SIMILAR PATTERNS OF AMINO ACIDS FOR 4OQR_A_2UOA502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		5 VAL A 324
ILE A 187
ALA A 163
THR A 281
ALA A 303
 None
 1.15A 4oqrA-1a2oA:
0.0		 4oqrA-1a2oA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chd CHEB METHYLESTERASE

(Salmonella
enterica) 		PF01339
(CheB_methylest) 		5 VAL A 324
ILE A 187
ALA A 163
THR A 281
ALA A 303
 None
 1.18A 4oqrA-1chdA:
undetectable		 4oqrA-1chdA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 VAL A 417
ILE A 430
VAL A 264
ALA A 263
ALA A 280
 None
 1.22A 4oqrA-1ezvA:
0.0		 4oqrA-1ezvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		5 PRO A 150
ILE A 163
VAL A 174
ALA A 172
ALA A 271
 None
 1.27A 4oqrA-1h39A:
0.0		 4oqrA-1h39A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 ILE A  69
ALA A  67
THR A  65
VAL A 191
ALA A 193
 None
 1.08A 4oqrA-1i7oA:
0.0		 4oqrA-1i7oA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 344
VAL A   4
ALA A   3
VAL A  32
ALA A  35
 None
 1.24A 4oqrA-1jvbA:
undetectable		 4oqrA-1jvbA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 VAL A 241
ILE A 316
VAL A 411
ALA A 410
ALA A 311
 None
 1.27A 4oqrA-1kfiA:
0.0		 4oqrA-1kfiA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 VAL A 184
ILE A 225
ALA A 228
VAL A 200
ALA A 182
 None
 1.31A 4oqrA-1knrA:
0.0		 4oqrA-1knrA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n9b BETA-LACTAMASE SHV-2

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		5 PRO A 183
VAL A  44
ILE A 260
VAL A 247
ALA A 248
 None
None
None
None
MA4  A 300 (-3.4A)
 1.16A 4oqrA-1n9bA:
undetectable		 4oqrA-1n9bA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzy 4-CHLOROBENZOYL
COENZYME A
DEHALOGENASE

(Pseudomonas sp.
CBS3) 		PF00378
(ECH_1) 		5 PRO B 102
VAL B  48
ILE B  97
THR B  36
ALA B  42
 None
 1.31A 4oqrA-1nzyB:
undetectable		 4oqrA-1nzyB:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or7 RNA POLYMERASE
SIGMA-E FACTOR
SIGMA-E FACTOR
NEGATIVE REGULATORY
PROTEIN

(Escherichia
coli) 		PF03872
(RseA_N)
PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2) 		5 ILE C  55
VAL A  33
ALA A  34
VAL A  41
ALA A  82
 None
 1.18A 4oqrA-1or7C:
undetectable		 4oqrA-1or7C:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3s THERMOSOME ALPHA
SUBUNIT

(Thermococcus
sp. JCM 11816) 		PF00118
(Cpn60_TCP1) 		5 ILE A 332
ALA A 330
THR A 328
VAL A 219
ALA A 371
 None
 1.21A 4oqrA-1q3sA:
undetectable		 4oqrA-1q3sA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw9 CHONDROITIN AC LYASE

(Paenarthrobacter
aurescens) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 PRO A 715
ILE A 753
ALA A 699
THR A 478
ALA A 668
 None
 1.19A 4oqrA-1rw9A:
undetectable		 4oqrA-1rw9A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1se8 SINGLE-STRAND
BINDING PROTEIN

(Deinococcus
radiodurans) 		PF00436
(SSB) 		5 VAL A 223
ILE A 144
VAL A 153
ALA A 152
ALA A 225
 None
 1.15A 4oqrA-1se8A:
undetectable		 4oqrA-1se8A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		5 ILE A 221
ALA A 285
THR A 283
VAL A 247
ALA A 237
 None
 1.31A 4oqrA-1smrA:
undetectable		 4oqrA-1smrA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		5 ILE A 328
VAL A 256
ALA A 326
THR A 385
ALA A 280
 None
 1.28A 4oqrA-1su7A:
undetectable		 4oqrA-1su7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvp CELLULASE

