SIMILAR PATTERNS OF AMINO ACIDS FOR 4OLB_A_TRPA901_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad1 DIHYDROPTEROATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00809
(Pterin_bind) 		3 VAL A  12
ALA A  29
PHE A  17
 None
 0.89A 4olbA-1ad1A:
undetectable		 4olbA-1ad1A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		3 VAL A 957
ALA A 962
PHE A1048
 None
 0.91A 4olbA-1c30A:
3.7		 4olbA-1c30A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dt2 EXFOLIATIVE TOXIN B

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		3 VAL A  39
ALA A  82
PHE A  79
 None
 0.79A 4olbA-1dt2A:
undetectable		 4olbA-1dt2A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanopyrus
kandleri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		3 VAL B  47
ALA B 177
PHE B 420
 None
 0.92A 4olbA-1e6vB:
0.0		 4olbA-1e6vB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00478
(IMPDH) 		3 VAL A 271
ALA A 261
PHE A  12
 None
 0.89A 4olbA-1eepA:
2.4		 4olbA-1eepA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp3 N-ACYL-D-GLUCOSAMINE
2-EPIMERASE

(Sus scrofa) 		PF07221
(GlcNAc_2-epim) 		3 VAL A  62
ALA A  86
PHE A  38
 None
 0.92A 4olbA-1fp3A:
undetectable		 4olbA-1fp3A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fy2 ASPARTYL DIPEPTIDASE

(Salmonella
enterica) 		PF03575
(Peptidase_S51) 		3 VAL A  85
ALA A  40
PHE A  36
 None
 0.93A 4olbA-1fy2A:
0.0		 4olbA-1fy2A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0u PROTEASOME COMPONENT
PUP2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		3 VAL D  68
ALA D  77
PHE D 221
 None
 0.71A 4olbA-1g0uD:
0.0		 4olbA-1g0uD:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy8 UDP-GALACTOSE
4-EPIMERASE

(Trypanosoma
brucei) 		PF01370
(Epimerase) 		3 VAL A 343
ALA A 345
PHE A 201
 None
 0.78A 4olbA-1gy8A:
2.9		 4olbA-1gy8A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		3 VAL A 382
ALA A 399
PHE A 363
 None
 0.75A 4olbA-1h39A:
undetectable		 4olbA-1h39A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 VAL B 439
ALA B 271
PHE B 251
 None
 0.91A 4olbA-1hr7B:
undetectable		 4olbA-1hr7B:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwn EBULIN

(Sambucus ebulus) 		PF00161
(RIP) 		3 VAL A 150
ALA A 123
PHE A 112
 None
 0.89A 4olbA-1hwnA:
undetectable		 4olbA-1hwnA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE

(Escherichia
coli) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		3 VAL A  73
ALA A  86
PHE A  55
 None
 0.89A 4olbA-1kqjA:
undetectable		 4olbA-1kqjA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 VAL B 212
ALA B 708
PHE B 731
 None
 0.90A 4olbA-1n60B:
undetectable		 4olbA-1n60B:
22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607

(Haemophilus
influenzae) 		PF08501
(Shikimate_dh_N) 		3 VAL A 240
ALA A 263
PHE A  19
 None
 0.74A 4olbA-1npyA:
undetectable		 4olbA-1npyA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 VAL A 121
ALA A 149
PHE A 102
 None
 0.73A 4olbA-1nr0A:
undetectable		 4olbA-1nr0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 VAL A 278
ALA A 254
PHE A 335
 None
 0.93A 4olbA-1odoA:
undetectable		 4olbA-1odoA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oll NK RECEPTOR

(Homo sapiens) 		no annotation 3 VAL A 147
ALA A 125
PHE A 129
 None
 0.88A 4olbA-1ollA:
undetectable		 4olbA-1ollA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF

(Saccharomyces
cerevisiae) 		PF00117
(GATase)
PF00977
(His_biosynth) 		3 VAL B 182
ALA B 180
PHE B 134
 None
 0.93A 4olbA-1ox4B:
2.4		 4olbA-1ox4B:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvm CONSERVED
HYPOTHETICAL PROTEIN
TA0289

(Thermoplasma
acidophilum) 		PF00571
(CBS)
PF09151
(DUF1936) 		3 VAL A 113
ALA A 104
PHE A  13
 None
 0.89A 4olbA-1pvmA:
undetectable		 4olbA-1pvmA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		3 VAL A 289
ALA A 252
PHE A 298
 None
 0.93A 4olbA-1ru4A:
undetectable		 4olbA-1ru4A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry4 CG5884-PA

