SIMILAR PATTERNS OF AMINO ACIDS FOR 4OKX_A_198A1002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtk PORPHOBILINOGEN
DEAMINASE

(Escherichia
coli) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		5 LEU A  95
GLY A  94
LEU A  70
VAL A  79
THR A 212
 None
 1.43A 4okxA-1gtkA:
undetectable		 4okxA-1gtkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		5 GLY A  11
LEU A 291
MET A 285
ARG A 218
THR A   8
 NAP  A1328 (-3.1A)
None
None
NAP  A1328 (-3.0A)
None
 1.47A 4okxA-1gveA:
0.2		 4okxA-1gveA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjq BETA-1,4-GALACTANASE

(Humicola
insolens) 		PF07745
(Glyco_hydro_53) 		5 LEU A 179
GLN A 188
LEU A 230
MET A 233
VAL A 291
 None
 1.47A 4okxA-1hjqA:
undetectable		 4okxA-1hjqA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hju BETA-1,4-GALACTANASE

(Thermothelomyces
thermophila) 		PF07745
(Glyco_hydro_53) 		5 LEU A 179
GLN A 188
LEU A 230
MET A 233
VAL A 291
 None
 1.44A 4okxA-1hjuA:
undetectable		 4okxA-1hjuA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1i META CLEAVAGE
COMPOUND HYDROLASE

(Janthinobacterium) 		PF12697
(Abhydrolase_6) 		5 LEU A  95
GLY A 120
LEU A 134
VAL A  39
VAL A 228
 None
 1.31A 4okxA-1j1iA:
undetectable		 4okxA-1j1iA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 LEU A  64
GLY A  63
LEU A 305
MET A 142
VAL A 144
 None
 1.47A 4okxA-1jftA:
undetectable		 4okxA-1jftA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4q GLUTATHIONE
REDUCTASE

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 346
GLN A 319
LEU A 153
VAL A 332
VAL A  48
 None
 1.17A 4okxA-1k4qA:
undetectable		 4okxA-1k4qA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og0 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Saccharomyces
cerevisiae) 		PF00793
(DAHP_synth_1) 		5 LEU A  70
GLY A 312
LEU A 357
VAL A  73
VAL A 295
 None
 1.44A 4okxA-1og0A:
0.0		 4okxA-1og0A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1m HYPOTHETICAL PROTEIN
TM0936

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		5 GLY A 110
LEU A 289
THR A 371
MET A 103
VAL A 368
 None
 1.44A 4okxA-1p1mA:
undetectable		 4okxA-1p1mA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)

(Solanum
tuberosum) 		PF00834
(Ribul_P_3_epim) 		5 GLY A 152
MET A  45
VAL A  44
HIS A  41
VAL A 205
 None
 1.38A 4okxA-1rpxA:
undetectable		 4okxA-1rpxA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)

(Solanum
tuberosum) 		PF00834
(Ribul_P_3_epim) 		5 GLY A 152
MET A  76
VAL A  44
HIS A  41
VAL A 205
 None
 1.16A 4okxA-1rpxA:
undetectable		 4okxA-1rpxA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 GLN B 113
LEU B  76
MET B  60
THR B  91
MET B  95
 None
 1.25A 4okxA-1skyB:
undetectable		 4okxA-1skyB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		5 LEU A  22
GLY A  96
MET A 115
VAL A 113
THR A 226
 None
 1.22A 4okxA-1tqhA:
undetectable		 4okxA-1tqhA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00834
(Ribul_P_3_epim) 		5 GLY A 150
MET A  72
VAL A  39
HIS A  36
VAL A 199
 None
None
None
ZN  A 900 (-3.4A)
None
 1.18A 4okxA-1tqxA:
undetectable		 4okxA-1tqxA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6m GALACTOSE-BINDING
LECTIN

(Arachis
hypogaea) 		PF00139
(Lectin_legB) 		5 LEU A  47
GLY A 205
VAL A 118
THR A  67
VAL A 163
 None
 1.41A 4okxA-1v6mA:
undetectable		 4okxA-1v6mA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgg CONSERVED
HYPOTHETICAL PROTEIN
TT1634 (TTHA1091)