(Pseudoalteromonas
haloplanktis) 		PF00150
(Cellulase) 		5 ILE A 288
ALA A  47
THR A  43
VAL A  84
ALA A  88
 None
 1.30A 4oqrA-1tvpA:
undetectable		 4oqrA-1tvpA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 VAL A 362
VAL A 534
ALA A 872
VAL A 371
ALA A 367
 None
 1.27A 4oqrA-1vbgA:
undetectable		 4oqrA-1vbgA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0l HOMOISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		5 ILE A  18
VAL A  17
ALA A  20
THR A 324
VAL A 301
 None
 1.29A 4oqrA-1x0lA:
undetectable		 4oqrA-1x0lA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 VAL A1051
VAL A1016
ALA A1017
VAL A1033
ALA A1055
 None
 1.15A 4oqrA-2bruA:
undetectable		 4oqrA-2bruA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buf ACETYLGLUTAMATE
KINASE

(Pseudomonas
aeruginosa) 		PF00696
(AA_kinase) 		5 VAL A 267
ILE A 243
VAL A 239
THR A 293
ALA A 270
 None
 1.18A 4oqrA-2bufA:
undetectable		 4oqrA-2bufA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 VAL A  98
ILE A 113
VAL A 116
THR A 157
ALA A 151
 None
 1.31A 4oqrA-2cfmA:
undetectable		 4oqrA-2cfmA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuk XC6422 PROTEIN

(Xanthomonas
campestris) 		PF12146
(Hydrolase_4) 		5 PRO A  29
VAL A  38
ALA A  25
VAL A  42
ALA A  40
 None
 1.25A 4oqrA-2fukA:
undetectable		 4oqrA-2fukA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqw FERREDOXIN REDUCTASE

(Pseudomonas sp.
KKS102) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 VAL A 274
ILE A 299
ALA A 302
VAL A  12
ALA A 108
 None
 1.11A 4oqrA-2gqwA:
undetectable		 4oqrA-2gqwA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gup ROK FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF00480
(ROK) 		5 VAL A 104
ILE A  70
VAL A  63
ALA A  62
ALA A 101
 SUC  A 290 (-4.7A)
None
None
None
None
 1.14A 4oqrA-2gupA:
undetectable		 4oqrA-2gupA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqi HYPOTHETICAL PROTEIN
XCC0632

(Xanthomonas
campestris) 		PF03886
(ABC_trans_aux) 		5 VAL A 168
ILE A  70
VAL A 180
ALA A 181
ALA A 187
 None
 1.11A 4oqrA-2iqiA:
undetectable		 4oqrA-2iqiA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnj CYTOCHROME P450 2C8

(Homo sapiens) 		PF00067
(p450) 		5 VAL A  83
VAL A 370
ALA A 369
THR A 386
ALA A 389
 None
 1.18A 4oqrA-2nnjA:
30.9		 4oqrA-2nnjA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxo HYPOTHETICAL PROTEIN
SCO4506

(Streptomyces
coelicolor) 		PF02621
(VitK2_biosynth) 		5 VAL A  57
ILE A 201
VAL A 205
VAL A  70
ALA A 189
 None
 1.14A 4oqrA-2nxoA:
undetectable		 4oqrA-2nxoA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ILE A 438
VAL A 405
ALA A 404
VAL A 226
ALA A 223
 None
 1.09A 4oqrA-2qt6A:
undetectable		 4oqrA-2qt6A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		5 ILE A 191
ALA A 153
THR A 258
VAL A  83
ALA A 254
 None
 1.20A 4oqrA-2yheA:
undetectable		 4oqrA-2yheA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0j PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1438

(Thermus
thermophilus) 		PF04029
(2-ph_phosp) 		5 VAL A  22
VAL A 215
ALA A 216
VAL A 221
ALA A 116
 None
 1.32A 4oqrA-2z0jA:
undetectable		 4oqrA-2z0jA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		5 ILE A 139
VAL A 112
ALA A 113
THR A  98
VAL A 133
 None
 1.27A 4oqrA-3a4tA:
undetectable		 4oqrA-3a4tA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cai POSSIBLE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		5 PRO A 233
ALA A 210
THR A 208
VAL A  74
ALA A  76
 None
 1.27A 4oqrA-3caiA:
undetectable		 4oqrA-3caiA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqb PROBABLE PROTEASE
HTPX HOMOLOG

(Vibrio
parahaemolyticus) 		PF01435
(Peptidase_M48) 		5 VAL A  83
ILE A  14
VAL A  43
ALA A  44
ALA A  53
 None
 1.15A 4oqrA-3cqbA:
undetectable		 4oqrA-3cqbA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hqf RESTRICTION
ENDONUCLEASE

