SIMILAR PATTERNS OF AMINO ACIDS FOR 4OLM_A_198A1001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drk D-RIBOSE-BINDING
PROTEIN

(Escherichia
coli) 		PF13407
(Peripla_BP_4) 		5 LEU A 198
LEU A 195
GLY A 196
LEU A 129
VAL A 212
 None
 1.33A 4olmA-1drkA:
undetectable		 4olmA-1drkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		5 LEU A 392
GLY A 433
LEU A 293
VAL A 362
ARG A 383
 None
 1.24A 4olmA-1ecgA:
undetectable		 4olmA-1ecgA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g2p ADENINE
PHOSPHORIBOSYLTRANSF
ERASE 1

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		5 LEU A 161
LEU A 164
GLY A 166
LEU A 170
THR A 176
 None
 1.19A 4olmA-1g2pA:
undetectable		 4olmA-1g2pA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtk PORPHOBILINOGEN
DEAMINASE

(Escherichia
coli) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		5 LEU A  95
GLY A  94
LEU A  70
VAL A  79
THR A 212
 None
 1.31A 4olmA-1gtkA:
undetectable		 4olmA-1gtkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		5 GLY A  11
LEU A 291
MET A 285
ARG A 218
THR A   8
 NAP  A1328 (-3.1A)
None
None
NAP  A1328 (-3.0A)
None
 1.41A 4olmA-1gveA:
undetectable		 4olmA-1gveA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg3 TRIOSEPHOSPHATE
ISOMERASE

(Pyrococcus
woesei) 		PF00121
(TIM)
PF05690
(ThiG) 		5 LEU A 180
LEU A 203
GLY A 182
VAL A 122
THR A 166
 None
3PP  A1226 ( 4.4A)
None
None
None
 1.37A 4olmA-1hg3A:
undetectable		 4olmA-1hg3A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5z SIPA

(Salmonella
enterica) 		PF09052
(SipA) 		5 LEU A 646
LEU A 642
LEU A 575
VAL A 548
MET A 602
 None
 1.27A 4olmA-1q5zA:
undetectable		 4olmA-1q5zA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 GLN B 113
LEU B  76
MET B  60
THR B  91
MET B  95
 None
 1.16A 4olmA-1skyB:
undetectable		 4olmA-1skyB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 XYLANASE INHIBITOR
PROTEIN I

(Triticum
aestivum) 		PF00704
(Glyco_hydro_18) 		5 LEU A  75
LEU A 120
GLY A 122
MET A  32
HIS A 185
 None
 1.30A 4olmA-1ta3A:
undetectable		 4olmA-1ta3A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		5 LEU A  22
GLY A  96
MET A 115
VAL A 113
THR A 226
 None
 1.16A 4olmA-1tqhA:
undetectable		 4olmA-1tqhA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887

(Thermus
thermophilus) 		PF03641
(Lysine_decarbox) 		5 LEU A   4
LEU A  36
GLY A  35
VAL A  28
MET A   1
 None
 1.00A 4olmA-1wehA:
undetectable		 4olmA-1wehA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 324
LEU A 327
MET A 362
VAL A 366
ARG A 372
 None
 0.68A 4olmA-1xb7A:
26.2		 4olmA-1xb7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xee CHEMOTAXIS-INHIBITIN
G PROTEIN CHIPS

(Staphylococcus
aureus) 		PF11434
(CHIPS) 		5 LEU A  38
LEU A  41
LEU A  76
MET A  62
VAL A  63
 None
 1.36A 4olmA-1xeeA:
undetectable		 4olmA-1xeeA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yya TRIOSEPHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00121
(TIM) 		5 LEU A 231
LEU A 208
GLY A 230
LEU A 245
VAL A  39
 None
 1.24A 4olmA-1yyaA:
undetectable		 4olmA-1yyaA:
24.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 704
LEU A 707
GLY A 708
GLN A 711
MET A 742
MET A 745
VAL A 746
ARG A 752
HIS A 874
THR A 877
MET A 895
 BHM  A   1 (-4.0A)
BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.6A)
BHM  A   1 (-3.8A)
None
BHM  A   1 (-3.0A)
None
 0.50A 4olmA-2ax9A:
40.0		 4olmA-2ax9A:
99.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cq1 PTB-LIKE PROTEIN L

