SIMILAR PATTERNS OF AMINO ACIDS FOR 4OK1_A_198A1001_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h1y | D-RIBULOSE-5-PHOSPHATE 3-EPIMERASE (Oryza sativa) |
PF00834(Ribul_P_3_epim) | 4 | ASN A 100MET A 113LEU A 70ILE A 94 | None | 1.05A | 4ok1A-1h1yA:undetectable | 4ok1A-1h1yA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ipf | TROPINONEREDUCTASE-II (Daturastramonium) |
PF13561(adh_short_C2) | 4 | LEU A 91ASN A 93LEU A 76ILE A 117 | NoneNoneNoneNDP A 261 ( 4.1A) | 1.00A | 4ok1A-1ipfA:undetectable | 4ok1A-1ipfA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jhd | SULFATEADENYLYLTRANSFERASE (Sulfur-oxidizingendosymbiont ofRiftiapachyptila) |
PF01747(ATP-sulfurylase)PF14306(PUA_2) | 4 | LEU A 55MET A 131LEU A 84ILE A 117 | None | 0.90A | 4ok1A-1jhdA:undetectable | 4ok1A-1jhdA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k1b | B-CELL LYMPHOMA3-ENCODED PROTEIN (Homo sapiens) |
PF00023(Ank)PF12796(Ank_2) | 4 | LEU A 286LEU A 238HIS A 239ILE A 273 | None | 0.89A | 4ok1A-1k1bA:undetectable | 4ok1A-1k1bA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m72 | CASPASE-1 (Spodopterafrugiperda) |
PF00656(Peptidase_C14) | 4 | LEU A 240MET A 55LEU A 291ILE A 212 | None | 0.98A | 4ok1A-1m72A:undetectable | 4ok1A-1m72A:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m9q | ENDOTHELIALNITRIC-OXIDESYNTHASE (Homo sapiens) |
PF02898(NO_synthase) | 4 | LEU A 292ASN A 245LEU A 304ILE A 215 | None | 1.07A | 4ok1A-1m9qA:undetectable | 4ok1A-1m9qA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ukv | GTP-BINDING PROTEINYPT1 (Saccharomycescerevisiae) |
PF00071(Ras) | 4 | ASN Y 16MET Y 145LEU Y 103ILE Y 73 | None | 0.92A | 4ok1A-1ukvY:undetectable | 4ok1A-1ukvY:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uzg | MAJOR ENVELOPEPROTEIN E (Dengue virus) |
PF00869(Flavi_glycoprot)PF02832(Flavi_glycop_C) | 4 | LEU A 25MET A 287LEU A 41HIS A 144 | None | 0.97A | 4ok1A-1uzgA:undetectable | 4ok1A-1uzgA:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vrn | PHOTOSYNTHETICREACTION CENTERCYTOCHROME C SUBUNIT (Blastochlorisviridis) |
PF02276(CytoC_RC) | 4 | LEU C 282ASN C 278HIS C 124ILE C 271 | HEM C 402 ( 4.5A)NoneHEM C 404 (-3.2A)HEM C 403 (-4.5A) | 1.05A | 4ok1A-1vrnC:undetectable | 4ok1A-1vrnC:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wst | MULTIPLE SUBSTRATEAMINOTRANSFERASE (Thermococcusprofundus) |
PF00155(Aminotran_1_2) | 4 | LEU A 326MET A 412MET A 358LEU A 349 | None | 0.99A | 4ok1A-1wstA:undetectable | 4ok1A-1wstA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x1q | TRYPTOPHAN SYNTHASEBETA CHAIN (Thermusthermophilus) |
PF00291(PALP) | 4 | LEU A 70ASN A 111LEU A 18ILE A 260 | NoneNoneNone CL A1001 (-4.0A) | 1.06A | 4ok1A-1x1qA:undetectable | 4ok1A-1x1qA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xhn | CELLULAR REPRESSOROF E1A-STIMULATEDGENES (Homo sapiens) |
