SIMILAR PATTERNS OF AMINO ACIDS FOR 4OR0_B_NPSB602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akc ASPARTATE
AMINOTRANSFERASE

(Gallus gallus) 		PF00155
(Aminotran_1_2) 		5 ALA A 190
ALA A 239
LEU A 208
LEU A 252
VAL A 250
 None
 1.14A 4or0B-1akcA:
0.0		 4or0B-1akcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 ARG A 382
ALA A 383
ALA A 386
LEU A 345
VAL A 352
 None
 0.99A 4or0B-1fc4A:
undetectable		 4or0B-1fc4A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h5y HISF

(Pyrobaculum
aerophilum) 		PF00977
(His_biosynth) 		5 ALA A 207
LEU A 225
SER A 236
LEU A 235
VAL A 240
 PO4  A 302 ( 4.9A)
None
None
None
None
 1.16A 4or0B-1h5yA:
undetectable		 4or0B-1h5yA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsj FUSION PROTEIN
CONSISTING OF
STAPHYLOCOCCUS
ACCESSORY REGULATOR
PROTEIN R AND
MALTOSE BINDING
PROTEIN

(Escherichia
coli;
Staphylococcus
aureus) 		PF01547
(SBP_bac_1) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.13A 4or0B-1hsjA:
0.1		 4or0B-1hsjA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2

(Drosophila
melanogaster;
Escherichia
coli) 		no annotation 5 ALA P 263
ALA P 104
LEU P 102
LEU P 261
VAL P 260
 None
 1.17A 4or0B-1r6zP:
undetectable		 4or0B-1r6zP:
23.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 ALA A 210
LEU A 327
LYS A 351
SER A 480
LEU A 481
VAL A 482
 DKA  A1002 (-3.3A)
DKA  A1001 (-4.1A)
DKA  A1002 (-2.6A)
DKA  A1002 (-3.4A)
None
DKA  A1002 (-4.2A)
 1.01A 4or0B-1tf0A:
44.7		 4or0B-1tf0A:
76.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		8 ARG A 209
ALA A 210
ALA A 213
LEU A 327
LEU A 347
SER A 480
LEU A 481
VAL A 482
 DKA  A1001 ( 4.6A)
DKA  A1002 (-3.3A)
DKA  A1001 ( 4.0A)
DKA  A1001 (-4.1A)
DKA  A1002 ( 4.3A)
DKA  A1002 (-3.4A)
None
DKA  A1002 (-4.2A)
 0.73A 4or0B-1tf0A:
44.7		 4or0B-1tf0A:
76.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4c MALTOSE BINDING
PROTEIN FUSED WITH
DESIGNED HELICAL
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.17A 4or0B-1y4cA:
0.2		 4or0B-1y4cA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq3 SUCCINATE
DEHYDROGENASE IP
SUBUNIT

(Gallus gallus) 		PF13085
(Fer2_3)
PF13534
(Fer4_17) 		5 ALA B 162
ALA B 182
LEU B 229
LEU B 160
SER B  72
 None
SF4  B1003 ( 3.7A)
SF4  B1003 ( 4.7A)
None
FES  B1002 ( 4.6A)
 1.13A 4or0B-1yq3B:
undetectable		 4or0B-1yq3B:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adc POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1)
PF13893
(RRM_5) 		5 ALA A 377
LEU A 339
LEU A 344
SER A 353
VAL A 349
 None
 1.15A 4or0B-2adcA:
undetectable		 4or0B-2adcA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1m L-GLUTAMATE OXIDASE

(Streptomyces
sp. X-119-6) 		PF01593
(Amino_oxidase) 		5 ALA C 561
ALA C 583
LEU B 440
LEU C 559
VAL C 558
 None
 1.10A 4or0B-2e1mC:
undetectable		 4or0B-2e1mC:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 156
LEU A 158
LEU A 328
SER A 148
VAL A 333
 None
 1.17A 4or0B-2hw6A:
undetectable		 4or0B-2hw6A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7d RIBONUCLEASE II
FAMILY PROTEIN

