SIMILAR PATTERNS OF AMINO ACIDS FOR 4OLM_A_198A1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drk D-RIBOSE-BINDING
PROTEIN

(Escherichia
coli) 		PF13407
(Peripla_BP_4) 		5 LEU A 198
LEU A 195
GLY A 196
LEU A 129
VAL A 212
 None
 1.33A 4olmA-1drkA:
undetectable		 4olmA-1drkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		5 LEU A 392
GLY A 433
LEU A 293
VAL A 362
ARG A 383
 None
 1.24A 4olmA-1ecgA:
undetectable		 4olmA-1ecgA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g2p ADENINE
PHOSPHORIBOSYLTRANSF
ERASE 1

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		5 LEU A 161
LEU A 164
GLY A 166
LEU A 170
THR A 176
 None
 1.19A 4olmA-1g2pA:
undetectable		 4olmA-1g2pA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtk PORPHOBILINOGEN
DEAMINASE

(Escherichia
coli) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		5 LEU A  95
GLY A  94
LEU A  70
VAL A  79
THR A 212
 None
 1.31A 4olmA-1gtkA:
undetectable		 4olmA-1gtkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		5 GLY A  11
LEU A 291
MET A 285
ARG A 218
THR A   8
 NAP  A1328 (-3.1A)
None
None
NAP  A1328 (-3.0A)
None
 1.41A 4olmA-1gveA:
undetectable		 4olmA-1gveA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg3 TRIOSEPHOSPHATE
ISOMERASE

(Pyrococcus
woesei) 		PF00121
(TIM)
PF05690
(ThiG) 		5 LEU A 180
LEU A 203
GLY A 182
VAL A 122
THR A 166
 None
3PP  A1226 ( 4.4A)
None
None
None
 1.37A 4olmA-1hg3A:
undetectable		 4olmA-1hg3A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5z SIPA

(Salmonella
enterica) 		PF09052
(SipA) 		5 LEU A 646
LEU A 642
LEU A 575
VAL A 548
MET A 602
 None
 1.27A 4olmA-1q5zA:
undetectable		 4olmA-1q5zA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 GLN B 113
LEU B  76
MET B  60
THR B  91
MET B  95
 None
 1.16A 4olmA-1skyB:
undetectable		 4olmA-1skyB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 XYLANASE INHIBITOR
PROTEIN I

(Triticum
aestivum) 		PF00704
(Glyco_hydro_18) 		5 LEU A  75
LEU A 120
GLY A 122
MET A  32
HIS A 185
 None
 1.30A 4olmA-1ta3A:
undetectable		 4olmA-1ta3A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		5 LEU A  22
GLY A  96
MET A 115
VAL A 113
THR A 226
 None
 1.16A 4olmA-1tqhA:
undetectable		 4olmA-1tqhA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887

(Thermus
thermophilus) 		PF03641
(Lysine_decarbox) 		5 LEU A   4
LEU A  36
GLY A  35
VAL A  28
MET A   1
 None
 1.00A 4olmA-1wehA:
undetectable		 4olmA-1wehA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 324
LEU A 327
MET A 362
VAL A 366
ARG A 372
 None
 0.68A 4olmA-1xb7A:
26.2		 4olmA-1xb7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xee CHEMOTAXIS-INHIBITIN
G PROTEIN CHIPS

(Staphylococcus
aureus) 		PF11434
(CHIPS) 		5 LEU A  38
LEU A  41
LEU A  76
MET A  62
VAL A  63
 None
 1.36A 4olmA-1xeeA:
undetectable		 4olmA-1xeeA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yya TRIOSEPHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00121
(TIM) 		5 LEU A 231
LEU A 208
GLY A 230
LEU A 245
VAL A  39
 None
 1.24A 4olmA-1yyaA:
undetectable		 4olmA-1yyaA:
24.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 704
LEU A 707
GLY A 708
GLN A 711
MET A 742
MET A 745
VAL A 746
ARG A 752
HIS A 874
THR A 877
MET A 895
 BHM  A   1 (-4.0A)
BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.6A)
BHM  A   1 (-3.8A)
None
BHM  A   1 (-3.0A)
None
 0.50A 4olmA-2ax9A:
40.0		 4olmA-2ax9A:
99.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cq1 PTB-LIKE PROTEIN L

(Homo sapiens) 		no annotation 5 LEU A  78
GLY A  79
LEU A 101
MET A 110
VAL A 111
 None
 1.29A 4olmA-2cq1A:
undetectable		 4olmA-2cq1A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		5 LEU A 186
LEU A 194
MET A 128
VAL A 125
HIS A 168
 None
 1.24A 4olmA-2cybA:
undetectable		 4olmA-2cybA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 LEU A 281
GLY A 280
VAL A 273
ARG A 363
THR A  95
 None
 1.07A 4olmA-2de2A:
undetectable		 4olmA-2de2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6g HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
baylyi) 		PF03466
(LysR_substrate) 		5 LEU A 147
GLY A 145
GLN A 131
LEU A 100
THR A 267
 None
 1.27A 4olmA-2f6gA:
undetectable		 4olmA-2f6gA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiq PUTATIVE TAGATOSE
6-PHOSPHATE KINASE 1

(Escherichia
coli) 		PF08013
(Tagatose_6_P_K) 		5 LEU A 123
LEU A  89
GLY A  90
MET A 103
MET A 127
 None
 1.04A 4olmA-2fiqA:
undetectable		 4olmA-2fiqA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ge3 PROBABLE
ACETYLTRANSFERASE

(Agrobacterium
tumefaciens) 		PF00583
(Acetyltransf_1) 		5 LEU A 124
LEU A  89
GLY A  90
LEU A  35
HIS A 127
 None
None
None
ACO  A1301 (-4.8A)
None
 1.30A 4olmA-2ge3A:
undetectable		 4olmA-2ge3A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7v TLL2115 PROTEIN

