SIMILAR PATTERNS OF AMINO ACIDS FOR 4OR0_A_NPSA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 TYR A 668
GLY A 687
THR A 564
LEU A 744
SER A 572
 None
 1.30A 4or0A-1bf2A:
0.0		 4or0A-1bf2A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt4 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF00266
(Aminotran_5) 		5 PHE A 162
ARG A 181
THR A 100
LEU A 131
SER A 296
 None
 1.22A 4or0A-1bt4A:
undetectable		 4or0A-1bt4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		5 ARG A  20
VAL A 147
GLY A 149
LEU A 130
SER A 155
 None
 1.36A 4or0A-1ipaA:
undetectable		 4or0A-1ipaA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvh CRYPTIC LOCI
REGULATOR 4

(Schizosaccharomyces
pombe) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 TYR A 451
VAL A 396
GLY A 359
LEU A 385
SER A 420
 None
 1.41A 4or0A-1mvhA:
undetectable		 4or0A-1mvhA:
17.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		9 ASN A 391
PHE A 403
ARG A 410
TYR A 411
LYS A 414
VAL A 433
GLY A 434
LEU A 453
SER A 489
 None
 0.74A 4or0A-1tf0A:
45.0		 4or0A-1tf0A:
76.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 VAL A 113
GLY A 109
THR A 115
LEU A 250
SER A 259
 None
 1.47A 4or0A-2bpqA:
0.9		 4or0A-2bpqA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 VAL A 113
GLY A 110
THR A 115
LEU A 250
SER A 259
 None
 1.48A 4or0A-2bpqA:
0.9		 4or0A-2bpqA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ASN A 381
VAL A 453
GLY A 427
THR A 455
LEU A 513
 None
 1.47A 4or0A-2e6kA:
1.7		 4or0A-2e6kA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 VAL A 135
GLY A 134
CYH A 132
LEU A  99
SER A   6
 None
 1.41A 4or0A-2fpgA:
undetectable		 4or0A-2fpgA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 VAL A 184
GLY A 185
CYH A 132
LEU A  10
SER A   6
 None
 1.38A 4or0A-2fpgA:
undetectable		 4or0A-2fpgA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 PHE A 353
GLY A 351
THR A 511
LEU A 484
SER A 383
 None
 1.34A 4or0A-2okjA:
0.4		 4or0A-2okjA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 PHE A 344
GLY A 342
THR A 502
LEU A 475
SER A 374
 None
 1.36A 4or0A-2okkA:
0.7		 4or0A-2okkA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbk TAILSPIKE-PROTEIN

(Shigella virus
Sf6) 		PF12708
(Pectate_lyase_3) 		5 VAL A 281
GLY A 302
CYH A 326
LEU A 242
SER A 238
 None
 1.42A 4or0A-2vbkA:
undetectable		 4or0A-2vbkA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		5 ASN A 443
PHE A 168
VAL A 171
GLY A 439
LEU A 228
 None
 1.24A 4or0A-3cj1A:
undetectable		 4or0A-3cj1A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek1 ALDEHYDE
DEHYDROGENASE

(Brucella
abortus) 		PF00171
(Aldedh) 		5 ASN A 321
PHE A 366
GLY A 330
THR A  96
SER A  38
 None
 1.26A 4or0A-3ek1A:
undetectable		 4or0A-3ek1A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl1 FERRITIN LIKE
PROTEIN

(Caulobacter
vibrioides) 		PF12902
(Ferritin-like) 		5 TYR A  27
VAL A 312
GLY A 251
THR A 253
SER A 103
 None
 1.36A 4or0A-3hl1A:
undetectable		 4or0A-3hl1A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP3
U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF06544
(DUF1115)
PF08572
(PRP3) 		5 VAL K 383
GLY K 384
CYH K 389
LEU K 432
SER B 349
 None
 1.36A 4or0A-3jcmK:
undetectable		 4or0A-3jcmK:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r79 UNCHARACTERIZED
PROTEIN

(Agrobacterium
fabrum) 		PF01168
(Ala_racemase_N) 		5 ARG A 211
VAL A 128
GLY A 138
THR A 130
LEU A 179
 None
 1.06A 4or0A-3r79A:
undetectable		 4or0A-3r79A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsj VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 3

(Homo sapiens) 		no annotation 5 TYR A 448
LYS A 514
VAL A 540
GLY A 541
THR A 346
 None
 1.46A 4or0A-4bsjA:
undetectable		 4or0A-4bsjA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fch OUTER MEMBRANE
PROTEIN SUSE