PF13883(Pyrid_oxidase_2) | 4 | MET A 91LEU A 55HIS A 139ILE A 137 | None | 0.97A | 4ok1A-1xhnA:undetectable | 4ok1A-1xhnA:19.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ax9 | ANDROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 8 | LEU A 701ASN A 705MET A 745MET A 749MET A 787LEU A 873HIS A 874ILE A 898 | NoneBHM A 1 (-3.6A)BHM A 1 (-3.9A)BHM A 1 (-4.3A)BHM A 1 (-3.6A)BHM A 1 (-4.4A)NoneNone | 0.37A | 4ok1A-2ax9A:41.1 | 4ok1A-2ax9A:99.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bku | IMPORTIN BETA-1SUBUNIT (Saccharomycescerevisiae) |
PF03810(IBN_N)PF13513(HEAT_EZ) | 4 | MET B 162MET B 139LEU B 104ILE B 59 | None | 0.97A | 4ok1A-2bkuB:undetectable | 4ok1A-2bkuB:14.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dep | THERMOSTABLECELLOXYLANASE ([Clostridium]stercorarium) |
PF00331(Glyco_hydro_10) | 4 | LEU A 287ASN A 289LEU A 242ILE A 275 | None | 0.88A | 4ok1A-2depA:undetectable | 4ok1A-2depA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ess | ACYL-ACPTHIOESTERASE (Bacteroidesthetaiotaomicron) |
PF01643(Acyl-ACP_TE) | 4 | LEU A 52LEU A 129HIS A 130ILE A 138 | None | 1.03A | 4ok1A-2essA:undetectable | 4ok1A-2essA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eyq | TRANSCRIPTION-REPAIRCOUPLING FACTOR (Escherichiacoli) |
PF00270(DEAD)PF00271(Helicase_C)PF02559(CarD_CdnL_TRCF)PF03461(TRCF) | 4 | LEU A 754MET A 616LEU A 725ILE A 680 | None | 0.98A | 4ok1A-2eyqA:undetectable | 4ok1A-2eyqA:12.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gzs | IROE PROTEIN (Escherichiacoli) |
PF00756(Esterase) | 4 | MET A 242LEU A 239HIS A 238ILE A 302 | None | 1.06A | 4ok1A-2gzsA:undetectable | 4ok1A-2gzsA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hng | HYPOTHETICAL PROTEIN (Streptococcuspneumoniae) |
PF06619(DUF1149) | 4 | LEU A 7ASN A 78LEU A 91ILE A 58 | None | 1.02A | 4ok1A-2hngA:undetectable | 4ok1A-2hngA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j5b | TYROSYL-TRNASYNTHETASE (Acanthamoebapolyphagamimivirus) |
PF00579(tRNA-synt_1b) | 4 | LEU A 182ASN A 190MET A 127ILE A 204 | LEU A 182 (-0.6A)ASN A 190 ( 0.6A)MET A 127 ( 0.0A)ILE A 204 ( 0.7A) | 0.87A | 4ok1A-2j5bA:undetectable | 4ok1A-2j5bA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jx3 | PROTEIN DEK (Homo sapiens) |
PF02037(SAP) | 4 | LEU A 106LEU A 32HIS A 33ILE A 3 | None | 1.03A | 4ok1A-2jx3A:undetectable | 4ok1A-2jx3A:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nn3 | CASPASE-1 (Spodopterafrugiperda) |
PF00656(Peptidase_C14) | 4 | LEU C 240MET C 55LEU C 291ILE C 212 | None | 0.94A | 4ok1A-2nn3C:undetectable | 4ok1A-2nn3C:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oda | HYPOTHETICAL PROTEINPSPTO_2114 (Pseudomonassyringae groupgenomosp. 3) |
no annotation | 4 | LEU A 117MET A 77LEU A 17ILE A 173 | None | 1.00A | 4ok1A-2odaA:undetectable | 4ok1A-2odaA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2po4 | VIRION RNAPOLYMERASE (Escherichiavirus N4) |
no annotation | 4 | ASN A 617MET A 569LEU A 611ILE A 654 | None | 1.01A | 4ok1A-2po4A:undetectable | 4ok1A-2po4A:13.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2q3y | ANCESTRAL CORTICIODRECEPTOR (unidentified) |
