY A 367
VAL A 369
ALA A 382
LYS A 384
LEU A 486
ALA A 496
PHE A 644
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
None
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
None
 0.43A 4otiA-3txoA:
25.2		 4otiA-3txoA:
46.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uto TWITCHIN

(Caenorhabditis
elegans) 		PF00041
(fn3)
PF00069
(Pkinase)
PF07679
(I-set) 		7 LEU A 162
GLY A 163
GLY A 165
GLY A 168
VAL A 170
ALA A 183
LYS A 185
 None
 0.44A 4otiA-3utoA:
20.7		 4otiA-3utoA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
GLY A 841
GLY A 846
VAL A 848
ALA A 866
VAL A 899
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
None
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.8A)
 0.31A 4otiA-3vidA:
18.9		 4otiA-3vidA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
GLY A 841
GLY A 846
VAL A 848
ALA A 866
VAL A 899
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
None
None
B49  A2000 (-3.5A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.5A)
 0.37A 4otiA-4agdA:
18.5		 4otiA-4agdA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		8 LEU A  22
GLY A  23
GLY A  28
VAL A  30
ALA A  43
LYS A  45
LEU A 146
ALA A 156
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
None
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.68A 4otiA-4cfhA:
25.2		 4otiA-4cfhA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
GLY A 619
GLY A 622
VAL A 624
ALA A 653
LYS A 655
 None
None
None
None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
 0.55A 4otiA-4ckrA:
18.8		 4otiA-4ckrA:
27.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		10 LEU A 663
GLY A 666
GLY A 669
VAL A 671
ALA A 684
LYS A 686
VAL A 721
LEU A 789
ALA A 799
PHE A 946
 AGS  A1985 (-4.2A)
AGS  A1985 (-2.9A)
AGS  A1985 (-4.1A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 (-4.8A)
 0.57A 4otiA-4crsA:
26.0		 4otiA-4crsA:
77.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
GLY A  27
GLY A  29
VAL A  34
ALA A  47
VAL A  79
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-3.2A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-4.7A)
ATP  A 401 (-4.6A)
 0.58A 4otiA-4fg8A:
22.0		 4otiA-4fg8A:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 LEU A 377
GLY A 378
GLY A 380
GLY A 383
VAL A 385
ALA A 400
VAL A 433
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-3.5A)
None
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-4.8A)
MG  A 702 ( 3.1A)
 0.56A 4otiA-4fl3A:
20.0		 4otiA-4fl3A:
19.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 156
GLY A 157
GLY A 159
GLY A 162
VAL A 164
ALA A 177
PHE A 438
 0XZ  A 501 ( 4.1A)
GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.1A)
0XZ  A 501 (-3.8A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
0XZ  A 501 (-4.8A)
 0.59A 4otiA-4gv1A:
36.0		 4otiA-4gv1A:
46.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 156
GLY A 157
GLY A 162
VAL A 164
ALA A 177
ASP A 292
PHE A 438
 0XZ  A 501 ( 4.1A)
GOL  A 505 ( 3.4A)
0XZ  A 501 (-3.8A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
0XZ  A 501 ( 3.4A)
0XZ  A 501 (-4.8A)
 0.50A 4otiA-4gv1A:
36.0		 4otiA-4gv1A:
46.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 156
GLY A 157
GLY A 162
VAL A 164
ALA A 177
LYS A 179
ASP A 292
 0XZ  A 501 ( 4.1A)
GOL  A 505 ( 3.4A)
0XZ  A 501 (-3.8A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
GOL  A 503 ( 2.8A)
0XZ  A 501 ( 3.4A)
 0.53A 4otiA-4gv1A:
36.0		 4otiA-4gv1A:
46.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 828
GLY A 829
GLY A 831
GLY A 834
VAL A 836
ALA A 853
VAL A 884
LEU A 956
ALA A 966
 19S  A1201 (-3.9A)
19S  A1201 (-3.7A)
19S  A1201 ( 4.3A)
19S  A1201 ( 4.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.55A 4otiA-4hviA:
19.7		 4otiA-4hviA:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 828
GLY A 831
VAL A 836
ALA A 853
LYS A 855
VAL A 884
LEU A 956
ALA A 966
 19S  A1201 (-3.9A)
19S  A1201 ( 4.3A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.70A 4otiA-4hviA:
19.7		 4otiA-4hviA:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 132
GLY A 133
GLY A 135
GLY A 138
