SIMILAR PATTERNS OF AMINO ACIDS FOR 4OKB_A_198A1002

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0i DNA LIGASE

(Escherichia
virus T7) 		PF01068
(DNA_ligase_A_M) 		5 LEU A 169
MET A 170
VAL A 174
MET A 177
ILE A 227
 None
 0.95A 4okbA-1a0iA:
undetectable		 4okbA-1a0iA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 LEU A 159
MET A 191
VAL A 190
MET A 187
ILE A 130
 None
 1.35A 4okbA-1b25A:
0.1		 4okbA-1b25A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgp ARISTOLOCHENE
SYNTHASE

(Penicillium
roqueforti) 		no annotation 5 LEU A 167
GLY A 218
LEU A  97
MET A 160
HIS A  51
 None
 1.30A 4okbA-1dgpA:
1.6		 4okbA-1dgpA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtk PORPHOBILINOGEN
DEAMINASE

(Escherichia
coli) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		5 LEU A  95
GLY A  94
LEU A  70
VAL A  79
THR A 212
 None
 1.42A 4okbA-1gtkA:
undetectable		 4okbA-1gtkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu9 ASPARTATE RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		5 GLY A 193
LEU A 121
VAL A 132
THR A 107
ILE A 211
 None
 1.35A 4okbA-1iu9A:
undetectable		 4okbA-1iu9A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka8 PUTATIVE P4-SPECIFIC
DNA PRIMASE

(Enterobacteria
phage P4) 		PF03288
(Pox_D5) 		5 LEU A  63
GLY A  60
LEU A  56
MET A  23
MET A  21
 None
 1.20A 4okbA-1ka8A:
0.0		 4okbA-1ka8A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqu ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Haemophilus
influenzae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A  30
LEU A  17
MET A  18
MET A  21
ILE A   7
 None
 1.24A 4okbA-1pquA:
0.0		 4okbA-1pquA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr7 PHENYLALANINE-REGULA
TED
3-DEOXY-D-ARABINO-HE
PTULOSONATE-7-PHOSPH
ATE SYNTHASE

(Escherichia
coli) 		PF00793
(DAHP_synth_1) 		5 GLY A 142
LEU A 130
MET A 157
THR A 149
ILE A 108
 None
 1.13A 4okbA-1qr7A:
0.0		 4okbA-1qr7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		5 GLY A 609
LEU A 605
MET A 514
VAL A 515
ILE A 591
 None
 1.38A 4okbA-1rt8A:
0.0		 4okbA-1rt8A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		5 LEU A  22
GLY A  96
MET A 115
VAL A 113
THR A 226
 None
 1.21A 4okbA-1tqhA:
0.0		 4okbA-1tqhA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF06026
(Rib_5-P_isom_A) 		5 LEU A  41
LEU A  73
VAL A  25
MET A  24
THR A  58
 None
 1.36A 4okbA-1uj4A:
undetectable		 4okbA-1uj4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5e FTSZ

(Methanocaldococcus
jannaschii) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 LEU A 131
GLY A 130
LEU A 215
VAL A 188
ILE A  53
 None
GTP  A 500 (-3.5A)
None
None
None
 1.19A 4okbA-1w5eA:
undetectable		 4okbA-1w5eA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmx HYPOTHETICAL PROTEIN
VC1899

(Vibrio cholerae) 		PF09002
(DUF1887) 		5 LEU A  99
GLY A  94
LEU A  15
VAL A   5
ILE A  40
 None
 1.36A 4okbA-1xmxA:
undetectable		 4okbA-1xmxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbe COAT PROTEIN VP1

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 LEU 1 126
LEU 1  76
MET 1 178
THR 1  56
ILE 1  42
 None
 1.35A 4okbA-1zbe1:
undetectable		 4okbA-1zbe1:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zo1 TRANSLATION
INITIATION FACTOR 2

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		5 LEU I 454
GLY I 466
GLN I 451
ARG I 414
ILE I 460
 None
 1.12A 4okbA-1zo1I:
undetectable		 4okbA-1zo1I:
19.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 707
GLY A 708
GLN A 711
MET A 742
MET A 745
VAL A 746
MET A 749
ARG A 752
HIS A 874
THR A 877
ILE A 899
 BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.8A)
None
BHM  A   1 (-3.0A)
None
 0.45A 4okbA-2ax9A:
41.3		 4okbA-2ax9A:
99.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cq1 PTB-LIKE PROTEIN L

(Homo sapiens) 		no annotation 5 GLY A  79
LEU A 101
MET A 110
VAL A 111
ILE A  88
 None
 1.09A 4okbA-2cq1A:
undetectable		 4okbA-2cq1A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cq1 PTB-LIKE PROTEIN L

(Homo sapiens) 		no annotation 5 LEU A  78
GLY A  79
LEU A 101
MET A 110
VAL A 111
 None
 1.29A 4okbA-2cq1A:
undetectable		 4okbA-2cq1A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		5 LEU A 186
LEU A 194
MET A 128
VAL A 125
HIS A 168
 None
 1.16A 4okbA-2cybA:
undetectable		 4okbA-2cybA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 LEU A 281
GLY A 280
VAL A 273
ARG A 363
THR A  95
 None
 1.04A 4okbA-2de2A:
undetectable		 4okbA-2de2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 171
GLY A 172
LEU A  91
VAL A  88
THR A 144
 None
 1.19A 4okbA-2fzwA:
undetectable		 4okbA-2fzwA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hor ALLIIN LYASE 1

(Allium sativum) 		PF04863
(EGF_alliinase)
PF04864
(Alliinase_C) 		5 GLY A 129
GLN A 134
LEU A 274
MET A 278
ILE A 126
 None
 0.94A 4okbA-2horA:
undetectable		 4okbA-2horA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7v TLL2115 PROTEIN

