SIMILAR PATTERNS OF AMINO ACIDS FOR 4OR0_B_NPSB603_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1

(Trypanosoma
brucei) 		PF00211
(Guanylate_cyc) 		5 ARG A1118
LEU A1114
VAL A1098
LEU A1116
LEU A1086
 None
 1.24A 4or0B-1fx2A:
undetectable		 4or0B-1fx2A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 LEU A 242
ARG A 243
LEU A 274
LEU A 453
LEU A 304
 None
 1.25A 4or0B-1loxA:
undetectable		 4or0B-1loxA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5z AMPA RECEPTOR
INTERACTING PROTEIN

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 LEU A  22
ARG A 104
VAL A  25
LEU A 100
LEU A  72
 None
 1.21A 4or0B-1m5zA:
undetectable		 4or0B-1m5zA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p5q FK506-BINDING
PROTEIN 4

(Homo sapiens) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF07719
(TPR_2) 		5 LEU A 204
VAL A 170
LEU A 249
LEU A 200
LEU A 247
 None
 1.28A 4or0B-1p5qA:
undetectable		 4or0B-1p5qA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 41 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		5 LEU D 201
ARG D 202
SER D 205
LEU D 221
LEU D 235
 None
 1.20A 4or0B-1sxjD:
2.5		 4or0B-1sxjD:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 LEU A 198
SER A 202
TRP A 214
VAL A 343
LEU A 347
 None
None
None
None
DKA  A1002 ( 4.3A)
 0.80A 4or0B-1tf0A:
44.7		 4or0B-1tf0A:
76.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 LEU A 198
SER A 202
VAL A 343
LEU A 347
LEU A 481
 None
None
None
DKA  A1002 ( 4.3A)
None
 0.79A 4or0B-1tf0A:
44.7		 4or0B-1tf0A:
76.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj7 ARGININOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		5 LEU A  62
SER A  41
VAL A  96
LEU A  99
LEU A 103
 None
 1.12A 4or0B-1tj7A:
1.6		 4or0B-1tj7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj7 ARGININOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		5 LEU A  62
VAL A  96
LEU A  99
LEU A  65
LEU A 103
 None
 1.22A 4or0B-1tj7A:
1.6		 4or0B-1tj7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0d DNA FRAGMENTATION
FACTOR 40 KDA
SUBUNIT

(Mus musculus) 		PF09230
(DFF40) 		5 ARG A 168
LEU A 171
ARG A 172
SER A 175
LEU A 193
 None
 1.12A 4or0B-1v0dA:
0.9		 4or0B-1v0dA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2a GLUTATHIONE
TRANSFERASE GST1-6

(Anopheles dirus) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 ARG A 185
LEU A  17
VAL A 198
LEU A   7
LEU A 158
 None
 1.27A 4or0B-1v2aA:
undetectable		 4or0B-1v2aA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Mus musculus) 		no annotation 5 LEU A 260
VAL A 221
LEU A 225
LEU A 274
LEU A 257
 None
 1.28A 4or0B-1wwlA:
undetectable		 4or0B-1wwlA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389

(Mycobacterium
tuberculosis) 		PF13523
(Acetyltransf_8) 		5 LEU A  82
ARG A  33
VAL A  47
LEU A  50
LEU A  56
 None
 1.18A 4or0B-1yk3A:
undetectable		 4or0B-1yk3A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 274
VAL A 228
LEU A 224
LEU A 201
LEU A 276
 None
 1.24A 4or0B-2ag1A:
undetectable		 4or0B-2ag1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dl2 PROTEIN (MHC CLASS I
NK CELL RECEPTOR
PRECURSOR (P58
NATURAL KILLER CELL
RECEPTOR CLONE
CL-43))

(Homo sapiens) 		PF00047
(ig) 		5 LEU A  39
ARG A  41
VAL A  24
LEU A  49
LEU A  10
 None
 1.16A 4or0B-2dl2A:
undetectable		 4or0B-2dl2A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9x DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2

