SIMILAR PATTERNS OF AMINO ACIDS FOR 4OJB_A_198A1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtk PORPHOBILINOGEN
DEAMINASE

(Escherichia
coli) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		5 LEU A  95
GLY A  94
LEU A  70
VAL A  79
THR A 212
 None
 1.48A 4ojbA-1gtkA:
0.0		 4ojbA-1gtkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 LEU A  64
GLY A  63
LEU A 305
MET A 142
VAL A 144
 None
 1.48A 4ojbA-1jftA:
undetectable		 4ojbA-1jftA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka8 PUTATIVE P4-SPECIFIC
DNA PRIMASE

(Enterobacteria
phage P4) 		PF03288
(Pox_D5) 		5 LEU A  63
GLY A  60
LEU A  56
MET A  23
MET A  21
 None
 1.26A 4ojbA-1ka8A:
undetectable		 4ojbA-1ka8A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 GLN B 113
LEU B  76
MET B  60
THR B  91
MET B  95
 None
 1.24A 4ojbA-1skyB:
undetectable		 4ojbA-1skyB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z47 PUTATIVE
ABC-TRANSPORTER
ATP-BINDING PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 LEU A 291
MET A 345
VAL A 347
HIS A 300
THR A 319
 None
 1.46A 4ojbA-1z47A:
undetectable		 4ojbA-1z47A:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 707
GLY A 708
GLN A 711
MET A 742
MET A 745
VAL A 746
MET A 749
ARG A 752
HIS A 874
THR A 877
MET A 895
 BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.8A)
None
BHM  A   1 (-3.0A)
None
 0.26A 4ojbA-2ax9A:
42.1		 4ojbA-2ax9A:
99.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cq1 PTB-LIKE PROTEIN L

(Homo sapiens) 		no annotation 5 LEU A  78
GLY A  79
LEU A 101
MET A 110
VAL A 111
 None
 1.34A 4ojbA-2cq1A:
undetectable		 4ojbA-2cq1A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		5 LEU A 186
LEU A 194
MET A 128
VAL A 125
HIS A 168
 None
 1.10A 4ojbA-2cybA:
undetectable		 4ojbA-2cybA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 LEU A 281
GLY A 280
VAL A 273
ARG A 363
THR A  95
 None
 1.03A 4ojbA-2de2A:
0.0		 4ojbA-2de2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 171
GLY A 172
LEU A  91
VAL A  88
THR A 144
 None
 1.20A 4ojbA-2fzwA:
undetectable		 4ojbA-2fzwA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 LEU A 530
GLY A 528
VAL A 444
HIS A 597
MET A 576
 None
 1.30A 4ojbA-2i0eA:
undetectable		 4ojbA-2i0eA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7v TLL2115 PROTEIN

(Synechococcus
elongatus) 		PF13354
(Beta-lactamase2) 		5 LEU A 177
GLY A 180
LEU A 194
MET A 232
VAL A 233
 None
 1.40A 4ojbA-2j7vA:
undetectable		 4ojbA-2j7vA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C

(Saccharomyces
cerevisiae) 		PF16796
(Microtub_bd) 		5 GLN A 384
MET A 382
VAL A 381
HIS A 453
THR A 451
 None
None
None
EDO  A 700 (-3.8A)
None
 1.44A 4ojbA-2o0aA:
undetectable		 4ojbA-2o0aA:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
 1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.8A)
 0.33A 4ojbA-2q3yA:
36.9		 4ojbA-2q3yA:
59.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfg DIHYDRODIPICOLINATE
SYNTHASE

(Hahella
chejuensis) 		PF00701
(DHDPS) 		5 LEU A 183
GLY A 200
GLN A 199
LEU A 221
MET A   1
 None
 1.45A 4ojbA-2rfgA:
undetectable		 4ojbA-2rfgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 LEU A 142
MET A 357
VAL A 358
THR A 442
MET A 175
 None
 1.27A 4ojbA-3hpaA:
undetectable		 4ojbA-3hpaA:
18.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 721
GLY A 722
GLN A 725
MET A 756
MET A 759
VAL A 760
ARG A 766
HIS A 888
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
None
 0.71A 4ojbA-3kbaA:
34.4		 4ojbA-3kbaA:
54.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 721
GLY A 722
MET A 756
MET A 759
VAL A 760
ARG A 766
HIS A 888
MET A 909
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
None
None
 1.12A 4ojbA-3kbaA:
34.4		 4ojbA-3kbaA:
54.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		6 LEU A  35
GLY A  36
GLN A  39
MET A  70
MET A  73
ARG A  80
 1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
 0.55A 4ojbA-3ry9A:
36.5		 4ojbA-3ry9A:
54.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2g ZINC-CONTAINING
ALCOHOL
DEHYDROGENASE
SUPERFAMILY

