SIMILAR PATTERNS OF AMINO ACIDS FOR 4OJ4_A_DIFA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwp COAT PROTEIN

(Cowpea
chlorotic
mottle virus) 		PF01318
(Bromo_coat) 		4 LEU A  93
LEU A 173
VAL A 171
ILE A  70
 None
 0.71A 4oj4A-1cwpA:
0.0		 4oj4A-1cwpA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 4 LEU B 362
LEU B 359
VAL B 358
ILE B 952
 None
 0.89A 4oj4A-1ej6B:
1.5		 4oj4A-1ej6B:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eke RIBONUCLEASE HII

(Methanocaldococcus
jannaschii) 		PF01351
(RNase_HII) 		4 LEU A  33
LEU A  36
VAL A  38
ILE A 160
 None
 0.92A 4oj4A-1ekeA:
0.0		 4oj4A-1ekeA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fkm PROTEIN (GYP1P)

(Saccharomyces
cerevisiae) 		PF00566
(RabGAP-TBC) 		4 LEU A 454
LEU A 457
VAL A 458
ILE A 584
 None
 0.77A 4oj4A-1fkmA:
0.0		 4oj4A-1fkmA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6g PROTEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		PF00498
(FHA) 		4 LEU A  78
LEU A 141
VAL A 132
ILE A 130
 None
 0.94A 4oj4A-1g6gA:
0.0		 4oj4A-1g6gA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 LEU A  26
LEU A  23
VAL A  22
ILE A 289
 None
 0.95A 4oj4A-1idmA:
0.0		 4oj4A-1idmA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE

(Rattus
norvegicus) 		PF00459
(Inositol_P) 		5 SER A  14
LEU A  62
LEU A  69
VAL A 114
ILE A 139
 None
 1.40A 4oj4A-1jp4A:
0.0		 4oj4A-1jp4A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mnn NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		4 LEU A 148
LEU A 137
VAL A 139
ILE A 295
 None
 0.82A 4oj4A-1mnnA:
0.0		 4oj4A-1mnnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbu PROBABLE
DIHYDRONEOPTERIN
ALDOLASE

(Mycobacterium
tuberculosis) 		PF02152
(FolB) 		4 LEU B  57
LEU B   7
VAL B  33
ILE B  31
 None
 0.88A 4oj4A-1nbuB:
0.0		 4oj4A-1nbuB:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nij HYPOTHETICAL PROTEIN
YJIA

(Escherichia
coli) 		PF02492
(cobW)
PF07683
(CobW_C) 		5 LEU A 169
LEU A 157
VAL A 130
ILE A 155
MET A 139
 None
 1.15A 4oj4A-1nijA:
undetectable		 4oj4A-1nijA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnh ASPARAGINYL-TRNA
SYNTHETASE-RELATED
PEPTIDE

(Pyrococcus
furiosus) 		PF00152
(tRNA-synt_2) 		4 LEU A  94
LEU A 117
VAL A 265
ILE A  21
 None
 0.90A 4oj4A-1nnhA:
undetectable		 4oj4A-1nnhA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osn THYMIDINE KINASE

(Human
alphaherpesvirus
3) 		PF00693
(Herpes_TK) 		4 LEU A 329
LEU A 332
VAL A 333
MET A 126
 None
 0.90A 4oj4A-1osnA:
undetectable		 4oj4A-1osnA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE

(Enterobacter
cloacae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 214
LEU A 281
VAL A 283
ILE A 328
 None
 0.85A 4oj4A-1ovmA:
undetectable		 4oj4A-1ovmA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q7s BIT1

(Homo sapiens) 		PF01981
(PTH2) 		4 LEU A 129
LEU A 159
VAL A  70
ILE A  68
 None
 0.93A 4oj4A-1q7sA:
undetectable		 4oj4A-1q7sA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Escherichia
coli) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		5 LEU A 124
LEU A 234
VAL A 206
ILE A 236
MET A 175
 None
 1.25A 4oj4A-1sc6A:
undetectable		 4oj4A-1sc6A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szq 2-METHYLCITRATE
DEHYDRATASE

(Escherichia
coli) 		PF03972
(MmgE_PrpD) 		4 SER A 463
LEU A  41
LEU A 145
VAL A 144
 None
 0.82A 4oj4A-1szqA:
undetectable		 4oj4A-1szqA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6r PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1442

