SIMILAR PATTERNS OF AMINO ACIDS FOR 4OLA_A_IPHA901

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0n PROTEIN (CSDB
PROTEIN)

(Escherichia
coli) 		PF00266
(Aminotran_5) 		4 TYR A 385
LEU A 309
GLU A 306
TYR A 305
 None
 1.29A 4olaA-1c0nA:
0.0		 4olaA-1c0nA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1k BPT4 GENE 59
HELICASE ASSEMBLY
PROTEIN

(Escherichia
virus T4) 		PF08993
(T4_Gp59_N)
PF08994
(T4_Gp59_C) 		4 TYR A  13
LEU A  71
GLU A  70
TYR A  66
 None
 1.37A 4olaA-1c1kA:
undetectable		 4olaA-1c1kA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 TYR B 545
LYS B 544
LEU B 667
GLU B 671
 None
 1.39A 4olaA-1gl9B:
4.0		 4olaA-1gl9B:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 TYR A  36
LYS A 351
LEU A  43
GLU A 298
 None
None
PG4  A9011 (-4.5A)
None
 1.50A 4olaA-1h17A:
1.1		 4olaA-1h17A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II

(Saccharomyces
cerevisiae) 		PF00150
(Cellulase) 		4 TYR A 220
LYS A 214
LEU A 156
GLU A 153
 None
 1.42A 4olaA-1h4pA:
0.0		 4olaA-1h4pA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inl SPERMIDINE SYNTHASE

(Thermotoga
maritima) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 TYR A 239
LEU A  30
GLU A  21
TYR A  23
 None
 1.33A 4olaA-1inlA:
undetectable		 4olaA-1inlA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miq PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		4 LYS A 308
LEU A 268
GLU A 269
TYR A 272
 None
 1.47A 4olaA-1miqA:
0.0		 4olaA-1miqA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2

(Homo sapiens) 		PF00051
(Kringle) 		4 TYR A   2
LYS A  59
GLU A  17
TYR A  74
 None
 1.49A 4olaA-1pmlA:
undetectable		 4olaA-1pmlA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE LARGE
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 LYS A 174
LEU A 166
GLU A 167
TYR A 151
 None
 1.35A 4olaA-2b24A:
undetectable		 4olaA-2b24A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		4 LYS A 215
LEU A  34
GLU A  33
TYR A   4
 None
 1.33A 4olaA-2eq5A:
3.6		 4olaA-2eq5A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B

(Saccharomyces
cerevisiae) 		PF16846
(Cep3) 		4 TYR A 105
LEU A 192
GLU A 190
TYR A 191
 None
 1.26A 4olaA-2quqA:
0.0		 4olaA-2quqA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r66 GLYCOSYL
TRANSFERASE, GROUP 1

(Halothermothrix
orenii) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 TYR A 250
LYS A 246
LEU A 342
GLU A 347
 None
 1.37A 4olaA-2r66A:
3.1		 4olaA-2r66A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za8 FERRITIN LIGHT CHAIN

(Equus caballus) 		PF00210
(Ferritin) 		4 TYR A  24
LYS A  59
LEU A 103
GLU A 104
 None
 0.97A 4olaA-2za8A:
undetectable		 4olaA-2za8A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqb RIBONUCLEASE HI

(Shewanella
oneidensis) 		PF00075
(RNase_H) 		4 TYR A  30
LYS A   5
LEU A  61
GLU A  63
 None
 1.21A 4olaA-2zqbA:
5.9		 4olaA-2zqbA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA

(Candida
albicans) 		PF01239
(PPTA) 		4 TYR A   6
LYS A   5
LEU A  58
GLU A  57
 None
 1.45A 4olaA-3draA:
undetectable		 4olaA-3draA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 TYR A 425
LEU A 207
GLU A 211
TYR A 208
 None
 1.10A 4olaA-3glqA:
undetectable		 4olaA-3glqA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qs1 PLASMEPSIN-1

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 LYS A 308
LEU A 269
GLU A 270
TYR A 273
 None
 1.48A 4olaA-3qs1A:
undetectable		 4olaA-3qs1A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		4 TYR A 224
LEU A 232
GLU A 235
TYR A 203
 None
 1.49A 4olaA-3s1sA:
3.6		 4olaA-3s1sA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w77 FMN-DEPENDENT
NADH-AZOREDUCTASE

(Bacillus sp.
B29) 		PF02525
(Flavodoxin_2) 		4 LYS A   8
LEU A  27
GLU A  24
TYR A  23
 None
 1.49A 4olaA-3w77A:
2.1		 4olaA-3w77A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2i LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF06431
(Polyoma_lg_T_C) 		4 TYR A 406
LYS A 410
LEU A 361
GLU A 358
 None
 1.09A 4olaA-4e2iA:
undetectable		 4olaA-4e2iA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		4 TYR A 413
LYS A 416
LEU A 356
GLU A 358
 None
 1.14A 4olaA-4i2wA:
undetectable		 4olaA-4i2wA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LYS A 610
LEU A 741
GLU A 716
TYR A 715
 None
 1.30A 4olaA-4on9A:
undetectable		 4olaA-4on9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3q 17 KDA LIPOPROTEIN

(Treponema
pallidum) 		PF04170
(NlpE) 		4 TYR A  67
LYS A  51
LEU A  81
GLU A  96
 None
 1.44A 4olaA-4u3qA:
undetectable		 4olaA-4u3qA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ulx LPBCA-L89K
THIOREDOXIN

(synthetic
construct) 		PF00085
(Thioredoxin) 		4 LYS A  99
LEU A  44
GLU A  47
TYR A  48
 None
 1.20A 4olaA-4ulxA:
undetectable		 4olaA-4ulxA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		4 TYR A 368
LYS A  77
LEU A  81
GLU A  93
 None
 1.34A 4olaA-5gu6A:
2.1		 4olaA-5gu6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izw PLS9-PPR

(unidentified) 		PF12854
(PPR_1)
PF13041
(PPR_2) 		4 LYS A  64
LEU A  94
GLU A  97
TYR A  89
 None
 1.46A 4olaA-5izwA:
undetectable		 4olaA-5izwA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lg8 FERRITIN LIGHT CHAIN

(Homo sapiens) 		PF00210
(Ferritin) 		4 TYR A  27
LYS A  62
LEU A 106
GLU A 107
 None
 0.99A 4olaA-5lg8A:
undetectable		 4olaA-5lg8A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 TYR A1193
LYS A1197
LEU A1173
GLU A1174
 None
 1.25A 4olaA-5m5pA:
1.0		 4olaA-5m5pA:
18.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 5 TYR A 655
LYS A 661
LEU A 695
GLU A 696
TYR A 699
 None
 0.88A 4olaA-5vm9A:
56.5		 4olaA-5vm9A:
79.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 LYS A 660
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 1.06A 4olaA-5weaA:
61.6		 4olaA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 TYR A 654
LEU A 694
GLU A 695
TYR A 698
 None
IPH  A 901 (-3.9A)
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.46A 4olaA-5weaA:
61.6		 4olaA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 LYS A  48
LEU A 132
GLU A 135
TYR A 137
 None
 1.24A 4olaA-5wu7A:
undetectable		 4olaA-5wu7A:
21.22