SIMILAR PATTERNS OF AMINO ACIDS FOR 4OR0_A_NPSA603

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqn DNA PRIMASE

(Escherichia
coli) 		PF08275
(Toprim_N)
PF10410
(DnaB_bind)
PF13155
(Toprim_2) 		5 ARG A 146
LEU A 143
ARG A 221
LEU A 148
LEU A 131
 None
 1.39A 4or0A-1eqnA:
2.1		 4or0A-1eqnA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		5 SER A  15
LEU A  10
ASP A 453
LEU A 457
LEU A  11
 None
 1.43A 4or0A-1fp9A:
0.0		 4or0A-1fp9A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4v HISTIDYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 ARG B 398
LEU B 416
LEU B 333
LEU B 420
LEU B 351
 None
 1.35A 4or0A-1h4vB:
0.5		 4or0A-1h4vB:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kvk MEVALONATE KINASE

(Rattus
norvegicus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 157
ARG A 121
LEU A 126
LEU A 115
LEU A 129
 None
 1.35A 4or0A-1kvkA:
2.1		 4or0A-1kvkA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 LEU A 242
ARG A 243
LEU A 274
LEU A 453
LEU A 304
 None
 1.27A 4or0A-1loxA:
0.0		 4or0A-1loxA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc0 3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 2A

(Mus musculus) 		PF01590
(GAF)
PF13185
(GAF_2) 		5 LEU A 289
ARG A 288
LEU A 301
LEU A 339
LEU A 312
 None
 1.39A 4or0A-1mc0A:
0.0		 4or0A-1mc0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1peg HISTONE H3
METHYLTRANSFERASE
DIM-5

(Neurospora
crassa) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 ARG A 177
LEU A  26
ASP A  47
LEU A 179
LEU A 151
 None
 1.41A 4or0A-1pegA:
undetectable		 4or0A-1pegA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ARG A 683
LEU A 682
ARG A 686
LEU A 679
LEU A 769
 None
 1.45A 4or0A-1t46A:
0.6		 4or0A-1t46A:
20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 LEU A 198
SER A 202
LEU A 347
ASP A 451
LEU A 481
 None
None
DKA  A1002 ( 4.3A)
CIT  A2001 ( 4.6A)
None
 0.82A 4or0A-1tf0A:
45.0		 4or0A-1tf0A:
76.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 LEU A 198
SER A 202
TRP A 214
LEU A 347
ASP A 451
 None
None
None
DKA  A1002 ( 4.3A)
CIT  A2001 ( 4.6A)
 0.93A 4or0A-1tf0A:
45.0		 4or0A-1tf0A:
76.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		5 SER A  12
LEU A   7
ASP A 439
LEU A 443
LEU A   8
 None
 1.43A 4or0A-1tz7A:
0.3		 4or0A-1tz7A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0d DNA FRAGMENTATION
FACTOR 40 KDA
SUBUNIT

(Mus musculus) 		PF09230
(DFF40) 		5 ARG A 168
LEU A 171
ARG A 172
SER A 175
LEU A 193
 None
 1.08A 4or0A-1v0dA:
undetectable		 4or0A-1v0dA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhz ADP COMPOUNDS
HYDROLASE NUDE

(Escherichia
coli) 		PF00293
(NUDIX) 		5 LEU A 173
ARG A 177
ASP A 157
LEU A 159
LEU A  60
 None
 1.25A 4or0A-1vhzA:
undetectable		 4or0A-1vhzA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		5 SER A  36
LEU A  31
ASP A 474
LEU A 478
LEU A  32
 None
 1.39A 4or0A-1x1nA:
2.2		 4or0A-1x1nA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au5 CONSERVED DOMAIN
PROTEIN

(Enterococcus
faecalis) 		PF11472
(DUF3206) 		5 ARG A  88
ARG A  91
LEU A  26
LEU A 108
LEU A  96
 None
 1.46A 4or0A-2au5A:
2.3		 4or0A-2au5A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 ARG A 330
LEU A 331
SER A 360
LEU A 361
LEU A 334
 None
 1.39A 4or0A-2b9eA:
undetectable		 4or0A-2b9eA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f31 DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		5 LEU A 156
ARG A 210
LEU A 186
LEU A 153
LEU A 182
 None
 1.30A 4or0A-2f31A:
2.4		 4or0A-2f31A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0a TRANSCRIPTIONAL
REGULATOR