(Escherichia
coli) 		PF09217
(EcoRII-N) 		5 TRP A   9
ILE A  13
VAL A  20
ALA A 165
ALA A 151
 None
 1.23A 4oqrA-3hqfA:
undetectable		 4oqrA-3hqfA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PRO A 326
VAL A  16
VAL A 343
ALA A  35
ALA A   3
 None
 1.33A 4oqrA-3jv7A:
undetectable		 4oqrA-3jv7A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l06 N-ACETYLORNITHINE
CARBAMOYLTRANSFERASE

(Xanthomonas
campestris) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 PRO A  72
ILE A  95
VAL A  98
ALA A  99
ALA A  42
 None
 1.11A 4oqrA-3l06A:
undetectable		 4oqrA-3l06A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l06 N-ACETYLORNITHINE
CARBAMOYLTRANSFERASE

(Xanthomonas
campestris) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 PRO A  72
VAL A  69
ILE A  95
VAL A  98
ALA A  99
 None
 1.14A 4oqrA-3l06A:
undetectable		 4oqrA-3l06A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp9 LS-24

(Lathyrus
sativus) 		PF00045
(Hemopexin) 		5 VAL A 186
ILE A  77
ALA A  75
THR A  70
VAL A 132
 None
 1.31A 4oqrA-3lp9A:
undetectable		 4oqrA-3lp9A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1l 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 ILE A 225
ALA A 227
THR A 255
VAL A 240
ALA A 234
 None
None
None
None
ACT  A   1 (-3.9A)
 1.21A 4oqrA-3m1lA:
undetectable		 4oqrA-3m1lA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Yersinia pestis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 PRO A 355
VAL A 387
VAL A 377
THR A 379
VAL A 413
 None
None
None
None
BME  A 507 ( 4.5A)
 1.29A 4oqrA-3mjfA:
undetectable		 4oqrA-3mjfA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Roseobacter
denitrificans) 		PF01039
(Carboxyl_trans) 		5 VAL B 394
ILE B 409
ALA B 413
VAL B 440
ALA B 438
 None
 1.28A 4oqrA-3n6rB:
undetectable		 4oqrA-3n6rB:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqs TRANSFERRIN-BINDING
PROTEIN

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		5 VAL A 516
ILE A 350
ALA A 415
THR A 400
ALA A 518
 None
 1.24A 4oqrA-3pqsA:
undetectable		 4oqrA-3pqsA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s52 PUTATIVE
FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN

(Yersinia pestis) 		PF01557
(FAA_hydrolase) 		5 VAL A 195
ILE A 130
VAL A  98
ALA A  74
THR A 189
 None
 1.26A 4oqrA-3s52A:
undetectable		 4oqrA-3s52A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		5 PRO A 384
ILE A 380
VAL A 243
ALA A 237
THR A 240
 None
 1.33A 4oqrA-3upyA:
undetectable		 4oqrA-3upyA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vov GLUCOKINASE

(Thermus
thermophilus) 		PF00480
(ROK) 		5 VAL A  27
ILE A  90
VAL A  39
ALA A  40
ALA A  46
 None
 1.16A 4oqrA-3vovA:
undetectable		 4oqrA-3vovA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
SUBUNIT D
V-TYPE ATP SYNTHASE
SUBUNIT F

(Thermus
thermophilus) 		PF01813
(ATP-synt_D)
PF01990
(ATP-synt_F) 		5 VAL H  47
ILE G 138
VAL G 140
ALA G 141
THR G 145
 None
 1.32A 4oqrA-3w3aH:
undetectable		 4oqrA-3w3aH:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxm PROTEIN PELOTA
HOMOLOG

(Aeropyrum
pernix) 		PF03463
(eRF1_1)
PF03465
(eRF1_3) 		5 PRO B 330
VAL B 232
ALA B 145
THR B 128
ALA B 142
 None
 1.17A 4oqrA-3wxmB:
undetectable		 4oqrA-3wxmB:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgx CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis) 		PF02463
(SMC_N) 		5 VAL A1146
ILE A  18
VAL A1163
VAL A1159
ALA A  28
 None
 1.25A 4oqrA-3zgxA:
undetectable		 4oqrA-3zgxA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blp PACKAGING ENZYME P4

