SIMILAR PATTERNS OF AMINO ACIDS FOR 4OLT_A_GCSA303

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a97 XANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF00156
(Pribosyltran) 		4 ILE A  33
ASP A  56
GLY A  79
HIS A  54
 None
 1.02A 4oltA-1a97A:
undetectable		 4oltA-1a97A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edg ENDOGLUCANASE A

([Clostridium]
cellulolyticum) 		PF00150
(Cellulase) 		4 ILE A 304
ARG A  79
GLY A  32
HIS A 254
 None
 1.07A 4oltA-1edgA:
0.0		 4oltA-1edgA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyl HYPODERMA LINEATUM
COLLAGENASE

(Hypoderma
lineatum) 		PF00089
(Trypsin) 		4 ILE A  35
GLY A  44
VAL A 212
HIS A  57
 None
 0.84A 4oltA-1hylA:
0.0		 4oltA-1hylA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1

(Homo sapiens) 		PF00415
(RCC1) 		4 ILE B 153
ASP B 148
GLY B 215
VAL B 207
 None
 1.08A 4oltA-1i2mB:
0.0		 4oltA-1i2mB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxn ANTI-H(O) LECTIN I

(Ulex europaeus) 		PF00139
(Lectin_legB) 		4 ILE A 129
GLY A 105
VAL A 150
HIS A 142
 None
MFU  A 501 (-3.1A)
None
MN  A 245 (-3.8A)
 0.90A 4oltA-1jxnA:
0.0		 4oltA-1jxnA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		4 ILE A 284
ARG A 287
GLY A 147
VAL A 149
 None
 1.02A 4oltA-1l8wA:
0.0		 4oltA-1l8wA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgf P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 ILE A 140
ASP A 145
GLY A 390
VAL A 282
 None
 1.05A 4oltA-1lgfA:
0.0		 4oltA-1lgfA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Ovis aries) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 ILE A 367
ASP A 193
GLY A 337
VAL A 277
 None
 1.01A 4oltA-1pgpA:
0.0		 4oltA-1pgpA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pwe L-SERINE DEHYDRATASE

(Rattus
norvegicus) 		PF00291
(PALP) 		4 ILE A 301
ASP A  32
ARG A  43
GLY A 175
 None
 1.07A 4oltA-1pweA:
0.0		 4oltA-1pweA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgi PROTEIN
(CHITOSANASE)

(Bacillus
circulans) 		PF01374
(Glyco_hydro_46) 		4 ILE A  53
ASP A  55
ARG A  57
GLY A  65
 NAG  A 602 ( 4.7A)
None
GCS  A 600 (-3.7A)
GCS  A 601 ( 4.6A)
 0.50A 4oltA-1qgiA:
21.0		 4oltA-1qgiA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)

(Ascophyllum
nodosum) 		no annotation 4 ILE A 246
GLY A 100
VAL A  91
HIS A  60
 None
 0.89A 4oltA-1qi9A:
undetectable		 4oltA-1qi9A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ASP A 557
ARG A 555
GLY A  80
VAL A  74
 None
 1.06A 4oltA-1qlbA:
undetectable		 4oltA-1qlbA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5v CITE

(Mycobacterium
tuberculosis) 		PF03328
(HpcH_HpaI) 		4 ILE A 166
ARG A 163
GLY A 135
VAL A 181
 None
 0.90A 4oltA-1u5vA:
undetectable		 4oltA-1u5vA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua7 ALPHA-AMYLASE

(Bacillus
subtilis) 		PF00128
(Alpha-amylase) 		4 ILE A 335
ASP A 332
ARG A 287
GLY A 289
 None
 0.98A 4oltA-1ua7A:
undetectable		 4oltA-1ua7A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxe FIBER PROTEIN

