SIMILAR PATTERNS OF AMINO ACIDS FOR 4OLT_B_GCSB303

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a97 XANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF00156
(Pribosyltran) 		4 ILE A  33
ASP A  56
GLY A  79
HIS A  54
 None
 0.95A 4oltB-1a97A:
0.0		 4oltB-1a97A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT

(Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 ILE A 169
GLY A 111
VAL A 263
HIS A 509
 None
 1.07A 4oltB-1e6vA:
0.0		 4oltB-1e6vA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edg ENDOGLUCANASE A

([Clostridium]
cellulolyticum) 		PF00150
(Cellulase) 		4 ILE A 304
ARG A  79
GLY A  32
HIS A 254
 None
 1.05A 4oltB-1edgA:
0.0		 4oltB-1edgA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbz CATALASE

(Micrococcus
luteus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ILE A 476
ASP A 473
ARG A 435
VAL A 437
 None
 0.99A 4oltB-1hbzA:
0.0		 4oltB-1hbzA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyl HYPODERMA LINEATUM
COLLAGENASE

(Hypoderma
lineatum) 		PF00089
(Trypsin) 		4 ILE A  35
GLY A  44
VAL A 212
HIS A  57
 None
 0.86A 4oltB-1hylA:
0.0		 4oltB-1hylA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT
II

(Salmonella
enterica) 		PF00117
(GATase) 		4 ILE B 145
ARG B 157
GLY B 165
VAL B 163
 None
 1.09A 4oltB-1i1qB:
0.0		 4oltB-1i1qB:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1

(Homo sapiens) 		PF00415
(RCC1) 		4 ILE B 153
ASP B 148
GLY B 215
VAL B 207
 None
 1.05A 4oltB-1i2mB:
0.0		 4oltB-1i2mB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxn ANTI-H(O) LECTIN I

(Ulex europaeus) 		PF00139
(Lectin_legB) 		4 ILE A 129
GLY A 105
VAL A 150
HIS A 142
 None
MFU  A 501 (-3.1A)
None
MN  A 245 (-3.8A)
 0.92A 4oltB-1jxnA:
undetectable		 4oltB-1jxnA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		4 ILE A 284
ARG A 287
GLY A 147
VAL A 149
 None
 0.98A 4oltB-1l8wA:
0.0		 4oltB-1l8wA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 ILE A 661
ASP A 673
GLY A 604
HIS A 347
 None
 0.97A 4oltB-1lf9A:
undetectable		 4oltB-1lf9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF02548
(Pantoate_transf) 		4 ILE A 212
GLY A 203
VAL A 183
HIS A 136
 KPL  A 265 ( 4.0A)
None
None
KPL  A 265 (-4.5A)
 1.04A 4oltB-1m3uA:
undetectable		 4oltB-1m3uA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Ovis aries) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 ILE A 367
ASP A 193
GLY A 337
VAL A 277
 None
 1.05A 4oltB-1pgpA:
0.6		 4oltB-1pgpA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pwe L-SERINE DEHYDRATASE

(Rattus
norvegicus) 		PF00291
(PALP) 		4 ILE A 301
ASP A  32
ARG A  43
GLY A 175
 None
 1.05A 4oltB-1pweA:
undetectable		 4oltB-1pweA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgi PROTEIN
(CHITOSANASE)

(Bacillus
circulans) 		PF01374
(Glyco_hydro_46) 		4 ILE A  53
ASP A  55
ARG A  57
GLY A  65
 NAG  A 602 ( 4.7A)
None
GCS  A 600 (-3.7A)
GCS  A 601 ( 4.6A)
 0.55A 4oltB-1qgiA:
20.9		 4oltB-1qgiA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ASP A 557
ARG A 555
GLY A  80
VAL A  74
 None
 1.04A 4oltB-1qlbA:
undetectable		 4oltB-1qlbA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5v CITE