(Homo sapiens) 		PF05916
(Sld5) 		5 LEU B  48
VAL B  15
LEU B  60
LEU B  33
LEU B  52
 None
 1.32A 4or0B-2e9xB:
undetectable		 4or0B-2e9xB:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f31 DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		5 LEU A 156
ARG A 210
LEU A 186
LEU A 153
LEU A 182
 None
 1.33A 4or0B-2f31A:
1.7		 4or0B-2f31A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 LEU A 596
SER A 684
VAL A 734
LEU A 593
LEU A 727
 None
 1.25A 4or0B-2fgeA:
undetectable		 4or0B-2fgeA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		5 LEU A 404
VAL A 397
LEU A 419
LEU A 405
LEU A 423
 None
 1.22A 4or0B-2gsnA:
undetectable		 4or0B-2gsnA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8o GERANYLTRANSTRANSFER
ASE

(Agrobacterium
fabrum) 		PF00348
(polyprenyl_synt) 		5 ARG A  89
LEU A  92
SER A  96
LEU A  88
LEU A 323
 None
 1.29A 4or0B-2h8oA:
3.1		 4or0B-2h8oA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjs USG-1 PROTEIN
HOMOLOG

(Pseudomonas
aeruginosa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A 327
SER A 128
VAL A 112
LEU A 223
LEU A 330
 None
 1.23A 4or0B-2hjsA:
undetectable		 4or0B-2hjsA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoq PUTATIVE
HAD-HYDROLASE PH1655

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		5 LEU A 133
VAL A  96
LEU A 217
LEU A 131
LEU A 103
 None
 1.13A 4or0B-2hoqA:
2.0		 4or0B-2hoqA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A 322
VAL A 303
LEU A 327
LEU A 298
LEU A 348
 None
 1.28A 4or0B-2id5A:
undetectable		 4or0B-2id5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE

(Pseudomonas
putida) 		PF01323
(DSBA) 		5 SER A  96
VAL A 129
SER A 130
LEU A 133
LEU A 144
 None
 0.89A 4or0B-2imeA:
undetectable		 4or0B-2imeA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jpi HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF09981
(DUF2218) 		5 LEU A  78
SER A   6
LEU A  56
LEU A  87
LEU A  48
 None
 1.27A 4or0B-2jpiA:
undetectable		 4or0B-2jpiA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k5g UNCHARACTERIZED
PROTEIN

(Bordetella
parapertussis) 		PF08327
(AHSA1) 		5 ARG A  25
LEU A 129
LEU A  48
LEU A  27
LEU A  38
 None
 1.28A 4or0B-2k5gA:
undetectable		 4or0B-2k5gA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lw7 HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00458
(WHEP-TRS)
PF03129
(HGTP_anticodon) 		5 LEU A 155
VAL A 136
LEU A 132
LEU A 139
LEU A  88
 None
 1.32A 4or0B-2lw7A:
undetectable		 4or0B-2lw7A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mvu ACTINORHODIN
POLYKETIDE SYNTHASE
ACYL CARRIER PROTEIN

(Streptomyces
coelicolor) 		PF00550
(PP-binding) 		5 ARG A  72
LEU A  75
LEU A   4
LEU A  31
LEU A   5
 None
 1.25A 4or0B-2mvuA:
undetectable		 4or0B-2mvuA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocd L-ASPARAGINASE I

(Vibrio cholerae) 		PF00710
(Asparaginase) 		5 ARG A 157
VAL A 193
SER A 190
LEU A 189
LEU A 177
 None
 1.20A 4or0B-2ocdA:
undetectable		 4or0B-2ocdA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0d RHO
GTPASE-ACTIVATING
PROTEIN 9

(Homo sapiens) 		PF00169
(PH) 		5 LEU A 430
VAL A 350
LEU A 329
LEU A 385
LEU A 403
 None
 1.27A 4or0B-2p0dA:
undetectable		 4or0B-2p0dA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qru UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF07859
(Abhydrolase_3) 		5 LEU A  48
ARG A 101
VAL A 258
LEU A 261
LEU A 265
 None
EDO  A 278 ( 3.8A)
None
None
None
 1.23A 4or0B-2qruA:
undetectable		 4or0B-2qruA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjb UNCHARACTERIZED
PROTEIN

(Shigella
flexneri) 		PF07063
(DUF1338) 		5 LEU A 261
ARG A 256
LEU A 310
LEU A 298
LEU A 389
 None
 1.23A 4or0B-2rjbA:
undetectable		 4or0B-2rjbA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsd CHIR AB1

