SIMILAR PATTERNS OF AMINO ACIDS FOR 4OR0_A_NPSA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akc ASPARTATE
AMINOTRANSFERASE


(Gallus gallus)
PF00155
(Aminotran_1_2)
5 ALA A 190
ALA A 239
LEU A 208
LEU A 252
VAL A 250
None
1.13A 4or0A-1akcA:
0.0
4or0A-1akcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea)
PF01070
(FMN_dh)
5 ALA A  91
ALA A  93
SER A 314
LEU A 315
VAL A 311
None
1.20A 4or0A-1al8A:
undetectable
4or0A-1al8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2y PROTEIN (LUMAZINE
SYNTHASE)


(Spinacia
oleracea)
PF00885
(DMRL_synthase)
5 ALA A  56
ALA A  21
LEU A  31
SER A  97
VAL A 100
LMZ  A 201 (-3.1A)
LMZ  A 201 ( 3.8A)
None
None
None
1.28A 4or0A-1c2yA:
undetectable
4or0A-1c2yA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis)
PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5)
5 ALA A 552
ALA A 554
LEU A 512
SER A 537
LEU A 538
None
1.37A 4or0A-1dgsA:
undetectable
4or0A-1dgsA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT


(Desulfovibrio
desulfuricans)
PF00374
(NiFeSe_Hases)
5 ALA B 132
ALA B 135
LEU B 143
LEU B 164
VAL B 160
None
1.30A 4or0A-1e3dB:
undetectable
4or0A-1e3dB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE


(Tetradesmus
obliquus)
PF03572
(Peptidase_S41)
PF13180
(PDZ_2)
5 ALA A 340
ALA A 417
LEU A 399
LEU A 338
VAL A 337
None
1.27A 4or0A-1fc9A:
1.1
4or0A-1fc9A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggm GLYCINE--TRNA LIGASE

(Thermus
thermophilus)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
5 PHE A 298
ALA A 373
ALA A 375
LEU A 369
VAL A 368
None
1.34A 4or0A-1ggmA:
undetectable
4or0A-1ggmA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxn PECTATE LYASE

(Cellvibrio
japonicus)
PF09492
(Pec_lyase)
5 ALA A 420
ALA A 419
LEU A 400
LEU A 461
VAL A 460
None
1.37A 4or0A-1gxnA:
undetectable
4or0A-1gxnA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h5y HISF

(Pyrobaculum
aerophilum)
PF00977
(His_biosynth)
5 ALA A 207
LEU A 225
SER A 236
LEU A 235
VAL A 240
PO4  A 302 ( 4.9A)
None
None
None
None
1.13A 4or0A-1h5yA:
undetectable
4or0A-1h5yA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hq0 CYTOTOXIC
NECROTIZING FACTOR 1


(Escherichia
coli)
PF05785
(CNF1)
5 PHE A 758
ALA A 760
ALA A 761
LEU A 904
VAL A 833
None
1.34A 4or0A-1hq0A:
undetectable
4or0A-1hq0A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv6 ALGINATE LYASE

(Sphingomonas
sp.)
PF05426
(Alginate_lyase)
5 ALA A 146
ALA A 149
LEU A  97
LEU A 171
VAL A 167
None
1.27A 4or0A-1hv6A:
undetectable
4or0A-1hv6A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II


(Thermus
thermophilus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 PHE A 405
ALA A 288
SER A 391
LEU A 403
VAL A 402
None
1.32A 4or0A-1j3nA:
undetectable
4or0A-1j3nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqv CYTOCHROME C'

(Rhodopseudomonas
palustris)
PF01322
(Cytochrom_C_2)
5 ALA A  45
ALA A  86
LEU A  51
SER A  40
LEU A  41
None
1.35A 4or0A-1mqvA:
2.8
4or0A-1mqvA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mxf PTERIDINE REDUCTASE
2


(Trypanosoma
cruzi)
PF13561
(adh_short_C2)
5 PHE A 251
ALA A 248
ALA A 246
LEU A 252
VAL A 253
None
1.20A 4or0A-1mxfA:
undetectable
4or0A-1mxfA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naa CELLOBIOSE
DEHYDROGENASE