(Mycobacterium
tuberculosis) 		PF03328
(HpcH_HpaI) 		4 ILE A 166
ARG A 163
GLY A 135
VAL A 181
 None
 0.92A 4oltB-1u5vA:
undetectable		 4oltB-1u5vA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua7 ALPHA-AMYLASE

(Bacillus
subtilis) 		PF00128
(Alpha-amylase) 		4 ILE A 335
ASP A 332
ARG A 287
GLY A 289
 None
 1.00A 4oltB-1ua7A:
undetectable		 4oltB-1ua7A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxe FIBER PROTEIN

(Human
mastadenovirus
D) 		PF00541
(Adeno_knob) 		4 ILE A 224
GLY A 314
VAL A 350
HIS A 231
 None
None
None
ZN  A1366 ( 3.2A)
 1.01A 4oltB-1uxeA:
undetectable		 4oltB-1uxeA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb4 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 ASP A 196
ARG A 162
GLY A 142
VAL A 165
 None
 0.87A 4oltB-1vb4A:
undetectable		 4oltB-1vb4A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		4 ILE A  94
ARG A 160
GLY A 153
VAL A 164
 None
 0.93A 4oltB-1wpwA:
undetectable		 4oltB-1wpwA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aif RIBOSOMAL PROTEIN
L7A

(Cryptosporidium
parvum) 		PF01248
(Ribosomal_L7Ae) 		4 ILE A  28
ARG A  96
GLY A  95
VAL A 100
 None
 1.08A 4oltB-2aifA:
undetectable		 4oltB-2aifA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amx ADENOSINE DEAMINASE

(Plasmodium
yoelii) 		PF00962
(A_deaminase) 		4 ILE A 183
ASP A 211
GLY A 214
HIS A  55
 None
None
None
CO  A1000 (-3.3A)
 0.83A 4oltB-2amxA:
undetectable		 4oltB-2amxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azq CATECHOL
1,2-DIOXYGENASE

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 ILE A 191
ASP A 123
ARG A 121
VAL A 275
 None
 1.09A 4oltB-2azqA:
undetectable		 4oltB-2azqA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cic DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDE HYDROLASE

(Campylobacter
jejuni) 		PF08761
(dUTPase_2) 		4 ILE A  73
ASP A  77
VAL A 177
HIS A  80
 None
MG  A1970 ( 3.2A)
None
DUP  A1968 (-3.7A)
 0.97A 4oltB-2cicA:
undetectable		 4oltB-2cicA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyw CONSERVED
HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF01784
(NIF3) 		4 ILE A 134
ASP A 103
GLY A 185
HIS A  99
 None
 1.06A 4oltB-2fywA:
undetectable		 4oltB-2fywA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ASP A  80
ARG A 235
GLY A 237
HIS A 282
 None
MLT  A 503 ( 2.8A)
None
MLT  A 503 ( 3.9A)
 0.92A 4oltB-2g76A:
undetectable		 4oltB-2g76A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ILE A 294
ASP A 319
GLY A 187
VAL A 185
 None
 1.03A 4oltB-2i3aA:
undetectable		 4oltB-2i3aA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6v GENERAL SECRETION
PATHWAY PROTEIN C

(Vibrio cholerae) 		no annotation 4 ASP A 259
ARG A 294
GLY A 296
HIS A 299
 None
 1.09A 4oltB-2i6vA:
undetectable		 4oltB-2i6vA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		4 ASP A 319
ARG A 235
GLY A 236
VAL A 230
 None
 1.05A 4oltB-2i7tA:
undetectable		 4oltB-2i7tA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 ILE A 382
ARG A  16
GLY A 428
HIS A 296
 None
 1.00A 4oltB-2p2mA:
undetectable		 4oltB-2p2mA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1

(Saccharomyces
cerevisiae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 ILE A 367
ASP A 192
GLY A 337
VAL A 276
 None
 0.96A 4oltB-2p4qA:
undetectable		 4oltB-2p4qA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5i BH3822 PROTEIN