(Synechococcus
elongatus) 		PF13354
(Beta-lactamase2) 		5 LEU A 177
GLY A 180
LEU A 194
MET A 232
VAL A 233
 None
 1.39A 4okbA-2j7vA:
undetectable		 4okbA-2j7vA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nly DIVERGENT
POLYSACCHARIDE
DEACETYLASE
HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF04748
(Polysacc_deac_2) 		5 LEU A  66
GLY A  42
VAL A  85
MET A  87
ILE A  75
 None
 1.21A 4okbA-2nlyA:
undetectable		 4okbA-2nlyA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4u DIMERIC DIHYDRODIOL
DEHYDROGENASE

(Macaca
fascicularis) 		PF01408
(GFO_IDH_MocA) 		5 LEU X1177
GLY X1178
LEU X1318
ARG X1163
ILE X1185
 None
 1.26A 4okbA-2o4uX:
undetectable		 4okbA-2o4uX:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		5 LEU A 362
GLY A 361
LEU A 165
ARG A 336
ILE A 424
 None
 1.34A 4okbA-2obmA:
undetectable		 4okbA-2obmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Pseudomonas
savastanoi) 		PF01966
(HD) 		5 LEU A 235
LEU A 330
VAL A 315
THR A 307
ILE A 245
 None
 1.37A 4okbA-2pgsA:
undetectable		 4okbA-2pgsA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psy KALLIKREIN-5

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU A 155
GLY A 140
GLN A  30
VAL A 199
ILE A  17
 None
 1.28A 4okbA-2psyA:
undetectable		 4okbA-2psyA:
23.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
ILE A 227
 1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.8A)
None
 0.57A 4okbA-2q3yA:
36.8		 4okbA-2q3yA:
59.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2var FRUCTOKINASE

(Sulfolobus
solfataricus) 		PF00294
(PfkB) 		5 LEU A  11
GLY A  34
LEU A  52
VAL A  56
ILE A  41
 KDG  A1313 ( 4.7A)
KDG  A1313 ( 3.3A)
None
None
None
 1.28A 4okbA-2varA:
undetectable		 4okbA-2varA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		5 LEU A1876
GLY A1875
HIS A1530
THR A1624
ILE A1871
 None
 1.25A 4okbA-2vz9A:
undetectable		 4okbA-2vz9A:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		5 LEU A 403
LEU A 268
MET A 269
VAL A 273
ILE A 413
 None
 1.03A 4okbA-2wsxA:
undetectable		 4okbA-2wsxA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4

(Homo sapiens) 		PF00443
(UCH) 		5 LEU A 301
GLY A 300
GLN A 298
THR A 327
ILE A 359
 None
 1.41A 4okbA-2y6eA:
undetectable		 4okbA-2y6eA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ceb D-AMINOACID
AMINOTRANSFERASE-LIK
E PLP-DEPENDENT
ENZYME

(Histophilus
somni) 		PF01063
(Aminotran_4) 		5 LEU A 154
GLY A 156
ARG A 106
THR A 148
ILE A 168
 LLP  A 102 ( 4.2A)
LLP  A 102 ( 3.3A)
LLP  A 102 (-3.1A)
None
None
 1.25A 4okbA-3cebA:
undetectable		 4okbA-3cebA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehf SENSOR KINASE (YOCF
PROTEIN)

(Bacillus
subtilis) 		PF07730
(HisKA_3) 		5 LEU A 287
LEU A 344
VAL A 315
HIS A 352
ILE A 353
 None
 1.38A 4okbA-3ehfA:
undetectable		 4okbA-3ehfA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 GLY A  58
GLN A  59
ARG A  43
THR A 244
ILE A 276
 None
 1.42A 4okbA-3fhhA:
undetectable		 4okbA-3fhhA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		5 LEU A 350
GLY A 349
LEU A 335
VAL A 330
MET A 327
 None
 1.15A 4okbA-3g77A:
undetectable		 4okbA-3g77A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 LEU A 284
GLY A 285
VAL A 292
MET A 297
THR A 173
 None
None
None
None
FAD  A 902 ( 4.5A)
 1.26A 4okbA-3gsiA:
undetectable		 4okbA-3gsiA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE SMALL
FES SUBUNIT

(Eubacterium
barkeri) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		5 GLY D  67
GLN D  68
LEU D  25
THR D  19
ILE D  17
 None
 1.42A 4okbA-3hrdD:
undetectable		 4okbA-3hrdD:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3w PHOSPHOGLUCOSAMINE
MUTASE

(Francisella
tularensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 GLY A  54
GLN A  48
VAL A  46
THR A  24
ILE A  19
 None
 1.41A 4okbA-3i3wA:
undetectable		 4okbA-3i3wA:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 718
MET A 756
MET A 759
VAL A 760
HIS A 888
ILE A 913
 WOW  A   1 (-4.2A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.1A)
None
None
 1.43A 4okbA-3kbaA:
34.5		 4okbA-3kbaA:
54.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 721
GLY A 722
GLN A 725
MET A 756
MET A 759
VAL A 760
ARG A 766
HIS A 888
ILE A 913
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
None
None
 0.81A 4okbA-3kbaA:
34.5		 4okbA-3kbaA:
54.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 GLY A 429
MET A 487
VAL A 765
THR A 426
ILE A 404
 None
 1.35A 4okbA-3la4A:
undetectable		 4okbA-3la4A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2t PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00248
(Aldo_ket_red) 		5 LEU A 126
GLN A 128
LEU A 281
VAL A 205
ILE A  50
 None
 1.33A 4okbA-3n2tA:
undetectable		 4okbA-3n2tA:
21.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		7 LEU A  35
GLY A  36
GLN A  39
MET A  70
MET A  73
ARG A  80
ILE A 227
 1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
None
 0.70A 4okbA-3ry9A:
36.3		 4okbA-3ry9A:
54.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tj0 NUCLEOPROTEIN

(Influenza B
virus) 		PF00506
(Flu_NP) 		5 GLY A 247
LEU A 317
MET A 321
VAL A 322
ILE A 255
 None
 1.26A 4okbA-3tj0A:
undetectable		 4okbA-3tj0A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137