PF00104(Hormone_recep) | 5 | ASN A 33MET A 73MET A 115LEU A 201ILE A 226 | 1CA A 247 (-2.9A)1CA A 247 (-3.6A)1CA A 247 ( 3.7A)1CA A 247 ( 4.2A)None | 0.87A | 4ok1A-2q3yA:37.1 | 4ok1A-2q3yA:59.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2q3y | ANCESTRAL CORTICIODRECEPTOR (unidentified) |
PF00104(Hormone_recep) | 5 | LEU A 29ASN A 33MET A 73MET A 115LEU A 201 | 1CA A 247 ( 3.6A)1CA A 247 (-2.9A)1CA A 247 (-3.6A)1CA A 247 ( 3.7A)1CA A 247 ( 4.2A) | 0.86A | 4ok1A-2q3yA:37.1 | 4ok1A-2q3yA:59.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3au9 | 1-DEOXY-D-XYLULOSE5-PHOSPHATEREDUCTOISOMERASE (Plasmodiumfalciparum) |
PF02670(DXP_reductoisom)PF08436(DXP_redisom_C)PF13288(DXPR_C) | 4 | LEU A 252MET A 464LEU A 187ILE A 177 | None | 1.05A | 4ok1A-3au9A:undetectable | 4ok1A-3au9A:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b2d | CD180 ANTIGEN (Homo sapiens) |
PF00560(LRR_1)PF13855(LRR_8) | 4 | LEU A 84ASN A 111HIS A 93ILE A 114 | None | 1.02A | 4ok1A-3b2dA:undetectable | 4ok1A-3b2dA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b95 | EUCHROMATICHISTONE-LYSINEN-METHYLTRANSFERASE1 (Homo sapiens) |
PF12796(Ank_2)PF13637(Ank_4) | 4 | LEU A 860LEU A 812HIS A 813ILE A 847 | None | 0.98A | 4ok1A-3b95A:undetectable | 4ok1A-3b95A:24.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d36 | SPORULATION KINASE B (Geobacillusstearothermophilus) |
PF00512(HisKA)PF02518(HATPase_c) | 4 | ASN A 320MET A 357LEU A 365ILE A 389 | NoneADP A 500 (-3.6A)ADP A 500 (-4.3A)None | 1.03A | 4ok1A-3d36A:undetectable | 4ok1A-3d36A:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dxo | UNCHARACTERIZEDSNOAL-LIKE PROTEIN (Agrobacteriumfabrum) |
PF12680(SnoaL_2) | 4 | LEU A 12ASN A 16MET A 53MET A 42 | NoneNoneNonePGE A 121 ( 4.3A) | 1.03A | 4ok1A-3dxoA:undetectable | 4ok1A-3dxoA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dzu | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 4 | MET D 463LEU D 453HIS D 449ILE D 326 | NoneNoneNonePLB D 701 ( 4.5A) | 0.97A | 4ok1A-3dzuD:18.1 | 4ok1A-3dzuD:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ew7 | LMO0794 PROTEIN (Listeriamonocytogenes) |
PF13460(NAD_binding_10) | 4 | LEU A 204ASN A 205LEU A 99ILE A 87 | None | 0.96A | 4ok1A-3ew7A:undetectable | 4ok1A-3ew7A:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g5i | PYRIMIDINE-SPECIFICRIBONUCLEOSIDEHYDROLASE RIHA (Escherichiacoli) |
PF01156(IU_nuc_hydro) | 4 | LEU A 6LEU A 140HIS A 141ILE A 176 | None | 1.06A | 4ok1A-3g5iA:undetectable | 4ok1A-3g5iA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gmg | UNCHARACTERIZEDPROTEINRV1825/MT1873 (Mycobacteriumtuberculosis) |
PF05949(DUF881) | 4 | ASN A 202MET A 184MET A 249LEU A 191 | None | 1.02A | 4ok1A-3gmgA:undetectable | 4ok1A-3gmgA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ihy | PHOSPHATIDYLINOSITOL3-KINASE CATALYTICSUBUNIT TYPE 3 (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka) | 4 | LEU A 665MET A 777MET A 859ILE A 650 | None | 0.99A | 4ok1A-3ihyA:undetectable | 4ok1A-3ihyA:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jbl | NLR FAMILY CARDDOMAIN-CONTAININGPROTEIN 4 (Mus musculus) |