(Drosophila
melanogaster) 		PF00595
(PDZ) 		3 VAL A 145
ALA A 147
PHE A 142
 None
 0.81A 4olbA-1ry4A:
undetectable		 4olbA-1ry4A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sml PROTEIN
(PENICILLINASE)

(Stenotrophomonas
maltophilia) 		PF00753
(Lactamase_B) 		3 VAL A 139
ALA A 108
PHE A 156
 None
 0.80A 4olbA-1smlA:
undetectable		 4olbA-1smlA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Zea mays) 		PF00903
(Glyoxalase) 		3 VAL A 299
ALA A 134
PHE A 290
 None
 0.56A 4olbA-1sp8A:
undetectable		 4olbA-1sp8A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		3 VAL A 116
ALA A 114
PHE A  68
 None
 0.92A 4olbA-1t8hA:
undetectable		 4olbA-1t8hA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux7 ENDO-1,4-BETA-XYLANA
SE D

(Paenibacillus
polymyxa) 		PF03422
(CBM_6) 		3 VAL A 124
ALA A  38
PHE A  34
 None
 0.92A 4olbA-1ux7A:
undetectable		 4olbA-1ux7A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkm METHIONINE
AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24) 		3 VAL A  83
ALA A  92
PHE A  50
 None
None
MET  A1298 (-3.8A)
 0.89A 4olbA-1wkmA:
undetectable		 4olbA-1wkmA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5c PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF00085
(Thioredoxin) 		3 VAL A  28
ALA A  88
PHE A  85
 None
 0.77A 4olbA-1x5cA:
undetectable		 4olbA-1x5cA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 VAL A 364
ALA A 362
PHE A 295
 None
 0.85A 4olbA-1xmbA:
2.6		 4olbA-1xmbA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3j COPPER-TRANSPORTING
ATPASE 1

(Homo sapiens) 		PF00403
(HMA) 		3 VAL A  18
ALA A  43
PHE A  66
 None
 0.90A 4olbA-1y3jA:
2.6		 4olbA-1y3jA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzp PEROXIDASE
MANGANESE-DEPENDENT
I

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		3 VAL A 137
ALA A 135
PHE A  77
 None
 0.65A 4olbA-1yzpA:
undetectable		 4olbA-1yzpA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zoi ESTERASE

(Pseudomonas
putida) 		PF00561
(Abhydrolase_1) 		3 VAL A 219
ALA A 247
PHE A 273
 None
 0.87A 4olbA-1zoiA:
4.8		 4olbA-1zoiA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)

(Black beetle
virus) 		PF01829
(Peptidase_A6) 		3 VAL A 285
ALA A 280
PHE A 148
 None
 0.85A 4olbA-2bbvA:
undetectable		 4olbA-2bbvA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmm PROTEIN
DISULFIDE-ISOMERASE
A3

(Homo sapiens) 		PF00085
(Thioredoxin) 		3 VAL A  48
ALA A 109
PHE A 106
 None
 0.75A 4olbA-2dmmA:
undetectable		 4olbA-2dmmA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		3 VAL A 214
ALA A 212
PHE A 360
 None
 0.79A 4olbA-2e7uA:
2.9		 4olbA-2e7uA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Aeropyrum
pernix) 		PF00202
(Aminotran_3) 		3 VAL A 218
ALA A 216
PHE A 364
 None
 0.75A 4olbA-2epjA:
2.6		 4olbA-2epjA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fom POLYPROTEIN

(Dengue virus) 		PF00949
(Peptidase_S7) 		3 VAL B  40
ALA B  38
PHE B  46
 None
 0.89A 4olbA-2fomB:
undetectable		 4olbA-2fomB:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fp7 GENOME POLYPROTEIN

(West Nile virus) 		PF00949
(Peptidase_S7) 		3 VAL B  40
ALA B  38
PHE B  46
 None
 0.85A 4olbA-2fp7B:
undetectable		 4olbA-2fp7B:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvm DIHYDROPYRIMIDINASE

(Lachancea
kluyveri) 		PF01979
(Amidohydro_1) 		3 VAL A  63
ALA A  61
PHE A  97
 None
None
KCX  A 167 ( 4.5A)
 0.86A 4olbA-2fvmA:
undetectable		 4olbA-2fvmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g39 ACETYL-COA HYDROLASE

(Pseudomonas
aeruginosa) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		3 VAL A 427
ALA A 433
PHE A 360
 None
 0.93A 4olbA-2g39A:
undetectable		 4olbA-2g39A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh9 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		3 VAL A 273
ALA A 275
PHE A  46
 None
 0.86A 4olbA-2gh9A:
undetectable		 4olbA-2gh9A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i8l HYDROGENASE 3
MATURATION PROTEASE

