SIMILAR PATTERNS OF AMINO ACIDS FOR 4OKB_A_198A1002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0i DNA LIGASE

(Escherichia
virus T7) 		PF01068
(DNA_ligase_A_M) 		5 LEU A 169
MET A 170
VAL A 174
MET A 177
ILE A 227
 None
 0.95A 4okbA-1a0iA:
undetectable		 4okbA-1a0iA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 LEU A 159
MET A 191
VAL A 190
MET A 187
ILE A 130
 None
 1.35A 4okbA-1b25A:
0.1		 4okbA-1b25A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgp ARISTOLOCHENE
SYNTHASE

(Penicillium
roqueforti) 		no annotation 5 LEU A 167
GLY A 218
LEU A  97
MET A 160
HIS A  51
 None
 1.30A 4okbA-1dgpA:
1.6		 4okbA-1dgpA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtk PORPHOBILINOGEN
DEAMINASE

(Escherichia
coli) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		5 LEU A  95
GLY A  94
LEU A  70
VAL A  79
THR A 212
 None
 1.42A 4okbA-1gtkA:
undetectable		 4okbA-1gtkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu9 ASPARTATE RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		5 GLY A 193
LEU A 121
VAL A 132
THR A 107
ILE A 211
 None
 1.35A 4okbA-1iu9A:
undetectable		 4okbA-1iu9A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka8 PUTATIVE P4-SPECIFIC
DNA PRIMASE

(Enterobacteria
phage P4) 		PF03288
(Pox_D5) 		5 LEU A  63
GLY A  60
LEU A  56
MET A  23
MET A  21
 None
 1.20A 4okbA-1ka8A:
0.0		 4okbA-1ka8A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqu ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Haemophilus
influenzae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A  30
LEU A  17
MET A  18
MET A  21
ILE A   7
 None
 1.24A 4okbA-1pquA:
0.0		 4okbA-1pquA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr7 PHENYLALANINE-REGULA
TED
3-DEOXY-D-ARABINO-HE
PTULOSONATE-7-PHOSPH
ATE SYNTHASE

(Escherichia
coli) 		PF00793
(DAHP_synth_1) 		5 GLY A 142
LEU A 130
MET A 157
THR A 149
ILE A 108
 None
 1.13A 4okbA-1qr7A:
0.0		 4okbA-1qr7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		5 GLY A 609
LEU A 605
MET A 514
VAL A 515
ILE A 591
 None
 1.38A 4okbA-1rt8A:
0.0		 4okbA-1rt8A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		5 LEU A  22
GLY A  96
MET A 115
VAL A 113
THR A 226
 None
 1.21A 4okbA-1tqhA:
0.0		 4okbA-1tqhA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF06026
(Rib_5-P_isom_A) 		5 LEU A  41
LEU A  73
VAL A  25
MET A  24
THR A  58
 None
 1.36A 4okbA-1uj4A:
undetectable		 4okbA-1uj4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5e FTSZ

(Methanocaldococcus
jannaschii) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 LEU A 131
GLY A 130
LEU A 215
VAL A 188
ILE A  53
 None
GTP  A 500 (-3.5A)
None
None
None
 1.19A 4okbA-1w5eA:
undetectable		 4okbA-1w5eA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmx HYPOTHETICAL PROTEIN
VC1899

(Vibrio cholerae) 		PF09002
(DUF1887) 		5 LEU A  99
GLY A  94
LEU A  15
VAL A   5
ILE A  40
 None
 1.36A 4okbA-1xmxA:
undetectable		 4okbA-1xmxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbe COAT PROTEIN VP1

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 LEU 1 126
LEU 1  76
MET 1 178
THR 1  56
ILE 1  42
 None
 1.35A 4okbA-1zbe1:
undetectable		 4okbA-1zbe1:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zo1 TRANSLATION
INITIATION FACTOR 2

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		5 LEU I 454
GLY I 466
GLN I 451
ARG I 414
ILE I 460
 None
 1.12A 4okbA-1zo1I:
undetectable		 4okbA-1zo1I:
19.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 707
GLY A 708
GLN A 711
MET A 742
MET A 745
VAL A 746
MET A 749
ARG A 752
HIS A 874
THR A 877
ILE A 899
 BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.8A)
None
BHM  A   1 (-3.0A)
None
 0.45A 4okbA-2ax9A:
41.3		 4okbA-2ax9A:
99.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cq1 PTB-LIKE PROTEIN L