(Synechococcus
elongatus) 		PF13354
(Beta-lactamase2) 		5 LEU A 177
GLY A 180
LEU A 194
MET A 232
VAL A 233
 None
 1.36A 4olmA-2j7vA:
undetectable		 4olmA-2j7vA:
22.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  32
LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
 1CA  A 247 (-4.0A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.8A)
 0.47A 4olmA-2q3yA:
36.4		 4olmA-2q3yA:
59.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  35
GLN A  39
MET A  73
ARG A  80
MET A 222
 1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.8A)
None
 1.15A 4olmA-2q3yA:
36.4		 4olmA-2q3yA:
59.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkx BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 100
LEU A  97
GLY A  96
LEU A  12
VAL A 109
 None
 1.13A 4olmA-2qkxA:
undetectable		 4olmA-2qkxA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 PROTEIN TRANSPORT
PROTEIN SSS1
SEC SIXTY-ONE
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF00584
(SecE)
PF10559
(Plug_translocon) 		5 LEU A 464
GLY A 460
GLN A 264
VAL B  54
MET A 182
 None
 1.30A 4olmA-2ww9A:
undetectable		 4olmA-2ww9A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 464
LEU A 466
VAL A 429
ARG A 381
THR A 826
 None
 1.39A 4olmA-2y8nA:
undetectable		 4olmA-2y8nA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 LEU A 159
GLY A 158
GLN A 354
ARG A 405
THR A  78
 None
 1.34A 4olmA-3cmmA:
undetectable		 4olmA-3cmmA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE

(Histophilus
somni) 		PF00834
(Ribul_P_3_epim) 		5 LEU A 153
VAL A 150
ARG A 184
HIS A  43
MET A 195
 None
None
None
NI  A 238 (-3.3A)
None
 1.36A 4olmA-3cu2A:
undetectable		 4olmA-3cu2A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dj4 BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 100
LEU A  97
GLY A  96
LEU A  12
VAL A 109
 None
None
None
UD1  A4000 (-4.1A)
None
 1.16A 4olmA-3dj4A:
undetectable		 4olmA-3dj4A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 LEU A 176
GLY A 177
MET A 190
VAL A 192
ARG A 170
 None
 1.25A 4olmA-3gbrA:
undetectable		 4olmA-3gbrA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Sphingomonas
sp. KA1) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		5 LEU A  51
LEU A  52
GLY A  53
GLN A 378
ARG A  29
 None
 1.16A 4olmA-3gkqA:
undetectable		 4olmA-3gkqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 LEU A 142
MET A 357
VAL A 358
THR A 442
MET A 175
 None
 1.26A 4olmA-3hpaA:
undetectable		 4olmA-3hpaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 LEU A 103
GLY A 410
LEU A  32
HIS A 398
THR A 394
 None
 1.29A 4olmA-3k92A:
undetectable		 4olmA-3k92A:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 718
LEU A 721
GLY A 722
MET A 756
MET A 759
VAL A 760
ARG A 766
 WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
 0.45A 4olmA-3kbaA:
34.1		 4olmA-3kbaA:
54.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 718
LEU A 721
GLY A 722
MET A 756
VAL A 760
ARG A 766
MET A 909
 WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
None
 1.12A 4olmA-3kbaA:
34.1		 4olmA-3kbaA:
54.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 718
MET A 756
MET A 759
VAL A 760
HIS A 888
 WOW  A   1 (-4.2A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.1A)
None
 1.04A 4olmA-3kbaA:
34.1		 4olmA-3kbaA:
54.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 721
GLY A 722
GLN A 725
MET A 756
MET A 759
VAL A 760
ARG A 766
HIS A 888
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
None
 0.80A 4olmA-3kbaA:
34.1		 4olmA-3kbaA:
54.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 721
GLY A 722
MET A 756
VAL A 760
ARG A 766
HIS A 888
MET A 909
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
None
None
 1.21A 4olmA-3kbaA:
34.1		 4olmA-3kbaA:
54.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis) 		PF13649
(Methyltransf_25) 		5 LEU A 189
LEU A 260
GLY A 187
LEU A 133
VAL A 180
 None
 1.34A 4olmA-3kkzA:
undetectable		 4olmA-3kkzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 LEU A 220
GLN A 256
LEU A 304
MET A 309
THR A 268
 None
 1.14A 4olmA-3lk6A:
undetectable		 4olmA-3lk6A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m66 MTERF
DOMAIN-CONTAINING
PROTEIN 1,
MITOCHONDRIAL

(Homo sapiens) 		PF02536
(mTERF) 		5 LEU A 258
LEU A 287
MET A 243
VAL A 244
HIS A 231
 None
 1.39A 4olmA-3m66A:
undetectable		 4olmA-3m66A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB

(Thermus
thermophilus) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A 178
GLY A 183
LEU A 154
VAL A 157
HIS A 306
 None
 1.01A 4olmA-3oa0A:
undetectable		 4olmA-3oa0A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I

(Rhodobacter
sphaeroides) 		PF00115
(COX1) 		5 LEU A  39
LEU A  42
GLY A  41
THR A 150
MET A 106
 None
None
HEA  A   1 ( 4.1A)
None
HEA  A   1 (-3.8A)
 1.38A 4olmA-3omnA:
2.3		 4olmA-3omnA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ooq AMIDOHYDROLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		5 LEU A  94
GLY A 129
MET A 116
VAL A 115
HIS A  65
 None
 1.15A 4olmA-3ooqA:
undetectable		 4olmA-3ooqA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00342
(PGI) 		5 LEU A 427
GLY A 406
GLN A 410
LEU A 450
MET A 451
 None
 1.33A 4olmA-3qkiA:
undetectable		 4olmA-3qkiA:
17.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		7 LEU A  32
LEU A  35
GLY A  36
GLN A  39
MET A  70
MET A  73
ARG A  80
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
 0.56A 4olmA-3ry9A:
35.7		 4olmA-3ry9A:
54.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137

(Staphylococcus
aureus) 		PF13379
(NMT1_2) 		5 LEU A  82
LEU A  78
GLY A  40
LEU A  50
VAL A 222
 None
 1.34A 4olmA-3un6A:
undetectable		 4olmA-3un6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve9 OROTIDINE-5'-PHOSPHA
TE DECARBOXYLASE