(Thermus
thermophilus) 		PF13377
(Peripla_BP_3) 		5 LEU A 260
ARG A 331
LEU A 277
ASP A 253
LEU A 257
 None
 1.32A 4or0A-2h0aA:
undetectable		 4or0A-2h0aA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8o GERANYLTRANSTRANSFER
ASE

(Agrobacterium
fabrum) 		PF00348
(polyprenyl_synt) 		5 ARG A  89
LEU A  92
SER A  96
LEU A  88
LEU A 323
 None
 1.26A 4or0A-2h8oA:
3.1		 4or0A-2h8oA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jhe TRANSCRIPTION
REGULATOR TYRR

(Escherichia
coli) 		PF13188
(PAS_8) 		5 LEU A  94
SER A 109
LEU A 117
ASP A 103
LEU A 120
 None
 1.46A 4or0A-2jheA:
undetectable		 4or0A-2jheA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mvu ACTINORHODIN
POLYKETIDE SYNTHASE
ACYL CARRIER PROTEIN

(Streptomyces
coelicolor) 		PF00550
(PP-binding) 		5 ARG A  72
LEU A  75
LEU A   4
LEU A  31
LEU A   5
 None
 1.25A 4or0A-2mvuA:
undetectable		 4or0A-2mvuA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nox TRYPTOPHAN
2,3-DIOXYGENASE

(Cupriavidus
metallidurans) 		PF03301
(Trp_dioxygenase) 		5 LEU A  86
ARG A  90
LEU A 288
LEU A  83
LEU A 246
 None
 1.23A 4or0A-2noxA:
undetectable		 4or0A-2noxA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojq PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF13949
(ALIX_LYPXL_bnd) 		5 ARG A 496
LEU A 499
ASP A 452
LEU A 451
LEU A 444
 None
 1.31A 4or0A-2ojqA:
undetectable		 4or0A-2ojqA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN

(Homo sapiens) 		PF02545
(Maf) 		5 ARG A 113
LEU A 114
ARG A 117
LEU A 160
LEU A  98
 None
 1.43A 4or0A-2p5xA:
2.5		 4or0A-2p5xA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 LEU A 100
ARG A 101
ASP A 194
LEU A 195
LEU A 202
 None
 1.39A 4or0A-2pjrA:
undetectable		 4or0A-2pjrA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		5 LEU A 483
ARG A 487
LEU A 506
LEU A 480
LEU A 468
 None
 1.42A 4or0A-2pziA:
2.4		 4or0A-2pziA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 LEU A 110
SER A 190
LEU A 189
LEU A 231
LEU A 238
 None
 1.15A 4or0A-2qn0A:
undetectable		 4or0A-2qn0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd9 ALANINE RACEMASE

(Bacillus
anthracis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 LEU A  69
SER A  90
LEU A  85
LEU A  73
LEU A 105
 None
 1.44A 4or0A-2vd9A:
undetectable		 4or0A-2vd9A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		5 LEU A1401
SER A1399
LEU A1220
LEU A1345
LEU A1221
 None
 1.45A 4or0A-2vz9A:
undetectable		 4or0A-2vz9A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1i 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
brockianus) 		PF02446
(Glyco_hydro_77) 		5 SER A  15
LEU A  10
ASP A 453
LEU A 457
LEU A  11
 None
 1.41A 4or0A-2x1iA:
undetectable		 4or0A-2x1iA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI

(Pseudomonas
putida) 		PF10778
(DehI) 		5 LEU A  72
ARG A  73
SER A  76
LEU A 119
LEU A 224
 None
 1.31A 4or0A-3bjxA:
1.7		 4or0A-3bjxA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clj PROTEIN NRD1