(Homo sapiens) 		no annotation 5 GLY A  79
LEU A 101
MET A 110
VAL A 111
ILE A  88
 None
 1.09A 4okbA-2cq1A:
undetectable		 4okbA-2cq1A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cq1 PTB-LIKE PROTEIN L

(Homo sapiens) 		no annotation 5 LEU A  78
GLY A  79
LEU A 101
MET A 110
VAL A 111
 None
 1.29A 4okbA-2cq1A:
undetectable		 4okbA-2cq1A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		5 LEU A 186
LEU A 194
MET A 128
VAL A 125
HIS A 168
 None
 1.16A 4okbA-2cybA:
undetectable		 4okbA-2cybA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 LEU A 281
GLY A 280
VAL A 273
ARG A 363
THR A  95
 None
 1.04A 4okbA-2de2A:
undetectable		 4okbA-2de2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 171
GLY A 172
LEU A  91
VAL A  88
THR A 144
 None
 1.19A 4okbA-2fzwA:
undetectable		 4okbA-2fzwA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hor ALLIIN LYASE 1

(Allium sativum) 		PF04863
(EGF_alliinase)
PF04864
(Alliinase_C) 		5 GLY A 129
GLN A 134
LEU A 274
MET A 278
ILE A 126
 None
 0.94A 4okbA-2horA:
undetectable		 4okbA-2horA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7v TLL2115 PROTEIN

(Synechococcus
elongatus) 		PF13354
(Beta-lactamase2) 		5 LEU A 177
GLY A 180
LEU A 194
MET A 232
VAL A 233
 None
 1.39A 4okbA-2j7vA:
undetectable		 4okbA-2j7vA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nly DIVERGENT
POLYSACCHARIDE
DEACETYLASE
HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF04748
(Polysacc_deac_2) 		5 LEU A  66
GLY A  42
VAL A  85
MET A  87
ILE A  75
 None
 1.21A 4okbA-2nlyA:
undetectable		 4okbA-2nlyA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE

(Macaca
fascicularis) 		PF01408
(GFO_IDH_MocA) 		5 LEU X1177
GLY X1178
LEU X1318
ARG X1163
ILE X1185
 None
 1.26A 4okbA-2o4uX:
undetectable		 4okbA-2o4uX:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		5 LEU A 362
GLY A 361
LEU A 165
ARG A 336
ILE A 424
 None
 1.34A 4okbA-2obmA:
undetectable		 4okbA-2obmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Pseudomonas
savastanoi) 		PF01966
(HD) 		5 LEU A 235
LEU A 330
VAL A 315
THR A 307
ILE A 245
 None
 1.37A 4okbA-2pgsA:
undetectable		 4okbA-2pgsA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psy KALLIKREIN-5

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU A 155
GLY A 140
GLN A  30
VAL A 199
ILE A  17
 None
 1.28A 4okbA-2psyA:
undetectable		 4okbA-2psyA:
23.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
ILE A 227
 1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.8A)
None
 0.57A 4okbA-2q3yA:
36.8		 4okbA-2q3yA:
59.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2var FRUCTOKINASE

(Sulfolobus
solfataricus) 		PF00294
(PfkB) 		5 LEU A  11
GLY A  34
LEU A  52
VAL A  56
ILE A  41
 KDG  A1313 ( 4.7A)
KDG  A1313 ( 3.3A)
None
None
None
 1.28A 4okbA-2varA:
undetectable		 4okbA-2varA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		5 LEU A1876
GLY A1875
HIS A1530
THR A1624
ILE A1871
 None
 1.25A 4okbA-2vz9A:
undetectable		 4okbA-2vz9A:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		5 LEU A 403
LEU A 268
MET A 269
VAL A 273
ILE A 413
 None
 1.03A 4okbA-2wsxA:
undetectable		 4okbA-2wsxA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4