(Deinococcus
radiodurans) 		PF00773
(RNB) 		5 ALA A  39
ALA A  42
SER A  25
LEU A  17
VAL A  14
 None
 1.09A 4or0B-2r7dA:
undetectable		 4or0B-2r7dA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16739
(CARD_2) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.13A 4or0B-2vgqA:
undetectable		 4or0B-2vgqA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine leukemia
virus;
Escherichia
coli) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		5 ALA A 290
ALA A 131
LEU A 129
LEU A 288
VAL A 287
 None
 1.16A 4or0B-2xz3A:
undetectable		 4or0B-2xz3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeb SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL

(Sus scrofa) 		PF13085
(Fer2_3)
PF13534
(Fer4_17) 		5 ALA B 162
ALA B 182
LEU B 229
LEU B 160
SER B  72
 None
SF4  B 303 (-3.6A)
SF4  B 303 ( 4.5A)
None
None
 1.11A 4or0B-3aebB:
undetectable		 4or0B-3aebB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		5 ALA A 578
ALA A 607
LEU A 605
LEU A 575
SER A 519
 None
 1.12A 4or0B-3azqA:
undetectable		 4or0B-3azqA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Arabidopsis
thaliana;
Escherichia
coli) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.13A 4or0B-3dm0A:
undetectable		 4or0B-3dm0A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 ALA A -85
ALA A-244
LEU A-246
LEU A -87
VAL A -88
 None
 1.17A 4or0B-3ehsA:
undetectable		 4or0B-3ehsA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.15A 4or0B-3f5fA:
undetectable		 4or0B-3f5fA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhl PUTATIVE
OXIDOREDUCTASE

(Bacteroides
fragilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ALA A  80
ALA A  83
LEU A  58
SER A 118
LEU A 117
 None
 1.10A 4or0B-3fhlA:
undetectable		 4or0B-3fhlA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqp HEMOGLOBIN SUBUNIT
ALPHA

(Felis catus) 		PF00042
(Globin) 		5 ALA A  69
LEU A  76
SER A  84
LEU A 136
VAL A 135
 None
None
None
HEM  A 143 (-4.9A)
None
 1.12A 4or0B-3gqpA:
2.3		 4or0B-3gqpA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 ALA C 410
ALA C 413
SER C 402
LEU C 401
VAL C 399
 None
 1.06A 4or0B-3gzdC:
undetectable		 4or0B-3gzdC:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4z MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH ALLERGEN
DERP7

(Dermatophagoides
pteronyssinus;
Escherichia
coli) 		PF13416
(SBP_bac_8)
PF16984
(Grp7_allergen) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.12A 4or0B-3h4zA:
undetectable		 4or0B-3h4zA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp6 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,LINKER,SAGA-
ASSOCIATED FACTOR 29

(Escherichia
coli;
Saccharomyces
cerevisiae;
unidentified) 		PF07039
(DUF1325)
PF13416
(SBP_bac_8) 		5 ALA A1002
ALA A 843
LEU A 841
LEU A1000
VAL A 999
 None
 1.13A 4or0B-3mp6A:
undetectable		 4or0B-3mp6A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n93 MALTOSE BINDING
PROTEIN-CRFR2 ALPHA

(Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 ALA A-106
ALA A-265
LEU A-267
LEU A-108
VAL A-109
 None
 1.16A 4or0B-3n93A:
undetectable		 4or0B-3n93A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 ALA A -84
ALA A-243
LEU A-245
LEU A -86
VAL A -87
 None
 1.14A 4or0B-3n94A:
undetectable		 4or0B-3n94A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nh9 ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
6, MITOCHONDRIAL

(Homo sapiens) 		PF00005
(ABC_tran) 		5 ALA A 620
ALA A 782
LEU A 785
LEU A 795
VAL A 796
 None
 1.12A 4or0B-3nh9A:
undetectable		 4or0B-3nh9A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF08205
(C2-set_2)
PF13416
(SBP_bac_8) 		5 ALA N 264
ALA N 105
LEU N 103
LEU N 262
VAL N 261
 None
 1.14A 4or0B-3o3uN:
undetectable		 4or0B-3o3uN:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0

(Escherichia
coli;
Homo sapiens) 		PF07686
(V-set)
PF13416
(SBP_bac_8) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.13A 4or0B-3oaiA:
undetectable		 4or0B-3oaiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob4 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ARAH 2

