SIMILAR PATTERNS OF AMINO ACIDS FOR 4OKT_A_198A1001_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyv CALCIUM CHANNEL
BETA-4SUBUNIT

(Rattus
norvegicus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		4 ASN A 381
MET A 237
LEU A 378
HIS A 332
 None
 1.15A 4oktA-1vyvA:
0.0		 4oktA-1vyvA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ASN A 705
MET A 745
LEU A 873
HIS A 874
 BHM  A   1 (-3.6A)
BHM  A   1 (-3.9A)
BHM  A   1 (-4.4A)
None
 0.30A 4oktA-2ax9A:
41.6		 4oktA-2ax9A:
99.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ASN A 719
MET A 759
LEU A 887
HIS A 888
 WOW  A   1 (-3.3A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.0A)
None
 0.84A 4oktA-3kbaA:
34.5		 4oktA-3kbaA:
54.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kom TRANSKETOLASE

(Francisella
tularensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ASN A  91
MET A  71
LEU A  84
HIS A  78
 None
 1.31A 4oktA-3komA:
0.0		 4oktA-3komA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ASN A 109
MET A  89
LEU A 102
HIS A  96
 None
 1.31A 4oktA-3uk1A:
0.0		 4oktA-3uk1A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ASN A  89
MET A  69
LEU A  82
HIS A  76
 None
 1.26A 4oktA-4xeuA:
0.0		 4oktA-4xeuA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		4 ASN A 550
MET A  83
LEU A  77
HIS A  49
 None
 1.41A 4oktA-4y23A:
0.0		 4oktA-4y23A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrb TRANSKETOLASE

(Neisseria
gonorrhoeae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ASN A  86
MET A  66
LEU A  79
HIS A  73
 None
 1.27A 4oktA-5vrbA:
0.0		 4oktA-5vrbA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 4 ASN A 224
MET A  23
LEU A 274
HIS A 326
 None
 1.23A 4oktA-6eu6A:
0.0		 4oktA-6eu6A:
14.29