(Escherichia
coli) 		PF01750
(HycI) 		3 VAL A  61
ALA A  63
PHE A 110
 None
 0.93A 4olbA-2i8lA:
undetectable		 4olbA-2i8lA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iic ALPHA-11 GIARDIN

(Giardia
intestinalis) 		no annotation 3 VAL A  96
ALA A 100
PHE A 259
 None
 0.93A 4olbA-2iicA:
undetectable		 4olbA-2iicA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		3 VAL A 334
ALA A 505
PHE A 389
 None
 0.92A 4olbA-2jgpA:
undetectable		 4olbA-2jgpA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbp LEUCINE-BINDING
PROTEIN

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		3 VAL A   8
ALA A  10
PHE A  23
 None
 0.93A 4olbA-2lbpA:
4.8		 4olbA-2lbpA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2liv LEUCINE

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		3 VAL A   8
ALA A  10
PHE A  23
 None
 0.79A 4olbA-2livA:
4.5		 4olbA-2livA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lm5 CALCIUM AND
INTEGRIN-BINDING
PROTEIN 1

(Homo sapiens) 		PF13499
(EF-hand_7) 		3 VAL A 190
ALA A 111
PHE A  98
 None
 0.87A 4olbA-2lm5A:
undetectable		 4olbA-2lm5A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2msx KUNITZ-TYPE PROTEASE
INHIBITOR 1

(Homo sapiens) 		PF07502
(MANEC) 		3 VAL A 102
ALA A 114
PHE A 117
 None
 0.80A 4olbA-2msxA:
undetectable		 4olbA-2msxA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np3 PUTATIVE TETR-FAMILY
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		3 VAL A 128
ALA A 138
PHE A  78
 None
 0.85A 4olbA-2np3A:
undetectable		 4olbA-2np3A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozg GCN5-RELATED
N-ACETYLTRANSFERASE

(Trichormus
variabilis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 VAL A  84
ALA A  82
PHE A  30
 COA  A 500 (-3.8A)
None
COA  A 500 ( 4.5A)
 0.91A 4olbA-2ozgA:
undetectable		 4olbA-2ozgA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 VAL A 922
ALA A 867
PHE A 850
 None
 0.90A 4olbA-2pffA:
3.1		 4olbA-2pffA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4

(Azotobacter
vinelandii) 		PF12708
(Pectate_lyase_3) 		3 VAL A 189
ALA A 167
PHE A 198
 None
 0.92A 4olbA-2pyhA:
undetectable		 4olbA-2pyhA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		3 VAL A 115
ALA A 425
PHE A   7
 None
 0.93A 4olbA-2q01A:
undetectable		 4olbA-2q01A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		3 VAL A 173
ALA A 171
PHE A 211
 None
 0.73A 4olbA-2rfaA:
undetectable		 4olbA-2rfaA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgt FUSION OF
LIM/HOMEOBOX PROTEIN
LHX3, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-1

(Mus musculus;
synthetic
construct) 		PF00412
(LIM) 		3 VAL A 266
ALA A 268
PHE A 134
 None
 0.87A 4olbA-2rgtA:
undetectable		 4olbA-2rgtA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 VAL B  67
ALA B  69
PHE B 173
 None
 0.74A 4olbA-2v4jB:
undetectable		 4olbA-2v4jB:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vri NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
NL63) 		PF01661
(Macro) 		3 VAL A  74
ALA A  72
PHE A  84
 None
 0.93A 4olbA-2vriA:
2.6		 4olbA-2vriA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc1 FLAVODOXIN

(Rhodobacter
capsulatus) 		PF00258
(Flavodoxin_1) 		3 VAL A 179
ALA A 173
PHE A  26
 None
 0.92A 4olbA-2wc1A:
3.3		 4olbA-2wc1A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wxu PHOSPHOLIPASE C

(Clostridium
perfringens) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		3 VAL A 140
ALA A 142
PHE A  69
 None
 0.91A 4olbA-2wxuA:
undetectable		 4olbA-2wxuA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY

(Staphylococcus
aureus) 		PF00561
(Abhydrolase_1) 		3 VAL A  43
ALA A   9
PHE A   6
 None
 0.74A 4olbA-2xmzA:
2.7		 4olbA-2xmzA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy ENVELOPE
GLYCOPROTEIN H