no annotation | 4 | LEU K 847ASN K 843MET K 808LEU K 787 | None | 0.97A | 4ok1A-3jblK:undetectable | 4ok1A-3jblK:15.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kba | PROGESTERONERECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | ASN A 719MET A 759MET A 801LEU A 887HIS A 888 | WOW A 1 (-3.3A)WOW A 1 (-3.7A)WOW A 1 (-4.2A)WOW A 1 (-4.0A)None | 1.09A | 4ok1A-3kbaA:34.8 | 4ok1A-3kbaA:54.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kba | PROGESTERONERECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 715ASN A 719MET A 759MET A 801HIS A 888 | WOW A 1 (-3.9A)WOW A 1 (-3.3A)WOW A 1 (-3.7A)WOW A 1 (-4.2A)None | 0.95A | 4ok1A-3kbaA:34.8 | 4ok1A-3kbaA:54.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l3s | ENOYL-COAHYDRATASE/ISOMERASEFAMILY PROTEIN (Ruegeriapomeroyi) |
PF00378(ECH_1) | 4 | LEU A 10MET A 98LEU A 123ILE A 63 | None | 1.07A | 4ok1A-3l3sA:undetectable | 4ok1A-3l3sA:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o6x | GLUTAMINE SYNTHETASE (Bacteroidesfragilis) |
PF00120(Gln-synt_C)PF12437(GSIII_N) | 4 | LEU A 303ASN A 302MET A 41ILE A 168 | None | 0.92A | 4ok1A-3o6xA:undetectable | 4ok1A-3o6xA:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3olq | UNIVERSAL STRESSPROTEIN E (Proteusmirabilis) |
PF00582(Usp) | 4 | LEU A 298LEU A 7HIS A 109ILE A 100 | None | 1.07A | 4ok1A-3olqA:undetectable | 4ok1A-3olqA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p9u | TETX2 PROTEIN (Bacteroidesthetaiotaomicron) |
PF01494(FAD_binding_3) | 4 | ASN A 168LEU A 315HIS A 314ILE A 309 | FAD A 401 (-4.7A)NoneNoneNone | 0.96A | 4ok1A-3p9uA:undetectable | 4ok1A-3p9uA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q5e | ATLASTIN-1 (Homo sapiens) |
PF02263(GBP) | 4 | ASN A 177MET A 87LEU A 297ILE A 213 | None | 1.03A | 4ok1A-3q5eA:undetectable | 4ok1A-3q5eA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rg1 | CD180 MOLECULE (Bos taurus) |
PF00560(LRR_1)PF13855(LRR_8) | 4 | LEU A 84ASN A 111HIS A 93ILE A 114 | None | 0.97A | 4ok1A-3rg1A:undetectable | 4ok1A-3rg1A:16.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ry9 | ANCESTRALGLUCOCORTICOIDRECEPTOR 1 (syntheticconstruct) |
PF00104(Hormone_recep) | 4 | ASN A 33MET A 73LEU A 201ILE A 226 | 1CA A 249 (-3.0A)1CA A 249 (-3.9A)1CA A 249 ( 4.2A)None | 0.84A | 4ok1A-3ry9A:36.1 | 4ok1A-3ry9A:54.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sip | CASPASE (Drosophilamelanogaster) |
PF00656(Peptidase_C14) | 4 | LEU B 202MET A 15LEU B 253ILE B 174 | None | 0.96A | 4ok1A-3sipB:undetectable | 4ok1A-3sipB:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sir | CASPASE (Drosophilamelanogaster) |
PF00656(Peptidase_C14) | 4 | LEU A 202MET A 15LEU A 253ILE A 174 | None | 0.96A | 4ok1A-3sirA:undetectable | 4ok1A-3sirA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t6q | CD180 ANTIGEN (Mus musculus) |
PF13855(LRR_8) | 4 | LEU A 84ASN A 111HIS A 93ILE A 114 | None | 0.86A | 4ok1A-3t6qA:undetectable | 4ok1A-3t6qA:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uc9 | INCREASEDRECOMBINATIONCENTERS PROTEIN 6 (Saccharomycescerevisiae) |