(Gallus gallus) 		PF13895
(Ig_2) 		5 LEU A  40
ARG A  47
VAL A  25
LEU A  13
LEU A  11
 None
 1.23A 4or0B-2vsdA:
undetectable		 4or0B-2vsdA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Homo sapiens) 		PF04869
(Uso1_p115_head) 		5 ARG A  73
LEU A  69
VAL A 138
LEU A 126
LEU A  86
 None
 1.26A 4or0B-2w3cA:
2.5		 4or0B-2w3cA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynt GIM-1 PROTEIN

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		5 LEU B  72
VAL B 259
LEU B 217
LEU B  54
LEU B 205
 None
 1.16A 4or0B-2yntB:
undetectable		 4or0B-2yntB:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz6 UPF0502 PROTEIN
PSPTO_2686

(Pseudomonas
syringae group
genomosp. 3) 		PF04337
(DUF480) 		5 ARG A 151
LEU A 148
VAL A 104
LEU A 153
LEU A 110
 None
 1.15A 4or0B-3bz6A:
undetectable		 4or0B-3bz6A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		5 LEU A 241
ARG A 242
LEU A 273
LEU A 452
LEU A 303
 None
 1.32A 4or0B-3d3lA:
2.1		 4or0B-3d3lA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 218
VAL A 159
LEU A 165
LEU A 123
LEU A 132
 None
 1.24A 4or0B-3e7oA:
undetectable		 4or0B-3e7oA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq2 GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Bos taurus) 		PF04869
(Uso1_p115_head) 		5 ARG A  73
LEU A  69
VAL A 138
LEU A 126
LEU A  86
 None
 1.11A 4or0B-3gq2A:
2.5		 4or0B-3gq2A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv9 PROTEIN FIMX

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		5 ARG A 457
LEU A 480
LEU A 451
LEU A 481
LEU A 447
 GOL  A 906 ( 4.5A)
None
None
None
None
 1.12A 4or0B-3hv9A:
undetectable		 4or0B-3hv9A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix7 UNCHARACTERIZED
PROTEIN TTHA0540

(Thermus
thermophilus) 		no annotation 5 LEU A 225
VAL A 149
SER A 148
LEU A 150
LEU A 243
 None
 1.03A 4or0B-3ix7A:
undetectable		 4or0B-3ix7A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
DNA REPLICATION
COMPLEX GINS PROTEIN
SLD5

(Saccharomyces
cerevisiae) 		PF05916
(Sld5)
PF16922
(SLD5_C) 		5 ARG B 182
LEU B 181
VAL D 276
LEU B 168
LEU B 160
 None
 1.28A 4or0B-3jc7B:
undetectable		 4or0B-3jc7B:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF01823
(MACPF) 		5 LEU A 190
VAL A  96
LEU A 205
LEU A  73
LEU A 102
 None
 1.28A 4or0B-3kk7A:
undetectable		 4or0B-3kk7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		5 ARG A  45
LEU A  48
SER A  52
LEU A  44
LEU A 277
 None
 1.31A 4or0B-3m0gA:
2.0		 4or0B-3m0gA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqz UNCHARACTERIZED
CONSERVED PROTEIN
DUF1054

(Leptospirillum
rubarum) 		PF06335
(DUF1054) 		5 LEU A  44
ARG A  43
VAL A  65
LEU A  13
LEU A  48
 None
 1.31A 4or0B-3mqzA:
undetectable		 4or0B-3mqzA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN

(Triatoma virus) 		PF08762
(CRPV_capsid) 		5 LEU A 217
SER A  63
VAL A 133
LEU A 119
LEU A  68
 None
 1.32A 4or0B-3napA:
undetectable		 4or0B-3napA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngo CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 LEU A 354
VAL A 191
LEU A 536
LEU A 332
LEU A 538
 None
 0.92A 4or0B-3ngoA:
undetectable		 4or0B-3ngoA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re1 UROPORPHYRINOGEN-III
SYNTHETASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02602
(HEM4) 		5 LEU A 174
VAL A 188
LEU A 213
LEU A  32
LEU A 208
 None
 1.22A 4or0B-3re1A:
undetectable		 4or0B-3re1A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli) 		no annotation 5 LEU M 120
VAL M 257
LEU M  97
LEU M 153
LEU M 124
 None
 1.27A 4or0B-3rkoM:
3.1		 4or0B-3rkoM:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A 139
VAL A 321
LEU A 258
LEU A 142
LEU A 151
 None
 1.15A 4or0B-3tz6A:
undetectable		 4or0B-3tz6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A 142
VAL A 302
LEU A 285
LEU A 139
LEU A 276
 None
 1.26A 4or0B-3tz6A:
undetectable		 4or0B-3tz6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B