(Suid
alphaherpesvirus
1) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		3 VAL A 163
ALA A 270
PHE A 319
 None
 0.92A 4olbA-2xqyA:
undetectable		 4olbA-2xqyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		3 VAL A  44
ALA A 276
PHE A  71
 None
 0.93A 4olbA-2xuzA:
5.0		 4olbA-2xuzA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		3 VAL A 205
ALA A 235
PHE A 232
 None
 0.42A 4olbA-2yp1A:
undetectable		 4olbA-2yp1A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE

(Thermus
thermophilus) 		PF03747
(ADP_ribosyl_GH) 		3 VAL A 206
ALA A 189
PHE A 210
 None
 0.85A 4olbA-2yzwA:
undetectable		 4olbA-2yzwA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		3 VAL A  29
ALA A  37
PHE A 137
 None
 0.86A 4olbA-3aq0A:
undetectable		 4olbA-3aq0A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdv UNCHARACTERIZED
PROTEIN DUF1234

(Pectobacterium
atrosepticum) 		PF06821
(Ser_hydrolase) 		3 VAL A 101
ALA A  99
PHE A 182
 None
 0.90A 4olbA-3bdvA:
5.9		 4olbA-3bdvA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		3 VAL A 831
ALA A 798
PHE A 598
 None
 0.72A 4olbA-3bg9A:
2.1		 4olbA-3bg9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		3 VAL A 364
ALA A 322
PHE A 420
 None
 0.91A 4olbA-3c6gA:
undetectable		 4olbA-3c6gA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ds8 LIN2722 PROTEIN

(Listeria
innocua) 		PF06028
(DUF915) 		3 VAL A 174
ALA A 209
PHE A 238
 None
 0.92A 4olbA-3ds8A:
3.5		 4olbA-3ds8A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egj N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Vibrio cholerae) 		PF01979
(Amidohydro_1) 		3 VAL A 228
ALA A 211
PHE A 204
 None
 0.79A 4olbA-3egjA:
undetectable		 4olbA-3egjA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6q LIM AND SENESCENT
CELL
ANTIGEN-LIKE-CONTAIN
ING DOMAIN PROTEIN 1

(Homo sapiens) 		PF00412
(LIM) 		3 VAL B  37
ALA B  39
PHE B  45
 None
 0.84A 4olbA-3f6qB:
undetectable		 4olbA-3f6qB:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)

(Salmonella
enterica) 		PF09982
(DUF2219) 		3 VAL A 223
ALA A 183
PHE A 199
 CXE  A 307 (-4.3A)
CXE  A 306 ( 4.4A)
None
 0.82A 4olbA-3fidA:
undetectable		 4olbA-3fidA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7s LONG-CHAIN-FATTY-ACI
D--COA LIGASE
(FADD-1)

(Archaeoglobus
fulgidus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 VAL A 241
ALA A  25
PHE A  30
 None
 0.82A 4olbA-3g7sA:
2.6		 4olbA-3g7sA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL

(Escherichia
coli) 		PF00936
(BMC) 		3 VAL A 152
ALA A 188
PHE A 204
 None
 0.73A 4olbA-3gfhA:
undetectable		 4olbA-3gfhA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2u RAVER-1

(Homo sapiens) 		PF00076
(RRM_1) 		3 VAL B 235
ALA B 265
PHE B 232
 None
 0.88A 4olbA-3h2uB:
3.6		 4olbA-3h2uB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 VAL A  71
ALA A  45
PHE A 118
 None
 0.93A 4olbA-3h9uA:
undetectable		 4olbA-3h9uA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 VAL A  71
ALA A  48
PHE A 118
 None
 0.93A 4olbA-3h9uA:
undetectable		 4olbA-3h9uA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE

(Cytophaga
hutchinsonii) 		PF01841
(Transglut_core) 		3 VAL A 169
ALA A 167
PHE A 173
 None
 0.91A 4olbA-3isrA:
undetectable		 4olbA-3isrA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixe LIM AND SENESCENT
CELL
ANTIGEN-LIKE-CONTAIN
ING DOMAIN PROTEIN 2

(Homo sapiens) 		PF00412
(LIM) 		3 VAL B  37
ALA B  39
PHE B  45
 None
 0.92A 4olbA-3ixeB:
undetectable		 4olbA-3ixeB:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixl ARYLMALONATE
DECARBOXYLASE

(Bordetella
bronchiseptica) 		no annotation 3 VAL A  20
ALA A  25
PHE A 216
 None
 0.90A 4olbA-3ixlA:
6.1		 4olbA-3ixlA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF00465
(Fe-ADH) 		3 VAL A 354
ALA A 309
PHE A 298
 None
 0.70A 4olbA-3jzdA:
3.4		 4olbA-3jzdA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkb PROBABLE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER, AMINO
ACID BINDING PROTEIN