no annotation | 4 | LEU A 166LEU A 21HIS A 18ILE A 92 | None | 1.02A | 4ok1A-3uc9A:undetectable | 4ok1A-3uc9A:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bev | COPPER EFFLUX ATPASE (Legionellapneumophila) |
PF00122(E1-E2_ATPase)PF00702(Hydrolase) | 4 | MET A 537MET A 539LEU A 438ILE A 281 | None | 0.84A | 4ok1A-4bevA:undetectable | 4ok1A-4bevA:15.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cuk | D-LACTATEDEHYDROGENASE (Salmonellaenterica) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 4 | LEU A 255LEU A 203HIS A 204ILE A 110 | None | 0.93A | 4ok1A-4cukA:undetectable | 4ok1A-4cukA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dxy | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 4 | LEU A 381LEU A 276HIS A 273ILE A 268 | NoneNonePEG A 506 (-3.7A)None | 1.05A | 4ok1A-4dxyA:2.4 | 4ok1A-4dxyA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4exj | UNCHARACTERIZEDPROTEIN (Lodderomyceselongisporus) |
PF00043(GST_C)PF13417(GST_N_3) | 4 | ASN A 205MET A 30LEU A 16ILE A 201 | None | 0.96A | 4ok1A-4exjA:undetectable | 4ok1A-4exjA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hu3 | OXYGEN SENSORPROTEIN DOSP (Escherichiacoli) |
PF00563(EAL) | 4 | LEU A 636MET A 690MET A 654LEU A 664 | None | 0.94A | 4ok1A-4hu3A:undetectable | 4ok1A-4hu3A:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hxq | ARGINASE-1 (Homo sapiens) |
PF00491(Arginase) | 4 | LEU A 216LEU A 229HIS A 228ILE A 169 | None | 0.81A | 4ok1A-4hxqA:undetectable | 4ok1A-4hxqA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l6u | PUTATIVEUNCHARACTERIZEDPROTEIN (Archaeoglobusfulgidus) |
PF03787(RAMPs) | 4 | LEU A 167MET A 37LEU A 10ILE A 283 | None | 0.91A | 4ok1A-4l6uA:undetectable | 4ok1A-4l6uA:24.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n8y | PUTATIVE TRAP-TYPEC4-DICARBOXYLATETRANSPORT SYSTEM,BINDING PERIPLASMICPROTEIN (DCTPSUBUNIT) (Bradyrhizobiumsp. BTAi1) |
PF03480(DctP) | 4 | LEU A 76MET A 44LEU A 235ILE A 125 | None | 1.01A | 4ok1A-4n8yA:undetectable | 4ok1A-4n8yA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ng4 | PHOSPHOGLYCERATEKINASE (Coxiellaburnetii) |
PF00162(PGK) | 4 | LEU A 94MET A 29LEU A 63HIS A 62 | None | 0.97A | 4ok1A-4ng4A:undetectable | 4ok1A-4ng4A:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1o | RIBONUCLEASE L (Sus scrofa) |
PF00069(Pkinase)PF06479(Ribonuc_2-5A)PF12796(Ank_2)PF13857(Ank_5) | 4 | LEU A 108LEU A 61HIS A 62ILE A 95 | None | 1.03A | 4ok1A-4o1oA:undetectable | 4ok1A-4o1oA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4om7 | TOLL-LIKE RECEPTOR 6 (Homo sapiens) |
PF01582(TIR) | 4 | ASN A 690LEU A 673HIS A 674ILE A 684 | None | 1.06A | 4ok1A-4om7A:undetectable | 4ok1A-4om7A:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ou4 | ALPHA/BETA HYDROLASEFOLD-3 DOMAINPROTEIN (Pseudomonas sp.ECU1011) |
PF07859(Abhydrolase_3) | 4 | LEU A 290ASN A 158MET A 212LEU A 91 | None | 1.01A | 4ok1A-4ou4A:undetectable | 4ok1A-4ou4A:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pue | ENDO-1,4-BETA-XYLANASE (Geobacillusstearothermophilus) |