(Saccharomyces
cerevisiae) 		PF04818
(CTD_bind) 		5 LEU A  66
SER A  54
LEU A 101
LEU A 127
LEU A 108
 None
 1.32A 4or0A-3cljA:
undetectable		 4or0A-3cljA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		5 LEU A 241
ARG A 242
LEU A 273
LEU A 452
LEU A 303
 None
 1.30A 4or0A-3d3lA:
1.8		 4or0A-3d3lA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 LEU A 346
SER A 326
LEU A 203
ASP A 178
LEU A 202
 None
 1.34A 4or0A-3ddrA:
undetectable		 4or0A-3ddrA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6w XRE-FAMILY LIKE
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF13560
(HTH_31) 		5 LEU A  74
ARG A   8
LEU A  13
LEU A  71
LEU A  15
 None
 1.39A 4or0A-3f6wA:
undetectable		 4or0A-3f6wA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hv9 PROTEIN FIMX

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		5 ARG A 457
LEU A 480
LEU A 451
LEU A 481
LEU A 447
 GOL  A 906 ( 4.5A)
None
None
None
None
 1.03A 4or0A-3hv9A:
undetectable		 4or0A-3hv9A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg3 ISOCITRATE LYASE

(Yersinia pestis) 		PF00463
(ICL) 		5 ARG A   5
SER A  29
ASP A  32
LEU A  36
LEU A  12
 None
 1.48A 4or0A-3lg3A:
undetectable		 4or0A-3lg3A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE

(Streptococcus
agalactiae) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A 420
ARG A 437
SER A 331
LEU A 351
LEU A 314
 None
 1.47A 4or0A-3lk7A:
undetectable		 4or0A-3lk7A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpz GET4 (YOR164C
HOMOLOG)

(Chaetomium
thermophilum) 		PF04190
(DUF410) 		5 LEU A  70
ARG A  32
SER A  66
LEU A  51
LEU A  58
 None
 1.42A 4or0A-3lpzA:
3.3		 4or0A-3lpzA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		5 ARG A  45
LEU A  48
SER A  52
LEU A  44
LEU A 277
 None
 1.31A 4or0A-3m0gA:
2.0		 4or0A-3m0gA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 LEU A 770
SER A 749
ASP A 211
LEU A 210
LEU A 203
 None
 1.43A 4or0A-3ne5A:
undetectable		 4or0A-3ne5A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om8 PROBABLE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 LEU A  77
ARG A  60
SER A 189
SER A  31
LEU A 100
 None
None
None
None
EDO  A 266 (-3.7A)
 1.21A 4or0A-3om8A:
undetectable		 4or0A-3om8A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT

(Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N) 		5 ARG A 301
LEU A 305
LEU A 231
LEU A 267
LEU A 239
 AMP  A 992 (-3.7A)
None
None
None
None
 1.34A 4or0A-3pcoA:
undetectable		 4or0A-3pcoA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		5 LEU B 229
SER B 242
SER B 226
ASP B   7
LEU B 263
 None
 1.35A 4or0A-3pz2B:
undetectable		 4or0A-3pz2B:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3siu U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP31

(Homo sapiens) 		PF01798
(Nop) 		5 ARG B 121
LEU B 142
ASP B 147
LEU B 146
LEU B 155
 None
 1.42A 4or0A-3siuB:
4.4		 4or0A-3siuB:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CRISPR SYSTEM CMR
SUBUNIT CMR5

(Archaeoglobus
fulgidus) 		PF09701
(Cas_Cmr5) 		5 LEU F  98
ARG F  10
LEU F 137
LEU F 111
LEU F  51
 None
 1.31A 4or0A-3x1lF:
undetectable		 4or0A-3x1lF:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0l CULLIN-4B

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		5 ARG E 779
LEU E 782
ASP E 806
LEU E 764
LEU E 793
 None
 1.28A 4or0A-4a0lE:
undetectable		 4or0A-4a0lE:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		5 ARG A 101
LEU A 102
LEU A 192
ASP A 489
LEU A 113
 None
 1.44A 4or0A-4a5qA:
undetectable		 4or0A-4a5qA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0e NOT1

(Chaetomium
thermophilum) 		PF04054
(Not1) 		5 ARG A1849
LEU A1853
TRP A1860
ASP A1847
LEU A1852
 None
 1.33A 4or0A-4c0eA:
undetectable		 4or0A-4c0eA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2t DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 LEU A 100
ARG A 101
ASP A 198
LEU A 199
LEU A 206
 None
 1.36A 4or0A-4c2tA:
undetectable		 4or0A-4c2tA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etz PELD