(Bacillus
halodurans) 		PF03099
(BPL_LplA_LipB) 		4 ILE A 103
ASP A 100
GLY A 187
HIS A  85
 None
 0.97A 4oltB-2p5iA:
undetectable		 4oltB-2p5iA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Bacillus
halodurans) 		PF01715
(IPPT) 		4 ARG A  91
GLY A  29
VAL A  58
HIS A  61
 None
 1.04A 4oltB-2qgnA:
undetectable		 4oltB-2qgnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq0 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 ASP A 196
ARG A 162
GLY A 142
VAL A 165
 None
 0.91A 4oltB-2vq0A:
undetectable		 4oltB-2vq0A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ILE A 380
ARG A 272
GLY A 275
VAL A 333
 None
 0.81A 4oltB-2wdwA:
undetectable		 4oltB-2wdwA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz4 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN LF

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 ILE A 120
GLY A 137
VAL A 153
HIS A 144
 None
 1.02A 4oltB-2xz4A:
undetectable		 4oltB-2xz4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ILE A 225
ASP A 390
ARG A 386
VAL A  47
 None
 0.90A 4oltB-2z1qA:
1.1		 4oltB-2z1qA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zau SELENIDE, WATER
DIKINASE

(Aquifex
aeolicus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ILE A  62
ASP A  60
GLY A 222
VAL A 220
 None
 1.08A 4oltB-2zauA:
undetectable		 4oltB-2zauA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayr ENDOGLUCANASE

(Piromyces
rhizinflatus) 		PF00150
(Cellulase) 		4 ILE A 275
ARG A  66
GLY A  16
HIS A 229
 None
 1.08A 4oltB-3ayrA:
undetectable		 4oltB-3ayrA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8c METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Vibrio cholerae) 		PF02743
(dCache_1) 		4 ILE A 253
GLY A 282
VAL A 284
HIS A 258
 None
 1.04A 4oltB-3c8cA:
undetectable		 4oltB-3c8cA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo4 UNCHARACTERIZED
PROTEIN MJ1062

(Methanocaldococcus
jannaschii) 		PF13302
(Acetyltransf_3) 		4 ILE A 374
ARG A 369
GLY A 417
VAL A 419
 None
MES  A   8 (-4.2A)
None
None
 0.96A 4oltB-3eo4A:
undetectable		 4oltB-3eo4A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewd ADENOSINE DEAMINASE

(Plasmodium
vivax) 		PF00962
(A_deaminase) 		4 ILE A 170
ASP A 197
GLY A 200
HIS A  42
 None
None
MCF  A 372 (-3.4A)
ZN  A 371 (-3.3A)
 0.90A 4oltB-3ewdA:
undetectable		 4oltB-3ewdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 ILE A 120
ASP A 422
GLY A 112
HIS A 396
 None
 1.07A 4oltB-3fefA:
undetectable		 4oltB-3fefA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		4 ILE A 280
GLY A 334
VAL A 298
HIS A 251
 None
 1.04A 4oltB-3g77A:
undetectable		 4oltB-3g77A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Nocardioides
aromaticivorans) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		4 ASP A 154
GLY A 377
VAL A 380
HIS A  36
 None
None
CL  A 395 ( 4.5A)
None
 1.07A 4oltB-3gcfA:
undetectable		 4oltB-3gcfA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3e UNCHARACTERIZED
PROTEIN TM1679

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		4 ILE A 205
ASP A 202
ARG A 229
GLY A 227
 None
 1.05A 4oltB-3h3eA:
undetectable		 4oltB-3h3eA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn8 SYNAPTOTAGMIN-3