(Cupriavidus
pinatubonensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 136
LEU A 151
VAL A 290
HIS A  65
THR A 116
 None
None
FU2  A 600 (-4.4A)
ZN  A 500 ( 3.3A)
None
 1.33A 4ojbA-3s2gA:
undetectable		 4ojbA-3s2gA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 1
H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4

(Saccharomyces
cerevisiae) 		PF01472
(PUA)
PF01509
(TruB_N)
PF04410
(Gar1)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		5 LEU A 150
GLY C  83
LEU A 206
MET A 205
VAL A 201
 None
 1.19A 4ojbA-3uaiA:
undetectable		 4ojbA-3uaiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bma UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Aspergillus
fumigatus) 		PF01704
(UDPGP) 		5 GLY A 251
GLN A 408
VAL A 413
HIS A 359
THR A 275
 None
 1.25A 4ojbA-4bmaA:
undetectable		 4ojbA-4bmaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwe GLYPICAN-1

(Homo sapiens) 		PF01153
(Glypican) 		5 LEU A 227
GLY A 226
LEU A 467
MET A 297
VAL A 298
 None
 1.32A 4ojbA-4bweA:
undetectable		 4ojbA-4bweA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c23 L-FUCULOSE KINASE
FUCK

(Streptococcus
pneumoniae) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A  83
GLY A  82
VAL A  79
ARG A 101
THR A 169
 None
 1.43A 4ojbA-4c23A:
undetectable		 4ojbA-4c23A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 LEU A 631
GLY A 630
LEU A 653
VAL A 469
THR A 647
 None
 1.14A 4ojbA-4c51A:
undetectable		 4ojbA-4c51A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cke MRNA-CAPPING ENZYME
REGULATORY SUBUNIT

(Vaccinia virus) 		PF03341
(Pox_mRNA-cap) 		5 LEU B 157
LEU B  16
VAL B 197
HIS B  13
THR B  12
 None
 1.23A 4ojbA-4ckeB:
undetectable		 4ojbA-4ckeB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		5 GLY A 361
GLN A 362
LEU A 244
MET A 240
VAL A 239
 None
 1.39A 4ojbA-4fixA:
undetectable		 4ojbA-4fixA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 219
GLY A 216
MET A 277
VAL A 281
HIS A 145
 None
 1.03A 4ojbA-4l52A:
undetectable		 4ojbA-4l52A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis) 		no annotation 5 LEU A 172
GLY A 171
LEU A 122
VAL A  83
THR A 128
 None
 1.44A 4ojbA-4mfzA:
undetectable		 4ojbA-4mfzA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 LEU A 398
GLY A 397
LEU A 363
MET A 465
VAL A 463
 None
 0.98A 4ojbA-4n78A:
undetectable		 4ojbA-4n78A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 LEU A 398
GLY A 397
MET A 465
VAL A 463
HIS A 356
 None
 1.25A 4ojbA-4n78A:
undetectable		 4ojbA-4n78A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 GLY A 242
LEU A 240
MET A 170
VAL A 167
HIS A 194
 None
 1.42A 4ojbA-4ox2A:
undetectable		 4ojbA-4ox2A:
17.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 566
GLY A 567
GLN A 570
MET A 601
MET A 604
ARG A 611
 MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.2A)
 0.87A 4ojbA-4p6wA:
32.5		 4ojbA-4p6wA:
50.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE

(Roseobacter
denitrificans) 		PF03480
(DctP) 		5 LEU A 201
GLY A 208
GLN A 209
LEU A 153
MET A 168
 None
 1.44A 4ojbA-4pc9A:
undetectable		 4ojbA-4pc9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 LEU A 527
GLY A 525
VAL A 441
HIS A 594
MET A 573
 None
 1.28A 4ojbA-4ra4A:
undetectable		 4ojbA-4ra4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Rhizobium etli) 		PF01547
(SBP_bac_1) 		5 LEU A 223
GLN A 204
VAL A 394
THR A 407
MET A 403
 None
 1.29A 4ojbA-4rk2A:
undetectable		 4ojbA-4rk2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 LEU A 428
GLY A 376
LEU A 315
VAL A 370
HIS A 306
 None
 1.45A 4ojbA-4wboA:
undetectable		 4ojbA-4wboA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wut ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		5 GLY A  61
GLN A  60
MET A  74
VAL A  75
ARG A  81
 None
 1.46A 4ojbA-4wutA:
undetectable		 4ojbA-4wutA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zem TRANSLATION
INITIATION FACTOR
EIF2B-LIKE
PROTEIN,TRANSLATION
INITIATION FACTOR
EIF2B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01008
(IF-2B) 		5 LEU A 197
GLY A  47
GLN A  51
LEU A  12
ARG A  20
 None
 1.40A 4ojbA-4zemA:
undetectable		 4ojbA-4zemA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c54 DIHYDRODIPICOLINATE
SYNTHASE/N-ACETYLNEU
RAMINATE LYASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		5 LEU A 268
GLY A 267
LEU A 293
HIS A 260
THR A 258
 None
GOL  A 401 (-3.2A)
None
None
None
 1.41A 4ojbA-5c54A:
undetectable		 4ojbA-5c54A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.18A 4ojbA-5d6nA:
undetectable		 4ojbA-5d6nA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32