(Metallosphaera
sedula) 		PF00215
(OMPdecase) 		5 LEU A 170
GLY A 167
GLN A 200
VAL A 179
THR A 137
 None
 1.39A 4olmA-3ve9A:
undetectable		 4olmA-3ve9A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix) 		PF00291
(PALP) 		5 LEU A 273
LEU A 253
GLY A 255
LEU A 349
VAL A 366
 None
 1.24A 4olmA-3vscA:
undetectable		 4olmA-3vscA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		5 LEU A 490
LEU A 493
GLY A 502
VAL A 467
HIS A 303
 None
 1.08A 4olmA-4aioA:
undetectable		 4olmA-4aioA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 421
LEU A 385
GLY A 386
GLN A 427
VAL A 302
 None
 1.20A 4olmA-4bjpA:
undetectable		 4olmA-4bjpA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bma UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Aspergillus
fumigatus) 		PF01704
(UDPGP) 		5 GLY A 251
GLN A 408
VAL A 413
HIS A 359
THR A 275
 None
 1.27A 4olmA-4bmaA:
undetectable		 4olmA-4bmaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwe GLYPICAN-1

(Homo sapiens) 		PF01153
(Glypican) 		5 LEU A 227
GLY A 226
LEU A 467
MET A 297
VAL A 298
 None
 1.39A 4olmA-4bweA:
undetectable		 4olmA-4bweA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 LEU A 631
GLY A 630
LEU A 653
VAL A 469
THR A 647
 None
 1.19A 4olmA-4c51A:
undetectable		 4olmA-4c51A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyv HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 GLY B  23
GLN B  34
MET B  17
VAL B  18
MET B 115
 None
 1.36A 4olmA-4cyvB:
undetectable		 4olmA-4cyvB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 LEU A 372
LEU A 374
GLY A 383
HIS A 463
MET A 385
 None
 1.40A 4olmA-4fgvA:
undetectable		 4olmA-4fgvA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixu ARGINASE-2,
MITOCHONDRIAL

(Homo sapiens) 		PF00491
(Arginase) 		5 LEU A  61
GLY A 324
GLN A 325
VAL A 318
ARG A  57
 None
 1.25A 4olmA-4ixuA:
undetectable		 4olmA-4ixuA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis) 		no annotation 5 LEU A 172
GLY A 171
LEU A 122
VAL A  83
THR A 128
 None
 1.34A 4olmA-4mfzA:
undetectable		 4olmA-4mfzA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 LEU A 398
GLY A 397
LEU A 363
MET A 465
VAL A 463
 None
 1.11A 4olmA-4n78A:
undetectable		 4olmA-4n78A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n81 INOSITOL
MONOPHOSPHATASE

(Zymomonas
mobilis) 		PF00459
(Inositol_P) 		5 LEU A 195
LEU A 192
GLY A 191
LEU A 214
THR A 135
 None
 1.39A 4olmA-4n81A:
undetectable		 4olmA-4n81A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2l GTP-BINDING PROTEIN
RHEB

(Mus musculus) 		PF00071
(Ras) 		5 LEU A  83
LEU A  12
GLY A  13
GLN A  64
VAL A  98
 None
 1.35A 4olmA-4o2lA:
undetectable		 4olmA-4o2lA:
19.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 563
LEU A 566
GLY A 567
GLN A 570
MET A 604
ARG A 611
 MOF  A 801 (-3.9A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-4.2A)
 0.86A 4olmA-4p6wA:
32.1		 4olmA-4p6wA:
50.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 566
GLY A 567
GLN A 570
MET A 601
MET A 604
ARG A 611
 MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.2A)
 0.94A 4olmA-4p6wA:
32.1		 4olmA-4p6wA:
50.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		5 LEU A 176
GLY A 216
GLN A 233
MET A 160
HIS A 241
 None
 1.37A 4olmA-4pdhA:
undetectable		 4olmA-4pdhA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxb UREIDOGLYCOLATE
HYDROLASE

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20) 		5 LEU A 466
LEU A 253
GLY A 462
LEU A 413
VAL A 270
 None
 1.37A 4olmA-4pxbA:
undetectable		 4olmA-4pxbA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU

(Pseudomonas
fluorescens) 		PF01734
(Patatin) 		5 LEU A 606
GLY A 608
LEU A 585
VAL A 590
THR A 628
 None
 0.94A 4olmA-4qmkA:
undetectable		 4olmA-4qmkA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		5 LEU A 471
LEU A 467
LEU A 180
VAL A 330
MET A 166
 None
 1.25A 4olmA-4r1zA:
2.0		 4olmA-4r1zA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7s TETRATRICOPEPTIDE
REPEAT PROTEIN

(Parabacteroides
merdae) 		PF13432
(TPR_16) 		5 LEU A  62
LEU A  65
GLY A  66
GLN A  69
LEU A 102
 None
 0.86A 4olmA-4r7sA:
undetectable		 4olmA-4r7sA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rot ESTERASE A

(Streptococcus
pyogenes) 		PF00756
(Esterase) 		5 LEU A  45
GLY A 121
LEU A 246
VAL A  72
THR A  59
 None
 1.21A 4olmA-4rotA:
undetectable		 4olmA-4rotA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		5 LEU A 232
LEU A 229
GLY A 230
LEU A 161
VAL A 246
 None
 1.22A 4olmA-4rs3A:
undetectable		 4olmA-4rs3A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		5 LEU A 232
LEU A 229
GLY A 230
LEU A 161
VAL A 246
 None
 1.21A 4olmA-4rsmA:
undetectable		 4olmA-4rsmA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru0 PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		5 LEU A 362
LEU A 359
GLY A 358
LEU A 350
VAL A 335
 None
 1.32A 4olmA-4ru0A:
undetectable		 4olmA-4ru0A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru0 PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		5 LEU A 383
LEU A 381
GLY A 391
LEU A 152
THR A 139
 None
 1.40A 4olmA-4ru0A:
undetectable		 4olmA-4ru0A:
19.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 769
LEU A 772
GLN A 776
MET A 807
ARG A 817
 CV7  A1987 (-4.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
 0.66A 4olmA-4udbA:
33.0		 4olmA-4udbA:
52.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Geobacillus
kaustophilus) 		PF01680
(SOR_SNZ) 		5 LEU A  93
LEU A  96
GLY A  97
MET A  71
VAL A  70
 None
 1.07A 4olmA-4wxzA:
undetectable		 4olmA-4wxzA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x22 TRIOSEPHOSPHATE
ISOMERASE