(Phanerochaete
chrysosporium)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 ALA A 745
ALA A 741
LEU A 341
SER A 236
LEU A 235
None
1.34A 4or0A-1naaA:
undetectable
4or0A-1naaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE


(Pseudomonas sp.
CF600)
PF00682
(HMGL-like)
PF07836
(DmpG_comm)
5 ALA A 246
ALA A 244
LEU A 260
SER A 212
VAL A 209
None
1.29A 4or0A-1nvmA:
undetectable
4or0A-1nvmA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE


(Cryptococcus
neoformans)
PF00475
(IGPD)
5 PHE A 122
ALA A 149
ALA A 151
SER A 142
LEU A 145
EMC  A5501 (-4.3A)
None
None
None
None
1.28A 4or0A-1rhyA:
undetectable
4or0A-1rhyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t98 CHROMOSOME PARTITION
PROTEIN MUKF


(Escherichia
coli)
PF03882
(KicB)
PF17192
(MukF_M)
5 ALA A 143
ALA A 139
LEU A 136
LEU A 246
VAL A 249
None
1.30A 4or0A-1t98A:
2.4
4or0A-1t98A:
18.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
7 ARG A 209
ALA A 210
ALA A 213
LEU A 327
SER A 480
LEU A 481
VAL A 482
DKA  A1001 ( 4.6A)
DKA  A1002 (-3.3A)
DKA  A1001 ( 4.0A)
DKA  A1001 (-4.1A)
DKA  A1002 (-3.4A)
None
DKA  A1002 (-4.2A)
0.70A 4or0A-1tf0A:
45.0
4or0A-1tf0A:
76.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
7 ARG A 209
ALA A 210
LEU A 327
LYS A 351
SER A 480
LEU A 481
VAL A 482
DKA  A1001 ( 4.6A)
DKA  A1002 (-3.3A)
DKA  A1001 (-4.1A)
DKA  A1002 (-2.6A)
DKA  A1002 (-3.4A)
None
DKA  A1002 (-4.2A)
0.93A 4or0A-1tf0A:
45.0
4or0A-1tf0A:
76.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
6 PHE A 206
ALA A 210
ALA A 213
SER A 480
LEU A 481
VAL A 482
None
DKA  A1002 (-3.3A)
DKA  A1001 ( 4.0A)
DKA  A1002 (-3.4A)
None
DKA  A1002 (-4.2A)
0.85A 4or0A-1tf0A:
45.0
4or0A-1tf0A:
76.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xty PEPTIDYL-TRNA
HYDROLASE


(Sulfolobus
solfataricus)
PF01981
(PTH2)
5 ALA A  26
ALA A  24
SER A  33
LEU A  30
VAL A  31
None
1.38A 4or0A-1xtyA:
undetectable
4or0A-1xtyA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp1 FII

(Deinagkistrodon
acutus)
PF01421
(Reprolysin)
5 PHE A 112
ALA A 123
ALA A  95
SER A  76
LEU A  75
None
1.24A 4or0A-1yp1A:
undetectable
4or0A-1yp1A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwp 5-AMINOLEVULINATE
SYNTHASE


(Rhodobacter
capsulatus)
PF00155
(Aminotran_1_2)
5 ALA A 285
ALA A 286
LEU A  73
LEU A 246
VAL A 252
None
1.11A 4or0A-2bwpA:
undetectable
4or0A-2bwpA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Staphylococcus
aureus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 PHE A 409
ALA A 291
SER A 395
LEU A 407
VAL A 406
None
1.17A 4or0A-2gqdA:
undetectable
4or0A-2gqdA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdx SH2-B PH DOMAIN
CONTAINING SIGNALING
MEDIATOR 1 GAMMA
ISOFORM


(Mus musculus)
PF00017
(SH2)
5 PHE A 568
ALA A 537
LEU A 535
LEU A 566
VAL A 565
None
1.17A 4or0A-2hdxA:
undetectable
4or0A-2hdxA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING


(Lactococcus
lactis)
PF00393
(6PGD)
PF03446
(NAD_binding_2)
5 PHE A 156
ALA A 160
ALA A 161
LEU A 136
VAL A 127
None
1.27A 4or0A-2iyoA:
undetectable
4or0A-2iyoA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00156
(Pribosyltran)
5 PHE A  81
ALA A 199
SER A 169
LEU A 170
VAL A 143
CAS  A  82 ( 4.7A)
None
None
None
5GP  A1230 (-4.0A)
1.11A 4or0A-2jbhA:
undetectable
4or0A-2jbhA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kq9 DNAK SUPPRESSOR
PROTEIN


(Agrobacterium
fabrum)
PF01258
(zf-dskA_traR)
5 ALA A  72
ALA A  68
LEU A  66
LEU A  96
VAL A  99
None
1.37A 4or0A-2kq9A:
undetectable
4or0A-2kq9A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE


(Thermus
thermophilus)
PF13561
(adh_short_C2)
5 PHE A 222
ALA A 219
ALA A 217
LEU A 223
VAL A 224
None
1.19A 4or0A-2ph3A:
undetectable
4or0A-2ph3A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN


(Staphylococcus
epidermidis)
PF01933
(UPF0052)
5 PHE A  75
ALA A  62
ALA A  63
LEU A  15
LEU A 115
None
1.32A 4or0A-2ppvA:
undetectable
4or0A-2ppvA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7d RIBONUCLEASE II
FAMILY PROTEIN


(Deinococcus
radiodurans)
PF00773
(RNB)
5 ALA A  39
ALA A  42
SER A  25
LEU A  17
VAL A  14
None
1.06A 4or0A-2r7dA:
undetectable
4or0A-2r7dA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE


(Bacillus
subtilis)
PF01979
(Amidohydro_1)
5 ALA A 198
ALA A 218
LEU A 210
SER A 156
LEU A 187
None
1.17A 4or0A-2vhlA:
undetectable
4or0A-2vhlA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ


(Escherichia
coli)
PF13407
(Peripla_BP_4)
5 ALA A 252
ALA A 255
LEU A  88
LEU A  35
VAL A   5
None
1.38A 4or0A-2vk2A:
undetectable
4or0A-2vk2A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wae PENICILLIN-BINDING
PROTEIN 2B


(Streptococcus
pneumoniae)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
5 PHE A 316
ALA A  66
LEU A  71
LEU A 356
VAL A 355
None
1.34A 4or0A-2waeA:
undetectable
4or0A-2waeA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhl PUTATIVE
OXIDOREDUCTASE


(Bacteroides
fragilis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 ALA A  80
ALA A  83
LEU A  58
SER A 118
LEU A 117
None
1.12A 4or0A-3fhlA:
undetectable
4or0A-3fhlA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h75 PERIPLASMIC
SUGAR-BINDING DOMAIN
PROTEIN


(Pseudomonas
protegens)
PF13407
(Peripla_BP_4)
5 ALA A 253
ALA A 256
LEU A 185
SER A 292
LEU A 291
None
1.25A 4or0A-3h75A:
undetectable
4or0A-3h75A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kr9 SAM-DEPENDENT
METHYLTRANSFERASE


(Streptococcus
pneumoniae)
PF04816
(TrmK)
5 PHE A  79
ARG A  71
ALA A  78
ALA A  73
LEU A  76
None
1.39A 4or0A-3kr9A:
undetectable
4or0A-3kr9A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmo SPECIALIZED ACYL
CARRIER PROTEIN


(Rhodopseudomonas
palustris)
PF00550
(PP-binding)
5 PHE A   5
ALA A  81
ALA A  82
LEU A  77
VAL A  76
None
1.18A 4or0A-3lmoA:
undetectable
4or0A-3lmoA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbk FATTY ACYL-ADENYLATE
LIGASE


(Escherichia
coli)
PF00501
(AMP-binding)
5 ALA A  59
ALA A  63
LEU A  99
LEU A  27
VAL A  24
None
1.37A 4or0A-3pbkA:
undetectable
4or0A-3pbkA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbk FATTY ACYL-ADENYLATE
LIGASE