(Pseudomonas
aeruginosa) 		PF13492
(GAF_3)
PF16963
(PelD_GGDEF) 		5 ARG A 404
LEU A 403
SER A 365
LEU A 384
LEU A 400
 None
 1.48A 4or0A-4etzA:
undetectable		 4or0A-4etzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH) 		5 ARG A 441
LEU A 440
SER A 350
SER A 449
LEU A  32
 None
 1.22A 4or0A-4ix2A:
undetectable		 4or0A-4ix2A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw7 ARSENIC
METHYLTRANSFERASE

(Cyanidioschyzon
sp. 5508) 		PF13847
(Methyltransf_31) 		5 LEU A 100
SER A  53
ASP A  79
LEU A  76
LEU A  58
 None
 1.28A 4or0A-4kw7A:
undetectable		 4or0A-4kw7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 398
SER A 369
LEU A 372
LEU A 435
LEU A 442
 None
 1.21A 4or0A-4n5cA:
undetectable		 4or0A-4n5cA:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		6 LEU A 198
ARG A 199
SER A 202
LEU A 347
ASP A 451
LEU A 481
 None
None
None
NPS  A 602 ( 4.2A)
None
None
 0.87A 4or0A-4po0A:
50.1		 4or0A-4po0A:
71.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po6 INTERFERON
ALPHA/BETA RECEPTOR
1
NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		no annotation 5 LEU A  73
SER A 148
LEU B 492
LEU A 426
LEU A 144
 None
 1.16A 4or0A-4po6A:
undetectable		 4or0A-4po6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rd9 AMYLOID-LIKE PROTEIN
1

(Homo sapiens) 		PF12925
(APP_E2) 		5 ARG A 414
LEU A 413
SER A 463
LEU A 410
LEU A 464
 None
 1.39A 4or0A-4rd9A:
2.6		 4or0A-4rd9A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsd HP1029

(Helicobacter
pylori) 		no annotation 5 LEU B  27
SER B  60
LEU B  54
LEU B  89
LEU B  23
 None
 1.44A 4or0A-4tsdB:
undetectable		 4or0A-4tsdB:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ARG A  23
SER A  25
SER A 218
ASP A 216
LEU A 225
 None
 1.48A 4or0A-4udrA:
undetectable		 4or0A-4udrA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 ARG A 483
SER A 487
ARG A 482
LEU A 535
LEU A 462
 None
 1.21A 4or0A-4xhjA:
undetectable		 4or0A-4xhjA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynv ACL4

(Chaetomium
thermophilum) 		PF13432
(TPR_16) 		5 ARG A 231
LEU A 234
ARG A 235
SER A 237
LEU A 260
 None
 1.32A 4or0A-4ynvA:
2.2		 4or0A-4ynvA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 LEU A 820
SER A1241
ARG A 793
SER A1162
LEU A 576
 None
 1.49A 4or0A-5a22A:
undetectable		 4or0A-5a22A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bup ZONA PELLUCIDA
SPERM-BINDING
PROTEIN 2

(Mus musculus) 		PF00100
(Zona_pellucida) 		5 LEU A 622
SER A 620
SER A 609
ASP A 537
LEU A 611
 None
None
ACT  A 701 (-3.3A)
ACT  A 703 ( 3.3A)
None
 1.46A 4or0A-5bupA:
undetectable		 4or0A-5bupA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF12897
(Aminotran_MocR) 		5 LEU A 333
SER A 336
LEU A 355
LEU A 329
LEU A 415
 None
 1.42A 4or0A-5c6uA:
undetectable		 4or0A-5c6uA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Arabidopsis
thaliana) 		PF02446
(Glyco_hydro_77) 		5 SER A  92
LEU A  87
ASP A 526
LEU A 530
LEU A  88
 None
 1.43A 4or0A-5csuA:
undetectable		 4or0A-5csuA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3m ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
delbrueckii) 		PF00005
(ABC_tran)
PF02361
(CbiQ) 		5 LEU B  56
ARG D 182
SER D 183
LEU B  57
LEU B  89
 None
 1.35A 4or0A-5d3mB:
undetectable		 4or0A-5d3mB:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 LEU A 197
SER A 201
LEU A 346
LEU A 454
LEU A 480
 None
None
CZE  A 613 ( 3.8A)
None
None
 0.95A 4or0A-5dqfA:
undetectable		 4or0A-5dqfA:
73.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqn CYTOCHROME P450
CYP125