(Human
mastadenovirus
D) 		PF00541
(Adeno_knob) 		4 ILE A 224
GLY A 314
VAL A 350
HIS A 231
 None
None
None
ZN  A1366 ( 3.2A)
 1.05A 4oltA-1uxeA:
undetectable		 4oltA-1uxeA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb4 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 ASP A 196
ARG A 162
GLY A 142
VAL A 165
 None
 0.87A 4oltA-1vb4A:
undetectable		 4oltA-1vb4A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		4 ILE A  94
ARG A 160
GLY A 153
VAL A 164
 None
 0.89A 4oltA-1wpwA:
undetectable		 4oltA-1wpwA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amx ADENOSINE DEAMINASE

(Plasmodium
yoelii) 		PF00962
(A_deaminase) 		4 ILE A 183
ASP A 211
GLY A 214
HIS A  55
 None
None
None
CO  A1000 (-3.3A)
 0.84A 4oltA-2amxA:
undetectable		 4oltA-2amxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4x FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 3

(Salmonella
enterica) 		PF00669
(Flagellin_N) 		4 ILE A 208
ASP A 205
ARG A 118
GLY A 116
 None
 1.08A 4oltA-2d4xA:
undetectable		 4oltA-2d4xA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Sulfurisphaera
tokodaii) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ILE A 381
ASP A 375
GLY A 297
VAL A 315
 None
 1.08A 4oltA-2e0iA:
undetectable		 4oltA-2e0iA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyw CONSERVED
HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF01784
(NIF3) 		4 ILE A 134
ASP A 103
GLY A 185
HIS A  99
 None
 1.04A 4oltA-2fywA:
undetectable		 4oltA-2fywA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ASP A  80
ARG A 235
GLY A 237
HIS A 282
 None
MLT  A 503 ( 2.8A)
None
MLT  A 503 ( 3.9A)
 0.91A 4oltA-2g76A:
undetectable		 4oltA-2g76A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqw FERREDOXIN REDUCTASE

(Pseudomonas sp.
KKS102) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 ILE A 255
ASP A 241
ARG A 245
GLY A 248
 None
 0.96A 4oltA-2gqwA:
undetectable		 4oltA-2gqwA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1n OLIGOENDOPEPTIDASE F

(Geobacillus
stearothermophilus) 		PF01432
(Peptidase_M3) 		4 ILE A 452
ARG A 237
GLY A 424
HIS A 432
 None
 0.95A 4oltA-2h1nA:
undetectable		 4oltA-2h1nA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i44 SERINE-THREONINE
PHOSPHATASE 2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		4 ASP A 185
ARG A 166
GLY A 274
VAL A 278
 None
None
CA  A 401 ( 4.8A)
None
 0.94A 4oltA-2i44A:
undetectable		 4oltA-2i44A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		4 ASP A 319
ARG A 235
GLY A 236
VAL A 230
 None
 1.04A 4oltA-2i7tA:
undetectable		 4oltA-2i7tA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 ILE A 382
ARG A  16
GLY A 428
HIS A 296
 None
 0.92A 4oltA-2p2mA:
undetectable		 4oltA-2p2mA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1

(Saccharomyces
cerevisiae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 ILE A 367
ASP A 192
GLY A 337
VAL A 276
 None
 0.93A 4oltA-2p4qA:
undetectable		 4oltA-2p4qA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5i BH3822 PROTEIN

(Bacillus
halodurans) 		PF03099
(BPL_LplA_LipB) 		4 ILE A 103
ASP A 100
GLY A 187
HIS A  85
 None
 0.94A 4oltA-2p5iA:
1.4		 4oltA-2p5iA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Bacillus
halodurans) 		PF01715
(IPPT) 		4 ARG A  91
GLY A  29
VAL A  58
HIS A  61
 None
 1.07A 4oltA-2qgnA:
undetectable		 4oltA-2qgnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnu EXOSOME COMPLEX
EXONUCLEASE RRP44

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		4 ILE D 884
GLY D 587
VAL D 577
HIS D 871
 None
 1.07A 4oltA-2vnuD:
undetectable		 4oltA-2vnuD:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq0 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 ASP A 196
ARG A 162
GLY A 142
VAL A 165
 None
 0.90A 4oltA-2vq0A:
undetectable		 4oltA-2vq0A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ILE A 380
ARG A 272
GLY A 275
VAL A 333
 None
 0.84A 4oltA-2wdwA:
undetectable		 4oltA-2wdwA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we9 MOBA-RELATED PROTEIN