PF00331(Glyco_hydro_10) | 4 | LEU A 259ASN A 261LEU A 214ILE A 247 | None | 0.87A | 4ok1A-4pueA:undetectable | 4ok1A-4pueA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qxe | LEUCINE-RICHREPEAT-CONTAININGG-PROTEIN COUPLEDRECEPTOR 4, LINKER,VARIABLE LYMPHOCYTERECEPTOR B (Eptatretusburgeri;Homo sapiens) |
PF01462(LRRNT)PF11921(DUF3439)PF13516(LRR_6)PF13855(LRR_8) | 4 | LEU A 247ASN A 271LEU A 232ILE A 263 | None | 1.02A | 4ok1A-4qxeA:undetectable | 4ok1A-4qxeA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rc6 | ALDEHYDEDECARBONYLASE (Synechococcuselongatus) |
PF11266(Ald_deCOase) | 4 | LEU B 108MET B 180LEU B 90HIS B 91 | None | 1.05A | 4ok1A-4rc6B:undetectable | 4ok1A-4rc6B:24.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4udb | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 4 | LEU A 766ASN A 770LEU A 938ILE A 963 | CV7 A1987 (-3.6A)CV7 A1987 (-3.1A)CV7 A1987 ( 3.9A)None | 0.64A | 4ok1A-4udbA:33.2 | 4ok1A-4udbA:52.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4udb | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 4 | LEU A 766MET A 852LEU A 938ILE A 963 | CV7 A1987 (-3.6A)CV7 A1987 ( 3.7A)CV7 A1987 ( 3.9A)None | 0.89A | 4ok1A-4udbA:33.2 | 4ok1A-4udbA:52.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yu9 | GLUTAMINYL-PEPTIDECYCLOTRANSFERASE (Homo sapiens) |
PF04389(Peptidase_M28) | 4 | LEU A 271MET A 166LEU A 247ILE A 303 | None | 1.03A | 4ok1A-4yu9A:undetectable | 4ok1A-4yu9A:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zrs | ESTERASE (unculturedbacterium) |
PF07859(Abhydrolase_3) | 4 | MET A 255MET A 223MET A 280LEU A 258 | None | 0.99A | 4ok1A-4zrsA:undetectable | 4ok1A-4zrsA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ck7 | ADP-DEPENDENTGLUCOKINASE (Mus musculus) |
PF04587(ADP_PFK_GK) | 4 | LEU A 243MET A 301LEU A 296HIS A 295 | None | 0.87A | 4ok1A-5ck7A:undetectable | 4ok1A-5ck7A:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e78 | BIFUNCTIONALP-450/NADPH-P450REDUCTASE (Bacillusmegaterium) |
PF00067(p450) | 4 | LEU A 133MET A 145LEU A 126ILE A 453 | None | 1.02A | 4ok1A-5e78A:undetectable | 4ok1A-5e78A:17.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f1p | PTMO8 (Streptomycesplatensis) |
PF13561(adh_short_C2) | 4 | LEU A 171ASN A 145LEU A 132ILE A 87 | None | 1.03A | 4ok1A-5f1pA:undetectable | 4ok1A-5f1pA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f9s | SERINE--PYRUVATEAMINOTRANSFERASE (Homo sapiens) |
PF00266(Aminotran_5) | 4 | ASN A 72MET A 230LEU A 179ILE A 220 | None | 0.96A | 4ok1A-5f9sA:undetectable | 4ok1A-5f9sA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fm2 | PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET (Homo sapiens) |
PF07714(Pkinase_Tyr) | 4 | LEU A 816MET A 984MET A 980ILE A 890 | None | 0.82A | 4ok1A-5fm2A:undetectable | 4ok1A-5fm2A:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ftf | TPR DOMAIN PROTEIN (Bacteroides sp.3_1_23) |
PF05970(PIF1) | 4 | LEU A 122LEU A 67HIS A 68ILE A 78 | None | 0.93A | 4ok1A-5ftfA:undetectable | 4ok1A-5ftfA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gjv | VOLTAGE-DEPENDENTL-TYPE CALCIUMCHANNEL SUBUNITALPHA-1S (Oryctolaguscuniculus) |