(Rattus
norvegicus) 		PF00168
(C2) 		4 ASP A 541
GLY A 397
VAL A 399
HIS A 543
 None
None
None
ZN  A 700 (-3.1A)
 1.08A 4oltB-3hn8A:
undetectable		 4oltB-3hn8A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Enterococcus
faecalis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ILE A 288
ARG A  49
GLY A 163
VAL A  51
 None
CSO  A  22 ( 4.5A)
None
None
 1.05A 4oltB-3il4A:
undetectable		 4oltB-3il4A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Branchiostoma
belcheri) 		PF06172
(Cupin_5) 		4 ARG A 166
GLY A  63
VAL A 126
HIS A  88
 None
 0.98A 4oltB-3loiA:
undetectable		 4oltB-3loiA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n07 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Vibrio cholerae) 		PF08282
(Hydrolase_3) 		4 ARG A  54
GLY A  58
VAL A 163
HIS A  52
 None
 1.05A 4oltB-3n07A:
undetectable		 4oltB-3n07A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2n ANTHRAX TOXIN
RECEPTOR 1

(Homo sapiens) 		no annotation 4 ILE F 174
ASP F 193
ARG F 169
GLY F 172
 None
 1.04A 4oltB-3n2nF:
undetectable		 4oltB-3n2nF:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnm CURA

(Lyngbya
majuscula) 		PF05721
(PhyH) 		4 ILE A  61
ASP A  60
GLY A  56
VAL A 186
 None
FMT  A 755 (-4.2A)
None
None
 1.01A 4oltB-3nnmA:
undetectable		 4oltB-3nnmA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oms PHNB PROTEIN

(Bacillus cereus) 		PF06983
(3-dmu-9_3-mt) 		4 ILE A  92
ASP A  93
GLY A 110
HIS A  97
 None
None
EDO  A 501 ( 3.9A)
None
 0.84A 4oltB-3omsA:
undetectable		 4oltB-3omsA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owa ACYL-COA
DEHYDROGENASE

(Bacillus
anthracis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ILE A 227
ASP A 397
ARG A 393
VAL A  49
 None
 1.05A 4oltB-3owaA:
0.9		 4oltB-3owaA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE

(Actinobacillus
pleuropneumoniae) 		no annotation 4 ASP A 350
GLY A 300
VAL A 304
HIS A 272
 None
 0.98A 4oltB-3q3hA:
undetectable		 4oltB-3q3hA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcs RACEMASE, PUTATIVE

(Roseobacter
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 183
GLY A 234
VAL A 255
HIS A 207
 MG  A 368 ( 2.7A)
None
None
None
 1.08A 4oltB-3tcsA:
undetectable		 4oltB-3tcsA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 183
GLY A 234
VAL A 255
HIS A 207
 MG  A 371 ( 2.6A)
None
None
None
 1.09A 4oltB-3u4fA:
undetectable		 4oltB-3u4fA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpq GLUTATHIONE
S-TRANSFERASE SIGMA

(Bombyx mori) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A  88
ASP A  89
ARG A  69
GLY A  72
 None
 0.72A 4oltB-3vpqA:
undetectable		 4oltB-3vpqA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 ASP A 270
ARG A 342
GLY A 345
HIS A 467
 None
 1.03A 4oltB-3vu2A:
undetectable		 4oltB-3vu2A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bub UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--LD-LYSINE LIGASE

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ILE A 450
ASP A 471
ARG A 453
GLY A 372
 None
 1.07A 4oltB-4bubA:
undetectable		 4oltB-4bubA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 MGC81050 PROTEIN

(Xenopus laevis) 		PF00400
(WD40) 		4 ILE B 264
GLY B 307
VAL B 312
HIS B 315
 None
 0.91A 4oltB-4g56B:
undetectable		 4oltB-4g56B:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im4 ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		4 ILE A 313
ARG A 104
GLY A  67
HIS A 268
 None
 1.05A 4oltB-4im4A:
undetectable		 4oltB-4im4A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iws PA0254

(Pseudomonas
aeruginosa) 		PF01977
(UbiD) 		4 ILE A 429
GLY A 449
VAL A 435
HIS A 389
 None
 0.96A 4oltB-4iwsA:
undetectable		 4oltB-4iwsA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 ILE A 259
ASP A 260
GLY A 246
VAL A 132
 None
 0.92A 4oltB-4jwyA:
undetectable		 4oltB-4jwyA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE E 133
ARG E 228
VAL E 285
HIS E 291
 None
 0.97A 4oltB-4md8E:
undetectable		 4oltB-4md8E:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ILE A1241
ASP A1235
ARG A1239
GLY A  51
 None
 1.02A 4oltB-4o9xA:
undetectable		 4oltB-4o9xA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ILE A1241
ASP A1235
ARG A1239
GLY A  52
 None
 0.98A 4oltB-4o9xA:
undetectable		 4oltB-4o9xA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4our PHYTOCHROME B