(Thermus
thermophilus) 		PF04008
(Adenosine_kin) 		5 LEU A  14
GLY A  87
VAL A  66
HIS A  31
VAL A  35
 None
 1.29A 4okxA-1vggA:
undetectable		 4okxA-1vggA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz8 ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		5 LEU A 120
GLY A 119
LEU A  96
MET A  34
VAL A  89
 None
 1.18A 4okxA-1wz8A:
undetectable		 4okxA-1wz8A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 163
GLY A 162
THR A 135
MET A 224
VAL A 269
 None
CL  A 816 (-3.3A)
NAP  A 801 (-3.0A)
NAP  A 801 ( 4.0A)
NAP  A 801 (-4.7A)
 1.45A 4okxA-1yb5A:
undetectable		 4okxA-1yb5A:
19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 707
GLY A 708
GLN A 711
MET A 742
MET A 745
VAL A 746
ARG A 752
HIS A 874
THR A 877
MET A 895
VAL A 903
 BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.6A)
BHM  A   1 (-3.8A)
None
BHM  A   1 (-3.0A)
None
None
 0.29A 4okxA-2ax9A:
41.7		 4okxA-2ax9A:
99.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cje DUTPASE

(Leishmania
major) 		PF08761
(dUTPase_2) 		5 LEU A  24
GLN A  21
LEU A  17
VAL A  78
VAL A 221
 DUN  A1266 (-4.4A)
DUN  A1266 (-3.6A)
None
None
None
 1.40A 4okxA-2cjeA:
undetectable		 4okxA-2cjeA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cq1 PTB-LIKE PROTEIN L

(Homo sapiens) 		no annotation 5 LEU A  78
GLY A  79
LEU A 101
MET A 110
VAL A 111
 None
 1.35A 4okxA-2cq1A:
undetectable		 4okxA-2cq1A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		5 LEU A 186
LEU A 194
MET A 128
VAL A 125
HIS A 168
 None
 1.16A 4okxA-2cybA:
undetectable		 4okxA-2cybA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 LEU A 281
GLY A 280
VAL A 273
ARG A 363
THR A  95
 None
 1.01A 4okxA-2de2A:
undetectable		 4okxA-2de2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiy PROTEIN FDHE HOMOLOG

(Pseudomonas
aeruginosa) 		PF04216
(FdhE) 		5 LEU A 302
GLY A 157
GLN A 161
LEU A  55
VAL A 118
 None
 1.42A 4okxA-2fiyA:
undetectable		 4okxA-2fiyA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 171
GLY A 172
LEU A  91
VAL A  88
THR A 144
 None
 1.20A 4okxA-2fzwA:
undetectable		 4okxA-2fzwA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7v TLL2115 PROTEIN

(Synechococcus
elongatus) 		PF13354
(Beta-lactamase2) 		5 LEU A 177
GLY A 180
LEU A 194
MET A 232
VAL A 233
 None
 1.39A 4okxA-2j7vA:
undetectable		 4okxA-2j7vA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		5 LEU A 316
GLN A 389
MET A 247
THR A 280
VAL A 327
 None
 1.40A 4okxA-2nyfA:
undetectable		 4okxA-2nyfA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C

(Saccharomyces
cerevisiae) 		PF16796
(Microtub_bd) 		5 GLN A 384
MET A 382
VAL A 381
HIS A 453
THR A 451
 None
None
None
EDO  A 700 (-3.8A)
None
 1.46A 4okxA-2o0aA:
undetectable		 4okxA-2o0aA:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
 1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.8A)
 0.33A 4okxA-2q3yA:
37.1		 4okxA-2q3yA:
59.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmj DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
xylosoxidans) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		5 GLY A  64
LEU A  67
HIS A  20
MET A  37
VAL A  11
 None
 1.45A 4okxA-2vmjA:
undetectable		 4okxA-2vmjA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb1 DNA-DIRECTED RNA
POLYMERASERPO3
SUBUNIT

(Sulfolobus
shibatae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		5 LEU D 173
GLY D 215
LEU D 210
VAL D 170
VAL D 182
 None
 1.45A 4okxA-2wb1D:
undetectable		 4okxA-2wb1D:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x50 TRYPANOTHIONE
REDUCTASE