(Escherichia
coli)
PF00501
(AMP-binding)
5 PHE A  92
ALA A  59
ALA A  63
LEU A  27
VAL A  24
None
1.27A 4or0A-3pbkA:
undetectable
4or0A-3pbkA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN


(Leishmania
infantum)
PF00857
(Isochorismatase)
5 ALA A 166
ALA A 169
LEU A 143
LEU A 178
VAL A 177
None
1.37A 4or0A-3r2jA:
undetectable
4or0A-3r2jA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9s CARNITINYL-COA
DEHYDRATASE


(Mycobacterium
avium)
PF00378
(ECH_1)
5 PHE A  63
ALA A 128
ALA A 170
LEU A 168
VAL A 122
None
1.36A 4or0A-3r9sA:
undetectable
4or0A-3r9sA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6


(Homo sapiens)
PF00856
(SET)
PF09273
(Rubis-subs-bind)
5 ALA A 271
ALA A 258
LEU A 260
SER A  37
VAL A  64
None
1.27A 4or0A-3rc0A:
undetectable
4or0A-3rc0A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7w EIGHT-HEME NITRITE
REDUCTASE


(Thioalkalivibrio
nitratireducens)
PF02335
(Cytochrom_C552)
5 PHE A 452
ALA A 455
ALA A 458
LEU A 465
VAL A 464
None
1.20A 4or0A-3s7wA:
2.1
4or0A-3s7wA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttb EIGHT-HEME NITRITE
REDUCTASE


(Thioalkalivibrio
paradoxus)
PF02335
(Cytochrom_C552)
5 PHE A 452
ALA A 455
ALA A 458
LEU A 465
VAL A 464
None
1.22A 4or0A-3ttbA:
undetectable
4or0A-3ttbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpj TON_1535

(Thermococcus
onnurineus)
no annotation 5 PHE A  97
ALA A 100
ALA A  74
LEU A  67
SER A  82
None
1.29A 4or0A-3zpjA:
undetectable
4or0A-3zpjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga)
PF00704
(Glyco_hydro_18)
5 PHE A 459
ALA A 383
ALA A 405
SER A 336
LEU A 335
None
1.13A 4or0A-4a5qA:
undetectable
4or0A-4a5qA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bms ALCLOHOL
DEHYDROGENASE/SHORT-
CHAIN DEHYDROGENASE


(Ralstonia sp.
DSMZ 6428)
PF13561
(adh_short_C2)
5 PHE A 226
ALA A 223
ALA A 221
SER A 232
LEU A 227
None
1.34A 4or0A-4bmsA:
undetectable
4or0A-4bmsA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3y DIHYDRODIPICOLINATE
REDUCTASE


(Burkholderia
thailandensis)
PF01113
(DapB_N)
PF05173
(DapB_C)
5 ALA A  47
ALA A  11
LEU A  35
LEU A  24
VAL A  23
None
1.18A 4or0A-4f3yA:
undetectable
4or0A-4f3yA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgs PROBABLE
DEHYDROGENASE
PROTEIN


(Rhizobium etli)
PF13561
(adh_short_C2)
5 PHE A 228
ALA A 225
ALA A 223
SER A 234
LEU A 229
None
1.35A 4or0A-4fgsA:
undetectable
4or0A-4fgsA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtu GLUTATHIONE
S-TRANSFERASE


(Homo sapiens)
PF02798
(GST_N)
PF14497
(GST_C_3)
5 PHE A 157
ALA A  15
ALA A  13
LEU A 203
LEU A  19
None
1.24A 4or0A-4gtuA:
undetectable
4or0A-4gtuA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2


(Streptococcus
pneumoniae)
PF12849
(PBP_like_2)
5 PHE A 165
ALA A 254
ALA A 252
LEU A 195
VAL A 192
None
0.88A 4or0A-4h1xA:
undetectable
4or0A-4h1xA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hht RIBONUCLEASE HII