VAL A 140
ALA A 156
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
None
None
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-4.6A)
 0.62A 4otiA-4id7A:
20.5		 4otiA-4id7A:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 132
GLY A 133
GLY A 135
GLY A 138
VAL A 140
ALA A 156
LYS A 158
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
None
None
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
 0.59A 4otiA-4id7A:
20.5		 4otiA-4id7A:
25.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
GLY A 479
GLY A 484
VAL A 486
ALA A 506
LEU A 624
ALA A 634
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.4A)
ACP  A 801 (-3.6A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-4.4A)
None
 0.56A 4otiA-4k33A:
3.1		 4otiA-4k33A:
30.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  78
GLY A  79
GLY A  81
GLY A  84
VAL A  86
ALA A  99
LYS A 101
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-3.6A)
STU  A 601 (-3.9A)
None
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
STU  A 601 (-4.7A)
 0.58A 4otiA-4mvfA:
22.1		 4otiA-4mvfA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY B  31
GLY B  33
GLY B  36
VAL B  38
ALA B  51
LEU B 151
ALA B 161
 ADP  B 500 ( 3.8A)
ADP  B 500 (-3.3A)
None
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-4.7A)
None
 0.54A 4otiA-4o27B:
18.0		 4otiA-4o27B:
28.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		9 LEU A 627
GLY A 628
GLY A 630
GLY A 633
VAL A 635
ALA A 648
LYS A 650
LEU A 753
PHE A 910
 None
 0.72A 4otiA-4otdA:
44.6		 4otiA-4otdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		10 LEU A 627
GLY A 628
GLY A 633
VAL A 635
ALA A 648
LYS A 650
VAL A 685
LEU A 753
ALA A 763
PHE A 910
 None
 0.45A 4otiA-4otdA:
44.6		 4otiA-4otdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  24
GLY A  25
GLY A  30
VAL A  32
ALA A  45
LEU A 148
ALA A 158
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
None
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.2A)
STU  A 601 ( 3.8A)
 0.54A 4otiA-4rewA:
25.0		 4otiA-4rewA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
GLY A 622
VAL A 624
ALA A 642
LYS A 644
VAL A 675
 P30  A1001 (-3.8A)
None
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
 0.53A 4otiA-4rt7A:
14.1		 4otiA-4rt7A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
GLY A 622
VAL A 624
ALA A 642
VAL A 675
LEU A 818
 P30  A1001 (-3.8A)
None
None
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.6A)
 0.45A 4otiA-4rt7A:
14.1		 4otiA-4rt7A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		9 LEU A 192
GLY A 193
GLY A 195
GLY A 198
VAL A 200
ALA A 213
LYS A 215
VAL A 247
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.4A)
None
None
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
SGV  A 601 (-3.0A)
 0.67A 4otiA-4tnbA:
23.2		 4otiA-4tnbA:
25.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		9 LEU A 104
GLY A 105
GLY A 107
GLY A 110
VAL A 112
ALA A 125
VAL A 159
LEU A 228
PHE A 382
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-3.8A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
ATP  A 501 (-4.5A)
ATP  A 501 (-4.5A)
 0.57A 4otiA-4wb7A:
33.7		 4otiA-4wb7A:
32.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		8 LEU A 104
GLY A 105
GLY A 107
VAL A 112
ALA A 125
LYS A 127
VAL A 159
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
ATP  A 501 (-4.5A)
 0.59A 4otiA-4wb7A:
33.7		 4otiA-4wb7A:
32.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
GLY A 194
GLY A 199
VAL A 201
ALA A 214
VAL A 248
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
None
ANW  A 601 (-3.4A)
None
ANW  A 601 (-4.9A)
 0.61A 4otiA-4wboA:
32.4		 4otiA-4wboA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 GLY A 470
GLY A 475
VAL A 477
ALA A 488
LYS A 490
LEU A 595
ALA A 605
ASP A 606
 4CV  A 801 ( 3.9A)
None
None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
4CV  A 801 (-3.5A)
 0.81A 4otiA-4yffA:
20.6		 4otiA-4yffA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
GLY A 194
GLY A 199
VAL A 201
ALA A 214
VAL A 248
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.4A)