(Leishmania
infantum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 342
LEU A 157
VAL A 328
ARG A 331
VAL A  33
 None
 1.19A 4okxA-2x50A:
undetectable		 4okxA-2x50A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE

(Nocardia
farcinica) 		no annotation 5 LEU A  73
GLY A 221
LEU A  24
MET A  21
VAL A 203
 None
 1.46A 4okxA-2xecA:
undetectable		 4okxA-2xecA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 LEU A 250
GLY A 249
VAL A 214
MET A 273
VAL A 418
 None
 1.41A 4okxA-2xr1A:
undetectable		 4okxA-2xr1A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsz RUVB-LIKE 1

(Homo sapiens) 		PF06068
(TIP49) 		5 LEU A  93
GLY A  89
GLN A  56
VAL A  54
VAL A 318
 None
ATP  A 501 (-3.2A)
None
ATP  A 501 (-4.2A)
None
 1.33A 4okxA-2xszA:
undetectable		 4okxA-2xszA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		5 LEU B 179
MET B 182
VAL B 258
THR B 253
VAL B 154
 None
 1.34A 4okxA-3aeqB:
undetectable		 4okxA-3aeqB:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dd6 RIBONUCLEASE PH

(Bacillus
anthracis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 107
LEU A  98
MET A 137
VAL A 138
VAL A 199
 None
 1.47A 4okxA-3dd6A:
undetectable		 4okxA-3dd6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 GLY A  58
GLN A  59
ARG A  43
THR A 244
VAL A 274
 None
 1.37A 4okxA-3fhhA:
undetectable		 4okxA-3fhhA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		PF11715
(Nup160) 		5 GLN A 299
LEU A 243
MET A 259
VAL A 260
VAL A 223
 None
 1.28A 4okxA-3h7nA:
undetectable		 4okxA-3h7nA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 LEU A 142
MET A 357
VAL A 358
THR A 442
MET A 175
 None
 1.26A 4okxA-3hpaA:
undetectable		 4okxA-3hpaA:
18.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 721
GLY A 722
GLN A 725
MET A 756
MET A 759
VAL A 760
ARG A 766
HIS A 888
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
None
 0.70A 4okxA-3kbaA:
34.5		 4okxA-3kbaA:
54.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 721
GLY A 722
MET A 756
MET A 759
VAL A 760
ARG A 766
HIS A 888
MET A 909
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
None
None
 1.11A 4okxA-3kbaA:
34.5		 4okxA-3kbaA:
54.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9w GTPASE ERA

(Aquifex
aeolicus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		5 LEU A 179
LEU A  43
VAL A   6
MET A 184
VAL A  28
 None
 1.39A 4okxA-3r9wA:
undetectable		 4okxA-3r9wA:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		6 LEU A  35
GLY A  36
GLN A  39
MET A  70
MET A  73
ARG A  80
 1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
 0.54A 4okxA-3ry9A:
36.5		 4okxA-3ry9A:
54.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2g ZINC-CONTAINING
ALCOHOL
DEHYDROGENASE
SUPERFAMILY

(Cupriavidus
pinatubonensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 136
LEU A 151
VAL A 290
HIS A  65
THR A 116
 None
None
FU2  A 600 (-4.4A)
ZN  A 500 ( 3.3A)
None
 1.31A 4okxA-3s2gA:
undetectable		 4okxA-3s2gA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 1
H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4

(Saccharomyces
cerevisiae) 		PF01472
(PUA)
PF01509
(TruB_N)
PF04410
(Gar1)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		5 LEU A 150
GLY C  83
LEU A 206
MET A 205
VAL A 201
 None
 1.19A 4okxA-3uaiA:
undetectable		 4okxA-3uaiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhn PA_0080

(Pseudomonas
aeruginosa) 		PF12790
(T6SS-SciN) 		5 LEU A 121
LEU A  37
VAL A 110
THR A  90
VAL A  67
 None
None
IOD  A1147 ( 4.3A)
None
None
 1.46A 4okxA-3zhnA:
undetectable		 4okxA-3zhnA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bma UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Aspergillus
fumigatus) 		PF01704
(UDPGP) 		5 GLY A 251
GLN A 408
VAL A 413
HIS A 359
THR A 275
 None
 1.26A 4okxA-4bmaA:
undetectable		 4okxA-4bmaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwe GLYPICAN-1