(Thermotoga
maritima) 		PF01740
(STAS) 		4 LEU A  62
LEU A  65
VAL A  66
ILE A 100
 SEP  A  59 ( 3.9A)
None
None
None
 0.86A 4oj4A-1t6rA:
undetectable		 4oj4A-1t6rA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5t VPS36P
DEFECTIVE IN
VACUOLAR PROTEIN
SORTING

(Saccharomyces
cerevisiae) 		PF04157
(EAP30) 		4 LEU B 475
VAL B 487
ILE B 435
MET B 460
 None
 0.76A 4oj4A-1u5tB:
undetectable		 4oj4A-1u5tB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9k RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE C

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		4 LEU A 105
LEU A 151
VAL A 153
ILE A 124
 None
 0.95A 4oj4A-1v9kA:
undetectable		 4oj4A-1v9kA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT
IRON-SULFUR PROTEIN
LARGE SUBUNIT OF
CUMENE DIOXYGENASE

(Pseudomonas
fluorescens) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
PF00866
(Ring_hydroxyl_B) 		4 SER B 183
VAL A 393
ILE A 217
MET B 142
 None
 0.96A 4oj4A-1wqlB:
undetectable		 4oj4A-1wqlB:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wr8 PHOSPHOGLYCOLATE
PHOSPHATASE

(Pyrococcus
horikoshii) 		PF08282
(Hydrolase_3) 		4 LEU A  89
LEU A 113
VAL A 147
ILE A 145
 None
 0.86A 4oj4A-1wr8A:
undetectable		 4oj4A-1wr8A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE

(Chlorobaculum
tepidum) 		PF04371
(PAD_porph) 		4 LEU A 169
VAL A 230
ILE A 232
MET A 256
 None
 0.87A 4oj4A-1xknA:
undetectable		 4oj4A-1xknA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvx YFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 SER A 277
LEU A 284
LEU A 287
VAL A 228
 None
None
None
EDO  A 321 (-4.5A)
 0.96A 4oj4A-1xvxA:
undetectable		 4oj4A-1xvxA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvy SFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 SER A 274
LEU A 281
LEU A 284
VAL A 225
 None
 0.93A 4oj4A-1xvyA:
undetectable		 4oj4A-1xvyA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Staphylococcus
aureus) 		PF04131
(NanE) 		4 LEU A 105
LEU A 108
VAL A 109
ILE A 121
 None
 0.88A 4oj4A-1y0eA:
undetectable		 4oj4A-1y0eA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A  94
VAL A 139
ILE A 176
MET A  85
 None
 0.87A 4oj4A-1y4uA:
undetectable		 4oj4A-1y4uA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y51 PHOSPHOCARRIER
PROTEIN HPR

(Geobacillus
stearothermophilus) 		PF00381
(PTS-HPr) 		4 LEU A  81
LEU A  86
VAL A   8
ILE A  55
 None
 0.96A 4oj4A-1y51A:
undetectable		 4oj4A-1y51A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A 222
LEU A 221
VAL A 130
ILE A 164
 None
 0.96A 4oj4A-1ys4A:
undetectable		 4oj4A-1ys4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywq NITROREDUCTASE
FAMILY PROTEIN

(Bacillus cereus) 		PF00881
(Nitroreductase) 		4 LEU A  56
LEU A  99
VAL A  54
ILE A 166
 None
 0.95A 4oj4A-1ywqA:
undetectable		 4oj4A-1ywqA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1za7 COAT PROTEIN

(Cowpea
chlorotic
mottle virus) 		PF01318
(Bromo_coat) 		4 LEU A  93
LEU A 173
VAL A 171
ILE A  70
 None
 0.86A 4oj4A-1za7A:
undetectable		 4oj4A-1za7A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgz TORCAD OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
TORR

(Escherichia
coli) 		PF00072
(Response_reg) 		4 LEU A  49
VAL A  74
ILE A  76
MET A  42
 None
 0.93A 4oj4A-1zgzA:
undetectable		 4oj4A-1zgzA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY

(Thermotoga
maritima) 		PF00294
(PfkB) 		4 LEU A 132
LEU A   3
VAL A 138
ILE A 140
 None
 0.86A 4oj4A-2ajrA:
undetectable		 4oj4A-2ajrA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dos ATAXIN-3