(Leptospira
interrogans) 		PF00121
(TIM) 		5 LEU A 236
LEU A 213
GLY A 235
LEU A 250
VAL A  42
 None
 1.33A 4olmA-4x22A:
undetectable		 4olmA-4x22A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyi KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
japonicus) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		5 LEU A 185
GLY A 184
VAL A 206
HIS A 260
THR A 249
 None
 1.13A 4olmA-4xyiA:
undetectable		 4olmA-4xyiA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjp MONOSACCHARIDE-TRANS
PORTING ATPASE

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		5 LEU A 221
LEU A 218
GLY A 219
LEU A 152
VAL A 234
 None
 1.37A 4olmA-4zjpA:
undetectable		 4olmA-4zjpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3c SIR2 FAMILY PROTEIN

(Streptococcus
pyogenes) 		no annotation 5 LEU A 142
GLY A 138
MET A 198
VAL A 199
HIS A 205
 None
 1.32A 4olmA-5a3cA:
undetectable		 4olmA-5a3cA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.00A 4olmA-5d6nA:
undetectable		 4olmA-5d6nA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eso 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Mycobacterium
tuberculosis) 		PF02776
(TPP_enzyme_N) 		5 LEU A 416
LEU A  65
GLY A  64
VAL A 408
THR A 434
 None
 1.40A 4olmA-5esoA:
undetectable		 4olmA-5esoA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 0.98A 4olmA-5ey8A:
undetectable		 4olmA-5ey8A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32

(Mycobacterium
marinum) 		PF00501
(AMP-binding) 		5 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.08A 4olmA-5ey9A:
undetectable		 4olmA-5ey9A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA

(Caldalkalibacillus
thermarum) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 GLN A 113
LEU A  76
MET A  60
THR A  91
MET A  95
 None
 1.31A 4olmA-5ik2A:
undetectable		 4olmA-5ik2A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		5 LEU A 638
GLY A 637
LEU A 660
VAL A 477
THR A 654
 None
 1.13A 4olmA-5kqiA:
undetectable		 4olmA-5kqiA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 769
LEU A 772
GLN A 776
MET A 807
ARG A 817
 ECV  A1101 (-4.7A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
 0.65A 4olmA-5mwpA:
36.1		 4olmA-5mwpA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Homo sapiens) 		PF00443
(UCH) 		5 LEU A 138
LEU A  70
GLY A  69
GLN A  84
THR A 133
 None
 1.33A 4olmA-5ohkA:
undetectable		 4olmA-5ohkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3)
PF14598
(PAS_11) 		5 LEU A 343
GLY A 174
LEU B 146
HIS B 289
THR B 274
 None
 1.12A 4olmA-5sy5A:
undetectable		 4olmA-5sy5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzb D-AMINOPEPTIDASE

(Burkholderia
sp. LK4) 		PF03576
(Peptidase_S58) 		5 LEU A 133
LEU A 132
GLY A 131
HIS A 140
THR A  45
 None
 1.13A 4olmA-5tzbA:
undetectable		 4olmA-5tzbA:
19.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 GLY A 563
GLN A 566
MET A 597
MET A 600
ARG A 607
 486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
None
486  A 801 (-3.5A)
 0.81A 4olmA-5uc1A:
22.2		 4olmA-5uc1A:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 559
LEU A 562
GLY A 563
GLN A 566
MET A 600
ARG A 607
 486  A 801 (-4.7A)
486  A 801 ( 4.8A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
None
486  A 801 (-3.5A)
 0.81A 4olmA-5uc1A:
22.2		 4olmA-5uc1A:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  32
LEU A  35
GLY A  36
GLN A  39
MET A  70
ARG A  80
 1TA  A 301 (-3.5A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
 0.71A 4olmA-5ufsA:
34.0		 4olmA-5ufsA:
54.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  35
GLY A  36
GLN A  39
MET A  73
ARG A  80
 1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
 0.87A 4olmA-5ufsA:
34.0		 4olmA-5ufsA:
54.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq8 TYPE II SECRETION
SYSTEM PROTEIN D

(Vibrio cholerae) 		PF00263
(Secretin)
PF03958
(Secretin_N) 		5 LEU A 225
LEU A 228
LEU A 172
MET A 180
VAL A 181
 None
 1.16A 4olmA-5wq8A:
undetectable		 4olmA-5wq8A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvr KLLA0C04147P

(Kluyveromyces
lactis) 		PF01237
(Oxysterol_BP) 		5 LEU A1016
LEU A1017
GLY A1018
VAL A1012
ARG A1046
 SO4  A1302 (-4.3A)
SO4  A1302 (-3.6A)
None
None
SO4  A1302 ( 4.3A)
 1.28A 4olmA-5wvrA:
undetectable		 4olmA-5wvrA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxi EARP

(Neisseria
meningitidis) 		no annotation 5 LEU A  31
LEU A  35
GLY A  36
VAL A   7
HIS A  67
 None
 1.28A 4olmA-5wxiA:
undetectable		 4olmA-5wxiA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03739
(YjgP_YjgQ) 		5 LEU G 285
LEU G 107
MET G 106
MET G 103
VAL G 102
 None
 1.38A 4olmA-5x5yG:
undetectable		 4olmA-5x5yG:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		5 LEU C1260
LEU C1264
GLN C1231
LEU C1291
THR C1253
 None
 1.33A 4olmA-5y3rC:
undetectable		 4olmA-5y3rC:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzg PROTEIN ZIP2
SPORULATION-SPECIFIC
PROTEIN 16

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B 654
GLY B 655
MET A 151
VAL A 149
THR B 689
 None
 1.35A 4olmA-6bzgB:
undetectable		 4olmA-6bzgB:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b63 MUTL

(Escherichia
coli) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		4 MET A 263
ILE A 187
ILE A  42
VAL A 185
 None
 0.96A 4olmA-1b63A:
undetectable		 4olmA-1b63A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyg CYCLODEXTRIN
GLUCANOTRANSFERASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 MET A 230
ILE A 219
ILE A 215
VAL A 248
 None
 0.95A 4olmA-1cygA:
0.0		 4olmA-1cygA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2n CAPSID PROTEIN