(Homo sapiens) 		PF01153
(Glypican) 		5 LEU A 227
GLY A 226
LEU A 467
MET A 297
VAL A 298
 None
 1.33A 4okxA-4bweA:
undetectable		 4okxA-4bweA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c23 L-FUCULOSE KINASE
FUCK

(Streptococcus
pneumoniae) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A  83
GLY A  82
VAL A  79
ARG A 101
THR A 169
 None
 1.46A 4okxA-4c23A:
undetectable		 4okxA-4c23A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 LEU A 631
GLY A 630
LEU A 653
VAL A 469
THR A 647
 None
 1.16A 4okxA-4c51A:
undetectable		 4okxA-4c51A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli) 		PF05175
(MTS) 		5 LEU A 244
GLY A 243
LEU A 224
MET A 221
VAL A 339
 None
 1.31A 4okxA-4dcmA:
undetectable		 4okxA-4dcmA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6a BH1408 PROTEIN

(Bacillus
halodurans) 		PF00583
(Acetyltransf_1) 		5 LEU A 108
GLY A 106
LEU A  94
VAL A  58
VAL A  21
 None
UNL  A 501 ( 3.5A)
None
None
None
 1.22A 4okxA-4f6aA:
undetectable		 4okxA-4f6aA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 GLN B1528
MET B1664
MET B1705
THR B1572
VAL B1645
 None
 1.36A 4okxA-4f92B:
undetectable		 4okxA-4f92B:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		5 GLY A 361
GLN A 362
LEU A 244
MET A 240
VAL A 239
 None
 1.41A 4okxA-4fixA:
undetectable		 4okxA-4fixA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		5 LEU A 587
GLY A 586
LEU A 290
HIS A 283
THR A 310
 None
 1.45A 4okxA-4hhrA:
undetectable		 4okxA-4hhrA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU E 568
GLY E 569
VAL E 606
THR E 640
VAL E 665
 None
 1.21A 4okxA-4iw4E:
undetectable		 4okxA-4iw4E:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4juu EPIMERASE

(Xanthomonas
campestris) 		PF05544
(Pro_racemase) 		5 LEU A  65
GLY A  75
VAL A 116
THR A  92
VAL A 121
 PO4  A 402 ( 4.7A)
None
None
None
None
 1.12A 4okxA-4juuA:
undetectable		 4okxA-4juuA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krr WNT INHIBITOR OF
DORSAL PROTEIN

(Drosophila
melanogaster) 		PF00110
(wnt) 		5 LEU A 129
GLY A 151
GLN A 155
HIS A 145
VAL A 223
 None
 1.44A 4okxA-4krrA:
undetectable		 4okxA-4krrA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 219
GLY A 216
MET A 277
VAL A 281
HIS A 145
 None
 1.02A 4okxA-4l52A:
undetectable		 4okxA-4l52A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 LEU A  74
GLY A  75
LEU A 104
VAL A 123
VAL A  38
 None
SAM  A 301 (-3.5A)
None
None
None
 1.03A 4okxA-4lg1A:
undetectable		 4okxA-4lg1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 LEU A 398
GLY A 397
LEU A 363
MET A 465
VAL A 463
 None
 0.99A 4okxA-4n78A:
undetectable		 4okxA-4n78A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 LEU A 398
GLY A 397
MET A 465
VAL A 463
HIS A 356
 None
 1.30A 4okxA-4n78A:
undetectable		 4okxA-4n78A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 GLY A 242
LEU A 240
MET A 170
VAL A 167
HIS A 194
 None
 1.46A 4okxA-4ox2A:
undetectable		 4okxA-4ox2A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5w CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2,CALCIUM-BIND
ING MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2

(Homo sapiens) 		no annotation 5 LEU A 272
MET A 285
VAL A 249
MET A 230
VAL A 264
 None
 1.06A 4okxA-4p5wA:
undetectable		 4okxA-4p5wA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5w CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2,CALCIUM-BIND
ING MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2