PF00520(Ion_trans)PF08763(Ca_chan_IQ)PF16905(GPHH) | 4 | LEU A 472ASN A 468LEU A 512ILE A 524 | None | 1.02A | 4ok1A-5gjvA:1.5 | 4ok1A-5gjvA:8.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hly | INHIBIN BETA A CHAIN (Homo sapiens) |
PF00019(TGF_beta)PF00688(TGFb_propeptide) | 4 | MET A 399MET A 401LEU A 66HIS A 67 | None | 0.97A | 4ok1A-5hlyA:undetectable | 4ok1A-5hlyA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jm0 | ALPHA-MANNOSIDASE,ALPHA-MANNOSIDASE,ALPHA-MANNOSIDASE (Saccharomycescerevisiae) |
PF01074(Glyco_hydro_38)PF07748(Glyco_hydro_38C)PF09261(Alpha-mann_mid) | 4 | LEU A 497ASN A 296HIS A 626ILE A 299 | None | 1.00A | 4ok1A-5jm0A:undetectable | 4ok1A-5jm0A:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m22 | HYDROQUINONEDIOXYGENASE LARGESUBUNITHYDROQUINONEDIOXYGENASE SMALLSUBUNIT (Sphingomonassp. TTNP3) |
no annotation | 4 | LEU A 148MET B 174LEU B 221ILE A 121 | None | 0.89A | 4ok1A-5m22A:undetectable | 4ok1A-5m22A:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m5p | PRE-MRNA-SPLICINGHELICASE BRR2 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C)PF02889(Sec63) | 4 | LEU A1511LEU A1384HIS A1387ILE A1506 | None | 0.88A | 4ok1A-5m5pA:undetectable | 4ok1A-5m5pA:8.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mrw | POTASSIUM-TRANSPORTING ATPASEPOTASSIUM-BINDINGSUBUNIT (Escherichiacoli) |
PF03814(KdpA) | 4 | LEU A 380MET A 17LEU A 284ILE A 532 | None | 1.01A | 4ok1A-5mrwA:undetectable | 4ok1A-5mrwA:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mwp | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
no annotation | 4 | ASN A 770MET A 852LEU A 938ILE A 963 | ECV A1101 (-3.1A)ECV A1101 (-3.7A)ECV A1101 ( 4.3A)None | 0.77A | 4ok1A-5mwpA:36.3 | 4ok1A-5mwpA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mwp | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
no annotation | 4 | LEU A 766ASN A 770LEU A 938ILE A 963 | ECV A1101 ( 3.9A)ECV A1101 (-3.1A)ECV A1101 ( 4.3A)None | 0.51A | 4ok1A-5mwpA:36.3 | 4ok1A-5mwpA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5npr | UDP-N-ACETYLGLUCOSAMINE--PEPTIDEN-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDASUBUNIT (Homo sapiens) |
no annotation | 4 | LEU A 583ASN A 630MET A 664LEU A 626 | None | 1.04A | 4ok1A-5nprA:undetectable | 4ok1A-5nprA:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5sv9 | BOR1P BORONTRANSPORTER (Saccharomycesmikatae) |
PF00955(HCO3_cotransp) | 4 | LEU A 415MET A 425LEU A 361HIS A 362 | None | 0.96A | 4ok1A-5sv9A:undetectable | 4ok1A-5sv9A:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5swu | PENTAFUNCTIONAL AROMPOLYPEPTIDE (Aspergillusfumigatus) |
PF01487(DHquinase_I) | 4 | ASN A1241MET A1285LEU A1252ILE A1238 | None | 0.94A | 4ok1A-5swuA:undetectable | 4ok1A-5swuA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tf0 | GLYCOSYL HYDROLASEFAMILY 3 N-TERMINALDOMAIN PROTEIN (Bacteroidesintestinalis) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | LEU A 77ASN A 52MET A 343ILE A 296 | None | 0.97A | 4ok1A-5tf0A:undetectable | 4ok1A-5tf0A:14.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w66 | RNA POLYMERASEI-SPECIFICTRANSCRIPTIONINITIATION FACTORRRN7 (Saccharomycescerevisiae) |