(Homo sapiens) 		PF00443
(UCH) 		5 LEU A 301
GLY A 300
GLN A 298
THR A 327
ILE A 359
 None
 1.41A 4okbA-2y6eA:
undetectable		 4okbA-2y6eA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ceb D-AMINOACID
AMINOTRANSFERASE-LIK
E PLP-DEPENDENT
ENZYME

(Histophilus
somni) 		PF01063
(Aminotran_4) 		5 LEU A 154
GLY A 156
ARG A 106
THR A 148
ILE A 168
 LLP  A 102 ( 4.2A)
LLP  A 102 ( 3.3A)
LLP  A 102 (-3.1A)
None
None
 1.25A 4okbA-3cebA:
undetectable		 4okbA-3cebA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehf SENSOR KINASE (YOCF
PROTEIN)

(Bacillus
subtilis) 		PF07730
(HisKA_3) 		5 LEU A 287
LEU A 344
VAL A 315
HIS A 352
ILE A 353
 None
 1.38A 4okbA-3ehfA:
undetectable		 4okbA-3ehfA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 GLY A  58
GLN A  59
ARG A  43
THR A 244
ILE A 276
 None
 1.42A 4okbA-3fhhA:
undetectable		 4okbA-3fhhA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		5 LEU A 350
GLY A 349
LEU A 335
VAL A 330
MET A 327
 None
 1.15A 4okbA-3g77A:
undetectable		 4okbA-3g77A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 LEU A 284
GLY A 285
VAL A 292
MET A 297
THR A 173
 None
None
None
None
FAD  A 902 ( 4.5A)
 1.26A 4okbA-3gsiA:
undetectable		 4okbA-3gsiA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE SMALL
FES SUBUNIT

(Eubacterium
barkeri) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		5 GLY D  67
GLN D  68
LEU D  25
THR D  19
ILE D  17
 None
 1.42A 4okbA-3hrdD:
undetectable		 4okbA-3hrdD:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3w PHOSPHOGLUCOSAMINE
MUTASE

(Francisella
tularensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 GLY A  54
GLN A  48
VAL A  46
THR A  24
ILE A  19
 None
 1.41A 4okbA-3i3wA:
undetectable		 4okbA-3i3wA:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 718
MET A 756
MET A 759
VAL A 760
HIS A 888
ILE A 913
 WOW  A   1 (-4.2A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.1A)
None
None
 1.43A 4okbA-3kbaA:
34.5		 4okbA-3kbaA:
54.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 721
GLY A 722
GLN A 725
MET A 756
MET A 759
VAL A 760
ARG A 766
HIS A 888
ILE A 913
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
None
None
 0.81A 4okbA-3kbaA:
34.5		 4okbA-3kbaA:
54.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 GLY A 429
MET A 487
VAL A 765
THR A 426
ILE A 404
 None
 1.35A 4okbA-3la4A:
undetectable		 4okbA-3la4A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2t PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00248
(Aldo_ket_red) 		5 LEU A 126
GLN A 128
LEU A 281
VAL A 205
ILE A  50
 None
 1.33A 4okbA-3n2tA:
undetectable		 4okbA-3n2tA:
21.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		7 LEU A  35
GLY A  36
GLN A  39
MET A  70
MET A  73
ARG A  80
ILE A 227
 1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
None
 0.70A 4okbA-3ry9A:
36.3		 4okbA-3ry9A:
54.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tj0 NUCLEOPROTEIN

(Influenza B
virus) 		PF00506
(Flu_NP) 		5 GLY A 247
LEU A 317
MET A 321
VAL A 322
ILE A 255
 None
 1.26A 4okbA-3tj0A:
undetectable		 4okbA-3tj0A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137

(Staphylococcus
aureus) 		PF13379
(NMT1_2) 		5 LEU A  78
GLY A  40
LEU A  50
VAL A 222
ILE A  37
 None
 1.33A 4okbA-3un6A:
undetectable		 4okbA-3un6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		5 LEU A  72
LEU A 174
MET A 135
VAL A 134
ILE A  51
 None
 1.28A 4okbA-3wjoA:
undetectable		 4okbA-3wjoA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwn ORFF