(Homo sapiens) 		no annotation 5 LEU A  78
GLY A  79
LEU A 101
MET A 110
VAL A 111
 None
 1.29A 4olmA-2cq1A:
undetectable		 4olmA-2cq1A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		5 LEU A 186
LEU A 194
MET A 128
VAL A 125
HIS A 168
 None
 1.24A 4olmA-2cybA:
undetectable		 4olmA-2cybA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 LEU A 281
GLY A 280
VAL A 273
ARG A 363
THR A  95
 None
 1.07A 4olmA-2de2A:
undetectable		 4olmA-2de2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6g HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
baylyi) 		PF03466
(LysR_substrate) 		5 LEU A 147
GLY A 145
GLN A 131
LEU A 100
THR A 267
 None
 1.27A 4olmA-2f6gA:
undetectable		 4olmA-2f6gA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiq PUTATIVE TAGATOSE
6-PHOSPHATE KINASE 1

(Escherichia
coli) 		PF08013
(Tagatose_6_P_K) 		5 LEU A 123
LEU A  89
GLY A  90
MET A 103
MET A 127
 None
 1.04A 4olmA-2fiqA:
undetectable		 4olmA-2fiqA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ge3 PROBABLE
ACETYLTRANSFERASE

(Agrobacterium
tumefaciens) 		PF00583
(Acetyltransf_1) 		5 LEU A 124
LEU A  89
GLY A  90
LEU A  35
HIS A 127
 None
None
None
ACO  A1301 (-4.8A)
None
 1.30A 4olmA-2ge3A:
undetectable		 4olmA-2ge3A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7v TLL2115 PROTEIN

(Synechococcus
elongatus) 		PF13354
(Beta-lactamase2) 		5 LEU A 177
GLY A 180
LEU A 194
MET A 232
VAL A 233
 None
 1.36A 4olmA-2j7vA:
undetectable		 4olmA-2j7vA:
22.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  32
LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
 1CA  A 247 (-4.0A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.8A)
 0.47A 4olmA-2q3yA:
36.4		 4olmA-2q3yA:
59.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  35
GLN A  39
MET A  73
ARG A  80
MET A 222
 1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.8A)
None
 1.15A 4olmA-2q3yA:
36.4		 4olmA-2q3yA:
59.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkx BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 100
LEU A  97
GLY A  96
LEU A  12
VAL A 109
 None
 1.13A 4olmA-2qkxA:
undetectable		 4olmA-2qkxA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 PROTEIN TRANSPORT
PROTEIN SSS1
SEC SIXTY-ONE
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF00584
(SecE)
PF10559
(Plug_translocon) 		5 LEU A 464
GLY A 460
GLN A 264
VAL B  54
MET A 182
 None
 1.30A 4olmA-2ww9A:
undetectable		 4olmA-2ww9A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 464
LEU A 466
VAL A 429
ARG A 381
THR A 826
 None
 1.39A 4olmA-2y8nA:
undetectable		 4olmA-2y8nA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 LEU A 159
GLY A 158
GLN A 354
ARG A 405
THR A  78
 None
 1.34A 4olmA-3cmmA:
undetectable		 4olmA-3cmmA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE

(Histophilus
somni) 		PF00834
(Ribul_P_3_epim) 		5 LEU A 153
VAL A 150
ARG A 184
HIS A  43
MET A 195
 None
None
None
NI  A 238 (-3.3A)
None
 1.36A 4olmA-3cu2A:
undetectable		 4olmA-3cu2A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dj4 BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 100
LEU A  97
GLY A  96
LEU A  12
VAL A 109
 None
None
None
UD1  A4000 (-4.1A)
None
 1.16A 4olmA-3dj4A:
undetectable		 4olmA-3dj4A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 LEU A 176
GLY A 177
MET A 190
VAL A 192
ARG A 170
 None
 1.25A 4olmA-3gbrA:
undetectable		 4olmA-3gbrA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Sphingomonas
sp. KA1) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		5 LEU A  51
LEU A  52
GLY A  53
GLN A 378
ARG A  29
 None
 1.16A 4olmA-3gkqA:
undetectable		 4olmA-3gkqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 LEU A 142
MET A 357
VAL A 358
THR A 442
MET A 175
 None
 1.26A 4olmA-3hpaA:
undetectable		 4olmA-3hpaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 LEU A 103
GLY A 410
LEU A  32
HIS A 398
THR A 394
 None
 1.29A 4olmA-3k92A:
undetectable		 4olmA-3k92A:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 718
LEU A 721
GLY A 722
MET A 756
MET A 759
VAL A 760
ARG A 766
 WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
 0.45A 4olmA-3kbaA:
34.1		 4olmA-3kbaA:
54.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 718
LEU A 721
GLY A 722
MET A 756
VAL A 760
ARG A 766
MET A 909
 WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
None
 1.12A 4olmA-3kbaA:
34.1		 4olmA-3kbaA:
54.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 718
MET A 756
MET A 759
VAL A 760
HIS A 888
 WOW  A   1 (-4.2A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.1A)
None
 1.04A 4olmA-3kbaA:
34.1		 4olmA-3kbaA:
54.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 721
GLY A 722
GLN A 725
MET A 756
MET A 759
VAL A 760
ARG A 766
HIS A 888
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
None
 0.80A 4olmA-3kbaA:
34.1		 4olmA-3kbaA:
54.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 721
GLY A 722
MET A 756
VAL A 760
ARG A 766
HIS A 888
MET A 909
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
None
None
 1.21A 4olmA-3kbaA:
34.1		 4olmA-3kbaA:
54.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis) 		PF13649
(Methyltransf_25) 		5 LEU A 189
LEU A 260
GLY A 187
LEU A 133
VAL A 180
 None
 1.34A 4olmA-3kkzA:
undetectable		 4olmA-3kkzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 LEU A 220
GLN A 256
LEU A 304
MET A 309
THR A 268
 None
 1.14A 4olmA-3lk6A:
undetectable		 4olmA-3lk6A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m66 MTERF
DOMAIN-CONTAINING
PROTEIN 1,
MITOCHONDRIAL

(Homo sapiens) 		PF02536
(mTERF) 		5 LEU A 258
LEU A 287
MET A 243
VAL A 244
HIS A 231
 None
 1.39A 4olmA-3m66A:
undetectable		 4olmA-3m66A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB

(Thermus
thermophilus) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A 178
GLY A 183
LEU A 154
VAL A 157
HIS A 306
 None
 1.01A 4olmA-3oa0A:
undetectable		 4olmA-3oa0A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I

(Rhodobacter
sphaeroides) 		PF00115
(COX1) 		5 LEU A  39
LEU A  42
GLY A  41
THR A 150
MET A 106
 None
None
HEA  A   1 ( 4.1A)
None
HEA  A   1 (-3.8A)
 1.38A 4olmA-3omnA:
2.3		 4olmA-3omnA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ooq AMIDOHYDROLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		5 LEU A  94
GLY A 129
MET A 116
VAL A 115
HIS A  65
 None
 1.15A 4olmA-3ooqA:
undetectable		 4olmA-3ooqA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00342
(PGI) 		5 LEU A 427
GLY A 406
GLN A 410
LEU A 450
MET A 451
 None
 1.33A 4olmA-3qkiA:
undetectable		 4olmA-3qkiA:
17.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		7 LEU A  32
LEU A  35
GLY A  36
GLN A  39
MET A  70
MET A  73
ARG A  80
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
 0.56A 4olmA-3ry9A:
35.7		 4olmA-3ry9A:
54.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137

(Staphylococcus
aureus) 		PF13379
(NMT1_2) 		5 LEU A  82
LEU A  78
GLY A  40
LEU A  50
VAL A 222
 None
 1.34A 4olmA-3un6A:
undetectable		 4olmA-3un6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve9 OROTIDINE-5'-PHOSPHA
TE DECARBOXYLASE