(Rice yellow
mottle virus) 		PF00729
(Viral_coat) 		4 ASN A  84
ILE A 198
ILE A 186
VAL A 195
 None
 0.96A 4olmA-1f2nA:
0.0		 4olmA-1f2nA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASN A 103
ILE A  91
ILE A  92
VAL A  76
 None
 0.97A 4olmA-1fcpA:
undetectable		 4olmA-1fcpA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiu TYPE II RESTRICTION
ENZYME NGOMI

(Neisseria
gonorrhoeae) 		PF09015
(NgoMIV_restric) 		4 ASN A 197
ILE A 238
ILE A 231
VAL A 241
 ACY  A2001 (-3.6A)
None
None
None
 0.95A 4olmA-1fiuA:
0.0		 4olmA-1fiuA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g29 MALTOSE TRANSPORT
PROTEIN MALK

(Thermococcus
litoralis) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 MET 1 213
ILE 1  62
ILE 1  83
VAL 1 160
 None
 0.94A 4olmA-1g291:
0.0		 4olmA-1g291:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gns SUBTILISIN BPN'

(Bacillus
amyloliquefaciens) 		PF00082
(Peptidase_S8) 		4 MET A 119
ILE A 268
ILE A  11
VAL A 270
 None
 0.90A 4olmA-1gnsA:
0.0		 4olmA-1gnsA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1scj SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 MET A 119
ILE A 268
ILE A  11
VAL A 270
 None
 1.00A 4olmA-1scjA:
0.0		 4olmA-1scjA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		4 ASN A  83
ILE A  64
ILE A  15
VAL A  62
 None
 0.86A 4olmA-1sivA:
undetectable		 4olmA-1sivA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq5 PANTOTHENATE KINASE

(Escherichia
coli) 		PF00485
(PRK) 		4 MET A1029
ILE A1197
ILE A1195
VAL A1121
 None
 0.88A 4olmA-1sq5A:
0.0		 4olmA-1sq5A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdf THIOREDOXIN
REDUCTASE

(Escherichia
coli) 		PF07992
(Pyr_redox_2) 		4 ASN A 100
ILE A  34
ILE A  80
VAL A  32
 None
 0.90A 4olmA-1tdfA:
undetectable		 4olmA-1tdfA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud9 DNA POLYMERASE
SLIDING CLAMP A

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ASN A 106
ILE A  87
ILE A  88
VAL A   4
 None
 0.96A 4olmA-1ud9A:
undetectable		 4olmA-1ud9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wc5 ADENYLATE CYCLASE

(Arthrospira
platensis) 		PF00211
(Guanylate_cyc) 		4 MET A1073
ILE A1160
ILE A1195
VAL A1162
 None
 0.85A 4olmA-1wc5A:
undetectable		 4olmA-1wc5A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4g NUCLEOLYSIN TIAR

(Homo sapiens) 		PF00076
(RRM_1) 		4 MET A  53
ILE A  33
ILE A  86
VAL A  91
 None
 0.90A 4olmA-1x4gA:
undetectable		 4olmA-1x4gA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylococcus
capsulatus) 		PF02461
(AMO)
PF04744
(Monooxygenase_B) 		4 ASN A 168
ILE B 180
ILE B 183
VAL B 171
 None
 0.95A 4olmA-1yewA:
undetectable		 4olmA-1yewA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		4 ASN A 457
ILE A 570
ILE A 670
VAL A 565
 GAL  A 700 (-3.6A)
None
None
None
 1.02A 4olmA-1z45A:
undetectable		 4olmA-1z45A:
18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 705
MET A 749
MET A 787
ILE A 898
ILE A 899
VAL A 903
 BHM  A   1 (-3.6A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.6A)
None
None
None
 0.59A 4olmA-2ax9A:
40.0		 4olmA-2ax9A:
99.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		4 ASN A 330
MET A 384
ILE A 364
VAL A 357
 None
 1.01A 4olmA-2dw6A:
undetectable		 4olmA-2dw6A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		4 ASN A  50
MET A 342
ILE A  66
ILE A  70
 None
 0.99A 4olmA-2iy8A:
undetectable		 4olmA-2iy8A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 MET X 120
ILE X 107
ILE X 106
VAL X 113
 None
 1.00A 4olmA-2pmoX:
undetectable		 4olmA-2pmoX:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		4 ASN A  33
MET A 115
ILE A 226
ILE A 227
 1CA  A 247 (-2.9A)
1CA  A 247 ( 3.7A)
None
None
 0.79A 4olmA-2q3yA:
36.4		 4olmA-2q3yA:
59.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rc5 FERREDOXIN-NADP
REDUCTASE

(Leptospira
interrogans) 		PF00175
(NAD_binding_1) 		4 MET A 183
ILE A 283
ILE A 286
VAL A 282
 None
 0.91A 4olmA-2rc5A:
undetectable		 4olmA-2rc5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6e PROTELEMORASE

(Klebsiella
phage phiKO2) 		PF16684
(Telomere_res) 		4 MET A 276
ILE A 233
ILE A 531
VAL A 231
 None
 0.69A 4olmA-2v6eA:
undetectable		 4olmA-2v6eA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		4 ASN A 156
MET A  30
ILE A 190
VAL A 229
 None
 0.96A 4olmA-2x5fA:
undetectable		 4olmA-2x5fA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 ASN A 365
MET A 375
ILE A 486
VAL A 485
 None
 0.96A 4olmA-2xijA:
undetectable		 4olmA-2xijA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 MET A 655
ILE A 363
ILE A 366
VAL A 362
 None
 0.89A 4olmA-2xsgA:
undetectable		 4olmA-2xsgA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6i TRANS-2-ENOYL-ACP
REDUCTASE II

(Streptococcus
pneumoniae) 		PF03060
(NMO) 		4 MET A 103
ILE A  55
ILE A  41
VAL A  51
 None
 0.99A 4olmA-2z6iA:
undetectable		 4olmA-2z6iA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B