(Mycobacterium
tuberculosis) 		PF12804
(NTP_transf_3) 		4 ILE A 117
GLY A   8
VAL A  10
HIS A 137
 None
 1.04A 4oltA-2we9A:
undetectable		 4oltA-2we9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz4 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN LF

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 ILE A 120
GLY A 137
VAL A 153
HIS A 144
 None
 0.94A 4oltA-2xz4A:
undetectable		 4oltA-2xz4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ILE A 225
ASP A 390
ARG A 386
VAL A  47
 None
 0.91A 4oltA-2z1qA:
0.7		 4oltA-2z1qA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahm OLIGOPEPTIDASE

(Geobacillus sp.
MO-1) 		no annotation 4 ILE A 452
ARG A 237
GLY A 424
HIS A 432
 None
 1.02A 4oltA-3ahmA:
undetectable		 4oltA-3ahmA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8c METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Vibrio cholerae) 		PF02743
(dCache_1) 		4 ILE A 253
GLY A 282
VAL A 284
HIS A 258
 None
 1.06A 4oltA-3c8cA:
undetectable		 4oltA-3c8cA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo4 UNCHARACTERIZED
PROTEIN MJ1062

(Methanocaldococcus
jannaschii) 		PF13302
(Acetyltransf_3) 		4 ILE A 374
ARG A 369
GLY A 417
VAL A 419
 None
MES  A   8 (-4.2A)
None
None
 1.01A 4oltA-3eo4A:
undetectable		 4oltA-3eo4A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewd ADENOSINE DEAMINASE

(Plasmodium
vivax) 		PF00962
(A_deaminase) 		4 ILE A 170
ASP A 197
GLY A 200
HIS A  42
 None
None
MCF  A 372 (-3.4A)
ZN  A 371 (-3.3A)
 0.93A 4oltA-3ewdA:
undetectable		 4oltA-3ewdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		4 ILE A 280
GLY A 334
VAL A 298
HIS A 251
 None
 1.01A 4oltA-3g77A:
undetectable		 4oltA-3g77A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3e UNCHARACTERIZED
PROTEIN TM1679

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		4 ILE A 205
ASP A 202
ARG A 229
GLY A 227
 None
 1.06A 4oltA-3h3eA:
undetectable		 4oltA-3h3eA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Enterococcus
faecalis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ILE A 288
ARG A  49
GLY A 163
VAL A  51
 None
CSO  A  22 ( 4.5A)
None
None
 1.06A 4oltA-3il4A:
undetectable		 4oltA-3il4A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Branchiostoma
belcheri) 		PF06172
(Cupin_5) 		4 ARG A 166
GLY A  63
VAL A 126
HIS A  88
 None
 0.95A 4oltA-3loiA:
undetectable		 4oltA-3loiA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n07 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Vibrio cholerae) 		PF08282
(Hydrolase_3) 		4 ARG A  54
GLY A  58
VAL A 163
HIS A  52
 None
 1.05A 4oltA-3n07A:
undetectable		 4oltA-3n07A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2n ANTHRAX TOXIN
RECEPTOR 1

(Homo sapiens) 		no annotation 4 ILE F 174
ASP F 193
ARG F 169
GLY F 172
 None
 1.03A 4oltA-3n2nF:
1.2		 4oltA-3n2nF:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnm CURA

(Lyngbya
majuscula) 		PF05721
(PhyH) 		4 ILE A  61
ASP A  60
GLY A  56
VAL A 186
 None
FMT  A 755 (-4.2A)
None
None
 1.00A 4oltA-3nnmA:
undetectable		 4oltA-3nnmA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oms PHNB PROTEIN

(Bacillus cereus) 		PF06983
(3-dmu-9_3-mt) 		4 ILE A  92
ASP A  93
GLY A 110
HIS A  97
 None
None
EDO  A 501 ( 3.9A)
None
 0.83A 4oltA-3omsA:
undetectable		 4oltA-3omsA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owa ACYL-COA
DEHYDROGENASE