(Pseudomonas
phage phi13) 		PF11602
(NTPase_P4) 		5 PRO A  95
VAL A  90
VAL A 199
ALA A 200
ALA A 206
 None
 1.07A 4oqrA-4blpA:
undetectable		 4oqrA-4blpA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csw CUPIN 4 FAMILY
PROTEIN

(Rhodothermus
marinus) 		PF08007
(Cupin_4) 		5 PRO A 283
ILE A 280
ALA A 320
THR A 352
ALA A 315
 None
 1.18A 4oqrA-4cswA:
undetectable		 4oqrA-4cswA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1y PUTATIVE PROTEASE I

(Bacteroides
thetaiotaomicron) 		PF01965
(DJ-1_PfpI) 		5 VAL A  78
ILE A 122
THR A 156
VAL A 130
ALA A 112
 None
None
None
None
ZN  A1177 ( 4.4A)
 1.16A 4oqrA-4d1yA:
undetectable		 4oqrA-4d1yA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgq NON-HEME
CHLOROPEROXIDASE

(Burkholderia
cenocepacia) 		PF00561
(Abhydrolase_1) 		5 VAL A 115
ALA A  91
THR A  88
VAL A  82
ALA A  80
 None
 1.18A 4oqrA-4dgqA:
undetectable		 4oqrA-4dgqA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drt DE NOVO DESIGNED
SERINE HYDROLASE,
OR89

(synthetic
construct) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 VAL A  13
VAL A 240
ALA A 239
VAL A  31
ALA A  33
 None
 1.09A 4oqrA-4drtA:
undetectable		 4oqrA-4drtA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		5 ILE A 155
ALA A 151
THR A 137
VAL A 128
ALA A 112
 None
 1.27A 4oqrA-4evqA:
undetectable		 4oqrA-4evqA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Methanobrevibacter
ruminantium) 		PF02289
(MCH) 		5 VAL A  12
ILE A  82
ALA A  61
VAL A   4
ALA A   8
 None
 1.10A 4oqrA-4fioA:
undetectable		 4oqrA-4fioA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME

(Rickettsia
typhi) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 VAL A 572
ILE A 462
VAL A 545
ALA A 544
ALA A 575
 None
 1.29A 4oqrA-4hvtA:
undetectable		 4oqrA-4hvtA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ILE A 436
VAL A 405
ALA A 404
VAL A 225
ALA A 222
 None
 1.18A 4oqrA-4jhvA:
undetectable		 4oqrA-4jhvA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE

(Magnetospirillum
magneticum) 		PF00378
(ECH_1) 		5 VAL A 183
ILE A 150
VAL A 153
ALA A 154
ALA A 175
 None
 1.01A 4oqrA-4k2nA:
undetectable		 4oqrA-4k2nA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kiw 3-DEHYDROQUINATE
DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF01220
(DHquinase_II) 		5 TRP A  61
ILE A   8
ALA A  76
THR A  80
ALA A  85
 None
 1.31A 4oqrA-4kiwA:
undetectable		 4oqrA-4kiwA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 ILE A 233
VAL A 226
ALA A 225
VAL A  34
ALA A  31
 None
 1.22A 4oqrA-4kpgA:
undetectable		 4oqrA-4kpgA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Homo sapiens) 		PF01008
(IF-2B) 		5 ILE A 143
VAL A 184
ALA A 181
THR A 166
ALA A 242
 None
 1.31A 4oqrA-4ldqA:
undetectable		 4oqrA-4ldqA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Homo sapiens) 		PF01008
(IF-2B) 		5 VAL A 155
ILE A 143
ALA A 181
THR A 166
ALA A 242
 None
 1.14A 4oqrA-4ldqA:
undetectable		 4oqrA-4ldqA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfn GALACTOSE-6-PHOSPHAT
E ISOMERASE SUBUNIT
A
GALACTOSE-6-PHOSPHAT
E ISOMERASE SUBUNIT
B

(Lactobacillus
rhamnosus) 		PF02502
(LacAB_rpiB) 		5 VAL A  41
ILE A 102
VAL A  83
THR B  73
ALA A  72
 None
 1.28A 4oqrA-4lfnA:
undetectable		 4oqrA-4lfnA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 VAL A 947
ALA A 950
THR A 925
VAL A 989
ALA A 992
 None
 1.32A 4oqrA-4lnvA:
undetectable		 4oqrA-4lnvA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq8 SCA-FAMILY PROTEIN