(Staphylococcus
aureus) 		PF13379
(NMT1_2) 		5 LEU A  78
GLY A  40
LEU A  50
VAL A 222
ILE A  37
 None
 1.33A 4okbA-3un6A:
undetectable		 4okbA-3un6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		5 LEU A  72
LEU A 174
MET A 135
VAL A 134
ILE A  51
 None
 1.28A 4okbA-3wjoA:
undetectable		 4okbA-3wjoA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwn ORFF

(Thermus
thermophilus) 		PF08271
(TF_Zn_Ribbon) 		5 LEU B  37
GLY B  36
LEU B  42
VAL B   2
MET B   1
 None
 1.41A 4okbA-3wwnB:
undetectable		 4okbA-3wwnB:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyz RIBONUCLEASE P
PROTEIN COMPONENT 3

(Thermococcus
kodakarensis) 		PF01876
(RNase_P_p30) 		5 GLY A  93
GLN A  92
LEU A 110
ARG A  19
THR A 162
 None
GOL  A 301 (-2.5A)
None
GOL  A 301 (-2.9A)
None
 1.40A 4okbA-3wyzA:
undetectable		 4okbA-3wyzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 GLY A 652
LEU A 812
MET A 780
VAL A 781
ILE A 670
 None
 1.30A 4okbA-3zyvA:
undetectable		 4okbA-3zyvA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		5 LEU A  80
GLY A  63
LEU A 167
VAL A  66
ILE A 157
 None
 1.34A 4okbA-4bjuA:
undetectable		 4okbA-4bjuA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btg MAJOR INNER PROTEIN
P1

(Pseudomonas
virus phi6) 		no annotation 5 LEU A 439
GLY A 440
VAL A 457
HIS A 630
ILE A 632
 None
 1.37A 4okbA-4btgA:
undetectable		 4okbA-4btgA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwe GLYPICAN-1

(Homo sapiens) 		PF01153
(Glypican) 		5 LEU A 227
GLY A 226
LEU A 467
MET A 297
VAL A 298
 None
 1.29A 4okbA-4bweA:
undetectable		 4okbA-4bweA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 LEU A 631
GLY A 630
LEU A 653
VAL A 469
THR A 647
 None
 1.12A 4okbA-4c51A:
undetectable		 4okbA-4c51A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4r PHOSPHATE
ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF01515
(PTA_PTB) 		5 GLY A  24
LEU A  56
ARG A 308
THR A  34
ILE A  64
 None
 1.32A 4okbA-4e4rA:
undetectable		 4okbA-4e4rA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee1 DNA PRIMASE

(Staphylococcus
aureus) 		PF08275
(Toprim_N)
PF13155
(Toprim_2) 		5 LEU A 245
VAL A 283
ARG A 156
HIS A 294
THR A 288
 None
 1.36A 4okbA-4ee1A:
undetectable		 4okbA-4ee1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eud SUCCINYL-COA:ACETATE
COENZYME A
TRANSFERASE

(Acetobacter
aceti) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 LEU A 266
GLY A 291
LEU A 304
MET A 309
ILE A 339
 None
 1.34A 4okbA-4eudA:
undetectable		 4okbA-4eudA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezb UNCHARACTERIZED
CONSERVED PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 LEU A 190
LEU A 290
VAL A 285
THR A 226
ILE A 261
 None
 1.25A 4okbA-4ezbA:
undetectable		 4okbA-4ezbA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		5 LEU A 214
GLY A 213
MET A 174
HIS A  76
ILE A  46
 None
None
None
GOL  A 402 (-4.4A)
GOL  A 402 (-4.3A)
 1.37A 4okbA-4f62A:
3.1		 4okbA-4f62A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF12741
(SusD-like) 		5 LEU A 146
GLN A  55
VAL A 208
THR A 130
ILE A 129
 None
 1.25A 4okbA-4f7aA:
undetectable		 4okbA-4f7aA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		5 GLY A 361
GLN A 362
LEU A 244
MET A 240
VAL A 239
 None
 1.40A 4okbA-4fixA:
undetectable		 4okbA-4fixA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP1

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 LEU A 126
LEU A  76
MET A 179
THR A  56
ILE A  42
 None
 1.28A 4okbA-4gh4A:
undetectable		 4okbA-4gh4A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0n DNMT2

(Spodoptera
frugiperda) 		PF00145
(DNA_methylase) 		5 LEU A 326
LEU A  24
HIS A   3
THR A  71
ILE A   5
 None
 1.21A 4okbA-4h0nA:
undetectable		 4okbA-4h0nA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6n AMINODEOXYCHORISMATE
LYASE

(Saccharomyces
cerevisiae) 		PF01063
(Aminotran_4) 		5 LEU A 326
GLY A 328
ARG A 255
THR A 318
ILE A 340
 PLP  A 500 (-4.1A)
PLP  A 500 (-3.4A)
PLP  A 500 (-3.0A)
None
None
 1.26A 4okbA-4k6nA:
undetectable		 4okbA-4k6nA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7t NANU SIALIC ACID
BINDING PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 LEU A  46
LEU A 138
MET A 134
MET A 109
ILE A 385
 None
 1.40A 4okbA-4l7tA:
undetectable		 4okbA-4l7tA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Proteus
mirabilis) 		PF02028
(BCCT) 		5 LEU A 403
LEU A 268
MET A 269
VAL A 273
ILE A 413
 None
 0.96A 4okbA-4m8jA:
undetectable		 4okbA-4m8jA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 LEU A 398
GLY A 397
LEU A 363
MET A 465
VAL A 463
 None
 1.00A 4okbA-4n78A:
undetectable		 4okbA-4n78A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 LEU A 398
GLY A 397
MET A 465
VAL A 463
HIS A 356
 None
 1.27A 4okbA-4n78A:
undetectable		 4okbA-4n78A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2