(Mycobacterium
marinum) 		PF00501
(AMP-binding) 		5 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.25A 4ojbA-5ey9A:
undetectable		 4ojbA-5ey9A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Bacillus cereus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 GLY A 124
LEU A 133
ARG A 215
THR A  96
MET A  12
 NAD  A 401 ( 3.5A)
None
None
NAD  A 401 (-4.0A)
NAD  A 401 (-3.5A)
 1.39A 4ojbA-5je8A:
undetectable		 4ojbA-5je8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		5 LEU A 638
GLY A 637
LEU A 660
VAL A 477
THR A 654
 None
 1.04A 4ojbA-5kqiA:
undetectable		 4ojbA-5kqiA:
14.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 GLY A 563
GLN A 566
MET A 597
MET A 600
ARG A 607
 486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
None
486  A 801 (-3.5A)
 0.72A 4ojbA-5uc1A:
22.6		 4ojbA-5uc1A:
30.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM3

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF17207
(MCM_OB) 		5 GLY 3 468
MET 3 462
VAL 3 489
MET 3 490
THR 3 432
 None
 1.49A 4ojbA-5udb3:
undetectable		 4ojbA-5udb3:
13.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  35
GLY A  36
GLN A  39
MET A  70
ARG A  80
 1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
 0.58A 4ojbA-5ufsA:
34.5		 4ojbA-5ufsA:
54.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  35
GLY A  36
GLN A  39
MET A  73
ARG A  80
 1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
 0.88A 4ojbA-5ufsA:
34.5		 4ojbA-5ufsA:
54.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03739
(YjgP_YjgQ) 		5 LEU G 285
LEU G 107
MET G 106
MET G 103
VAL G 102
 None
 1.42A 4ojbA-5x5yG:
undetectable		 4ojbA-5x5yG:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 5 GLN A 407
LEU A 380
MET A 384
ARG A 399
MET A 302
 None
 1.23A 4ojbA-5y6rA:
undetectable		 4ojbA-5y6rA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu1 LYSINE
CYCLODEAMINASE

(Streptomyces
pristinaespiralis) 		no annotation 5 LEU A 117
LEU A  23
MET A  24
HIS A 155
THR A 152
 None
 1.21A 4ojbA-5yu1A:
undetectable		 4ojbA-5yu1A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3y DENN
DOMAIN-CONTAINING
PROTEIN 3

(Mus musculus) 		no annotation 5 LEU A 917
LEU A 885
MET A 889
VAL A 890
MET A 893
 None
 1.26A 4ojbA-6b3yA:
undetectable		 4ojbA-6b3yA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzg PROTEIN ZIP2
SPORULATION-SPECIFIC
PROTEIN 16

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B 654
GLY B 655
MET A 151
VAL A 149
THR B 689
 None
 1.34A 4ojbA-6bzgB:
undetectable		 4ojbA-6bzgB:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f7c RHOGAP PROTEIN

(Gallus gallus) 		PF00620
(RhoGAP) 		4 LEU A 319
ILE A 297
ILE A 375
VAL A 301
 None
 0.84A 4ojbA-1f7cA:
0.0		 4ojbA-1f7cA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  33
ILE A  54
ILE A  47
VAL A  56
 None
None
A79  A 800 ( 3.2A)
None
 0.83A 4ojbA-1hvcA:
undetectable		 4ojbA-1hvcA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im8 YECO

(Haemophilus
influenzae) 		PF13649
(Methyltransf_25) 		4 LEU A  62
LEU A 159
ILE A  41
ILE A  45
 None
 0.87A 4ojbA-1im8A:
undetectable		 4ojbA-1im8A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A 196
ILE A 243
ILE A 171
VAL A 241
 None
 0.77A 4ojbA-1p43A:
undetectable		 4ojbA-1p43A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q14 HST2 PROTEIN

(Saccharomyces
cerevisiae) 		PF02146
(SIR2) 		4 LEU A 102
MET A  19
LEU A 277
ILE A  35
 None
 0.86A 4ojbA-1q14A:
undetectable		 4ojbA-1q14A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qap QUINOLINIC ACID
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 LEU A 255
LEU A 225
ILE A 184
VAL A 195
 None
 0.86A 4ojbA-1qapA:
0.7		 4ojbA-1qapA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 LEU A  77
ILE A 118
ILE A 120
VAL A  43
 None
 0.87A 4ojbA-1qdlA:
0.0		 4ojbA-1qdlA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rax PROTEIN (RA-DOMAIN
OF RAL GUANOSINE
DISSOCIATION
STIMULATOR)