(Homo sapiens) 		PF02099
(Josephin) 		4 CYH A  18
LEU A  84
LEU A  89
VAL A 165
 None
 0.92A 4oj4A-2dosA:
undetectable		 4oj4A-2dosA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7j SEP-TRNA:CYS-TRNA
SYNTHASE

(Archaeoglobus
fulgidus) 		PF05889
(SepSecS) 		5 SER A 105
LEU A 152
VAL A  96
ILE A 117
MET A  86
 PLP  A1209 (-3.5A)
None
None
None
None
 1.35A 4oj4A-2e7jA:
undetectable		 4oj4A-2e7jA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fez PROBABLE REGULATORY
PROTEIN EMBR

(Mycobacterium
tuberculosis) 		PF00486
(Trans_reg_C)
PF00498
(FHA)
PF03704
(BTAD) 		4 LEU A  39
LEU A  42
VAL A  43
ILE A 105
 None
 0.90A 4oj4A-2fezA:
undetectable		 4oj4A-2fezA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyi HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CBL

(Escherichia
coli) 		PF03466
(LysR_substrate) 		4 SER A 182
LEU A 259
LEU A 170
VAL A 172
 None
 0.86A 4oj4A-2fyiA:
undetectable		 4oj4A-2fyiA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Sulfurisphaera
tokodaii) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		4 SER A 153
LEU A 135
LEU A 141
VAL A 199
 None
 0.94A 4oj4A-2ggqA:
undetectable		 4oj4A-2ggqA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hku A PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF16914
(TetR_C_12) 		4 SER A  60
LEU A 125
LEU A 128
MET A 118
 None
 0.87A 4oj4A-2hkuA:
undetectable		 4oj4A-2hkuA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ie8 PHOSPHOGLYCERATE
KINASE

(Thermus
caldophilus) 		PF00162
(PGK) 		4 SER A  93
LEU A 111
LEU A  55
VAL A  53
 None
 0.96A 4oj4A-2ie8A:
undetectable		 4oj4A-2ie8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2khi 30S RIBOSOMAL
PROTEIN S1

(Escherichia
coli) 		PF00575
(S1) 		4 LEU A 280
LEU A 344
VAL A 332
ILE A 335
 None
 0.95A 4oj4A-2khiA:
undetectable		 4oj4A-2khiA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00497
(SBP_bac_3) 		4 LEU A 206
VAL A   6
ILE A   8
MET A  41
 None
 0.82A 4oj4A-2laoA:
undetectable		 4oj4A-2laoA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ml8 FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 151
LEU A 154
VAL A 155
ILE A 186
 None
 0.83A 4oj4A-2ml8A:
undetectable		 4oj4A-2ml8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mv7 HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		no annotation 4 LEU B 890
LEU B 885
VAL B 888
ILE B 883
 None
 0.79A 4oj4A-2mv7B:
undetectable		 4oj4A-2mv7B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n5d FUSION PROTEIN OF
TWO PKS DOMAINS

(Streptomyces
virginiae) 		no annotation 4 LEU A  19
LEU A  28
VAL A  23
ILE A  30
 None
 0.85A 4oj4A-2n5dA:
undetectable		 4oj4A-2n5dA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt4 RESPONSE REGULATOR
HOMOLOG

(Myxococcus
xanthus) 		PF00072
(Response_reg) 		4 SER A  38
LEU A  69
LEU A  75
VAL A  78
 None
 0.96A 4oj4A-2nt4A:
undetectable		 4oj4A-2nt4A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1v ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 163
VAL A 211
ILE A 247
MET A 154
 None
None
None
ADP  A 301 (-3.6A)
 0.89A 4oj4A-2o1vA:
undetectable		 4oj4A-2o1vA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1w ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 163
VAL A 211
ILE A 247
MET A 154
 None
 0.94A 4oj4A-2o1wA:
undetectable		 4oj4A-2o1wA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		4 LEU A  62
LEU A  65
VAL A  66
MET A  91
 None
 0.95A 4oj4A-2oy0A:
undetectable		 4oj4A-2oy0A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6r AFUHEL308 HELICASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 505
LEU A 500
VAL A 499
ILE A 495
 None
 0.87A 4oj4A-2p6rA:
undetectable		 4oj4A-2p6rA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcn S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE

(Geobacillus
kaustophilus) 		PF03737
(RraA-like) 		4 LEU A  52
LEU A  61
VAL A  90
ILE A  92
 None
 0.86A 4oj4A-2pcnA:
undetectable		 4oj4A-2pcnA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qip PROTEIN OF UNKNOWN
FUNCTION VPA0982