(Bacillus
anthracis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ILE A 227
ASP A 397
ARG A 393
VAL A  49
 None
 1.02A 4oltA-3owaA:
3.7		 4oltA-3owaA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE

(Actinobacillus
pleuropneumoniae) 		no annotation 4 ASP A 350
GLY A 300
VAL A 304
HIS A 272
 None
 1.00A 4oltA-3q3hA:
undetectable		 4oltA-3q3hA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sks PUTATIVE
OLIGOENDOPEPTIDASE F

(Bacillus
anthracis) 		no annotation 4 ILE A 452
ARG A 237
GLY A 424
HIS A 432
 None
 0.93A 4oltA-3sksA:
undetectable		 4oltA-3sksA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Roseovarius sp.
TM1035) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 205
GLY A 256
VAL A 277
HIS A 229
 None
 1.08A 4oltA-3t9pA:
undetectable		 4oltA-3t9pA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcs RACEMASE, PUTATIVE

(Roseobacter
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 183
GLY A 234
VAL A 255
HIS A 207
 MG  A 368 ( 2.7A)
None
None
None
 1.07A 4oltA-3tcsA:
undetectable		 4oltA-3tcsA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdq PILY2 PROTEIN

(Pseudomonas
aeruginosa) 		PF14481
(Fimbrial_PilY2) 		4 ILE A  42
ASP A  43
GLY A  67
HIS A  44
 None
 0.99A 4oltA-3tdqA:
undetectable		 4oltA-3tdqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 183
GLY A 234
VAL A 255
HIS A 207
 MG  A 371 ( 2.6A)
None
None
None
 1.08A 4oltA-3u4fA:
undetectable		 4oltA-3u4fA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpq GLUTATHIONE
S-TRANSFERASE SIGMA

(Bombyx mori) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A  88
ASP A  89
ARG A  69
GLY A  72
 None
 0.68A 4oltA-3vpqA:
undetectable		 4oltA-3vpqA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 ASP A 270
ARG A 342
GLY A 345
HIS A 467
 None
 1.04A 4oltA-3vu2A:
undetectable		 4oltA-3vu2A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bub UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--LD-LYSINE LIGASE

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ILE A 450
ASP A 471
ARG A 453
GLY A 372
 None
 1.07A 4oltA-4bubA:
undetectable		 4oltA-4bubA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2

(Streptococcus
pneumoniae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ILE A 190
ASP A 187
GLY A 205
HIS A 451
 None
 0.99A 4oltA-4cu8A:
undetectable		 4oltA-4cu8A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		4 ILE A 770
ASP A 769
ARG A 771
GLY A 857
 None
 1.04A 4oltA-4ifqA:
undetectable		 4oltA-4ifqA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iws PA0254

(Pseudomonas
aeruginosa) 		PF01977
(UbiD) 		4 ILE A 429
GLY A 449
VAL A 435
HIS A 389
 None
 0.98A 4oltA-4iwsA:
undetectable		 4oltA-4iwsA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 ILE A 259
ASP A 260
GLY A 246
VAL A 132
 None
 0.93A 4oltA-4jwyA:
undetectable		 4oltA-4jwyA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lt6 POLY(A) POLYMERASE
GAMMA

(Homo sapiens) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		4 ASP A 207
ARG A 103
GLY A 100
VAL A 106
 None
None
3AT  A 601 (-3.5A)
None
 1.08A 4oltA-4lt6A:
0.6		 4oltA-4lt6A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE E 133
ARG E 228
VAL E 285
HIS E 291
 None
 1.02A 4oltA-4md8E:
undetectable		 4oltA-4md8E:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ILE A1241
ASP A1235
ARG A1239
GLY A  51
 None
 1.08A 4oltA-4o9xA:
undetectable		 4oltA-4o9xA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ILE A1241
ASP A1235
ARG A1239
GLY A  52
 None
 1.02A 4oltA-4o9xA:
undetectable		 4oltA-4o9xA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5r GLUTATHIONE
S-TRANSFERASE