(Rickettsia
rickettsii) 		PF12574
(120_Rick_ant) 		5 PRO A 299
VAL A 262
ILE A 164
ALA A 167
ALA A 276
 None
 1.28A 4oqrA-4lq8A:
undetectable		 4oqrA-4lq8A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi2 PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 VAL A  67
VAL A   9
ALA A   8
THR A  35
ALA A  31
 None
 1.33A 4oqrA-4mi2A:
undetectable		 4oqrA-4mi2A:
20.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oqs CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 VAL A 239
ALA A 240
THR A 244
VAL A 282
ALA A 388
 None
HEM  A 501 (-3.4A)
HEM  A 501 (-3.6A)
HEM  A 501 ( 4.8A)
None
 0.77A 4oqrA-4oqsA:
56.2		 4oqrA-4oqsA:
86.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2h PROLINE RACEMASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF05544
(Pro_racemase) 		5 VAL A 128
ILE A 109
THR A 117
VAL A 142
ALA A 130
 None
 1.20A 4oqrA-4q2hA:
undetectable		 4oqrA-4q2hA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 PRO A 288
ILE A 424
ALA A 427
VAL A 442
ALA A 452
 None
 1.31A 4oqrA-4q6rA:
undetectable		 4oqrA-4q6rA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlz SJCHGC07024 PROTEIN

(Schistosoma
japonicum) 		PF00719
(Pyrophosphatase) 		5 VAL A 158
ILE A 117
VAL A 119
ALA A  93
VAL A 132
 None
 1.31A 4oqrA-4qlzA:
undetectable		 4oqrA-4qlzA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcd BETA-SECRETASE 1

(Homo sapiens) 		PF00026
(Asp) 		5 VAL A  95
ILE A 118
VAL A  40
ALA A  39
ALA A  97
 None
3LL  A 501 (-4.6A)
None
None
None
 1.29A 4oqrA-4rcdA:
undetectable		 4oqrA-4rcdA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1

(Streptomyces
avermitilis) 		PF00698
(Acyl_transf_1) 		5 VAL A 224
VAL A 195
ALA A 187
THR A 280
ALA A 226
 None
 1.18A 4oqrA-4rl1A:
undetectable		 4oqrA-4rl1A:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rye D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		5 VAL A 192
ALA A 194
THR A 197
VAL A  73
ALA A  76
 None
 1.33A 4oqrA-4ryeA:
undetectable		 4oqrA-4ryeA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wva UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		PF01204
(Trehalase) 		5 TRP A 265
VAL A 253
ALA A 244
THR A 109
ALA A 250
 None
 1.28A 4oqrA-4wvaA:
undetectable		 4oqrA-4wvaA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah0 LIPASE

(Pelosinus
fermentans) 		no annotation 5 ILE A 171
VAL A 126
ALA A 127
VAL A  63
ALA A  61
 None
 1.04A 4oqrA-5ah0A:
undetectable		 4oqrA-5ah0A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahw UNIVERSAL STRESS
PROTEIN

(Mycolicibacterium
smegmatis) 		PF00582
(Usp) 		5 ILE A  36
VAL A   7
ALA A 108
THR A 139
VAL A 133
 None
 1.21A 4oqrA-5ahwA:
undetectable		 4oqrA-5ahwA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		5 PRO A 313
VAL A 174
ILE A 388
VAL A 376
ALA A 377
 None
 1.30A 4oqrA-5aqaA:
undetectable		 4oqrA-5aqaA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
aeruginosa) 		PF00275
(EPSP_synthase) 		5 VAL A 357
VAL A 243
ALA A 244
THR A 248
ALA A 318
 None
 1.08A 4oqrA-5bq2A:
undetectable		 4oqrA-5bq2A:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwo DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 5 VAL A  97
ILE A  49
VAL A  64
ALA A  65
ALA A  71
 None
 1.04A 4oqrA-5cwoA:
undetectable		 4oqrA-5cwoA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		5 VAL A  94
ALA A  92
THR A  88
VAL A  40
ALA A  82
 None
 1.25A 4oqrA-5e7pA:
undetectable		 4oqrA-5e7pA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h67 CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis) 		PF02463
(SMC_N) 		5 VAL B1146
ILE A  18
VAL B1163
VAL B1159
ALA A  28
 None
 1.25A 4oqrA-5h67B:
undetectable		 4oqrA-5h67B:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvc TYPE I MODULAR
POLYKETIDE SYNTHASE