(Arachis
duranensis;
Escherichia
coli) 		PF00234
(Tryp_alpha_amyl)
PF13416
(SBP_bac_8) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.08A 4or0B-3ob4A:
undetectable		 4or0B-3ob4A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		5 ALA A 512
ALA A 105
LEU A 103
LEU A 510
VAL A 509
 None
 1.14A 4or0B-3osqA:
undetectable		 4or0B-3osqA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vd8 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
INTERFERON-INDUCIBLE
PROTEIN AIM2

(Escherichia
coli;
Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.14A 4or0B-3vd8A:
undetectable		 4or0B-3vd8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus;
Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.16A 4or0B-3waiA:
undetectable		 4or0B-3waiA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5

(Escherichia
coli;
Macaca mulatta) 		PF00622
(SPRY)
PF01547
(SBP_bac_1) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.16A 4or0B-4b3nA:
2.3		 4or0B-4b3nA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN

(Escherichia
coli;
Mus musculus) 		PF07679
(I-set)
PF13416
(SBP_bac_8) 		5 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
 None
 1.17A 4or0B-4edqA:
undetectable		 4or0B-4edqA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		PF00046
(Homeobox)
PF13416
(SBP_bac_8)
PF16878
(SIX1_SD) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.14A 4or0B-4egcA:
undetectable		 4or0B-4egcA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica) 		PF13416
(SBP_bac_8)
PF16583
(ZirS_C) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.16A 4or0B-4exkA:
undetectable		 4or0B-4exkA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3y DIHYDRODIPICOLINATE
REDUCTASE

(Burkholderia
thailandensis) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		5 ALA A  47
ALA A  11
LEU A  35
LEU A  24
VAL A  23
 None
 1.12A 4or0B-4f3yA:
undetectable		 4or0B-4f3yA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01547
(SBP_bac_1) 		5 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
 None
 1.16A 4or0B-4gizA:
undetectable		 4or0B-4gizA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Candida
albicans;
Escherichia
coli) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 ALA A-106
ALA A-265
LEU A-267
LEU A-108
VAL A-109
 None
 1.11A 4or0B-4h1gA:
undetectable		 4or0B-4h1gA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NACHT, LRR
AND PYD
DOMAINS-CONTAINING
PROTEIN 1

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
 None
 1.16A 4or0B-4ifpA:
undetectable		 4or0B-4ifpA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY

(Danio rerio;
Escherichia
coli) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
 None
 1.15A 4or0B-4irlA:
undetectable		 4or0B-4irlA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7m PROTEIN DOM3Z

(Mus musculus) 		PF08652
(RAI1) 		5 LEU A 124
LEU A  49
SER A 232
LEU A 220
VAL A 219
 None
 1.12A 4or0B-4j7mA:
undetectable		 4or0B-4j7mA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.16A 4or0B-4kegA:
undetectable		 4or0B-4kegA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF08817
(YukD)
PF13416
(SBP_bac_8) 		5 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
 None
 1.16A 4or0B-4kv3A:
undetectable		 4or0B-4kv3A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lji CYTOCHROME
C-550-LIKE PROTEIN

(Thermosynechococcus
elongatus) 		PF14495
(Cytochrom_C550) 		5 ALA A 124
LEU A 117
LEU A  36
LYS A  40
VAL A   8
 None
HEM  A 301 ( 4.6A)
None
None
None
 1.04A 4or0B-4ljiA:
undetectable		 4or0B-4ljiA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 ALA B 120
ALA B 116
LEU B 114
LEU B  61
VAL B 130
 None
 1.11A 4or0B-4mrmB:
undetectable		 4or0B-4mrmB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuf MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
NUCLEAR RECEPTOR
SUBFAMILY 0 GROUP B
MEMBER 2 CHIMERIC
CONSTRUCT

(Escherichia
coli;
Mus musculus) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		5 ALA A 266
ALA A 107
LEU A 105
LEU A 264
VAL A 263
 None
 1.15A 4or0B-4nufA:
undetectable		 4or0B-4nufA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2x MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ATP-DEPENDENT CLP
PROTEASE ADAPTOR
PROTEIN CLPS
CONTAINING PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Plasmodium
falciparum) 		PF02617
(ClpS)
PF13416
(SBP_bac_8) 		5 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
 None
 1.16A 4or0B-4o2xA:
undetectable		 4or0B-4o2xA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe2 MALTOSE ABC
TRANSPORTER
PERIPLASMIC
PROTEIN,PREPILIN-TYP
E N-TERMINAL
CLEAVAGE/METHYLATION
DOMAIN PROTEIN