(Homo sapiens) 		PF00254
(FKBP_C) 		5 GLY A  99
LEU A 134
MET A  54
VAL A 131
ILE A 136
 None
 1.35A 4okbA-4nnrA:
undetectable		 4okbA-4nnrA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqy ISOPROPYLMALATE/CITR
AMALATE ISOMERASE
LARGE SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		5 LEU A  46
LEU A  81
MET A  82
VAL A  86
ILE A  37
 None
 1.16A 4okbA-4nqyA:
undetectable		 4okbA-4nqyA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 GLY A 242
LEU A 240
MET A 170
VAL A 167
HIS A 194
 None
 1.41A 4okbA-4ox2A:
undetectable		 4okbA-4ox2A:
17.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 566
GLY A 567
GLN A 570
MET A 601
ARG A 611
ILE A 757
 MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
None
 0.82A 4okbA-4p6wA:
32.4		 4okbA-4p6wA:
50.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 566
GLY A 567
GLN A 570
MET A 604
ARG A 611
ILE A 757
 MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-4.2A)
None
 0.97A 4okbA-4p6wA:
32.4		 4okbA-4p6wA:
50.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 772
GLN A 776
MET A 807
ARG A 817
ILE A 964
 CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
None
 0.81A 4okbA-4udbA:
33.1		 4okbA-4udbA:
52.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utg SUGAR KINASE

(Burkholderia
pseudomallei) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A  82
LEU A 104
MET A 126
VAL A 125
THR A  60
 None
 1.40A 4okbA-4utgA:
undetectable		 4okbA-4utgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		5 GLY A 948
LEU A 951
VAL A 624
MET A 623
ARG A 274
 None
 1.30A 4okbA-4xgtA:
undetectable		 4okbA-4xgtA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by7 3-OXOACYL-ACP
SYNTHASE III

(Verrucosispora
maris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 303
GLY A 304
VAL A 260
ARG A 240
ILE A 284
 None
 1.40A 4okbA-5by7A:
undetectable		 4okbA-5by7A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chs RNA-DIRECTED RNA
POLYMERASE L

(Indiana
vesiculovirus) 		PF00946
(Mononeg_RNA_pol) 		5 GLY A 359
LEU A  99
MET A  95
MET A  91
ILE A 239
 None
 0.96A 4okbA-5chsA:
undetectable		 4okbA-5chsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.14A 4okbA-5d6nA:
undetectable		 4okbA-5d6nA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.07A 4okbA-5ey8A:
undetectable		 4okbA-5ey8A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32

(Mycobacterium
marinum) 		PF00501
(AMP-binding) 		5 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.22A 4okbA-5ey9A:
undetectable		 4okbA-5ey9A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		5 LEU A 536
GLY A 501
VAL A 497
THR A 562
ILE A 591
 None
 1.40A 4okbA-5fg3A:
undetectable		 4okbA-5fg3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Homo sapiens) 		PF00009
(GTP_EFTU) 		5 GLY A 134
LEU A  13
MET A 113
VAL A  10
ILE A 100
 None
 1.41A 4okbA-5izkA:
undetectable		 4okbA-5izkA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00171
(Aldedh) 		5 LEU A 274
GLY A 192
MET A 265
THR A 195
ILE A 204
 None
 1.36A 4okbA-5jfmA:
undetectable		 4okbA-5jfmA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		5 LEU A 638
GLY A 637
LEU A 660
VAL A 477
THR A 654
 None
 1.02A 4okbA-5kqiA:
undetectable		 4okbA-5kqiA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 772
GLN A 776
MET A 807
ARG A 817
ILE A 964
 ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
None
 0.74A 4okbA-5mwpA:
36.7		 4okbA-5mwpA:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 GLY A 563
GLN A 566
MET A 597
MET A 600
ARG A 607
 486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
None
486  A 801 (-3.5A)
 0.80A 4okbA-5uc1A:
22.5		 4okbA-5uc1A:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  35
GLY A  36
GLN A  39
MET A  70
ARG A  80
ILE A 226
 1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
None
 0.79A 4okbA-5ufsA:
34.3		 4okbA-5ufsA:
54.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  35
GLY A  36
GLN A  39
MET A  73
ARG A  80
ILE A 226
 1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
None
 0.95A 4okbA-5ufsA:
34.3		 4okbA-5ufsA:
54.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03739
(YjgP_YjgQ) 		5 LEU G 285
LEU G 107
MET G 106
MET G 103
VAL G 102
 None
 1.41A 4okbA-5x5yG:
2.1		 4okbA-5x5yG:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7f PUTATIVE
O-METHYLTRANSFERASE
RV1220C

(Mycobacterium
tuberculosis) 		PF01596
(Methyltransf_3) 		5 LEU A 124
GLY A 151
LEU A 155
VAL A  62
ILE A 192
 None
 1.40A 4okbA-5x7fA:
undetectable		 4okbA-5x7fA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8g 2-SUCCINYLBENZOATE--
COA LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A  22
LEU A   9
VAL A  70
MET A  66
ILE A 208
 None
MG  A 503 ( 4.3A)
None
None
None
 1.25A 4okbA-5x8gA:
undetectable		 4okbA-5x8gA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
BETA-CATENIN-LIKE
PROTEIN HMP-2

(Caenorhabditis
elegans) 		PF01044
(Vinculin)
no annotation 		5 LEU A 126
GLY A 123
LEU B  67
VAL A  51
ILE A 118
 None
 1.35A 4okbA-5xa5A:
undetectable		 4okbA-5xa5A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu1 LYSINE
CYCLODEAMINASE

(Streptomyces
pristinaespiralis) 		no annotation 5 LEU A 117
LEU A  23
MET A  24
HIS A 155
THR A 152
 None
 1.17A 4okbA-5yu1A:
undetectable		 4okbA-5yu1A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 5 LEU A 698
GLY A 728
VAL A 644
MET A 645
ILE A 411
 None
 1.05A 4okbA-6a91A:
undetectable		 4okbA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3y DENN
DOMAIN-CONTAINING
PROTEIN 3

(Mus musculus) 		no annotation 5 LEU A 917
LEU A 885
MET A 889
VAL A 890
MET A 893
 None
 1.30A 4okbA-6b3yA:
undetectable		 4okbA-6b3yA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4o GLUTATHIONE
REDUCTASE