(Arabidopsis
thaliana) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 ILE B 561
GLY B 300
VAL B 286
HIS B 279
 None
 0.98A 4oltB-4ourB:
undetectable		 4oltB-4ourB:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5r GLUTATHIONE
S-TRANSFERASE

(Blattella
germanica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A  89
ASP A  90
ARG A  70
GLY A  73
 None
 0.77A 4oltB-4q5rA:
1.0		 4oltB-4q5rA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ILE B 649
GLY B 460
VAL A 787
HIS A 790
 None
 1.07A 4oltB-4qiwB:
undetectable		 4oltB-4qiwB:
13.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qwp CHITOSANASE

(Pseudomonas sp.
A-01) 		PF01374
(Glyco_hydro_46) 		5 ILE A  41
ARG A  45
GLY A  53
VAL A 151
HIS A 203
 GCS  A 303 (-4.2A)
GCS  A 302 (-4.0A)
None
None
GCS  A 303 ( 4.9A)
 0.15A 4oltB-4qwpA:
42.7		 4oltB-4qwpA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN

(Sesbania mosaic
virus;
Staphylococcus
aureus) 		no annotation 4 ASP A 196
ARG A 162
GLY A 142
VAL A 165
 None
 0.98A 4oltB-4y5zA:
undetectable		 4oltB-4y5zA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avo HOMOSERINE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 ILE A  32
ASP A  45
ARG A  16
GLY A  12
 None
 1.03A 4oltB-5avoA:
undetectable		 4oltB-5avoA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 ASP A 286
ARG A 355
GLY A 358
HIS A 480
 None
 1.06A 4oltB-5clwA:
undetectable		 4oltB-5clwA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 ILE A 555
ASP A 559
ARG A 535
VAL A 494
 None
None
CL  A 908 (-4.0A)
None
 1.04A 4oltB-5dllA:
undetectable		 4oltB-5dllA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex6 CYTOCHROME P450

(Streptomyces
toyocaensis) 		no annotation 4 ILE C 140
ASP C 145
GLY C 390
VAL C 282
 None
 1.07A 4oltB-5ex6C:
undetectable		 4oltB-5ex6C:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5l GLUTATHIONE
S-TRANSFERASE S2

(Nilaparvata
lugens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A  88
ASP A  89
ARG A  69
GLY A  72
 None
 0.69A 4oltB-5h5lA:
0.9		 4oltB-5h5lA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hql RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ILE A 165
ASP A 194
GLY A 370
HIS A 288
 KCX  A 192 (-3.7A)
MG  A 501 ( 2.9A)
CAP  A 500 (-3.0A)
CAP  A 500 (-3.9A)
 0.87A 4oltB-5hqlA:
undetectable		 4oltB-5hqlA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 4 ILE A 280
ARG A 160
GLY A 398
HIS A 314
 None
GOL  A 654 (-4.0A)
None
None
 0.93A 4oltB-5jvkA:
undetectable		 4oltB-5jvkA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kay SPELTER

(unidentified) 		PF00669
(Flagellin_N) 		4 ILE A 159
ASP A 156
ARG A  69
GLY A  67
 None
 1.03A 4oltB-5kayA:
undetectable		 4oltB-5kayA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 ILE b 470
ARG b  66
GLY b 233
VAL b 474
 None
 1.06A 4oltB-5l9wb:
undetectable		 4oltB-5l9wb:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lk7 VP1