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		5 ARG A 173
LEU A 176
SER A 180
LEU A 248
LEU A 203
 None
None
None
HEM  A 501 (-4.5A)
None
 1.44A 4or0A-5dqnA:
undetectable		 4or0A-5dqnA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr7 AMYR

(Erwinia
amylovora) 		PF10722
(YbjN) 		5 LEU A  14
ARG A  15
LEU A  36
ASP A  51
LEU A  52
 None
 1.37A 4or0A-5fr7A:
undetectable		 4or0A-5fr7A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzp DISPASE
AUTOLYSIS-INDUCING
PROTEIN

(Streptomyces
mobaraensis) 		no annotation 5 LEU A 105
ARG A  94
SER A 148
LEU A 116
LEU A 138
 None
 1.31A 4or0A-5fzpA:
undetectable		 4or0A-5fzpA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 LEU B1022
ARG B1099
LEU B1074
LEU B1019
LEU B1070
 None
 1.14A 4or0A-5hb4B:
undetectable		 4or0A-5hb4B:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 LEU B1029
SER B1110
LEU B1052
LEU B1103
LEU B1043
 None
 1.19A 4or0A-5hb4B:
undetectable		 4or0A-5hb4B:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 ARG A  56
LEU A  43
LEU A  67
LEU A  48
LEU A  77
 None
 1.46A 4or0A-5i2hA:
undetectable		 4or0A-5i2hA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 LEU A  29
SER A  33
LEU A  77
LEU A 313
LEU A  67
 None
 1.20A 4or0A-5i2hA:
undetectable		 4or0A-5i2hA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb1 MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
7) 		PF00500
(Late_protein_L1) 		5 LEU A 373
SER A  39
TRP A 448
LEU A 331
LEU A 452
 None
 1.40A 4or0A-5jb1A:
undetectable		 4or0A-5jb1A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 LEU A 129
ARG A 130
SER A 364
LEU A 365
LEU A 134
 None
 1.27A 4or0A-5jm7A:
undetectable		 4or0A-5jm7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Acidaminococcus
sp. BV3L6) 		no annotation 5 ARG A 341
LEU A 346
ASP A 451
LEU A 450
LEU A 443
 None
 1.32A 4or0A-5kk5A:
undetectable		 4or0A-5kk5A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kob PEPTIDE DEFORMYLASE

(Paraburkholderia
xenovorans) 		PF01327
(Pep_deformylase) 		5 ARG A  12
LEU A  13
ARG A  15
LEU A   6
LEU A 150
 None
 1.46A 4or0A-5kobA:
undetectable		 4or0A-5kobA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l94 CYTOCHROME P450

(Bacillus
megaterium) 		PF00067
(p450) 		5 LEU A 240
SER A 165
LEU A  80
LEU A 151
LEU A 194
 None
 1.23A 4or0A-5l94A:
undetectable		 4or0A-5l94A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3h POLYMERASE ACIDIC
PROTEIN

(Influenza A
virus) 		PF00603
(Flu_PA) 		5 LEU A 580
SER A 451
SER A 639
LEU A 581
LEU A 636
 None
 1.48A 4or0A-5m3hA:
undetectable		 4or0A-5m3hA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 LEU A 689
SER A 692
LEU A 709
LEU A 535
LEU A 693
 None
 1.36A 4or0A-5me3A:
undetectable		 4or0A-5me3A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		5 LEU A1285
SER A1386
LEU A1385
LEU A1269
LEU A1395
 None
 1.42A 4or0A-5mzoA:
undetectable		 4or0A-5mzoA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nj8 ARYL HYDROCARBON
RECEPTOR
ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR

(Homo sapiens) 		PF00010
(HLH)
PF00989
(PAS) 		5 ARG B 133
LEU B 132
ARG A  49
LEU B 129
LEU A  70
 None
 1.33A 4or0A-5nj8B:
undetectable		 4or0A-5nj8B:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oe5 ANTHRANILATE--COA
LIGASE