(Enterococcus
faecalis) 		no annotation 5 GLY A 317
GLN A 290
LEU A 135
VAL A 303
ILE A  16
 None
 1.26A 4okbA-6b4oA:
undetectable		 4okbA-6b4oA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 5 GLY A  53
LEU A 511
MET A 501
HIS A 486
ILE A  84
 None
None
None
SO4  A 608 (-4.8A)
None
 1.34A 4okbA-6byxA:
undetectable		 4okbA-6byxA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzg PROTEIN ZIP2
SPORULATION-SPECIFIC
PROTEIN 16

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B 654
GLY B 655
MET A 151
VAL A 149
THR B 689
 None
 1.35A 4okbA-6bzgB:
undetectable		 4okbA-6bzgB:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dju AROMATIC
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		4 LEU A 305
ASN A 306
MET A 339
LEU A 383
 None
 1.11A 4okbA-1djuA:
0.0		 4okbA-1djuA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7o GLUTAREDOXIN 2

(Escherichia
coli) 		PF04399
(Glutaredoxin2_C)
PF13417
(GST_N_3) 		4 LEU A  90
ASN A  94
LEU A 179
VAL A 185
 None
 1.11A 4okbA-1g7oA:
undetectable		 4okbA-1g7oA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		4 LEU A 606
ASN A 603
LEU A 577
VAL A 498
 None
CL  A2004 (-4.1A)
None
None
 1.19A 4okbA-1itkA:
undetectable		 4okbA-1itkA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 LEU A 112
ASN A 113
LEU A  85
VAL A  51
 None
 0.97A 4okbA-1l8kA:
undetectable		 4okbA-1l8kA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1noz DNA POLYMERASE

(Escherichia
virus T4) 		PF03104
(DNA_pol_B_exo1) 		4 ASN A 110
MET A 356
LEU A 273
VAL A 290
 None
 1.17A 4okbA-1nozA:
undetectable		 4okbA-1nozA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 LEU C 436
ASN C 437
LEU C 443
VAL A 156
 None
 0.97A 4okbA-1o7dC:
0.8		 4okbA-1o7dC:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcw FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF01070
(FMN_dh) 		4 LEU A 230
LEU A 265
MET A 226
VAL A 274
 None
 1.15A 4okbA-1qcwA:
0.0		 4okbA-1qcwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 LEU A  62
ASN A  63
LEU A 325
VAL A 284
 None
 1.10A 4okbA-1qdlA:
0.0		 4okbA-1qdlA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrd QUINONE-REDUCTASE

(Rattus rattus) 		PF02525
(Flavodoxin_2) 		4 ASN A  18
MET A 164
LEU A 188
VAL A 203
 FAD  A 274 (-3.8A)
None
None
None
 1.13A 4okbA-1qrdA:
undetectable		 4okbA-1qrdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyr HIGH LEVEL
KASUGAMYCIN
RESISTANCE PROTEIN

(Escherichia
coli) 		PF00398
(RrnaAD) 		4 LEU A  20
ASN A 113
LEU A 174
VAL A 145
 None
 1.17A 4okbA-1qyrA:
undetectable		 4okbA-1qyrA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrm LACTALDEHYDE
REDUCTASE

(Escherichia
coli) 		PF00465
(Fe-ADH) 		4 LEU A 261
ASN A 292
LEU A 284
VAL A 327
 None
 1.16A 4okbA-1rrmA:
undetectable		 4okbA-1rrmA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A

([Haemophilus]
ducreyi) 		PF03498
(CDtoxinA) 		4 LEU A 161
MET A  78
LEU A  80
VAL A 193
 None
 1.19A 4okbA-1sr4A:
undetectable		 4okbA-1sr4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE

(Thermus
thermophilus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 LEU A  59
ASN A  58
LEU A 102
VAL A  41
 None
 1.03A 4okbA-1uekA:
undetectable		 4okbA-1uekA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 321
ASN A 346
LEU A 382
VAL A 378
 None
 1.04A 4okbA-1ulqA:
undetectable		 4okbA-1ulqA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 LEU A 165
ASN A 160
LEU A 179
VAL A 219
 None
None
None
MG  A1102 (-4.7A)
 1.15A 4okbA-1vclA:
undetectable		 4okbA-1vclA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztc HYPOTHETICAL PROTEIN
TM0894

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		4 LEU A  66
MET A   1
LEU A 149
VAL A 189
 None
None
None
MPD  A 304 (-4.5A)
 1.16A 4okbA-1ztcA:
undetectable		 4okbA-1ztcA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 704
ASN A 705
MET A 787
LEU A 873
MET A 895
VAL A 903
 BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.4A)
None
None
 0.43A 4okbA-2ax9A:
41.3		 4okbA-2ax9A:
99.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azn PUTATIVE
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Methanocaldococcus
jannaschii) 		PF01872
(RibD_C) 		4 LEU A 159
ASN A 160
LEU A 168
VAL A 222
 NAP  A2001 (-4.8A)
None
None
None
 1.10A 4okbA-2aznA:
undetectable		 4okbA-2aznA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 203
ASN A 122
MET A 256
LEU A 170
VAL A 350
 None
 1.33A 4okbA-2b1pA:
undetectable		 4okbA-2b1pA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2c SPERMIDINE SYNTHASE

(Caenorhabditis
elegans) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 MET A 261
LEU A  98
MET A 137
VAL A 126
 None
 1.00A 4okbA-2b2cA:
undetectable		 4okbA-2b2cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 LEU A 138
ASN A 136
LEU A 146
VAL A 106
 None
 1.12A 4okbA-2csdA:
undetectable		 4okbA-2csdA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		4 ASN A 410
MET A 371
LEU A 403
VAL A 249
 None
 1.09A 4okbA-2dfsA:
undetectable		 4okbA-2dfsA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Staphylococcus
aureus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 378
MET A 284
LEU A 301
VAL A 363
 None
 1.20A 4okbA-2gqdA:
undetectable		 4okbA-2gqdA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3g BIOSYNTHETIC PROTEIN

(Bacillus
anthracis) 		PF03309
(Pan_kinase) 		4 LEU X  73
MET X  28
LEU X  14
VAL X  57
 None
 1.03A 4okbA-2h3gX:
undetectable		 4okbA-2h3gX:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Arabidopsis
thaliana) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 378
MET A 437
LEU A 431
VAL A 417
 None
 1.20A 4okbA-2ix4A:
undetectable		 4okbA-2ix4A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4x MITOGEN