(Sulfolobus
shibatae) 		PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans) 		4 MET B 107
ILE B  56
ILE B  58
VAL B  74
 None
 0.88A 4olmA-2zbkB:
undetectable		 4olmA-2zbkB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrobaculum
aerophilum) 		PF07995
(GSDH) 		4 MET A 228
ILE A 146
ILE A 143
VAL A 124
 None
 0.95A 4olmA-3a9gA:
undetectable		 4olmA-3a9gA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bin BAND 4.1-LIKE
PROTEIN 3

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 MET A 295
ILE A 340
ILE A 349
VAL A 337
 None
 0.98A 4olmA-3binA:
undetectable		 4olmA-3binA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4r DOMAIN OF UNKNOWN
FUNCTION FROM THE
PFAM-B_34464 FAMILY

(Methanococcus
maripaludis) 		PF09891
(DUF2118) 		4 MET A  55
ILE A  20
ILE A  27
VAL A  18
 None
 0.99A 4olmA-3d4rA:
undetectable		 4olmA-3d4rA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e74 ALLANTOINASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 MET A 364
MET A 342
ILE A  30
ILE A  23
 None
 0.99A 4olmA-3e74A:
undetectable		 4olmA-3e74A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		4 ASN A  69
ILE A  78
ILE A  80
VAL A  57
 None
 1.00A 4olmA-3fydA:
undetectable		 4olmA-3fydA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjy SPERMIDINE SYNTHASE

(Corynebacterium
glutamicum) 		no annotation 4 ASN A 113
ILE A 160
ILE A 161
VAL A 194
 None
 0.94A 4olmA-3gjyA:
undetectable		 4olmA-3gjyA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpv TRANSCRIPTIONAL
REGULATOR, MERR
FAMILY

(Bacillus
thuringiensis) 		PF13411
(MerR_1) 		4 MET A  92
ILE A  24
ILE A  38
VAL A  27
 None
 0.97A 4olmA-3gpvA:
undetectable		 4olmA-3gpvA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdy UDP-GALACTOPYRANOSE
MUTASE

(Deinococcus
radiodurans) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 ASN A 228
MET A 373
ILE A 235
VAL A 237
 None
FAD  A 450 (-4.4A)
None
None
 0.79A 4olmA-3hdyA:
undetectable		 4olmA-3hdyA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j47 26S PROTEASOME
REGULATORY SUBUNIT
RPN6
26S PROTEASOME
REGULATORY SUBUNIT
RPN8

(Saccharomyces
cerevisiae) 		PF13012
(MitMem_reg)
no annotation 		4 ASN Q 420
ILE U 286
ILE U 285
VAL U 282
 None
 0.93A 4olmA-3j47Q:
undetectable		 4olmA-3j47Q:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE

(Listeria
monocytogenes) 		PF00563
(EAL) 		4 ASN A 198
ILE A 146
ILE A 169
VAL A 149
 None
 1.00A 4olmA-3kzpA:
undetectable		 4olmA-3kzpA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldh LACTATE
DEHYDROGENASE

(Squalus
acanthias) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 MET A 274
ILE A  96
ILE A 127
VAL A  94
 None
 1.02A 4olmA-3ldhA:
undetectable		 4olmA-3ldhA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Ruegeria sp.
TM1040) 		PF04952
(AstE_AspA) 		4 MET A 201
ILE A  38
ILE A  40
VAL A  87
 None
 1.00A 4olmA-3na6A:
undetectable		 4olmA-3na6A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of1 CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT

(Saccharomyces
cerevisiae) 		PF00027
(cNMP_binding) 		4 MET A 300
ILE A 330
ILE A 329
VAL A 381
 None
CMP  A 601 (-4.8A)
None
None
 1.01A 4olmA-3of1A:
undetectable		 4olmA-3of1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk9 MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM44

(Saccharomyces
cerevisiae) 		PF04280
(Tim44) 		4 MET A 254
ILE A 301
ILE A 297
VAL A 298
 None
 0.99A 4olmA-3qk9A:
undetectable		 4olmA-3qk9A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhg PUTATIVE
PHOPHOTRIESTERASE

(Proteus
mirabilis) 		PF02126
(PTE) 		4 ASN A  82
ILE A  92
ILE A 117
VAL A 119
 None
 0.89A 4olmA-3rhgA:
undetectable		 4olmA-3rhgA:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		4 ASN A  33
MET A 115
ILE A 226
ILE A 227
 1CA  A 249 (-3.0A)
1CA  A 249 (-3.6A)
None
None
 0.78A 4olmA-3ry9A:
35.7		 4olmA-3ry9A:
54.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttp HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 ASN A  83
ILE A  64
ILE A  15
VAL A  62
 None
 0.79A 4olmA-3ttpA:
undetectable		 4olmA-3ttpA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1j SERINE PROTEASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7) 		4 ASN B 108
ILE B 139
ILE B 140
VAL B 146
 None
 0.98A 4olmA-3u1jB:
undetectable		 4olmA-3u1jB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whi SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		4 MET A 209
ILE A 358
ILE A 101
VAL A 360
 None
 0.98A 4olmA-3whiA:
undetectable		 4olmA-3whiA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 MET A 641
ILE A 297
ILE A 295
VAL A 307
 None
 0.90A 4olmA-3wiqA:
undetectable		 4olmA-3wiqA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7x PROBABLE
OXIDOREDUCTASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 MET A 276
ILE A 236
ILE A 217
VAL A 232
 NAP  A 400 (-3.6A)
None
None
None
 0.74A 4olmA-4b7xA:
undetectable		 4olmA-4b7xA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bih UNCHARACTERIZED
LIPOPROTEIN
SAOUHSC_00053

(Staphylococcus
aureus) 		PF04507
(DUF576) 		4 ASN A 132
ILE A 135
ILE A 134
VAL A 127
 None
 1.01A 4olmA-4bihA:
undetectable		 4olmA-4bihA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL PROTEIN
SKI8

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 MET C 119
ILE C 194
ILE C 200
VAL C 192
 None
 0.98A 4olmA-4bujC:
undetectable		 4olmA-4bujC:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djf CORRINOID/IRON-SULFU
R PROTEIN LARGE
SUBUNIT

(Moorella
thermoacetica) 		PF03599
(CdhD)
PF04060
(FeS) 		4 ASN C 115
ILE C  96
ILE C 131
VAL C  98
 None
 0.83A 4olmA-4djfC:
undetectable		 4olmA-4djfC:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz4 AGMATINASE