(Blattella
germanica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A  89
ASP A  90
ARG A  70
GLY A  73
 None
 0.72A 4oltA-4q5rA:
undetectable		 4oltA-4q5rA:
23.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qwp CHITOSANASE

(Pseudomonas sp.
A-01) 		PF01374
(Glyco_hydro_46) 		5 ILE A  41
ARG A  45
GLY A  53
VAL A 151
HIS A 203
 GCS  A 303 (-4.2A)
GCS  A 302 (-4.0A)
None
None
GCS  A 303 ( 4.9A)
 0.21A 4oltA-4qwpA:
41.9		 4oltA-4qwpA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN

(Sesbania mosaic
virus;
Staphylococcus
aureus) 		no annotation 4 ASP A 196
ARG A 162
GLY A 142
VAL A 165
 None
 1.03A 4oltA-4y5zA:
undetectable		 4oltA-4y5zA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avo HOMOSERINE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 ILE A  32
ASP A  45
ARG A  16
GLY A  12
 None
 1.00A 4oltA-5avoA:
undetectable		 4oltA-5avoA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 ASP A 286
ARG A 355
GLY A 358
HIS A 480
 None
 1.07A 4oltA-5clwA:
undetectable		 4oltA-5clwA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 ILE A 555
ASP A 559
ARG A 535
VAL A 494
 None
None
CL  A 908 (-4.0A)
None
 1.05A 4oltA-5dllA:
undetectable		 4oltA-5dllA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex6 CYTOCHROME P450

(Streptomyces
toyocaensis) 		no annotation 4 ILE C 140
ASP C 145
GLY C 390
VAL C 282
 None
 1.03A 4oltA-5ex6C:
undetectable		 4oltA-5ex6C:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5l GLUTATHIONE
S-TRANSFERASE S2

(Nilaparvata
lugens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A  88
ASP A  89
ARG A  69
GLY A  72
 None
 0.65A 4oltA-5h5lA:
undetectable		 4oltA-5h5lA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hql RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ILE A 165
ASP A 194
GLY A 370
HIS A 288
 KCX  A 192 (-3.7A)
MG  A 501 ( 2.9A)
CAP  A 500 (-3.0A)
CAP  A 500 (-3.9A)
 0.88A 4oltA-5hqlA:
undetectable		 4oltA-5hqlA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 4 ILE A 280
ARG A 160
GLY A 398
HIS A 314
 None
GOL  A 654 (-4.0A)
None
None
 0.90A 4oltA-5jvkA:
undetectable		 4oltA-5jvkA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kay SPELTER

(unidentified) 		PF00669
(Flagellin_N) 		4 ILE A 159
ASP A 156
ARG A  69
GLY A  67
 None
 1.00A 4oltA-5kayA:
undetectable		 4oltA-5kayA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lk7 VP1

(Slow bee
paralysis virus) 		PF08762
(CRPV_capsid) 		4 ILE A 139
GLY A 203
VAL A 120
HIS A 123
 None
 0.76A 4oltA-5lk7A:
undetectable		 4oltA-5lk7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ILE A 165
ASP A 195
GLY A 400
HIS A 288
 CAP  A 501 (-3.7A)
MG  A 502 ( 3.0A)
CAP  A 501 (-3.0A)
CAP  A 501 (-3.8A)
 0.87A 4oltA-5macA:
undetectable		 4oltA-5macA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 133
ARG A 228
VAL A 285
HIS A 291
 None
 0.90A 4oltA-5movA:
undetectable		 4oltA-5movA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 4 ILE A 365
ASP A 362
ARG A 364
VAL A 299
 None
 1.07A 4oltA-5muxA:
undetectable		 4oltA-5muxA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mxp -