(Streptococcus
dysgalactiae) 		PF02876
(Stap_Strp_tox_C) 		4 LEU A 205
ASN A 206
LEU A 181
VAL A   3
 None
None
None
GOL  A1213 ( 4.7A)
 1.08A 4okbA-2j4xA:
undetectable		 4okbA-2j4xA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		4 LEU A 272
ASN A 343
LEU A 412
VAL A 449
 None
 1.19A 4okbA-2jf7A:
undetectable		 4okbA-2jf7A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		4 LEU A 419
MET A 260
LEU A 354
VAL A 245
 None
 1.17A 4okbA-2odpA:
undetectable		 4okbA-2odpA:
20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		4 LEU A  32
ASN A  33
MET A 115
LEU A 201
 1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 3.7A)
1CA  A 247 ( 4.2A)
 0.90A 4okbA-2q3yA:
36.8		 4okbA-2q3yA:
59.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe8 UNCHARACTERIZED
PROTEIN

(Trichormus
variabilis) 		PF03022
(MRJP) 		4 LEU A 316
ASN A 317
MET A 213
LEU A 173
 UNL  A 344 ( 4.9A)
None
UNL  A 344 ( 4.2A)
None
 1.18A 4okbA-2qe8A:
undetectable		 4okbA-2qe8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 LEU A 201
ASN A 246
LEU A 209
VAL A 342
 None
 1.17A 4okbA-2uvfA:
undetectable		 4okbA-2uvfA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4y URIDYLATE KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 LEU A 162
LEU A 238
MET A 200
VAL A 192
 None
 1.04A 4okbA-2v4yA:
undetectable		 4okbA-2v4yA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 LEU A 488
ASN A 107
LEU A 102
VAL A  89
 None
 1.07A 4okbA-2v7gA:
undetectable		 4okbA-2v7gA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vo9 L-ALANYL-D-GLUTAMATE
PEPTIDASE

(Listeria phage
A500) 		PF13539
(Peptidase_M15_4) 		4 LEU A  16
MET A 114
LEU A  88
VAL A  98
 None
 0.79A 4okbA-2vo9A:
undetectable		 4okbA-2vo9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0s PYRUVATE PHOSPHATE
DIKINASE

(Trypanosoma
brucei) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 LEU A 332
ASN A 328
LEU A 360
VAL A 247
 None
 1.20A 4okbA-2x0sA:
undetectable		 4okbA-2x0sA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 LEU A 141
MET A 160
LEU A 121
VAL A  38
 None
 1.15A 4okbA-2xsjA:
undetectable		 4okbA-2xsjA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 LEU A 110
ASN A 111
LEU A  83
VAL A  49
 None
 1.09A 4okbA-3a5kA:
undetectable		 4okbA-3a5kA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU B  75
ASN B  99
LEU B  59
VAL B 107
 None
 0.90A 4okbA-3a79B:
undetectable		 4okbA-3a79B:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6x (3R)-HYDROXYMYRISTOY
L-[ACYL-CARRIER-PROT
EIN] DEHYDRATASE

(Campylobacter
jejuni) 		PF07977
(FabA) 		4 ASN A 116
LEU A  71
MET A 120
VAL A  87
 None
 1.07A 4okbA-3d6xA:
undetectable		 4okbA-3d6xA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 MET A 797
LEU A 956
MET A 924
VAL A 966
 None
 1.20A 4okbA-3egwA:
undetectable		 4okbA-3egwA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek5 URIDYLATE KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase) 		4 LEU A 159
LEU A 235
MET A 197
VAL A 189
 None
 1.07A 4okbA-3ek5A:
undetectable		 4okbA-3ek5A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Nocardioides
aromaticivorans) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		4 LEU A 330
ASN A 334
LEU A 284
VAL A 262
 None
 1.16A 4okbA-3gcfA:
undetectable		 4okbA-3gcfA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Sphingomonas
sp. KA1) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		4 LEU A 296
MET A 300
LEU A 135
VAL A 129
 None
 1.18A 4okbA-3gkqA:
undetectable		 4okbA-3gkqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn6 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Borreliella
burgdorferi) 		PF01182
(Glucosamine_iso) 		4 LEU A 133
MET A  48
MET A 194
VAL A 188
 None
 1.17A 4okbA-3hn6A:
undetectable		 4okbA-3hn6A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ir4 GLUTAREDOXIN 2

(Salmonella
enterica) 		PF04399
(Glutaredoxin2_C)
PF13417
(GST_N_3) 		4 LEU A  90
ASN A  94
LEU A 179
VAL A 185
 None
CL  A 217 ( 4.5A)
None
None
 1.18A 4okbA-3ir4A:
undetectable		 4okbA-3ir4A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9t V-TYPE PROTON ATPASE
SUBUNIT H

(Saccharomyces
cerevisiae) 		PF03224
(V-ATPase_H_N)
PF11698
(V-ATPase_H_C) 		4 LEU P 274
MET P 211
LEU P 263
VAL P 302
 None
 0.79A 4okbA-3j9tP:
undetectable		 4okbA-3j9tP:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyj PUTATIVE HISTIDINE
PROTEIN KINASE

(Rhodobacter
sphaeroides) 		PF01627
(Hpt) 		4 LEU A 127
MET A  26
LEU A 101
VAL A 115
 None
 1.12A 4okbA-3kyjA:
undetectable		 4okbA-3kyjA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdu N-FORMIMINO-L-GLUTAM
ATE IMINOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		4 LEU A 406
ASN A 407
MET A  52
LEU A 331
 None
 1.16A 4okbA-3mduA:
undetectable		 4okbA-3mduA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrn UNCHARACTERIZED
PROTEIN PF1083

(Pyrococcus
furiosus) 		PF01593
(Amino_oxidase) 		4 LEU A  69
LEU A  10
MET A 397
VAL A 377
 None
 1.16A 4okbA-3nrnA:
undetectable		 4okbA-3nrnA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv0 NTF2-RELATED EXPORT
PROTEIN
NUCLEAR RNA EXPORT
FACTOR 2