(Clostridioides
difficile;
Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.16A 4or0B-4pe2A:
undetectable		 4or0B-4pe2A:
24.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		7 ALA A 210
ALA A 213
LEU A 347
LYS A 351
SER A 480
LEU A 481
VAL A 482
 None
NPS  A 602 (-3.3A)
NPS  A 602 ( 4.2A)
None
None
None
None
 0.84A 4or0B-4po0A:
49.7		 4or0B-4po0A:
71.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		7 ALA A 213
LEU A 327
LEU A 347
LYS A 351
SER A 480
LEU A 481
VAL A 482
 NPS  A 602 (-3.3A)
NPS  A 602 ( 4.7A)
NPS  A 602 ( 4.2A)
None
None
None
None
 0.78A 4or0B-4po0A:
49.7		 4or0B-4po0A:
71.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		7 ARG A 209
ALA A 210
ALA A 213
LEU A 347
SER A 480
LEU A 481
VAL A 482
 NPS  A 602 (-3.6A)
None
NPS  A 602 (-3.3A)
NPS  A 602 ( 4.2A)
None
None
None
 0.86A 4or0B-4po0A:
49.7		 4or0B-4po0A:
71.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		7 ARG A 209
ALA A 213
LEU A 327
LEU A 347
SER A 480
LEU A 481
VAL A 482
 NPS  A 602 (-3.6A)
NPS  A 602 (-3.3A)
NPS  A 602 ( 4.7A)
NPS  A 602 ( 4.2A)
None
None
None
 0.95A 4or0B-4po0A:
49.7		 4or0B-4po0A:
71.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqk MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
TRUNCATED
REPLICATION PROTEIN
REPA

(Escherichia
coli;
Staphylococcus
aureus) 		PF13416
(SBP_bac_8) 		5 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
 None
 1.10A 4or0B-4pqkA:
undetectable		 4or0B-4pqkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA

(Escherichia
coli;
Mus musculus) 		PF13416
(SBP_bac_8)
PF13621
(Cupin_8) 		5 ALA A-107
ALA A-266
LEU A-268
LEU A-109
VAL A-110
 None
 1.16A 4or0B-4qszA:
undetectable		 4or0B-4qszA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		5 ALA A 266
ALA A 107
LEU A 105
LEU A 264
VAL A 263
 None
 1.13A 4or0B-4rwfA:
undetectable		 4or0B-4rwfA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA

(Clostridioides
difficile;
Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.13A 4or0B-4tsmA:
undetectable		 4or0B-4tsmA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uis GAMMA-SECRETASE

(Homo sapiens) 		PF05450
(Nicastrin) 		5 ALA A 369
LEU A 365
LEU A 487
LEU A 522
VAL A 518
 None
 1.17A 4or0B-4uisA:
undetectable		 4or0B-4uisA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB

(Escherichia
coli;
Staphylococcus
aureus) 		PF00717
(Peptidase_S24)
PF13416
(SBP_bac_8) 		5 ALA A 270
ALA A 111
LEU A 109
LEU A 268
VAL A 267
 None
 1.14A 4or0B-4wviA:
undetectable		 4or0B-4wviA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C

(Acinetobacter
baumannii;
Escherichia
coli) 		PF00114
(Pilin)
PF13416
(SBP_bac_8) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.17A 4or0B-4xa2A:
undetectable		 4or0B-4xa2A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaj MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR
RECEPTOR SUBFAMILY 2
GROUP E MEMBER 1

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		5 ALA A 266
ALA A 107
LEU A 105
LEU A 264
VAL A 263
 None
 1.13A 4or0B-4xajA:
3.0		 4or0B-4xajA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yue S4B6 FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA H  75
ALA H  82
LEU H  84
LEU H  37
SER H  60
 None
 1.08A 4or0B-4yueH:
undetectable		 4or0B-4yueH:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.14A 4or0B-5azaA:
2.4		 4or0B-5azaA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12