(Thermotoga
maritima)
PF01351
(RNase_HII)
5 ALA A  32
ALA A  93
LEU A 113
SER A  21
VAL A  29
None
None
None
C  D   6 ( 4.7A)
None
1.35A 4or0A-4hhtA:
undetectable
4or0A-4hhtA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 PHE A 324
ALA A 255
LEU A 253
SER A 230
LEU A 229
None
1.35A 4or0A-4id7A:
undetectable
4or0A-4id7A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf8 NUP188

(Thermothelomyces
thermophila)
no annotation 5 ALA A1660
ALA A1657
LEU A1785
SER A1695
LEU A1692
None
1.37A 4or0A-4kf8A:
undetectable
4or0A-4kf8A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kms ACETOACETYL-COA
REDUCTASE


(Rickettsia
felis)
PF13561
(adh_short_C2)
5 PHE A 218
ALA A 215
ALA A 213
LEU A 219
VAL A 220
None
1.21A 4or0A-4kmsA:
undetectable
4or0A-4kmsA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpu ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT


(Acidaminococcus
fermentans)
PF01012
(ETF)
5 PHE B 239
ALA B 247
ALA B 245
LEU B 251
VAL B 252
None
1.13A 4or0A-4kpuB:
undetectable
4or0A-4kpuB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN


(Thermococcus
onnurineus)
PF13646
(HEAT_2)
5 ALA A 117
ALA A 116
SER A 140
LEU A 139
VAL A 138
None
1.08A 4or0A-4l7mA:
2.6
4or0A-4l7mA:
18.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
6 ALA A 210
ALA A 213
LYS A 351
SER A 480
LEU A 481
VAL A 482
None
NPS  A 602 (-3.3A)
None
None
None
None
0.84A 4or0A-4po0A:
50.1
4or0A-4po0A:
71.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
6 ALA A 213
LEU A 327
LYS A 351
SER A 480
LEU A 481
VAL A 482
NPS  A 602 (-3.3A)
NPS  A 602 ( 4.7A)
None
None
None
None
0.76A 4or0A-4po0A:
50.1
4or0A-4po0A:
71.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
6 ARG A 209
ALA A 210
ALA A 213
SER A 480
LEU A 481
VAL A 482
NPS  A 602 (-3.6A)
None
NPS  A 602 (-3.3A)
None
None
None
0.82A 4or0A-4po0A:
50.1
4or0A-4po0A:
71.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
6 ARG A 209
ALA A 213
LEU A 327
SER A 480
LEU A 481
VAL A 482
NPS  A 602 (-3.6A)
NPS  A 602 (-3.3A)
NPS  A 602 ( 4.7A)
None
None
None
1.02A 4or0A-4po0A:
50.1
4or0A-4po0A:
71.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
6 PHE A 206
ALA A 210
ALA A 213
SER A 480
LEU A 481
VAL A 482
None
None
NPS  A 602 (-3.3A)
None
None
None
0.68A 4or0A-4po0A:
50.1
4or0A-4po0A:
71.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxt SUGAR ABC
TRANSPORTER


(Agrobacterium
tumefaciens)
PF13407
(Peripla_BP_4)
5 ALA A 235
ALA A 229
LEU A 177
LEU A 274
VAL A 275
None
None
ARA  A 401 ( 4.6A)
None
None
1.32A 4or0A-4rxtA:
undetectable
4or0A-4rxtA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN


(Salmonella
enterica)
PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1)
5 ALA A1421
ALA A1425
LEU A1386
SER A1376
LEU A1377
None
1.37A 4or0A-4u48A:
2.7
4or0A-4u48A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE


(Methylovorus
sp. MP688)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 ALA A 524
ALA A 520
LEU A 517
SER A  25
LEU A  24
None
1.24A 4or0A-4udrA:
undetectable
4or0A-4udrA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcd PTERIDINE REDUCTASE

(Trypanosoma
brucei)
PF13561
(adh_short_C2)
5 PHE A 243
ALA A 240
ALA A 238
LEU A 244
VAL A 245
None
1.15A 4or0A-4wcdA:
undetectable
4or0A-4wcdA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE


(Sulfolobus
acidocaldarius)
PF00180
(Iso_dh)
5 ALA A  98
ALA A 235
LEU A 101
SER A 243
VAL A 256
None
1.37A 4or0A-4y1pA:
undetectable
4or0A-4y1pA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE


(Thermosynechococcus
elongatus)
PF03320
(FBPase_glpX)
5 ALA A 232
ALA A 231
LEU A 285
LEU A 205
VAL A 201
None
1.17A 4or0A-5a5lA:
undetectable
4or0A-5a5lA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SCARECROW

(Arabidopsis
thaliana)
PF03514
(GRAS)
5 ALA A 298
ALA A 300
LEU A 306
SER A 529
LEU A 531
None
1.34A 4or0A-5b3hA:
2.7
4or0A-5b3hA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmx D-ALANINE--D-ALANINE
LIGASE


(Acinetobacter
baumannii)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
5 ALA A  30
ALA A  34
LEU A 295
SER A  24
VAL A  64
None
1.38A 4or0A-5dmxA:
undetectable
4or0A-5dmxA:
19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
5 ALA A 209
ALA A 212
LEU A 326
SER A 479
LEU A 480
CZE  A 613 ( 4.4A)
CZE  A 613 ( 3.7A)
CZE  A 613 ( 4.7A)
None
None
1.02A 4or0A-5dqfA:
50.6
4or0A-5dqfA:
73.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
5 ALA A 209
LEU A 326
LYS A 350
SER A 479
LEU A 480
CZE  A 613 ( 4.4A)
CZE  A 613 ( 4.7A)
CZE  A 613 (-4.1A)
None
None
1.13A 4or0A-5dqfA:
50.6
4or0A-5dqfA:
73.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
5 PHE A 205
ALA A 209
ALA A 212
SER A 479
LEU A 480
None
CZE  A 613 ( 4.4A)
CZE  A 613 ( 3.7A)
None
None
0.89A 4or0A-5dqfA:
50.6
4or0A-5dqfA:
73.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
5 PHE A 205
ARG A 208
ALA A 209
ALA A 212
LEU A 480
None
CZE  A 613 ( 3.5A)
CZE  A 613 ( 4.4A)
CZE  A 613 ( 3.7A)
None
0.90A 4or0A-5dqfA:
50.6
4or0A-5dqfA:
73.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epv BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE


(Brucella
abortus)
PF07536
(HWE_HK)
5 ALA A 394
ALA A 389
LEU A 385
SER A 461
VAL A 429
None
ACP  A 501 ( 4.4A)
None
None
ACP  A 501 ( 4.2A)
1.31A 4or0A-5epvA:
2.1
4or0A-5epvA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exk LIPOYL SYNTHASE

(Mycobacterium
tuberculosis)
PF04055
(Radical_SAM)
PF16881
(LIAS_N)
5 ALA A 210
ALA A 206
LEU A 204
SER A 172
VAL A 169
None
1.07A 4or0A-5exkA:
undetectable
4or0A-5exkA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P


(Lachancea
thermotolerans)
no annotation 5 PHE A 417
ALA A 456
ALA A 458
LEU A 438
VAL A 439
None
1.39A 4or0A-5f0oA:
2.1
4or0A-5f0oA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum)
PF03568
(Peptidase_C50)
5 ALA A2137
LEU A1988
SER A2184
LEU A2185
VAL A2186
None
0.89A 4or0A-5fbyA:
undetectable
4or0A-5fbyA:
22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
5 ALA A 210
ALA A 213
LEU A 327
LEU A 481
VAL A 482
None
0.87A 4or0A-5ghkA:
46.8
4or0A-5ghkA:
76.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
5 PHE A 206
ALA A 210
ALA A 213
LEU A 481
VAL A 482
None
0.98A 4or0A-5ghkA:
46.8
4or0A-5ghkA:
76.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S


(Oryctolagus
cuniculus)
PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH)
5 ALA A 660
LEU A 562
SER A 334
LEU A 333
VAL A 332
None
1.20A 4or0A-5gjvA:
undetectable
4or0A-5gjvA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME


(Brucella
melitensis)
PF01053
(Cys_Met_Meta_PP)
5 ALA A 253
ALA A 110
LYS A 265
SER A 100
LEU A 255
None
1.14A 4or0A-5ijgA:
undetectable
4or0A-5ijgA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE


(Corynebacterium
glutamicum)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 PHE A 262
ALA A 245
ALA A 248
LEU A 280
VAL A 277
None
1.27A 4or0A-5ijzA:
undetectable
4or0A-5ijzA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldn HEXON PROTEIN,HEXON
CAPSID


(Human
mastadenovirus
C)
PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C)
5 ARG A  32
ALA A  31
ALA A  33
SER A  24
LEU A  27
None
1.19A 4or0A-5ldnA:
undetectable
4or0A-5ldnA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN


(Thermus
thermophilus)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
5 ALA A 390
ALA A 553
LEU A 556
LEU A 566
VAL A 567
None
1.16A 4or0A-5mkkA:
3.4
4or0A-5mkkA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nux CHROMATE REDUCTASE

(Thermus
scotoductus)
no annotation 5 PHE A 154
ALA A 158
ALA A 161
LEU A  83
LEU A 171
None
1.31A 4or0A-5nuxA:
undetectable
4or0A-5nuxA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1


(Saccharomyces
cerevisiae)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
5 ALA T1148
ALA T1152
LEU T1200
SER T1143
LEU T1144
None
1.39A 4or0A-5ojsT:
undetectable
4or0A-5ojsT:
9.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 7 PHE A 205
ARG A 208
ALA A 209
ALA A 212
LEU A 326
LEU A 480
VAL A 481
None
0.74A 4or0A-5oriA:
52.3
4or0A-5oriA:
91.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 7 PHE A 205
ARG A 208
ALA A 209
LEU A 326
SER A 479
LEU A 480
VAL A 481
None
0.97A 4or0A-5oriA:
52.3
4or0A-5oriA:
91.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xon TRANSCRIPTION
ELONGATION FACTOR
SPT4


(Komagataella
phaffii)
PF06093
(Spt4)
5 ALA V  83
ALA V  11
LEU V  19
LEU V  72
VAL V  74
None
1.35A 4or0A-5xonV:
undetectable
4or0A-5xonV:
12.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 7 PHE A 206
ARG A 209
ALA A 210
ALA A 213
LEU A 327
LEU A 481
VAL A 482
None
0.80A 4or0A-5yxeA:
44.5
4or0A-5yxeA:
78.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 5 PHE A 206
LEU A 327
SER A 480
LEU A 481
VAL A 482
None
1.10A 4or0A-5yxeA:
44.5
4or0A-5yxeA:
78.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER


(Homo sapiens)
no annotation 5 PHE A1812
ALA A1816
ALA A1818
LEU A1683
VAL A1833
None
1.36A 4or0A-5zalA:
2.7
4or0A-5zalA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2


(Homo sapiens)
no annotation 5 PHE A 267
ALA A 192
ALA A 182
LEU A 162
VAL A 252
BI9  A 501 ( 4.2A)
BI9  A 501 (-3.3A)
None
None
None
1.31A 4or0A-6bqlA:
2.5
4or0A-6bqlA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S


(Oryctolagus
cuniculus)
no annotation 5 ALA A 660
ALA A 658
SER A 334
LEU A 333
VAL A 332
None
1.24A 4or0A-6byoA:
undetectable
4or0A-6byoA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S


(Oryctolagus
cuniculus)
no annotation 5 ALA A 660
LEU A 562
SER A 334
LEU A 333
VAL A 332
None
1.16A 4or0A-6byoA:
undetectable
4or0A-6byoA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1


(Mus musculus)
no annotation 5 PHE A 622
ALA A 554
LEU A 659
SER A 623
LEU A 655
None
1.27A 4or0A-6cg0A:
2.8
4or0A-6cg0A:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2


(Homo sapiens)
no annotation 5 PHE A 267
ALA A 192
ALA A 182
LEU A 162
VAL A 252
F6J  A 501 (-3.7A)
F6J  A 501 (-3.4A)
None
None
None
1.38A 4or0A-6cmjA:
2.4
4or0A-6cmjA:
9.20