SIMILAR PATTERNS OF AMINO ACIDS FOR 4OR0_B_NPSB601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE

(Paracoccus
denitrificans) 		PF13473
(Cupredoxin_1) 		5 ASN A 273
CYH A 282
ARG A 131
THR A 336
LEU A 377
 CL  A4901 (-3.5A)
None
CL  A4901 (-3.1A)
None
None
 1.42A 4or0B-1fwxA:
undetectable		 4or0B-1fwxA:
22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		8 ASN A 391
PHE A 403
ARG A 410
TYR A 411
LYS A 414
VAL A 433
LEU A 453
SER A 489
 None
 0.73A 4or0B-1tf0A:
44.7		 4or0B-1tf0A:
76.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkl PROLYL ENDOPEPTIDASE

(Myxococcus
xanthus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 ARG A 465
TYR A 478
VAL A 554
LEU A 667
SER A 467
 None
 1.50A 4or0B-2bklA:
0.0		 4or0B-2bklA:
22.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		8 ASN A 391
PHE A 403
ARG A 410
TYR A 411
LYS A 414
VAL A 433
LEU A 453
SER A 489
 NPS  A 601 (-4.3A)
None
NPS  A 601 (-4.5A)
NPS  A 601 (-4.3A)
NPS  A 601 (-2.7A)
None
NPS  A 601 (-4.7A)
NPS  A 601 (-3.1A)
 0.47A 4or0B-4po0A:
49.7		 4or0B-4po0A:
71.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		7 ASN A 390
PHE A 402
ARG A 409
LYS A 413
VAL A 432
LEU A 452
SER A 488
 None
 0.79A 4or0B-5dqfA:
50.2		 4or0B-5dqfA:
73.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		7 ASN A 390
PHE A 402
ARG A 409
TYR A 410
LYS A 413
VAL A 432
SER A 488
 None
 0.63A 4or0B-5dqfA:
50.2		 4or0B-5dqfA:
73.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		8 ASN A 391
PHE A 403
ARG A 410
TYR A 411
LYS A 414
VAL A 433
LEU A 453
SER A 489
 None
 0.60A 4or0B-5ghkA:
46.3		 4or0B-5ghkA:
76.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 9 ASN A 390
PHE A 402
ARG A 409
TYR A 410
LYS A 413
VAL A 432
THR A 448
LEU A 452
SER A 488
 None
 0.72A 4or0B-5oriA:
51.8		 4or0B-5oriA:
91.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 7 ASN A 391
PHE A 403
ARG A 410
TYR A 411
LYS A 414
VAL A 433
LEU A 453
 None
 0.74A 4or0B-5yxeA:
44.4		 4or0B-5yxeA:
78.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 7 ASN A 391
PHE A 403
TYR A 411
LYS A 414
VAL A 433
LEU A 453
SER A 489
 None
 0.68A 4or0B-5yxeA:
44.4		 4or0B-5yxeA:
78.75