(Homo sapiens) 		no annotation 5 LEU A 287
LEU A 272
VAL A 249
MET A 230
VAL A 264
 None
 1.35A 4okxA-4p5wA:
undetectable		 4okxA-4p5wA:
18.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 566
GLY A 567
GLN A 570
MET A 601
MET A 604
ARG A 611
 MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.2A)
 0.86A 4okxA-4p6wA:
32.5		 4okxA-4p6wA:
50.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1q ADHESIN/INVASIN TIBA
AUTOTRANSPORTER

(Escherichia
coli) 		PF16168
(AIDA) 		5 LEU A 217
GLN A 223
LEU A 244
THR A 271
VAL A 287
 None
 1.36A 4okxA-4q1qA:
undetectable		 4okxA-4q1qA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 LEU A 527
GLY A 525
VAL A 441
HIS A 594
MET A 573
 None
 1.27A 4okxA-4ra4A:
undetectable		 4okxA-4ra4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Rhizobium etli) 		PF01547
(SBP_bac_1) 		5 LEU A 223
GLN A 204
VAL A 394
THR A 407
MET A 403
 None
 1.31A 4okxA-4rk2A:
undetectable		 4okxA-4rk2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei) 		PF00067
(p450) 		5 LEU A 348
GLY A 351
GLN A 352
HIS A  95
VAL A  87
 None
HEM  A 501 (-4.2A)
None
HEM  A 501 (-3.8A)
HEM  A 501 (-3.8A)
 1.38A 4okxA-4tpnA:
undetectable		 4okxA-4tpnA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u36 SEED LECTIN

(Vatairea
macrocarpa) 		PF00139
(Lectin_legB) 		5 LEU A  51
GLY A 206
VAL A 120
THR A  71
VAL A 163
 None
 1.32A 4okxA-4u36A:
undetectable		 4okxA-4u36A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 GLY A 288
LEU A 267
VAL A 283
HIS A 265
VAL A 261
 None
 1.42A 4okxA-4wd1A:
undetectable		 4okxA-4wd1A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wut ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		5 GLY A  61
GLN A  60
MET A  74
VAL A  75
ARG A  81
 None
 1.45A 4okxA-4wutA:
undetectable		 4okxA-4wutA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ycr TELLURITE RESISTANCE
PROTEIN TEHA HOMOLOG

(Haemophilus
influenzae) 		PF03595
(SLAC1) 		5 LEU A 297
GLY A 296
LEU A  23
VAL A 289
VAL A  40
 None
 1.30A 4okxA-4ycrA:
undetectable		 4okxA-4ycrA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zem TRANSLATION
INITIATION FACTOR
EIF2B-LIKE
PROTEIN,TRANSLATION
INITIATION FACTOR
EIF2B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01008
(IF-2B) 		5 LEU A 197
GLY A  47
GLN A  51
LEU A  12
ARG A  20
 None
 1.43A 4okxA-4zemA:
undetectable		 4okxA-4zemA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE

(Helicobacter
pylori) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A 441
LEU A 408
MET A 384
THR A 369
VAL A 373
 None
 1.47A 4okxA-4zi6A:
undetectable		 4okxA-4zi6A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c54 DIHYDRODIPICOLINATE
SYNTHASE/N-ACETYLNEU
RAMINATE LYASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		5 LEU A 268
GLY A 267
LEU A 293
HIS A 260
THR A 258
 None
GOL  A 401 (-3.2A)
None
None
None
 1.39A 4okxA-5c54A:
undetectable		 4okxA-5c54A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.16A 4okxA-5d6nA:
undetectable		 4okxA-5d6nA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.09A 4okxA-5ey8A:
undetectable		 4okxA-5ey8A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32

(Mycobacterium
marinum) 		PF00501
(AMP-binding) 		5 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.23A 4okxA-5ey9A:
undetectable		 4okxA-5ey9A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmt FLAGELLAR ASSOCIATED
PROTEIN

(Chlamydomonas
reinhardtii) 		PF10243
(MIP-T3) 		5 LEU A  54
LEU A 113
VAL A  85
THR A  48
VAL A  18
 None
None
SO4  A1131 ( 4.8A)
None
None
 1.14A 4okxA-5fmtA:
undetectable		 4okxA-5fmtA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH) 		5 GLY A1305
GLN A1306
LEU A1586
VAL A1301
THR A1527
 None
None
None
None
SO4  A1704 (-4.0A)
 1.42A 4okxA-5gutA:
undetectable		 4okxA-5gutA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1k GEM-ASSOCIATED
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 LEU A  81
LEU A  60
VAL A 101
HIS A  63
VAL A  67
 None
 1.37A 4okxA-5h1kA:
undetectable		 4okxA-5h1kA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA

(Caldalkalibacillus
thermarum) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 GLN A 113
LEU A  76
MET A  60
THR A  91
MET A  95
 None
 1.41A 4okxA-5ik2A:
undetectable		 4okxA-5ik2A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Bacillus cereus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 GLY A 124
LEU A 133
ARG A 215
THR A  96
MET A  12
 NAD  A 401 ( 3.5A)
None
None
NAD  A 401 (-4.0A)
NAD  A 401 (-3.5A)
 1.40A 4okxA-5je8A:
undetectable		 4okxA-5je8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kaf PHOTOSYSTEM II
REACTION CENTER
PROTEIN Z

(Thermosynechococcus
elongatus) 		PF01737
(Ycf9) 		5 GLY Z  43
LEU Z  15
MET Z  19
VAL Z  20
VAL Z  51
 None
 1.14A 4okxA-5kafZ:
undetectable		 4okxA-5kafZ:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		5 LEU A 638
GLY A 637
LEU A 660
VAL A 477
THR A 654
 None
 1.06A 4okxA-5kqiA:
undetectable		 4okxA-5kqiA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxb WISTERIA FLORIBUNDA
AGGLUTININ

(Wisteria
floribunda) 		PF00139
(Lectin_legB) 		5 LEU A  81
GLY A 238
VAL A 152
THR A 101
VAL A 195
 None
 1.38A 4okxA-5kxbA:
undetectable		 4okxA-5kxbA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l25 BORON TRANSPORTER 1

(Arabidopsis
thaliana) 		PF00955
(HCO3_cotransp) 		5 LEU A 158
LEU A 555
ARG A 581
THR A 561
MET A 165
 None
 1.38A 4okxA-5l25A:
undetectable		 4okxA-5l25A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		5 LEU A 464
GLY A 444
LEU A 420
THR A 403
VAL A 385
 None
 1.38A 4okxA-5n6mA:
undetectable		 4okxA-5n6mA:
19.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 GLY A 563
GLN A 566
MET A 597
MET A 600
ARG A 607
 486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
None
486  A 801 (-3.5A)
 0.72A 4okxA-5uc1A:
22.5		 4okxA-5uc1A:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  35
GLY A  36
GLN A  39
MET A  70
ARG A  80
 1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
 0.58A 4okxA-5ufsA:
34.5		 4okxA-5ufsA:
54.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  35
GLY A  36
GLN A  39
MET A  73
ARG A  80
 1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
 0.87A 4okxA-5ufsA:
34.5		 4okxA-5ufsA:
54.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 LEU A  48
GLY A  49
ARG A 156
THR A  96
VAL A 111
 None
 1.29A 4okxA-5um6A:
undetectable		 4okxA-5um6A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE

(Mus musculus) 		no annotation 5 GLY A 260
LEU A 346
ARG A 201
MET A 369
VAL A 395
 None
 1.42A 4okxA-5w7dA:
undetectable		 4okxA-5w7dA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03739
(YjgP_YjgQ) 		5 LEU G 285
LEU G 107
MET G 106
MET G 103
VAL G 102
 None
 1.41A 4okxA-5x5yG:
undetectable		 4okxA-5x5yG:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus) 		no annotation 5 LEU A  15
GLY A  10
VAL A  29
ARG A 109
VAL A 156
 None
FAD  A 501 ( 4.9A)
None
None
None
 1.36A 4okxA-5xgvA:
undetectable		 4okxA-5xgvA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 5 GLN A 407
LEU A 380
MET A 384
ARG A 399
MET A 302
 None
 1.23A 4okxA-5y6rA:
undetectable		 4okxA-5y6rA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzg PROTEIN ZIP2
SPORULATION-SPECIFIC
PROTEIN 16

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B 654
GLY B 655
MET A 151
VAL A 149
THR B 689
 None
 1.35A 4okxA-6bzgB:
undetectable		 4okxA-6bzgB:
14.62