(Caenorhabditis
elegans) 		PF02136
(NTF2)
no annotation 		4 ASN B  56
MET B  91
LEU A 326
VAL A 212
 NA  A 457 ( 3.2A)
PEG  B1004 ( 4.2A)
None
None
 1.19A 4okbA-3nv0B:
undetectable		 4okbA-3nv0B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE

(Escherichia
coli) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		4 LEU A 614
ASN A 360
MET A 321
LEU A 263
 None
 1.18A 4okbA-3o98A:
undetectable		 4okbA-3o98A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		4 LEU A 774
MET A 842
LEU A 789
MET A 742
 None
 1.19A 4okbA-3qcwA:
undetectable		 4okbA-3qcwA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 491
ASN A 490
LEU A 474
VAL A 522
 None
 1.14A 4okbA-3rg1A:
undetectable		 4okbA-3rg1A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rlf MALTOSE TRANSPORT
SYSTEM PERMEASE
PROTEIN MALG

(Escherichia
coli) 		PF00528
(BPD_transp_1) 		4 LEU G 156
ASN G 157
LEU G 235
VAL G 247
 None
 1.01A 4okbA-3rlfG:
undetectable		 4okbA-3rlfG:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		4 LEU A  32
ASN A  33
MET A 115
LEU A 201
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 0.95A 4okbA-3ry9A:
36.3		 4okbA-3ry9A:
54.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		4 LEU A  77
MET A 108
LEU A  32
MET A  40
 1CA  A 249 ( 4.1A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.9A)
None
 1.19A 4okbA-3ry9A:
36.3		 4okbA-3ry9A:
54.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se5 CELL FILAMENTATION
PROTEIN FIC-RELATED
PROTEIN

(Neisseria
meningitidis) 		PF02661
(Fic) 		4 LEU A  82
LEU A  42
MET A  88
VAL A 124
 None
 1.07A 4okbA-3se5A:
undetectable		 4okbA-3se5A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqq METHIONYL-TRNA
FORMYLTRANSFERASE

(Coxiella
burnetii) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 LEU A 306
MET A 244
LEU A 282
VAL A 252
 None
 1.15A 4okbA-3tqqA:
undetectable		 4okbA-3tqqA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvl HOMOSERINE
O-ACETYLTRANSFERASE

(Streptomyces
lavendulae) 		PF00561
(Abhydrolase_1) 		4 LEU A  39
ASN A  40
LEU A 142
VAL A 373
 None
 1.19A 4okbA-3vvlA:
undetectable		 4okbA-3vvlA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu9 BETA-GALACTOSIDASE

(Streptococcus
pneumoniae) 		no annotation 4 LEU A1850
ASN A1851
MET A1977
VAL A1891
 None
 0.87A 4okbA-4cu9A:
undetectable		 4okbA-4cu9A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		4 MET A 560
LEU A 509
MET A 846
VAL A 801
 None
 1.09A 4okbA-4czwA:
undetectable		 4okbA-4czwA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecg PUTATIVE
IRON-REGULATED
PROTEIN A

(Parabacteroides
distasonis) 		PF09375
(Peptidase_M75) 		4 LEU A 117
MET A  73
LEU A 213
VAL A 226
 None
 1.15A 4okbA-4ecgA:
undetectable		 4okbA-4ecgA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 4 LEU A 585
ASN A 583
LEU A 603
VAL A 418
 None
 1.19A 4okbA-4ecoA:
undetectable		 4okbA-4ecoA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 747
ASN A 746
LEU A 434
VAL A 655
 None
None
None
SO4  A1020 ( 4.8A)
 0.96A 4okbA-4fysA:
undetectable		 4okbA-4fysA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gij PSEUDOURIDINE-5'-PHO
SPHATE GLYCOSIDASE

(Escherichia
coli) 		PF04227
(Indigoidine_A) 		4 LEU A 299
ASN A 296
MET A 219
VAL A 113
 None
 1.10A 4okbA-4gijA:
undetectable		 4okbA-4gijA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k37 ANAEROBIC
SULFATASE-MATURATING
ENZYME

(Clostridium
perfringens) 		PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12) 		4 LEU A 218
MET A 257
LEU A 243
VAL A 365
 None
 1.18A 4okbA-4k37A:
undetectable		 4okbA-4k37A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lla LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 2

(Homo sapiens) 		PF13895
(Ig_2) 		4 LEU A 196
MET A 165
LEU A 138
VAL A  16
 None
 0.89A 4okbA-4llaA:
undetectable		 4okbA-4llaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 539
ASN A 537
MET A 547
LEU A 532
 None
 1.13A 4okbA-4mn8A:
undetectable		 4okbA-4mn8A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 539
ASN A 537
MET A 547
LEU A 532
 None
 1.07A 4okbA-4mnaA:
undetectable		 4okbA-4mnaA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		4 LEU A  31
ASN A  59
LEU A  26
VAL A  79
 None
 1.00A 4okbA-4otkA:
undetectable		 4okbA-4otkA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oz5 BACILLUS SUBTILIS
HMOB

(Bacillus
subtilis) 		PF03992
(ABM) 		4 LEU A  26
ASN A  24
LEU A 116
VAL A  54
 None
 1.14A 4okbA-4oz5A:
undetectable		 4okbA-4oz5A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcs ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01120
(Alpha_L_fucos) 		4 LEU A 263
ASN A 260
LEU A 213
VAL A 223
 None
 1.10A 4okbA-4pcsA:
undetectable		 4okbA-4pcsA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf7 ARGININE KINASE

(Anthopleura
japonica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 ASN A 685
LEU A 602
MET A 700
VAL A 464
 None
 1.11A 4okbA-4rf7A:
undetectable		 4okbA-4rf7A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04101
(Glyco_tran_28_C)
PF06925
(MGDG_synth) 		4 ASN A 449
MET A 417
LEU A 351
VAL A 482
 None
 1.12A 4okbA-4wyiA:
undetectable		 4okbA-4wyiA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg3 OUTER CAPSID PROTEIN
VP4