(Vibrio
parahaemolyticus) 		PF01936
(NYN) 		4 LEU A  12
LEU A 111
VAL A 109
ILE A 125
 None
 0.88A 4oj4A-2qipA:
undetectable		 4oj4A-2qipA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qj8 MLR6093 PROTEIN

(Mesorhizobium
japonicum) 		PF04952
(AstE_AspA) 		4 LEU A  21
LEU A  34
VAL A  83
ILE A  86
 None
 0.92A 4oj4A-2qj8A:
undetectable		 4oj4A-2qj8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN

(Homo sapiens) 		PF01823
(MACPF) 		4 SER A 287
LEU A 438
VAL A 437
ILE A 434
 None
 0.91A 4oj4A-2qqhA:
undetectable		 4oj4A-2qqhA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2raa PYRUVATE SYNTHASE
SUBUNIT PORC

(Thermotoga
maritima) 		PF01558
(POR) 		4 LEU A 142
LEU A 145
VAL A 146
ILE A 151
 None
 0.94A 4oj4A-2raaA:
undetectable		 4oj4A-2raaA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 LEU A  72
LEU A  81
VAL A 101
ILE A 103
 None
 0.86A 4oj4A-2v7gA:
undetectable		 4oj4A-2v7gA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		4 LEU B  24
LEU B  27
VAL A  98
ILE B   9
 None
 0.91A 4oj4A-2vmlB:
undetectable		 4oj4A-2vmlB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqd PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
aureus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 LEU A 517
VAL A 487
ILE A 483
MET A 503
 None
 0.87A 4oj4A-2wqdA:
undetectable		 4oj4A-2wqdA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		4 LEU A 594
LEU A 587
VAL A 586
ILE A 538
 None
 0.81A 4oj4A-2x6kA:
undetectable		 4oj4A-2x6kA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcx TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 LEU A 153
LEU A 157
VAL A 159
ILE A 220
 None
 0.94A 4oj4A-2zcxA:
undetectable		 4oj4A-2zcxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 263
LEU A 266
ILE A 272
MET A 292
 None
 0.93A 4oj4A-2zu6A:
undetectable		 4oj4A-2zu6A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5v ALPHA-GALACTOSIDASE

(Umbelopsis
vinacea) 		PF16499
(Melibiase_2) 		4 LEU A 270
LEU A 242
VAL A 244
ILE A 284
 None
 0.96A 4oj4A-3a5vA:
undetectable		 4oj4A-3a5vA:
19.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 285
LEU A 330
LEU A 333
VAL A 339
ILE A 341
MET A 364
 MC5  A   1 (-3.6A)
MC5  A   1 (-4.4A)
None
MC5  A   1 (-4.6A)
MC5  A   1 (-4.5A)
MC5  A   1 (-3.7A)
 0.67A 4oj4A-3b0qA:
37.4		 4oj4A-3b0qA:
98.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 SER A 289
LEU A 330
LEU A 333
VAL A 339
MET A 364
 MC5  A   1 (-2.6A)
MC5  A   1 (-4.4A)
None
MC5  A   1 (-4.6A)
MC5  A   1 (-3.7A)
 0.65A 4oj4A-3b0qA:
37.4		 4oj4A-3b0qA:
98.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvc UNCHARACTERIZED
PROTEIN ISM_01780

(Roseovarius
nubinhibens) 		PF13759
(2OG-FeII_Oxy_5) 		4 LEU A 179
LEU A 141
VAL A 171
ILE A 169
 None
 0.86A 4oj4A-3bvcA:
undetectable		 4oj4A-3bvcA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c01 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAS

(Salmonella
enterica) 		PF01312
(Bac_export_2) 		4 LEU E 307
LEU E 332
VAL E 329
ILE E 266
 None
 0.95A 4oj4A-3c01E:
undetectable		 4oj4A-3c01E:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cje OSMC-LIKE PROTEIN

(Jannaschia sp.
CCS1) 		PF02566
(OsmC) 		4 LEU A  44
LEU A  30
VAL A  32
ILE A  66
 None
 0.87A 4oj4A-3cjeA:
undetectable		 4oj4A-3cjeA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dci ARYLESTERASE