(Thermus
thermophilus) 		PF08271
(TF_Zn_Ribbon) 		5 LEU B  37
GLY B  36
LEU B  42
VAL B   2
MET B   1
 None
 1.41A 4okbA-3wwnB:
undetectable		 4okbA-3wwnB:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyz RIBONUCLEASE P
PROTEIN COMPONENT 3

(Thermococcus
kodakarensis) 		PF01876
(RNase_P_p30) 		5 GLY A  93
GLN A  92
LEU A 110
ARG A  19
THR A 162
 None
GOL  A 301 (-2.5A)
None
GOL  A 301 (-2.9A)
None
 1.40A 4okbA-3wyzA:
undetectable		 4okbA-3wyzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 GLY A 652
LEU A 812
MET A 780
VAL A 781
ILE A 670
 None
 1.30A 4okbA-3zyvA:
undetectable		 4okbA-3zyvA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		5 LEU A  80
GLY A  63
LEU A 167
VAL A  66
ILE A 157
 None
 1.34A 4okbA-4bjuA:
undetectable		 4okbA-4bjuA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btg MAJOR INNER PROTEIN
P1

(Pseudomonas
virus phi6) 		no annotation 5 LEU A 439
GLY A 440
VAL A 457
HIS A 630
ILE A 632
 None
 1.37A 4okbA-4btgA:
undetectable		 4okbA-4btgA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwe GLYPICAN-1

(Homo sapiens) 		PF01153
(Glypican) 		5 LEU A 227
GLY A 226
LEU A 467
MET A 297
VAL A 298
 None
 1.29A 4okbA-4bweA:
undetectable		 4okbA-4bweA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 LEU A 631
GLY A 630
LEU A 653
VAL A 469
THR A 647
 None
 1.12A 4okbA-4c51A:
undetectable		 4okbA-4c51A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4r PHOSPHATE
ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF01515
(PTA_PTB) 		5 GLY A  24
LEU A  56
ARG A 308
THR A  34
ILE A  64
 None
 1.32A 4okbA-4e4rA:
undetectable		 4okbA-4e4rA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee1 DNA PRIMASE

(Staphylococcus
aureus) 		PF08275
(Toprim_N)
PF13155
(Toprim_2) 		5 LEU A 245
VAL A 283
ARG A 156
HIS A 294
THR A 288
 None
 1.36A 4okbA-4ee1A:
undetectable		 4okbA-4ee1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eud SUCCINYL-COA:ACETATE
COENZYME A
TRANSFERASE

(Acetobacter
aceti) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 LEU A 266
GLY A 291
LEU A 304
MET A 309
ILE A 339
 None
 1.34A 4okbA-4eudA:
undetectable		 4okbA-4eudA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezb UNCHARACTERIZED
CONSERVED PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 LEU A 190
LEU A 290
VAL A 285
THR A 226
ILE A 261
 None
 1.25A 4okbA-4ezbA:
undetectable		 4okbA-4ezbA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		5 LEU A 214
GLY A 213
MET A 174
HIS A  76
ILE A  46
 None
None
None
GOL  A 402 (-4.4A)
GOL  A 402 (-4.3A)
 1.37A 4okbA-4f62A:
3.1		 4okbA-4f62A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF12741
(SusD-like) 		5 LEU A 146
GLN A  55
VAL A 208
THR A 130
ILE A 129
 None
 1.25A 4okbA-4f7aA:
undetectable		 4okbA-4f7aA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		5 GLY A 361
GLN A 362
LEU A 244
MET A 240
VAL A 239
 None
 1.40A 4okbA-4fixA:
undetectable		 4okbA-4fixA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP1

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 LEU A 126
LEU A  76
MET A 179
THR A  56
ILE A  42
 None
 1.28A 4okbA-4gh4A:
undetectable		 4okbA-4gh4A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0n DNMT2

(Spodoptera
frugiperda) 		PF00145
(DNA_methylase) 		5 LEU A 326
LEU A  24
HIS A   3
THR A  71
ILE A   5
 None
 1.21A 4okbA-4h0nA:
undetectable		 4okbA-4h0nA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6n AMINODEOXYCHORISMATE
LYASE