(Homo sapiens) 		PF00788
(RA) 		4 LEU A  78
ILE A  46
ILE A  31
VAL A  48
 None
 0.75A 4ojbA-1raxA:
undetectable		 4ojbA-1raxA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ton TONIN

(Rattus rattus) 		PF00089
(Trypsin) 		4 LEU A 199
ILE A  47
ILE A 121
VAL A  45
 None
 0.80A 4ojbA-1tonA:
undetectable		 4ojbA-1tonA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u39 AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING,
FAMILY A, MEMBER 1

(Homo sapiens) 		PF00595
(PDZ) 		4 LEU A  85
ILE A 125
ILE A 124
VAL A 132
 None
 0.68A 4ojbA-1u39A:
undetectable		 4ojbA-1u39A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE

(Thermus
thermophilus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A  59
ASN A  58
LEU A 102
ILE A  79
VAL A  41
 None
 1.44A 4ojbA-1uekA:
undetectable		 4ojbA-1uekA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukv GTP-BINDING PROTEIN
YPT1

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		4 ASN Y  16
MET Y 145
LEU Y 103
ILE Y  73
 None
 0.82A 4ojbA-1ukvY:
undetectable		 4ojbA-1ukvY:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vph HYPOTHETICAL PROTEIN
SSO2532

(Sulfolobus
solfataricus) 		PF01894
(UPF0047) 		4 LEU A  40
ILE A  21
ILE A 116
VAL A  25
 None
 0.64A 4ojbA-1vphA:
undetectable		 4ojbA-1vphA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		4 LEU A  25
ILE A  35
ILE A  11
VAL A  33
 None
 0.78A 4ojbA-1xkqA:
undetectable		 4ojbA-1xkqA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		4 LEU A 222
LEU A 210
ILE A 195
ILE A 196
 None
1PE  A 601 ( 4.4A)
None
None
 0.62A 4ojbA-1xviA:
undetectable		 4ojbA-1xviA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7n AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY A MEMBER 1

(Homo sapiens) 		PF00595
(PDZ) 		4 LEU A  16
ILE A  56
ILE A  55
VAL A  63
 None
 0.47A 4ojbA-1y7nA:
undetectable		 4ojbA-1y7nA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwx SPHINGOMYELINASE-C

(Listeria
ivanovii) 		PF03372
(Exo_endo_phos) 		4 LEU A 102
ILE A 172
ILE A 145
VAL A 170
 None
 0.82A 4ojbA-1zwxA:
undetectable		 4ojbA-1zwxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA

(Mycobacterium
tuberculosis) 		PF13184
(KH_5) 		4 LEU A 195
LEU A 188
ILE A 207
VAL A 210
 None
 0.78A 4ojbA-2asbA:
undetectable		 4ojbA-2asbA:
18.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 704
ASN A 705
MET A 787
LEU A 873
ILE A 898
ILE A 899
VAL A 903
 BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.4A)
None
None
None
 0.52A 4ojbA-2ax9A:
42.1		 4ojbA-2ax9A:
99.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdq COPPER HOMEOSTASIS
PROTEIN CUTC

(Streptococcus
agalactiae) 		PF03932
(CutC) 		4 LEU A  11
ILE A  22
ILE A  55
VAL A  25
 None
 0.83A 4ojbA-2bdqA:
undetectable		 4ojbA-2bdqA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9x DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2

(Homo sapiens) 		PF05916
(Sld5) 		4 LEU B  23
ILE B  18
ILE B  17
VAL B  42
 None
 0.86A 4ojbA-2e9xB:
undetectable		 4ojbA-2e9xB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f91 HEPATOPANCREAS
TRYPSIN

(Astacus
leptodactylus) 		PF00089
(Trypsin) 		4 LEU A  31
ILE A 103
ILE A 212
VAL A 232
 None
 0.86A 4ojbA-2f91A:
undetectable		 4ojbA-2f91A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gre DEBLOCKING
AMINOPEPTIDASE

(Bacillus cereus) 		PF05343
(Peptidase_M42) 		4 LEU A  15
ILE A 174
ILE A 180
VAL A 172
 None
 0.78A 4ojbA-2greA:
undetectable		 4ojbA-2greA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4n PROLINE-TRNA LIGASE

(Rhodopseudomonas
palustris) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 LEU A  11
LEU A  43
ILE A 337
ILE A 397
 None
 0.87A 4ojbA-2i4nA:
undetectable		 4ojbA-2i4nA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inr DNA TOPOISOMERASE 4
SUBUNIT A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV) 		4 LEU A 276
ILE A 299
ILE A 301
VAL A 288
 None
 0.77A 4ojbA-2inrA:
undetectable		 4ojbA-2inrA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jre C60-1 PDZ DOMAIN
PEPTIDE