(Mycobacterium
ulcerans) 		PF00550
(PP-binding) 		5 ILE A2083
VAL A2067
ALA A2070
THR A2105
ALA A2099
 None
 1.31A 4oqrA-5hvcA:
undetectable		 4oqrA-5hvcA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)

(Parageobacillus
thermoglucosidasius) 		PF00171
(Aldedh) 		5 VAL A 373
ILE A 406
VAL A 405
ALA A 408
ALA A 379
 None
 1.33A 4oqrA-5j78A:
undetectable		 4oqrA-5j78A:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002

(Bacteroides
thetaiotaomicron) 		no annotation 5 VAL A 458
ILE A 546
VAL A 524
ALA A 525
ALA A 467
 None
 1.24A 4oqrA-5mqpA:
undetectable		 4oqrA-5mqpA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(Methanotorris
formicicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 VAL B 348
ILE B  27
ALA B 248
VAL B 312
ALA B 308
 None
 1.26A 4oqrA-5n28B:
undetectable		 4oqrA-5n28B:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi) 		PF00883
(Peptidase_M17) 		5 VAL A 212
VAL A 227
ALA A 228
VAL A 318
ALA A 316
 None
 1.15A 4oqrA-5ntfA:
undetectable		 4oqrA-5ntfA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5j 30S RIBOSOMAL
PROTEIN S2

(Mycolicibacterium
smegmatis) 		PF00318
(Ribosomal_S2) 		5 VAL V  87
ILE V 207
ALA V 210
VAL V 216
ALA V 218
 None
 1.14A 4oqrA-5o5jV:
undetectable		 4oqrA-5o5jV:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvq SCABIN

(Streptomyces
scabiei) 		no annotation 5 VAL A 145
VAL A  49
ALA A  52
VAL A 116
ALA A 162
 None
 1.28A 4oqrA-5uvqA:
undetectable		 4oqrA-5uvqA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjc KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
pombe) 		no annotation 5 TRP A 210
VAL A 134
ILE A 225
VAL A 177
ALA A 176
 None
 1.08A 4oqrA-5wjcA:
undetectable		 4oqrA-5wjcA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xaz GAMMA-BUTYROLACTONE
RECEPTOR PROTEIN

(Streptomyces
fradiae) 		PF00440
(TetR_N) 		5 VAL A  15
ALA A  33
THR A  31
VAL A  21
ALA A  18
 None
 1.23A 4oqrA-5xazA:
undetectable		 4oqrA-5xazA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus) 		no annotation 5 TRP A 236
VAL A 243
ALA A 244
THR A 316
ALA A 329
 None
 1.19A 4oqrA-5xnzA:
undetectable		 4oqrA-5xnzA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6i -

(-) 		no annotation 5 VAL A 125
VAL A 230
ALA A 211
VAL A 226
ALA A 115
 None
 1.26A 4oqrA-5y6iA:
undetectable		 4oqrA-5y6iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c62 BIURET HYDROLASE

(Pseudomonas sp.
ADP) 		no annotation 5 PRO A 425
VAL A 184
ILE A 374
THR A 401
ALA A 179
 None
 1.23A 4oqrA-6c62A:
undetectable		 4oqrA-6c62A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwr -

(-) 		no annotation 5 VAL A 181
ALA A 178
THR A 176
VAL A 125
ALA A 128
 None
 1.33A 4oqrA-6cwrA:
undetectable		 4oqrA-6cwrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ej2 BETA-SECRETASE 1

(Homo sapiens) 		no annotation 5 VAL A 504
ILE A 527
VAL A 449
ALA A 448
ALA A 506
 None
B7E  A 901 (-4.4A)
None
None
None
 1.19A 4oqrA-6ej2A:
undetectable		 4oqrA-6ej2A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f71 GLUTATHIONE
TRANSFERASE

(Trametes
versicolor) 		no annotation 5 PRO A 170
VAL A  21
VAL A 228
ALA A  14
VAL A  57
 None
 1.23A 4oqrA-6f71A:
undetectable		 4oqrA-6f71A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ged PRGB

(Enterococcus
faecalis) 		no annotation 5 ILE A 295
VAL A 391
ALA A 390
VAL A 412
ALA A 542
 None
 1.26A 4oqrA-6gedA:
undetectable		 4oqrA-6gedA:
11.49