(Burkholderia
thailandensis) 		PF00491
(Arginase) 		4 MET A 178
ILE A 231
ILE A 228
VAL A 232
 None
 0.90A 4olmA-4dz4A:
undetectable		 4olmA-4dz4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eg9 UNCHARACTERIZED
PROTEIN
SAOUHSC_02783

(Staphylococcus
aureus) 		PF04507
(DUF576) 		4 ASN A 136
ILE A 139
ILE A 138
VAL A 131
 None
 0.86A 4olmA-4eg9A:
undetectable		 4olmA-4eg9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE

(Parabacteroides
distasonis) 		PF13859
(BNR_3)
PF14873
(BNR_assoc_N) 		4 ASN A 163
ILE A  23
ILE A 173
VAL A  25
 None
 0.90A 4olmA-4fj6A:
undetectable		 4olmA-4fj6A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gud IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH

(Vibrio cholerae) 		PF00117
(GATase) 		4 ASN A  14
ILE A  31
ILE A   7
VAL A  29
 None
 0.82A 4olmA-4gudA:
undetectable		 4olmA-4gudA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ASN A 645
ILE A 633
ILE A 632
VAL A 619
 None
 0.99A 4olmA-4iglA:
undetectable		 4olmA-4iglA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikn AP-3 COMPLEX SUBUNIT
MU-1

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		4 ASN A 372
ILE A 191
ILE A 190
VAL A 198
 ASN  A 372 ( 0.6A)
ILE  A 191 ( 0.7A)
ILE  A 190 ( 0.7A)
VAL  A 198 ( 0.6A)
 0.89A 4olmA-4iknA:
undetectable		 4olmA-4iknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv5 ASPARTATE
CARBAMOYLTRANSFERASE
, PUTATIVE

(Trypanosoma
cruzi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 MET A 317
ILE A 162
ILE A 164
VAL A 237
 None
 0.96A 4olmA-4iv5A:
undetectable		 4olmA-4iv5A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		4 MET A 270
ILE A   9
ILE A 253
VAL A  42
 None
 1.01A 4olmA-4jn6A:
undetectable		 4olmA-4jn6A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq8 CYTOCHROME P450 19A1

(Homo sapiens) 		PF00067
(p450) 		4 MET A 160
MET A 446
ILE A 132
ILE A 133
 None
None
HEM  A 601 (-3.8A)
ASD  A 602 (-4.0A)
 0.91A 4olmA-4kq8A:
1.7		 4olmA-4kq8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kyi VIPD

(Legionella
pneumophila) 		PF01734
(Patatin) 		4 ASN A 178
ILE A 121
ILE A 176
VAL A 124
 None
 0.99A 4olmA-4kyiA:
undetectable		 4olmA-4kyiA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lis UDP-GLUCOSE
4-EPIMERASE

(Aspergillus
nidulans) 		PF16363
(GDP_Man_Dehyd) 		4 ASN A 122
ILE A 167
ILE A 171
VAL A 170
 None
None
None
IOD  A 406 ( 4.9A)
 0.95A 4olmA-4lisA:
undetectable		 4olmA-4lisA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8x CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN

(Nostoc sp. PCC
7120) 		PF03319
(EutN_CcmL) 		4 ASN 1  35
ILE 1  86
ILE 1  93
VAL 1  88
 None
 1.02A 4olmA-4n8x1:
undetectable		 4olmA-4n8x1:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		4 MET A 170
ILE A 108
ILE A 109
VAL A 112
 None
 0.99A 4olmA-4pspA:
undetectable		 4olmA-4pspA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxd ALLANTOATE
AMIDOHYDROLASE

(Escherichia
coli) 		PF01546
(Peptidase_M20) 		4 ASN A 304
ILE A 317
ILE A 319
VAL A 218
 None
 1.01A 4olmA-4pxdA:
undetectable		 4olmA-4pxdA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04998
(RNA_pol_Rpb1_5) 		4 MET B1035
ILE C 101
ILE C 102
VAL C 105
 None
 0.90A 4olmA-4qiwB:
undetectable		 4olmA-4qiwB:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrk HYPOTHETICAL PROTEIN

(Clostridium
sporogenes) 		PF09922
(DUF2154)
PF17115
(Toast_rack_N) 		4 ASN A 234
ILE A 244
ILE A 242
VAL A 206
 None
 0.98A 4olmA-4qrkA:
undetectable		 4olmA-4qrkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rph UDP-GALACTOPYRANOSE
MUTASE

(Mycobacterium
tuberculosis) 		no annotation 4 ASN B 210
MET B 369
ILE B 217
VAL B 219
 None
FAD  B 401 (-4.4A)
None
None
 0.78A 4olmA-4rphB:
undetectable		 4olmA-4rphB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		4 ASN A 684
ILE A 194
ILE A 195
VAL A 198
 None
 0.95A 4olmA-4u1rA:
undetectable		 4olmA-4u1rA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgk UDP-GALACTOPYRANOSE
MUTASE

(Corynebacterium
diphtheriae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 ASN A 206
MET A 367
ILE A 213
VAL A 215
 None
FDA  A 403 (-4.2A)
None
None
 0.70A 4olmA-4xgkA:
undetectable		 4olmA-4xgkA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk8 MEIOTICALLY
UP-REGULATED GENE 66
PROTEIN

(Schizosaccharomyces
pombe) 		PF07855
(ATG101) 		4 ASN A  57
MET A  81
ILE A  41
VAL A  43
 None
 0.96A 4olmA-4yk8A:
undetectable		 4olmA-4yk8A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ASN A 391
ILE A 375
ILE A 397
VAL A 377
 None
 0.84A 4olmA-4ypjA:
undetectable		 4olmA-4ypjA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a35 GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Streptococcus
pyogenes) 		PF01597
(GCV_H) 		4 ASN A   6
ILE A  93
ILE A  19
VAL A  94
 None
 0.83A 4olmA-5a35A:
undetectable		 4olmA-5a35A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ar6 RIBONUCLEASE 4

(Sus scrofa) 		PF00074
(RnaseA) 		4 MET A   0
ILE A  50
ILE A  53
VAL A  13
 None
None
None
EDO  A1120 (-4.4A)
 0.99A 4olmA-5ar6A:
undetectable		 4olmA-5ar6A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)