(-) 		PF00595
(PDZ) 		4 LEU A  27
ILE A  46
ILE A  69
VAL A  48
 None
 0.86A 4ojbA-2jreA:
undetectable		 4ojbA-2jreA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kij COPPER-TRANSPORTING
ATPASE 1

(Homo sapiens) 		PF00122
(E1-E2_ATPase) 		4 LEU A 108
ILE A  43
ILE A  97
VAL A  45
 None
 0.85A 4ojbA-2kijA:
undetectable		 4ojbA-2kijA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mri 26S PROTEASOME
REGULATORY SUBUNIT
RPN9

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 LEU A 334
LEU A 327
ILE A 350
VAL A 348
 None
 0.86A 4ojbA-2mriA:
undetectable		 4ojbA-2mriA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6c AQ_2013 PROTEIN

(Aquifex
aeolicus) 		PF01894
(UPF0047) 		4 LEU A  40
ILE A  21
ILE A 117
VAL A  25
 None
 0.68A 4ojbA-2p6cA:
undetectable		 4ojbA-2p6cA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A1136
ILE A1115
ILE A1095
VAL A1113
 None
 0.86A 4ojbA-2qf7A:
undetectable		 4ojbA-2qf7A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rs5 HUMAN RHINOVIRUS 14
COAT PROTEIN
(SUBUNIT VP2)

(Rhinovirus B) 		PF00073
(Rhv) 		4 LEU 2 181
ILE 2 201
ILE 2 199
VAL 2 108
 None
 0.71A 4ojbA-2rs52:
undetectable		 4ojbA-2rs52:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 LEU A 507
ILE A 465
ILE A 468
VAL A 486
 None
 0.81A 4ojbA-2vxoA:
undetectable		 4ojbA-2vxoA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkk TOPOISOMERASE IV

(Acinetobacter
baumannii) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 LEU A1325
ILE A1225
ILE A1226
VAL A1485
 None
 0.73A 4ojbA-2xkkA:
undetectable		 4ojbA-2xkkA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zle PROTEASE DO

(Escherichia
coli) 		PF00595
(PDZ)
PF13365
(Trypsin_2) 		4 LEU A 169
ILE A  56
ILE A 113
VAL A  54
 None
 0.85A 4ojbA-2zleA:
undetectable		 4ojbA-2zleA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrobaculum
aerophilum) 		PF07995
(GSDH) 		4 MET A 228
ILE A 146
ILE A 143
VAL A 124
 None
 0.85A 4ojbA-3a9gA:
undetectable		 4ojbA-3a9gA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bji PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF) 		4 ASN A 448
LEU A 427
ILE A 503
ILE A 506
 None
 0.66A 4ojbA-3bjiA:
undetectable		 4ojbA-3bjiA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 MET A 371
LEU A 330
ILE A  46
VAL A   2
 None
 0.78A 4ojbA-3cinA:
undetectable		 4ojbA-3cinA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do5 HOMOSERINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 LEU A  19
ILE A   2
ILE A   4
VAL A  82
 None
 0.75A 4ojbA-3do5A:
undetectable		 4ojbA-3do5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efb PROBABLE SOR-OPERON
REGULATOR

(Shigella
flexneri) 		PF04198
(Sugar-bind) 		4 LEU A  47
ILE A 229
ILE A 231
VAL A 254
 None
 0.78A 4ojbA-3efbA:
undetectable		 4ojbA-3efbA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib6 UNCHARACTERIZED
PROTEIN

(Listeria
monocytogenes) 		PF13419
(HAD_2) 		4 LEU A  48
ILE A 161
ILE A 138
VAL A 163
 None
 0.79A 4ojbA-3ib6A:
undetectable		 4ojbA-3ib6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js3 3-DEHYDROQUINATE
DEHYDRATASE

(Clostridioides
difficile) 		PF01487
(DHquinase_I) 		4 LEU A  78
ILE A  12
ILE A  10
VAL A   7
 None
 0.83A 4ojbA-3js3A:
undetectable		 4ojbA-3js3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k33 DEATH ON CURING
PROTEIN

(Escherichia
virus P1) 		PF02661
(Fic) 		4 LEU A  59
ILE A  35
ILE A  36
VAL A  39
 None
 0.71A 4ojbA-3k33A:
undetectable		 4ojbA-3k33A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh0 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR

(Homo sapiens) 		PF00788
(RA) 		4 LEU A 849
ILE A 817
ILE A 802
VAL A 819
 None
UNX  A   1 ( 4.0A)
None
None
 0.69A 4ojbA-3kh0A:
undetectable		 4ojbA-3kh0A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwl UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 4 LEU A 294
ILE A 328
ILE A 329
VAL A 332
 None
 0.84A 4ojbA-3kwlA:
undetectable		 4ojbA-3kwlA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky9 PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF)
PF11971
(CAMSAP_CH) 		4 ASN A 448
LEU A 427
ILE A 503
ILE A 506
 None
 0.76A 4ojbA-3ky9A:
undetectable		 4ojbA-3ky9A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnb N-ACETYLTRANSFERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00797
(Acetyltransf_2) 		4 LEU A  80
MET A  32
ILE A 196
VAL A 201
 None
 0.80A 4ojbA-3lnbA:
undetectable		 4ojbA-3lnbA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpl VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		4 LEU A 346
ILE A 351
ILE A 350
VAL A 313
 None
 0.86A 4ojbA-3mplA:
undetectable		 4ojbA-3mplA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia pestis) 		PF04095
(NAPRTase) 		4 LEU A 154
ASN A 158
LEU A 171
ILE A 166
 None
 0.81A 4ojbA-3os4A:
undetectable		 4ojbA-3os4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		4 LEU B1012
ILE B1028
ILE B1029
VAL B1032
 None
 0.78A 4ojbA-3qd2B:
undetectable		 4ojbA-3qd2B:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr8 BASEPLATE ASSEMBLY
PROTEIN V

(Escherichia
virus P2) 		PF04717
(Phage_base_V) 		4 LEU A  82
ILE A  22
ILE A  23
VAL A  35
 None
 0.78A 4ojbA-3qr8A:
undetectable		 4ojbA-3qr8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR2

(Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA) 		4 ASN B 211
LEU B  55
ILE B 214
VAL B 216
 None
 0.84A 4ojbA-3r7wB:
undetectable		 4ojbA-3r7wB:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhg PUTATIVE
PHOPHOTRIESTERASE

(Proteus
mirabilis) 		PF02126
(PTE) 		4 ASN A 337
LEU A 280
ILE A 330
ILE A 329
 None
 0.83A 4ojbA-3rhgA:
undetectable		 4ojbA-3rhgA:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		4 ASN A  33
LEU A 201
ILE A 226
ILE A 227
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.2A)
None
None
 0.45A 4ojbA-3ry9A:
36.5		 4ojbA-3ry9A:
54.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		4 LEU A  32
ASN A  33
ILE A 226
ILE A 227
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
None
None
 0.51A 4ojbA-3ry9A:
36.5		 4ojbA-3ry9A:
54.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sp1 CYSTEINYL-TRNA
SYNTHETASE

(Borreliella
burgdorferi) 		PF01406
(tRNA-synt_1e) 		4 LEU A   5
ASN A   7
LEU A 237
ILE A 243
 None
 0.82A 4ojbA-3sp1A:
undetectable		 4ojbA-3sp1A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sti PROTEASE DEGQ

(Escherichia
coli) 		PF13365
(Trypsin_2) 		4 LEU A 191
ILE A  70
ILE A 127
VAL A  68
 None
 0.75A 4ojbA-3stiA:
undetectable		 4ojbA-3stiA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tuf STAGE III
SPORULATION PROTEIN
AH

(Bacillus
subtilis) 		PF12685
(SpoIIIAH) 		4 LEU A 161
ILE A 179
ILE A 181
VAL A 172
 None
 0.80A 4ojbA-3tufA:
undetectable		 4ojbA-3tufA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1t DMMA HALOALKANE
DEHALOGENASE

(unidentified) 		PF00561
(Abhydrolase_1) 		4 LEU A  73
ILE A  88
ILE A  89
VAL A  92
 None
 0.77A 4ojbA-3u1tA:
undetectable		 4ojbA-3u1tA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uau SURFACE-EXPOSED
LIPOPROTEIN

(Campylobacter
jejuni) 		PF16668
(JLPA) 		4 LEU A 187
ILE A 257
ILE A 256
VAL A 329
 None
 0.83A 4ojbA-3uauA:
undetectable		 4ojbA-3uauA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnf MEMBRANE-ASSOCIATED
PROTEIN VP24

(Sudan
ebolavirus) 		PF06389
(Filo_VP24) 		4 LEU A  94
ILE A 188
ILE A 190
VAL A 199
 None
 0.83A 4ojbA-3vnfA:
undetectable		 4ojbA-3vnfA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac3 BIFUNCTIONAL PROTEIN
GLMU

(Streptococcus
pneumoniae) 		PF00132
(Hexapep)
PF00483
(NTP_transferase)
PF14602
(Hexapep_2) 		4 LEU A 128
LEU A  97
ILE A 198
VAL A  82
 None
 0.77A 4ojbA-4ac3A:
undetectable		 4ojbA-4ac3A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE

(Pseudogluconobacter
saccharoketogenes) 		PF13360
(PQQ_2) 		4 LEU A 281
ILE A 207
ILE A 214
VAL A 209
 None
 0.77A 4ojbA-4cvcA:
undetectable		 4ojbA-4cvcA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE

(Corynebacterium
glutamicum) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		4 LEU A  55
LEU A  59
ILE A 145
VAL A 233
 None
 0.85A 4ojbA-4dbhA:
undetectable		 4ojbA-4dbhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djf CORRINOID/IRON-SULFU
R PROTEIN LARGE
SUBUNIT

(Moorella
thermoacetica) 		PF03599
(CdhD)
PF04060
(FeS) 		4 ASN C 115
ILE C  96
ILE C 131
VAL C  98
 None
 0.83A 4ojbA-4djfC:
undetectable		 4ojbA-4djfC:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4r PHOSPHATE
ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF01515
(PTA_PTB) 		4 ASN A 304
LEU A   8
ILE A  19
VAL A  42
 None
 0.86A 4ojbA-4e4rA:
undetectable		 4ojbA-4e4rA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eg9 UNCHARACTERIZED
PROTEIN
SAOUHSC_02783

(Staphylococcus
aureus) 		PF04507
(DUF576) 		4 ASN A 136
ILE A 139
ILE A 138
VAL A 131
 None
 0.86A 4ojbA-4eg9A:
undetectable		 4ojbA-4eg9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 149
LEU A 181
ILE A 165
VAL A 187
 None
EDO  A 406 ( 4.4A)
None
None
 0.84A 4ojbA-4ej6A:
undetectable		 4ojbA-4ej6A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd6 ARYLALKYLAMINE
N-ACETYLTRANSFERASE
2

(Aedes aegypti) 		PF00583
(Acetyltransf_1) 		4 LEU A  80
ASN A  81
ILE A 152
VAL A 179
 None
 0.86A 4ojbA-4fd6A:
undetectable		 4ojbA-4fd6A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		4 LEU A 124
ILE A 153
ILE A 154
VAL A 157
 None
 0.75A 4ojbA-4gbrA:
undetectable		 4ojbA-4gbrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdz SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C)
PF17210
(SdrD_B) 		4 LEU A 328
ILE A 302
ILE A 305
VAL A 294
 None
 0.86A 4ojbA-4jdzA:
undetectable		 4ojbA-4jdzA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpo NUCLEOSIDE
N-RIBOHYDROLASE 3

(Zea mays) 		PF01156
(IU_nuc_hydro) 		4 LEU A 149
ILE A   4
ILE A   3
VAL A  28
 None
 0.81A 4ojbA-4kpoA:
undetectable		 4ojbA-4kpoA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Thermomonospora
curvata) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		4 LEU A 253
ILE A  15
ILE A 227
VAL A  13
 None
 0.75A 4ojbA-4lrsA:
undetectable		 4ojbA-4lrsA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mp3 PUTATIVE ORNITHINE
CYCLODEAMINASE

(Staphylococcus
aureus) 		PF02423
(OCD_Mu_crystall) 		4 LEU A 149
ILE A 145
ILE A 144
VAL A 170
 GOL  A 402 (-3.8A)
None
None
None
 0.84A 4ojbA-4mp3A:
undetectable		 4ojbA-4mp3A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muo UNCHARACTERIZED
PROTEIN YBIB

(Escherichia
coli) 		PF02885
(Glycos_trans_3N) 		4 LEU A  97
LEU A 104
ILE A  85
VAL A 112
 None
 0.60A 4ojbA-4muoA:
undetectable		 4ojbA-4muoA:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ASN A 564
LEU A 732
ILE A 756
ILE A 757
 MOF  A 801 (-3.0A)
MOF  A 801 ( 4.2A)
None
None
 0.41A 4ojbA-4p6wA:
32.5		 4ojbA-4p6wA:
50.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0c VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		4 LEU A 346
ILE A 351
ILE A 350
VAL A 313
 None
 0.84A 4ojbA-4q0cA:
undetectable		 4ojbA-4q0cA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		4 ASN A 684
ILE A 194
ILE A 195
VAL A 198
 None
 0.87A 4ojbA-4u1rA:
undetectable		 4ojbA-4u1rA:
15.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ASN A 770
LEU A 938
ILE A 963
ILE A 964
 CV7  A1987 (-3.1A)
CV7  A1987 ( 3.9A)
None
None
 0.60A 4ojbA-4udbA:
33.3		 4ojbA-4udbA:
52.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		4 LEU A 662
ILE A 614
ILE A 615
VAL A 618
 None
 0.78A 4ojbA-4uvkA:
undetectable		 4ojbA-4uvkA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		4 LEU A 161
ILE A  52
ILE A 137
VAL A  54
 None
 0.81A 4ojbA-4xjxA:
undetectable		 4ojbA-4xjxA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynn PROTEASE DO