(Slow bee
paralysis virus) 		PF08762
(CRPV_capsid) 		4 ILE A 139
GLY A 203
VAL A 120
HIS A 123
 None
 0.74A 4oltB-5lk7A:
undetectable		 4oltB-5lk7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ILE A 165
ASP A 195
GLY A 400
HIS A 288
 CAP  A 501 (-3.7A)
MG  A 502 ( 3.0A)
CAP  A 501 (-3.0A)
CAP  A 501 (-3.8A)
 0.87A 4oltB-5macA:
undetectable		 4oltB-5macA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 133
ARG A 228
VAL A 285
HIS A 291
 None
 0.85A 4oltB-5movA:
undetectable		 4oltB-5movA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mxp -

(-) 		no annotation 4 ILE A  84
ASP A  81
ARG A  85
VAL A  18
 None
 1.08A 4oltB-5mxpA:
undetectable		 4oltB-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6c D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Homo sapiens) 		no annotation 4 ASP A  81
ARG A 236
GLY A 238
HIS A 283
 None
TLA  A 401 ( 2.7A)
None
TLA  A 401 ( 3.8A)
 1.00A 4oltB-5n6cA:
undetectable		 4oltB-5n6cA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 ASP A 651
ARG A 587
GLY A 322
VAL A 626
 None
 1.09A 4oltB-5n6uA:
undetectable		 4oltB-5n6uA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 4 ILE A 313
ASP A 227
GLY A  80
VAL A  78
 None
 0.84A 4oltB-5n7qA:
undetectable		 4oltB-5n7qA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacterium
smegmatis) 		PF01261
(AP_endonuc_2) 		4 ASP A 196
ARG A 164
GLY A 167
HIS A 195
 None
 0.90A 4oltB-5tnvA:
undetectable		 4oltB-5tnvA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3c CTP SYNTHASE

(Escherichia
coli) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 ILE A 463
GLY A 490
VAL A 498
HIS A 467
 None
 1.05A 4oltB-5u3cA:
undetectable		 4oltB-5u3cA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ILE A1483
ASP A1453
GLY A1331
HIS A1485
 None
 1.02A 4oltB-5ujaA:
undetectable		 4oltB-5ujaA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um8 GLYCOPROTEIN GP41

(Human
immunodeficiency
virus 1) 		PF00517
(GP41) 		4 ILE B 583
ARG B 579
GLY B 547
VAL B 549
 None
 1.03A 4oltB-5um8B:
undetectable		 4oltB-5um8B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Zymomonas
mobilis) 		no annotation 4 ILE A  37
ASP A  65
ARG A  38
GLY A  28
 None
 1.02A 4oltB-5utiA:
undetectable		 4oltB-5utiA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 ILE A 229
ARG A 226
GLY A 203
VAL A 244
 None
None
MG  A 402 ( 4.4A)
None
 1.09A 4oltB-5vxcA:
undetectable		 4oltB-5vxcA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 ILE A 229
ARG A 226
GLY A 204
VAL A 244
 None
 0.98A 4oltB-5vxcA:
undetectable		 4oltB-5vxcA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES

(Corynebacterium
glutamicum) 		PF01053
(Cys_Met_Meta_PP) 		4 ILE A 114
GLY A 103
VAL A 136
HIS A  99
 None
 0.84A 4oltB-5x5hA:
undetectable		 4oltB-5x5hA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xuy AUTOPHAGY-RELATED
PROTEIN 13

(Homo sapiens) 		no annotation 4 ILE A  17
ASP A  14
ARG A  10
GLY A 181
 None
 1.05A 4oltB-5xuyA:
undetectable		 4oltB-5xuyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Mus musculus) 		no annotation 4 ILE B 958
ARG B 953
GLY B1005
VAL B1008
 None
 0.90A 4oltB-6bcqB:
1.9		 4oltB-6bcqB:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 4 ILE C 556
ASP C 557
GLY C 593
VAL C 634
 None
 0.97A 4oltB-6en4C:
undetectable		 4oltB-6en4C:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ASP A 470
ARG A 492
GLY A 449
VAL A 444
 None
 1.05A 4oltB-6f8zA:
undetectable		 4oltB-6f8zA:
16.13