None
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
None
None
 0.52A 4otiA-4yhjA:
31.6		 4otiA-4yhjA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 166
GLY A 168
GLY A 171
VAL A 173
ALA A 186
LYS A 188
LEU A 294
 4E1  A 505 (-3.5A)
4E1  A 505 ( 4.9A)
None
4E1  A 505 (-4.5A)
4E1  A 505 (-3.5A)
4E1  A 505 (-2.7A)
None
 0.55A 4otiA-4yljA:
20.3		 4otiA-4yljA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  34
GLY A  35
GLY A  37
GLY A  40
VAL A  42
ALA A  55
LYS A  57
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-2.8A)
None
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
ADP  A 506 (-4.7A)
 0.63A 4otiA-4ysjA:
24.1		 4otiA-4ysjA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
GLY A 490
VAL A 492
ALA A 512
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
None
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.46A 4otiA-5a46A:
20.1		 4otiA-5a46A:
29.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 GLY A  63
GLY A  65
VAL A  70
ALA A  83
LYS A  85
VAL A 116
LEU A 185
ALA A 195
 5RC  A4000 ( 4.3A)
5RC  A4000 ( 3.9A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
None
5RC  A4000 ( 3.9A)
 0.71A 4otiA-5es1A:
24.6		 4otiA-5es1A:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
GLY A 600
GLY A 605
VAL A 607
ALA A 625
VAL A 658
LEU A 825
 748  A1001 (-3.8A)
None
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
748  A1001 (-4.3A)
 0.51A 4otiA-5grnA:
12.5		 4otiA-5grnA:
27.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		8 LEU A  20
GLY A  21
GLY A  23
VAL A  28
ALA A  41
LYS A  43
VAL A  74
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-2.8A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
ADP  A 301 ( 4.8A)
 0.56A 4otiA-5hu3A:
23.8		 4otiA-5hu3A:
29.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		8 LEU A  20
GLY A  21
GLY A  23
VAL A  28
ALA A  41
VAL A  74
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-2.8A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.58A 4otiA-5hu3A:
23.8		 4otiA-5hu3A:
29.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  57
GLY A  60
VAL A  65
ALA A  77
LYS A  79
VAL A 109
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-4.4A)
 0.62A 4otiA-5i3oA:
21.2		 4otiA-5i3oA:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
GLY A  23
GLY A  28
VAL A  30
ALA A  43
LEU A 146
ALA A 156
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
992  A 602 ( 3.8A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.49A 4otiA-5isoA:
25.2		 4otiA-5isoA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
GLY A  23
VAL A  30
ALA A  43
LYS A  45
LEU A 146
ALA A 156
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.30A 4otiA-5isoA:
25.2		 4otiA-5isoA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  23
GLY A  28
VAL A  30
ALA A  43
VAL A  74
LEU A 143
ALA A 153
 None
None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.38A 4otiA-5j5tA:
23.2		 4otiA-5j5tA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  23
VAL A  30
ALA A  43
LYS A  45
VAL A  74
LEU A 143
ALA A 153
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.49A 4otiA-5j5tA:
23.2		 4otiA-5j5tA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 8 GLY A 359
GLY A 361
GLY A 364
VAL A 366
ALA A 379
VAL A 413
LEU A 482
PHE A 700
 ANP  A 801 ( 4.1A)
ANP  A 801 (-3.1A)
None
ANP  A 801 (-4.7A)
ANP  A 801 ( 3.9A)
ANP  A 801 ( 4.9A)
ANP  A 801 (-4.8A)
ANP  A 801 (-4.4A)
 0.63A 4otiA-5nclA:
27.3		 4otiA-5nclA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 542
GLY A 543
GLY A 545
GLY A 548
VAL A 550
ALA A 565
LYS A 567
 7YS  A9001 (-4.1A)
7YS  A9001 ( 4.2A)
None
None
7YS  A9001 (-4.2A)
7YS  A9001 (-3.3A)
None
 0.63A 4otiA-5u6bA:
20.0		 4otiA-5u6bA:
27.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  99
GLY A 101
GLY A 104
VAL A 106
ALA A 119
LEU A 221
PHE A 384
 None
 0.42A 4otiA-5u7qA:
30.5		 4otiA-5u7qA:
33.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  99
GLY A 101
VAL A 106
ALA A 119
LEU A 221
ALA A 231
PHE A 384
 None
 0.57A 4otiA-5u7qA:
30.5		 4otiA-5u7qA:
33.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  99
VAL A 106
ALA A 119
VAL A 153
LEU A 221
ALA A 231
PHE A 384
 None
 0.53A 4otiA-5u7qA:
30.5		 4otiA-5u7qA:
33.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 GLY A 198
GLY A 200
GLY A 203
VAL A 205
ALA A 218
VAL A 255
LEU A 324
 QRW  A 601 ( 4.5A)
QRW  A 601 (-3.6A)
QRW  A 601 (-4.2A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
None
 0.57A 4otiA-5uuuA:
33.5		 4otiA-5uuuA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 7 GLY A 216
GLY A 218
GLY A 221
VAL A 223
ALA A 236
LYS A 238
LEU A 342
 None
PO4  A 602 (-3.5A)
None
HRM  A 601 ( 4.9A)
HRM  A 601 (-3.5A)
HRM  A 601 (-3.3A)
None
 0.59A 4otiA-5y86A:
14.2		 4otiA-5y86A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 8 GLY A 219
GLY A 221
GLY A 224
VAL A 226
ALA A 237
LYS A 239
VAL A 272
ASP A 358
 DL1  A 601 ( 4.1A)
None
None
None
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
DL1  A 601 ( 4.8A)
DL1  A 601 (-3.1A)
 0.82A 4otiA-6bfnA:
17.1		 4otiA-6bfnA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 9 LEU A 366
GLY A 367
GLY A 369
GLY A 372
VAL A 374
ALA A 388
LYS A 390
ASP A 502
PHE A 649
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-3.4A)
EE4  A 701 (-4.1A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
DMS  A 702 ( 3.1A)
None
 0.72A 4otiA-6c0tA:
23.5		 4otiA-6c0tA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 8 LEU A 366
GLY A 367
GLY A 372
VAL A 374
ALA A 388
LYS A 390
VAL A 422
PHE A 649
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.1A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
None
None
 0.70A 4otiA-6c0tA:
23.5		 4otiA-6c0tA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
GLY A 882
GLY A 884
GLY A 887
VAL A 889
ALA A 906
VAL A 938
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-3.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
 0.41A 4otiA-6c7yA:
19.0		 4otiA-6c7yA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
GLY A 882
GLY A 884
VAL A 889
ALA A 906
LYS A 908
VAL A 938
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-3.3A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
 0.46A 4otiA-6c7yA:
19.0		 4otiA-6c7yA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 GLY A  67
VAL A  74
ALA A  87
LYS A  89
VAL A 120
LEU A 189
ALA A 199
 None
 0.53A 4otiA-6c9dA:
23.5		 4otiA-6c9dA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 GLY A 172
GLY A 177
VAL A 179
ALA A 192
VAL A 249
LEU A 319
ALA A 329
 F6J  A 501 ( 3.9A)
FMT  A 503 (-3.6A)
F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
None
F6J  A 501 (-4.5A)
F6J  A 501 ( 4.0A)
 0.51A 4otiA-6cmjA:
24.3		 4otiA-6cmjA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 GLY A 172
VAL A 179
ALA A 192
LYS A 194
VAL A 249
LEU A 319
ALA A 329
 F6J  A 501 ( 3.9A)
F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 (-2.9A)
None
F6J  A 501 (-4.5A)
F6J  A 501 ( 4.0A)
 0.49A 4otiA-6cmjA:
24.3		 4otiA-6cmjA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 8 LEU A 169
GLY A 170
GLY A 172
GLY A 175
VAL A 177
ALA A 191
LYS A 193
LEU A 297
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.5A)
None
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
None
 0.52A 4otiA-6fylA:
21.2		 4otiA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 7 LEU A 169
GLY A 170
GLY A 175
VAL A 177
ALA A 191
LYS A 193
VAL A 227
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
None
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
None
 0.62A 4otiA-6fylA:
21.2		 4otiA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 7 LEU A 167
GLY A 168
GLY A 173
VAL A 175
ALA A 189
LYS A 191
LEU A 295
 EAQ  A 501 (-3.9A)
None
None
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-4.9A)
 0.50A 4otiA-6fyoA:
21.0		 4otiA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 8 LEU A 167
GLY A 168
GLY A 170
GLY A 173
VAL A 175
ALA A 189
LYS A 191
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.9A)
None
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
None
 0.63A 4otiA-6fyvA:
21.4		 4otiA-6fyvA:
undetectable