(Legionella
pneumophila) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 LEU A 434
ILE A 396
ILE A 395
VAL A 403
 None
 0.73A 4ojbA-4ynnA:
undetectable		 4ojbA-4ynnA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ASN A 391
ILE A 375
ILE A 397
VAL A 377
 None
 0.82A 4ojbA-4ypjA:
undetectable		 4ojbA-4ypjA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 LEU A 468
LEU A 441
ILE A 494
VAL A 496
 None
 0.81A 4ojbA-4z64A:
undetectable		 4ojbA-4z64A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 LEU A 856
ILE A 681
ILE A 683
VAL A 701
 None
 0.85A 4ojbA-5azaA:
undetectable		 4ojbA-5azaA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5emi CELL WALL
HYDROLASE/AUTOLYSIN

(Nostoc
punctiforme) 		PF01520
(Amidase_3) 		4 LEU A 576
ILE A 547
ILE A 604
VAL A 543
 MES  A 704 (-4.9A)
None
None
None
 0.83A 4ojbA-5emiA:
undetectable		 4ojbA-5emiA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwt SENSOR HISTIDINE
KINASE TODS

(Pseudomonas
putida) 		PF08448
(PAS_4) 		4 LEU A  64
ILE A 124
ILE A 114
VAL A 126
 None
 0.83A 4ojbA-5hwtA:
undetectable		 4ojbA-5hwtA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxs SODIUM,CALCIUM
EXCHANGER

(Methanocaldococcus
jannaschii) 		PF01699
(Na_Ca_ex) 		4 LEU A 269
LEU A 106
ILE A 238
ILE A 234
 None
 0.81A 4ojbA-5hxsA:
undetectable		 4ojbA-5hxsA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 LEU A 776
ILE A 829
ILE A 784
VAL A 827
 None
 0.76A 4ojbA-5hzvA:
undetectable		 4ojbA-5hzvA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixx ALR2278 PROTEIN

(Nostoc sp. PCC
7120) 		PF07700
(HNOB) 		4 LEU A 101
LEU A 148
ILE A 179
VAL A 162
 HEM  A 201 (-4.8A)
HEM  A 201 ( 3.4A)
None
None
 0.80A 4ojbA-5ixxA:
undetectable		 4ojbA-5ixxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 ASN A 770
MET A 852
LEU A 938
ILE A 963
ILE A 964
 ECV  A1101 (-3.1A)
ECV  A1101 (-3.7A)
ECV  A1101 ( 4.3A)
None
None
 0.76A 4ojbA-5mwpA:
36.8		 4ojbA-5mwpA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 4 LEU A 769
ASN A 770
ILE A 963
ILE A 964
 ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
None
None
 0.54A 4ojbA-5mwpA:
36.8		 4ojbA-5mwpA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nag KYNURENINE
3-MONOOXYGENASE

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		4 LEU A 114
ASN A 115
LEU A  21
ILE A 129
 None
 0.87A 4ojbA-5nagA:
undetectable		 4ojbA-5nagA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 4 ASN A1284
ILE A1214
ILE A1213
VAL A1195
 None
 0.85A 4ojbA-5ngyA:
undetectable		 4ojbA-5ngyA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0z LIPOPROTEIN,
PUTATIVE

(Geobacter
metallireducens) 		no annotation 4 LEU A  39
LEU A 133
ILE A 136
VAL A 143
 None
 0.86A 4ojbA-5t0zA:
undetectable		 4ojbA-5t0zA:
19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		4 ASN A  33
LEU A 201
ILE A 225
ILE A 226
 1TA  A 301 (-3.0A)
1TA  A 301 ( 3.8A)
None
None
 0.59A 4ojbA-5ufsA:
34.5		 4ojbA-5ufsA:
54.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7k OXAG

(Penicillium
oxalicum) 		no annotation 4 LEU A 120
MET A 108
LEU A  53
ILE A  35
 None
 0.80A 4ojbA-5w7kA:
undetectable		 4ojbA-5w7kA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE

(Streptococcus
pneumoniae) 		no annotation 4 LEU A  62
ILE A 353
ILE A 357
VAL A  66
 None
 0.86A 4ojbA-5wpkA:
undetectable		 4ojbA-5wpkA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y28 -

(-) 		no annotation 4 LEU A 225
ILE A 105
ILE A 161
VAL A 103
 None
 0.87A 4ojbA-5y28A:
undetectable		 4ojbA-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brm PUTATIVE
METAL-DEPENDENT
ISOTHIOCYANATE
HYDROLASE SAXA

(Pectobacterium
carotovorum) 		no annotation 4 LEU A  21
ILE A 159
ILE A 161
VAL A 184
 None
 0.74A 4ojbA-6brmA:
undetectable		 4ojbA-6brmA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft -

(-) 		no annotation 4 LEU A 370
LEU A 113
ILE A 319
VAL A 317
 None
 0.73A 4ojbA-6dftA:
undetectable		 4ojbA-6dftA:
undetectable