no annotation | 4 | LEU P 119LEU P 172HIS P 171ILE P 135 | None | 1.06A | 4ok1A-5w66P:undetectable | 4ok1A-5w66P:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w7k | OXAG (Penicilliumoxalicum) |
no annotation | 4 | LEU A 146MET A 108LEU A 53ILE A 35 | None | 1.03A | 4ok1A-5w7kA:undetectable | 4ok1A-5w7kA:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xnp | LEUCINE-RICH REPEATAND FIBRONECTINTYPE-IIIDOMAIN-CONTAININGPROTEIN 5 (Homo sapiens) |
no annotation | 4 | LEU A 111ASN A 133LEU A 104HIS A 105 | NoneNoneNoneSO4 A 414 ( 3.8A) | 1.04A | 4ok1A-5xnpA:undetectable | 4ok1A-5xnpA:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | RIBOSOMAL PROTEINS15AUNCHARACTERIZEDPROTEIN (Trichomonasvaginalis) |
PF00333(Ribosomal_S5)PF00410(Ribosomal_S8)PF03719(Ribosomal_S5_C) | 4 | LEU C 240ASN W 70LEU W 66ILE W 14 | None | 0.96A | 4ok1A-5xyiC:undetectable | 4ok1A-5xyiC:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b9g | ATLASTIN-1 (Homo sapiens) |
no annotation | 4 | ASN B 177MET B 87LEU B 297ILE B 213 | None | 1.00A | 4ok1A-6b9gB:undetectable | 4ok1A-6b9gB:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6by9 | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT1 (Homo sapiens) |
no annotation | 4 | LEU A 891LEU A 843HIS A 844ILE A 878 | None | 0.97A | 4ok1A-6by9A:undetectable | 4ok1A-6by9A:14.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6byo | VOLTAGE-DEPENDENTL-TYPE CALCIUMCHANNEL SUBUNITALPHA-1S (Oryctolaguscuniculus) |
no annotation | 4 | LEU A 472ASN A 468LEU A 512ILE A 524 | None | 0.99A | 4ok1A-6byoA:1.3 | 4ok1A-6byoA:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfw | MONOVALENT CATION/H+ANTIPORTER SUBUNIT D (Pyrococcusfuriosus) |
no annotation | 4 | LEU H 223MET H 328LEU H 324ILE H 257 | None | 1.05A | 4ok1A-6cfwH:undetectable | 4ok1A-6cfwH:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfz | ASK1DAD2HSK3 (Chaetomiumthermophilum) |
no annotation | 4 | ASN C 41LEU G 31HIS G 30ILE A 32 | None | 0.98A | 4ok1A-6cfzC:undetectable | 4ok1A-6cfzC:14.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cia | ALDO/KETO REDUCTASE (Klebsiellapneumoniae) |
no annotation | 4 | LEU A 144ASN A 164MET A 109ILE A 240 | NoneNoneNoneNDP A 301 (-4.7A) | 1.00A | 4ok1A-6ciaA:undetectable | 4ok1A-6ciaA:13.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f8l | - (-) |
no annotation | 4 | LEU G 439ASN G 437LEU G 412ILE G 467 | None | 1.01A | 4ok1A-6f8lG:undetectable | 4ok1A-6f8lG:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fek | PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET (Homo sapiens) |
no annotation | 4 | LEU A 816MET A 984MET A 980ILE A 890 | None | 0.84A | 4ok1A-6fekA:undetectable | 4ok1A-6fekA:13.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fj4 | ENDO-1,4-BETA-XYLANASE Y (Ruminiclostridiumthermocellum) |
no annotation | 4 | ASN A 966MET A 863LEU A 958ILE A 994 | None | 1.06A | 4ok1A-6fj4A:undetectable | 4ok1A-6fj4A:16.82 |