(Thermus
thermophilus) 		PF13458
(Peripla_BP_6) 		3 VAL A 203
ALA A 230
PHE A 249
 None
 0.90A 4olbA-3lkbA:
5.7		 4olbA-3lkbA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o31 THERMONICOTIANAMINE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF03059
(NAS) 		3 VAL A 194
ALA A 196
PHE A 128
 None
3O3  A   1 (-3.4A)
BR  A 298 ( 4.8A)
 0.93A 4olbA-3o31A:
undetectable		 4olbA-3o31A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pk0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		3 VAL A  58
ALA A  31
PHE A  82
 None
 0.93A 4olbA-3pk0A:
2.8		 4olbA-3pk0A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnz PHOSPHOTRIESTERASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF02126
(PTE) 		3 VAL A  90
ALA A 150
PHE A   7
 None
 0.91A 4olbA-3pnzA:
undetectable		 4olbA-3pnzA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppx VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		3 VAL A1499
ALA A1602
PHE A1552
 None
NA  A   1 ( 3.9A)
None
 0.66A 4olbA-3ppxA:
2.2		 4olbA-3ppxA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		3 VAL B 302
ALA B 334
PHE B 314
 None
 0.75A 4olbA-3q75B:
undetectable		 4olbA-3q75B:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfk UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		3 VAL A 322
ALA A 320
PHE A 507
 None
 0.88A 4olbA-3qfkA:
2.9		 4olbA-3qfkA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qok PUTATIVE CHITINASE
II

(Klebsiella
pneumoniae) 		PF00704
(Glyco_hydro_18) 		3 VAL A 194
ALA A 196
PHE A 154
 None
 0.77A 4olbA-3qokA:
2.1		 4olbA-3qokA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		3 VAL A 735
ALA A 484
PHE A 502
 None
 0.91A 4olbA-3qxmA:
undetectable		 4olbA-3qxmA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sf6 GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 VAL A  88
ALA A 314
PHE A 259
 None
 0.75A 4olbA-3sf6A:
undetectable		 4olbA-3sf6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sse 5-METHYLCYTOSINE-SPE
CIFIC RESTRICTION
ENZYME B

(Escherichia
coli) 		PF12102
(DUF3578) 		3 VAL A  77
ALA A 123
PHE A 137
 None
 0.88A 4olbA-3sseA:
undetectable		 4olbA-3sseA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swo GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 VAL A  85
ALA A 311
PHE A 256
 None
 0.71A 4olbA-3swoA:
undetectable		 4olbA-3swoA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uem PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		3 VAL A 388
ALA A 448
PHE A 445
 None
 0.68A 4olbA-3uemA:
undetectable		 4olbA-3uemA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulk KETOL-ACID
REDUCTOISOMERASE

(Escherichia
coli) 		PF01450
(IlvC)
PF07991
(IlvN) 		3 VAL A 205
ALA A 203
PHE A  22
 VAL  A 205 ( 0.6A)
ALA  A 203 ( 0.0A)
PHE  A  22 ( 1.3A)
 0.84A 4olbA-3ulkA:
undetectable		 4olbA-3ulkA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1s AUTOPHAGY PROTEIN 5

(Saccharomyces
cerevisiae) 		PF04106
(APG5) 		3 VAL A  46
ALA A 134
PHE A  74
 None
 0.77A 4olbA-3w1sA:
undetectable		 4olbA-3w1sA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3s TYPE-2 SERINE--TRNA
LIGASE

(Methanopyrus
kandleri) 		PF00587
(tRNA-synt_2b) 		3 VAL A 370
ALA A 479
PHE A 242
 None
 0.89A 4olbA-3w3sA:
undetectable		 4olbA-3w3sA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrv TM-1 PROTEIN

(Solanum
lycopersicum) 		PF06792
(UPF0261) 		3 VAL A 119
ALA A 117
PHE A 191
 None
 0.70A 4olbA-3wrvA:
3.9		 4olbA-3wrvA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wry TM-1 PROTEIN

(Solanum
lycopersicum) 		PF06792
(UPF0261) 		3 VAL A 119
ALA A 117
PHE A 191
 None
 0.64A 4olbA-3wryA:
3.8		 4olbA-3wryA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdp NUCLEOCAPSID PROTEIN

(Influenza A
virus) 		PF00506
(Flu_NP) 		3 VAL A 414
ALA A 416
PHE A 458
 None
 0.85A 4olbA-3zdpA:
undetectable		 4olbA-3zdpA:
20.00