(Agrobacterium
fabrum) 		PF13472
(Lipase_GDSL_2) 		4 LEU A  74
LEU A   5
VAL A  83
ILE A  85
 None
 0.93A 4oj4A-3dciA:
undetectable		 4oj4A-3dciA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 CYH D 285
SER D 289
LEU D 330
LEU D 333
VAL D 339
ILE D 341
MET D 364
 PLB  D 701 (-3.2A)
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-4.4A)
None
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.8A)
 0.48A 4oj4A-3dzuD:
34.2		 4oj4A-3dzuD:
91.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e74 ALLANTOINASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 CYH A 241
LEU A 238
LEU A 228
VAL A 227
 KCX  A 146 ( 3.8A)
None
None
None
 0.90A 4oj4A-3e74A:
undetectable		 4oj4A-3e74A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eea GAF DOMAIN/HD DOMAIN
PROTEIN

(Geobacter
sulfurreducens) 		PF13492
(GAF_3) 		4 LEU A  25
LEU A  28
VAL A  29
MET A 126
 None
 0.94A 4oj4A-3eeaA:
undetectable		 4oj4A-3eeaA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		4 LEU A 351
LEU A 430
VAL A 428
ILE A 408
 None
 0.90A 4oj4A-3f85A:
undetectable		 4oj4A-3f85A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE

(Listeria
innocua) 		PF06838
(Met_gamma_lyase) 		4 SER A 407
LEU A 385
VAL A 387
ILE A 334
 None
 0.86A 4oj4A-3fd0A:
undetectable		 4oj4A-3fd0A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214

(Homo sapiens) 		PF12894
(ANAPC4_WD40) 		4 LEU A 100
LEU A 107
VAL A 125
ILE A  61
 None
 0.96A 4oj4A-3fhcA:
undetectable		 4oj4A-3fhcA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4e REGUCALCIN

(Homo sapiens) 		PF08450
(SGL) 		4 LEU A 227
LEU A 214
VAL A 216
ILE A 168
 None
 0.84A 4oj4A-3g4eA:
undetectable		 4oj4A-3g4eA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4e REGUCALCIN

(Homo sapiens) 		PF08450
(SGL) 		4 SER A 192
LEU A 214
VAL A 216
ILE A 168
 None
 0.84A 4oj4A-3g4eA:
undetectable		 4oj4A-3g4eA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2u RAVER-1

(Homo sapiens) 		PF00076
(RRM_1) 		4 SER B 243
LEU B 267
LEU B 223
VAL B 225
 None
 0.80A 4oj4A-3h2uB:
undetectable		 4oj4A-3h2uB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5l PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Ruegeria
pomeroyi) 		PF13458
(Peripla_BP_6) 		4 LEU A 115
LEU A 127
VAL A 130
ILE A 100
 None
 0.95A 4oj4A-3h5lA:
undetectable		 4oj4A-3h5lA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hly FLAVODOXIN-LIKE
DOMAIN

(Synechococcus
elongatus) 		no annotation 4 SER A 350
LEU A 268
LEU A 297
VAL A 328
 None
 0.81A 4oj4A-3hlyA:
undetectable		 4oj4A-3hlyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 151
LEU A 154
VAL A 155
ILE A 186
 None
 0.88A 4oj4A-3hmjA:
undetectable		 4oj4A-3hmjA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixl ARYLMALONATE
DECARBOXYLASE

(Bordetella
bronchiseptica) 		no annotation 5 SER A  76
LEU A  40
LEU A  38
VAL A  51
ILE A  52
 PAC  A5000 (-2.6A)
None
None
None
None
 1.20A 4oj4A-3ixlA:
undetectable		 4oj4A-3ixlA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixl ARYLMALONATE
DECARBOXYLASE

(Bordetella
bronchiseptica) 		no annotation 4 SER A 105
LEU A 138
LEU A 143
VAL A 120
 None
 0.91A 4oj4A-3ixlA:
undetectable		 4oj4A-3ixlA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsa HOMOSERINE
DEHYDROGENASE

(Thermoplasma
volcanium) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 LEU A  11
LEU A  19
VAL A  57
ILE A  52
 NAD  A 501 (-4.9A)
None
None
None
 0.95A 4oj4A-3jsaA:
undetectable		 4oj4A-3jsaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd9 COENZYME A DISULFIDE
REDUCTASE