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		5 LEU A 243
ARG A 247
LEU A 295
LEU A 240
LEU A 251
 None
 1.29A 4or0A-5oe5A:
undetectable		 4or0A-5oe5A:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 6 ARG A 194
LEU A 197
ARG A 198
SER A 201
TRP A 213
LEU A 454
 None
 1.14A 4or0A-5oriA:
undetectable		 4or0A-5oriA:
91.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 6 LEU A 197
ARG A 198
SER A 201
TRP A 213
ARG A 217
LEU A 454
 None
 0.94A 4or0A-5oriA:
undetectable		 4or0A-5oriA:
91.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 8 LEU A 197
ARG A 198
SER A 201
TRP A 213
LEU A 346
ASP A 450
LEU A 454
LEU A 480
 None
 0.64A 4or0A-5oriA:
undetectable		 4or0A-5oriA:
91.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 8 LEU A 197
ARG A 198
SER A 201
TRP A 213
SER A 343
LEU A 346
LEU A 454
LEU A 480
 None
 0.59A 4or0A-5oriA:
undetectable		 4or0A-5oriA:
91.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svd NUCLEOLAR PROTEIN 9

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 LEU A 491
SER A 463
LEU A 466
LEU A 494
LEU A 465
 LEU  A 491 ( 0.6A)
SER  A 463 ( 0.0A)
LEU  A 466 ( 0.6A)
LEU  A 494 ( 0.6A)
LEU  A 465 ( 0.5A)
 1.46A 4or0A-5svdA:
undetectable		 4or0A-5svdA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5va4 TRIM5/CYCLOPHILIN A
V4 FUSION PROTEIN

(Aotus
trivirgatus;
Thermus
thermophilus) 		no annotation 5 LEU A 143
ARG A 221
ASP A 199
LEU A 200
LEU A 211
 None
 1.44A 4or0A-5va4A:
undetectable		 4or0A-5va4A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7c ACYLOXYACYL
HYDROLASE

(Homo sapiens) 		no annotation 5 LEU C 484
SER C 344
LEU C 347
ASP C 374
LEU C 480
 None
 1.44A 4or0A-5w7cC:
undetectable		 4or0A-5w7cC:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE

(Mus musculus) 		no annotation 5 LEU A 483
SER A 343
LEU A 346
ASP A 373
LEU A 479
 None
 1.43A 4or0A-5w7dA:
undetectable		 4or0A-5w7dA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 5 LEU A  67
SER A  63
ARG A1271
LEU A1084
LEU A1000
 None
 1.36A 4or0A-5wblA:
undetectable		 4or0A-5wblA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Homo sapiens) 		no annotation 5 LEU A 642
SER A 587
LEU A 590
LEU A 641
LEU A 655
 None
 1.32A 4or0A-5wp6A:
undetectable		 4or0A-5wp6A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1u UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 ARG A 315
LEU A 316
SER A 219
LEU A 285
LEU A 225
 None
 1.22A 4or0A-5x1uA:
undetectable		 4or0A-5x1uA:
17.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 LEU A 198
SER A 202
SER A 344
LEU A 347
ASP A 451
LEU A 481
 None
 0.93A 4or0A-5yxeA:
undetectable		 4or0A-5yxeA:
78.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a2f -

(-) 		no annotation 5 SER A 194
SER A 217
LEU A 230
ASP A 331
LEU A 340
 LLP  A  34 ( 2.5A)
None
None
None
None
 1.41A 4or0A-6a2fA:
undetectable		 4or0A-6a2fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE

(Legionella
pneumophila) 		no annotation 5 LEU A 147
ARG A 155
LEU A 184
LEU A 106
LEU A 165
 None
 1.19A 4or0A-6bs7A:
undetectable		 4or0A-6bs7A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 5 LEU A 734
ARG A 718
TRP A 720
LEU A 442
LEU A 713
 None
 1.36A 4or0A-6en4A:
undetectable		 4or0A-6en4A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fl0 -

(-) 		no annotation 5 LEU A  21
ARG A  64
ASP A 113
LEU A 116
LEU A 146
 None
 1.46A 4or0A-6fl0A:
undetectable		 4or0A-6fl0A:
undetectable