(Homo sapiens;
Mus musculus;
Rattus
norvegicus) 		PF02828
(L27)
PF09045
(L27_2)
PF09060
(L27_N) 		5 LEU A 237
VAL A 154
LEU A 155
LEU A 147
LEU A 170
 None
 1.09A 4or0B-3uitA:
undetectable		 4or0B-3uitA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		5 LEU A 890
VAL A 905
LEU A 826
LEU A 920
LEU A 828
 None
 1.08A 4or0B-3ummA:
2.7		 4or0B-3ummA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9u PUTATIVE LIPASE

(Proteus
mirabilis) 		PF00561
(Abhydrolase_1) 		5 LEU A 157
SER A 109
VAL A 132
LEU A 222
LEU A 234
 None
 1.29A 4or0B-3w9uA:
undetectable		 4or0B-3w9uA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkh CELLOBIOSE
2-EPIMERASE

(Rhodothermus
marinus) 		PF07221
(GlcNAc_2-epim) 		5 LEU A 202
ARG A 210
VAL A 273
LEU A 274
LEU A 266
 None
 1.27A 4or0B-3wkhA:
undetectable		 4or0B-3wkhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8l UNCHARACTERIZED
PROTEIN YHFS

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 LEU A  83
VAL A  95
LEU A 115
LEU A 168
LEU A 113
 None
 1.30A 4or0B-4j8lA:
undetectable		 4or0B-4j8lA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 127
VAL A  91
SER A  92
LEU A  95
LEU A 124
 None
 1.03A 4or0B-4m7eA:
undetectable		 4or0B-4m7eA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1

(Saccharomyces
cerevisiae) 		no annotation 5 ARG A 505
VAL A 538
SER A 537
LEU A 812
LEU A 532
 None
 1.21A 4or0B-4n5cA:
2.3		 4or0B-4n5cA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE

(Geobacillus
stearothermophilus) 		PF16499
(Melibiase_2) 		5 LEU A 334
ARG A 335
VAL A  63
LEU A 121
LEU A  55
 None
 1.24A 4or0B-4nxkA:
undetectable		 4or0B-4nxkA:
19.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		5 LEU A 198
ARG A 199
SER A 202
VAL A 343
LEU A 481
 None
 0.88A 4or0B-4po0A:
49.7		 4or0B-4po0A:
71.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		5 LEU A 198
SER A 202
VAL A 343
LEU A 347
LEU A 481
 None
None
None
NPS  A 602 ( 4.2A)
None
 0.85A 4or0B-4po0A:
49.7		 4or0B-4po0A:
71.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6i T-CELL SURFACE
GLYCOPROTEIN CD4

(Homo sapiens) 		PF00047
(ig)
PF05790
(C2-set) 		5 LEU C  74
SER C  79
VAL C 168
LEU C   5
LEU C  95
 None
 1.22A 4or0B-4q6iC:
undetectable		 4or0B-4q6iC:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r10 PROTEIN HUMPBACK-2

(Caenorhabditis
elegans) 		PF00514
(Arm) 		5 LEU A 428
VAL A 468
LEU A 506
LEU A 425
LEU A 440
 None
 1.21A 4or0B-4r10A:
3.0		 4or0B-4r10A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r10 PROTEIN HUMPBACK-2

(Caenorhabditis
elegans) 		PF00514
(Arm) 		5 LEU A 542
VAL A 503
LEU A 562
LEU A 547
LEU A 560
 None
 1.27A 4or0B-4r10A:
3.0		 4or0B-4r10A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6u COG5
COG7

(Kluyveromyces
lactis) 		PF10392
(COG5)
no annotation 		5 LEU A  31
VAL B 138
LEU B 135
LEU B 187
LEU B 131
 None
 1.26A 4or0B-4u6uA:
undetectable		 4or0B-4u6uA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnr LEUCINE-RICH-REPEAT
PROTEIN