(Saccharomyces
cerevisiae) 		PF01063
(Aminotran_4) 		5 LEU A 326
GLY A 328
ARG A 255
THR A 318
ILE A 340
 PLP  A 500 (-4.1A)
PLP  A 500 (-3.4A)
PLP  A 500 (-3.0A)
None
None
 1.26A 4okbA-4k6nA:
undetectable		 4okbA-4k6nA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7t NANU SIALIC ACID
BINDING PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 LEU A  46
LEU A 138
MET A 134
MET A 109
ILE A 385
 None
 1.40A 4okbA-4l7tA:
undetectable		 4okbA-4l7tA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Proteus
mirabilis) 		PF02028
(BCCT) 		5 LEU A 403
LEU A 268
MET A 269
VAL A 273
ILE A 413
 None
 0.96A 4okbA-4m8jA:
undetectable		 4okbA-4m8jA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 LEU A 398
GLY A 397
LEU A 363
MET A 465
VAL A 463
 None
 1.00A 4okbA-4n78A:
undetectable		 4okbA-4n78A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 LEU A 398
GLY A 397
MET A 465
VAL A 463
HIS A 356
 None
 1.27A 4okbA-4n78A:
undetectable		 4okbA-4n78A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2

(Homo sapiens) 		PF00254
(FKBP_C) 		5 GLY A  99
LEU A 134
MET A  54
VAL A 131
ILE A 136
 None
 1.35A 4okbA-4nnrA:
undetectable		 4okbA-4nnrA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqy ISOPROPYLMALATE/CITR
AMALATE ISOMERASE
LARGE SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		5 LEU A  46
LEU A  81
MET A  82
VAL A  86
ILE A  37
 None
 1.16A 4okbA-4nqyA:
undetectable		 4okbA-4nqyA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 GLY A 242
LEU A 240
MET A 170
VAL A 167
HIS A 194
 None
 1.41A 4okbA-4ox2A:
undetectable		 4okbA-4ox2A:
17.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 566
GLY A 567
GLN A 570
MET A 601
ARG A 611
ILE A 757
 MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
None
 0.82A 4okbA-4p6wA:
32.4		 4okbA-4p6wA:
50.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 566
GLY A 567
GLN A 570
MET A 604
ARG A 611
ILE A 757
 MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-4.2A)
None
 0.97A 4okbA-4p6wA:
32.4		 4okbA-4p6wA:
50.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 772
GLN A 776
MET A 807
ARG A 817
ILE A 964
 CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
None
 0.81A 4okbA-4udbA:
33.1		 4okbA-4udbA:
52.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utg SUGAR KINASE

(Burkholderia
pseudomallei) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A  82
LEU A 104
MET A 126
VAL A 125
THR A  60
 None
 1.40A 4okbA-4utgA:
undetectable		 4okbA-4utgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		5 GLY A 948
LEU A 951
VAL A 624
MET A 623
ARG A 274
 None
 1.30A 4okbA-4xgtA:
undetectable		 4okbA-4xgtA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by7 3-OXOACYL-ACP
SYNTHASE III

(Verrucosispora
maris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 303
GLY A 304
VAL A 260
ARG A 240
ILE A 284
 None
 1.40A 4okbA-5by7A:
undetectable		 4okbA-5by7A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chs RNA-DIRECTED RNA
POLYMERASE L

(Indiana
vesiculovirus) 		PF00946
(Mononeg_RNA_pol) 		5 GLY A 359
LEU A  99
MET A  95
MET A  91
ILE A 239
 None
 0.96A 4okbA-5chsA:
undetectable		 4okbA-5chsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.14A 4okbA-5d6nA:
undetectable		 4okbA-5d6nA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.07A 4okbA-5ey8A:
undetectable		 4okbA-5ey8A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32