(Bdellovibrio
bacteriovorus) 		PF06963
(FPN1) 		4 ASN A 375
ILE A 132
ILE A  68
VAL A  76
 None
 0.99A 4olmA-5aynA:
undetectable		 4olmA-5aynA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esc HUPZ

(Streptococcus
sp. 'group A') 		PF01243
(Putative_PNPOx) 		4 MET A 101
ILE A  62
ILE A  64
VAL A  17
 None
 1.00A 4olmA-5escA:
undetectable		 4olmA-5escA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl3 PILI RETRACTION
PROTEIN PILT

(Thermus
thermophilus) 		PF00437
(T2SSE) 		4 MET A 211
ILE A 295
ILE A 293
VAL A 124
 None
 0.97A 4olmA-5fl3A:
undetectable		 4olmA-5fl3A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqf LACTO-N-BIOSIDASE

(Bifidobacterium
longum) 		no annotation 4 ASN A 333
ILE A 234
ILE A 251
VAL A 214
 None
 0.94A 4olmA-5gqfA:
undetectable		 4olmA-5gqfA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hci GPN-LOOP GTPASE 1

(Saccharomyces
cerevisiae) 		PF03029
(ATP_bind_1) 		4 MET A  20
ILE A  86
ILE A  90
VAL A  89
 None
 1.01A 4olmA-5hciA:
undetectable		 4olmA-5hciA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjd COLLAGEN TYPE IV
ALPHA-3-BINDING
PROTEIN

(Homo sapiens) 		PF01852
(START) 		4 ASN B 504
ILE B 464
ILE B 465
VAL B 454
 PGE  B 604 (-4.0A)
None
None
None
 0.99A 4olmA-5jjdB:
undetectable		 4olmA-5jjdB:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 MET A 279
ILE A 395
ILE A 398
VAL A 130
 None
 0.86A 4olmA-5lnqA:
undetectable		 4olmA-5lnqA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm2 CAPSID PROTEIN VP4B

(Nora virus) 		no annotation 4 MET B  71
ILE B 119
ILE B 121
VAL B 205
 None
 0.94A 4olmA-5mm2B:
undetectable		 4olmA-5mm2B:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 4 ASN A 770
MET A 852
ILE A 963
ILE A 964
 ECV  A1101 (-3.1A)
ECV  A1101 (-3.7A)
None
None
 0.72A 4olmA-5mwpA:
36.1		 4olmA-5mwpA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nc8 POTASSIUM EFFLUX
SYSTEM PROTEIN

(Shewanella
denitrificans) 		PF02254
(TrkA_N) 		4 ASN A 450
ILE A 410
ILE A 411
VAL A 475
 None
 1.01A 4olmA-5nc8A:
undetectable		 4olmA-5nc8A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 4 ASN A1284
ILE A1214
ILE A1213
VAL A1195
 None
 0.94A 4olmA-5ngyA:
undetectable		 4olmA-5ngyA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B

(Pseudomonas
aeruginosa) 		no annotation 4 MET A 171
ILE A  99
ILE A  98
VAL A  94
 CAC  A 402 (-4.2A)
None
None
None
 0.95A 4olmA-5o8xA:
undetectable		 4olmA-5o8xA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 4 MET A 529
ILE A 608
ILE A 368
VAL A 374
 None
 0.95A 4olmA-5opqA:
undetectable		 4olmA-5opqA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szm PCDHGA8 OR
PROTOCADHERIN GAMMA
A8

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 ASN A 146
ILE A 199
ILE A 201
VAL A 111
 None
 0.96A 4olmA-5szmA:
undetectable		 4olmA-5szmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2z PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 ASN A  83
ILE A  64
ILE A  15
VAL A  62
 None
 0.96A 4olmA-5t2zA:
undetectable		 4olmA-5t2zA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tk6 OXSA PROTEIN

(Bacillus
megaterium) 		PF12917
(HD_2) 		4 ASN A  55
ILE A 127
ILE A 124
VAL A 128
 None
 0.99A 4olmA-5tk6A:
2.2		 4olmA-5tk6A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpc BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 MET A1004
ILE A 983
ILE A 984
VAL A 998
 None
 1.02A 4olmA-5tpcA:
undetectable		 4olmA-5tpcA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqz GLUCAN-BINDING
PROTEIN C, GBPC

(Streptococcus
mutans) 		no annotation 4 ASN A 264
ILE A 272
ILE A 262
VAL A 275
 None
 0.98A 4olmA-5uqzA:
undetectable		 4olmA-5uqzA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze4 DIHYDROXY-ACID
DEHYDRATASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 MET A 102
ILE A  94
ILE A 117
VAL A  59
 None
 0.91A 4olmA-5ze4A:
undetectable		 4olmA-5ze4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 MET A 215
ILE A 304
ILE A 305
VAL A 308
 None
 1.01A 4olmA-5zqzA:
undetectable		 4olmA-5zqzA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5

(Aquareovirus C) 		no annotation 4 MET 4 424
ILE 4 314
ILE 4 292
VAL 4 317
 None
 1.00A 4olmA-5zvs4:
undetectable		 4olmA-5zvs4:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1

(Danio rerio) 		no annotation 4 MET A 372
ILE A 155
ILE A 159
VAL A 191
 HEM  A 601 ( 4.4A)
None
None
None
 0.93A 4olmA-6b82A:
undetectable		 4olmA-6b82A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 4 ASN A 644
ILE A 668
ILE A 646
VAL A 670
 None
 0.92A 4olmA-6f91A:
undetectable		 4olmA-6f91A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fiv RETROPEPSIN

(Feline
immunodeficiency
virus) 		PF00077
(RVP) 		4 MET A  56
ILE A  18
ILE A  25
VAL A  20
 3TL  A 201 (-4.7A)
None
None
None
 1.02A 4olmA-6fivA:
undetectable		 4olmA-6fivA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5

(Mus musculus) 		no annotation 4 MET L 421
ILE L 395
ILE L 399
VAL L 315
 None
 0.91A 4olmA-6g2jL:
undetectable		 4olmA-6g2jL:
14.17