(Methanosarcina
barkeri) 		PF08477
(Roc)
PF16095
(COR) 		5 LEU A 341
SER A 470
VAL A 372
LEU A 477
LEU A 338
 None
 1.20A 4or0B-4wnrA:
undetectable		 4or0B-4wnrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs SIMILARITY TO
HELICASE MOT1

(Encephalitozoon
cuniculi) 		no annotation 5 LEU C 285
SER C 297
VAL C 247
LEU C 265
LEU C 262
 None
 1.23A 4or0B-4wzsC:
undetectable		 4or0B-4wzsC:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zej METALLO-BETA-LACTAMA
SE

(Pseudomonas
stutzeri) 		no annotation 5 LEU A  36
VAL A 196
LEU A 154
LEU A  18
LEU A 148
 None
 1.24A 4or0B-4zejA:
undetectable		 4or0B-4zejA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwv PUTATIVE
AMINOTRANSFERASE

(Actinomadura
melliaura) 		PF01041
(DegT_DnrJ_EryC1) 		5 LEU A 280
VAL A 345
SER A 346
LEU A 347
LEU A 105
 None
 1.03A 4or0B-4zwvA:
undetectable		 4or0B-4zwvA:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		6 LEU A 197
SER A 201
VAL A 342
LEU A 346
LEU A 454
LEU A 480
 None
None
None
CZE  A 613 ( 3.8A)
None
None
 0.95A 4or0B-5dqfA:
50.2		 4or0B-5dqfA:
73.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 SER A 201
VAL A 342
SER A 343
LEU A 346
LEU A 480
 None
None
None
CZE  A 613 ( 3.8A)
None
 0.90A 4or0B-5dqfA:
50.2		 4or0B-5dqfA:
73.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6t CAPSID

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		5 LEU A 474
VAL A 231
LEU A 234
LEU A 409
LEU A 430
 None
 1.19A 4or0B-5e6tA:
undetectable		 4or0B-5e6tA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g23 TYPE-IV LIKE PILIN
TTHA1219

(Thermus
thermophilus) 		no annotation 5 LEU A 205
VAL A 147
LEU A 178
LEU A 209
LEU A 226
 None
 1.09A 4or0B-5g23A:
undetectable		 4or0B-5g23A:
17.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		5 SER A 202
TRP A 214
VAL A 343
SER A 344
LEU A 347
 None
 1.04A 4or0B-5ghkA:
46.3		 4or0B-5ghkA:
76.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		5 SER A 202
VAL A 343
SER A 344
LEU A 347
LEU A 481
 None
 1.07A 4or0B-5ghkA:
46.3		 4or0B-5ghkA:
76.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj3 PERIPLASMIC BINDING
PROTEIN

(Roseiflexus sp.
RS-1) 		PF01497
(Peripla_BP_2) 		5 LEU A 314
ARG A 323
VAL A 305
LEU A 299
LEU A 238
 None
 1.23A 4or0B-5gj3A:
undetectable		 4or0B-5gj3A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 LEU A 336
VAL A 282
LEU A 299
LEU A 341
LEU A 347
 None
 1.25A 4or0B-5gz4A:
undetectable		 4or0B-5gz4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 LEU B1022
ARG B1099
LEU B1074
LEU B1019
LEU B1070
 None
 1.24A 4or0B-5hb4B:
undetectable		 4or0B-5hb4B:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 LEU B1029
SER B1110
LEU B1052
LEU B1103
LEU B1043
 None
 1.10A 4or0B-5hb4B:
undetectable		 4or0B-5hb4B:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 LEU A 129
ARG A 130
SER A 364
LEU A 365
LEU A 134
 None
 1.32A 4or0B-5jm7A:
4.0		 4or0B-5jm7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l94 CYTOCHROME P450