(Mycobacterium
marinum) 		PF00501
(AMP-binding) 		5 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.22A 4okbA-5ey9A:
undetectable		 4okbA-5ey9A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		5 LEU A 536
GLY A 501
VAL A 497
THR A 562
ILE A 591
 None
 1.40A 4okbA-5fg3A:
undetectable		 4okbA-5fg3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Homo sapiens) 		PF00009
(GTP_EFTU) 		5 GLY A 134
LEU A  13
MET A 113
VAL A  10
ILE A 100
 None
 1.41A 4okbA-5izkA:
undetectable		 4okbA-5izkA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00171
(Aldedh) 		5 LEU A 274
GLY A 192
MET A 265
THR A 195
ILE A 204
 None
 1.36A 4okbA-5jfmA:
undetectable		 4okbA-5jfmA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		5 LEU A 638
GLY A 637
LEU A 660
VAL A 477
THR A 654
 None
 1.02A 4okbA-5kqiA:
undetectable		 4okbA-5kqiA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 772
GLN A 776
MET A 807
ARG A 817
ILE A 964
 ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
None
 0.74A 4okbA-5mwpA:
36.7		 4okbA-5mwpA:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 GLY A 563
GLN A 566
MET A 597
MET A 600
ARG A 607
 486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
None
486  A 801 (-3.5A)
 0.80A 4okbA-5uc1A:
22.5		 4okbA-5uc1A:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  35
GLY A  36
GLN A  39
MET A  70
ARG A  80
ILE A 226
 1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
None
 0.79A 4okbA-5ufsA:
34.3		 4okbA-5ufsA:
54.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  35
GLY A  36
GLN A  39
MET A  73
ARG A  80
ILE A 226
 1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
None
 0.95A 4okbA-5ufsA:
34.3		 4okbA-5ufsA:
54.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03739
(YjgP_YjgQ) 		5 LEU G 285
LEU G 107
MET G 106
MET G 103
VAL G 102
 None
 1.41A 4okbA-5x5yG:
2.1		 4okbA-5x5yG:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C

(Mycobacterium
tuberculosis) 		PF01596
(Methyltransf_3) 		5 LEU A 124
GLY A 151
LEU A 155
VAL A  62
ILE A 192
 None
 1.40A 4okbA-5x7fA:
undetectable		 4okbA-5x7fA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8g 2-SUCCINYLBENZOATE--
COA LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A  22
LEU A   9
VAL A  70
MET A  66
ILE A 208
 None
MG  A 503 ( 4.3A)
None
None
None
 1.25A 4okbA-5x8gA:
undetectable		 4okbA-5x8gA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
BETA-CATENIN-LIKE
PROTEIN HMP-2

(Caenorhabditis
elegans) 		PF01044
(Vinculin)
no annotation 		5 LEU A 126
GLY A 123
LEU B  67
VAL A  51
ILE A 118
 None
 1.35A 4okbA-5xa5A:
undetectable		 4okbA-5xa5A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu1 LYSINE
CYCLODEAMINASE

(Streptomyces
pristinaespiralis) 		no annotation 5 LEU A 117
LEU A  23
MET A  24
HIS A 155
THR A 152
 None
 1.17A 4okbA-5yu1A:
undetectable		 4okbA-5yu1A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 5 LEU A 698
GLY A 728
VAL A 644
MET A 645
ILE A 411
 None
 1.05A 4okbA-6a91A:
undetectable		 4okbA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3y DENN
DOMAIN-CONTAINING
PROTEIN 3

(Mus musculus) 		no annotation 5 LEU A 917
LEU A 885
MET A 889
VAL A 890
MET A 893
 None
 1.30A 4okbA-6b3yA:
undetectable		 4okbA-6b3yA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4o GLUTATHIONE
REDUCTASE

(Enterococcus
faecalis) 		no annotation 5 GLY A 317
GLN A 290
LEU A 135
VAL A 303
ILE A  16
 None
 1.26A 4okbA-6b4oA:
undetectable		 4okbA-6b4oA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 5 GLY A  53
LEU A 511
MET A 501
HIS A 486
ILE A  84
 None
None
None
SO4  A 608 (-4.8A)
None
 1.34A 4okbA-6byxA:
undetectable		 4okbA-6byxA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzg PROTEIN ZIP2
SPORULATION-SPECIFIC
PROTEIN 16

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B 654
GLY B 655
MET A 151
VAL A 149
THR B 689
 None
 1.35A 4okbA-6bzgB:
undetectable		 4okbA-6bzgB:
14.62