(Pyrococcus
horikoshii) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 433
LEU A 374
VAL A 388
ILE A 399
MET A 405
 None
 1.41A 4oj4A-3kd9A:
undetectable		 4oj4A-3kd9A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhx KETODEOXYGLUCONOKINA
SE

(Shigella
flexneri) 		PF00294
(PfkB) 		5 SER A 210
LEU A 204
VAL A 236
ILE A 237
MET A 260
 None
 1.46A 4oj4A-3lhxA:
undetectable		 4oj4A-3lhxA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		4 LEU A  62
LEU A  65
VAL A  66
MET A  91
 None
 0.93A 4oj4A-3lkzA:
undetectable		 4oj4A-3lkzA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltw ARYLAMINE
N-ACETYLTRANSFERASE
NAT

(Mycobacterium
marinum) 		PF00797
(Acetyltransf_2) 		4 LEU A  25
LEU A  28
VAL A  29
ILE A  77
 None
 0.89A 4oj4A-3ltwA:
undetectable		 4oj4A-3ltwA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n11 CHITINASE A

(Bacillus cereus) 		PF00704
(Glyco_hydro_18) 		4 LEU A 185
LEU A 219
VAL A 215
ILE A 211
 None
 0.75A 4oj4A-3n11A:
undetectable		 4oj4A-3n11A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 CYH A 401
SER A 404
VAL A 468
ILE A 396
MET A 267
 None
 1.43A 4oj4A-3n3zA:
2.1		 4oj4A-3n3zA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		4 SER A 391
LEU A 351
LEU A 354
VAL A 402
 None
 0.96A 4oj4A-3nawA:
undetectable		 4oj4A-3nawA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o65 PUTATIVE
ATAXIN-3-LIKE
PROTEIN

(Homo sapiens) 		PF02099
(Josephin) 		4 CYH A  19
LEU A  85
LEU A  90
VAL A 166
 None
 0.95A 4oj4A-3o65A:
undetectable		 4oj4A-3o65A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on5 BH1974 PROTEIN

(Bacillus
halodurans) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		4 LEU A  58
VAL A  98
ILE A  96
MET A  37
 None
 0.95A 4oj4A-3on5A:
undetectable		 4oj4A-3on5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osj PHYCOBILISOME LCM
CORE-MEMBRANE LINKER
POLYPEPTIDE

(Synechocystis
sp. PCC 6803) 		PF00427
(PBS_linker_poly) 		4 LEU A 373
LEU A 376
VAL A 377
ILE A 350
 None
 0.90A 4oj4A-3osjA:
undetectable		 4oj4A-3osjA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1j GTPASE IMAP FAMILY
MEMBER 2

(Homo sapiens) 		PF04548
(AIG1) 		4 LEU A 168
LEU A 171
VAL A 172
MET A 160
 None
 0.82A 4oj4A-3p1jA:
undetectable		 4oj4A-3p1jA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p83 RIBONUCLEASE HII

(Archaeoglobus
fulgidus) 		PF01351
(RNase_HII) 		4 LEU D  30
LEU D  33
VAL D  35
ILE D 140
 None
 0.92A 4oj4A-3p83D:
undetectable		 4oj4A-3p83D:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN

(Pyrococcus
abyssi) 		PF00152
(tRNA-synt_2) 		4 LEU A  94
LEU A 117
VAL A 265
ILE A  21
 None
 0.94A 4oj4A-3p8tA:
undetectable		 4oj4A-3p8tA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3puo DIHYDRODIPICOLINATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00701
(DHDPS) 		4 LEU A  24
LEU A  27
VAL A  28
ILE A  39
 None
 0.94A 4oj4A-3puoA:
undetectable		 4oj4A-3puoA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		4 LEU A 207
LEU A 210
VAL A 211
ILE A 140
 None
 0.96A 4oj4A-3q9oA:
undetectable		 4oj4A-3q9oA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdq 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Clostridium
aminobutyricum) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 SER A 210
LEU A 227
LEU A 224
VAL A 223
ILE A 309
 None
 1.03A 4oj4A-3qdqA:
undetectable		 4oj4A-3qdqA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi3 HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 CYH A 401
SER A 404
VAL A 468
ILE A 396
MET A 267
 None
 1.36A 4oj4A-3qi3A:
2.1		 4oj4A-3qi3A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		4 LEU L 147
LEU L 150
VAL L 151
ILE L 449
 None
 0.74A 4oj4A-3rgwL:
undetectable		 4oj4A-3rgwL:
17.96