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE) 		5 TYR A 281
LYS A 242
VAL A 201
GLY A 200
LEU A 333
 None
 1.34A 4or0A-4fchA:
undetectable		 4or0A-4fchA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Streptococcus
pneumoniae) 		PF01259
(SAICAR_synt) 		5 VAL A  65
GLY A  64
THR A  67
LEU A 189
SER A  53
 144  A 307 ( 4.3A)
144  A 304 ( 3.6A)
None
None
None
 1.48A 4or0A-4fe2A:
undetectable		 4or0A-4fe2A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis) 		PF04909
(Amidohydro_2) 		5 ASN A 143
TYR A  39
VAL A  80
THR A 115
LEU A  75
 None
 1.48A 4or0A-4ng3A:
undetectable		 4or0A-4ng3A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis) 		PF04909
(Amidohydro_2) 		5 PHE A  83
TYR A  39
GLY A  88
THR A 115
LEU A  75
 None
 1.48A 4or0A-4ng3A:
undetectable		 4or0A-4ng3A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 PHE A1029
VAL A 802
GLY A 803
THR A 843
SER A 974
 None
 0.90A 4or0A-4nh0A:
undetectable		 4or0A-4nh0A:
20.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		9 ASN A 391
PHE A 403
ARG A 410
TYR A 411
LYS A 414
VAL A 433
GLY A 434
LEU A 453
SER A 489
 NPS  A 601 (-4.3A)
None
NPS  A 601 (-4.5A)
NPS  A 601 (-4.3A)
NPS  A 601 (-2.7A)
None
None
NPS  A 601 (-4.7A)
NPS  A 601 (-3.1A)
 0.53A 4or0A-4po0A:
50.1		 4or0A-4po0A:
71.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s13 FERULIC ACID
DECARBOXYLASE 1

(Saccharomyces
cerevisiae) 		PF01977
(UbiD) 		5 PHE A  53
VAL A 316
GLY A  68
CYH A  69
LEU A 144
 None
 1.16A 4or0A-4s13A:
undetectable		 4or0A-4s13A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v15 D-THREONINE ALDOLASE

(Achromobacter
xylosoxidans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		5 ASN A 127
VAL A 160
GLY A 159
CYH A 158
LEU A 169
 None
 1.43A 4or0A-4v15A:
undetectable		 4or0A-4v15A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		5 LYS A 503
VAL A 181
GLY A 180
THR A 185
LEU A 190
 None
 1.33A 4or0A-5bp8A:
1.2		 4or0A-5bp8A:
22.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		8 ASN A 390
PHE A 402
ARG A 409
LYS A 413
VAL A 432
GLY A 433
LEU A 452
SER A 488
 None
 0.83A 4or0A-5dqfA:
50.6		 4or0A-5dqfA:
73.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		8 ASN A 390
PHE A 402
ARG A 409
TYR A 410
LYS A 413
VAL A 432
GLY A 433
SER A 488
 None
 0.73A 4or0A-5dqfA:
50.6		 4or0A-5dqfA:
73.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		9 ASN A 391
PHE A 403
ARG A 410
TYR A 411
LYS A 414
VAL A 433
GLY A 434
LEU A 453
SER A 489
 None
 0.67A 4or0A-5ghkA:
46.8		 4or0A-5ghkA:
76.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k51 HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Trypanosoma
brucei) 		PF00156
(Pribosyltran) 		5 TYR A 157
VAL A  72
GLY A  68
THR A  74
LEU A  47
 None
 1.43A 4or0A-5k51A:
undetectable		 4or0A-5k51A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Streptomyces
venezuelae) 		PF00982
(Glyco_transf_20) 		5 ARG A 244
VAL A 252
GLY A 253
THR A 257
LEU A 294
 None
 1.31A 4or0A-5lqdA:
undetectable		 4or0A-5lqdA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 5 ASN A 341
GLY A 343
THR A 407
LEU A 410
SER A 370
 None
 1.21A 4or0A-5oasA:
undetectable		 4or0A-5oasA:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 10 ASN A 390
PHE A 402
ARG A 409
TYR A 410
LYS A 413
VAL A 432
GLY A 433
THR A 448
LEU A 452
SER A 488
 None
 0.74A 4or0A-5oriA:
52.3		 4or0A-5oriA:
91.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu1 ABC TRANSPORTER
PERMEAE

(Streptococcus
pneumoniae) 		no annotation 5 VAL M 307
GLY M 306
THR M  21
LEU M 346
SER M  10
 None
 1.33A 4or0A-5xu1M:
undetectable		 4or0A-5xu1M:
7.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 9 ASN A 391
PHE A 403
ARG A 410
TYR A 411
LYS A 414
VAL A 433
GLY A 434
LEU A 453
SER A 489
 None
 0.79A 4or0A-5yxeA:
44.5		 4or0A-5yxeA:
78.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6al7 12-EPI-HAPALINDOLE
C/U SYNTHASE

(Fischerella sp.
ATCC 43239) 		no annotation 5 ASN A  77
PHE A 115
VAL A  79
GLY A 100
THR A  50
 None
 1.49A 4or0A-6al7A:
undetectable		 4or0A-6al7A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cph TCR BETA CHAIN

(Homo sapiens) 		no annotation 5 PHE E 230
TYR E 204
VAL E  12
GLY E 232
LEU E 130
 None
 1.24A 4or0A-6cphE:
undetectable		 4or0A-6cphE:
9.81