(Escherichia
coli;
Zoarces
americanus) 		PF01547
(SBP_bac_1) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.13A 4or0B-5c7rA:
undetectable		 4or0B-5c7rA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MALTOSE-BIND
ING PERIPLASMIC
PROTEIN,PILA FUSION
PROTEIN

(Acinetobacter
nosocomialis;
Escherichia
coli) 		PF00114
(Pilin)
PF01547
(SBP_bac_1) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.16A 4or0B-5cfvA:
undetectable		 4or0B-5cfvA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19

(Escherichia
coli;
Tetrahymena
thermophila) 		PF13416
(SBP_bac_8) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.17A 4or0B-5dfmA:
undetectable		 4or0B-5dfmA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		5 ALA D 264
ALA D 105
LEU D 103
LEU D 262
VAL D 261
 None
 1.15A 4or0B-5disD:
undetectable		 4or0B-5disD:
23.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 ALA A 209
ALA A 212
LEU A 346
SER A 479
LEU A 480
 CZE  A 613 ( 4.4A)
CZE  A 613 ( 3.7A)
CZE  A 613 ( 3.8A)
None
None
 0.85A 4or0B-5dqfA:
50.2		 4or0B-5dqfA:
73.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 ALA A 209
LEU A 346
LYS A 350
SER A 479
LEU A 480
 CZE  A 613 ( 4.4A)
CZE  A 613 ( 3.8A)
CZE  A 613 (-4.1A)
None
None
 1.08A 4or0B-5dqfA:
50.2		 4or0B-5dqfA:
73.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 ALA A 212
LEU A 326
LEU A 346
SER A 479
LEU A 480
 CZE  A 613 ( 3.7A)
CZE  A 613 ( 4.7A)
CZE  A 613 ( 3.8A)
None
None
 0.97A 4or0B-5dqfA:
50.2		 4or0B-5dqfA:
73.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 ARG A 208
ALA A 209
ALA A 212
LEU A 346
LEU A 480
 CZE  A 613 ( 3.5A)
CZE  A 613 ( 4.4A)
CZE  A 613 ( 3.7A)
CZE  A 613 ( 3.8A)
None
 0.92A 4or0B-5dqfA:
50.2		 4or0B-5dqfA:
73.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 LEU A 326
LEU A 346
LYS A 350
SER A 479
LEU A 480
 CZE  A 613 ( 4.7A)
CZE  A 613 ( 3.8A)
CZE  A 613 (-4.1A)
None
None
 1.02A 4or0B-5dqfA:
50.2		 4or0B-5dqfA:
73.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 ALA B 372
ALA B 213
LEU B 211
LEU B 370
VAL B 369
 None
 1.14A 4or0B-5eduB:
undetectable		 4or0B-5eduB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exk LIPOYL SYNTHASE

(Mycobacterium
tuberculosis) 		PF04055
(Radical_SAM)
PF16881
(LIAS_N) 		6 ALA A 210
ALA A 206
LEU A 204
LEU A 166
SER A 172
VAL A 169
 None
 1.25A 4or0B-5exkA:
undetectable		 4or0B-5exkA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		5 ALA A2137
LEU A1988
SER A2184
LEU A2185
VAL A2186
 None
 0.93A 4or0B-5fbyA:
undetectable		 4or0B-5fbyA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsg MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HANTAVIRUS
NUCLEOPROTEIN

(Hantaan
orthohantavirus) 		PF00846
(Hanta_nucleocap)
PF13416
(SBP_bac_8) 		5 ALA A-108
ALA A-267
LEU A-269
LEU A-110
VAL A-111
 None
 1.12A 4or0B-5fsgA:
undetectable		 4or0B-5fsgA:
22.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		7 ALA A 210
ALA A 213
LEU A 327
LEU A 347
LYS A 351
LEU A 481
VAL A 482
 None
 1.03A 4or0B-5ghkA:
46.3		 4or0B-5ghkA:
76.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		5 LEU A 327
LYS A 351
SER A 480
LEU A 481
VAL A 482
 None
 1.11A 4or0B-5ghkA:
46.3		 4or0B-5ghkA:
76.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
 None
 1.16A 4or0B-5h7nA:
undetectable		 4or0B-5h7nA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz7 COMP