(-) 		no annotation 4 ILE A  84
ASP A  81
ARG A  85
VAL A  18
 None
 1.07A 4oltA-5mxpA:
undetectable		 4oltA-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6c D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Homo sapiens) 		no annotation 4 ASP A  81
ARG A 236
GLY A 238
HIS A 283
 None
TLA  A 401 ( 2.7A)
None
TLA  A 401 ( 3.8A)
 0.98A 4oltA-5n6cA:
undetectable		 4oltA-5n6cA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 ASP A 651
ARG A 587
GLY A 322
VAL A 626
 None
 1.08A 4oltA-5n6uA:
undetectable		 4oltA-5n6uA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 4 ILE A 313
ASP A 227
GLY A  80
VAL A  78
 None
 0.84A 4oltA-5n7qA:
undetectable		 4oltA-5n7qA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE

(Chlorella
variabilis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ILE A 567
ASP A 564
ARG A 528
GLY A 530
 None
 1.07A 4oltA-5nccA:
undetectable		 4oltA-5nccA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN

(Homo sapiens) 		PF00400
(WD40) 		4 ILE A  41
ASP A  66
GLY A  32
HIS A  65
 None
 1.00A 4oltA-5tf2A:
undetectable		 4oltA-5tf2A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacterium
smegmatis) 		PF01261
(AP_endonuc_2) 		4 ASP A 196
ARG A 164
GLY A 167
HIS A 195
 None
 0.90A 4oltA-5tnvA:
undetectable		 4oltA-5tnvA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3c CTP SYNTHASE

(Escherichia
coli) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 ILE A 463
GLY A 490
VAL A 498
HIS A 467
 None
 1.03A 4oltA-5u3cA:
undetectable		 4oltA-5u3cA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um8 GLYCOPROTEIN GP41

(Human
immunodeficiency
virus 1) 		PF00517
(GP41) 		4 ILE B 583
ARG B 579
GLY B 547
VAL B 549
 None
 1.07A 4oltA-5um8B:
undetectable		 4oltA-5um8B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Zymomonas
mobilis) 		no annotation 4 ILE A  37
ASP A  65
ARG A  38
GLY A  28
 None
 1.03A 4oltA-5utiA:
undetectable		 4oltA-5utiA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 ILE A 229
ARG A 226
GLY A 203
VAL A 244
 None
None
MG  A 402 ( 4.4A)
None
 1.01A 4oltA-5vxcA:
undetectable		 4oltA-5vxcA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 ILE A 229
ARG A 226
GLY A 204
VAL A 244
 None
 0.95A 4oltA-5vxcA:
undetectable		 4oltA-5vxcA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7l N,N'-DIACETYLBACILLI
OSAMINYL-1-PHOSPHATE
TRANSFERASE

(Campylobacter
concisus) 		no annotation 4 ILE A 172
ASP A 169
GLY A 135
VAL A 101
 None
 1.08A 4oltA-5w7lA:
undetectable		 4oltA-5w7lA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES

(Corynebacterium
glutamicum) 		PF01053
(Cys_Met_Meta_PP) 		4 ILE A 114
GLY A 103
VAL A 136
HIS A  99
 None
 0.77A 4oltA-5x5hA:
undetectable		 4oltA-5x5hA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xuy AUTOPHAGY-RELATED
PROTEIN 13

(Homo sapiens) 		no annotation 4 ILE A  17
ASP A  14
ARG A  10
GLY A 181
 None
 1.00A 4oltA-5xuyA:
undetectable		 4oltA-5xuyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 4 ILE A 120
ASP A 119
GLY A 112
VAL A  84
 None
 0.99A 4oltA-5yvsA:
1.6		 4oltA-5yvsA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 4 ILE C 556
ASP C 557
GLY C 593
VAL C 634
 None
 1.08A 4oltA-5zyaC:
undetectable		 4oltA-5zyaC:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 4 ILE C 556
ASP C 557
GLY C 593
VAL C 634
 None
 0.92A 4oltA-6en4C:
undetectable		 4oltA-6en4C:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ASP A 470
ARG A 492
GLY A 449
VAL A 444
 None
 1.07A 4oltA-6f8zA:
undetectable		 4oltA-6f8zA:
16.13