(Rotavirus A) 		no annotation 4 LEU A 202
ASN A 201
MET A 122
VAL A 119
 None
 1.15A 4okbA-4yg3A:
undetectable		 4okbA-4yg3A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 179
ASN A 180
LEU A 335
VAL A   6
 None
 1.13A 4okbA-4zo6A:
undetectable		 4okbA-4zo6A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		5 LEU A 163
ASN A  82
MET A 216
LEU A 130
VAL A 311
 None
 1.38A 4okbA-5awmA:
undetectable		 4okbA-5awmA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c12 GENE 2 PROTEIN

(Shigella virus
Sf6) 		PF17288
(Terminase_3C) 		4 LEU A 410
MET A 450
LEU A 391
VAL A 379
 None
 1.03A 4okbA-5c12A:
undetectable		 4okbA-5c12A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC

(Neisseria
meningitidis) 		PF02661
(Fic) 		4 LEU A  82
LEU A  42
MET A  88
VAL A 124
 None
 1.11A 4okbA-5cglA:
undetectable		 4okbA-5cglA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjp RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP2

(Homo sapiens) 		PF00616
(RasGAP) 		4 LEU E1103
ASN E1102
LEU E 943
VAL E 951
 None
 1.02A 4okbA-5cjpE:
undetectable		 4okbA-5cjpE:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 LEU A  17
ASN A  47
MET A  41
VAL A 377
 None
 1.18A 4okbA-5dfaA:
undetectable		 4okbA-5dfaA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		4 ASN A2130
MET A2288
LEU A2308
VAL A2356
 None
 1.17A 4okbA-5fu7A:
undetectable		 4okbA-5fu7A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwz SYNAPTONEMAL COMPLEX
PROTEIN 2

(Mus musculus) 		no annotation 4 LEU A 180
MET A 196
MET A 134
VAL A  97
 None
 1.13A 4okbA-5iwzA:
undetectable		 4okbA-5iwzA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm6 AMINOPEPTIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF02127
(Peptidase_M18) 		4 LEU A 332
MET A 470
LEU A 387
VAL A 477
 None
 1.21A 4okbA-5jm6A:
undetectable		 4okbA-5jm6A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k50 L-THREONINE
3-DEHYDROGENASE

(Trypanosoma
brucei) 		no annotation 4 LEU A1057
ASN A1098
LEU A1091
VAL A1143
 NAD  A1401 ( 4.9A)
None
None
None
 1.08A 4okbA-5k50A:
undetectable		 4okbA-5k50A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 LEU B 334
MET B 817
LEU B 786
VAL B 879
 None
 0.91A 4okbA-5kyuB:
undetectable		 4okbA-5kyuB:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5x DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA135

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF06883
(RNA_pol_Rpa2_4) 		4 LEU B  61
ASN B  62
LEU B 137
VAL B 155
 None
 1.02A 4okbA-5m5xB:
undetectable		 4okbA-5m5xB:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 4 LEU A 769
ASN A 770
MET A 852
LEU A 938
 ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 (-3.7A)
ECV  A1101 ( 4.3A)
 0.94A 4okbA-5mwpA:
36.7		 4okbA-5mwpA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsq AMINOPEPTIDASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00883
(Peptidase_M17) 		4 LEU A 339
LEU A 212
MET A 399
VAL A 500
 None
 1.12A 4okbA-5nsqA:
undetectable		 4okbA-5nsqA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1

(Homo sapiens) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF08412
(Ion_trans_N) 		4 LEU A 301
ASN A 300
MET A 356
VAL A 154
 None
 1.16A 4okbA-5u6oA:
undetectable		 4okbA-5u6oA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubj ALPHA-L-ARABINOFURAN
OSIDASE AXHA-2

(Aspergillus
nidulans) 		PF03664
(Glyco_hydro_62) 		4 LEU A  61
MET A  95
LEU A 115
VAL A 161
 None
 1.16A 4okbA-5ubjA:
undetectable		 4okbA-5ubjA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		4 LEU A  55
ASN A  57
LEU A 277
VAL A 120
 None
 1.03A 4okbA-5um2A:
undetectable		 4okbA-5um2A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5) 		PF01801
(Cytomega_gL)
PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 LEU A 106
ASN A 107
LEU B  72
VAL B  75
 None
 1.02A 4okbA-5vocA:
undetectable		 4okbA-5vocA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Homo sapiens) 		no annotation 4 LEU i 251
LEU i 179
MET i 187
VAL i 115
 None
 1.17A 4okbA-5xtci:
undetectable		 4okbA-5xtci:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv5 CONSERVED PROTEIN

(Methanosarcina
mazei) 		no annotation 4 LEU A 161
ASN A 162
LEU A 170
VAL A 223
 None
 1.11A 4okbA-5xv5A:
undetectable		 4okbA-5xv5A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE

(Sorghum bicolor) 		no annotation 4 ASN A 678
MET A 410
LEU A 495
VAL A 259
 None
 1.09A 4okbA-6at7A:
undetectable		 4okbA-6at7A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9h PROTEIN HOOK HOMOLOG
3

(Homo sapiens) 		no annotation 4 LEU A 123
MET A 142
MET A  41
VAL A  25
 None
 1.14A 4okbA-6b9hA:
undetectable		 4okbA-6b9hA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhc PSEUDOPODIUM-ENRICHE
D ATYPICAL KINASE 1

(Homo sapiens) 		no annotation 4 LEU A1551
ASN A1386
MET A1602
LEU A1497
 None
 1.12A 4okbA-6bhcA:
undetectable		 4okbA-6bhcA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 4 LEU A 172
MET A 359
LEU A 386
MET A 458
 None
 1.11A 4okbA-6cgmA:
undetectable		 4okbA-6cgmA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co1 TUDOR-INTERACTING
REPAIR REGULATOR
PROTEIN

(Homo sapiens) 		no annotation 4 LEU A 147
MET A  52
LEU A 173
VAL A   6
 None
 1.12A 4okbA-6co1A:
undetectable		 4okbA-6co1A:
16.18