(Metallosphaera
sedula) 		PF00215
(OMPdecase) 		5 LEU A 170
GLY A 167
GLN A 200
VAL A 179
THR A 137
 None
 1.39A 4olmA-3ve9A:
undetectable		 4olmA-3ve9A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix) 		PF00291
(PALP) 		5 LEU A 273
LEU A 253
GLY A 255
LEU A 349
VAL A 366
 None
 1.24A 4olmA-3vscA:
undetectable		 4olmA-3vscA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		5 LEU A 490
LEU A 493
GLY A 502
VAL A 467
HIS A 303
 None
 1.08A 4olmA-4aioA:
undetectable		 4olmA-4aioA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 421
LEU A 385
GLY A 386
GLN A 427
VAL A 302
 None
 1.20A 4olmA-4bjpA:
undetectable		 4olmA-4bjpA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bma UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Aspergillus
fumigatus) 		PF01704
(UDPGP) 		5 GLY A 251
GLN A 408
VAL A 413
HIS A 359
THR A 275
 None
 1.27A 4olmA-4bmaA:
undetectable		 4olmA-4bmaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwe GLYPICAN-1

(Homo sapiens) 		PF01153
(Glypican) 		5 LEU A 227
GLY A 226
LEU A 467
MET A 297
VAL A 298
 None
 1.39A 4olmA-4bweA:
undetectable		 4olmA-4bweA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 LEU A 631
GLY A 630
LEU A 653
VAL A 469
THR A 647
 None
 1.19A 4olmA-4c51A:
undetectable		 4olmA-4c51A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyv HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 GLY B  23
GLN B  34
MET B  17
VAL B  18
MET B 115
 None
 1.36A 4olmA-4cyvB:
undetectable		 4olmA-4cyvB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 LEU A 372
LEU A 374
GLY A 383
HIS A 463
MET A 385
 None
 1.40A 4olmA-4fgvA:
undetectable		 4olmA-4fgvA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixu ARGINASE-2,
MITOCHONDRIAL

(Homo sapiens) 		PF00491
(Arginase) 		5 LEU A  61
GLY A 324
GLN A 325
VAL A 318
ARG A  57
 None
 1.25A 4olmA-4ixuA:
undetectable		 4olmA-4ixuA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis) 		no annotation 5 LEU A 172
GLY A 171
LEU A 122
VAL A  83
THR A 128
 None
 1.34A 4olmA-4mfzA:
undetectable		 4olmA-4mfzA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 LEU A 398
GLY A 397
LEU A 363
MET A 465
VAL A 463
 None
 1.11A 4olmA-4n78A:
undetectable		 4olmA-4n78A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n81 INOSITOL
MONOPHOSPHATASE

(Zymomonas
mobilis) 		PF00459
(Inositol_P) 		5 LEU A 195
LEU A 192
GLY A 191
LEU A 214
THR A 135
 None
 1.39A 4olmA-4n81A:
undetectable		 4olmA-4n81A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2l GTP-BINDING PROTEIN
RHEB

(Mus musculus) 		PF00071
(Ras) 		5 LEU A  83
LEU A  12
GLY A  13
GLN A  64
VAL A  98
 None
 1.35A 4olmA-4o2lA:
undetectable		 4olmA-4o2lA:
19.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 563
LEU A 566
GLY A 567
GLN A 570
MET A 604
ARG A 611
 MOF  A 801 (-3.9A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-4.2A)
 0.86A 4olmA-4p6wA:
32.1		 4olmA-4p6wA:
50.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 566
GLY A 567
GLN A 570
MET A 601
MET A 604
ARG A 611
 MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.2A)
 0.94A 4olmA-4p6wA:
32.1		 4olmA-4p6wA:
50.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		5 LEU A 176
GLY A 216
GLN A 233
MET A 160
HIS A 241
 None
 1.37A 4olmA-4pdhA:
undetectable		 4olmA-4pdhA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxb UREIDOGLYCOLATE
HYDROLASE

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20) 		5 LEU A 466
LEU A 253
GLY A 462
LEU A 413
VAL A 270
 None
 1.37A 4olmA-4pxbA:
undetectable		 4olmA-4pxbA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU

(Pseudomonas
fluorescens) 		PF01734
(Patatin) 		5 LEU A 606
GLY A 608
LEU A 585
VAL A 590
THR A 628
 None
 0.94A 4olmA-4qmkA:
undetectable		 4olmA-4qmkA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		5 LEU A 471
LEU A 467
LEU A 180
VAL A 330
MET A 166
 None
 1.25A 4olmA-4r1zA:
2.0		 4olmA-4r1zA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7s TETRATRICOPEPTIDE
REPEAT PROTEIN

(Parabacteroides
merdae) 		PF13432
(TPR_16) 		5 LEU A  62
LEU A  65
GLY A  66
GLN A  69
LEU A 102
 None
 0.86A 4olmA-4r7sA:
undetectable		 4olmA-4r7sA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rot ESTERASE A

(Streptococcus
pyogenes) 		PF00756
(Esterase) 		5 LEU A  45
GLY A 121
LEU A 246
VAL A  72
THR A  59
 None
 1.21A 4olmA-4rotA:
undetectable		 4olmA-4rotA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		5 LEU A 232
LEU A 229
GLY A 230
LEU A 161
VAL A 246
 None
 1.22A 4olmA-4rs3A:
undetectable		 4olmA-4rs3A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		5 LEU A 232
LEU A 229
GLY A 230
LEU A 161
VAL A 246
 None
 1.21A 4olmA-4rsmA:
undetectable		 4olmA-4rsmA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru0 PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		5 LEU A 362
LEU A 359
GLY A 358
LEU A 350
VAL A 335
 None
 1.32A 4olmA-4ru0A:
undetectable		 4olmA-4ru0A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru0 PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		5 LEU A 383
LEU A 381
GLY A 391
LEU A 152
THR A 139
 None
 1.40A 4olmA-4ru0A:
undetectable		 4olmA-4ru0A:
19.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 769
LEU A 772
GLN A 776
MET A 807
ARG A 817
 CV7  A1987 (-4.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
 0.66A 4olmA-4udbA:
33.0		 4olmA-4udbA:
52.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Geobacillus
kaustophilus) 		PF01680
(SOR_SNZ) 		5 LEU A  93
LEU A  96
GLY A  97
MET A  71
VAL A  70
 None
 1.07A 4olmA-4wxzA:
undetectable		 4olmA-4wxzA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x22 TRIOSEPHOSPHATE
ISOMERASE

(Leptospira
interrogans) 		PF00121
(TIM) 		5 LEU A 236
LEU A 213
GLY A 235
LEU A 250
VAL A  42
 None
 1.33A 4olmA-4x22A:
undetectable		 4olmA-4x22A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyi KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
japonicus) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		5 LEU A 185
GLY A 184
VAL A 206
HIS A 260
THR A 249
 None
 1.13A 4olmA-4xyiA:
undetectable		 4olmA-4xyiA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjp MONOSACCHARIDE-TRANS
PORTING ATPASE

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		5 LEU A 221
LEU A 218
GLY A 219
LEU A 152
VAL A 234
 None
 1.37A 4olmA-4zjpA:
undetectable		 4olmA-4zjpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3c SIR2 FAMILY PROTEIN

(Streptococcus
pyogenes) 		no annotation 5 LEU A 142
GLY A 138
MET A 198
VAL A 199
HIS A 205
 None
 1.32A 4olmA-5a3cA:
undetectable		 4olmA-5a3cA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.00A 4olmA-5d6nA:
undetectable		 4olmA-5d6nA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eso 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Mycobacterium
tuberculosis) 		PF02776
(TPP_enzyme_N) 		5 LEU A 416
LEU A  65
GLY A  64
VAL A 408
THR A 434
 None
 1.40A 4olmA-5esoA:
undetectable		 4olmA-5esoA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 0.98A 4olmA-5ey8A:
undetectable		 4olmA-5ey8A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32

(Mycobacterium
marinum) 		PF00501
(AMP-binding) 		5 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.08A 4olmA-5ey9A:
undetectable		 4olmA-5ey9A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA

(Caldalkalibacillus
thermarum) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 GLN A 113
LEU A  76
MET A  60
THR A  91
MET A  95
 None
 1.31A 4olmA-5ik2A:
undetectable		 4olmA-5ik2A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		5 LEU A 638
GLY A 637
LEU A 660
VAL A 477
THR A 654
 None
 1.13A 4olmA-5kqiA:
undetectable		 4olmA-5kqiA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 769
LEU A 772
GLN A 776
MET A 807
ARG A 817
 ECV  A1101 (-4.7A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
 0.65A 4olmA-5mwpA:
36.1		 4olmA-5mwpA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Homo sapiens) 		PF00443
(UCH) 		5 LEU A 138
LEU A  70
GLY A  69
GLN A  84
THR A 133
 None
 1.33A 4olmA-5ohkA:
undetectable		 4olmA-5ohkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3)
PF14598
(PAS_11) 		5 LEU A 343
GLY A 174
LEU B 146
HIS B 289
THR B 274
 None
 1.12A 4olmA-5sy5A:
undetectable		 4olmA-5sy5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzb D-AMINOPEPTIDASE

(Burkholderia
sp. LK4) 		PF03576
(Peptidase_S58) 		5 LEU A 133
LEU A 132
GLY A 131
HIS A 140
THR A  45
 None
 1.13A 4olmA-5tzbA:
undetectable		 4olmA-5tzbA:
19.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 GLY A 563
GLN A 566
MET A 597
MET A 600
ARG A 607
 486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
None
486  A 801 (-3.5A)
 0.81A 4olmA-5uc1A:
22.2		 4olmA-5uc1A:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 559
LEU A 562
GLY A 563
GLN A 566
MET A 600
ARG A 607
 486  A 801 (-4.7A)
486  A 801 ( 4.8A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
None
486  A 801 (-3.5A)
 0.81A 4olmA-5uc1A:
22.2		 4olmA-5uc1A:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  32
LEU A  35
GLY A  36
GLN A  39
MET A  70
ARG A  80
 1TA  A 301 (-3.5A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
 0.71A 4olmA-5ufsA:
34.0		 4olmA-5ufsA:
54.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  35
GLY A  36
GLN A  39
MET A  73
ARG A  80
 1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
 0.87A 4olmA-5ufsA:
34.0		 4olmA-5ufsA:
54.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq8 TYPE II SECRETION
SYSTEM PROTEIN D

(Vibrio cholerae) 		PF00263
(Secretin)
PF03958
(Secretin_N) 		5 LEU A 225
LEU A 228
LEU A 172
MET A 180
VAL A 181
 None
 1.16A 4olmA-5wq8A:
undetectable		 4olmA-5wq8A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvr KLLA0C04147P

(Kluyveromyces
lactis) 		PF01237
(Oxysterol_BP) 		5 LEU A1016
LEU A1017
GLY A1018
VAL A1012
ARG A1046
 SO4  A1302 (-4.3A)
SO4  A1302 (-3.6A)
None
None
SO4  A1302 ( 4.3A)
 1.28A 4olmA-5wvrA:
undetectable		 4olmA-5wvrA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxi EARP

(Neisseria
meningitidis) 		no annotation 5 LEU A  31
LEU A  35
GLY A  36
VAL A   7
HIS A  67
 None
 1.28A 4olmA-5wxiA:
undetectable		 4olmA-5wxiA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03739
(YjgP_YjgQ) 		5 LEU G 285
LEU G 107
MET G 106
MET G 103
VAL G 102
 None
 1.38A 4olmA-5x5yG:
undetectable		 4olmA-5x5yG:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		5 LEU C1260
LEU C1264
GLN C1231
LEU C1291
THR C1253
 None
 1.33A 4olmA-5y3rC:
undetectable		 4olmA-5y3rC:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzg PROTEIN ZIP2
SPORULATION-SPECIFIC
PROTEIN 16

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B 654
GLY B 655
MET A 151
VAL A 149
THR B 689
 None
 1.35A 4olmA-6bzgB:
undetectable		 4olmA-6bzgB:
14.62