(Neisseria
meningitidis) 		PF13416
(SBP_bac_8)
PF16732
(ComP_DUS) 		5 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
 None
None
NA  A 506 (-3.9A)
None
None
 1.16A 4or0B-5hz7A:
undetectable		 4or0B-5hz7A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		5 ALA A 631
ALA A 472
LEU A 470
LEU A 629
VAL A 628
 None
 1.16A 4or0B-5hzvA:
undetectable		 4or0B-5hzvA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		5 ALA A 319
ALA A 160
LEU A 158
LEU A 317
VAL A 316
 None
 1.14A 4or0B-5hzwA:
undetectable		 4or0B-5hzwA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		5 ALA A3931
ALA A3772
LEU A3770
LEU A3929
VAL A3928
 None
 1.17A 4or0B-5ii5A:
undetectable		 4or0B-5ii5A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE

(Escherichia
coli;
Homo sapiens) 		no annotation 5 ALA C 264
ALA C 105
LEU C 103
LEU C 262
VAL C 261
 None
 1.17A 4or0B-5jj4C:
undetectable		 4or0B-5jj4C:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2

(Escherichia
coli;
Mus musculus) 		PF00027
(cNMP_binding)
PF13416
(SBP_bac_8) 		5 ALA A-105
ALA A-264
LEU A-266
LEU A-107
VAL A-108
 None
 1.14A 4or0B-5jonA:
undetectable		 4or0B-5jonA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 ALA A 390
ALA A 553
LEU A 556
LEU A 566
VAL A 567
 None
 1.17A 4or0B-5mkkA:
undetectable		 4or0B-5mkkA:
22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 7 ARG A 208
ALA A 209
ALA A 212
LEU A 326
LEU A 346
LEU A 480
VAL A 481
 None
 0.65A 4or0B-5oriA:
51.8		 4or0B-5oriA:
91.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 7 ARG A 208
ALA A 209
LEU A 326
LEU A 346
SER A 479
LEU A 480
VAL A 481
 None
 0.82A 4or0B-5oriA:
51.8		 4or0B-5oriA:
91.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3

(Escherichia
coli;
Mus musculus) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		5 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
 None
 1.14A 4or0B-5osqA:
undetectable		 4or0B-5osqA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio rerio;
Escherichia
coli) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.12A 4or0B-5t03A:
undetectable		 4or0B-5t03A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF04598
(Gasdermin)
PF13416
(SBP_bac_8) 		5 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.17A 4or0B-5tj2A:
undetectable		 4or0B-5tj2A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN

(Escherichia
coli;
Streptococcus
pyogenes) 		PF12892
(FctA)
PF13416
(SBP_bac_8) 		5 ALA A 270
ALA A 111
LEU A 109
LEU A 268
VAL A 267
 None
 1.16A 4or0B-5ttdA:
undetectable		 4or0B-5ttdA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR

(Escherichia
coli;
Homo sapiens) 		no annotation 5 ALA A 266
ALA A 107
LEU A 105
LEU A 264
VAL A 263
 None
 1.10A 4or0B-5v6yA:
undetectable		 4or0B-5v6yA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq6 MBP TAGGED HMNDA-PYD

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
 None
 1.17A 4or0B-5wq6A:
undetectable		 4or0B-5wq6A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxp LYSR-TYPE REGULATORY
PROTEIN

(Cupriavidus
necator) 		no annotation 5 ALA A  21
ALA A  11
LEU A  25
SER A  28
VAL A  27
 None
 1.17A 4or0B-5xxpA:
undetectable		 4or0B-5xxpA:
11.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 7 ARG A 209
ALA A 210
ALA A 213
LEU A 327
LEU A 347
LEU A 481
VAL A 482
 None
 0.82A 4or0B-5yxeA:
44.4		 4or0B-5yxeA:
78.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN

(Escherichia
coli) 		no annotation 5 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
 None
 1.17A 4or0B-5z0rA:
undetectable		 4or0B-5z0rA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage JBD30) 		no annotation 5 ALA A 344
ALA A 185
LEU A 183
LEU A 342
VAL A 341
 None
 1.17A 4or0B-6anvA:
undetectable		 4or0B-6anvA:
22.59