(Bacillus
megaterium) 		PF00067
(p450) 		5 LEU A 240
SER A 165
LEU A  80
LEU A 151
LEU A 194
 None
 1.18A 4or0B-5l94A:
undetectable		 4or0B-5l94A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 LEU A 689
SER A 692
LEU A 709
LEU A 535
LEU A 693
 None
 1.33A 4or0B-5me3A:
undetectable		 4or0B-5me3A:
19.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 5 ARG A 194
ARG A 198
SER A 201
TRP A 213
LEU A 454
 None
 1.31A 4or0B-5oriA:
51.8		 4or0B-5oriA:
91.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 7 LEU A 197
ARG A 198
SER A 201
TRP A 213
ARG A 217
LEU A 454
LEU A 480
 None
 0.93A 4or0B-5oriA:
51.8		 4or0B-5oriA:
91.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 9 LEU A 197
ARG A 198
SER A 201
TRP A 213
VAL A 342
SER A 343
LEU A 346
LEU A 454
LEU A 480
 None
 0.62A 4or0B-5oriA:
51.8		 4or0B-5oriA:
91.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t58 KLLA0C15939P
KLLA0D15741P

(Kluyveromyces
lactis) 		PF08202
(MIS13)
PF08641
(Mis14) 		5 LEU D 294
VAL N  58
LEU N  55
LEU D 272
LEU N  51
 None
 1.25A 4or0B-5t58D:
undetectable		 4or0B-5t58D:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjf ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT

(Gracilaria
chilensis) 		PF00502
(Phycobilisome) 		5 LEU B  97
ARG B  37
SER B  41
VAL A  30
LEU A  23
 None
NA  B 213 (-3.0A)
None
None
None
 1.31A 4or0B-5tjfB:
undetectable		 4or0B-5tjfB:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		5 LEU A1429
SER A1162
VAL A1168
LEU A1624
LEU A1164
 None
 1.28A 4or0B-5u1sA:
5.1		 4or0B-5u1sA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E

(Micromonospora
griseorubida) 		PF00067
(p450) 		5 LEU A 231
VAL A 146
LEU A 110
LEU A 232
LEU A 205
 HEM  A 401 (-3.4A)
None
None
None
None
 1.30A 4or0B-5uhuA:
undetectable		 4or0B-5uhuA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Homo sapiens) 		no annotation 5 LEU A 642
SER A 587
LEU A 590
LEU A 641
LEU A 655
 None
 1.26A 4or0B-5wp6A:
undetectable		 4or0B-5wp6A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1u UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 ARG A 315
LEU A 316
SER A 219
LEU A 285
LEU A 225
 None
 1.22A 4or0B-5x1uA:
undetectable		 4or0B-5x1uA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xh9 EXTRACELLULAR
INVERTASE

(Aspergillus
kawachii) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 LEU A 394
SER A 341
VAL A 576
LEU A 584
LEU A 395
 None
 1.32A 4or0B-5xh9A:
undetectable		 4or0B-5xh9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		5 LEU C 320
SER C 324
VAL C 291
LEU C 287
LEU C 316
 None
 1.22A 4or0B-5y3rC:
undetectable		 4or0B-5y3rC:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydl PKS

(Streptomyces
sp. CNQ431) 		no annotation 5 LEU A 254
ARG A 263
VAL A 247
LEU A 227
LEU A 222
 None
 1.28A 4or0B-5ydlA:
undetectable		 4or0B-5ydlA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 5 LEU A 322
VAL A 209
SER A 210
LEU A 213
LEU A 345
 None
 0.82A 4or0B-5yvsA:
undetectable		 4or0B-5yvsA:
8.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 LEU A 198
SER A 202
VAL A 343
SER A 344
LEU A 347
LEU A 481
 None
 0.89A 4or0B-5yxeA:
undetectable		 4or0B-5yxeA:
78.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbk PUTATIVE CYTOKININ
RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A 175
VAL A   8
LEU A  38
LEU A 178
LEU A  36
 None
 1.00A 4or0B-5zbkA:
undetectable		 4or0B-5zbkA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6al5 B-LYMPHOCYTE ANTIGEN
CD19

(Homo sapiens) 		no annotation 5 LEU A 225
VAL A  87
LEU A 196
LEU A  68
LEU A  82
 None
 1.26A 4or0B-6al5A:
undetectable		 4or0B-6al5A:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE

(Legionella
pneumophila) 		no annotation 5 LEU A 147
ARG A 155
LEU A 184
LEU A 106
LEU A 165
 None
 1.17A 4or0B-6bs7A:
undetectable		 4or0B-6bs7A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 5 ARG B 303
VAL B 288
SER B 250
LEU B 286
LEU B 256
 None
 1.28A 4or0B-6f0kB:
undetectable		 4or0B-6f0kB:
10.12